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<meta name="keywords" content="C0242383, aamd - age related macular degeneration, age related macular degeneration, age related maculopathies, age related maculopathy, age-related macular degeneration, age-related macular degenerations, age-related maculopathies, age-related maculopathy, amd, amd - age-related macular degeneration, armd, armd - age-related macular degeneration, disease or syndrome, macular degeneration, age related, macular degeneration, age-related, macular degeneration, age-related, reduced risk of, maculopathies, age-related, maculopathy, age related, maculopathy, age-related, non rare in europe: age-related macular degeneration, senile macular degeneration, senile macular retinal degeneration, smd - senile macular degeneration, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. Subtle abnormalities indicating changes in vision may occur in a person's forties or fifties. Distorted vision and vision loss usually become noticeable in a person's sixties or seventies and tend to worsen over time.\n\nAge-related macular degeneration mainly affects central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. The vision loss in this condition results from a gradual deterioration of light-sensing cells in the tissue at the back of the eye that detects light and color (the retina). Specifically, age-related macular degeneration affects a small area near the center of the retina, called the macula, which is responsible for central vision. Side (peripheral) vision and night vision are generally not affected, but slow adjustment of vision to darkness (dark adaptation) and reduced dim light (scotopic) vision often occur in the early stages of the disease.\n\nResearchers have described two major types of age-related macular degeneration, known as the dry form and the wet form. The dry form is much more common, accounting for 85 to 90 percent of all cases of age-related macular degeneration. It is characterized by a buildup of yellowish deposits called drusen beneath the retina and vision loss that worsens slowly over time. The most advanced stage of dry age-related macular degeneration is known as geographic atrophy, in which areas of the macula waste away (atrophy), resulting in severe vision loss. Dry age-related macular degeneration typically affects vision in both eyes, although vision loss often occurs in one eye before the other.\n\nIn 10 to 15 percent of affected individuals, the dry form progresses to the wet form of age-related macular degeneration. The wet form is characterized by the growth of abnormal, fragile blood vessels underneath the macula. These vessels leak blood and fluid, which damages the macula and makes central vision appear blurry and distorted. The wet form of age-related macular degeneration is associated with severe vision loss that can worsen rapidly." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=116576
|
||
ConceptID=C0242383
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Age-related macular degeneration<span class="h1sub">(ARMD)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>116576</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0242383</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>ARMD; MACULAR DEGENERATION, AGE-RELATED, REDUCED RISK OF</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>AAMD - Age related macular degeneration (267718000); Age related macular degeneration (267718000); Age-related macular degeneration (267718000); ARMD - Age-related macular degeneration (267718000); Senile macular retinal degeneration (267718000); SMD - Senile macular degeneration (267718000); AMD - Age-related macular degeneration (267718000); Senile macular degeneration (267718000)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/387715">ARMS2</a>, <a target="_blank" href="/gene/84839">RAX2</a>, <a target="_blank" href="/gene/83872">HMCN1</a>, <a target="_blank" href="/gene/10878">CFHR3</a>, <a target="_blank" href="/gene/10516">FBLN5</a>, <a target="_blank" href="/gene/5654">HTRA1</a>, <a target="_blank" href="/gene/3426">CFI</a>, <a target="_blank" href="/gene/3078">CFHR1</a>, <a target="_blank" href="/gene/3075">CFH</a>, <a target="_blank" href="/gene/2074">ERCC6</a>, <a target="_blank" href="/gene/1524">CX3CR1</a>, <a target="_blank" href="/gene/1471">CST3</a>, <a target="_blank" href="/gene/735">C9</a>, <a target="_blank" href="/gene/718">C3</a>, <a target="_blank" href="/gene/717">C2</a>, <a target="_blank" href="/gene/629">CFB</a>, <a target="_blank" href="/gene/348">APOE</a>, <a target="_blank" href="/gene/24">ABCA4</a></td></tr><tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005150" target="_blank">MONDO:0005150</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/590050" target="_blank">590050</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span> Phenotypic series:</td>
|
||
<td><a href="https://omim.org/phenotypicSeries/PS603075" target="_blank">PS603075</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=279">ORPHA279</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Age-related macular degeneration is an eye disease that is a leading cause of vision loss in older people in developed countries. Subtle abnormalities indicating changes in vision may occur in a person's forties or fifties. Distorted vision and vision loss usually become noticeable in a person's sixties or seventies and tend to worsen over time.<br /><br />Age-related macular degeneration mainly affects central vision, which is needed for detailed tasks such as reading, driving, and recognizing faces. The vision loss in this condition results from a gradual deterioration of light-sensing cells in the tissue at the back of the eye that detects light and color (the retina). Specifically, age-related macular degeneration affects a small area near the center of the retina, called the macula, which is responsible for central vision. Side (peripheral) vision and night vision are generally not affected, but slow adjustment of vision to darkness (dark adaptation) and reduced dim light (scotopic) vision often occur in the early stages of the disease.<br /><br />Researchers have described two major types of age-related macular degeneration, known as the dry form and the wet form. The dry form is much more common, accounting for 85 to 90 percent of all cases of age-related macular degeneration. It is characterized by a buildup of yellowish deposits called drusen beneath the retina and vision loss that worsens slowly over time. The most advanced stage of dry age-related macular degeneration is known as geographic atrophy, in which areas of the macula waste away (atrophy), resulting in severe vision loss. Dry age-related macular degeneration typically affects vision in both eyes, although vision loss often occurs in one eye before the other.<br /><br />In 10 to 15 percent of affected individuals, the dry form progresses to the wet form of age-related macular degeneration. The wet form is characterized by the growth of abnormal, fragile blood vessels underneath the macula. These vessels leak blood and fluid, which damages the macula and makes central vision appear blurry and distorted. The wet form of age-related macular degeneration is associated with severe vision loss that can worsen rapidly. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0242383[DISCUI]&test_type=Clinical" ref="ncbi_uid=116576">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=116576" target="_blank" href="/omim/590050">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=116576" ref="ncbi_uid=116576">V</a></span></span><span class="TLline">Age-related macular degeneration</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1864205[DISCUI]&test_type=Clinical" ref="ncbi_uid=400475">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=400475" target="_blank" href="/omim/603075">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=400475" ref="ncbi_uid=400475">V</a></span></span><span class="TLline"><a href="/medgen/400475" ref="tree=GTR&ncbi_uid=400475&link_uid=400475" title="View MedGen record for 'Age related macular degeneration 1'">Age related macular degeneration 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3495438[DISCUI]&test_type=Clinical" ref="ncbi_uid=501183">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=501183" target="_blank" href="/omim/153800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=501183" ref="ncbi_uid=501183">V</a></span></span><span class="TLline"><a href="/medgen/501183" ref="tree=GTR&ncbi_uid=501183&link_uid=501183" title="View MedGen record for 'Age related macular degeneration 2'">Age related macular degeneration 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1853147[DISCUI]&test_type=Clinical" ref="ncbi_uid=339914">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=339914" target="_blank" href="/omim/610698">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=339914" ref="ncbi_uid=339914">V</a></span></span><span class="TLline"><a href="/medgen/339914" ref="tree=GTR&ncbi_uid=339914&link_uid=339914" title="View MedGen record for 'Age related macular degeneration 4'">Age related macular degeneration 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151063[DISCUI]&test_type=Clinical" ref="ncbi_uid=462413">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462413" target="_blank" href="/omim/613761">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462413" ref="ncbi_uid=462413">V</a></span></span><span class="TLline"><a href="/medgen/462413" ref="tree=GTR&ncbi_uid=462413&link_uid=462413" title="View MedGen record for 'Age related macular degeneration 5'">Age related macular degeneration 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151060[DISCUI]&test_type=Clinical" ref="ncbi_uid=462410">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462410" target="_blank" href="/omim/610362">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462410" ref="ncbi_uid=462410">V</a></span></span><span class="TLline"><a href="/medgen/462410" ref="tree=GTR&ncbi_uid=462410&link_uid=462410" title="View MedGen record for 'Age related macular degeneration 6'">Age related macular degeneration 6</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1857813[DISCUI]&test_type=Clinical" ref="ncbi_uid=347554">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=347554" target="_blank" href="/omim/610149">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=347554" ref="ncbi_uid=347554">V</a></span></span><span class="TLline"><a href="/medgen/347554" ref="tree=GTR&ncbi_uid=347554&link_uid=347554" title="View MedGen record for 'Age related macular degeneration 7'">Age related macular degeneration 7</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151070[DISCUI]&test_type=Clinical" ref="ncbi_uid=462420">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462420" target="_blank" href="/omim/613778">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462420" ref="ncbi_uid=462420">V</a></span></span><span class="TLline"><a href="/medgen/462420" ref="tree=GTR&ncbi_uid=462420&link_uid=462420" title="View MedGen record for 'Age related macular degeneration 8'">Age related macular degeneration 8</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1969651[DISCUI]&test_type=Clinical" ref="ncbi_uid=370717">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=370717" target="_blank" href="/omim/611378">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=370717" ref="ncbi_uid=370717">V</a></span></span><span class="TLline"><a href="/medgen/370717" ref="tree=GTR&ncbi_uid=370717&link_uid=370717" title="View MedGen record for 'Age related macular degeneration 9'">Age related macular degeneration 9</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1969108[DISCUI]&test_type=Clinical" ref="ncbi_uid=409758">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=409758" target="_blank" href="/omim/611488">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/409758" ref="tree=GTR&ncbi_uid=409758&link_uid=409758" title="View MedGen record for 'Age related macular degeneration 10'">Age related macular degeneration 10</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2677774[DISCUI]&test_type=Clinical" ref="ncbi_uid=393833">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=393833" target="_blank" href="/omim/604312">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=393833" ref="ncbi_uid=393833">V</a></span></span><span class="TLline"><a href="/medgen/393833" ref="tree=GTR&ncbi_uid=393833&link_uid=393833" title="View MedGen record for 'Age related macular degeneration 11'">Age related macular degeneration 11</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3151079[DISCUI]&test_type=Clinical" ref="ncbi_uid=462429">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462429" target="_blank" href="/omim/613784">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=462429" ref="ncbi_uid=462429">V</a></span></span><span class="TLline"><a href="/medgen/462429" ref="tree=GTR&ncbi_uid=462429&link_uid=462429" title="View MedGen record for 'Age related macular degeneration 12'">Age related macular degeneration 12</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3809523[DISCUI]&test_type=Clinical" ref="ncbi_uid=815853">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=815853" target="_blank" href="/omim/615439">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=815853" ref="ncbi_uid=815853">V</a></span></span><span class="TLline"><a href="/medgen/815853" ref="tree=GTR&ncbi_uid=815853&link_uid=815853" title="View MedGen record for 'Age related macular degeneration 13'">Age related macular degeneration 13</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3809653[DISCUI]&test_type=Clinical" ref="ncbi_uid=815983">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=815983" target="_blank" href="/omim/615489">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=815983" ref="ncbi_uid=815983">V</a></span></span><span class="TLline"><a href="/medgen/815983" ref="tree=GTR&ncbi_uid=815983&link_uid=815983" title="View MedGen record for 'Age related macular degeneration 14'">Age related macular degeneration 14</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3810042[DISCUI]&test_type=Clinical" ref="ncbi_uid=816372">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=816372" target="_blank" href="/omim/615591">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=816372" ref="ncbi_uid=816372">V</a></span></span><span class="TLline"><a href="/medgen/816372" ref="tree=GTR&ncbi_uid=816372&link_uid=816372" title="View MedGen record for 'Age related macular degeneration 15'">Age related macular degeneration 15</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1837187[DISCUI]&test_type=Clinical" ref="ncbi_uid=373276">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=373276" target="_blank" href="/omim/604580">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=373276" ref="ncbi_uid=373276">V</a></span></span><span class="TLline"><a href="/medgen/373276" ref="tree=GTR&ncbi_uid=373276&link_uid=373276" title="View MedGen record for 'Macular degeneration, age-related, 3'">Macular degeneration, age-related, 3</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/868526" ref="tree=MeSH" title="MedGen record for Abnormal eye morphology">Abnormal eye morphology</a></span><ul><li><span class="TLline"><a href="/medgen/870893" ref="tree=MeSH" title="MedGen record for Abnormal posterior eye segment morphology">Abnormal posterior eye segment morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871316" ref="tree=MeSH" title="MedGen record for Abnormal fundus morphology">Abnormal fundus morphology</a></span><ul><li><span class="TLline"><a href="/medgen/472885" ref="tree=MeSH" title="MedGen record for Abnormal retinal morphology">Abnormal retinal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1624166" ref="tree=MeSH" title="MedGen record for Abnormal macular morphology">Abnormal macular morphology</a></span><ul><li><span class="TLline"><a href="/medgen/7434" ref="tree=MeSH" title="MedGen record for Macular degeneration">Macular degeneration</a></span><ul><li><span class="matched_ds">Age-related macular degeneration</span><ul><li><span class="TLline"><a href="/medgen/400475" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 1">Age related macular degeneration 1</a></span></li><li><span class="TLline"><a href="/medgen/501183" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 2">Age related macular degeneration 2</a></span></li><li><span class="TLline"><a href="/medgen/339914" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 4">Age related macular degeneration 4</a></span></li><li><span class="TLline"><a href="/medgen/462413" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 5">Age related macular degeneration 5</a></span></li><li><span class="TLline"><a href="/medgen/462410" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 6">Age related macular degeneration 6</a></span></li><li><span class="TLline"><a href="/medgen/347554" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 7">Age related macular degeneration 7</a></span></li><li><span class="TLline"><a href="/medgen/462420" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 8">Age related macular degeneration 8</a></span></li><li><span class="TLline"><a href="/medgen/370717" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 9">Age related macular degeneration 9</a></span></li><li><span class="TLline"><a href="/medgen/409758" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 10">Age related macular degeneration 10</a></span></li><li><span class="TLline"><a href="/medgen/393833" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 11">Age related macular degeneration 11</a></span></li><li><span class="TLline"><a href="/medgen/462429" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 12">Age related macular degeneration 12</a></span></li><li><span class="TLline"><a href="/medgen/815853" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 13">Age related macular degeneration 13</a></span></li><li><span class="TLline"><a href="/medgen/815983" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 14">Age related macular degeneration 14</a></span></li><li><span class="TLline"><a href="/medgen/816372" ref="tree=MeSH" title="MedGen record for Age related macular degeneration 15">Age related macular degeneration 15</a></span></li><li><span class="TLline"><a href="/medgen/373276" ref="tree=MeSH" title="MedGen record for Macular degeneration, age-related, 3">Macular degeneration, age-related, 3</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/37737509">Treatment of dry age-related macular degeneration: A review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Girgis S,
|
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Lee LR</span><br />
|
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<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2023 Nov;51(8):835-852.
|
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Epub 2023 Sep 22
|
||
doi: 10.1111/ceo.14294.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37737509" target="_blank">37737509</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/34130290">Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Flores R,
|
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Carneiro Â,
|
||
Vieira M,
|
||
Tenreiro S,
|
||
Seabra MC</span><br />
|
||
<span class="medgenPMjournal">Ophthalmologica</span>
|
||
2021;244(6):495-511.
|
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Epub 2021 Jun 15
|
||
doi: 10.1159/000517520.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34130290" target="_blank">34130290</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/33087239">The Diagnosis and Treatment of Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stahl A</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2020 Jul 20;117(29-30):513-520.
|
||
doi: 10.3238/arztebl.2020.0513.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33087239" target="_blank">33087239</a><a href="/pmc/articles/PMC7588619" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22age-related%20macular%20degeneration%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1481)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23972322">CFH and ARMS2 genetic polymorphisms predict response to antioxidants and zinc in patients with age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Awh CC,
|
||
Lane AM,
|
||
Hawken S,
|
||
Zanke B,
|
||
Kim IK</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2013 Nov;120(11):2317-23.
|
||
Epub 2013 Aug 21
|
||
doi: 10.1016/j.ophtha.2013.07.039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23972322" target="_blank">23972322</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34572131">Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nashine S</span><br />
|
||
<span class="medgenPMjournal">Cells</span>
|
||
2021 Sep 19;10(9)
|
||
doi: 10.3390/cells10092483.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34572131" target="_blank">34572131</a><a href="/pmc/articles/PMC8464988" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34130290">Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flores R,
|
||
Carneiro Â,
|
||
Vieira M,
|
||
Tenreiro S,
|
||
Seabra MC</span><br />
|
||
<span class="medgenPMjournal">Ophthalmologica</span>
|
||
2021;244(6):495-511.
|
||
Epub 2021 Jun 15
|
||
doi: 10.1159/000517520.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34130290" target="_blank">34130290</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33926642">Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas CJ,
|
||
Mirza RG,
|
||
Gill MK</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2021 May;105(3):473-491.
|
||
Epub 2021 Apr 2
|
||
doi: 10.1016/j.mcna.2021.01.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33926642" target="_blank">33926642</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30303083">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mitchell P,
|
||
Liew G,
|
||
Gopinath B,
|
||
Wong TY</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 29;392(10153):1147-1159.
|
||
doi: 10.1016/S0140-6736(18)31550-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30303083" target="_blank">30303083</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19208869">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayoub T,
|
||
Patel N</span><br />
|
||
<span class="medgenPMjournal">J R Soc Med</span>
|
||
2009 Feb;102(2):56-61.
|
||
doi: 10.1258/jrsm.2009.080298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19208869" target="_blank">19208869</a><a href="/pmc/articles/PMC2642874" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9813)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36996856">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guymer RH,
|
||
Campbell TG</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2023 Apr 29;401(10386):1459-1472.
|
||
Epub 2023 Mar 27
|
||
doi: 10.1016/S0140-6736(22)02609-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36996856" target="_blank">36996856</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34130290">Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flores R,
|
||
Carneiro Â,
|
||
Vieira M,
|
||
Tenreiro S,
|
||
Seabra MC</span><br />
|
||
<span class="medgenPMjournal">Ophthalmologica</span>
|
||
2021;244(6):495-511.
|
||
Epub 2021 Jun 15
|
||
doi: 10.1159/000517520.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34130290" target="_blank">34130290</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33926642">Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas CJ,
|
||
Mirza RG,
|
||
Gill MK</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2021 May;105(3):473-491.
|
||
Epub 2021 Apr 2
|
||
doi: 10.1016/j.mcna.2021.01.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33926642" target="_blank">33926642</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30303083">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mitchell P,
|
||
Liew G,
|
||
Gopinath B,
|
||
Wong TY</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 29;392(10153):1147-1159.
|
||
doi: 10.1016/S0140-6736(18)31550-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30303083" target="_blank">30303083</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19208869">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ayoub T,
|
||
Patel N</span><br />
|
||
<span class="medgenPMjournal">J R Soc Med</span>
|
||
2009 Feb;102(2):56-61.
|
||
doi: 10.1258/jrsm.2009.080298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19208869" target="_blank">19208869</a><a href="/pmc/articles/PMC2642874" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6672)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32882310">C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jaffe GJ,
|
||
Westby K,
|
||
Csaky KG,
|
||
Monés J,
|
||
Pearlman JA,
|
||
Patel SS,
|
||
Joondeph BC,
|
||
Randolph J,
|
||
Masonson H,
|
||
Rezaei KA</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2021 Apr;128(4):576-586.
|
||
Epub 2020 Sep 1
|
||
doi: 10.1016/j.ophtha.2020.08.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32882310" target="_blank">32882310</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32205470">Age-related macular degeneration therapy: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ammar MJ,
|
||
Hsu J,
|
||
Chiang A,
|
||
Ho AC,
|
||
Regillo CD</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Ophthalmol</span>
|
||
2020 May;31(3):215-221.
|
||
doi: 10.1097/ICU.0000000000000657.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32205470" target="_blank">32205470</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29121027">Age-related macular degeneration foils drugmakers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dolgin E</span><br />
|
||
<span class="medgenPMjournal">Nat Biotechnol</span>
|
||
2017 Nov 9;35(11):1000-1001.
|
||
doi: 10.1038/nbt1117-1000.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29121027" target="_blank">29121027</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22460118">Aflibercept.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stewart MW,
|
||
Grippon S,
|
||
Kirkpatrick P</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Drug Discov</span>
|
||
2012 Mar 30;11(4):269-70.
|
||
doi: 10.1038/nrd3700.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22460118" target="_blank">22460118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22411231">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Khandhadia S,
|
||
Cherry J,
|
||
Lotery AJ</span><br />
|
||
<span class="medgenPMjournal">Adv Exp Med Biol</span>
|
||
2012;724:15-36.
|
||
doi: 10.1007/978-1-4614-0653-2_2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22411231" target="_blank">22411231</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7334)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30303083">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mitchell P,
|
||
Liew G,
|
||
Gopinath B,
|
||
Wong TY</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 29;392(10153):1147-1159.
|
||
doi: 10.1016/S0140-6736(18)31550-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30303083" target="_blank">30303083</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27914835">β-blockers and Neovascular Age-related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yeung L,
|
||
Huang TS,
|
||
Lin YH,
|
||
Hsu KH,
|
||
Chien-Chieh Huang J,
|
||
Sun CC</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2017 Mar;124(3):409-411.
|
||
Epub 2016 Nov 30
|
||
doi: 10.1016/j.ophtha.2016.10.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27914835" target="_blank">27914835</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26319344">Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mehta S</span><br />
|
||
<span class="medgenPMjournal">Prim Care</span>
|
||
2015 Sep;42(3):377-91.
|
||
doi: 10.1016/j.pop.2015.05.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26319344" target="_blank">26319344</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20696800">Age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Noble J,
|
||
Chaudhary V</span><br />
|
||
<span class="medgenPMjournal">CMAJ</span>
|
||
2010 Nov 9;182(16):1759.
|
||
Epub 2010 Aug 9
|
||
doi: 10.1503/cmaj.090378.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20696800" target="_blank">20696800</a><a href="/pmc/articles/PMC2972328" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11351954">Age-related macular degeneration. Wet type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brady LW,
|
||
Freire JE,
|
||
Yaeger TE</span><br />
|
||
<span class="medgenPMjournal">Front Radiat Ther Oncol</span>
|
||
2001;35:65-6.
|
||
doi: 10.1159/000061289.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11351954" target="_blank">11351954</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4339)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37634759">Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">He W,
|
||
Han X,
|
||
Ong JS,
|
||
Wu Y,
|
||
Hewitt AW,
|
||
Mackey DA,
|
||
Gharahkhani P,
|
||
MacGregor S</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2024 Jan;131(1):16-29.
|
||
Epub 2023 Aug 25
|
||
doi: 10.1016/j.ophtha.2023.08.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37634759" target="_blank">37634759</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36362067">Genetic Aspects of Age-Related Macular Degeneration and Their Therapeutic Potential.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stradiotto E,
|
||
Allegrini D,
|
||
Fossati G,
|
||
Raimondi R,
|
||
Sorrentino T,
|
||
Tripepi D,
|
||
Barone G,
|
||
Inforzato A,
|
||
Romano MR</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Oct 31;23(21)
|
||
doi: 10.3390/ijms232113280.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36362067" target="_blank">36362067</a><a href="/pmc/articles/PMC9653831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33315052">Metabolomics in Age-Related Macular Degeneration: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou XW,
|
||
Wang Y,
|
||
Pan CW</span><br />
|
||
<span class="medgenPMjournal">Invest Ophthalmol Vis Sci</span>
|
||
2020 Dec 1;61(14):13.
|
||
doi: 10.1167/iovs.61.14.13.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33315052" target="_blank">33315052</a><a href="/pmc/articles/PMC7735950" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31404033">A DOUBLE-MASKED, RANDOMIZED, SHAM-CONTROLLED, SINGLE-CENTER STUDY WITH PHOTOBIOMODULATION FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Markowitz SN,
|
||
Devenyi RG,
|
||
Munk MR,
|
||
Croissant CL,
|
||
Tedford SE,
|
||
Rückert R,
|
||
Walker MG,
|
||
Patino BE,
|
||
Chen L,
|
||
Nido M,
|
||
Tedford CE</span><br />
|
||
<span class="medgenPMjournal">Retina</span>
|
||
2020 Aug;40(8):1471-1482.
|
||
doi: 10.1097/IAE.0000000000002632.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31404033" target="_blank">31404033</a><a href="/pmc/articles/PMC7392581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23506967">Measuring reading performance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rubin GS</span><br />
|
||
<span class="medgenPMjournal">Vision Res</span>
|
||
2013 Sep 20;90:43-51.
|
||
Epub 2013 Mar 16
|
||
doi: 10.1016/j.visres.2013.02.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23506967" target="_blank">23506967</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5249)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35457041">Vitamin D and Ocular Diseases: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan HN,
|
||
Zhang XJ,
|
||
Ling XT,
|
||
Bui CH,
|
||
Wang YM,
|
||
Ip P,
|
||
Chu WK,
|
||
Chen LJ,
|
||
Tham CC,
|
||
Yam JC,
|
||
Pang CP</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Apr 11;23(8)
|
||
doi: 10.3390/ijms23084226.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35457041" target="_blank">35457041</a><a href="/pmc/articles/PMC9032397" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275949">Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e144-e160.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30489-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275949" target="_blank">33275949</a><a href="/pmc/articles/PMC7820391" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29032195">Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flaxman SR,
|
||
Bourne RRA,
|
||
Resnikoff S,
|
||
Ackland P,
|
||
Braithwaite T,
|
||
Cicinelli MV,
|
||
Das A,
|
||
Jonas JB,
|
||
Keeffe J,
|
||
Kempen JH,
|
||
Leasher J,
|
||
Limburg H,
|
||
Naidoo K,
|
||
Pesudovs K,
|
||
Silvester A,
|
||
Stevens GA,
|
||
Tahhan N,
|
||
Wong TY,
|
||
Taylor HR;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2017 Dec;5(12):e1221-e1234.
|
||
Epub 2017 Oct 11
|
||
doi: 10.1016/S2214-109X(17)30393-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29032195" target="_blank">29032195</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26978865">AGE-RELATED MACULAR DEGENERATION.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gheorghe A,
|
||
Mahdi L,
|
||
Musat O</span><br />
|
||
<span class="medgenPMjournal">Rom J Ophthalmol</span>
|
||
2015 Apr-Jun;59(2):74-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26978865" target="_blank">26978865</a><a href="/pmc/articles/PMC5712933" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25104651">Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wong WL,
|
||
Su X,
|
||
Li X,
|
||
Cheung CM,
|
||
Klein R,
|
||
Cheng CY,
|
||
Wong TY</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2014 Feb;2(2):e106-16.
|
||
Epub 2014 Jan 3
|
||
doi: 10.1016/S2214-109X(13)70145-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25104651" target="_blank">25104651</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Age-related%20macular%20degeneration%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (399)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
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|
||
|
||
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||
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0242383%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0242383%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0242383%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (7)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0242383%5bDISCUI%5d" target="_blank">See all (8)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/phenotypicSeries/PS603075" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=279" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Age-related%20macular%20degeneration" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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</div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22age-related%20macular%20degeneration%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Age-related%20macular%20degeneration%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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|
||
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|
||
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|
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<ul>
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<li>
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<a href="/pubmed/clinical?term=Age-related%20macular%20degeneration" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Age-related%20macular%20degeneration%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=116576" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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||
</li>
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||
<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0242383[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
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</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0242383[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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||
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||
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=116576" ref="log$=recordlinks">MeSH</a>
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=116576" ref="log$=recordlinks">OMIM</a>
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<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=116576" ref="log$=recordlinks">PMC Articles</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=116576" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=116576" ref="log$=recordlinks">PubMed (OMIM)</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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