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<meta name="keywords" content="C0278701, adenocarcinoma - stomach, adenocarcinoma of stomach, adenocarcinoma of the stomach, cancer of stomach, adenocarcinoma, gastric (stomach) adenocarcinoma, gastric adenocarcinoma, neoplastic process, non rare in europe: adenocarcinoma of stomach, stad, stomach adenocarcinoma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=82961
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ConceptID=C0278701
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Gastric adenocarcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82961</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0278701</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Adenocarcinoma of stomach</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Adenocarcinoma of stomach (408647009); Cancer of stomach, adenocarcinoma (408647009)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0033770">HP:0033770</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005036" target="_blank">MONDO:0005036</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=464463">ORPHA464463</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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||
<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Gastric adenocarcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="matched_ds">Gastric adenocarcinoma</span><ul><li><span class="TLline"><a href="/medgen/79019" ref="tree=MeSH" title="MedGen record for Diffuse gastric adenocarcinoma">Diffuse gastric adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1655189" ref="tree=MeSH" title="MedGen record for Hereditary Gastric Diffuse Adenocarcinoma">Hereditary Gastric Diffuse Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/328047" ref="tree=MeSH" title="MedGen record for Sporadic Gastric Diffuse Adenocarcinoma">Sporadic Gastric Diffuse Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1658765" ref="tree=MeSH" title="MedGen record for Metastatic Gastric Adenocarcinoma">Metastatic Gastric Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1708925" ref="tree=MeSH" title="MedGen record for Advanced Gastric Adenocarcinoma">Advanced Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1689661" ref="tree=MeSH" title="MedGen record for Locally Advanced Gastric Adenocarcinoma">Locally Advanced Gastric Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1657181" ref="tree=MeSH" title="MedGen record for Locally Advanced Unresectable Gastric Adenocarcinoma">Locally Advanced Unresectable Gastric Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1711891" ref="tree=MeSH" title="MedGen record for Metastatic Proximal Gastric Adenocarcinoma">Metastatic Proximal Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1653879" ref="tree=MeSH" title="MedGen record for Metastatic Unresectable Gastric Adenocarcinoma">Metastatic Unresectable Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712044" ref="tree=MeSH" title="MedGen record for Oligometastatic Gastric Adenocarcinoma">Oligometastatic Gastric Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1718863" ref="tree=MeSH" title="MedGen record for Proximal Gastric Adenocarcinoma">Proximal Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649479" ref="tree=MeSH" title="MedGen record for Recurrent Gastric Adenocarcinoma">Recurrent Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712797" ref="tree=MeSH" title="MedGen record for Refractory Gastric Adenocarcinoma">Refractory Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/328294" ref="tree=MeSH" title="MedGen record for Sporadic Gastric Adenocarcinoma">Sporadic Gastric Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/459623" ref="tree=MeSH" title="MedGen record for Gastric Carcinoma with Lymphoid Stroma">Gastric Carcinoma with Lymphoid Stroma</a></span></li><li><span class="TLline"><a href="/medgen/232543" ref="tree=MeSH" title="MedGen record for Gastric cardia adenocarcinoma">Gastric cardia adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459622" ref="tree=MeSH" title="MedGen record for Gastric Hepatoid Adenocarcinoma">Gastric Hepatoid Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/79017" ref="tree=MeSH" title="MedGen record for Gastric intestinal type adenocarcinoma">Gastric intestinal type adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/389797" ref="tree=MeSH" title="MedGen record for Gastric Mixed Adenocarcinoma">Gastric Mixed Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/232550" ref="tree=MeSH" title="MedGen record for Gastric papillary adenocarcinoma">Gastric papillary adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/226833" ref="tree=MeSH" title="MedGen record for Gastric Parietal Cell Adenocarcinoma">Gastric Parietal Cell Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/459619" ref="tree=MeSH" title="MedGen record for Gastric Poorly Cohesive Adenocarcinoma">Gastric Poorly Cohesive Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/234782" ref="tree=MeSH" title="MedGen record for Signet ring cell gastric adenocarcinoma">Signet ring cell gastric adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234303" ref="tree=MeSH" title="MedGen record for Gastric tubular adenocarcinoma">Gastric tubular adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234338" ref="tree=MeSH" title="MedGen record for Helicobacter Pylori-Related Gastric Adenocarcinoma">Helicobacter Pylori-Related Gastric Adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/138098" ref="tree=MeSH" title="MedGen record for Microinvasive gastric cancer">Microinvasive gastric cancer</a></span><ul><li><span class="TLline"><a href="/medgen/459632" ref="tree=MeSH" title="MedGen record for Gastric Intramucosal Adenocarcinoma">Gastric Intramucosal Adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/235338" ref="tree=MeSH" title="MedGen record for Mucinous gastric adenocarcinoma">Mucinous gastric adenocarcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1662439" ref="tree=MeSH" title="MedGen record for Unresectable Gastric Adenocarcinoma">Unresectable Gastric Adenocarcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_934686"><div><strong>Familial adenomatous polyposis 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934686</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310719</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934686">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1657285"><div><strong>Gastric adenocarcinoma and proximal polyposis of the stomach</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1657285</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4749917</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1657285">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934686" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adenomatous polyposis 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1657285" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastric adenocarcinoma and proximal polyposis of the stomach</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33592120">Current treatment and recent progress in gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Joshi SS,
|
||
Badgwell BD</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2021 May;71(3):264-279.
|
||
Epub 2021 Feb 16
|
||
doi: 10.3322/caac.21657.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33592120" target="_blank">33592120</a><a href="/pmc/articles/PMC9927927" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32894370">Gastric cancer: a comprehensive review of current and future treatment strategies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sexton RE,
|
||
Al Hallak MN,
|
||
Diab M,
|
||
Azmi AS</span><br />
|
||
<span class="medgenPMjournal">Cancer Metastasis Rev</span>
|
||
2020 Dec;39(4):1179-1203.
|
||
Epub 2020 Sep 7
|
||
doi: 10.1007/s10555-020-09925-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32894370" target="_blank">32894370</a><a href="/pmc/articles/PMC7680370" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30841008">Management of epithelial precancerous conditions and lesions in the stomach (MAPS II): European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter and Microbiota Study Group (EHMSG), European Society of Pathology (ESP), and Sociedade Portuguesa de Endoscopia Digestiva (SPED) guideline update 2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pimentel-Nunes P,
|
||
Libânio D,
|
||
Marcos-Pinto R,
|
||
Areia M,
|
||
Leja M,
|
||
Esposito G,
|
||
Garrido M,
|
||
Kikuste I,
|
||
Megraud F,
|
||
Matysiak-Budnik T,
|
||
Annibale B,
|
||
Dumonceau JM,
|
||
Barros R,
|
||
Fléjou JF,
|
||
Carneiro F,
|
||
van Hooft JE,
|
||
Kuipers EJ,
|
||
Dinis-Ribeiro M</span><br />
|
||
<span class="medgenPMjournal">Endoscopy</span>
|
||
2019 Apr;51(4):365-388.
|
||
Epub 2019 Mar 6
|
||
doi: 10.1055/a-0859-1883.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30841008" target="_blank">30841008</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22gastric%20adenocarcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (279)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39631917">Fundic gland adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goel A,
|
||
Agrawal K,
|
||
Mukherjee U,
|
||
Singla V</span><br />
|
||
<span class="medgenPMjournal">BMJ Case Rep</span>
|
||
2024 Dec 3;17(12)
|
||
doi: 10.1136/bcr-2024-261983.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39631917" target="_blank">39631917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34053633">Helicobacter pylori and Gastric Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim J,
|
||
Wang TC</span><br />
|
||
<span class="medgenPMjournal">Gastrointest Endosc Clin N Am</span>
|
||
2021 Jul;31(3):451-465.
|
||
doi: 10.1016/j.giec.2021.03.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34053633" target="_blank">34053633</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30900101">The therapeutic potential of metformin in gastric cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Courtois S,
|
||
Lehours P,
|
||
Bessède E</span><br />
|
||
<span class="medgenPMjournal">Gastric Cancer</span>
|
||
2019 Jul;22(4):653-662.
|
||
Epub 2019 Mar 21
|
||
doi: 10.1007/s10120-019-00952-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30900101" target="_blank">30900101</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30355265">Gastric Cancer Etiology and Management in Asia and the West.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Russo AE,
|
||
Strong VE</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
2019 Jan 27;70:353-367.
|
||
Epub 2018 Oct 24
|
||
doi: 10.1146/annurev-med-081117-043436.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30355265" target="_blank">30355265</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23639642">Gastric cancer chemoprevention: the current evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tan VP,
|
||
Wong BC</span><br />
|
||
<span class="medgenPMjournal">Gastroenterol Clin North Am</span>
|
||
2013 Jun;42(2):299-316.
|
||
Epub 2013 Mar 13
|
||
doi: 10.1016/j.gtc.2013.02.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23639642" target="_blank">23639642</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3009)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37146950">Advanced gastric adenocarcinoma misdiagnosed as gastric stromal tumor.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hu D,
|
||
Zhou X,
|
||
Si X</span><br />
|
||
<span class="medgenPMjournal">Gastrointest Endosc</span>
|
||
2023 Aug;98(2):257-258.
|
||
Epub 2023 May 4
|
||
doi: 10.1016/j.gie.2023.04.2084.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37146950" target="_blank">37146950</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35469992">Diagnosis of gastric adenocarcinoma by a subcutaneous metastasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferreres Serafini J,
|
||
Olona Casas C,
|
||
Adalid Llansa L,
|
||
Jorba Martín R</span><br />
|
||
<span class="medgenPMjournal">Cir Esp (Engl Ed)</span>
|
||
2022 May;100(5):302.
|
||
Epub 2022 Apr 22
|
||
doi: 10.1016/j.cireng.2022.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35469992" target="_blank">35469992</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34807275">The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kushima R</span><br />
|
||
<span class="medgenPMjournal">Pathologe</span>
|
||
2022 Feb;43(1):8-15.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1007/s00292-021-01023-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34807275" target="_blank">34807275</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31236716">Updates on Management of Gastric Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johnston FM,
|
||
Beckman M</span><br />
|
||
<span class="medgenPMjournal">Curr Oncol Rep</span>
|
||
2019 Jun 24;21(8):67.
|
||
doi: 10.1007/s11912-019-0820-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31236716" target="_blank">31236716</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7231255">Lymphangitis carcinomatosa.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tesar PJ,
|
||
Goy J,
|
||
Maynard J</span><br />
|
||
<span class="medgenPMjournal">Med J Aust</span>
|
||
1981 Jan 24;1(2):80-1.
|
||
doi: 10.5694/j.1326-5377.1981.tb135328.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7231255" target="_blank">7231255</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2234)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39315517">Targeted and combination immunotherapies using biologics for gastric cancer: the state-of-the-art.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogers JE,
|
||
Gan Q,
|
||
Waters RE,
|
||
Horak AA,
|
||
Ajani JA</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Biol Ther</span>
|
||
2024 Oct;24(10):1005-1015.
|
||
Epub 2024 Oct 4
|
||
doi: 10.1080/14712598.2024.2401622.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39315517" target="_blank">39315517</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37948843">Treatment of gastric adenocarcinoma: A rapidly evolving landscape.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taieb J,
|
||
Bennouna J,
|
||
Penault-Llorca F,
|
||
Basile D,
|
||
Samalin E,
|
||
Zaanan A</span><br />
|
||
<span class="medgenPMjournal">Eur J Cancer</span>
|
||
2023 Dec;195:113370.
|
||
Epub 2023 Oct 17
|
||
doi: 10.1016/j.ejca.2023.113370.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37948843" target="_blank">37948843</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36603169">Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shah MA,
|
||
Kennedy EB,
|
||
Alarcon-Rozas AE,
|
||
Alcindor T,
|
||
Bartley AN,
|
||
Malowany AB,
|
||
Bhadkamkar NA,
|
||
Deighton DC,
|
||
Janjigian Y,
|
||
Karippot A,
|
||
Khan U,
|
||
King DA,
|
||
Klute K,
|
||
Lacy J,
|
||
Lee JJ,
|
||
Mehta R,
|
||
Mukherjee S,
|
||
Nagarajan A,
|
||
Park H,
|
||
Saeed A,
|
||
Semrad TJ,
|
||
Shitara K,
|
||
Smyth E,
|
||
Uboha NV,
|
||
Vincelli M,
|
||
Wainberg Z,
|
||
Rajdev L</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2023 Mar 1;41(7):1470-1491.
|
||
Epub 2023 Jan 5
|
||
doi: 10.1200/JCO.22.02331.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36603169" target="_blank">36603169</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32894370">Gastric cancer: a comprehensive review of current and future treatment strategies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sexton RE,
|
||
Al Hallak MN,
|
||
Diab M,
|
||
Azmi AS</span><br />
|
||
<span class="medgenPMjournal">Cancer Metastasis Rev</span>
|
||
2020 Dec;39(4):1179-1203.
|
||
Epub 2020 Sep 7
|
||
doi: 10.1007/s10555-020-09925-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32894370" target="_blank">32894370</a><a href="/pmc/articles/PMC7680370" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31236716">Updates on Management of Gastric Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johnston FM,
|
||
Beckman M</span><br />
|
||
<span class="medgenPMjournal">Curr Oncol Rep</span>
|
||
2019 Jun 24;21(8):67.
|
||
doi: 10.1007/s11912-019-0820-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31236716" target="_blank">31236716</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1518)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33262519">Development and validation of a novel staging system integrating the number and location of lymph nodes for gastric adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Z,
|
||
Wu X,
|
||
Gao X,
|
||
Shan F,
|
||
Ying X,
|
||
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<div class="nl"><a target="_blank" href="/pubmed/36724786">Multiplex immune profiling reveals the role of serum immune proteomics in predicting response to preoperative chemotherapy of gastric cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tang Z,
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Shi Z,
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Min L,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2115)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/38941672">Perioperative immune checkpoint inhibitors combined with chemotherapy versus chemotherapy for locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: A systematic review and meta-analysis of randomized controlled trials.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/38941672" target="_blank">38941672</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38722804">Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.</a></div>
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Mannucci A,
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<span class="medgenPMjournal">Br J Surg</span>
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2024 May 3;111(5)
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<span class="bold">PMID: </span><a href="/pubmed/38722804" target="_blank">38722804</a><a href="/pmc/articles/PMC11081080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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||
<div class="nl"><a target="_blank" href="/pubmed/38383390">Efficacy and safety of Zolbetuximab plus chemotherapy for advanced CLDN18.2-positive gastric or gastro-oesophageal adenocarcinoma: a meta-analysis of randomized clinical trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">de Moraes FCA,
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Pasqualotto E,
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Chavez MP,
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Ferreira ROM,
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||
doi: 10.1186/s12885-024-11980-w.
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<span class="bold">PMID: </span><a href="/pubmed/38383390" target="_blank">38383390</a><a href="/pmc/articles/PMC10882870" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36603169">Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Shah MA,
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Kennedy EB,
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Alarcon-Rozas AE,
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Alcindor T,
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Bartley AN,
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Malowany AB,
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Bhadkamkar NA,
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Deighton DC,
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Janjigian Y,
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Karippot A,
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Khan U,
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King DA,
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Klute K,
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Lacy J,
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Lee JJ,
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Mehta R,
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Mukherjee S,
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Nagarajan A,
|
||
Park H,
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Saeed A,
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Semrad TJ,
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Shitara K,
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Smyth E,
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Uboha NV,
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Wainberg Z,
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<span class="medgenPMjournal">J Clin Oncol</span>
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2023 Mar 1;41(7):1470-1491.
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Epub 2023 Jan 5
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||
<span class="bold">PMID: </span><a href="/pubmed/36603169" target="_blank">36603169</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33278677">A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Formica V,
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Morelli C,
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Patrikidou A,
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Shiu KK,
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Nardecchia A,
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<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
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<span class="bold">PMID: </span><a href="/pubmed/33278677" target="_blank">33278677</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gastric%20adenocarcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div></div>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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