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<meta name="keywords" content="C0024314, disorder, lymphoproliferative, disorders, lymphoproliferative, lymphoproliferative disorder, lymphoproliferative disorders, lymphoproliferative syndrome, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=6162
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||
ConceptID=C0024314
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Lymphoproliferative disorder</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6162</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0024314</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Lymphoproliferative syndrome</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Lymphoproliferative disorder (414629003); Lymphoproliferative disorder (277466009)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0005523">HP:0005523</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0016537" target="_blank">MONDO:0016537</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span> Phenotypic series:</td>
|
||
<td><a href="https://omim.org/phenotypicSeries/PS308240" target="_blank">PS308240</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=238510">ORPHA238510</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0024314[DISCUI]&test_type=Clinical" ref="ncbi_uid=6162">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=6162" ref="ncbi_uid=6162">V</a></span></span><span class="TLline">Lymphoproliferative disorder</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span 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14</a></span></li><li><span class="TLline"><a href="/medgen/863371" ref="tree=MeSH" title="MedGen record for Immunodeficiency 36">Immunodeficiency 36</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1639972" ref="tree=MeSH" title="MedGen record for Isolated agammaglobulinemia">Isolated agammaglobulinemia</a></span><ul><li><span class="TLline"><a href="/medgen/316941" ref="tree=MeSH" title="MedGen record for Autosomal agammaglobulinemia">Autosomal agammaglobulinemia</a></span></li><li><span class="TLline"><a href="/medgen/65123" ref="tree=MeSH" title="MedGen record for X-linked agammaglobulinemia">X-linked agammaglobulinemia</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/75674" ref="tree=MeSH" title="MedGen record for AL amyloidosis">AL amyloidosis</a></span><ul><li><span class="TLline"><a href="/medgen/107462" ref="tree=MeSH" title="MedGen record for Primary localized amyloidosis">Primary localized amyloidosis</a></span></li><li><span 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href="/medgen/208921" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Ann Arbor Stage I Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li><li><span class="TLline"><a href="/medgen/167724" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Ann Arbor Stage II Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li><li><span class="TLline"><a href="/medgen/167725" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Ann Arbor Stage III Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li><li><span class="TLline"><a href="/medgen/163156" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Ann Arbor Stage IV Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/167723" ref="tree=MeSH" title="MedGen record for Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Recurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li><li><span class="TLline"><a href="/medgen/163154" ref="tree=MeSH" title="MedGen record for Refractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type">Refractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-Type</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75775" ref="tree=MeSH" title="MedGen record for Atypical lymphoproliferative disorder">Atypical lymphoproliferative disorder</a></span><ul><li><span class="TLline"><a href="/medgen/233998" ref="tree=MeSH" title="MedGen record for Atypical Gastric Lymphoid Hyperplasia">Atypical Gastric Lymphoid Hyperplasia</a></span></li><li><span class="TLline"><a href="/medgen/42211" ref="tree=MeSH" title="MedGen record for Castleman disease">Castleman disease</a></span><ul><li><span class="TLline"><a href="/medgen/231376" ref="tree=MeSH" title="MedGen record for Castleman Disease, Hyaline-Vascular Type">Castleman Disease, Hyaline-Vascular Type</a></span></li><li><span class="TLline"><a href="/medgen/231377" ref="tree=MeSH" title="MedGen record for Castleman Disease, Plasma Cell Type">Castleman Disease, Plasma Cell Type</a></span></li><li><span class="TLline"><a href="/medgen/1680858" ref="tree=MeSH" title="MedGen record for Idiopathic multicentric Castleman disease">Idiopathic multicentric Castleman disease</a></span></li><li><span class="TLline"><a href="/medgen/858176" ref="tree=MeSH" title="MedGen record for Localized Castleman disease">Localized Castleman disease</a></span></li><li><span class="TLline"><a href="/medgen/233197" ref="tree=MeSH" title="MedGen record for Multicentric Castleman disease">Multicentric Castleman disease</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1385652" ref="tree=MeSH" title="MedGen record for EBV positive mucocutaneous ulcer">EBV positive mucocutaneous ulcer</a></span></li><li><span class="TLline"><a href="/medgen/1383416" ref="tree=MeSH" title="MedGen record for Indolent T-Lymphoblastic Proliferation">Indolent T-Lymphoblastic Proliferation</a></span></li><li><span class="TLline"><a href="/medgen/1651750" ref="tree=MeSH" title="MedGen record for Severe Mosquito Bite Allergy">Severe Mosquito Bite Allergy</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/985772" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome">Autoimmune lymphoproliferative syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/231300" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome type 1">Autoimmune lymphoproliferative syndrome type 1</a></span><ul><li><span class="TLline"><a href="/medgen/356454" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome type 1, autosomal recessive">Autoimmune lymphoproliferative syndrome type 1, autosomal recessive</a></span></li><li><span class="TLline"><a href="/medgen/356453" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome, type 1a">Autoimmune lymphoproliferative syndrome, type 1a</a></span></li><li><span class="TLline"><a href="/medgen/356158" ref="tree=MeSH" title="MedGen record for AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB">AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB</a></span></li><li><span class="TLline"><a href="/medgen/274327" ref="tree=MeSH" title="MedGen record for Type 3 autoimmune lymphoproliferative syndrome">Type 3 autoimmune lymphoproliferative syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/382434" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome type 4">Autoimmune lymphoproliferative syndrome type 4</a></span></li><li><span class="TLline"><a href="/medgen/349065" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome type 2A">Autoimmune lymphoproliferative syndrome type 2A</a></span></li><li><span class="TLline"><a href="/medgen/339548" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome type 2B">Autoimmune lymphoproliferative syndrome type 2B</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/863651" ref="tree=MeSH" title="MedGen record for Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency">Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency</a></span></li><li><span class="TLline"><a href="/medgen/1661274" ref="tree=MeSH" title="MedGen record for Autosomal recessive lymphoproliferative disease">Autosomal recessive lymphoproliferative disease</a></span></li><li><span class="TLline"><a href="/medgen/1791871" ref="tree=MeSH" title="MedGen record for B-Cell Lymphoproliferative Disorder">B-Cell Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/86953" ref="tree=MeSH" title="MedGen record for B-cell lymphoma">B-cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1635894" ref="tree=MeSH" title="MedGen record for Advanced B-Cell Malignant Neoplasm">Advanced B-Cell Malignant Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1791561" ref="tree=MeSH" title="MedGen record for Aggressive B-cell non-Hodgkin lymphoma">Aggressive B-cell non-Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/43099" ref="tree=MeSH" title="MedGen record for AIDS-Related Lymphoma">AIDS-Related Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163575" ref="tree=MeSH" title="MedGen record for B Lymphoblastic Leukemia/Lymphoma">B Lymphoblastic Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1632437" ref="tree=MeSH" title="MedGen record for B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage">B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/2377" ref="tree=MeSH" title="MedGen record for Burkitt lymphoma">Burkitt lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1632151" ref="tree=MeSH" title="MedGen record for Central Nervous System B-Cell Non-Hodgkin Lymphoma">Central Nervous System B-Cell Non-Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/7417" ref="tree=MeSH" title="MedGen record for Follicular lymphoma">Follicular lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/6161" ref="tree=MeSH" title="MedGen record for Lymphomatoid granulomatosis">Lymphomatoid granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/86954" ref="tree=MeSH" title="MedGen record for Malignant lymphoma, large B-cell, diffuse">Malignant lymphoma, large B-cell, diffuse</a></span></li><li><span class="TLline"><a href="/medgen/277345" ref="tree=MeSH" title="MedGen record for Mature B-Cell Non-Hodgkin Lymphoma">Mature B-Cell Non-Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/66942" ref="tree=MeSH" title="MedGen record for Mucosa-associated lymphoma">Mucosa-associated lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/235305" ref="tree=MeSH" title="MedGen record for Neoplasm of mature B-cells">Neoplasm of mature B-cells</a></span></li><li><span class="TLline"><a href="/medgen/220953" ref="tree=MeSH" title="MedGen record for Primary effusion lymphoma">Primary effusion lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167764" ref="tree=MeSH" title="MedGen record for Recurrent B-Cell Non-Hodgkin Lymphoma">Recurrent B-Cell Non-Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/208951" ref="tree=MeSH" title="MedGen record for Refractory B-Cell Non-Hodgkin Lymphoma">Refractory B-Cell Non-Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/474153" ref="tree=MeSH" title="MedGen record for Small Intestinal B-Cell Non-Hodgkin Lymphoma">Small Intestinal B-Cell Non-Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234269" ref="tree=MeSH" title="MedGen record for Follicular Bronchitis/Bronchiolitis">Follicular Bronchitis/Bronchiolitis</a></span></li><li><span class="TLline"><a href="/medgen/233758" ref="tree=MeSH" title="MedGen record for Nodular lymphocyte predominant Hodgkin lymphoma">Nodular lymphocyte predominant Hodgkin lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/231044" ref="tree=MeSH" title="MedGen record for Adult nodular lymphocyte predominant Hodgkin lymphoma">Adult nodular lymphocyte predominant Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/232351" ref="tree=MeSH" title="MedGen record for Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma">Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1632067" ref="tree=MeSH" title="MedGen record for Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage">Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/277583" ref="tree=MeSH" title="MedGen record for Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma">Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233914" ref="tree=MeSH" title="MedGen record for Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma">Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277429" ref="tree=MeSH" title="MedGen record for Non-Destructive Post-Transplant Lymphoproliferative Disorder">Non-Destructive Post-Transplant Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1623644" ref="tree=MeSH" title="MedGen record for Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder">Florid Follicular Hyperplasia Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/233551" ref="tree=MeSH" title="MedGen record for Infectious Mononucleosis Post-Transplant Lymphoproliferative Disorder">Infectious Mononucleosis Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/235482" ref="tree=MeSH" title="MedGen record for Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder">Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/196657" ref="tree=MeSH" title="MedGen record for Benign Lymphoproliferative Disorder">Benign Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/268922" ref="tree=MeSH" title="MedGen record for Chronic lymphoproliferative disorder of NK-cells">Chronic lymphoproliferative disorder of NK-cells</a></span></li><li><span class="TLline"><a href="/medgen/7069" ref="tree=MeSH" title="MedGen record for Infectious mononucleosis">Infectious mononucleosis</a></span></li><li><span class="TLline"><a href="/medgen/7410" ref="tree=MeSH" title="MedGen record for Lymphadenitis">Lymphadenitis</a></span><ul><li><span class="TLline"><a href="/medgen/56380" ref="tree=MeSH" title="MedGen record for Acute lymphadenitis">Acute lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/182522" ref="tree=MeSH" title="MedGen record for Axillary lymphadenitis">Axillary lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/2861" ref="tree=MeSH" title="MedGen record for Cat scratch disease">Cat scratch disease</a></span></li><li><span class="TLline"><a href="/medgen/101763" ref="tree=MeSH" title="MedGen record for cervical lymphadenitis">cervical lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/57588" ref="tree=MeSH" title="MedGen record for Chronic lymphadenitis">Chronic lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/97979" ref="tree=MeSH" title="MedGen record for Kikuchi-Fujimoto disease">Kikuchi-Fujimoto disease</a></span></li><li><span class="TLline"><a href="/medgen/46183" ref="tree=MeSH" title="MedGen record for Kimura disease">Kimura disease</a></span></li><li><span class="TLline"><a href="/medgen/6318" ref="tree=MeSH" title="MedGen record for Mesenteric lymphadenitis">Mesenteric lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/183076" ref="tree=MeSH" title="MedGen record for Postauricular lymphadenitis">Postauricular lymphadenitis</a></span></li><li><span class="TLline"><a href="/medgen/66723" ref="tree=MeSH" title="MedGen record for Submandibular adenitis">Submandibular adenitis</a></span></li><li><span class="TLline"><a href="/medgen/140258" ref="tree=MeSH" title="MedGen record for Suppurative lymphadenitis">Suppurative lymphadenitis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/81385" ref="tree=MeSH" title="MedGen record for Lymphocytoma cutis">Lymphocytoma cutis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272514" ref="tree=MeSH" title="MedGen record for Cutaneous Lymphoproliferative Disorder">Cutaneous Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/699354" ref="tree=MeSH" title="MedGen record for Cutaneous Lymphoma">Cutaneous Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/313067" ref="tree=MeSH" title="MedGen record for Cutaneous Adult T-Cell Leukemia/Lymphoma">Cutaneous Adult T-Cell Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1719114" ref="tree=MeSH" title="MedGen record for Cutaneous Burkitt Lymphoma">Cutaneous Burkitt Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/272512" ref="tree=MeSH" title="MedGen record for Cutaneous Follicular Lymphoma">Cutaneous Follicular Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/313070" ref="tree=MeSH" title="MedGen record for Cutaneous Mantle Cell Lymphoma">Cutaneous Mantle Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/313081" ref="tree=MeSH" title="MedGen record for Cutaneous Nasal Type Extranodal NK/T-Cell Lymphoma">Cutaneous Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/220981" ref="tree=MeSH" title="MedGen record for Primary cutaneous lymphoma">Primary cutaneous lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317555" ref="tree=MeSH" title="MedGen record for Cutaneous Mature B-Cell Neoplasm">Cutaneous Mature B-Cell Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/310644" ref="tree=MeSH" title="MedGen record for Cutaneous Chronic Lymphocytic Leukemia">Cutaneous Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/317554" ref="tree=MeSH" title="MedGen record for Cutaneous Lymphomatoid Granulomatosis">Cutaneous Lymphomatoid Granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/267969" ref="tree=MeSH" title="MedGen record for Primary Cutaneous B-Cell Non-Hodgkin Lymphoma">Primary Cutaneous B-Cell Non-Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/317556" ref="tree=MeSH" title="MedGen record for Cutaneous Mature T-Cell and NK-Cell Neoplasm">Cutaneous Mature T-Cell and NK-Cell Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/61534" ref="tree=MeSH" title="MedGen record for Lymphomatoid papulosis">Lymphomatoid papulosis</a></span></li><li><span class="TLline"><a href="/medgen/237165" ref="tree=MeSH" title="MedGen record for Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder">Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/1627444" ref="tree=MeSH" title="MedGen record for Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder">Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/36336" ref="tree=MeSH" title="MedGen record for Primary cutaneous T-cell lymphoma">Primary cutaneous T-cell lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/353585" ref="tree=MeSH" title="MedGen record for Cutaneous Precursor Lymphoid Neoplasm">Cutaneous Precursor Lymphoid Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/231366" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia Cutis">Aleukemic Acute Lymphoblastic Leukemia Cutis</a></span></li><li><span class="TLline"><a href="/medgen/313082" ref="tree=MeSH" title="MedGen record for Cutaneous B Lymphoblastic Leukemia/Lymphoma">Cutaneous B Lymphoblastic Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/310654" ref="tree=MeSH" title="MedGen record for Cutaneous T Lymphoblastic Leukemia/Lymphoma">Cutaneous T Lymphoblastic Leukemia/Lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/418980" ref="tree=MeSH" title="MedGen record for Dianzani autoimmune lymphoproliferative disease">Dianzani autoimmune lymphoproliferative disease</a></span></li><li><span class="TLline"><a href="/medgen/1842754" ref="tree=MeSH" title="MedGen record for Early-onset autoimmunity-autoinflammation-immunodeficiency syndrome">Early-onset autoimmunity-autoinflammation-immunodeficiency syndrome</a></span></li><li><span class="TLline"><a href="/medgen/797800" ref="tree=MeSH" title="MedGen record for Epstein-Barr virus-associated malignant lymphoproliferative disorder">Epstein-Barr virus-associated malignant lymphoproliferative disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1374328" ref="tree=MeSH" title="MedGen record for Diffuse large B-cell lymphoma with chronic inflammation">Diffuse large B-cell lymphoma with chronic inflammation</a></span></li><li><span class="TLline"><a href="/medgen/397515" ref="tree=MeSH" title="MedGen record for EBV-positive T-cell lymphoproliferative disorder of childhood">EBV-positive T-cell lymphoproliferative disorder of childhood</a></span><ul><li><span class="TLline"><a href="/medgen/317758" ref="tree=MeSH" title="MedGen record for Hydroa vacciniforme-like lymphoma">Hydroa vacciniforme-like lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/397492" ref="tree=MeSH" title="MedGen record for Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood">Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272582" ref="tree=MeSH" title="MedGen record for EBV-Related Lymphoma">EBV-Related Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/234224" ref="tree=MeSH" title="MedGen record for EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder">EBV-Related Clonal Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/234225" ref="tree=MeSH" title="MedGen record for EBV-Related Hodgkin Lymphoma">EBV-Related Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/272583" ref="tree=MeSH" title="MedGen record for EBV-Related Non-Hodgkin Lymphoma">EBV-Related Non-Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1644293" ref="tree=MeSH" title="MedGen record for Recurrent EBV-Related Lymphoma">Recurrent EBV-Related Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1700005" ref="tree=MeSH" title="MedGen record for Refractory EBV-Related Lymphoma">Refractory EBV-Related Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/397690" ref="tree=MeSH" title="MedGen record for Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly">Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly</a></span><ul><li><span class="TLline"><a href="/medgen/1670225" ref="tree=MeSH" title="MedGen record for Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Recurrent EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1669009" ref="tree=MeSH" title="MedGen record for Refractory EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">Refractory EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/140278" ref="tree=MeSH" title="MedGen record for Extranodal nasal NK/T cell lymphoma">Extranodal nasal NK/T cell lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/853495" ref="tree=MeSH" title="MedGen record for Adult Nasal Type Extranodal NK/T-Cell Lymphoma">Adult Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/361825" ref="tree=MeSH" title="MedGen record for Childhood Nasal Type Extranodal NK/T-Cell Lymphoma">Childhood Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1647216" ref="tree=MeSH" title="MedGen record for Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage">Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/163128" ref="tree=MeSH" title="MedGen record for Recurrent Nasal Type Extranodal NK/T-Cell Lymphoma">Recurrent Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163470" ref="tree=MeSH" title="MedGen record for Refractory Nasal Type Extranodal NK/T-Cell Lymphoma">Refractory Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1749027" ref="tree=MeSH" title="MedGen record for Sinonasal Extranodal NK/T-Cell Lymphoma">Sinonasal Extranodal NK/T-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1688783" ref="tree=MeSH" title="MedGen record for Testicular Nasal Type Extranodal NK/T-Cell Lymphoma">Testicular Nasal Type Extranodal NK/T-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1656332" ref="tree=MeSH" title="MedGen record for HHV8-Positive Germinotropic Lymphoproliferative Disorder">HHV8-Positive Germinotropic Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/483338" ref="tree=MeSH" title="MedGen record for Plasmablastic lymphoma">Plasmablastic lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/233110" ref="tree=MeSH" title="MedGen record for AIDS-Related Plasmablastic Lymphoma">AIDS-Related Plasmablastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233861" ref="tree=MeSH" title="MedGen record for Plasmablastic Lymphoma of Mucosa Site">Plasmablastic Lymphoma of Mucosa Site</a></span></li><li><span class="TLline"><a href="/medgen/354078" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Plasmablastic Lymphoma">Primary Cutaneous Plasmablastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1681920" ref="tree=MeSH" title="MedGen record for Recurrent Plasmablastic Lymphoma">Recurrent Plasmablastic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1675391" ref="tree=MeSH" title="MedGen record for Refractory Plasmablastic Lymphoma">Refractory Plasmablastic Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/98160" ref="tree=MeSH" title="MedGen record for Post-transplant lymphoproliferative disease">Post-transplant lymphoproliferative disease</a></span><ul><li><span class="TLline"><a href="/medgen/235365" ref="tree=MeSH" title="MedGen record for Neoplastic Post-Transplant Lymphoproliferative Disorder">Neoplastic Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79187" ref="tree=MeSH" title="MedGen record for Primary central nervous system lymphoma">Primary central nervous system lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/79263" ref="tree=MeSH" title="MedGen record for AIDS-related primary central nervous system lymphoma">AIDS-related primary central nervous system lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/853574" ref="tree=MeSH" title="MedGen record for Central Nervous System Hodgkin Lymphoma">Central Nervous System Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/745669" ref="tree=MeSH" title="MedGen record for Central nervous system non-hodgkin lymphoma">Central nervous system non-hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/116109" ref="tree=MeSH" title="MedGen record for Cerebral lymphoma">Cerebral lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/453225" ref="tree=MeSH" title="MedGen record for Meningeal Lymphoma">Meningeal Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1616585" ref="tree=MeSH" title="MedGen record for Recurrent Central Nervous System Lymphoma">Recurrent Central Nervous System Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1626037" ref="tree=MeSH" title="MedGen record for Refractory Central Nervous System Lymphoma">Refractory Central Nervous System Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/236836" ref="tree=MeSH" title="MedGen record for Spinal cord lymphoma">Spinal cord lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1842618" ref="tree=MeSH" title="MedGen record for Familial hyperinflammatory lymphoproliferative immunodeficiency">Familial hyperinflammatory lymphoproliferative immunodeficiency</a></span></li><li><span class="TLline"><a href="/medgen/5376" ref="tree=MeSH" title="MedGen record for Granuloma">Granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/1053878" ref="tree=MeSH" title="MedGen record for Breast granuloma">Breast granuloma</a></span></li><li><span class="TLline"><a href="/medgen/137683" ref="tree=MeSH" title="MedGen record for Cholesterol granuloma">Cholesterol granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/56364" ref="tree=MeSH" title="MedGen record for Middle ear cholesterol granuloma">Middle ear cholesterol granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/101797" ref="tree=MeSH" title="MedGen record for Cutaneous granuloma">Cutaneous granuloma</a></span></li><li><span class="TLline"><a href="/medgen/4979" ref="tree=MeSH" title="MedGen record for Eosinophilic granuloma">Eosinophilic granuloma</a></span></li><li><span class="TLline"><a href="/medgen/3088" ref="tree=MeSH" title="MedGen record for Eosinophilic granulomatosis with polyangiitis">Eosinophilic granulomatosis with polyangiitis</a></span></li><li><span class="TLline"><a href="/medgen/6672" ref="tree=MeSH" title="MedGen record for Foreign body granuloma">Foreign body granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/109406" ref="tree=MeSH" title="MedGen record for Dental granuloma">Dental granuloma</a></span></li><li><span class="TLline"><a href="/medgen/5258" ref="tree=MeSH" title="MedGen record for Foreign body granuloma of muscle">Foreign body granuloma of muscle</a></span></li><li><span class="TLline"><a href="/medgen/167705" ref="tree=MeSH" title="MedGen record for Silicon Granuloma">Silicon Granuloma</a></span></li><li><span class="TLline"><a href="/medgen/252946" ref="tree=MeSH" title="MedGen record for Talc Granuloma">Talc Granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6673" ref="tree=MeSH" title="MedGen record for Giant cell granuloma">Giant cell granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/41844" ref="tree=MeSH" title="MedGen record for Giant cell epulis">Giant cell epulis</a></span></li><li><span class="TLline"><a href="/medgen/102385" ref="tree=MeSH" title="MedGen record for Giant cell reparative granuloma">Giant cell reparative granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/88319" ref="tree=MeSH" title="MedGen record for Granuloma annulare">Granuloma annulare</a></span><ul><li><span class="TLline"><a href="/medgen/163540" ref="tree=MeSH" title="MedGen record for Aggravated Granuloma Annulare">Aggravated Granuloma Annulare</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232257" ref="tree=MeSH" title="MedGen record for Granuloma by Site">Granuloma by Site</a></span><ul><li><span class="TLline"><a href="/medgen/167702" ref="tree=MeSH" title="MedGen record for Bladder Granuloma">Bladder Granuloma</a></span></li><li><span class="TLline"><a href="/medgen/204257" ref="tree=MeSH" title="MedGen record for Cardiac Granuloma">Cardiac Granuloma</a></span></li><li><span class="TLline"><a href="/medgen/57830" ref="tree=MeSH" title="MedGen record for Granuloma of conjunctiva">Granuloma of conjunctiva</a></span></li><li><span class="TLline"><a href="/medgen/155428" ref="tree=MeSH" title="MedGen record for Hepatic granuloma">Hepatic granuloma</a></span></li><li><span class="TLline"><a href="/medgen/6674" ref="tree=MeSH" title="MedGen record for Laryngeal granuloma">Laryngeal granuloma</a></span></li><li><span class="TLline"><a href="/medgen/42292" ref="tree=MeSH" title="MedGen record for Nasal cavity and paranasal sinus lethal midline granuloma">Nasal cavity and paranasal sinus lethal midline granuloma</a></span></li><li><span class="TLline"><a href="/medgen/102330" ref="tree=MeSH" title="MedGen record for Orbital granuloma">Orbital granuloma</a></span></li><li><span class="TLline"><a href="/medgen/65908" ref="tree=MeSH" title="MedGen record for Pulmonary Granuloma">Pulmonary Granuloma</a></span></li><li><span class="TLline"><a href="/medgen/508429" ref="tree=MeSH" title="MedGen record for Umbilical granuloma">Umbilical granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6675" ref="tree=MeSH" title="MedGen record for Granuloma, Respiratory Tract">Granuloma, Respiratory Tract</a></span></li><li><span class="TLline"><a href="/medgen/109001" ref="tree=MeSH" title="MedGen record for Infective granuloma">Infective granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/163565" ref="tree=MeSH" title="MedGen record for Actinomycotic Granuloma">Actinomycotic Granuloma</a></span></li><li><span class="TLline"><a href="/medgen/234774" ref="tree=MeSH" title="MedGen record for Schistosome Granuloma">Schistosome Granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/316438" ref="tree=MeSH" title="MedGen record for Lipogranulomatosis">Lipogranulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/266158" ref="tree=MeSH" title="MedGen record for Necrobiotic xanthogranuloma">Necrobiotic xanthogranuloma</a></span></li><li><span class="TLline"><a href="/medgen/507852" ref="tree=MeSH" title="MedGen record for Necrotizing granulomatous inflammation">Necrotizing granulomatous inflammation</a></span></li><li><span class="TLline"><a href="/medgen/569107" ref="tree=MeSH" title="MedGen record for Non-necrotizing granuloma">Non-necrotizing granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/277632" ref="tree=MeSH" title="MedGen record for Sarcoidal Granuloma">Sarcoidal Granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/42293" ref="tree=MeSH" title="MedGen record for Plasma cell granuloma">Plasma cell granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/232665" ref="tree=MeSH" title="MedGen record for Intracranial Plasma Cell Granuloma">Intracranial Plasma Cell Granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/39085" ref="tree=MeSH" title="MedGen record for Pyogenic granuloma">Pyogenic granuloma</a></span><ul><li><span class="TLline"><a href="/medgen/11050" ref="tree=MeSH" title="MedGen record for Lobular Capillary Hemangioma of Skin and Subcutaneous Tissue">Lobular Capillary Hemangioma of Skin and Subcutaneous Tissue</a></span></li><li><span class="TLline"><a href="/medgen/277386" ref="tree=MeSH" title="MedGen record for Multiple Lobular Capillary Hemangiomas">Multiple Lobular Capillary Hemangiomas</a></span></li><li><span class="TLline"><a href="/medgen/78621" ref="tree=MeSH" title="MedGen record for Pyogenic granuloma of oral mucosa">Pyogenic granuloma of oral mucosa</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/297" ref="tree=MeSH" title="MedGen record for Skin epithelioid hemangioma">Skin epithelioid hemangioma</a></span><ul><li><span class="TLline"><a href="/medgen/1695660" ref="tree=MeSH" title="MedGen record for Penile Epithelioid Hemangioma">Penile Epithelioid Hemangioma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/87167" ref="tree=MeSH" title="MedGen record for Spermatogenic granuloma">Spermatogenic granuloma</a></span></li><li><span class="TLline"><a href="/medgen/854516" ref="tree=MeSH" title="MedGen record for Suppurative Granuloma">Suppurative Granuloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9727" ref="tree=MeSH" title="MedGen record for Hairy cell leukemia">Hairy cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/83554" ref="tree=MeSH" title="MedGen record for Progressive Hairy Cell Leukemia Initial Treatment">Progressive Hairy Cell Leukemia Initial Treatment</a></span></li><li><span class="TLline"><a href="/medgen/124657" ref="tree=MeSH" title="MedGen record for Recurrent Hairy Cell Leukemia">Recurrent Hairy Cell Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1639342" ref="tree=MeSH" title="MedGen record for Refractory hairy cell leukemia">Refractory hairy cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234812" ref="tree=MeSH" title="MedGen record for Splenic manifestation of hairy cell leukemia">Splenic manifestation of hairy cell leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/5469" ref="tree=MeSH" title="MedGen record for Heavy chain disease">Heavy chain disease</a></span><ul><li><span class="TLline"><a href="/medgen/42374" ref="tree=MeSH" title="MedGen record for Gamma heavy chain disease (clinical)">Gamma heavy chain disease (clinical)</a></span></li><li><span class="TLline"><a href="/medgen/66875" ref="tree=MeSH" title="MedGen record for Mu-heavy chain disease">Mu-heavy chain disease</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1664303" ref="tree=MeSH" title="MedGen record for HHV8-Related Lymphoproliferative Disorder">HHV8-Related Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/758641" ref="tree=MeSH" title="MedGen record for Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease">Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease</a></span><ul><li><span class="TLline"><a href="/medgen/233109" ref="tree=MeSH" title="MedGen record for AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease">AIDS-Related Diffuse Large B-Cell Lymphoma Arising in HHV8-Positive Multicentric Castleman Disease</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1615300" ref="tree=MeSH" title="MedGen record for HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified">HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1683931" ref="tree=MeSH" title="MedGen record for HHV8-Positive Multicentric Castleman Disease">HHV8-Positive Multicentric Castleman Disease</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44216" ref="tree=MeSH" title="MedGen record for Lymphangiomyoma">Lymphangiomyoma</a></span><ul><li><span class="TLline"><a href="/medgen/148366" ref="tree=MeSH" title="MedGen record for Lymphangiomyomatosis">Lymphangiomyomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/91161" ref="tree=MeSH" title="MedGen record for Lung lymphangioleiomyomatosis">Lung lymphangioleiomyomatosis</a></span></li><li><span class="TLline"><a href="/medgen/90948" ref="tree=MeSH" title="MedGen record for Skin Lymphangioleiomyomatosis">Skin Lymphangioleiomyomatosis</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/9728" ref="tree=MeSH" title="MedGen record for Lymphoid leukemia">Lymphoid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/7318" ref="tree=MeSH" title="MedGen record for Acute biphenotypic leukemia">Acute biphenotypic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/926425" ref="tree=MeSH" title="MedGen record for Infant Acute Biphenotypic Leukemia">Infant Acute Biphenotypic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1641256" ref="tree=MeSH" title="MedGen record for Recurrent Acute Biphenotypic Leukemia">Recurrent Acute Biphenotypic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1731320" ref="tree=MeSH" title="MedGen record for Refractory Acute Biphenotypic Leukemia">Refractory Acute Biphenotypic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7317" ref="tree=MeSH" title="MedGen record for Acute lymphoid leukemia">Acute lymphoid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/890737" ref="tree=MeSH" title="MedGen record for Acute Lymphoblastic Leukemia by Gene Expression Profile">Acute Lymphoblastic Leukemia by Gene Expression Profile</a></span></li><li><span class="TLline"><a href="/medgen/199693" ref="tree=MeSH" title="MedGen record for Adult acute lymphoblastic leukemia">Adult acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/231365" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia">Aleukemic Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/226949" ref="tree=MeSH" title="MedGen record for B-cell acute lymphoblastic leukemia">B-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44122" ref="tree=MeSH" title="MedGen record for Childhood acute lymphoblastic leukemia">Childhood acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/313581" ref="tree=MeSH" title="MedGen record for Ph-positive acute lymphoblastic leukemia">Ph-positive acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/83896" ref="tree=MeSH" title="MedGen record for Precursor B-cell acute lymphoblastic leukemia">Precursor B-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/976286" ref="tree=MeSH" title="MedGen record for Precursor T-cell acute lymphoblastic leukemia">Precursor T-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1632670" ref="tree=MeSH" title="MedGen record for Recurrent Acute Lymphoblastic Leukemia">Recurrent Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1612918" ref="tree=MeSH" title="MedGen record for Refractory Acute Lymphoblastic Leukemia">Refractory Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/368378" ref="tree=MeSH" title="MedGen record for T-cell acute lymphoblastic leukemia">T-cell acute lymphoblastic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/266235" ref="tree=MeSH" title="MedGen record for Aggressive NK-cell leukemia">Aggressive NK-cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1680914" ref="tree=MeSH" title="MedGen record for Recurrent Aggressive NK-Cell Leukemia">Recurrent Aggressive NK-Cell Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1676365" ref="tree=MeSH" title="MedGen record for Refractory Aggressive NK-Cell Leukemia">Refractory Aggressive NK-Cell Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83179" ref="tree=MeSH" title="MedGen record for Aleukemic Lymphoid Leukemia">Aleukemic Lymphoid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/482968" ref="tree=MeSH" title="MedGen record for Aleukemic Chronic Lymphocytic Leukemia">Aleukemic Chronic Lymphocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44120" ref="tree=MeSH" title="MedGen record for B-cell chronic lymphocytic leukemia">B-cell chronic lymphocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/232077" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation">Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation</a></span></li><li><span class="TLline"><a href="/medgen/272481" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation">Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/234147" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene">Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene</a></span></li><li><span class="TLline"><a href="/medgen/1647247" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia- Binet Staging System">Chronic Lymphocytic Leukemia- Binet Staging System</a></span></li><li><span class="TLline"><a href="/medgen/1647279" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia- Modified Rai Staging System">Chronic Lymphocytic Leukemia- Modified Rai Staging System</a></span></li><li><span class="TLline"><a href="/medgen/167714" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Lymphocytic Leukemia">Recurrent Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/124512" ref="tree=MeSH" title="MedGen record for Refractory Chronic Lymphocytic Leukemia">Refractory Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234810" ref="tree=MeSH" title="MedGen record for Splenic Manifestation of Chronic Lymphocytic Leukemia">Splenic Manifestation of Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1678720" ref="tree=MeSH" title="MedGen record for Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma">Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/412152" ref="tree=MeSH" title="MedGen record for B-Cell Leukemia">B-Cell Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/105396" ref="tree=MeSH" title="MedGen record for B-cell prolymphocytic leukemia">B-cell prolymphocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1658558" ref="tree=MeSH" title="MedGen record for Burkitt Leukemia">Burkitt Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/75998" ref="tree=MeSH" title="MedGen record for Adult Burkitt Leukemia">Adult Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/83525" ref="tree=MeSH" title="MedGen record for Childhood Burkitt Leukemia">Childhood Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1670551" ref="tree=MeSH" title="MedGen record for Recurrent Burkitt Leukemia">Recurrent Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1650262" ref="tree=MeSH" title="MedGen record for Refractory Burkitt Leukemia">Refractory Burkitt Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/91160" ref="tree=MeSH" title="MedGen record for Hairy cell leukemia variant">Hairy cell leukemia variant</a></span><ul><li><span class="TLline"><a href="/medgen/1746235" ref="tree=MeSH" title="MedGen record for Recurrent Hairy Cell Leukemia Variant">Recurrent Hairy Cell Leukemia Variant</a></span></li><li><span class="TLline"><a href="/medgen/1761125" ref="tree=MeSH" title="MedGen record for Refractory Hairy Cell Leukemia Variant">Refractory Hairy Cell Leukemia Variant</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163423" ref="tree=MeSH" title="MedGen record for Leukemic Phase of Lymphoma">Leukemic Phase of Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/231024" ref="tree=MeSH" title="MedGen record for Acute Adult T-Cell Leukemia/Lymphoma">Acute Adult T-Cell Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/272480" ref="tree=MeSH" title="MedGen record for Chronic Adult T-Cell Leukemia/Lymphoma">Chronic Adult T-Cell Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1613227" ref="tree=MeSH" title="MedGen record for Leukemic Nonnodal Mantle Cell Lymphoma">Leukemic Nonnodal Mantle Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/19959" ref="tree=MeSH" title="MedGen record for Sezary syndrome">Sezary syndrome</a></span></li><li><span class="TLline"><a href="/medgen/234795" ref="tree=MeSH" title="MedGen record for Smoldering Adult T-Cell Leukemia/Lymphoma">Smoldering Adult T-Cell Leukemia/Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9733" ref="tree=MeSH" title="MedGen record for Plasma cell leukemia">Plasma cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/409528" ref="tree=MeSH" title="MedGen record for Precursor Cell Lymphoblastic Leukemia-Lymphoma">Precursor Cell Lymphoblastic Leukemia-Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/44126" ref="tree=MeSH" title="MedGen record for Pre-B Acute Lymphoblastic Leukemia">Pre-B Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6062" ref="tree=MeSH" title="MedGen record for Prolymphocytic leukemia">Prolymphocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/277663" ref="tree=MeSH" title="MedGen record for Splenic manifestation of prolymphocytic leukemia">Splenic manifestation of prolymphocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/391707" ref="tree=MeSH" title="MedGen record for T-cell prolymphocytic leukemia">T-cell prolymphocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/870727" ref="tree=MeSH" title="MedGen record for T cell chronic lymphocytic lymphoma/leukemia">T cell chronic lymphocytic lymphoma/leukemia</a></span></li><li><span class="TLline"><a href="/medgen/363038" ref="tree=MeSH" title="MedGen record for T-cell large granular lymphocyte leukemia">T-cell large granular lymphocyte leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1793212" ref="tree=MeSH" title="MedGen record for Recurrent T-Cell Large Granular Lymphocyte Leukemia">Recurrent T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1794066" ref="tree=MeSH" title="MedGen record for Refractory T-Cell Large Granular Lymphocyte Leukemia">Refractory T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/236842" ref="tree=MeSH" title="MedGen record for Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia">Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/272804" ref="tree=MeSH" title="MedGen record for T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta">T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta</a></span></li><li><span class="TLline"><a href="/medgen/271549" ref="tree=MeSH" title="MedGen record for T-Cell Large Granular Lymphocyte Leukemia, Common Variant">T-Cell Large Granular Lymphocyte Leukemia, Common Variant</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6064" ref="tree=MeSH" title="MedGen record for T-cell leukemia">T-cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/279467" ref="tree=MeSH" title="MedGen record for Large granular lymphocyte leukemia">Large granular lymphocyte leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44128" ref="tree=MeSH" title="MedGen record for Leukemia-Lymphoma, Adult T-Cell">Leukemia-Lymphoma, Adult T-Cell</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/108626" ref="tree=MeSH" title="MedGen record for Lymphoid neoplasm">Lymphoid neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/44223" ref="tree=MeSH" title="MedGen record for Lymphoma">Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/233965" ref="tree=MeSH" title="MedGen record for Adult lymphoma">Adult lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1655589" ref="tree=MeSH" title="MedGen record for Advanced Lymphoma">Advanced Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234323" ref="tree=MeSH" title="MedGen record for B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma">B-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/9283" ref="tree=MeSH" title="MedGen record for Classic Hodgkin lymphoma">Classic Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/107468" ref="tree=MeSH" title="MedGen record for Composite lymphoma">Composite lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/79344" ref="tree=MeSH" title="MedGen record for Intraocular lymphoma">Intraocular lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/148175" ref="tree=MeSH" title="MedGen record for Localized Lymphoma">Localized Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1778179" ref="tree=MeSH" title="MedGen record for Locally Advanced Lymphoma">Locally Advanced Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233633" ref="tree=MeSH" title="MedGen record for Lymphoma by Site">Lymphoma by Site</a></span></li><li><span class="TLline"><a href="/medgen/1654240" ref="tree=MeSH" title="MedGen record for Methotrexate-Associated Lymphoma">Methotrexate-Associated Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/6160" ref="tree=MeSH" title="MedGen record for Non-Hodgkin lymphoma">Non-Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/232062" ref="tree=MeSH" title="MedGen record for Pediatric lymphoma">Pediatric lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1612938" ref="tree=MeSH" title="MedGen record for Recurrent Lymphoma">Recurrent Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1614250" ref="tree=MeSH" title="MedGen record for Refractory Lymphoma">Refractory Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1680878" ref="tree=MeSH" title="MedGen record for Unresectable Lymphoma">Unresectable Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234479" ref="tree=MeSH" title="MedGen record for Virus-Related Lymphoma">Virus-Related Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/235492" ref="tree=MeSH" title="MedGen record for Precursor lymphoblastic lymphoma/leukemia">Precursor lymphoblastic lymphoma/leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/42541" ref="tree=MeSH" title="MedGen record for Lymphoblastic lymphoma">Lymphoblastic lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/443133" ref="tree=MeSH" title="MedGen record for Natural Killer Cell Lymphoblastic Leukemia/Lymphoma">Natural Killer Cell Lymphoblastic Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/224897" ref="tree=MeSH" title="MedGen record for Precursor T-lymphoblastic lymphoma/leukemia">Precursor T-lymphoblastic lymphoma/leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1778039" ref="tree=MeSH" title="MedGen record for Recurrent Malignant Lymphoid Neoplasm">Recurrent Malignant Lymphoid Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1674441" ref="tree=MeSH" title="MedGen record for Recurrent B-Cell Prolymphocytic Leukemia">Recurrent B-Cell Prolymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1378471" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma">Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1766934" ref="tree=MeSH" title="MedGen record for Recurrent Mature T-Cell and NK-Cell Neoplasm">Recurrent Mature T-Cell and NK-Cell Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1682394" ref="tree=MeSH" title="MedGen record for Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder">Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/1753779" ref="tree=MeSH" title="MedGen record for Recurrent Plasma Cell Neoplasm">Recurrent Plasma Cell Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/167727" ref="tree=MeSH" title="MedGen record for Recurrent T Lymphoblastic Leukemia/Lymphoma">Recurrent T Lymphoblastic Leukemia/Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1767996" ref="tree=MeSH" title="MedGen record for Refractory Malignant Lymphoid Neoplasm">Refractory Malignant Lymphoid Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/1676333" ref="tree=MeSH" title="MedGen record for Refractory B-Cell Prolymphocytic Leukemia">Refractory B-Cell Prolymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1735371" ref="tree=MeSH" title="MedGen record for Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma">Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1777946" ref="tree=MeSH" title="MedGen record for Refractory Mature T-Cell and NK-Cell Neoplasm">Refractory Mature T-Cell and NK-Cell Neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/1683202" ref="tree=MeSH" title="MedGen record for Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder">Refractory Monomorphic Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/75844" ref="tree=MeSH" title="MedGen record for Refractory plasma cell neoplasm">Refractory plasma cell neoplasm</a></span></li><li><span class="TLline"><a href="/medgen/167728" ref="tree=MeSH" title="MedGen record for Refractory precursor T-lymphoblastic lymphoma/leukemia">Refractory precursor T-lymphoblastic lymphoma/leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/277781" ref="tree=MeSH" title="MedGen record for T-cell and NK-cell neoplasm">T-cell and NK-cell neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/233675" ref="tree=MeSH" title="MedGen record for Neoplasm of mature T-cells or NK-cells">Neoplasm of mature T-cells or NK-cells</a></span></li><li><span class="TLline"><a href="/medgen/86957" ref="tree=MeSH" title="MedGen record for T-cell lymphoma">T-cell lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/765548" ref="tree=MeSH" title="MedGen record for Lymphoproliferative syndrome 1">Lymphoproliferative syndrome 1</a></span></li><li><span class="TLline"><a href="/medgen/242753" ref="tree=MeSH" title="MedGen record for Macrophage activation syndrome">Macrophage activation syndrome</a></span></li><li><span class="TLline"><a href="/medgen/6219" ref="tree=MeSH" title="MedGen record for Marek Disease">Marek Disease</a></span></li><li><span class="TLline"><a href="/medgen/10122" ref="tree=MeSH" title="MedGen record for Multiple myeloma">Multiple myeloma</a></span><ul><li><span class="TLline"><a href="/medgen/1622876" ref="tree=MeSH" title="MedGen record for Multiple Myeloma by ISS Stage">Multiple Myeloma by ISS Stage</a></span><ul><li><span class="TLline"><a href="/medgen/378401" ref="tree=MeSH" title="MedGen record for ISS Stage I Multiple Myeloma">ISS Stage I Multiple Myeloma</a></span></li><li><span class="TLline"><a href="/medgen/378400" ref="tree=MeSH" title="MedGen record for ISS Stage II Multiple Myeloma">ISS Stage II Multiple Myeloma</a></span></li><li><span class="TLline"><a href="/medgen/384538" ref="tree=MeSH" title="MedGen record for ISS Stage III Multiple Myeloma">ISS Stage III Multiple Myeloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1638206" ref="tree=MeSH" title="MedGen record for Multiple Myeloma by RISS Stage">Multiple Myeloma by RISS Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1647477" ref="tree=MeSH" title="MedGen record for RISS Stage I Multiple Myeloma">RISS Stage I Multiple Myeloma</a></span></li><li><span class="TLline"><a href="/medgen/1632954" ref="tree=MeSH" title="MedGen record for RISS Stage II Multiple Myeloma">RISS Stage II Multiple Myeloma</a></span></li><li><span class="TLline"><a href="/medgen/1641034" ref="tree=MeSH" title="MedGen record for RISS Stage III Multiple Myeloma">RISS Stage III Multiple Myeloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233860" ref="tree=MeSH" title="MedGen record for Multiple Myeloma Post-Transplant Lymphoproliferative Disorder">Multiple Myeloma Post-Transplant Lymphoproliferative Disorder</a></span></li><li><span class="TLline"><a href="/medgen/857719" ref="tree=MeSH" title="MedGen record for Non-secretory plasma cell myeloma">Non-secretory plasma cell myeloma</a></span></li><li><span class="TLline"><a href="/medgen/857662" ref="tree=MeSH" title="MedGen record for Osteosclerotic plasma cell myeloma">Osteosclerotic plasma cell myeloma</a></span></li><li><span class="TLline"><a href="/medgen/237158" ref="tree=MeSH" title="MedGen record for Recurrent Multiple Myeloma">Recurrent Multiple Myeloma</a></span></li><li><span class="TLline"><a href="/medgen/1636255" ref="tree=MeSH" title="MedGen record for Refractory Multiple Myeloma">Refractory Multiple Myeloma</a></span><ul><li><span class="TLline"><a href="/medgen/1791432" ref="tree=MeSH" title="MedGen record for Triple-Class Refractory Multiple Myeloma">Triple-Class Refractory Multiple Myeloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/280653" ref="tree=MeSH" title="MedGen record for Smoldering plasma cell myeloma">Smoldering plasma cell myeloma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/18506" ref="tree=MeSH" title="MedGen record for Plasmacytoma">Plasmacytoma</a></span><ul><li><span class="TLline"><a href="/medgen/419825" ref="tree=MeSH" title="MedGen record for Anaplastic Plasmacytoma">Anaplastic Plasmacytoma</a></span></li><li><span class="TLline"><a href="/medgen/75843" ref="tree=MeSH" title="MedGen record for Extramedullary plasmacytoma">Extramedullary plasmacytoma</a></span><ul><li><span class="TLline"><a href="/medgen/1737342" ref="tree=MeSH" title="MedGen record for Sinonasal Plasmacytoma">Sinonasal Plasmacytoma</a></span></li><li><span class="TLline"><a href="/medgen/1689279" ref="tree=MeSH" title="MedGen record for Testicular Plasmacytoma">Testicular Plasmacytoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1842608" ref="tree=MeSH" title="MedGen record for Extramedullary soft tissue plasmacytoma">Extramedullary soft tissue plasmacytoma</a></span></li><li><span class="TLline"><a href="/medgen/832012" ref="tree=MeSH" title="MedGen record for Primary plasmacytoma of the bone">Primary plasmacytoma of the bone</a></span></li><li><span class="TLline"><a href="/medgen/75777" ref="tree=MeSH" title="MedGen record for Solitary osseous plasmacytoma">Solitary osseous plasmacytoma</a></span></li><li><span class="TLline"><a href="/medgen/232340" ref="tree=MeSH" title="MedGen record for Solitary plasmacytoma of chest wall">Solitary plasmacytoma of chest wall</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1639766" ref="tree=MeSH" title="MedGen record for Recurrent Lymphoproliferative Disorder">Recurrent Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/75923" ref="tree=MeSH" title="MedGen record for Recurrent Lymphomatoid Granulomatosis">Recurrent Lymphomatoid Granulomatosis</a></span><ul><li><span class="TLline"><a href="/medgen/883610" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Lymphomatoid Granulomatosis">Recurrent Childhood Lymphomatoid Granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/853347" ref="tree=MeSH" title="MedGen record for Recurrent Grade I Lymphomatoid Granulomatosis">Recurrent Grade I Lymphomatoid Granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/853348" ref="tree=MeSH" title="MedGen record for Recurrent Grade II Lymphomatoid Granulomatosis">Recurrent Grade II Lymphomatoid Granulomatosis</a></span></li><li><span class="TLline"><a href="/medgen/378769" ref="tree=MeSH" title="MedGen record for Recurrent Grade III Lymphomatoid Granulomatosis">Recurrent Grade III Lymphomatoid Granulomatosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1672883" ref="tree=MeSH" title="MedGen record for Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder">Recurrent Polymorphic Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1675052" ref="tree=MeSH" title="MedGen record for Refractory Lymphoproliferative Disorder">Refractory Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1682220" ref="tree=MeSH" title="MedGen record for Refractory Polymorphic Post-Transplant Lymphoproliferative Disorder">Refractory Polymorphic Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/48554" ref="tree=MeSH" title="MedGen record for Sarcoidosis">Sarcoidosis</a></span><ul><li><span class="TLline"><a href="/medgen/140260" ref="tree=MeSH" title="MedGen record for Cardiac sarcoidosis">Cardiac sarcoidosis</a></span></li><li><span class="TLline"><a href="/medgen/140767" ref="tree=MeSH" title="MedGen record for Cerebral sarcoidosis">Cerebral sarcoidosis</a></span></li><li><span class="TLline"><a href="/medgen/272729" ref="tree=MeSH" title="MedGen record for Hypercalcemic sarcoidosis">Hypercalcemic sarcoidosis</a></span></li><li><span class="TLline"><a href="/medgen/19873" ref="tree=MeSH" title="MedGen record for Pulmonary sarcoidosis">Pulmonary sarcoidosis</a></span></li><li><span class="TLline"><a href="/medgen/19872" ref="tree=MeSH" title="MedGen record for Skin sarcoidosis">Skin sarcoidosis</a></span></li><li><span class="TLline"><a href="/medgen/22600" ref="tree=MeSH" title="MedGen record for Uveoparotid fever">Uveoparotid fever</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1648422" ref="tree=MeSH" title="MedGen record for Severe combined immunodeficiency due to CARMIL2 deficiency">Severe combined immunodeficiency due to CARMIL2 deficiency</a></span></li><li><span class="TLline"><a href="/medgen/1799982" ref="tree=MeSH" title="MedGen record for Severe combined immunodeficiency due to CD70 deficiency">Severe combined immunodeficiency due to CD70 deficiency</a></span></li><li><span class="TLline"><a href="/medgen/863232" ref="tree=MeSH" title="MedGen record for STAT3-related early-onset multisystem autoimmune disease">STAT3-related early-onset multisystem autoimmune disease</a></span></li><li><span class="TLline"><a href="/medgen/1791872" ref="tree=MeSH" title="MedGen record for T/NK-Cell Lymphoproliferative Disorder">T/NK-Cell Lymphoproliferative Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/277380" ref="tree=MeSH" title="MedGen record for Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder">Monomorphic T/NK-Cell Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/52890" ref="tree=MeSH" title="MedGen record for Tumor lysis syndrome">Tumor lysis syndrome</a></span></li><li><span class="TLline"><a href="/medgen/6174" ref="tree=MeSH" title="MedGen record for Waldenstrom macroglobulinemia">Waldenstrom macroglobulinemia</a></span><ul><li><span class="TLline"><a href="/medgen/422439" ref="tree=MeSH" title="MedGen record for Familial Waldenstrom Macroglobulinemia">Familial Waldenstrom Macroglobulinemia</a></span></li><li><span class="TLline"><a href="/medgen/320546" ref="tree=MeSH" title="MedGen record for Macroglobulinemia, Waldenstrom, 1">Macroglobulinemia, Waldenstrom, 1</a></span></li><li><span class="TLline"><a href="/medgen/355856" ref="tree=MeSH" title="MedGen record for Macroglobulinemia, Waldenstrom, 2">Macroglobulinemia, Waldenstrom, 2</a></span></li><li><span class="TLline"><a href="/medgen/762784" ref="tree=MeSH" title="MedGen record for Macroglobulinemia, Waldenstrom, somatic">Macroglobulinemia, Waldenstrom, somatic</a></span></li><li><span class="TLline"><a href="/medgen/167281" ref="tree=MeSH" title="MedGen record for Recurrent Waldenstrom Macroglobulinemia">Recurrent Waldenstrom Macroglobulinemia</a></span></li><li><span class="TLline"><a href="/medgen/1635976" ref="tree=MeSH" title="MedGen record for Refractory Waldenstrom Macroglobulinemia">Refractory Waldenstrom Macroglobulinemia</a></span></li><li><span class="TLline"><a href="/medgen/1650906" ref="tree=MeSH" title="MedGen record for Smoldering Waldenstrom Macroglobulinemia">Smoldering Waldenstrom Macroglobulinemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_21921"><div><strong>Wiskott-Aldrich syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21921</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0043194</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The WAS-related disorders, which include Wiskott-Aldrich syndrome, X-linked thrombocytopenia (XLT), and X-linked neutropenia (XLN), are a spectrum of disorders of hematopoietic cells, with predominant defects of platelets and lymphocytes. Wiskott-Aldrich syndrome usually presents in infancy. Affected males have thrombocytopenia with intermittent mucosal bleeding, bloody diarrhea, and intermittent or chronic petechiae and purpura; recurrent bacterial, viral, fungal, and/or opportunistic infections; and eczema. Approximately 25%-40% of those who survive the early complications develop one or more autoimmune conditions including hemolytic anemia, immune thrombocytopenic purpura, immune-mediated neutropenia, vasculitis, rheumatoid arthritis, and immune-mediated damage to the kidneys and liver. Individuals with a WAS-related disorder, particularly those who have been exposed to Epstein-Barr virus (EBV), are at increased risk of developing lymphomas, which often occur in unusual extranodal locations including the brain, lung, or gastrointestinal tract. Males with XLT have small platelet volume and thrombocytopenia. Severe disease-related events include severe bleeding episodes (14%), autoimmunity (12%), life-threatening infections (7%), and malignancy (5%). Males with XLN typically have congenital neutropenia associated with myelodysplasia, hyperactive neutrophils, increased myeloid cell apoptosis, and lymphoid cell abnormalities.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/21921">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_124417"><div><strong>Reticular dysgenesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>124417</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0272167</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Reticular dysgenesis, the most severe form of inborn severe combined immunodeficiency (SCID), is characterized by absence of granulocytes and almost complete deficiency of lymphocytes in peripheral blood, hypoplasia of the thymus and secondary lymphoid organs, and lack of innate and adaptive humoral and cellular immune functions, leading to fatal septicemia within days after birth (summary by Pannicke et al., 2009).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/124417">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_351256"><div><strong>Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>351256</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1864947</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Immunodeficiency-54 is an autosomal recessive primary immunodeficiency characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of natural killer (NK) cells, and recurrent viral infections, most often affecting the respiratory tract and leading to respiratory failure. Affected individuals also have adrenal insufficiency requiring corticosteroid replacement therapy and may have an increased susceptibility to cancer. Laboratory studies of patient cells showed a DNA repair defect (summary by Gineau et al., 2012).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/351256">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_382434"><div><strong>Autoimmune lymphoproliferative syndrome type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2674723</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">RAS-associated leukoproliferative disorder (RALD) is characterized by lymphadenopathy, splenomegaly, and variable autoimmune phenomena, including autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, and neutropenia. Laboratory studies show an expansion of lymphocytes due to defective apoptosis, as well as significant autoantibodies. Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010). The disorder shows significant overlap with autoimmune lymphoproliferative syndrome (ALPS; 601859) and was originally designated ALPS IV.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/382434">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_477076"><div><strong>X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477076</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3275445</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">XMEN is an X-linked recessive immunodeficiency characterized by CD4 (186940) lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation (Li et al., 2011). Affected individuals have chronic Epstein-Barr virus (EBV) infection and are susceptible to the development of EBV-associated B-cell lymphoproliferative disorders. Magnesium supplementation may be therapeutic (summary by Li et al., 2014).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/477076">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_765548"><div><strong>Lymphoproliferative syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>765548</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3552634</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lymphoproliferative syndrome-1 is an autosomal recessive primary immunodeficiency characterized by onset in early childhood of Epstein-Barr virus (EBV)-associated immune dysregulation, manifest as lymphoma, lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis, Hodgkin disease, and/or hypogammaglobulinemia. Autoimmune disorders, such as autoimmune hemolytic anemia or renal disease, may also occur. Patients show a high EBV viral load and decreased invariant natural killer T cells. It is unknown whether patients with ITK mutations are intrinsically susceptible to development of lymphoma or dysgammaglobulinemia in the absence of EBV infection (summary by Stepensky et al., 2011; Linka et al., 2012). For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/765548">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766426"><div><strong>Combined immunodeficiency due to LRBA deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766426</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553512</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Common variable immunodeficiency-8 with autoimmunity is an autosomal recessive disorder of immune dysregulation. Affected individuals have early childhood onset of recurrent infections, particularly respiratory infections, and also develop variable autoimmune disorders, including idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and inflammatory bowel disease. The presentation and phenotype are highly variable, even within families (summary by Lopez-Herrera et al., 2012 and Alangari et al., 2012). Immunologic findings are also variable and may include decreased B cells, hypogammaglobulinemia, and deficiency of CD4+ T regulatory (Treg) cells (Charbonnier et al., 2015). For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (607594).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766426">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766857"><div><strong>Combined immunodeficiency due to STK4 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766857</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553943</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-110 (IMD110) is an autosomal recessive primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, and autoimmune manifestations. Patients are at risk for developing lymphoproliferative disorders or lymphoma, particularly associated with EBV. Some patients may show cardiac malformations, including atrial septal defect (Abdollahpour et al., 2012; Nehme et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766857">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767454"><div><strong>Lymphoproliferative syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767454</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554540</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lymphoproliferative syndrome-2, also known as CD27 deficiency, is an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impairment in specific antibody function resulting from impaired T cell-dependent B-cell responses and T-cell dysfunction (summary by van Montfrans et al., 2012). The phenotype can vary significantly, from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation (summary by Salzer et al., 2013). For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767454">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816258"><div><strong>Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816258</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809928</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune lymphoproliferative syndrome type III is an autosomal recessive disorder of immune dysregulation. The phenotype is variable, but most patients have significant lymphadenopathy associated with variable autoimmune manifestations. Some patients may have recurrent infections. Lymphocyte accumulation results from a combination of impaired apoptosis and excessive proliferation (summary by Oliveira, 2013). For a general description and a discussion of genetic heterogeneity of ALPS, see 601859.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816258">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_854497"><div><strong>Vasculitis due to ADA2 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854497</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3887654</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Adenosine deaminase 2 deficiency (DADA2) is a complex systemic autoinflammatory disorder in which vasculopathy/vasculitis, dysregulated immune function, and/or hematologic abnormalities may predominate. Inflammatory features include intermittent fevers, rash (often livedo racemosa/reticularis), and musculoskeletal involvement (myalgia/arthralgia, arthritis, myositis). Vasculitis, which usually begins before age ten years, may manifest as early-onset ischemic (lacunar) and/or hemorrhagic strokes, or as cutaneous or systemic polyarteritis nodosa. Hypertension and hepatosplenomegaly are often found. More severe involvement may lead to progressive central neurologic deficits (dysarthria, ataxia, cranial nerve palsies, cognitive impairment) or to ischemic injury to the kidney, intestine, and/or digits. Dysregulation of immune function can lead to immunodeficiency or autoimmunity of varying severity; lymphadenopathy may be present and some affected individuals have had lymphoproliferative disease. Hematologic disorders may begin early in life or in late adulthood, and can include lymphopenia, neutropenia, pure red cell aplasia, thrombocytopenia, or pancytopenia. Of note, both interfamilial and intrafamilial phenotypic variability (e.g., in age of onset, frequency and severity of manifestations) can be observed; also, individuals with biallelic ADA2 pathogenic variants may remain asymptomatic until adulthood or may never develop clinical manifestations of DADA2.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/854497">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863054"><div><strong>Severe combined immunodeficiency due to CTPS1 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863054</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014617</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IMD24 is an autosomal recessive immunodeficiency characterized by the impaired capacity of activated T and B cells to proliferate in response to antigen receptor-mediated activation. Patients have early onset of severe chronic viral infections, mostly caused by herpesviruses, including Epstein-Barr virus (EBV) and varicella zoster virus (VZV); they also suffer from recurrent encapsulated bacterial infections, a spectrum typical of a combined deficiency of adaptive immunity (CID) (summary by Martin et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863054">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1799982"><div><strong>Severe combined immunodeficiency due to CD70 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1799982</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5568559</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lymphoproliferative syndrome-3 (LPFS3) is an autosomal recessive early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus (EBV) infection in B cells, resulting in abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have hypogammaglobulinemia without lymphopenia, although some subsets of immune cells may be low and some patients may have recurrent infections. The disorder results from impaired signaling from proliferating B cells to effector T cells that provide immune surveillance. There may be an increased risk of solid tumors in heterozygous carriers (summary by Abolhassani et al., 2017). For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1799982">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816258" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766426" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined immunodeficiency due to LRBA deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766857" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined immunodeficiency due to STK4 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_765548" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoproliferative syndrome 1</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (13)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767454" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoproliferative syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_351256" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_124417" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Reticular dysgenesis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1799982" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Severe combined immunodeficiency due to CD70 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863054" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Severe combined immunodeficiency due to CTPS1 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854497" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vasculitis due to ADA2 deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_21921" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wiskott-Aldrich syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477076" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia</a></div></span></div></div>
|
||
</div>
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|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36946218">Post-transplant lymphoproliferative disorder: Update on treatment and novel therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Atallah-Yunes SA,
|
||
Salman O,
|
||
Robertson MJ</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
2023 May;201(3):383-395.
|
||
Epub 2023 Mar 22
|
||
doi: 10.1111/bjh.18763.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36946218" target="_blank">36946218</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36255040">Follicular lymphoma: 2023 update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobsen E</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2022 Dec;97(12):1638-1651.
|
||
Epub 2022 Oct 18
|
||
doi: 10.1002/ajh.26737.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36255040" target="_blank">36255040</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31814159">Follicular lymphoma: 2020 update on diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Freedman A,
|
||
Jacobsen E</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2020 Mar;95(3):316-327.
|
||
Epub 2019 Dec 22
|
||
doi: 10.1002/ajh.25696.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31814159" target="_blank">31814159</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22lymphoproliferative%20disorder%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (258)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37540819">How I treat posttransplant lymphoproliferative disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Amengual JE,
|
||
Pro B</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2023 Oct 26;142(17):1426-1437.
|
||
doi: 10.1182/blood.2023020075.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37540819" target="_blank">37540819</a><a href="/pmc/articles/PMC10731918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36946218">Post-transplant lymphoproliferative disorder: Update on treatment and novel therapies.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Atallah-Yunes SA,
|
||
Salman O,
|
||
Robertson MJ</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
2023 May;201(3):383-395.
|
||
Epub 2023 Mar 22
|
||
doi: 10.1111/bjh.18763.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36946218" target="_blank">36946218</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31352991">Castleman Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang W,
|
||
Medeiros LJ</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2019 Sep;12(3):849-863.
|
||
Epub 2019 May 23
|
||
doi: 10.1016/j.path.2019.03.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31352991" target="_blank">31352991</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29157613">Castleman Disease Pathogenesis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fajgenbaum DC,
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<div class="nl"><a target="_blank" href="/pubmed/23618626">Paraproteinemic neuropathies.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rojas-García R,
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<div class="nl"><a target="_blank" href="/pubmed/37162742">Important Considerations in the Diagnosis and Management of Post-transplant Lymphoproliferative Disorder.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37495287">Immediate and Late Complications After Liver Transplantation.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31814159">Follicular lymphoma: 2020 update on diagnosis and management.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/31814159" target="_blank">31814159</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29282771">Consistency of the Moreau CLL score.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sorigue M,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lymphoproliferative%20disorder%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (867)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/37574195">Central Nervous System Lymphoproliferative Disorder Secondary to Methotrexate: A Systematic Literature Review and Case Illustration.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">In A,
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Stopa BM,
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Cuoco JA,
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Stump MS,
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<div class="nl"><a target="_blank" href="/pubmed/32307569">Germinotropic lymphoproliferative disorder: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zanelli M,
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Zizzo M,
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Bisagni A,
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Froio E,
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De Marco L,
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Valli R,
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Filosa A,
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Luminari S,
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Martino G,
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Fratoni S,
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<div class="nl"><a target="_blank" href="/pubmed/29579330">Impact of the posttransplant lymphoproliferative disorder subtype on survival.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Koff JL,
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Li JX,
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Zhang X,
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Switchenko JM,
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<div class="nl"><a target="_blank" href="/pubmed/29517815">Systematic review and meta-analysis of post-transplant lymphoproliferative disorder in lung transplant recipients.</a></div>
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Glanville AR,
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|
||
<span class="bold">PMID: </span><a href="/pubmed/22157133" target="_blank">22157133</a><a href="/pmc/articles/PMC3273364" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lymphoproliferative%20disorder%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0024314%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (9)</a></li>
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<li><a href="/gtr/tests?term=C0024314%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (10)</a></li>
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<li><a href="/gtr/tests?term=C0024314%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (13)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0024314%5bDISCUI%5d" target="_blank">See all (23)</a></total></li>
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