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<meta name="keywords" content="C0238463, cancer, papillary thyroid, cancers, papillary thyroid, carcinoma, papillary thyroid, carcinomas, papillary thyroid, familial papillary thyroid carcinoma, neoplastic process, nonmedullary thyroid carcinoma, papillary, pact, papillary cancer of the thyroid, papillary cancer of the thyroid gland, papillary cancer of thyroid, papillary cancer of thyroid gland, papillary carcinoma of the thyroid, papillary carcinoma of the thyroid gland, papillary carcinoma of thyroid, papillary carcinoma of thyroid gland, papillary thyroid cancer, papillary thyroid cancers, papillary thyroid carcinoma, papillary thyroid carcinomas, papillary thyroid gland carcinoma, ptc, ptc - papillary thyroid carcinoma, thyroid cancer, papillary, thyroid cancers, papillary, thyroid carcinoma, papillary, thyroid carcinoma, papillary, somatic, thyroid carcinomas, papillary, thyroid gland papillary cancer, thyroid gland papillary carcinoma, thyroid papillary carcinoma, tpc, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The presence of a papillary adenocarcinoma of the thyroid gland." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=66773
|
||
ConceptID=C0238463
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Papillary thyroid carcinoma<span class="h1sub">(TPC; PTC; PACT)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66773</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0238463</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Familial Papillary Thyroid Carcinoma; NONMEDULLARY THYROID CARCINOMA, PAPILLARY; Thyroid carcinoma, papillary, somatic; Thyroid gland papillary carcinoma</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>PTC - papillary thyroid carcinoma (255029007); Papillary thyroid carcinoma (255029007); Papillary thyroid carcinoma (1336196002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002895">HP:0002895</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005075" target="_blank">MONDO:0005075</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/188550" target="_blank">188550</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">The presence of a papillary adenocarcinoma of the thyroid gland. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0238463[DISCUI]&test_type=Clinical" ref="ncbi_uid=66773">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=66773" target="_blank" href="/omim/188550">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=66773" ref="ncbi_uid=66773">V</a></span></span><span class="TLline">Papillary thyroid carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/122" ref="tree=MeSH" title="MedGen record for Adenocarcinoma">Adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/309935" ref="tree=MeSH" title="MedGen record for Thyroid gland adenocarcinoma">Thyroid gland adenocarcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/277876" ref="tree=MeSH" title="MedGen record for Differentiated thyroid carcinoma">Differentiated thyroid carcinoma</a></span><ul><li><span class="matched_ds">Papillary thyroid carcinoma</span><ul><li><span class="TLline"><a href="/medgen/903163" ref="tree=MeSH" title="MedGen record for Childhood Thyroid Gland Papillary Carcinoma">Childhood Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/353544" ref="tree=MeSH" title="MedGen record for Clear Cell Variant Thyroid Gland Papillary Carcinoma">Clear Cell Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/272499" ref="tree=MeSH" title="MedGen record for Columnar cell variant thyroid gland papillary carcinoma">Columnar cell variant thyroid gland papillary carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1665610" ref="tree=MeSH" title="MedGen record for Encapsulated Variant Thyroid Gland Papillary Carcinoma">Encapsulated Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/811427" ref="tree=MeSH" title="MedGen record for Follicular variant thyroid gland papillary carcinoma">Follicular variant thyroid gland papillary carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/825497" ref="tree=MeSH" title="MedGen record for Invasive Encapsulated Follicular Variant Thyroid Gland Papillary Carcinoma">Invasive Encapsulated Follicular Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1655228" ref="tree=MeSH" title="MedGen record for Invasive Follicular Variant Thyroid Gland Papillary Carcinoma">Invasive Follicular Variant Thyroid Gland Papillary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1649190" ref="tree=MeSH" title="MedGen record for Hobnail Variant Thyroid Gland Papillary Carcinoma">Hobnail Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/317865" ref="tree=MeSH" title="MedGen record for Macrofollicular Variant Thyroid Gland Papillary Carcinoma">Macrofollicular Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1650014" ref="tree=MeSH" title="MedGen record for Metastatic Thyroid Gland Papillary Carcinoma">Metastatic Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/235340" ref="tree=MeSH" title="MedGen record for Multicentric papillary thyroid carcinoma">Multicentric papillary thyroid carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/311067" ref="tree=MeSH" title="MedGen record for Oncocytic Variant Thyroid Gland Papillary Carcinoma">Oncocytic Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/313563" ref="tree=MeSH" title="MedGen record for Papillary thyroid Microcarcinoma">Papillary thyroid Microcarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1649334" ref="tree=MeSH" title="MedGen record for Recurrent Thyroid Gland Papillary Carcinoma">Recurrent Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1712759" ref="tree=MeSH" title="MedGen record for Refractory Thyroid Gland Papillary Carcinoma">Refractory Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1656998" ref="tree=MeSH" title="MedGen record for Spindle Cell Variant Thyroid Gland Papillary Carcinoma">Spindle Cell Variant Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/234416" ref="tree=MeSH" title="MedGen record for Tall cell variant thyroid gland papillary carcinoma">Tall cell variant thyroid gland papillary carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/927266" ref="tree=MeSH" title="MedGen record for Thyroid gland cribriform morular carcinoma">Thyroid gland cribriform morular carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/87218" ref="tree=MeSH" title="MedGen record for Thyroid gland diffuse sclerosing papillary carcinoma">Thyroid gland diffuse sclerosing papillary carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1647364" ref="tree=MeSH" title="MedGen record for Thyroid Gland Papillary Carcinoma by AJCC v7 Stage">Thyroid Gland Papillary Carcinoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/124521" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Papillary Carcinoma AJCC v7">Stage I Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/124522" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Papillary Carcinoma AJCC v7">Stage II Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233502" ref="tree=MeSH" title="MedGen record for Stage III Thyroid Gland Papillary Carcinoma AJCC v7">Stage III Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/75881" ref="tree=MeSH" title="MedGen record for Stage IV Thyroid Gland Papillary Carcinoma AJCC v7">Stage IV Thyroid Gland Papillary Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/857112" ref="tree=MeSH" title="MedGen record for Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7">Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857105" ref="tree=MeSH" title="MedGen record for Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7">Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/857100" ref="tree=MeSH" title="MedGen record for Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7">Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1645660" ref="tree=MeSH" title="MedGen record for Thyroid Gland Papillary Carcinoma by AJCC v8 Stage">Thyroid Gland Papillary Carcinoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1646813" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Papillary Carcinoma AJCC v8">Stage I Thyroid Gland Papillary Carcinoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1644567" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8">Stage I Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1641024" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8">Stage I Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1645084" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Papillary Carcinoma AJCC v8">Stage II Thyroid Gland Papillary Carcinoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1631900" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8">Stage II Thyroid Gland Papillary Carcinoma 55 Years and Older AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1647015" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8">Stage II Thyroid Gland Papillary Carcinoma Under 55 Years AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1641540" ref="tree=MeSH" title="MedGen record for Stage III Thyroid Gland Papillary Carcinoma AJCC v8">Stage III Thyroid Gland Papillary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1639111" ref="tree=MeSH" title="MedGen record for Stage IV Thyroid Gland Papillary Carcinoma AJCC v8">Stage IV Thyroid Gland Papillary Carcinoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1640569" ref="tree=MeSH" title="MedGen record for Stage IVA Thyroid Gland Papillary Carcinoma AJCC v8">Stage IVA Thyroid Gland Papillary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1640847" ref="tree=MeSH" title="MedGen record for Stage IVB Thyroid Gland Papillary Carcinoma AJCC v8">Stage IVB Thyroid Gland Papillary Carcinoma AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/926125" ref="tree=MeSH" title="MedGen record for Thyroid Gland Papillary Carcinoma with Fibromatosis/Fasciitis-Like/Desmoid-Type Stroma">Thyroid Gland Papillary Carcinoma with Fibromatosis/Fasciitis-Like/Desmoid-Type Stroma</a></span></li><li><span class="TLline"><a href="/medgen/569646" ref="tree=MeSH" title="MedGen record for Trabecular follicular adenocarcinoma">Trabecular follicular adenocarcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1749450" ref="tree=MeSH" title="MedGen record for Unresectable Thyroid Gland Papillary Carcinoma">Unresectable Thyroid Gland Papillary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/925508" ref="tree=MeSH" title="MedGen record for Warthin-Like Variant Thyroid Gland Papillary Carcinoma">Warthin-Like Variant Thyroid Gland Papillary Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=905&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Papillary thyroid carcinoma</span> in Orphanet.</div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_86230"><div><strong>Euthyroid goiter</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>86230</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0302859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">DICER1 tumor predisposition (DICER1) is characterized by an increased risk for pleuropulmonary blastoma (PPB), pulmonary cysts, thyroid gland neoplasia (multinodular goiter, adenomas, and/or thyroid cancer), ovarian tumors (Sertoli-Leydig cell tumor, gynandroblastoma, and sarcoma), and cystic nephroma. Less commonly observed tumors include ciliary body medulloepithelioma, nasal chondromesenchymal hamartoma, embryonal rhabdomyosarcoma, pituitary blastoma, pineoblastoma, central nervous system (CNS) sarcoma, other CNS tumors, and presacral malignant teratoid tumor. The majority of tumors occur in individuals younger than age 40 years. PPB typically presents in infants and children younger than age six years. Ovarian sex cord-stromal tumors are most often diagnosed before age 40 years. Cystic nephroma generally presents in young children but has also been reported in adolescents. Additional clinical features that may be seen include macrocephaly, ocular abnormalities, structural anomalies of the kidney and collecting system, and dental anomalies (bulbous crowns).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/86230">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_365434"><div><strong>Alagille syndrome due to a JAG1 point mutation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>365434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1956125</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Alagille syndrome (ALGS) is a multisystem disorder with a wide spectrum of clinical variability; this variability is seen even among individuals from the same family. The major clinical manifestations of ALGS are bile duct paucity on liver biopsy, cholestasis, congenital cardiac defects (primarily involving the pulmonary arteries), butterfly vertebrae, ophthalmologic abnormalities (most commonly posterior embryotoxon), and characteristic facial features. Renal abnormalities, growth failure, behavioral differences, splenomegaly, retinal changes, and vascular abnormalities may also occur.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/365434">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_398651"><div><strong>Familial adenomatous polyposis 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>398651</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2713442</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">APC-associated polyposis conditions include (classic or attenuated) familial adenomatous polyposis (FAP) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). FAP is a colorectal cancer (CRC) predisposition syndrome that can manifest in either classic or attenuated form. Classic FAP is characterized by hundreds to thousands of adenomatous colonic polyps, beginning on average at age 16 years (range 7-36 years). For those with the classic form of FAP, 95% of individuals have polyps by age 35 years; CRC is inevitable without colectomy. The mean age of CRC diagnosis in untreated individuals is 39 years (range 34-43 years). The attenuated form is characterized by multiple colonic polyps (average of 30), more proximally located polyps, and a diagnosis of CRC at a later age than in classic FAP. For those with an attenuated form, there is a 70% lifetime risk of CRC and the mean age of diagnosis is 50-55 years. Extracolonic manifestations are variably present and include polyps of the stomach and duodenum, osteomas, dental abnormalities, congenital hypertrophy of the retinal pigment epithelium (CHRPE), benign cutaneous lesions, desmoid tumors, adrenal masses, and other associated cancers. GAPPS is characterized by proximal gastric polyposis, increased risk of gastric adenocarcinoma, and no duodenal or colonic involvement in most individuals reported.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/398651">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_908796"><div><strong>Cowden syndrome 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>908796</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225179</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Cowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\n\n\nThe features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors. Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/908796">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_907624"><div><strong>Thyroid cancer, nonmedullary, 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>907624</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225293</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Nonmedullary thyroid cancer (NMTC) refers to neoplasms originating from the thyroid follicular cells and represents 80 to 95% of all thyroid cancers. Approximately 5% of NMTC occurs on the background of a familial predisposition. Although papillary thyroid carcinoma (PTC) is usually the most frequent thyroid lesion in NMTC families, multinodular goiter (MNG) and follicular thyroid adenoma also occur (summary by Pereira et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/907624">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_904175"><div><strong>Thyroid cancer, nonmedullary, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>904175</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225426</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100, Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). Follicular thyroid cancer (FTC) accounts for approximately 15% of NMTC and is defined by invasive features that result in infiltration of blood vessels and/or full penetration of the tumor capsule, in the absence of the nuclear alterations that characterize papillary carcinoma. FTC is rarely multifocal and usually does not metastasize to the regional lymph nodes but tends to spread via the bloodstream to the lung and bones. An important histologic variant of FTC is the oncocytic (Hurthle cell, oxyphilic) follicular carcinoma composed of eosinophilic cells replete with mitochondria (summary by Bonora et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/904175">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1648293"><div><strong>Thyroid cancer, nonmedullary, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648293</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4721429</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular (188470), Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a component of a familial cancer syndrome (e.g., familial adenomatous polyposis, 175100; Carney complex, 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). PTC is characterized by distinctive nuclear alterations including pseudoinclusions, grooves, and chromatin clearing. PTCs smaller than 1 cm are referred to as papillary microcarcinomas. These tumors have been identified in up to 35% of individuals at autopsy, suggesting that they may be extremely common although rarely clinically relevant. PTC can also be multifocal but is typically slow-growing with a tendency to spread to lymph nodes and usually has an excellent prognosis (summary by Bonora et al., 2010). Genetic Heterogeneity of Susceptibility to Nonmedullary Thyroid Cancer Other susceptibilities to nonmedullary thyroid cancer include NMTC2 (188470), caused by mutation in the SRGAP1 gene (606523); NMTC3 (606240), mapped to chromosome 2q21; NMTC4 (616534), caused by mutation in the FOXE1 gene (602617); and NMTC5 (616535), caused by mutation in the HABP2 gene (603924). A susceptibility locus for familial nonmedullary thyroid carcinoma with or without cell oxyphilia (TCO; 603386) has been mapped to chromosome 19p.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1648293">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_365434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alagille syndrome due to a JAG1 point mutation</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_908796" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 7</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_86230" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Euthyroid goiter</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_398651" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adenomatous polyposis 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648293" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thyroid cancer, nonmedullary, 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_904175" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thyroid cancer, nonmedullary, 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_907624" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Thyroid cancer, nonmedullary, 4</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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<div class="nl"><a target="_blank" href="/pubmed/38206595">Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bischoff LA,
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Ganly I,
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Fugazzola L,
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Buczek E,
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Faquin WC,
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Haugen BR,
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McIver B,
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McMullen CP,
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Newbold K,
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Rocke DJ,
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Russell MD,
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Ryder M,
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Sadow PM,
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Sherman E,
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Shindo M,
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Shonka DC Jr,
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Singer MC,
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Stack BC Jr,
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Wirth LJ,
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Wong RJ,
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Randolph GW</span><br />
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<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
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2024 Mar 1;150(3):265-272.
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doi: 10.1001/jamaoto.2023.4323.
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<span class="bold">PMID: </span><a href="/pubmed/38206595" target="_blank">38206595</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36326739">American Thyroid Association Guidelines and National Trends in Management of Papillary Thyroid Carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gordon AJ,
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Dublin JC,
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Patel E,
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Papazian M,
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Chow MS,
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Persky MJ,
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Jacobson AS,
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Patel KN,
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Suh I,
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Morris LGT,
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Givi B</span><br />
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<span class="medgenPMjournal">JAMA Otolaryngol Head Neck Surg</span>
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2022 Dec 1;148(12):1156-1163.
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doi: 10.1001/jamaoto.2022.3360.
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<span class="bold">PMID: </span><a href="/pubmed/36326739" target="_blank">36326739</a><a href="/pmc/articles/PMC9634599" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35948029">Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Haddad RI,
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Bischoff L,
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Ball D,
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Bernet V,
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Blomain E,
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Busaidy NL,
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Campbell M,
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Dickson P,
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Duh QY,
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Ehya H,
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Goldner WS,
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Guo T,
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Haymart M,
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Holt S,
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Hunt JP,
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Iagaru A,
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Kandeel F,
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Lamonica DM,
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Mandel S,
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Markovina S,
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McIver B,
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Raeburn CD,
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Rezaee R,
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Ridge JA,
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Roth MY,
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Scheri RP,
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Shah JP,
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Sipos JA,
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Sippel R,
|
||
Sturgeon C,
|
||
Wang TN,
|
||
Wirth LJ,
|
||
Wong RJ,
|
||
Yeh M,
|
||
Cassara CJ,
|
||
Darlow S</span><br />
|
||
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
|
||
2022 Aug;20(8):925-951.
|
||
doi: 10.6004/jnccn.2022.0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35948029" target="_blank">35948029</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22papillary%20thyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (310)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng230" target="_blank">UK NICE Guideline NG230, Thyroid cancer: assessment and management</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389271">Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389271" target="_blank">26389271</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37604507">Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao X,
|
||
Yang Y,
|
||
Wang Y,
|
||
Huang Y</span><br />
|
||
<span class="medgenPMjournal">Int J Hyperthermia</span>
|
||
2023 Dec;40(1):2244713.
|
||
doi: 10.1080/02656736.2023.2244713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37604507" target="_blank">37604507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670979">Radioactive Iodine for Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan WWL,
|
||
Kwong DLW</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:225-241.
|
||
doi: 10.1007/978-1-0716-2505-7_16.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670979" target="_blank">35670979</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670964">Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lam AK</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:1-15.
|
||
doi: 10.1007/978-1-0716-2505-7_1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670964" target="_blank">35670964</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35282434">Hashimoto's Thyroiditis: A "Double-Edged Sword" in Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xu J,
|
||
Ding K,
|
||
Mu L,
|
||
Huang J,
|
||
Ye F,
|
||
Peng Y,
|
||
Guo C,
|
||
Ren C</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:801925.
|
||
Epub 2022 Feb 24
|
||
doi: 10.3389/fendo.2022.801925.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35282434" target="_blank">35282434</a><a href="/pmc/articles/PMC8907134" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4264)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36960399">Editorial: Recent advances in papillary thyroid carcinoma: Progression, treatment and survival predictors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Volpi EM,
|
||
Ramirez-Ortega MC,
|
||
Carrillo JF</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1163309.
|
||
Epub 2023 Mar 7
|
||
doi: 10.3389/fendo.2023.1163309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36960399" target="_blank">36960399</a><a href="/pmc/articles/PMC10028267" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670967">Thyroidectomy for Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lo CY</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:39-56.
|
||
doi: 10.1007/978-1-0716-2505-7_4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670967" target="_blank">35670967</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670964">Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lam AK</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:1-15.
|
||
doi: 10.1007/978-1-0716-2505-7_1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670964" target="_blank">35670964</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34030870">Predicting nodal metastases in papillary thyroid carcinoma using artificial intelligence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Esce AR,
|
||
Redemann JP,
|
||
Sanchez AC,
|
||
Olson GT,
|
||
Hanson JA,
|
||
Agarwal S,
|
||
Boyd NH,
|
||
Martin DR</span><br />
|
||
<span class="medgenPMjournal">Am J Surg</span>
|
||
2021 Nov;222(5):952-958.
|
||
Epub 2021 May 13
|
||
doi: 10.1016/j.amjsurg.2021.05.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34030870" target="_blank">34030870</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21221869">Papillary thyroid carcinoma variants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lloyd RV,
|
||
Buehler D,
|
||
Khanafshar E</span><br />
|
||
<span class="medgenPMjournal">Head Neck Pathol</span>
|
||
2011 Mar;5(1):51-6.
|
||
Epub 2011 Jan 8
|
||
doi: 10.1007/s12105-010-0236-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21221869" target="_blank">21221869</a><a href="/pmc/articles/PMC3037461" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4119)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37604507">Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao X,
|
||
Yang Y,
|
||
Wang Y,
|
||
Huang Y</span><br />
|
||
<span class="medgenPMjournal">Int J Hyperthermia</span>
|
||
2023 Dec;40(1):2244713.
|
||
doi: 10.1080/02656736.2023.2244713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37604507" target="_blank">37604507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670979">Radioactive Iodine for Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan WWL,
|
||
Kwong DLW</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:225-241.
|
||
doi: 10.1007/978-1-0716-2505-7_16.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670979" target="_blank">35670979</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35333737">Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Waguespack SG,
|
||
Drilon A,
|
||
Lin JJ,
|
||
Brose MS,
|
||
McDermott R,
|
||
Almubarak M,
|
||
Bauman J,
|
||
Casanova M,
|
||
Krishnamurthy A,
|
||
Kummar S,
|
||
Leyvraz S,
|
||
Oh DY,
|
||
Park K,
|
||
Sohal D,
|
||
Sherman E,
|
||
Norenberg R,
|
||
Silvertown JD,
|
||
Brega N,
|
||
Hong DS,
|
||
Cabanillas ME</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2022 Apr 29;186(6):631-643.
|
||
doi: 10.1530/EJE-21-1259.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35333737" target="_blank">35333737</a><a href="/pmc/articles/PMC9066591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30205650">Nanostructures: between natural environment and medical practice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Trovato MC,
|
||
Andronico D,
|
||
Sciacchitano S,
|
||
Ruggeri RM,
|
||
Picerno I,
|
||
Di Pietro A,
|
||
Visalli G</span><br />
|
||
<span class="medgenPMjournal">Rev Environ Health</span>
|
||
2018 Sep 25;33(3):295-307.
|
||
doi: 10.1515/reveh-2017-0036.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30205650" target="_blank">30205650</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3306936">Papillary thyroid carcinoma: factors influencing prognosis and current therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzaferri EL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
1987 Sep;14(3):315-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3306936" target="_blank">3306936</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1223)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39298113">Serum microRNA-146a-5p and microRNA-221-3p as potential clinical biomarkers for papillary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Verrienti A,
|
||
Pecce V,
|
||
Grani G,
|
||
Del Gatto V,
|
||
Barp S,
|
||
Maranghi M,
|
||
Giacomelli L,
|
||
Di Gioia C,
|
||
Biffoni M,
|
||
Filetti S,
|
||
Durante C,
|
||
Sponziello M</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2025 Mar;48(3):619-631.
|
||
Epub 2024 Sep 19
|
||
doi: 10.1007/s40618-024-02467-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39298113" target="_blank">39298113</a><a href="/pmc/articles/PMC11876262" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35132899">Thyroid Cancer Incidence and Mortality Trends in the United States: 2000-2018.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Megwalu UC,
|
||
Moon PK</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2022 May;32(5):560-570.
|
||
Epub 2022 Mar 15
|
||
doi: 10.1089/thy.2021.0662.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35132899" target="_blank">35132899</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35048734">Thermal ablation for papillary thyroid microcarcinoma located in the isthmus: a study with 3 years of follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng L,
|
||
Liu FY,
|
||
Yu J,
|
||
Cheng ZG,
|
||
Yu XL,
|
||
Dong XC,
|
||
Han ZY,
|
||
Liang P</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2022 Feb;18(4):471-480.
|
||
Epub 2022 Jan 20
|
||
doi: 10.2217/fon-2021-0463.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35048734" target="_blank">35048734</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28079945">Systematic review of site distribution of bone metastases in differentiated thyroid cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Osorio M,
|
||
Moubayed SP,
|
||
Su H,
|
||
Urken ML</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2017 Apr;39(4):812-818.
|
||
Epub 2017 Jan 11
|
||
doi: 10.1002/hed.24655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28079945" target="_blank">28079945</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3306936">Papillary thyroid carcinoma: factors influencing prognosis and current therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzaferri EL</span><br />
|
||
<span class="medgenPMjournal">Semin Oncol</span>
|
||
1987 Sep;14(3):315-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3306936" target="_blank">3306936</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3654)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36960399">Editorial: Recent advances in papillary thyroid carcinoma: Progression, treatment and survival predictors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Volpi EM,
|
||
Ramirez-Ortega MC,
|
||
Carrillo JF</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1163309.
|
||
Epub 2023 Mar 7
|
||
doi: 10.3389/fendo.2023.1163309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36960399" target="_blank">36960399</a><a href="/pmc/articles/PMC10028267" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670970">Histopathological Assessment for Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lam AK</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:93-108.
|
||
doi: 10.1007/978-1-0716-2505-7_7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670970" target="_blank">35670970</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35670967">Thyroidectomy for Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lo CY</span><br />
|
||
<span class="medgenPMjournal">Methods Mol Biol</span>
|
||
2022;2534:39-56.
|
||
doi: 10.1007/978-1-0716-2505-7_4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35670967" target="_blank">35670967</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33382428">Pitfalls in RET Fusion Detection Using Break-Apart FISH Probes in Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu Y,
|
||
Wu S,
|
||
Zhou L,
|
||
Guo Y,
|
||
Zeng X</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2021 Mar 25;106(4):1129-1138.
|
||
doi: 10.1210/clinem/dgaa913.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33382428" target="_blank">33382428</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27214083">Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Daniels GH</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2016 Jul;26(7):872-4.
|
||
Epub 2016 Jun 22
|
||
doi: 10.1089/thy.2016.0244.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27214083" target="_blank">27214083</a><a href="/pmc/articles/PMC4939382" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2900)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37604507">Efficacy and safety of ultrasound-guided radiofrequency, microwave and laser ablation for the treatment of T1N0M0 papillary thyroid carcinoma on a large scale: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gao X,
|
||
Yang Y,
|
||
Wang Y,
|
||
Huang Y</span><br />
|
||
<span class="medgenPMjournal">Int J Hyperthermia</span>
|
||
2023 Dec;40(1):2244713.
|
||
doi: 10.1080/02656736.2023.2244713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37604507" target="_blank">37604507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35647194">Risk and Prognostic Factors for BRAF(V600E) Mutations in Papillary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wei X,
|
||
Wang X,
|
||
Xiong J,
|
||
Li C,
|
||
Liao Y,
|
||
Zhu Y,
|
||
Mao J</span><br />
|
||
<span class="medgenPMjournal">Biomed Res Int</span>
|
||
2022;2022:9959649.
|
||
Epub 2022 May 18
|
||
doi: 10.1155/2022/9959649.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35647194" target="_blank">35647194</a><a href="/pmc/articles/PMC9132653" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34625988">The value of contrast-enhanced ultrasound for the diagnosis of metastatic cervical lymph nodes of papillary thyroid carcinoma: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li QL,
|
||
Ma T,
|
||
Wang ZJ,
|
||
Huang L,
|
||
Liu W,
|
||
Chen M,
|
||
Sang T,
|
||
Ren XG,
|
||
Tong J,
|
||
Cao CL,
|
||
Dong J,
|
||
Li J</span><br />
|
||
<span class="medgenPMjournal">J Clin Ultrasound</span>
|
||
2022 Jan;50(1):60-69.
|
||
Epub 2021 Oct 8
|
||
doi: 10.1002/jcu.23073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34625988" target="_blank">34625988</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32477264">Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao J,
|
||
Zhang Q,
|
||
Zhang H,
|
||
Zheng K,
|
||
Wang R,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:265.
|
||
Epub 2020 May 15
|
||
doi: 10.3389/fendo.2020.00265.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32477264" target="_blank">32477264</a><a href="/pmc/articles/PMC7242632" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26335228">External beam radiotherapy in differentiated thyroid carcinoma: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fussey JM,
|
||
Crunkhorn R,
|
||
Tedla M,
|
||
Weickert MO,
|
||
Mehanna H</span><br />
|
||
<span class="medgenPMjournal">Head Neck</span>
|
||
2016 Apr;38 Suppl 1:E2297-305.
|
||
Epub 2015 Sep 3
|
||
doi: 10.1002/hed.24218.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26335228" target="_blank">26335228</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Papillary%20thyroid%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (119)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
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|
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|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
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|
||
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|
||
<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0238463%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (18)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238463%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (22)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238463%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0238463%5bDISCUI%5d" target="_blank">See all (26)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Papillary%20thyroid%20carcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22papillary%20thyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Papillary%20thyroid%20carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024</div></li><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng230">NICE, 2022</a><div>UK NICE Guideline NG230, Thyroid cancer: assessment and management</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Thyroid+cancer%2C+papillary/7108" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/thyroid_cancer_nonmedullary_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Papillary%20thyroid%20carcinoma" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/12027/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=66773" ref="log$=recordlinks">ClinVar</a>
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<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0238463[DISCUI]" ref="log$=recordlinks">GTR</a>
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