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<meta name="keywords" content="C0424688, decreased head circumference, finding, reduced head circumference, small calvarium, small head, small head circumference, small head size, small skull, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=473122
|
||
ConceptID=C0424688
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased head circumference</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>473122</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0424688</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Reduced head circumference; Small calvarium; Small head; Small head circumference; Small head size</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Small head (271611007); Small skull (271611007)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0040195">HP:0040195</a></td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Decreased head circumference</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1763488" ref="tree=MeSH" title="MedGen record for Abnormality of the musculoskeletal system">Abnormality of the musculoskeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/867418" ref="tree=MeSH" title="MedGen record for Abnormality of the skeletal system">Abnormality of the skeletal system</a></span><ul><li><span class="TLline"><a href="/medgen/868760" ref="tree=MeSH" title="MedGen record for Abnormal skeletal morphology">Abnormal skeletal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892434" ref="tree=MeSH" title="MedGen record for Abnormal axial skeleton morphology">Abnormal axial skeleton morphology</a></span><ul><li><span class="TLline"><a href="/medgen/488801" ref="tree=MeSH" title="MedGen record for Abnormal skull morphology">Abnormal skull morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871378" ref="tree=MeSH" title="MedGen record for Abnormality of skull size">Abnormality of skull size</a></span><ul><li><span class="matched_ds">Decreased head circumference</span><ul><li><span class="TLline"><a href="/medgen/1644158" ref="tree=MeSH" title="MedGen record for Microcephaly">Microcephaly</a></span><ul><li><span class="TLline"><a href="/medgen/383046" ref="tree=MeSH" title="MedGen record for Primary microcephaly">Primary microcephaly</a></span></li><li><span class="TLline"><a href="/medgen/608952" ref="tree=MeSH" title="MedGen record for Secondary microcephaly">Secondary microcephaly</a></span><ul><li><span class="TLline"><a href="/medgen/870859" ref="tree=MeSH" title="MedGen record for Cessation of head growth">Cessation of head growth</a></span></li><li><span class="TLline"><a href="/medgen/340542" ref="tree=MeSH" title="MedGen record for Progressive microcephaly">Progressive microcephaly</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/332294" ref="tree=MeSH" title="MedGen record for Mild microcephaly">Mild microcephaly</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_1622363"><div><strong>Developmental and epileptic encephalopathy, 55</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1622363</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4539843</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Developmental and epileptic encephalopathy-55 (DEE55) is an autosomal recessive neurologic disorder characterized by onset of refractory seizures in the first weeks or months of life. Affected individuals have an extremely poor outcome, with profoundly impaired intellectual development, absent speech, spastic quadriplegia, and dyskinetic movements. Most have cortical visual impairment and require a feeding tube. Brain imaging shows nonspecific abnormalities, including cerebral atrophy, thin corpus callosum, and abnormal signals in the white matter. Death in childhood may occur. Biochemically, the disorder is associated with impaired synthesis of GPI-anchored proteins (summary by Vetro et al., 2020). For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1622363">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1611968"><div><strong>Al Kaissi syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1611968</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540156</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Al Kaissi syndrome (ALKAS) is an autosomal recessive developmental disorder characterized by growth retardation, spine malformation, particularly of the cervical spine, dysmorphic facial features, and delayed psychomotor development with moderate to severe intellectual disability (summary by Windpassinger et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1611968">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1776566"><div><strong>Vissers-Bodmer syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1776566</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436647</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Vissers-Bodmer syndrome (VIBOS) is characterized by global developmental delay with variably impaired intellectual development, speech delay, motor delay, and behavioral abnormalities apparent from infancy. The phenotype is highly variable: some individuals have only mild learning difficulties, whereas others have severe cognitive impairment with IQ in the 50s. Many patients have behavioral abnormalities, including autism spectrum disorder, ADD, ADHD, obsessive-compulsive disorder, and impulsivity. Other common features include growth impairment abnormalities, hypotonia, and distal skeletal defects, such as foot and hand deformities. Less common features include seizures, brain abnormalities on MRI, feeding problems, and joint hypermobility. Most individuals have dysmorphic facial features, but there is no recognizable gestalt (summary by Vissers et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1776566">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1611968" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Al Kaissi syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1622363" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy, 55</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1776566" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vissers-Bodmer syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37241131">Fetal Biometric Assessment and Infant Developmental Prognosis of the Tadalafil Treatment for Fetal Growth Restriction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsuji M,
|
||
Maki S,
|
||
Enomoto N,
|
||
Okamoto K,
|
||
Kitamura A,
|
||
Magawa S,
|
||
Takakura S,
|
||
Nii M,
|
||
Tanaka K,
|
||
Yodoya N,
|
||
Tanaka H,
|
||
Sawada H,
|
||
Kondo E,
|
||
Hirayama M,
|
||
Ikeda T</span><br />
|
||
<span class="medgenPMjournal">Medicina (Kaunas)</span>
|
||
2023 May 8;59(5)
|
||
doi: 10.3390/medicina59050900.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37241131" target="_blank">37241131</a><a href="/pmc/articles/PMC10223650" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34607328">Follow-Up Study of Growth Hormone Therapy in Children with Kabuki Syndrome: Two-Year Treatment Results.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Montfort L,
|
||
Gerver WJM,
|
||
Kooger BLS,
|
||
Plat J,
|
||
Bierau J,
|
||
Stumpel CTRM,
|
||
Schott DA</span><br />
|
||
<span class="medgenPMjournal">Horm Res Paediatr</span>
|
||
2021;94(7-8):285-296.
|
||
Epub 2021 Oct 4
|
||
doi: 10.1159/000519963.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34607328" target="_blank">34607328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3547986">Fetal hydrocephaly: diagnosis, prognosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Egmond-Linden A,
|
||
Wladimiroff JW,
|
||
Niermeijer MF,
|
||
Stewart PA</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Med Biol</span>
|
||
1986 Dec;12(12):939-44.
|
||
doi: 10.1016/0301-5629(86)90062-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3547986" target="_blank">3547986</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20head%20circumference)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (27)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36632790">Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khare SP,
|
||
Madhok A,
|
||
Patta I,
|
||
Sukla KK,
|
||
Wagh VV,
|
||
Kunte PS,
|
||
Raut D,
|
||
Bhat D,
|
||
Kumaran K,
|
||
Fall C,
|
||
Tatu U,
|
||
Chandak GR,
|
||
Yajnik CS,
|
||
Galande S</span><br />
|
||
<span class="medgenPMjournal">J Dev Orig Health Dis</span>
|
||
2023 Jun;14(3):437-448.
|
||
Epub 2023 Jan 12
|
||
doi: 10.1017/S204017442200068X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36632790" target="_blank">36632790</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35609643">Placental vascular malperfusion lesions in fetal congenital heart disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leon RL,
|
||
Sharma K,
|
||
Mir IN,
|
||
Herrera CL,
|
||
Brown SL,
|
||
Spong CY,
|
||
Chalak LF</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2022 Oct;227(4):620.e1-620.e8.
|
||
Epub 2022 May 21
|
||
doi: 10.1016/j.ajog.2022.05.038.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35609643" target="_blank">35609643</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35500464">Head circumference in glucose transporter 1 deficiency syndrome: Normal for individuals, abnormal as a group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Gemert LA,
|
||
Leen WG,
|
||
Draaisma JM,
|
||
Roeleveld N,
|
||
Willemsen MA</span><br />
|
||
<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
|
||
2022 May;38:73-76.
|
||
Epub 2022 Apr 27
|
||
doi: 10.1016/j.ejpn.2022.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35500464" target="_blank">35500464</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34885894">Effects of Prenatal Exposure to Aflatoxin B1: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">da Silva JVB,
|
||
de Oliveira CAF,
|
||
Ramalho LNZ</span><br />
|
||
<span class="medgenPMjournal">Molecules</span>
|
||
2021 Dec 2;26(23)
|
||
doi: 10.3390/molecules26237312.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34885894" target="_blank">34885894</a><a href="/pmc/articles/PMC8659025" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2190424">Drug-exposed neonates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hoegerman G,
|
||
Wilson CA,
|
||
Thurmond E,
|
||
Schnoll SH</span><br />
|
||
<span class="medgenPMjournal">West J Med</span>
|
||
1990 May;152(5):559-64.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2190424" target="_blank">2190424</a><a href="/pmc/articles/PMC1002411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20head%20circumference%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35609643">Placental vascular malperfusion lesions in fetal congenital heart disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leon RL,
|
||
Sharma K,
|
||
Mir IN,
|
||
Herrera CL,
|
||
Brown SL,
|
||
Spong CY,
|
||
Chalak LF</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2022 Oct;227(4):620.e1-620.e8.
|
||
Epub 2022 May 21
|
||
doi: 10.1016/j.ajog.2022.05.038.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35609643" target="_blank">35609643</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28635121">Exposure to Sodium Valproate during Pregnancy: Facial Features and Signs of Autism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stadelmaier R,
|
||
Nasri H,
|
||
Deutsch CK,
|
||
Bauman M,
|
||
Hunt A,
|
||
Stodgell CJ,
|
||
Adams J,
|
||
Holmes LB</span><br />
|
||
<span class="medgenPMjournal">Birth Defects Res</span>
|
||
2017 Aug 15;109(14):1134-1143.
|
||
Epub 2017 Jun 21
|
||
doi: 10.1002/bdr2.1052.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28635121" target="_blank">28635121</a><a href="/pmc/articles/PMC5555794" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28500962">The methylation levels of the H19 differentially methylated region in human umbilical cords reflect newborn parameters and changes by maternal environmental factors during early pregnancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miyaso H,
|
||
Sakurai K,
|
||
Takase S,
|
||
Eguchi A,
|
||
Watanabe M,
|
||
Fukuoka H,
|
||
Mori C</span><br />
|
||
<span class="medgenPMjournal">Environ Res</span>
|
||
2017 Aug;157:1-8.
|
||
Epub 2017 May 10
|
||
doi: 10.1016/j.envres.2017.05.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28500962" target="_blank">28500962</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23044015">Decreased head circumference velocity as related to developmental deficit in infancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tal G,
|
||
Cohen A,
|
||
Habib S,
|
||
Tirosh E</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
2012 Nov;47(5):341-4.
|
||
doi: 10.1016/j.pediatrneurol.2012.07.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23044015" target="_blank">23044015</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2190424">Drug-exposed neonates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hoegerman G,
|
||
Wilson CA,
|
||
Thurmond E,
|
||
Schnoll SH</span><br />
|
||
<span class="medgenPMjournal">West J Med</span>
|
||
1990 May;152(5):559-64.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2190424" target="_blank">2190424</a><a href="/pmc/articles/PMC1002411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20head%20circumference%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36632790">Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khare SP,
|
||
Madhok A,
|
||
Patta I,
|
||
Sukla KK,
|
||
Wagh VV,
|
||
Kunte PS,
|
||
Raut D,
|
||
Bhat D,
|
||
Kumaran K,
|
||
Fall C,
|
||
Tatu U,
|
||
Chandak GR,
|
||
Yajnik CS,
|
||
Galande S</span><br />
|
||
<span class="medgenPMjournal">J Dev Orig Health Dis</span>
|
||
2023 Jun;14(3):437-448.
|
||
Epub 2023 Jan 12
|
||
doi: 10.1017/S204017442200068X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36632790" target="_blank">36632790</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34831248">Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ghazi T,
|
||
Naidoo P,
|
||
Naidoo RN,
|
||
Chuturgoon AA</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Nov 5;10(11)
|
||
doi: 10.3390/cells10113025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34831248" target="_blank">34831248</a><a href="/pmc/articles/PMC8616150" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34556740">Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shiohama T,
|
||
Hisada A,
|
||
Yamamoto M,
|
||
Sakurai K,
|
||
Takatani R,
|
||
Fujii K,
|
||
Shimojo N,
|
||
Mori C;
|
||
Japan Environment Children’s Study (JECS) Group</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Sep 23;11(1):18949.
|
||
doi: 10.1038/s41598-021-98311-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34556740" target="_blank">34556740</a><a href="/pmc/articles/PMC8460647" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25106748">Physical, behavioral, and cognitive effects of prenatal tobacco and postnatal secondhand smoke exposure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou S,
|
||
Rosenthal DG,
|
||
Sherman S,
|
||
Zelikoff J,
|
||
Gordon T,
|
||
Weitzman M</span><br />
|
||
<span class="medgenPMjournal">Curr Probl Pediatr Adolesc Health Care</span>
|
||
2014 Sep;44(8):219-41.
|
||
Epub 2014 Jun 25
|
||
doi: 10.1016/j.cppeds.2014.03.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25106748" target="_blank">25106748</a><a href="/pmc/articles/PMC6876620" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24032988">Decreased head circumference in shunt-treated compared with healthy children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nilsson D,
|
||
Svensson J,
|
||
Korkmaz BA,
|
||
Nelvig H,
|
||
Tisell M</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg Pediatr</span>
|
||
2013 Nov;12(5):483-90.
|
||
Epub 2013 Sep 13
|
||
doi: 10.3171/2013.8.PEDS1370.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24032988" target="_blank">24032988</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20head%20circumference%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36632790">Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khare SP,
|
||
Madhok A,
|
||
Patta I,
|
||
Sukla KK,
|
||
Wagh VV,
|
||
Kunte PS,
|
||
Raut D,
|
||
Bhat D,
|
||
Kumaran K,
|
||
Fall C,
|
||
Tatu U,
|
||
Chandak GR,
|
||
Yajnik CS,
|
||
Galande S</span><br />
|
||
<span class="medgenPMjournal">J Dev Orig Health Dis</span>
|
||
2023 Jun;14(3):437-448.
|
||
Epub 2023 Jan 12
|
||
doi: 10.1017/S204017442200068X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36632790" target="_blank">36632790</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24032988">Decreased head circumference in shunt-treated compared with healthy children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nilsson D,
|
||
Svensson J,
|
||
Korkmaz BA,
|
||
Nelvig H,
|
||
Tisell M</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg Pediatr</span>
|
||
2013 Nov;12(5):483-90.
|
||
Epub 2013 Sep 13
|
||
doi: 10.3171/2013.8.PEDS1370.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24032988" target="_blank">24032988</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19695324">Continued effects of prenatal cocaine use: preschool development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Richardson GA,
|
||
Goldschmidt L,
|
||
Willford J</span><br />
|
||
<span class="medgenPMjournal">Neurotoxicol Teratol</span>
|
||
2009 Nov-Dec;31(6):325-33.
|
||
Epub 2009 Aug 18
|
||
doi: 10.1016/j.ntt.2009.08.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19695324" target="_blank">19695324</a><a href="/pmc/articles/PMC2765398" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18845770">Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gray TR,
|
||
Magri R,
|
||
Shakleya DM,
|
||
Huestis MA</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2008 Dec;54(12):2018-27.
|
||
Epub 2008 Oct 9
|
||
doi: 10.1373/clinchem.2008.109173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18845770" target="_blank">18845770</a><a href="/pmc/articles/PMC3163082" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1351263">Neurodevelopment in late infancy after prenatal exposure to benzodiazepines--a prospective study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Laegreid L,
|
||
Hagberg G,
|
||
Lundberg A</span><br />
|
||
<span class="medgenPMjournal">Neuropediatrics</span>
|
||
1992 Apr;23(2):60-7.
|
||
doi: 10.1055/s-2008-1071314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1351263" target="_blank">1351263</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20head%20circumference%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36632790">Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khare SP,
|
||
Madhok A,
|
||
Patta I,
|
||
Sukla KK,
|
||
Wagh VV,
|
||
Kunte PS,
|
||
Raut D,
|
||
Bhat D,
|
||
Kumaran K,
|
||
Fall C,
|
||
Tatu U,
|
||
Chandak GR,
|
||
Yajnik CS,
|
||
Galande S</span><br />
|
||
<span class="medgenPMjournal">J Dev Orig Health Dis</span>
|
||
2023 Jun;14(3):437-448.
|
||
Epub 2023 Jan 12
|
||
doi: 10.1017/S204017442200068X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36632790" target="_blank">36632790</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35609643">Placental vascular malperfusion lesions in fetal congenital heart disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leon RL,
|
||
Sharma K,
|
||
Mir IN,
|
||
Herrera CL,
|
||
Brown SL,
|
||
Spong CY,
|
||
Chalak LF</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2022 Oct;227(4):620.e1-620.e8.
|
||
Epub 2022 May 21
|
||
doi: 10.1016/j.ajog.2022.05.038.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35609643" target="_blank">35609643</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35500464">Head circumference in glucose transporter 1 deficiency syndrome: Normal for individuals, abnormal as a group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van Gemert LA,
|
||
Leen WG,
|
||
Draaisma JM,
|
||
Roeleveld N,
|
||
Willemsen MA</span><br />
|
||
<span class="medgenPMjournal">Eur J Paediatr Neurol</span>
|
||
2022 May;38:73-76.
|
||
Epub 2022 Apr 27
|
||
doi: 10.1016/j.ejpn.2022.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35500464" target="_blank">35500464</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23044015">Decreased head circumference velocity as related to developmental deficit in infancy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tal G,
|
||
Cohen A,
|
||
Habib S,
|
||
Tirosh E</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
2012 Nov;47(5):341-4.
|
||
doi: 10.1016/j.pediatrneurol.2012.07.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23044015" target="_blank">23044015</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7065696">Klinefelter's syndrome in adolescence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ratcliffe SG,
|
||
Bancroft J,
|
||
Axworthy D,
|
||
McLaren W</span><br />
|
||
<span class="medgenPMjournal">Arch Dis Child</span>
|
||
1982 Jan;57(1):6-12.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7065696" target="_blank">7065696</a><a href="/pmc/articles/PMC2863282" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20head%20circumference%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20head%20circumference)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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