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<meta name="keywords" content="C0014175, disease or syndrome, endometrioses, endometriosis, endometriosis (clinical), endometriosis (disease), autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The growth of endometrial tissue outside the uterus." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=8620
ConceptID=C0014175
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Endometriosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8620</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0014175</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Endometriosis (disease)</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Endometriosis (396224008); Endometriosis (129103003); Endometriosis (clinical) (129103003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030127">HP:0030127</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0005133" target="_blank">MONDO:0005133</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">The growth of endometrial tissue outside the uterus. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014175[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=8620">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=8620" ref="ncbi_uid=8620">V</a></span></span><span class="TLline">Endometriosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/866746" ref="tree=MeSH" title="MedGen record for Abnormal reproductive system morphology">Abnormal reproductive system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/869393" ref="tree=MeSH" title="MedGen record for Abnormality of the female genitalia">Abnormality of the female genitalia</a></span><ul><li><span class="TLline"><a href="/medgen/871402" ref="tree=MeSH" title="MedGen record for Abnormal morphology of female internal genitalia">Abnormal morphology of female internal genitalia</a></span><ul><li><span class="TLline"><a href="/medgen/78598" ref="tree=MeSH" title="MedGen record for Congenital uterine anomaly">Congenital uterine anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/1371444" ref="tree=MeSH" title="MedGen record for Abnormal uterus morphology">Abnormal uterus morphology</a></span><ul><li><span class="TLline"><a href="/medgen/868228" ref="tree=MeSH" title="MedGen record for Abnormal endometrium morphology">Abnormal endometrium morphology</a></span><ul><li><span class="matched_ds">Endometriosis</span><ul><li><span class="TLline"><a href="/medgen/927487" ref="tree=MeSH" title="MedGen record for Atypical Endometriosis">Atypical Endometriosis</a></span></li><li><span class="TLline"><a href="/medgen/78705" ref="tree=MeSH" title="MedGen record for Cervical endometriosis">Cervical endometriosis</a></span></li><li><span class="TLline"><a href="/medgen/923893" ref="tree=MeSH" title="MedGen record for Endometriosis of thorax">Endometriosis of thorax</a></span></li><li><span class="TLline"><a href="/medgen/41788" ref="tree=MeSH" title="MedGen record for Fallopian tube endometriosis">Fallopian tube endometriosis</a></span></li><li><span class="TLline"><a href="/medgen/102350" ref="tree=MeSH" title="MedGen record for Ovarian endometriosis">Ovarian endometriosis</a></span></li><li><span class="TLline"><a href="/medgen/924096" ref="tree=MeSH" title="MedGen record for Vaginal Endometriosis">Vaginal Endometriosis</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_338749"><div><strong>Endometriosis, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338749</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1851649</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove nowrap">See: <a href="/medgen/338749">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_462289"><div><strong>THOC6-related developmental delay-microcephaly-facial dysmorphism syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462289</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3150939</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">THOC6 intellectual disability syndrome is associated with moderate-to-severe developmental delay or intellectual disability; nonspecific dysmorphic facial features (tall forehead, deep-set eyes, short and upslanted palpebral fissures, epicanthal folds, and long nose with low-hanging columella); microcephaly (typically 2-3 SD below the mean); teeth anomalies (dental caries, malocclusion, and supernumerary teeth); cardiac anomalies (most typically atrial and/or ventricular septal defects); prenatal ventriculomegaly and hydrocephalus; cryptorchidism in males; and renal malformations (most commonly unilateral renal agenesis). More rarely, affected individuals may have hypergonadotropic hypogonadism (in females), seizures, poor growth, feeding difficulties, hearing loss, refractive errors and/or other eye abnormalities, vertebral anomalies, micro/retrognathia, and imperforate / anteriorly placed anus.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/462289">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_854714"><div><strong>Hermansky-Pudlak syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854714</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3888007</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Hermansky-Pudlak syndrome (HPS) is characterized by oculocutaneous albinism, a bleeding diathesis, and, in some individuals, pulmonary fibrosis, granulomatous colitis, and/or immunodeficiency. Ocular findings include nystagmus, reduced iris pigment, reduced retinal pigment, foveal hypoplasia with significant reduction in visual acuity (usually in the range of 20/50 to 20/400), and strabismus in many individuals. Hair color ranges from white to brown; skin color ranges from white to olive and is usually at least a shade lighter than that of other family members. The bleeding diathesis can result in variable degrees of bruising, epistaxis, gingival bleeding, postpartum hemorrhage, colonic bleeding, and prolonged bleeding with menses or after tooth extraction, circumcision, and/or other surgeries. Pulmonary fibrosis, colitis, and/or neutropenia have been reported in individuals with pathogenic variants in some HPS-related genes. Pulmonary fibrosis, a restrictive lung disease, typically causes symptoms in the early 30s and can progress to death within a decade. Granulomatous colitis is severe in about 15% of affected individuals. Neutropenia and/or immune defects occur primarily in individuals with pathogenic variants in AP3B1 and AP3D1.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/854714">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338749" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Endometriosis, susceptibility to, 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854714" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hermansky-Pudlak syndrome 6</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462289" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">THOC6-related developmental delay-microcephaly-facial dysmorphism syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36375827">Pathophysiology, diagnosis, and management of endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Horne AW,
Missmer SA</span><br />
<span class="medgenPMjournal">BMJ</span>
2022 Nov 14;379:e070750.
doi: 10.1136/bmj-2022-070750.
<span class="bold">PMID: </span><a href="/pubmed/36375827" target="_blank">36375827</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34228062">Diagnosis and Management of Infertility: A Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Carson SA,
Kallen AN</span><br />
<span class="medgenPMjournal">JAMA</span>
2021 Jul 6;326(1):65-76.
doi: 10.1001/jama.2021.4788.
<span class="bold">PMID: </span><a href="/pubmed/34228062" target="_blank">34228062</a><a href="/pmc/articles/PMC9302705" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31069056">Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rolla E</span><br />
<span class="medgenPMjournal">F1000Res</span>
2019;8
Epub 2019 Apr 23
doi: 10.12688/f1000research.14817.1.
<span class="bold">PMID: </span><a href="/pubmed/31069056" target="_blank">31069056</a><a href="/pmc/articles/PMC6480968" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22endometriosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1526)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng193" target="_blank">UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36375827">Pathophysiology, diagnosis, and management of endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Horne AW,
Missmer SA</span><br />
<span class="medgenPMjournal">BMJ</span>
2022 Nov 14;379:e070750.
doi: 10.1136/bmj-2022-070750.
<span class="bold">PMID: </span><a href="/pubmed/36375827" target="_blank">36375827</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34718567">The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Salliss ME,
Farland LV,
Mahnert ND,
Herbst-Kralovetz MM</span><br />
<span class="medgenPMjournal">Hum Reprod Update</span>
2021 Dec 21;28(1):92-131.
doi: 10.1093/humupd/dmab035.
<span class="bold">PMID: </span><a href="/pubmed/34718567" target="_blank">34718567</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31951524">SnapShot: Endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Horne AW,
Saunders PTK</span><br />
<span class="medgenPMjournal">Cell</span>
2019 Dec 12;179(7):1677-1677.e1.
doi: 10.1016/j.cell.2019.11.033.
<span class="bold">PMID: </span><a href="/pubmed/31951524" target="_blank">31951524</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29420391">Clinical Management of Endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Falcone T,
Flyckt R</span><br />
<span class="medgenPMjournal">Obstet Gynecol</span>
2018 Mar;131(3):557-571.
doi: 10.1097/AOG.0000000000002469.
<span class="bold">PMID: </span><a href="/pubmed/29420391" target="_blank">29420391</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28271702">Update on endometriosis pathogenesis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Czyzyk A,
Podfigurna A,
Szeliga A,
Meczekalski B</span><br />
<span class="medgenPMjournal">Minerva Ginecol</span>
2017 Oct;69(5):447-461.
Epub 2017 Mar 7
doi: 10.23736/S0026-4784.17.04048-5.
<span class="bold">PMID: </span><a href="/pubmed/28271702" target="_blank">28271702</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10371)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36387918">Endometriosis-associated infertility: From pathophysiology to tailored treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bonavina G,
Taylor HS</span><br />
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
2022;13:1020827.
Epub 2022 Oct 26
doi: 10.3389/fendo.2022.1020827.
<span class="bold">PMID: </span><a href="/pubmed/36387918" target="_blank">36387918</a><a href="/pmc/articles/PMC9643365" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36375827">Pathophysiology, diagnosis, and management of endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Horne AW,
Missmer SA</span><br />
<span class="medgenPMjournal">BMJ</span>
2022 Nov 14;379:e070750.
doi: 10.1136/bmj-2022-070750.
<span class="bold">PMID: </span><a href="/pubmed/36375827" target="_blank">36375827</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34899597">Pathogenesis Based Diagnosis and Treatment of Endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Koninckx PR,
Fernandes R,
Ussia A,
Schindler L,
Wattiez A,
Al-Suwaidi S,
Amro B,
Al-Maamari B,
Hakim Z,
Tahlak M</span><br />
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
2021;12:745548.
Epub 2021 Nov 25
doi: 10.3389/fendo.2021.745548.
<span class="bold">PMID: </span><a href="/pubmed/34899597" target="_blank">34899597</a><a href="/pmc/articles/PMC8656967" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33640070">Endometriosis is a chronic systemic disease: clinical challenges and novel innovations.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Taylor HS,
Kotlyar AM,
Flores VA</span><br />
<span class="medgenPMjournal">Lancet</span>
2021 Feb 27;397(10276):839-852.
doi: 10.1016/S0140-6736(21)00389-5.
<span class="bold">PMID: </span><a href="/pubmed/33640070" target="_blank">33640070</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31069056">Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rolla E</span><br />
<span class="medgenPMjournal">F1000Res</span>
2019;8
Epub 2019 Apr 23
doi: 10.12688/f1000research.14817.1.
<span class="bold">PMID: </span><a href="/pubmed/31069056" target="_blank">31069056</a><a href="/pmc/articles/PMC6480968" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10063)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36716811">Efficacy of acupuncture for endometriosis-associated pain: a multicenter randomized single-blind placebo-controlled trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li PS,
Peng XM,
Niu XX,
Xu L,
Hung Yu Ng E,
Wang CC,
Dai JF,
Lu J,
Liang RN</span><br />
<span class="medgenPMjournal">Fertil Steril</span>
2023 May;119(5):815-823.
Epub 2023 Jan 27
doi: 10.1016/j.fertnstert.2023.01.034.
<span class="bold">PMID: </span><a href="/pubmed/36716811" target="_blank">36716811</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34627209">Effect of physical activity and exercise on endometriosis-associated symptoms: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tennfjord MK,
Gabrielsen R,
Tellum T</span><br />
<span class="medgenPMjournal">BMC Womens Health</span>
2021 Oct 9;21(1):355.
doi: 10.1186/s12905-021-01500-4.
<span class="bold">PMID: </span><a href="/pubmed/34627209" target="_blank">34627209</a><a href="/pmc/articles/PMC8502311" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34122682">The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Amini L,
Chekini R,
Nateghi MR,
Haghani H,
Jamialahmadi T,
Sathyapalan T,
Sahebkar A</span><br />
<span class="medgenPMjournal">Pain Res Manag</span>
2021;2021:5529741.
Epub 2021 May 26
doi: 10.1155/2021/5529741.
<span class="bold">PMID: </span><a href="/pubmed/34122682" target="_blank">34122682</a><a href="/pmc/articles/PMC8172324" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33206374">Pre- and postsurgical medical therapy for endometriosis surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chen I,
Veth VB,
Choudhry AJ,
Murji A,
Zakhari A,
Black AY,
Agarpao C,
Maas JW</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2020 Nov 18;11(11):CD003678.
doi: 10.1002/14651858.CD003678.pub3.
<span class="bold">PMID: </span><a href="/pubmed/33206374" target="_blank">33206374</a><a href="/pmc/articles/PMC8127059" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29974615">Management of primary spontaneous pneumothorax: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wong A,
Galiabovitch E,
Bhagwat K</span><br />
<span class="medgenPMjournal">ANZ J Surg</span>
2019 Apr;89(4):303-308.
Epub 2018 Jul 5
doi: 10.1111/ans.14713.
<span class="bold">PMID: </span><a href="/pubmed/29974615" target="_blank">29974615</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6410)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/39018030">Endometriosis Typology and Ovarian Cancer Risk.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barnard ME,
Farland LV,
Yan B,
Wang J,
Trabert B,
Doherty JA,
Meeks HD,
Madsen M,
Guinto E,
Collin LJ,
Maurer KA,
Page JM,
Kiser AC,
Varner MW,
Allen-Brady K,
Pollack AZ,
Peterson KR,
Peterson CM,
Schliep KC</span><br />
<span class="medgenPMjournal">JAMA</span>
2024 Aug 13;332(6):482-489.
doi: 10.1001/jama.2024.9210.
<span class="bold">PMID: </span><a href="/pubmed/39018030" target="_blank">39018030</a><a href="/pmc/articles/PMC11255975" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32949284">Endometriosis and irritable bowel syndrome: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chiaffarino F,
Cipriani S,
Ricci E,
Mauri PA,
Esposito G,
Barretta M,
Vercellini P,
Parazzini F</span><br />
<span class="medgenPMjournal">Arch Gynecol Obstet</span>
2021 Jan;303(1):17-25.
Epub 2020 Sep 19
doi: 10.1007/s00404-020-05797-8.
<span class="bold">PMID: </span><a href="/pubmed/32949284" target="_blank">32949284</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30017581">Risk for and consequences of endometriosis: A critical epidemiologic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shafrir AL,
Farland LV,
Shah DK,
Harris HR,
Kvaskoff M,
Zondervan K,
Missmer SA</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Obstet Gynaecol</span>
2018 Aug;51:1-15.
Epub 2018 Jul 3
doi: 10.1016/j.bpobgyn.2018.06.001.
<span class="bold">PMID: </span><a href="/pubmed/30017581" target="_blank">30017581</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29401293">Fruit and vegetable consumption and risk of endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harris HR,
Eke AC,
Chavarro JE,
Missmer SA</span><br />
<span class="medgenPMjournal">Hum Reprod</span>
2018 Apr 1;33(4):715-727.
doi: 10.1093/humrep/dey014.
<span class="bold">PMID: </span><a href="/pubmed/29401293" target="_blank">29401293</a><a href="/pmc/articles/PMC6018917" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27282512">Lethal Epistaxis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Byard RW</span><br />
<span class="medgenPMjournal">J Forensic Sci</span>
2016 Sep;61(5):1244-9.
Epub 2016 Jun 10
doi: 10.1111/1556-4029.13119.
<span class="bold">PMID: </span><a href="/pubmed/27282512" target="_blank">27282512</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3767)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38414426">Chronic postsurgical pain: A European survey.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martinez V,
Lehman T,
Lavand'homme P,
Harkouk H,
Kalso E,
Pogatzki-Zahn EM,
Komann M,
Meissner W,
Weinmann C,
Fletcher D</span><br />
<span class="medgenPMjournal">Eur J Anaesthesiol</span>
2024 May 1;41(5):351-362.
Epub 2024 Feb 27
doi: 10.1097/EJA.0000000000001974.
<span class="bold">PMID: </span><a href="/pubmed/38414426" target="_blank">38414426</a><a href="/pmc/articles/PMC10990022" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29566851">Role of transvaginal sonography and magnetic resonance imaging in the diagnosis of uterine adenomyosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bazot M,
Daraï E</span><br />
<span class="medgenPMjournal">Fertil Steril</span>
2018 Mar;109(3):389-397.
doi: 10.1016/j.fertnstert.2018.01.024.
<span class="bold">PMID: </span><a href="/pubmed/29566851" target="_blank">29566851</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29202963">Diagnosis of deep endometriosis: clinical examination, ultrasonography, magnetic resonance imaging, and other techniques.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bazot M,
Daraï E</span><br />
<span class="medgenPMjournal">Fertil Steril</span>
2017 Dec;108(6):886-894.
doi: 10.1016/j.fertnstert.2017.10.026.
<span class="bold">PMID: </span><a href="/pubmed/29202963" target="_blank">29202963</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28189296">Biomarkers in endometriosis: challenges and opportunities.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ahn SH,
Singh V,
Tayade C</span><br />
<span class="medgenPMjournal">Fertil Steril</span>
2017 Mar;107(3):523-532.
Epub 2017 Feb 8
doi: 10.1016/j.fertnstert.2017.01.009.
<span class="bold">PMID: </span><a href="/pubmed/28189296" target="_blank">28189296</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22305456">Ovarian incidentaloma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Solnik MJ,
Alexander C</span><br />
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
2012 Feb;26(1):105-16.
doi: 10.1016/j.beem.2011.07.002.
<span class="bold">PMID: </span><a href="/pubmed/22305456" target="_blank">22305456</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6177)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37644533">Antioxidant vitamins supplementation reduce endometriosis related pelvic pain in humans: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng SH,
Chen XX,
Chen Y,
Wu ZC,
Chen XQ,
Li XL</span><br />
<span class="medgenPMjournal">Reprod Biol Endocrinol</span>
2023 Aug 29;21(1):79.
doi: 10.1186/s12958-023-01126-1.
<span class="bold">PMID: </span><a href="/pubmed/37644533" target="_blank">37644533</a><a href="/pmc/articles/PMC10464024" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36571475">Benefits of physical therapy in improving quality of life and pain associated with endometriosis: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Abril-Coello R,
Correyero-León M,
Ceballos-Laita L,
Jiménez-Barrio S</span><br />
<span class="medgenPMjournal">Int J Gynaecol Obstet</span>
2023 Jul;162(1):233-243.
Epub 2023 Jan 17
doi: 10.1002/ijgo.14645.
<span class="bold">PMID: </span><a href="/pubmed/36571475" target="_blank">36571475</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36138433">Food groups and nutrients consumption and risk of endometriosis: a systematic review and meta-analysis of observational studies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Arab A,
Karimi E,
Vingrys K,
Kelishadi MR,
Mehrabani S,
Askari G</span><br />
<span class="medgenPMjournal">Nutr J</span>
2022 Sep 22;21(1):58.
doi: 10.1186/s12937-022-00812-x.
<span class="bold">PMID: </span><a href="/pubmed/36138433" target="_blank">36138433</a><a href="/pmc/articles/PMC9503255" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34627209">Effect of physical activity and exercise on endometriosis-associated symptoms: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tennfjord MK,
Gabrielsen R,
Tellum T</span><br />
<span class="medgenPMjournal">BMC Womens Health</span>
2021 Oct 9;21(1):355.
doi: 10.1186/s12905-021-01500-4.
<span class="bold">PMID: </span><a href="/pubmed/34627209" target="_blank">34627209</a><a href="/pmc/articles/PMC8502311" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31454452">Endometriosis and the microbiome: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Leonardi M,
Hicks C,
El-Assaad F,
El-Omar E,
Condous G</span><br />
<span class="medgenPMjournal">BJOG</span>
2020 Jan;127(2):239-249.
Epub 2019 Sep 19
doi: 10.1111/1471-0528.15916.
<span class="bold">PMID: </span><a href="/pubmed/31454452" target="_blank">31454452</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Endometriosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (676)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0014175%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
<li><a href="/gtr/tests?term=C0014175%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0014175%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22endometriosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Endometriosis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng193">NICE, 2021</a><div>UK NICE Guideline NG193, Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain, 2021</div></li></ul></div>
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