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<meta name="keywords" content="C0234853, facial grimace, facial grimacing, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Facial grimacing is characterized by a distorted, distressed look. The brow is more wrinkled, as is the area around the mouth. Eyes may be squeezed shut." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=65891
|
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ConceptID=C0234853
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Facial grimacing</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65891</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0234853</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Facial grimace</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Facial grimacing (37126005)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0000273">HP:0000273</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Facial grimacing is characterized by a distorted, distressed look. The brow is more wrinkled, as is the area around the mouth. Eyes may be squeezed shut. [from LNC]</div>
|
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</div>
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||
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Facial grimacing</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867442" ref="tree=MeSH" title="MedGen record for Abnormality of head or neck">Abnormality of head or neck</a></span><ul><li><span class="TLline"><a href="/medgen/867438" ref="tree=MeSH" title="MedGen record for Abnormality of the head">Abnormality of the head</a></span><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/870752" ref="tree=MeSH" title="MedGen record for Abnormal facial expression">Abnormal facial expression</a></span><ul><li><span class="TLline"><a href="/medgen/870758" ref="tree=MeSH" title="MedGen record for Disturbance of facial expression">Disturbance of facial expression</a></span><ul><li><span class="matched_ds">Facial grimacing</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_41345"><div><strong>5p partial monosomy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41345</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010314</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cri-du-chat syndrome was first described by Lejeune et al. (1963) as a hereditary congenital syndrome associated with deletion of part of the short arm of chromosome 5. The deletions can vary in size from extremely small and involving only band 5p15.2 to the entire short arm. Although the majority of deletions arise as new mutations, approximately 12% result from unbalanced segregation of translocations or recombination involving a pericentric inversion in one of the parents.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41345">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_6708"><div><strong>Pigmentary pallidal degeneration</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6708</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0018523</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pantothenate kinase-associated neurodegeneration (PKAN) is a type of neurodegeneration with brain iron accumulation (NBIA). The phenotypic spectrum of PKAN includes classic PKAN and atypical PKAN. Classic PKAN is characterized by early-childhood onset of progressive dystonia, dysarthria, rigidity, and choreoathetosis. Pigmentary retinal degeneration is common. Atypical PKAN is characterized by later onset (age >10 years), prominent speech defects, psychiatric disturbances, and more gradual progression of disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6708">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_374113"><div><strong>Striatonigral degeneration, infantile, mitochondrial</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374113</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839022</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374113">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767434"><div><strong>Urofacial syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554520</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Urofacial syndrome (UFS; also known as Ochoa syndrome) is characterized by prenatal or childhood onset of urinary bladder voiding dysfunction, abnormal facial movement with expression (resulting from abnormal co-contraction of the corners of the mouth and eyes), and often bowel dysfunction (constipation and/or encopresis). Bladder voiding dysfunction can present before birth as megacystis. In infancy and later childhood, UFS can present with a poor urinary stream and dribbling incontinence; incomplete bladder emptying can lead to urinary infection with progressive kidney failure. Investigations after birth can show abnormal bladder contractility and vesicoureteral reflux of urine into the ureter and renal pelvis. Nocturnal lagophthalmos (incomplete closing of the eyes during sleep) has also been documented.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767434">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1631383"><div><strong>Paroxysmal nonkinesigenic dyskinesia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1631383</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551506</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial paroxysmal nonkinesigenic dyskinesia (PNKD) is characterized by unilateral or bilateral involuntary movements. Attacks are typically precipitated by coffee, tea, or alcohol; they can also be triggered by excitement, stress, or fatigue, or can be spontaneous. Attacks involve dystonic posturing with choreic and ballistic movements, may be accompanied by a preceding aura, occur while the individual is awake, and are not associated with seizures. Attacks last minutes to hours and rarely occur more than once per day. Attack frequency, duration, severity, and combinations of symptoms vary within and among families. Age of onset is typically in childhood or early teens but can be as late as age 50 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1631383">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1639327"><div><strong>Rubinstein-Taybi syndrome due to CREBBP mutations</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1639327</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and halluces, short stature, and moderate-to-severe intellectual disability. Characteristic craniofacial features include downslanted palpebral fissures, low-hanging columella, high palate, grimacing smile, and talon cusps. Prenatal growth is often normal, then height, weight, and head circumference percentiles rapidly drop in the first few months of life. Short stature is typical in adulthood. Obesity may develop in childhood or adolescence. Average IQ ranges between 35 and 50; however, developmental outcome varies considerably. Some individuals with EP300-related RSTS have normal intellect. Additional features include ocular abnormalities, hearing loss, respiratory difficulties, congenital heart defects, renal abnormalities, cryptorchidism, feeding problems, recurrent infections, and severe constipation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1639327">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1727046"><div><strong>Intellectual developmental disorder with paroxysmal dyskinesia or seizures</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1727046</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436894</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Intellectual developmental disorder with paroxysmal dyskinesia or seizures (IDDPADS) is an autosomal recessive complex neurologic disorder characterized by global developmental delay with impaired intellectual development and language delay. In addition, most patients develop a paroxysmal hyperkinetic movement disorder in the first months or years of life manifest as sudden falls or backward propulsion, eye or head deviation, and dystonic limb posturing followed by chorea and dyskinetic movements. The episodes are pharmacoresistant to anticonvulsant medication. EEG may show interictal abnormalities, but are usually not consistent with epilepsy. However, some patients may also develop epileptic seizures or only have seizures without a movement disorder (summary by Doummar et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1727046">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_41345" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">5p partial monosomy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1727046" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder with paroxysmal dyskinesia or seizures</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1631383" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Paroxysmal nonkinesigenic dyskinesia 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_6708" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pigmentary pallidal degeneration</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1639327" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rubinstein-Taybi syndrome due to CREBBP mutations</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_374113" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Striatonigral degeneration, infantile, mitochondrial</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Urofacial syndrome 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34963377">Factors influencing postoperative pain management among nurses in selected district hospitals in Ghana.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Menlah A,
|
||
OseiAppiah E,
|
||
Garti I,
|
||
Frempomaa Agyare D</span><br />
|
||
<span class="medgenPMjournal">J Perioper Pract</span>
|
||
2023 Jul-Aug;33(7-8):223-232.
|
||
Epub 2021 Dec 29
|
||
doi: 10.1177/17504589211064039.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34963377" target="_blank">34963377</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22588042">A review of the evaluation and management of velopharyngeal insufficiency in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruda JM,
|
||
Krakovitz P,
|
||
Rose AS</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2012 Jun;45(3):653-69, viii.
|
||
doi: 10.1016/j.otc.2012.03.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22588042" target="_blank">22588042</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11188470">Nurses' perceptions of pain assessment and treatment in the cognitively impaired elderly. It's not a guessing game.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kovach CR,
|
||
Griffie J,
|
||
Muchka S,
|
||
Noonan PE,
|
||
Weissman DE</span><br />
|
||
<span class="medgenPMjournal">Clin Nurse Spec</span>
|
||
2000 Sep;14(5):215-20.
|
||
doi: 10.1097/00002800-200009000-00011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11188470" target="_blank">11188470</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22facial%20grimacing%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32799664">Comparing Quality of Life and Perceptual Speech Ratings in Children With Cleft Palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pedersen HM,
|
||
Goodie PA,
|
||
Braden MN,
|
||
Thibeault SL</span><br />
|
||
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
|
||
2021 Feb;58(2):139-145.
|
||
Epub 2020 Aug 17
|
||
doi: 10.1177/1055665620949435.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32799664" target="_blank">32799664</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30616057">Facial grimacing and clinical correlates in spinocerebellar ataxia type 3.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rezende Filho FM,
|
||
Vale TC,
|
||
Pedroso JL,
|
||
Braga-Neto P,
|
||
Barsottini OG</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
2019 Feb 15;397:138-140.
|
||
Epub 2019 Jan 2
|
||
doi: 10.1016/j.jns.2019.01.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30616057" target="_blank">30616057</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16962342">How nursing personnel judge patients' pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Igier V,
|
||
Mullet E,
|
||
Sorum PC</span><br />
|
||
<span class="medgenPMjournal">Eur J Pain</span>
|
||
2007 Jul;11(5):542-50.
|
||
Epub 2006 Sep 7
|
||
doi: 10.1016/j.ejpain.2006.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16962342" target="_blank">16962342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1940132">Unusual variants of infantile spasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Donat JF,
|
||
Wright FS</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
1991 Oct;6(4):313-8.
|
||
doi: 10.1177/088307389100600405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1940132" target="_blank">1940132</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6587299">The nonsurgical treatment of microstomia in scleroderma: a pilot study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naylor WP,
|
||
Douglass CW,
|
||
Mix E</span><br />
|
||
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol</span>
|
||
1984 May;57(5):508-11.
|
||
doi: 10.1016/0030-4220(84)90309-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6587299" target="_blank">6587299</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (35)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37580161">Clinical Reasoning: A Young Adult With New Seizures and Chapeau de Gendarme.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Valdrighi A,
|
||
Douglas AG,
|
||
Knowlton RC,
|
||
Shah M,
|
||
Kleen JK</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2023 Oct 31;101(18):e1821-e1827.
|
||
Epub 2023 Aug 14
|
||
doi: 10.1212/WNL.0000000000207827.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37580161" target="_blank">37580161</a><a href="/pmc/articles/PMC10634645" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22588042">A review of the evaluation and management of velopharyngeal insufficiency in children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruda JM,
|
||
Krakovitz P,
|
||
Rose AS</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2012 Jun;45(3):653-69, viii.
|
||
doi: 10.1016/j.otc.2012.03.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22588042" target="_blank">22588042</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20627778">Partial epilepsy presenting as focal atonic seizure: a case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao J,
|
||
Afra P,
|
||
Adamolekun B</span><br />
|
||
<span class="medgenPMjournal">Seizure</span>
|
||
2010 Jul;19(6):326-9.
|
||
doi: 10.1016/j.seizure.2010.04.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20627778" target="_blank">20627778</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1940132">Unusual variants of infantile spasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Donat JF,
|
||
Wright FS</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
1991 Oct;6(4):313-8.
|
||
doi: 10.1177/088307389100600405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1940132" target="_blank">1940132</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6743065">Paroxysmal dystonia as the initial manifestation of multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berger JR,
|
||
Sheremata WA,
|
||
Melamed E</span><br />
|
||
<span class="medgenPMjournal">Arch Neurol</span>
|
||
1984 Jul;41(7):747-50.
|
||
doi: 10.1001/archneur.1984.04050180069020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6743065" target="_blank">6743065</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (41)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26645550">Brain measures of nociception using near-infrared spectroscopy in patients undergoing routine screening colonoscopy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Becerra L,
|
||
Aasted CM,
|
||
Boas DA,
|
||
George E,
|
||
Yücel MA,
|
||
Kussman BD,
|
||
Kelsey P,
|
||
Borsook D</span><br />
|
||
<span class="medgenPMjournal">Pain</span>
|
||
2016 Apr;157(4):840-848.
|
||
doi: 10.1097/j.pain.0000000000000446.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26645550" target="_blank">26645550</a><a href="/pmc/articles/PMC4794375" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22999776">Ketamine-induced catalepsy during adult sedation in the Emergency Department.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heitz CR,
|
||
Bence JR</span><br />
|
||
<span class="medgenPMjournal">J Emerg Med</span>
|
||
2013 Feb;44(2):e243-5.
|
||
Epub 2012 Sep 19
|
||
doi: 10.1016/j.jemermed.2012.07.063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22999776" target="_blank">22999776</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18316230">Dystonic frowning without blepharospasm.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hirota N,
|
||
Hirota M,
|
||
Mezaki T</span><br />
|
||
<span class="medgenPMjournal">Parkinsonism Relat Disord</span>
|
||
2008 Nov;14(7):579-80.
|
||
Epub 2008 Mar 3
|
||
doi: 10.1016/j.parkreldis.2007.12.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18316230" target="_blank">18316230</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15226521">Effects of age, gender and holding on pain response during infant immunization.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ipp M,
|
||
Taddio A,
|
||
Goldbach M,
|
||
Ben David S,
|
||
Stevens B,
|
||
Koren G</span><br />
|
||
<span class="medgenPMjournal">Can J Clin Pharmacol</span>
|
||
2004 Spring;11(1):e2-7.
|
||
Epub 2004 Apr 1
|
||
<span class="bold">PMID: </span><a href="/pubmed/15226521" target="_blank">15226521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6587299">The nonsurgical treatment of microstomia in scleroderma: a pilot study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Naylor WP,
|
||
Douglass CW,
|
||
Mix E</span><br />
|
||
<span class="medgenPMjournal">Oral Surg Oral Med Oral Pathol</span>
|
||
1984 May;57(5):508-11.
|
||
doi: 10.1016/0030-4220(84)90309-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6587299" target="_blank">6587299</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22512666">Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Willhite CC,
|
||
Ball GL,
|
||
McLellan CJ</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Toxicol</span>
|
||
2012 May;42(5):358-442.
|
||
doi: 10.3109/10408444.2012.674101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22512666" target="_blank">22512666</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20187883">Stereotypic movement disorder: easily missed.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Freeman RD,
|
||
Soltanifar A,
|
||
Baer S</span><br />
|
||
<span class="medgenPMjournal">Dev Med Child Neurol</span>
|
||
2010 Aug;52(8):733-8.
|
||
Epub 2010 Feb 24
|
||
doi: 10.1111/j.1469-8749.2010.03627.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20187883" target="_blank">20187883</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11446407">Three new European cases of urofacial (Ochoa) syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Minaur S,
|
||
Oliver F,
|
||
Yanez JM,
|
||
Soriano JR,
|
||
Quinn F,
|
||
Reardon W</span><br />
|
||
<span class="medgenPMjournal">Clin Dysmorphol</span>
|
||
2001 Jul;10(3):165-70.
|
||
doi: 10.1097/00019605-200107000-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11446407" target="_blank">11446407</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10619284">Catatonia, autism, and ECT.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaw FK,
|
||
Bates GD,
|
||
Murali V,
|
||
Bentham P</span><br />
|
||
<span class="medgenPMjournal">Dev Med Child Neurol</span>
|
||
1999 Dec;41(12):843-5.
|
||
doi: 10.1017/s001216229900167x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10619284" target="_blank">10619284</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1940132">Unusual variants of infantile spasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Donat JF,
|
||
Wright FS</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
1991 Oct;6(4):313-8.
|
||
doi: 10.1177/088307389100600405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1940132" target="_blank">1940132</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32799664">Comparing Quality of Life and Perceptual Speech Ratings in Children With Cleft Palate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pedersen HM,
|
||
Goodie PA,
|
||
Braden MN,
|
||
Thibeault SL</span><br />
|
||
<span class="medgenPMjournal">Cleft Palate Craniofac J</span>
|
||
2021 Feb;58(2):139-145.
|
||
Epub 2020 Aug 17
|
||
doi: 10.1177/1055665620949435.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32799664" target="_blank">32799664</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20187883">Stereotypic movement disorder: easily missed.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Freeman RD,
|
||
Soltanifar A,
|
||
Baer S</span><br />
|
||
<span class="medgenPMjournal">Dev Med Child Neurol</span>
|
||
2010 Aug;52(8):733-8.
|
||
Epub 2010 Feb 24
|
||
doi: 10.1111/j.1469-8749.2010.03627.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20187883" target="_blank">20187883</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17574701">Measuring facial grimacing for quantifying patient agitation in critical care.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Becouze P,
|
||
Hann CE,
|
||
Chase JG,
|
||
Shaw GM</span><br />
|
||
<span class="medgenPMjournal">Comput Methods Programs Biomed</span>
|
||
2007 Aug;87(2):138-47.
|
||
Epub 2007 Jun 15
|
||
doi: 10.1016/j.cmpb.2007.05.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17574701" target="_blank">17574701</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16962342">How nursing personnel judge patients' pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Igier V,
|
||
Mullet E,
|
||
Sorum PC</span><br />
|
||
<span class="medgenPMjournal">Eur J Pain</span>
|
||
2007 Jul;11(5):542-50.
|
||
Epub 2006 Sep 7
|
||
doi: 10.1016/j.ejpain.2006.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16962342" target="_blank">16962342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15226521">Effects of age, gender and holding on pain response during infant immunization.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ipp M,
|
||
Taddio A,
|
||
Goldbach M,
|
||
Ben David S,
|
||
Stevens B,
|
||
Koren G</span><br />
|
||
<span class="medgenPMjournal">Can J Clin Pharmacol</span>
|
||
2004 Spring;11(1):e2-7.
|
||
Epub 2004 Apr 1
|
||
<span class="bold">PMID: </span><a href="/pubmed/15226521" target="_blank">15226521</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/9445511">A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taddio A,
|
||
Ohlsson A,
|
||
Einarson TR,
|
||
Stevens B,
|
||
Koren G</span><br />
|
||
<span class="medgenPMjournal">Pediatrics</span>
|
||
1998 Feb;101(2):E1.
|
||
doi: 10.1542/peds.101.2.e1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9445511" target="_blank">9445511</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Facial%20grimacing%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Facial%20grimacing" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22facial%20grimacing%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Facial%20grimacing%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Facial%20grimacing" target="_blank">MedlinePlus</a></li></ul></div>
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=65891" ref="log$=recordlinks">ClinVar</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67ce917db15b832ebcff0439">Facial grimacing</a>
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<div class="ralinkpop offscreen_noflow">Facial grimacing<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67ce917cb15b832ebcfef61b">C0234853[conceptid] <span class="number">(1)</span></a>
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<div class="ralinkpop offscreen_noflow">C5193066[trait identifier] AND "Centre for Mendelian Genomics, University Medical Centre Ljubljana"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67ce9179f4a390645e2e5c34">C1306710[trait identifier] AND "Centre for Mendelian Genomics, Un... <span class="number">(7)</span></a>
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<div class="ralinkpop offscreen_noflow">C1306710[trait identifier] AND "Centre for Mendelian Genomics, University Medical Centre Ljubljana"[submitter]<div class="brieflinkpopdesc">Search</div></div>
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<div class="tertiary">ClinVar</div>
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