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<meta name="keywords" content="C0007384, attack, cataleptic, attacks, cataleptic, cataleptic attack, cataleptic attacks, cataplexy, disease or syndrome, henneberg syndrome, syndrome, henneberg, syndrome, tonelessness, syndromes, tonelessness, tonelessness syndrome, tonelessness syndromes, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=2862
|
||
ConceptID=C0007384
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Cataplexy</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2862</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0007384</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Attack, Cataleptic; Attacks, Cataleptic; Cataleptic Attack; Cataleptic Attacks; Henneberg Syndrome; Syndrome, Henneberg; Syndrome, Tonelessness; Syndromes, Tonelessness; Tonelessness Syndrome; Tonelessness Syndromes</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Cataplexy (46263000)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002524">HP:0002524</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/161400" target="_blank">161400</a></td></tr>
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||
<div class="portlet_content ln">A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=2862" target="_blank" href="/omim/161400">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=2862" ref="ncbi_uid=2862">V</a></span></span><span class="TLline">Cataplexy</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/871309" ref="tree=MeSH" title="MedGen record for Abnormality of prenatal development or birth">Abnormality of prenatal development or birth</a></span><ul><li><span class="TLline"><a href="/medgen/1254" ref="tree=MeSH" title="MedGen record for Fetal anomaly">Fetal anomaly</a></span><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/105425" ref="tree=MeSH" title="MedGen record for Abnormality of the nervous system">Abnormality of the nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/868417" ref="tree=MeSH" title="MedGen record for Abnormal nervous system physiology">Abnormal nervous system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868940" ref="tree=MeSH" title="MedGen record for Abnormal central motor function">Abnormal central motor function</a></span><ul><li><span class="matched_ds">Cataplexy</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_371809"><div><strong>Narcolepsy 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>371809</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834372</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Adie (1926) first delineated narcolepsy as a separate and specific entity. It is a sleep disorder characterized by attacks of disabling daytime drowsiness and low alertness. The normal physiologic components of rapid eye movement (REM) sleep, dreaming and loss of muscle tone, are separated and also occur while the subject is awake, resulting in half-sleep dreams and episodes of skeletal muscle paralysis and atonia (cataplexy and sleep paralysis). Unlike normal sleep, that of narcolepsy often begins with REM activity and the time taken to fall asleep is shorter than normal. In contrast to animal models, human narcolepsy is not a simple genetic disorder. Most human cases of narcolepsy are sporadic and carry a specific HLA haplotype (Peyron et al., 2000). Familial cases are the exception rather than the rule, and monozygotic twins show only partial concordance (25 to 31%) (Mignot, 1998). Genetic Heterogeneity of Narcolepsy Additional narcolepsy loci have been mapped to chromosomes 4 (NRCLP2; 605841), 21q (NRCLP3; 609039), 22q13 (NRCLP4; 612417), 14q11 (NRCLP5; 612851), and 19p13.2 (NRCLP6; 614223). NRCLP7 (614250) is caused by mutation in the MOG gene (159465) on chromosome 6p22. Resistance to narcolepsy is associated with minor alleles of a SNP and a marker in the NLC1A gene (610259) on chromosome 21q22.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/371809">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_332320"><div><strong>Narcolepsy 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332320</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836907</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Narcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.\n\nNarcolepsy is characterized by excessive daytime sleepiness. Affected individuals feel tired during the day, and several times a day they may experience an overwhelming urge to sleep. "Sleep attacks" can occur at unusual times, such as during a meal or in the middle of a conversation. They last from a few seconds to a few minutes and often lead to a longer nap, after which affected individuals wake up feeling refreshed.\n\nAnother common feature of narcolepsy is cataplexy, which is a sudden loss of muscle tone in response to strong emotion (such as laughing, surprise, or anger). These episodes of muscle weakness can cause an affected person to slump over or fall, which occasionally leads to injury. Episodes of cataplexy usually last just a few seconds, and they may occur from several times a day to a few times a year. Most people diagnosed with narcolepsy also have cataplexy. However, some do not, which has led researchers to distinguish two major forms of the condition: narcolepsy with cataplexy and narcolepsy without cataplexy.\n\nNarcolepsy also affects nighttime sleep. Most affected individuals have trouble sleeping for more than a few hours at night. They often experience vivid hallucinations while falling asleep (hypnogogic hallucinations) or while waking up (hypnopompic hallucinations). Affected individuals often have realistic and distressing dreams, and they may act out their dreams by moving excessively or talking in their sleep. Many people with narcolepsy also experience sleep paralysis, which is an inability to move or speak for a short period while falling asleep or awakening. The combination of hallucinations, vivid dreams, and sleep paralysis is often frightening and unpleasant for affected individuals.\n\nSome people with narcolepsy have all of the major features of the disorder, while others have only one or two. Most of the signs and symptoms persist throughout life, although episodes of cataplexy may become less frequent with age and treatment.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332320">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_335942"><div><strong>Niemann-Pick disease, type C2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>335942</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1843366</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Niemann-Pick disease type C (NPC) is a slowly progressive lysosomal disorder whose principal manifestations are age dependent. The manifestations in the perinatal period and infancy are predominantly visceral, with hepatosplenomegaly, jaundice, and (in some instances) pulmonary infiltrates. From late infancy onward, the presentation is dominated by neurologic manifestations. The youngest children may present with hypotonia and developmental delay, with the subsequent emergence of ataxia, dysarthria, dysphagia, and, in some individuals, epileptic seizures, dystonia, and gelastic cataplexy. Although cognitive impairment may be subtle at first, it eventually becomes apparent that affected individuals have a progressive dementia. Older teenagers and young adults may present predominantly with apparent early-onset dementia or psychiatric manifestations; however, careful examination usually identifies typical neurologic signs.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/335942">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_465922"><div><strong>Niemann-Pick disease, type C1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>465922</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3179455</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Niemann-Pick disease type C (NPC) is a slowly progressive lysosomal disorder whose principal manifestations are age dependent. The manifestations in the perinatal period and infancy are predominantly visceral, with hepatosplenomegaly, jaundice, and (in some instances) pulmonary infiltrates. From late infancy onward, the presentation is dominated by neurologic manifestations. The youngest children may present with hypotonia and developmental delay, with the subsequent emergence of ataxia, dysarthria, dysphagia, and, in some individuals, epileptic seizures, dystonia, and gelastic cataplexy. Although cognitive impairment may be subtle at first, it eventually becomes apparent that affected individuals have a progressive dementia. Older teenagers and young adults may present predominantly with apparent early-onset dementia or psychiatric manifestations; however, careful examination usually identifies typical neurologic signs.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/465922">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_481896"><div><strong>Narcolepsy 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481896</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280266</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Some people with narcolepsy have all of the major features of the disorder, while others have only one or two. Most of the signs and symptoms persist throughout life, although episodes of cataplexy may become less frequent with age and treatment.\n\nNarcolepsy also affects nighttime sleep. Most affected individuals have trouble sleeping for more than a few hours at night. They often experience vivid hallucinations while falling asleep (hypnogogic hallucinations) or while waking up (hypnopompic hallucinations). Affected individuals often have realistic and distressing dreams, and they may act out their dreams by moving excessively or talking in their sleep. Many people with narcolepsy also experience sleep paralysis, which is an inability to move or speak for a short period while falling asleep or awakening. The combination of hallucinations, vivid dreams, and sleep paralysis is often frightening and unpleasant for affected individuals.\n\nAnother common feature of narcolepsy is cataplexy, which is a sudden loss of muscle tone in response to strong emotion (such as laughing, surprise, or anger). These episodes of muscle weakness can cause an affected person to slump over or fall, which occasionally leads to injury. Episodes of cataplexy usually last just a few seconds, and they may occur from several times a day to a few times a year. Most people diagnosed with narcolepsy also have cataplexy. However, some do not, which has led researchers to distinguish two major forms of the condition: narcolepsy with cataplexy and narcolepsy without cataplexy.\n\nNarcolepsy is characterized by excessive daytime sleepiness. Affected individuals feel tired during the day, and several times a day they may experience an overwhelming urge to sleep. "Sleep attacks" can occur at unusual times, such as during a meal or in the middle of a conversation. They last from a few seconds to a few minutes and often lead to a longer nap, after which affected individuals wake up feeling refreshed.\n\nNarcolepsy is a chronic sleep disorder that disrupts the normal sleep-wake cycle. Although this condition can appear at any age, it most often begins in adolescence.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/481896">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_813625"><div><strong>Autosomal dominant cerebellar ataxia, deafness and narcolepsy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>813625</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3807295</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">ADCADN is an autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy/cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression (summary by Winkelmann et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/813625">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1798877"><div><strong>Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1798877</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5567454</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PEBAT is an autosomal recessive neurodevelopmental disorder characterized by severely delayed psychomotor development apparent soon after birth or in infancy, profound intellectual disability, poor or absent speech, and seizures. Most patients are never able to walk due to hypotonia or spasticity. Brain imaging shows cerebral and cerebellar atrophy, thin corpus callosum, and secondary hypomyelination. The disorder shows progressive features, including microcephaly, consistent with a neurodegenerative process (summary by Miyake et al., 2016; Flex et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1798877">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_813625" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant cerebellar ataxia, deafness and narcolepsy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1798877" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_371809" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Narcolepsy 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332320" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Narcolepsy 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481896" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Narcolepsy 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_465922" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Niemann-Pick disease, type C1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_335942" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Niemann-Pick disease, type C2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35426627">Common Sleep Disorders in Adults: Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Holder S,
|
||
Narula NS</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2022 Apr 1;105(4):397-405.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35426627" target="_blank">35426627</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34173288">European guideline and expert statements on the management of narcolepsy in adults and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti CLA,
|
||
Kallweit U,
|
||
Vignatelli L,
|
||
Plazzi G,
|
||
Lecendreux M,
|
||
Baldin E,
|
||
Dolenc-Groselj L,
|
||
Jennum P,
|
||
Khatami R,
|
||
Manconi M,
|
||
Mayer G,
|
||
Partinen M,
|
||
Pollmächer T,
|
||
Reading P,
|
||
Santamaria J,
|
||
Sonka K,
|
||
Dauvilliers Y,
|
||
Lammers GJ</span><br />
|
||
<span class="medgenPMjournal">J Sleep Res</span>
|
||
2021 Dec;30(6):e13387.
|
||
Epub 2021 Jun 25
|
||
doi: 10.1111/jsr.13387.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34173288" target="_blank">34173288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31324898">Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti CLA,
|
||
Adamantidis A,
|
||
Burdakov D,
|
||
Han F,
|
||
Gay S,
|
||
Kallweit U,
|
||
Khatami R,
|
||
Koning F,
|
||
Kornum BR,
|
||
Lammers GJ,
|
||
Liblau RS,
|
||
Luppi PH,
|
||
Mayer G,
|
||
Pollmächer T,
|
||
Sakurai T,
|
||
Sallusto F,
|
||
Scammell TE,
|
||
Tafti M,
|
||
Dauvilliers Y</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Neurol</span>
|
||
2019 Sep;15(9):519-539.
|
||
Epub 2019 Jul 19
|
||
doi: 10.1038/s41582-019-0226-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31324898" target="_blank">31324898</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22cataplexy%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (131)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37891001">Drop attacks: a practical guide.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Manford E,
|
||
Garg A,
|
||
Manford M</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2024 Mar 19;24(2):106-113.
|
||
doi: 10.1136/pn-2023-003791.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37891001" target="_blank">37891001</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34173288">European guideline and expert statements on the management of narcolepsy in adults and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti CLA,
|
||
Kallweit U,
|
||
Vignatelli L,
|
||
Plazzi G,
|
||
Lecendreux M,
|
||
Baldin E,
|
||
Dolenc-Groselj L,
|
||
Jennum P,
|
||
Khatami R,
|
||
Manconi M,
|
||
Mayer G,
|
||
Partinen M,
|
||
Pollmächer T,
|
||
Reading P,
|
||
Santamaria J,
|
||
Sonka K,
|
||
Dauvilliers Y,
|
||
Lammers GJ</span><br />
|
||
<span class="medgenPMjournal">J Sleep Res</span>
|
||
2021 Dec;30(6):e13387.
|
||
Epub 2021 Jun 25
|
||
doi: 10.1111/jsr.13387.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34173288" target="_blank">34173288</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28991006">Autoimmunity in narcolepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bonvalet M,
|
||
Ollila HM,
|
||
Ambati A,
|
||
Mignot E</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Pulm Med</span>
|
||
2017 Nov;23(6):522-529.
|
||
doi: 10.1097/MCP.0000000000000426.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28991006" target="_blank">28991006</a><a href="/pmc/articles/PMC5773260" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28179647">Narcolepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kornum BR,
|
||
Knudsen S,
|
||
Ollila HM,
|
||
Pizza F,
|
||
Jennum PJ,
|
||
Dauvilliers Y,
|
||
Overeem S</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2017 Feb 9;3:16100.
|
||
doi: 10.1038/nrdp.2016.100.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28179647" target="_blank">28179647</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21073334">Update on sleep and its disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pack AI,
|
||
Pien GW</span><br />
|
||
<span class="medgenPMjournal">Annu Rev Med</span>
|
||
2011;62:447-60.
|
||
doi: 10.1146/annurev-med-050409-104056.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21073334" target="_blank">21073334</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cataplexy%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (549)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37634997">Narcolepsies, update in 2023.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barateau L,
|
||
Pizza F,
|
||
Chenini S,
|
||
Peter-Derex L,
|
||
Dauvilliers Y</span><br />
|
||
<span class="medgenPMjournal">Rev Neurol (Paris)</span>
|
||
2023 Oct;179(7):727-740.
|
||
Epub 2023 Aug 25
|
||
doi: 10.1016/j.neurol.2023.08.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37634997" target="_blank">37634997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35819343">REM sleep, REM parasomnias, REM sleep behaviour disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szûcs A,
|
||
Mutti C,
|
||
Papp A,
|
||
Halász P,
|
||
Parrino L</span><br />
|
||
<span class="medgenPMjournal">Ideggyogy Sz</span>
|
||
2022 May 30;75(5-06):171-182.
|
||
doi: 10.18071/isz.75.0171.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35819343" target="_blank">35819343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35624073">Narcolepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barateau L,
|
||
Pizza F,
|
||
Plazzi G,
|
||
Dauvilliers Y</span><br />
|
||
<span class="medgenPMjournal">J Sleep Res</span>
|
||
2022 Aug;31(4):e13631.
|
||
Epub 2022 May 27
|
||
doi: 10.1111/jsr.13631.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35624073" target="_blank">35624073</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26716917">Narcolepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scammell TE</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2015 Dec 31;373(27):2654-62.
|
||
doi: 10.1056/NEJMra1500587.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26716917" target="_blank">26716917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8871976">Narcolepsy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti C,
|
||
Aldrich MS</span><br />
|
||
<span class="medgenPMjournal">Neurol Clin</span>
|
||
1996 Aug;14(3):545-71.
|
||
doi: 10.1016/s0733-8619(05)70273-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8871976" target="_blank">8871976</a></div>
|
||
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<div class="nl"><a target="_blank" href="/pubmed/39894590">The Past and Future of Sleep Medicine.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Vanier MT</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/4809449">Narcolepsy.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37494485">Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Dauvilliers Y,
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Scammell TE,
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<div class="nl"><a target="_blank" href="/pubmed/31004212">Update on narcolepsy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Reading PJ</span><br />
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Lammers GJ,
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Arnulf I,
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Mayer G,
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<div class="portlet_content ln"><span class="medgenPMauthor">Vanier MT</span><br />
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<span class="medgenPMjournal">Orphanet J Rare Dis</span>
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<div class="nl"><a target="_blank" href="/pubmed/18565458">CSF hypocretin-1 assessment in sleep and neurological disorders.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bourgin P,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cataplexy%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (413)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/34173695">European guideline and expert statements on the management of narcolepsy in adults and children.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti CLA,
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Kallweit U,
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Vignatelli L,
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Plazzi G,
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Lecendreux M,
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Baldin E,
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Dolenc-Groselj L,
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Jennum P,
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Khatami R,
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Manconi M,
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Mayer G,
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Partinen M,
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Pollmächer T,
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Reading P,
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Santamaria J,
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Sonka K,
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Dauvilliers Y,
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Lammers GJ</span><br />
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<span class="medgenPMjournal">Eur J Neurol</span>
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Epub 2021 Jun 25
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<span class="bold">PMID: </span><a href="/pubmed/34173695" target="_blank">34173695</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34173288">European guideline and expert statements on the management of narcolepsy in adults and children.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bassetti CLA,
|
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Kallweit U,
|
||
Vignatelli L,
|
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Plazzi G,
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Lecendreux M,
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Baldin E,
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Dolenc-Groselj L,
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Jennum P,
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Khatami R,
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Manconi M,
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Mayer G,
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Partinen M,
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Pollmächer T,
|
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Reading P,
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Santamaria J,
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Sonka K,
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Dauvilliers Y,
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Lammers GJ</span><br />
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<span class="medgenPMjournal">J Sleep Res</span>
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2021 Dec;30(6):e13387.
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Epub 2021 Jun 25
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<span class="bold">PMID: </span><a href="/pubmed/34173288" target="_blank">34173288</a></div>
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||
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<div class="nl"><a target="_blank" href="/pubmed/31937172">Pitolisant for treating patients with narcolepsy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Li S,
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Yang J</span><br />
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Epub 2020 Jan 23
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<span class="bold">PMID: </span><a href="/pubmed/31937172" target="_blank">31937172</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30672873">Health-Related Quality of Life in Patients With Narcolepsy: A Review of the Literature.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Raggi A,
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Plazzi G,
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<span class="medgenPMjournal">J Nerv Ment Dis</span>
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2019 Feb;207(2):84-99.
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<span class="bold">PMID: </span><a href="/pubmed/30672873" target="_blank">30672873</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29580887">Neuroimaging correlates of narcolepsy with cataplexy: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wada M,
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Mimura M,
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Noda Y,
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Takasu S,
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Plitman E,
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Honda M,
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Natsubori A,
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<span class="bold">PMID: </span><a href="/pubmed/29580887" target="_blank">29580887</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cataplexy%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div></div>
|
||
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|
||
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|
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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