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<meta name="keywords" content="C0036346, childhood onset schizophrenia, childhood schizophrenia, childhood-onset schizophrenia, cos - childhood-onset schizophrenia, mental or behavioral dysfunction, schizophrenia, childhood, schizophrenia, childhood-onset, veos - very early-onset schizophrenia, very early-onset schizophrenia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A rare neurologic disease with psychiatric involvement with characteristics of prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact." /><meta name="robots" content="index,nofollow,noarchive" />
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||
<!--
|
||
UID=48576
|
||
ConceptID=C0036346
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Childhood-onset schizophrenia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>48576</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0036346</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Childhood schizophrenia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Very early-onset schizophrenia (1335862003); VEOS - very early-onset schizophrenia (1335862003); Childhood-onset schizophrenia (1335862003); COS - childhood-onset schizophrenia (1335862003)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0957430" target="_blank">MONDO:0957430</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A rare neurologic disease with psychiatric involvement with characteristics of prominent pre-psychotic developmental disabilities (cognitive, language, motor), socio-communicative disturbances, auditory hallucinations (visual and tactile hallucinations are rarer) preceding psychotic symptoms, presenting before 13 years of age. Co-occurrence of neurodevelopmental disorders (e.g. autism spectrum disorders, attention deficit hyperactivity disorder) is frequent. Disease course is more severe than adult-onset form of the disease, with major neurodevelopmental impact. [from <a title="US Edition of SNOMED CT" href="http://www.nlm.nih.gov/research/umls/Snomed/us_edition.html" class="defSource" target="_blank">SNOMEDCT_US</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/1800824" ref="tree=GTR&ncbi_uid=1800824&link_uid=1800824" title="View MedGen record for 'Early-onset schizophrenia'">Early-onset schizophrenia</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0036346[DISCUI]&test_type=Clinical" ref="ncbi_uid=48576">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=48576" ref="ncbi_uid=48576">V</a></span></span><span class="TLline">Childhood-onset schizophrenia</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1842807" ref="tree=MeSH" title="MedGen record for Rare neurologic disease with psychiatric involvement">Rare neurologic disease with psychiatric involvement</a></span><ul><li><span class="TLline"><a href="/medgen/1800824" ref="tree=MeSH" title="MedGen record for Early-onset schizophrenia">Early-onset schizophrenia</a></span><ul><li><span class="matched_ds">Childhood-onset schizophrenia</span></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38492329">Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Correll CU,
|
||
Arango C,
|
||
Fagerlund B,
|
||
Galderisi S,
|
||
Kas MJ,
|
||
Leucht S</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2024 May;82:57-71.
|
||
Epub 2024 Mar 15
|
||
doi: 10.1016/j.euroneuro.2024.02.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38492329" target="_blank">38492329</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35099269">Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adnan M,
|
||
Motiwala F,
|
||
Trivedi C,
|
||
Sultana T,
|
||
Mansuri Z,
|
||
Jain S</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2022 Feb;32(1):2-11.
|
||
Epub 2022 Jan 28
|
||
doi: 10.1089/cap.2021.0092.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35099269" target="_blank">35099269</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28526280">An overview of medical risk factors for childhood psychosis: Implications for research and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giannitelli M,
|
||
Consoli A,
|
||
Raffin M,
|
||
Jardri R,
|
||
Levinson DF,
|
||
Cohen D,
|
||
Laurent-Levinson C</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2018 Feb;192:39-49.
|
||
Epub 2017 May 16
|
||
doi: 10.1016/j.schres.2017.05.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28526280" target="_blank">28526280</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22childhood-onset%20schizophrenia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (15)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38492329">Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Correll CU,
|
||
Arango C,
|
||
Fagerlund B,
|
||
Galderisi S,
|
||
Kas MJ,
|
||
Leucht S</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2024 May;82:57-71.
|
||
Epub 2024 Mar 15
|
||
doi: 10.1016/j.euroneuro.2024.02.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38492329" target="_blank">38492329</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31708054">Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Driver DI,
|
||
Thomas S,
|
||
Gogtay N,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Child Adolesc Psychiatr Clin N Am</span>
|
||
2020 Jan;29(1):71-90.
|
||
doi: 10.1016/j.chc.2019.08.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31708054" target="_blank">31708054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31708045">Genetics of Childhood-onset Schizophrenia 2019 Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Forsyth JK,
|
||
Asarnow RF</span><br />
|
||
<span class="medgenPMjournal">Child Adolesc Psychiatr Clin N Am</span>
|
||
2020 Jan;29(1):157-170.
|
||
Epub 2019 Oct 17
|
||
doi: 10.1016/j.chc.2019.08.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31708045" target="_blank">31708045</a><a href="/pmc/articles/PMC6954004" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22797279">Early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remschmidt H,
|
||
Theisen F</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
2012;66(1):63-9.
|
||
Epub 2012 Jul 13
|
||
doi: 10.1159/000338548.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22797279" target="_blank">22797279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20566189">Childhood-onset schizophrenia: insights from neuroimaging studies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gogtay N,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Child Adolesc Psychiatry</span>
|
||
2008 Oct;47(10):1120-4.
|
||
Epub 2009 Aug 21
|
||
doi: 10.1097/CHI.0b013e31817eed7a.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20566189" target="_blank">20566189</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (187)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38492329">Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Correll CU,
|
||
Arango C,
|
||
Fagerlund B,
|
||
Galderisi S,
|
||
Kas MJ,
|
||
Leucht S</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2024 May;82:57-71.
|
||
Epub 2024 Mar 15
|
||
doi: 10.1016/j.euroneuro.2024.02.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38492329" target="_blank">38492329</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32470234">Co-Occurrence of Autistic Spectrum Disorder and Childhood-Onset Schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hatila S,
|
||
Solanki G</span><br />
|
||
<span class="medgenPMjournal">Prim Care Companion CNS Disord</span>
|
||
2020 May 28;22(3)
|
||
doi: 10.4088/PCC.19l02515.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32470234" target="_blank">32470234</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31708054">Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Driver DI,
|
||
Thomas S,
|
||
Gogtay N,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Child Adolesc Psychiatr Clin N Am</span>
|
||
2020 Jan;29(1):71-90.
|
||
doi: 10.1016/j.chc.2019.08.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31708054" target="_blank">31708054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22797279">Early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remschmidt H,
|
||
Theisen F</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
2012;66(1):63-9.
|
||
Epub 2012 Jul 13
|
||
doi: 10.1159/000338548.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22797279" target="_blank">22797279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7868633">Annotation: childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Asarnow JR</span><br />
|
||
<span class="medgenPMjournal">J Child Psychol Psychiatry</span>
|
||
1994 Nov;35(8):1345-71.
|
||
doi: 10.1111/j.1469-7610.1994.tb01280.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7868633" target="_blank">7868633</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (174)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38492329">Identification and treatment of individuals with childhood-onset and early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Correll CU,
|
||
Arango C,
|
||
Fagerlund B,
|
||
Galderisi S,
|
||
Kas MJ,
|
||
Leucht S</span><br />
|
||
<span class="medgenPMjournal">Eur Neuropsychopharmacol</span>
|
||
2024 May;82:57-71.
|
||
Epub 2024 Mar 15
|
||
doi: 10.1016/j.euroneuro.2024.02.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38492329" target="_blank">38492329</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31708054">Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Driver DI,
|
||
Thomas S,
|
||
Gogtay N,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Child Adolesc Psychiatr Clin N Am</span>
|
||
2020 Jan;29(1):71-90.
|
||
doi: 10.1016/j.chc.2019.08.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31708054" target="_blank">31708054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22797279">Early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remschmidt H,
|
||
Theisen F</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
2012;66(1):63-9.
|
||
Epub 2012 Jul 13
|
||
doi: 10.1159/000338548.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22797279" target="_blank">22797279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17670793">Antipsychotic medication for childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kennedy E,
|
||
Kumar A,
|
||
Datta SS</span><br />
|
||
<span class="medgenPMjournal">Schizophr Bull</span>
|
||
2007 Sep;33(5):1082-3.
|
||
Epub 2007 Aug 1
|
||
doi: 10.1093/schbul/sbm080.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17670793" target="_blank">17670793</a><a href="/pmc/articles/PMC2632357" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1352624">Childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gordon CT</span><br />
|
||
<span class="medgenPMjournal">New Dir Ment Health Serv</span>
|
||
1992 Summer;(54):71-5.
|
||
doi: 10.1002/yd.23319925414.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1352624" target="_blank">1352624</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (70)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31708054">Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders: An Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Driver DI,
|
||
Thomas S,
|
||
Gogtay N,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Child Adolesc Psychiatr Clin N Am</span>
|
||
2020 Jan;29(1):71-90.
|
||
doi: 10.1016/j.chc.2019.08.017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31708054" target="_blank">31708054</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30513688">Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hoffmann A,
|
||
Ziller M,
|
||
Spengler D</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2018 Nov 30;19(12)
|
||
doi: 10.3390/ijms19123829.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30513688" target="_blank">30513688</a><a href="/pmc/articles/PMC6321410" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26234702">Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ordóñez AE,
|
||
Sastry NV,
|
||
Gogtay N</span><br />
|
||
<span class="medgenPMjournal">CNS Spectr</span>
|
||
2015 Aug;20(4):442-50.
|
||
doi: 10.1017/S1092852915000437.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26234702" target="_blank">26234702</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22797279">Early-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Remschmidt H,
|
||
Theisen F</span><br />
|
||
<span class="medgenPMjournal">Neuropsychobiology</span>
|
||
2012;66(1):63-9.
|
||
Epub 2012 Jul 13
|
||
doi: 10.1159/000338548.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22797279" target="_blank">22797279</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22032743">Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mattai A,
|
||
Miller R,
|
||
Weisinger B,
|
||
Greenstein D,
|
||
Bakalar J,
|
||
Tossell J,
|
||
David C,
|
||
Wassermann EM,
|
||
Rapoport J,
|
||
Gogtay N</span><br />
|
||
<span class="medgenPMjournal">Brain Stimul</span>
|
||
2011 Oct;4(4):275-80.
|
||
Epub 2011 Feb 1
|
||
doi: 10.1016/j.brs.2011.01.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22032743" target="_blank">22032743</a><a href="/pmc/articles/PMC3204188" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (74)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36645932">Genetic insights into childhood-onset schizophrenia: The yield of clinical exome sequencing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alkelai A,
|
||
Greenbaum L,
|
||
Shohat S,
|
||
Povysil G,
|
||
Malakar A,
|
||
Ren Z,
|
||
Motelow JE,
|
||
Schechter T,
|
||
Draiman B,
|
||
Chitrit-Raveh E,
|
||
Hughes D,
|
||
Jobanputra V,
|
||
Shifman S,
|
||
Goldstein DB,
|
||
Kohn Y</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2023 Feb;252:138-145.
|
||
Epub 2023 Jan 14
|
||
doi: 10.1016/j.schres.2022.12.033.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36645932" target="_blank">36645932</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35099269">Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adnan M,
|
||
Motiwala F,
|
||
Trivedi C,
|
||
Sultana T,
|
||
Mansuri Z,
|
||
Jain S</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2022 Feb;32(1):2-11.
|
||
Epub 2022 Jan 28
|
||
doi: 10.1089/cap.2021.0092.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35099269" target="_blank">35099269</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29146021">Symptom dimensions and subgroups in childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Craddock KES,
|
||
Zhou X,
|
||
Liu S,
|
||
Gochman P,
|
||
Dickinson D,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Schizophr Res</span>
|
||
2018 Jul;197:71-77.
|
||
Epub 2017 Nov 13
|
||
doi: 10.1016/j.schres.2017.10.045.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29146021" target="_blank">29146021</a><a href="/pmc/articles/PMC5949241" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25510512">Common polygenic variation and risk for childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahn K,
|
||
An SS,
|
||
Shugart YY,
|
||
Rapoport JL</span><br />
|
||
<span class="medgenPMjournal">Mol Psychiatry</span>
|
||
2016 Jan;21(1):94-6.
|
||
Epub 2014 Dec 16
|
||
doi: 10.1038/mp.2014.158.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25510512" target="_blank">25510512</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10933117">Treatment of childhood-onset schizophrenia with olanzapine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sholevar EH,
|
||
Baron DA,
|
||
Hardie TL</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2000 Summer;10(2):69-78.
|
||
doi: 10.1089/cap.2000.10.69.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10933117" target="_blank">10933117</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (101)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/39299241">Multiple complex developmental disorder (MCDD): Did we throw the baby out with the bathwater too fast? A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zaccaria V,
|
||
Ardizzone I,
|
||
Pisani F,
|
||
Raballo A,
|
||
Poletti M</span><br />
|
||
<span class="medgenPMjournal">Clin Child Psychol Psychiatry</span>
|
||
2025 Jan;30(1):5-19.
|
||
Epub 2024 Sep 19
|
||
doi: 10.1177/13591045241285486.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39299241" target="_blank">39299241</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35099269">Clozapine for Management of Childhood and Adolescent-Onset Schizophrenia: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Adnan M,
|
||
Motiwala F,
|
||
Trivedi C,
|
||
Sultana T,
|
||
Mansuri Z,
|
||
Jain S</span><br />
|
||
<span class="medgenPMjournal">J Child Adolesc Psychopharmacol</span>
|
||
2022 Feb;32(1):2-11.
|
||
Epub 2022 Jan 28
|
||
doi: 10.1089/cap.2021.0092.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35099269" target="_blank">35099269</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17636744">Antipsychotic medication for childhood-onset schizophrenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kennedy E,
|
||
Kumar A,
|
||
Datta SS</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2007 Jul 18;2007(3):CD004027.
|
||
doi: 10.1002/14651858.CD004027.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17636744" target="_blank">17636744</a><a href="/pmc/articles/PMC6984668" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Childhood-onset%20schizophrenia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
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|
||
<div class=" bottom">
|
||
|
||
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|
||
|
||
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|
||
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|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
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|
||
|
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<!-- MedGen supplemental column starts here -->
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<div class="rightCol mgCol">
|
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|
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0036346%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0036346%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0036346%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Childhood-onset%20schizophrenia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22childhood-onset%20schizophrenia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Childhood-onset%20schizophrenia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a href="/pubmed/clinical?term=Childhood-onset%20schizophrenia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Childhood-onset%20schizophrenia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d180b8a68b6b5afccc48f6">Childhood-onset schizophrenia</a>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d180b2b15b832ebc65748c">C3661900[trait identifier] AND "Shaikh Laboratory, University of ... <span class="number">(8)</span></a>
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