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<meta name="keywords" content="C0024591, anaesthesia related hyperthermia, anesthesia hyperthermia, anesthesia related hyperthermia, anesthesic-triggered malignant hyperthermia, hyperpyrexia, malignant, hyperthermia of anaesthesia, hyperthermia of anesthesia, hyperthermia, anesthesia related, hyperthermia, malignant, malignant hyperpyrexia, malignant hyperpyrexia caused by anesthesia, malignant hyperpyrexia caused by anesthetic, malignant hyperpyrexia due to anaesthesia, malignant hyperpyrexia due to anesthesia, malignant hyperpyrexias, malignant hyperthermia, malignant hyperthermia caused by anesthesia, malignant hyperthermia caused by anesthetic, malignant hyperthermia of anesthesia, malignant hyperthermia syndrome, malignant hyperthermia with anaesthesia, malignant hyperthermia with anesthesia, pathologic function, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Malignant hyperthermia susceptibility (MHS) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated with uncontrolled skeletal muscle hypermetabolism. Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine). The triggering substances cause uncontrolled release of calcium from the sarcoplasmic reticulum and may promote entry of extracellular calcium into the myoplasm, causing contracture of skeletal muscles, glycogenolysis, and increased cellular metabolism, resulting in production of heat and excess lactate. Affected individuals experience acidosis, hypercapnia, tachycardia, hyperthermia, muscle rigidity, compartment syndrome, rhabdomyolysis with subsequent increase in serum creatine kinase (CK) concentration, hyperkalemia with a risk for cardiac arrhythmia or even cardiac arrest, and myoglobinuria with a risk for renal failure. In nearly all cases, the first manifestations of MH (tachycardia and tachypnea) occur in the operating room; however, MH may also occur in the early postoperative period. There is mounting evidence that some individuals with MHS will also develop MH with exercise and/or on exposure to hot environments. Without proper and prompt treatment with dantrolene sodium, mortality is extremely high." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=9867
|
||
ConceptID=C0024591
|
||
-->
|
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<!--imgCountBooks = 2--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Images (2)</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1146/bin/mhs-Image002.gif" src-large="/books/NBK1146/bin/mhs-Image002.jpg" /></a><br /><a href="/books/NBK1146/figure/mhs.F2/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1146/bin/mhs-Image001.gif" src-large="/books/NBK1146/bin/mhs-Image001.jpg" /></a><br /><a href="/books/NBK1146/figure/mhs.F1/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Malignant hyperthermia of anesthesia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9867</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0024591</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Anesthesic-triggered malignant hyperthermia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Malignant hyperthermia caused by anesthesia (213026003); Malignant hyperpyrexia caused by anesthesia (213026003); Malignant hyperpyrexia caused by anesthetic (213026003); Malignant hyperthermia caused by anesthetic (213026003)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0034733">HP:0034733</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0018493" target="_blank">MONDO:0018493</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/145600" target="_blank">145600</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=423">ORPHA423</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1146" target="_blank">Malignant Hyperthermia Susceptibility</a></div><div>Malignant hyperthermia susceptibility (MHS) is a pharmacogenetic disorder of skeletal muscle calcium regulation associated with uncontrolled skeletal muscle hypermetabolism. Manifestations of malignant hyperthermia (MH) are precipitated by certain volatile anesthetics (i.e., halothane, isoflurane, sevoflurane, desflurane, enflurane), either alone or in conjunction with a depolarizing muscle relaxant (specifically, succinylcholine). The triggering substances cause uncontrolled release of calcium from the sarcoplasmic reticulum and may promote entry of extracellular calcium into the myoplasm, causing contracture of skeletal muscles, glycogenolysis, and increased cellular metabolism, resulting in production of heat and excess lactate. Affected individuals experience acidosis, hypercapnia, tachycardia, hyperthermia, muscle rigidity, compartment syndrome, rhabdomyolysis with subsequent increase in serum creatine kinase (CK) concentration, hyperkalemia with a risk for cardiac arrhythmia or even cardiac arrest, and myoglobinuria with a risk for renal failure. In nearly all cases, the first manifestations of MH (tachycardia and tachypnea) occur in the operating room; however, MH may also occur in the early postoperative period. There is mounting evidence that some individuals with MHS will also develop MH with exercise and/or on exposure to hot environments. Without proper and prompt treatment with dantrolene sodium, mortality is extremely high. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1146#mhs.Summary" target="NBK1146">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Diagnosis" target="NBK1146">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Clinical_Characteristics" target="NBK1146">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Genetically_Related_Allelic_Disorder" target="NBK1146">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Differential_Diagnosis" target="NBK1146">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Management" target="NBK1146">Management</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Genetic_Counseling" target="NBK1146">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Resources" target="NBK1146">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Molecular_Genetics" target="NBK1146">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.Chapter_Notes" target="NBK1146">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1146#mhs.References" target="NBK1146">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Henry Rosenberg | Nyamkhishig Sambuughin | Sheila Riazi<i>, et. al.</i> <a href="/books/NBK1146" target="NBK1146" title="NCBI Bookshelf: Malignant Hyperthermia Susceptibility">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From PharmGKB</strong><br />Malignant hyperthermia susceptibility (MHS) is a predisposition to a potentially life-threatening, hypermetabolic reaction triggered by potent volatile anesthetics (i.e. desflurane, enflurane, halothane, isoflurane, methoxyflurane, and sevoflurane) or the depolarizing muscle relaxant succinylcholine. These agents are relatively contraindicated in persons with MHS. MHS is diagnosed either by a positive response to the in vitro contracture test (IVCT) or the caffeine-halothane contracture test (CHCT), or by the presence of a pathogenic variant in RYR1 or CACNA1S that has been identified as causative for MHS (PMID: 30499100). Absence of pathogenetic variants in RYR1 or CACNA1S does not eliminate the chance of MHS based on findings that the genetic cause remains unknown for about half of all MH survivors, with contracture test-confirmed MHS (PMID: 28902675). Both genes are included on the list of actionable secondary findings by the American College of Medical Genetics and Genomics. MHS is inherited in an autosomal dominant manner and a positive result for a patient has familial ramifications. In addition to potential variations in RYR1 or CACNA1S, personal or family history of a reaction to these drugs or agents needs to be considered. Therapeutic guidelines for the use of potent volatile anesthetic agents and succinylcholine in the context of RYR1 or CACNA1S genotypes have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC). <a target="_blank" href="https://www.pharmgkb.org/guidelineAnnotation/PA166180457">https://www.pharmgkb.org/guidelineAnnotation/PA166180457</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/1813067" ref="tree=GTR&ncbi_uid=1813067&link_uid=1813067" title="View MedGen record for 'Rare disease with malignant hyperthermia'">Rare disease with malignant hyperthermia</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1850625[DISCUI]&test_type=Clinical" ref="ncbi_uid=340586">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=340586" target="_blank" href="/omim/255995">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK542808/" ref="ncbi_uid=340586">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=340586" ref="ncbi_uid=340586">V</a></span></span><span class="TLline"><a href="/medgen/340586" ref="tree=GTR&ncbi_uid=340586&link_uid=340586" title="View MedGen record for 'Bailey-Bloch congenital myopathy'">Bailey-Bloch congenital myopathy</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1840365[DISCUI]&test_type=Clinical" ref="ncbi_uid=327082">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=327082" target="_blank" href="/omim/180901">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=327082" ref="ncbi_uid=327082">V</a></span></span><span class="TLline"><a href="/medgen/327082" ref="tree=GTR&ncbi_uid=327082&link_uid=327082" title="View MedGen record for 'King Denborough syndrome'">King Denborough syndrome</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1830388" target="_blank" href="/omim/145600">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/1830388" ref="tree=GTR&ncbi_uid=1830388&link_uid=1830388" title="View MedGen record for 'Malignant hyperthermia'">Malignant hyperthermia</a></span><ul><li class="TLclosed"><span class="TLline"><a href="/medgen/1814609" ref="tree=GTR&ncbi_uid=1814609&link_uid=1814609" title="View MedGen record for 'Exercise-induced malignant hyperthermia'">Exercise-induced malignant hyperthermia</a></span><ul><li class="TLclosed"><span class="TLline"><a href="/medgen/808142" ref="tree=GTR&ncbi_uid=808142&link_uid=808142" title="View MedGen record for 'Malignant hyperthermia and exertional rhabdomyolosis'">Malignant hyperthermia and exertional rhabdomyolosis</a></span></li></ul></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0024591[DISCUI]&test_type=Clinical" ref="ncbi_uid=9867">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9867" target="_blank" href="/omim/145600">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=9867">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9867" ref="ncbi_uid=9867">V</a></span></span><span class="TLline">Malignant hyperthermia of anesthesia</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=1728755">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1728755" ref="ncbi_uid=1728755">V</a></span></span><span class="TLline"><a href="/medgen/1728755" ref="tree=GTR&ncbi_uid=1728755&link_uid=1728755" title="View MedGen record for 'Malignant hyperthermia, susceptibility to'">Malignant hyperthermia, susceptibility to</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2930980[DISCUI]&test_type=Clinical" ref="ncbi_uid=443948">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=443948" target="_blank" href="/omim/145600">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=443948">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=443948" ref="ncbi_uid=443948">V</a></span></span><span class="TLline"><a href="/medgen/443948" ref="tree=GTR&ncbi_uid=443948&link_uid=443948" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 1'">Malignant hyperthermia, susceptibility to, 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2930981[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=419301">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=419301" target="_blank" href="/omim/154275">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=419301">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/419301" ref="tree=GTR&ncbi_uid=419301&link_uid=419301" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 2'">Malignant hyperthermia, susceptibility to, 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2930982[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=418956">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=418956" target="_blank" href="/omim/154276">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=418956">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/418956" ref="tree=GTR&ncbi_uid=418956&link_uid=418956" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 3'">Malignant hyperthermia, susceptibility to, 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1838102[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=324944">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=324944" target="_blank" href="/omim/600467">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=324944">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/324944" ref="tree=GTR&ncbi_uid=324944&link_uid=324944" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 4'">Malignant hyperthermia, susceptibility to, 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1866077[DISCUI]&test_type=Clinical" ref="ncbi_uid=356151">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=356151" target="_blank" href="/omim/114208">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=356151">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=356151" ref="ncbi_uid=356151">V</a></span></span><span class="TLline"><a href="/medgen/356151" ref="tree=GTR&ncbi_uid=356151&link_uid=356151" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 5'">Malignant hyperthermia, susceptibility to, 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1866076[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=356150">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=356150" target="_blank" href="/omim/601888">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1146/" ref="ncbi_uid=356150">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/356150" ref="tree=GTR&ncbi_uid=356150&link_uid=356150" title="View MedGen record for 'Malignant hyperthermia, susceptibility to, 6'">Malignant hyperthermia, susceptibility to, 6</a></span></li></ul></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0270962[DISCUI]&test_type=Clinical" ref="ncbi_uid=75731">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0270962[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=75731">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=75731" ref="ncbi_uid=75731">V</a></span></span><span class="TLline"><a href="/medgen/75731" ref="tree=GTR&ncbi_uid=75731&link_uid=75731" title="View MedGen record for 'Multiminicore myopathy'">Multiminicore myopathy</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C5830701[DISCUI]&test_type=Clinical" ref="ncbi_uid=1841337">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1841337" target="_blank" href="/omim/117000">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=1841337" ref="ncbi_uid=1841337">V</a></span></span><span class="TLline"><a href="/medgen/1841337" ref="tree=GTR&ncbi_uid=1841337&link_uid=1841337" title="View MedGen record for 'Central core myopathy'">Central core myopathy</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1850674[DISCUI]&test_type=Clinical" ref="ncbi_uid=340597">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=340597" target="_blank" href="/omim/180901">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=340597" ref="ncbi_uid=340597">V</a></span></span><span class="TLline"><a href="/medgen/340597" ref="tree=GTR&ncbi_uid=340597&link_uid=340597" title="View MedGen record for 'Congenital multicore myopathy with external ophthalmoplegia'">Congenital multicore myopathy with external ophthalmoplegia</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=347490" target="_blank" href="/omim/217150">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/347490" ref="tree=GTR&ncbi_uid=347490&link_uid=347490" title="View MedGen record for 'Multiple pterygium-malignant hyperthermia syndrome'">Multiple pterygium-malignant hyperthermia syndrome</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/10320" ref="tree=GTR&ncbi_uid=10320&link_uid=10320" title="View MedGen record for 'Neuroleptic malignant syndrome'">Neuroleptic malignant syndrome</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/152119" ref="tree=GTR&ncbi_uid=152119&link_uid=152119" title="View MedGen record for 'Serotonin syndrome'">Serotonin syndrome</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/5870" ref="tree=MeSH" title="MedGen record for Intraoperative complication">Intraoperative complication</a></span><ul><li><span class="matched_ds">Malignant hyperthermia of anesthesia</span></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=649&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Malignant hyperthermia of anesthesia</span> in Orphanet.</div></div></div>
|
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</div>
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<div class="portlet mgSection" id="ID_105">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/35849058">Updated variant curation expert panel criteria and pathogenicity classifications for 251 variants for RYR1-related malignant hyperthermia susceptibility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johnston JJ,
|
||
Dirksen RT,
|
||
Girard T,
|
||
Hopkins PM,
|
||
Kraeva N,
|
||
Ognoon M,
|
||
Radenbaugh KB,
|
||
Riazi S,
|
||
Robinson RL,
|
||
Saddic Iii LA,
|
||
Sambuughin N,
|
||
Saxena R,
|
||
Shepherd S,
|
||
Stowell K,
|
||
Weber J,
|
||
Yoo S,
|
||
Rosenberg H,
|
||
Biesecker LG</span><br />
|
||
<span class="medgenPMjournal">Hum Mol Genet</span>
|
||
2022 Nov 28;31(23):4087-4093.
|
||
doi: 10.1093/hmg/ddac145.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35849058" target="_blank">35849058</a><a href="/pmc/articles/PMC9703808" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399225">Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins PM,
|
||
Girard T,
|
||
Dalay S,
|
||
Jenkins B,
|
||
Thacker A,
|
||
Patteril M,
|
||
McGrady E</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2021 May;76(5):655-664.
|
||
Epub 2021 Jan 5
|
||
doi: 10.1111/anae.15317.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399225" target="_blank">33399225</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33131754">Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rüffert H,
|
||
Bastian B,
|
||
Bendixen D,
|
||
Girard T,
|
||
Heiderich S,
|
||
Hellblom A,
|
||
Hopkins PM,
|
||
Johannsen S,
|
||
Snoeck MM,
|
||
Urwyler A,
|
||
Glahn KPE;
|
||
European Malignant Hyperthermia Group</span><br />
|
||
<span class="medgenPMjournal">Br J Anaesth</span>
|
||
2021 Jan;126(1):120-130.
|
||
Epub 2020 Oct 31
|
||
doi: 10.1016/j.bja.2020.09.029.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33131754" target="_blank">33131754</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20hyperthermia%20of%20anesthesia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (60)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.orpha.net/data/patho/Pro/en/Emergency_MalignantHyperthermia-enPro649.pdf" target="_blank">Orphanet Emergency Guidelines: Malignant hyperthermia</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/14870754">Malignant hyperthermia genetic testing in North America Working Group Meeting. Bethesda, Maryland. September 4-5, 2002.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sei Y,
|
||
Sambuughin N,
|
||
Muldoon S</span><br />
|
||
<span class="medgenPMjournal">Anesthesiology</span>
|
||
2004 Feb;100(2):464-5.
|
||
doi: 10.1097/00000542-200402000-00058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14870754" target="_blank">14870754</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33773826">European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lott C,
|
||
Truhlář A,
|
||
Alfonzo A,
|
||
Barelli A,
|
||
González-Salvado V,
|
||
Hinkelbein J,
|
||
Nolan JP,
|
||
Paal P,
|
||
Perkins GD,
|
||
Thies KC,
|
||
Yeung J,
|
||
Zideman DA,
|
||
Soar J;
|
||
ERC Special Circumstances Writing Group Collaborators</span><br />
|
||
<span class="medgenPMjournal">Resuscitation</span>
|
||
2021 Apr;161:152-219.
|
||
Epub 2021 Mar 24
|
||
doi: 10.1016/j.resuscitation.2021.02.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33773826" target="_blank">33773826</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399225">Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins PM,
|
||
Girard T,
|
||
Dalay S,
|
||
Jenkins B,
|
||
Thacker A,
|
||
Patteril M,
|
||
McGrady E</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2021 May;76(5):655-664.
|
||
Epub 2021 Jan 5
|
||
doi: 10.1111/anae.15317.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399225" target="_blank">33399225</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29313907">Adverse drug reactions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patton K,
|
||
Borshoff DC</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2018 Jan;73 Suppl 1:76-84.
|
||
doi: 10.1111/anae.14143.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29313907" target="_blank">29313907</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25960145">RYR1-related myopathies: a wide spectrum of phenotypes throughout life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Snoeck M,
|
||
van Engelen BG,
|
||
Küsters B,
|
||
Lammens M,
|
||
Meijer R,
|
||
Molenaar JP,
|
||
Raaphorst J,
|
||
Verschuuren-Bemelmans CC,
|
||
Straathof CS,
|
||
Sie LT,
|
||
de Coo IF,
|
||
van der Pol WL,
|
||
de Visser M,
|
||
Scheffer H,
|
||
Treves S,
|
||
Jungbluth H,
|
||
Voermans NC,
|
||
Kamsteeg EJ</span><br />
|
||
<span class="medgenPMjournal">Eur J Neurol</span>
|
||
2015 Jul;22(7):1094-112.
|
||
Epub 2015 May 11
|
||
doi: 10.1111/ene.12713.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25960145" target="_blank">25960145</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3932397">Malignant hyperthermia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosenberg H</span><br />
|
||
<span class="medgenPMjournal">Hosp Pract (Off Ed)</span>
|
||
1985 Mar 15;20(3):139, 144-5, 148 passim.
|
||
doi: 10.1080/21548331.1985.11703021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3932397" target="_blank">3932397</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (362)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39171998">Malignant Hyperthermia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pinyavat T,
|
||
Riazi S,
|
||
Deng J,
|
||
Slessarev M,
|
||
Cuthbertson BH,
|
||
Ibarra Moreno CA,
|
||
Jerath A</span><br />
|
||
<span class="medgenPMjournal">Crit Care Med</span>
|
||
2024 Dec 1;52(12):1934-1940.
|
||
Epub 2024 Aug 22
|
||
doi: 10.1097/CCM.0000000000006401.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39171998" target="_blank">39171998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399225">Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins PM,
|
||
Girard T,
|
||
Dalay S,
|
||
Jenkins B,
|
||
Thacker A,
|
||
Patteril M,
|
||
McGrady E</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2021 May;76(5):655-664.
|
||
Epub 2021 Jan 5
|
||
doi: 10.1111/anae.15317.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399225" target="_blank">33399225</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32008650">Malignant Hyperthermia Update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ellinas H,
|
||
Albrecht MA</span><br />
|
||
<span class="medgenPMjournal">Anesthesiol Clin</span>
|
||
2020 Mar;38(1):165-181.
|
||
doi: 10.1016/j.anclin.2019.10.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32008650" target="_blank">32008650</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26775126">Perioperative thermoregulation and heat balance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sessler DI</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jun 25;387(10038):2655-2664.
|
||
Epub 2016 Jan 8
|
||
doi: 10.1016/S0140-6736(15)00981-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26775126" target="_blank">26775126</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26238698">Malignant hyperthermia: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosenberg H,
|
||
Pollock N,
|
||
Schiemann A,
|
||
Bulger T,
|
||
Stowell K</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2015 Aug 4;10:93.
|
||
doi: 10.1186/s13023-015-0310-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26238698" target="_blank">26238698</a><a href="/pmc/articles/PMC4524368" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (527)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39171998">Malignant Hyperthermia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pinyavat T,
|
||
Riazi S,
|
||
Deng J,
|
||
Slessarev M,
|
||
Cuthbertson BH,
|
||
Ibarra Moreno CA,
|
||
Jerath A</span><br />
|
||
<span class="medgenPMjournal">Crit Care Med</span>
|
||
2024 Dec 1;52(12):1934-1940.
|
||
Epub 2024 Aug 22
|
||
doi: 10.1097/CCM.0000000000006401.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39171998" target="_blank">39171998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33399225">Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins PM,
|
||
Girard T,
|
||
Dalay S,
|
||
Jenkins B,
|
||
Thacker A,
|
||
Patteril M,
|
||
McGrady E</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2021 May;76(5):655-664.
|
||
Epub 2021 Jan 5
|
||
doi: 10.1111/anae.15317.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33399225" target="_blank">33399225</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31040503">Malignant Hyperthermia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaur H,
|
||
Katyal N,
|
||
Yelam A,
|
||
Kumar K,
|
||
Srivastava H,
|
||
Govindarajan R</span><br />
|
||
<span class="medgenPMjournal">Mo Med</span>
|
||
2019 Mar-Apr;116(2):154-159.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31040503" target="_blank">31040503</a><a href="/pmc/articles/PMC6461318" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26775126">Perioperative thermoregulation and heat balance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sessler DI</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2016 Jun 25;387(10038):2655-2664.
|
||
Epub 2016 Jan 8
|
||
doi: 10.1016/S0140-6736(15)00981-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26775126" target="_blank">26775126</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4075218">Malignant hyperthermia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Britt BA</span><br />
|
||
<span class="medgenPMjournal">Can Anaesth Soc J</span>
|
||
1985 Nov;32(6):666-78.
|
||
doi: 10.1007/BF03011418.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4075218" target="_blank">4075218</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (677)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32236737">Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kushnir A,
|
||
Todd JJ,
|
||
Witherspoon JW,
|
||
Yuan Q,
|
||
Reiken S,
|
||
Lin H,
|
||
Munce RH,
|
||
Wajsberg B,
|
||
Melville Z,
|
||
Clarke OB,
|
||
Wedderburn-Pugh K,
|
||
Wronska A,
|
||
Razaqyar MS,
|
||
Chrismer IC,
|
||
Shelton MO,
|
||
Mankodi A,
|
||
Grunseich C,
|
||
Tarnopolsky MA,
|
||
Tanji K,
|
||
Hirano M,
|
||
Riazi S,
|
||
Kraeva N,
|
||
Voermans NC,
|
||
Gruber A,
|
||
Allen C,
|
||
Meilleur KG,
|
||
Marks AR</span><br />
|
||
<span class="medgenPMjournal">Acta Neuropathol</span>
|
||
2020 Jun;139(6):1089-1104.
|
||
Epub 2020 Mar 31
|
||
doi: 10.1007/s00401-020-02150-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32236737" target="_blank">32236737</a><a href="/pmc/articles/PMC7788518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30905562">Patient Safety and Anesthesia Considerations for Office-Based Otolaryngology Procedures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmalbach CE</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2019 Jun;52(3):379-390.
|
||
Epub 2019 Mar 22
|
||
doi: 10.1016/j.otc.2019.02.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30905562" target="_blank">30905562</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29313907">Adverse drug reactions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patton K,
|
||
Borshoff DC</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2018 Jan;73 Suppl 1:76-84.
|
||
doi: 10.1111/anae.14143.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29313907" target="_blank">29313907</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/324354">Malignant hyperpyrexia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stephen CR</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
1977;28:153-7.
|
||
doi: 10.1146/annurev.me.28.020177.001101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/324354" target="_blank">324354</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/4581791">Malignant hyperpyrexia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Relton JE,
|
||
Britt BA,
|
||
Steward DJ</span><br />
|
||
<span class="medgenPMjournal">Br J Anaesth</span>
|
||
1973 Mar;45(3):269-75.
|
||
doi: 10.1093/bja/45.3.269.
|
||
<span class="bold">PMID: </span><a href="/pubmed/4581791" target="_blank">4581791</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (156)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32236737">Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kushnir A,
|
||
Todd JJ,
|
||
Witherspoon JW,
|
||
Yuan Q,
|
||
Reiken S,
|
||
Lin H,
|
||
Munce RH,
|
||
Wajsberg B,
|
||
Melville Z,
|
||
Clarke OB,
|
||
Wedderburn-Pugh K,
|
||
Wronska A,
|
||
Razaqyar MS,
|
||
Chrismer IC,
|
||
Shelton MO,
|
||
Mankodi A,
|
||
Grunseich C,
|
||
Tarnopolsky MA,
|
||
Tanji K,
|
||
Hirano M,
|
||
Riazi S,
|
||
Kraeva N,
|
||
Voermans NC,
|
||
Gruber A,
|
||
Allen C,
|
||
Meilleur KG,
|
||
Marks AR</span><br />
|
||
<span class="medgenPMjournal">Acta Neuropathol</span>
|
||
2020 Jun;139(6):1089-1104.
|
||
Epub 2020 Mar 31
|
||
doi: 10.1007/s00401-020-02150-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32236737" target="_blank">32236737</a><a href="/pmc/articles/PMC7788518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30905562">Patient Safety and Anesthesia Considerations for Office-Based Otolaryngology Procedures.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmalbach CE</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2019 Jun;52(3):379-390.
|
||
Epub 2019 Mar 22
|
||
doi: 10.1016/j.otc.2019.02.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30905562" target="_blank">30905562</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28526149">Pharmacogenomics in Anesthesia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saba R,
|
||
Kaye AD,
|
||
Urman RD</span><br />
|
||
<span class="medgenPMjournal">Anesthesiol Clin</span>
|
||
2017 Jun;35(2):285-294.
|
||
doi: 10.1016/j.anclin.2017.01.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28526149" target="_blank">28526149</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2265884">Anesthesia and mental illness.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sedgwick JV,
|
||
Lewis IH,
|
||
Linter SP</span><br />
|
||
<span class="medgenPMjournal">Int J Psychiatry Med</span>
|
||
1990;20(3):209-25.
|
||
doi: 10.2190/T8ED-VBLX-ARP3-APGD.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2265884" target="_blank">2265884</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/324354">Malignant hyperpyrexia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stephen CR</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
1977;28:153-7.
|
||
doi: 10.1146/annurev.me.28.020177.001101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/324354" target="_blank">324354</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (171)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/30550426">Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Larach MG,
|
||
Klumpner TT,
|
||
Brandom BW,
|
||
Vaughn MT,
|
||
Belani KG,
|
||
Herlich A,
|
||
Kim TW,
|
||
Limoncelli J,
|
||
Riazi S,
|
||
Sivak EL,
|
||
Capacchione J,
|
||
Mashman D,
|
||
Kheterpal S,
|
||
Kooij F,
|
||
Wilczak J,
|
||
Soto R,
|
||
Berris J,
|
||
Price Z,
|
||
Lins S,
|
||
Coles P,
|
||
Harris JM,
|
||
Cummings KC 3rd,
|
||
Berman MF,
|
||
Nanamori M,
|
||
Adelman BT,
|
||
Wedeven C,
|
||
LaGorio J,
|
||
McCormick PJ,
|
||
Tom S,
|
||
Aziz MF,
|
||
Coffman T,
|
||
Ellis TA 2nd,
|
||
Molina S,
|
||
Peterson W,
|
||
Mackey SC,
|
||
van Klei WA,
|
||
Ginde AA,
|
||
Biggs DA,
|
||
Neuman MD,
|
||
Craft RM,
|
||
Pace NL,
|
||
Paganelli WC,
|
||
Durieux ME,
|
||
Nair BJ,
|
||
Wanderer JP,
|
||
Miller SA,
|
||
Helsten DL,
|
||
Turnbull ZA,
|
||
Schonberger RB;
|
||
Multicenter Perioperative Outcomes Group</span><br />
|
||
<span class="medgenPMjournal">Anesthesiology</span>
|
||
2019 Jan;130(1):41-54.
|
||
doi: 10.1097/ALN.0000000000002490.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30550426" target="_blank">30550426</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28326467">Malignant hyperthermia susceptibility in patients with exertional rhabdomyolysis: a retrospective cohort study and updated systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kraeva N,
|
||
Sapa A,
|
||
Dowling JJ,
|
||
Riazi S</span><br />
|
||
<span class="medgenPMjournal">Can J Anaesth</span>
|
||
2017 Jul;64(7):736-743.
|
||
Epub 2017 Mar 21
|
||
doi: 10.1007/s12630-017-0865-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28326467" target="_blank">28326467</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22190505">Effect of general anesthesia in patients with cerebral palsy at the turn of the new millennium: a population-based study evaluating perioperative outcome and brief overview of anesthetic implications of this coexisting disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wass CT,
|
||
Warner ME,
|
||
Worrell GA,
|
||
Castagno JA,
|
||
Howe M,
|
||
Kerber KA,
|
||
Palzkill JM,
|
||
Schroeder DR,
|
||
Cascino GD</span><br />
|
||
<span class="medgenPMjournal">J Child Neurol</span>
|
||
2012 Jul;27(7):859-66.
|
||
Epub 2011 Dec 21
|
||
doi: 10.1177/0883073811428378.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22190505" target="_blank">22190505</a><a href="/pmc/articles/PMC3561730" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21376345">Cardiopulmonary bypass in malignant hyperthermia susceptible patients: a systematic review of published cases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Metterlein T,
|
||
Zink W,
|
||
Kranke E,
|
||
Haneya A,
|
||
Graf B,
|
||
Kranke P</span><br />
|
||
<span class="medgenPMjournal">J Thorac Cardiovasc Surg</span>
|
||
2011 Jun;141(6):1488-95.
|
||
Epub 2011 Mar 3
|
||
doi: 10.1016/j.jtcvs.2011.01.034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21376345" target="_blank">21376345</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malignant%20hyperthermia%20of%20anesthesia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
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|
||
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|
||
<div class=" bottom">
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||
|
||
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|
||
|
||
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|
||
</div>
|
||
<div class="supplemental col three_col last">
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0024591%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0024591%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (8)</a></li>
|
||
<li><a href="/gtr/tests?term=C0024591%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0024591%5bDISCUI%5d" target="_blank">See all (8)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=423" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Malignant%20hyperthermia%20of%20anesthesia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(malignant%20hyperthermia%20of%20anesthesia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Malignant%20hyperthermia%20of%20anesthesia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.orpha.net/data/patho/Pro/en/Emergency_MalignantHyperthermia-enPro649.pdf">Orphanet, 2013</a><div>Orphanet Emergency Guidelines: Malignant hyperthermia</div></li></ul></div>
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||
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/malignant_hyperthermia_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Malignant%20hyperthermia%20of%20anesthesia" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/6964/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
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|
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<div class="portlet_head">
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<h3>Reviews</h3>
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<li>
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<a href="/pubmed/20301325" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
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||
<li>
|
||
<a href="/pubmed/clinical?term=Malignant%20hyperthermia%20of%20anesthesia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
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<li>
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||
<a href="/pubmed?term=Malignant%20hyperthermia%20of%20anesthesia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
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||
<li class="brieflinkpopper">
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||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=9867" ref="log$=recordlinks">ClinVar</a>
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||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0024591[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0024591[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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