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<meta name="keywords" content="C0153633, brain cancer, brain cancers, brain malignant neoplasm, brain malignant neoplasms, brain neoplasm, adult, brain neoplasm, malignant, brain neoplasms, malignant, brain tumor, adult, bt - brain tumor, bt - brain tumour, cancer of brain, cancer of the brain, cancer, brain, malignant brain neoplasm, malignant brain neoplasms, malignant brain tumor, malignant brain tumour, malignant neoplasm of brain, malignant neoplasm of the brain, malignant neoplasm, brain, malignant neoplasms, brain, malignant tumor of brain, malignant tumor of the brain, malignant tumour of brain, malignant tumour of the brain, neoplasm of unspecified nature of brain, neoplasms, brain, malignant, neoplastic process, primary brain neoplasm, primary brain tumor, primary brain tumour, primary malignant neoplasm of brain, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A primary or metastatic malignant neoplasm affecting the brain." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Malignant neoplasm of brain (Concept Id: C0153633)
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<!--
UID=57796
ConceptID=C0153633
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Malignant neoplasm of brain</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57796</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0153633</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Brain cancer; Malignant brain neoplasm</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Malignant neoplasm of brain (428061005)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0001657" target="_blank">MONDO:0001657</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A primary or metastatic malignant neoplasm affecting the brain. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="TLline"><a href="/medgen/14216" ref="tree=GTR&amp;ncbi_uid=14216&amp;link_uid=14216" title="View MedGen record for 'Neoplasm of brain'">Neoplasm of brain</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/99225" ref="tree=GTR&amp;ncbi_uid=99225&amp;link_uid=99225" title="View MedGen record for 'Benign neoplasm of brain'">Benign neoplasm of brain</a></span></li><li class="matched_ds"><span class="TLline">Malignant neoplasm of brain</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/14336" ref="tree=MeSH" title="MedGen record for Disorder of nervous system">Disorder of nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/3306" ref="tree=MeSH" title="MedGen record for Disorder of the central nervous system">Disorder of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/88335" ref="tree=MeSH" title="MedGen record for Neoplasm of the central nervous system">Neoplasm of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/287152" ref="tree=MeSH" title="MedGen record for Intracranial Neoplasm">Intracranial Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/235297" ref="tree=MeSH" title="MedGen record for Malignant Intracranial Neoplasm">Malignant Intracranial Neoplasm</a></span><ul><li><span class="matched_ds">Malignant neoplasm of brain</span><ul><li><span class="TLline"><a href="/medgen/277326" ref="tree=MeSH" title="MedGen record for Adult Malignant Brain Neoplasm">Adult Malignant Brain Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/231034" ref="tree=MeSH" title="MedGen record for Adult Brain Glioblastoma">Adult Brain Glioblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/277992" ref="tree=MeSH" title="MedGen record for Adult brainstem gliosarcoma">Adult brainstem gliosarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/235288" ref="tree=MeSH" title="MedGen record for Adult intracranial malignant hemangiopericytoma">Adult intracranial malignant hemangiopericytoma</a></span></li><li><span class="TLline"><a href="/medgen/78898" ref="tree=MeSH" title="MedGen record for Adult medulloblastoma">Adult medulloblastoma</a></span></li><li><span class="TLline"><a href="/medgen/83794" ref="tree=MeSH" title="MedGen record for Adult pineoblastoma">Adult pineoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/417054" ref="tree=MeSH" title="MedGen record for Adult Supratentorial Embryonal Tumor, Not Otherwise Specified">Adult Supratentorial Embryonal Tumor, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/233184" ref="tree=MeSH" title="MedGen record for Metastatic Adult Malignant Neoplasm in the Brain">Metastatic Adult Malignant Neoplasm in the Brain</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231457" ref="tree=MeSH" title="MedGen record for Brain germinoma">Brain germinoma</a></span><ul><li><span class="TLline"><a href="/medgen/272458" ref="tree=MeSH" title="MedGen record for Childhood brain germinoma">Childhood brain germinoma</a></span></li><li><span class="TLline"><a href="/medgen/208928" ref="tree=MeSH" title="MedGen record for Pineal region germinoma">Pineal region germinoma</a></span></li><li><span class="TLline"><a href="/medgen/1657133" ref="tree=MeSH" title="MedGen record for Third Ventricle Germinoma">Third Ventricle Germinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272381" ref="tree=MeSH" title="MedGen record for Brain sarcoma">Brain sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/138053" ref="tree=MeSH" title="MedGen record for Choroid plexus cancer">Choroid plexus cancer</a></span><ul><li><span class="TLline"><a href="/medgen/96557" ref="tree=MeSH" title="MedGen record for Choroid plexus carcinoma">Choroid plexus carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/901899" ref="tree=MeSH" title="MedGen record for Childhood choroid plexus carcinoma">Childhood choroid plexus carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1791983" ref="tree=MeSH" title="MedGen record for Recurrent Malignant Choroid Plexus Neoplasm">Recurrent Malignant Choroid Plexus Neoplasm</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87267" ref="tree=MeSH" title="MedGen record for Gliomatosis cerebri">Gliomatosis cerebri</a></span><ul><li><span class="TLline"><a href="/medgen/856664" ref="tree=MeSH" title="MedGen record for Childhood Gliomatosis Cerebri">Childhood 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href="/medgen/234121" ref="tree=MeSH" title="MedGen record for Childhood Brain Anaplastic Astrocytoma">Childhood Brain Anaplastic Astrocytoma</a></span><ul><li><span class="TLline"><a href="/medgen/859264" ref="tree=MeSH" title="MedGen record for Childhood Cerebral Anaplastic Astrocytoma">Childhood Cerebral Anaplastic Astrocytoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/927220" ref="tree=MeSH" title="MedGen record for Diffuse midline glioma, H3 K27M-mutant">Diffuse midline glioma, H3 K27M-mutant</a></span><ul><li><span class="TLline"><a href="/medgen/1791979" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Midline Glioma, H3 K27M-Mutant">Recurrent Diffuse Midline Glioma, H3 K27M-Mutant</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1650540" ref="tree=MeSH" title="MedGen record for Frontal Lobe Anaplastic Oligodendroglioma">Frontal Lobe Anaplastic Oligodendroglioma</a></span></li><li><span class="TLline"><a href="/medgen/231069" ref="tree=MeSH" title="MedGen record for Hemispheric Anaplastic Astrocytoma">Hemispheric Anaplastic Astrocytoma</a></span><ul><li><span class="TLline"><a href="/medgen/1660962" ref="tree=MeSH" title="MedGen record for Frontal Lobe Anaplastic Astrocytoma">Frontal Lobe Anaplastic Astrocytoma</a></span></li><li><span class="TLline"><a href="/medgen/1721747" ref="tree=MeSH" title="MedGen record for Parietal Lobe Anaplastic Astrocytoma">Parietal Lobe Anaplastic Astrocytoma</a></span></li><li><span class="TLline"><a href="/medgen/1659216" ref="tree=MeSH" title="MedGen record for Temporal Lobe Anaplastic Astrocytoma">Temporal Lobe Anaplastic Astrocytoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231374" ref="tree=MeSH" title="MedGen record for Secondary Supratentorial Anaplastic Astrocytoma">Secondary Supratentorial Anaplastic Astrocytoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/113095" ref="tree=MeSH" title="MedGen record for Metastatic malignant neoplasm in the brain">Metastatic malignant neoplasm in the brain</a></span><ul><li><span class="TLline"><a href="/medgen/234049" ref="tree=MeSH" title="MedGen record for Breast Carcinoma Metastatic in the Brain">Breast Carcinoma Metastatic in the Brain</a></span></li><li><span class="TLline"><a href="/medgen/235265" ref="tree=MeSH" title="MedGen record for Lung Carcinoma Metastatic in the Brain">Lung Carcinoma Metastatic in the Brain</a></span></li><li><span class="TLline"><a href="/medgen/1791970" ref="tree=MeSH" title="MedGen record for Melanoma Metastatic in the Brain">Melanoma Metastatic in the Brain</a></span></li><li><span class="TLline"><a href="/medgen/277637" ref="tree=MeSH" title="MedGen record for Secondary Cerebral Hodgkin Lymphoma">Secondary Cerebral Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1788110" ref="tree=MeSH" title="MedGen record for Metastatic Primary Malignant Brain Neoplasm">Metastatic Primary Malignant Brain Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1782849" ref="tree=MeSH" title="MedGen record for Advanced Primary Malignant Brain Neoplasm">Advanced Primary Malignant Brain Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1793122" ref="tree=MeSH" title="MedGen record for Locally Advanced Primary Malignant Brain Neoplasm">Locally Advanced Primary Malignant Brain Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1783727" ref="tree=MeSH" title="MedGen record for Metastatic Medulloblastoma">Metastatic Medulloblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/277356" ref="tree=MeSH" title="MedGen record for Medulloblastoma with Leptomeningeal Spread">Medulloblastoma with Leptomeningeal Spread</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1668960" ref="tree=MeSH" title="MedGen record for Recurrent Malignant Brain Neoplasm">Recurrent Malignant Brain Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/854380" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Pineoblastoma">Recurrent Childhood Pineoblastoma</a></span></li><li><span class="TLline"><a href="/medgen/852501" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified">Recurrent Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1624822" ref="tree=MeSH" title="MedGen record for Recurrent Diffuse Intrinsic Pontine Glioma">Recurrent Diffuse Intrinsic Pontine Glioma</a></span></li><li><span class="TLline"><a href="/medgen/235539" ref="tree=MeSH" title="MedGen record for Recurrent Medulloblastoma">Recurrent Medulloblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/137886" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Medulloblastoma">Recurrent Childhood Medulloblastoma</a></span></li><li><span class="TLline"><a href="/medgen/1633055" ref="tree=MeSH" title="MedGen record for Recurrent Medulloblastoma, SHH-Activated">Recurrent Medulloblastoma, SHH-Activated</a></span></li><li><span class="TLline"><a href="/medgen/1793138" ref="tree=MeSH" title="MedGen record for Recurrent Medulloblastoma, WNT-Activated">Recurrent Medulloblastoma, WNT-Activated</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1752130" ref="tree=MeSH" title="MedGen record for Recurrent Supratentorial Glioblastoma">Recurrent Supratentorial Glioblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667258" ref="tree=MeSH" title="MedGen record for Refractory Malignant Brain Neoplasm">Refractory Malignant Brain Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1627149" ref="tree=MeSH" title="MedGen record for Refractory Diffuse Intrinsic Pontine Glioma">Refractory Diffuse Intrinsic Pontine Glioma</a></span></li><li><span class="TLline"><a href="/medgen/1642493" ref="tree=MeSH" title="MedGen record for Refractory Medulloblastoma">Refractory Medulloblastoma</a></span><ul><li><span class="TLline"><a href="/medgen/1642267" ref="tree=MeSH" title="MedGen record for Refractory Medulloblastoma, SHH-Activated">Refractory Medulloblastoma, SHH-Activated</a></span></li><li><span class="TLline"><a href="/medgen/1793137" ref="tree=MeSH" title="MedGen record for Refractory Medulloblastoma, WNT-Activated">Refractory Medulloblastoma, WNT-Activated</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/155589" ref="tree=MeSH" title="MedGen record for Supratentorial cancer">Supratentorial cancer</a></span><ul><li><span class="TLline"><a href="/medgen/91109" ref="tree=MeSH" title="MedGen record for Cerebral hemisphere cancer">Cerebral hemisphere cancer</a></span><ul><li><span class="TLline"><a href="/medgen/1390376" ref="tree=MeSH" title="MedGen record for Central Nervous System Ganglioneuroblastoma">Central Nervous System Ganglioneuroblastoma</a></span></li><li><span class="TLline"><a href="/medgen/234110" ref="tree=MeSH" title="MedGen record for Cerebral Glioblastoma">Cerebral Glioblastoma</a></span></li><li><span class="TLline"><a href="/medgen/116109" ref="tree=MeSH" title="MedGen record for Cerebral lymphoma">Cerebral lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/107851" ref="tree=MeSH" title="MedGen record for Cerebral neuroblastoma">Cerebral neuroblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1375924" ref="tree=MeSH" title="MedGen record for Childhood supratentorial embryonal tumor with multilayered rosettes, C19MC-altered">Childhood supratentorial embryonal tumor with multilayered rosettes, C19MC-altered</a></span><ul><li><span class="TLline"><a href="/medgen/234125" ref="tree=MeSH" title="MedGen record for Pediatric cerebral ependymoblastoma">Pediatric cerebral ependymoblastoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233659" ref="tree=MeSH" title="MedGen record for Diencephalic cancer">Diencephalic cancer</a></span><ul><li><span class="TLline"><a href="/medgen/232424" ref="tree=MeSH" title="MedGen record for Diencephalic Glioblastoma">Diencephalic Glioblastoma</a></span></li><li><span class="TLline"><a href="/medgen/148264" ref="tree=MeSH" title="MedGen record for Malignant Hypothalamic Neoplasm">Malignant Hypothalamic Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/83429" ref="tree=MeSH" title="MedGen record for Thalamic cancer">Thalamic cancer</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/102284" ref="tree=MeSH" title="MedGen record for Pineal gland cancer">Pineal gland cancer</a></span><ul><li><span class="TLline"><a href="/medgen/233159" ref="tree=MeSH" title="MedGen record for Malignant pineal area germ cell neoplasm">Malignant pineal area germ cell neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/104745" ref="tree=MeSH" title="MedGen record for Pineoblastoma">Pineoblastoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/37459849">Glioblastoma Multiforme: The Latest Diagnostics and Treatment Techniques.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Czarnywojtek A,
Borowska M,
Dyrka K,
Van Gool S,
Sawicka-Gutaj N,
Moskal J,
Kościński J,
Graczyk P,
Hałas T,
Lewandowska AM,
Czepczyński R,
Ruchała M</span><br />
<span class="medgenPMjournal">Pharmacology</span>
2023;108(5):423-431.
Epub 2023 Jul 17
doi: 10.1159/000531319.
<span class="bold">PMID: </span><a href="/pubmed/37459849" target="_blank">37459849</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34261630">Glioblastoma: clinical presentation, diagnosis, and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McKinnon C,
Nandhabalan M,
Murray SA,
Plaha P</span><br />
<span class="medgenPMjournal">BMJ</span>
2021 Jul 14;374:n1560.
doi: 10.1136/bmj.n1560.
<span class="bold">PMID: </span><a href="/pubmed/34261630" target="_blank">34261630</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21296991">Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Melmed S,
Casanueva FF,
Hoffman AR,
Kleinberg DL,
Montori VM,
Schlechte JA,
Wass JA;
Endocrine Society</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2011 Feb;96(2):273-88.
doi: 10.1210/jc.2010-1692.
<span class="bold">PMID: </span><a href="/pubmed/21296991" target="_blank">21296991</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20neoplasm%20of%20brain)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (10591)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng99" target="_blank">UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/30797715">Global, regional, and national burden of brain and other CNS cancer, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2016 Brain and Other CNS Cancer Collaborators</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2019 Apr;18(4):376-393.
Epub 2019 Feb 21
doi: 10.1016/S1474-4422(18)30468-X.
<span class="bold">PMID: </span><a href="/pubmed/30797715" target="_blank">30797715</a><a href="/pmc/articles/PMC6416167" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29524371">Inequalities in Cancer Deaths by Age, Gender and Education.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gróf M,
Vagašová T,
Oltman M,
Skladaný Ľ,
Maličká L</span><br />
<span class="medgenPMjournal">Cent Eur J Public Health</span>
2017 Dec;25 Suppl 2:S59-S63.
doi: 10.21101/cejph.a5055.
<span class="bold">PMID: </span><a href="/pubmed/29524371" target="_blank">29524371</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20neoplasm%20of%20brain%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/30797715">Global, regional, and national burden of brain and other CNS cancer, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2016 Brain and Other CNS Cancer Collaborators</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2019 Apr;18(4):376-393.
Epub 2019 Feb 21
doi: 10.1016/S1474-4422(18)30468-X.
<span class="bold">PMID: </span><a href="/pubmed/30797715" target="_blank">30797715</a><a href="/pmc/articles/PMC6416167" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24882829">Harlequin syndrome as a complication of epidural anesthesia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Boling B,
Key C,
Wainscott J,
Rebel A</span><br />
<span class="medgenPMjournal">Crit Care Nurse</span>
2014 Jun;34(3):57-61.
doi: 10.4037/ccn2014870.
<span class="bold">PMID: </span><a href="/pubmed/24882829" target="_blank">24882829</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20neoplasm%20of%20brain%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/24882829">Harlequin syndrome as a complication of epidural anesthesia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Boling B,
Key C,
Wainscott J,
Rebel A</span><br />
<span class="medgenPMjournal">Crit Care Nurse</span>
2014 Jun;34(3):57-61.
doi: 10.4037/ccn2014870.
<span class="bold">PMID: </span><a href="/pubmed/24882829" target="_blank">24882829</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20neoplasm%20of%20brain%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/30797715">Global, regional, and national burden of brain and other CNS cancer, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2016 Brain and Other CNS Cancer Collaborators</span><br />
<span class="medgenPMjournal">Lancet Neurol</span>
2019 Apr;18(4):376-393.
Epub 2019 Feb 21
doi: 10.1016/S1474-4422(18)30468-X.
<span class="bold">PMID: </span><a href="/pubmed/30797715" target="_blank">30797715</a><a href="/pmc/articles/PMC6416167" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29524371">Inequalities in Cancer Deaths by Age, Gender and Education.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gróf M,
Vagašová T,
Oltman M,
Skladaný Ľ,
Maličká L</span><br />
<span class="medgenPMjournal">Cent Eur J Public Health</span>
2017 Dec;25 Suppl 2:S59-S63.
doi: 10.21101/cejph.a5055.
<span class="bold">PMID: </span><a href="/pubmed/29524371" target="_blank">29524371</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20neoplasm%20of%20brain%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Malignant%20neoplasm%20of%20brain" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20neoplasm%20of%20brain)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Malignant%20neoplasm%20of%20brain%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng99">NICE, 2021</a><div>UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021</div></li></ul></div>
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