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<meta name="keywords" content="C0007282, artery narrowing, carotid, artery narrowings, carotid, artery stenoses, carotid, artery stenosis, carotid, carotid artery narrowing, carotid artery narrowings, carotid artery stenoses, carotid artery stenosis, carotid stenoses, carotid stenosis, disease or syndrome, narrowing of carotid artery, narrowing, carotid artery, narrowings, carotid artery, stenoses, carotid, stenoses, carotid artery, stenosis, carotid, stenosis, carotid artery, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Narrowing of the carotid arteries." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=785
|
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ConceptID=C0007282
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Carotid artery stenosis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>785</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0007282</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Carotid stenosis</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Carotid artery stenosis (64586002); Carotid artery narrowing (64586002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100546">HP:0100546</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0001612" target="_blank">MONDO:0001612</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Narrowing of the carotid arteries. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Carotid artery stenosis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/2848" ref="tree=MeSH" title="MedGen record for Disorder of cardiovascular system">Disorder of cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/22621" ref="tree=MeSH" title="MedGen record for Vascular disorder">Vascular disorder</a></span><ul><li><span class="TLline"><a href="/medgen/13913" ref="tree=MeSH" title="MedGen record for Arterial occlusive disease">Arterial occlusive disease</a></span><ul><li><span class="matched_ds">Carotid artery stenosis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_325051"><div><strong>CARASIL syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325051</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838577</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">HTRA1 disorder is a phenotypic spectrum in which some individuals have few to no symptoms and others manifest with the more severe CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) phenotype. Those who have a heterozygous HTRA1 pathogenic variant may have mild neurologic findings (sometimes identified only on neuroimaging) or mild-to-moderate neurologic signs and symptoms of CARASIL. In this chapter, the term "classic CARASIL" refers to the more severe phenotype associated with biallelic pathogenic variants, and "HTRA1 cerebral small vessel disease" (HTRA1-CSVD) refers to the milder phenotype associated with a heterozygous HTRA1 pathogenic variant. Classic CARASIL is characterized by early-onset changes in the deep white matter of the brain observed on MRI, and associated neurologic findings. The most frequent initial symptom is gait disturbance from spasticity beginning between ages 20 and 40 years. Forty-four percent of affected individuals have stroke-like episodes before age 40 years. Mood changes (apathy and irritability), pseudobulbar palsy, and cognitive dysfunction begin between ages 20 and 50 years. The disease progresses slowly following the onset of neurologic symptoms. Scalp alopecia and acute mid- to lower-back pain (lumbago) before age 30 years are characteristic. The most frequent initial symptom in individuals with HTRA1-CSVD is slowly progressive gait disturbance after age 40 years, which may be followed by the development of mood changes and cognitive dysfunction. A majority of affected individuals have a stroke-like episode after age 40 years. Spondylosis and alopecia are seen in a minority of individuals with HTRA1-CSVD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325051">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338704"><div><strong>Aortic aneurysm, familial thoracic 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338704</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1851504</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial thoracic aortic aneurysm and aortic dissection in which the cause of the disease is a mutation in the MYH11 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338704">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355427"><div><strong>Grange syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355427</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865267</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Grange syndrome (GRNG) is a rare early-onset disease characterized by hypertension and multifocal stenoocclusive lesions of renal, cerebral, and abdominal arteries. Bone fragility, syndactyly, brachydactyly, congenital heart defects, and learning disabilities have been reported with variable expressivity and incomplete penetrance (summary by Rath et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355427">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_440869"><div><strong>Sitosterolemia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>440869</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2749759</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sitosterolemia is characterized by: Hypercholesterolemia (especially in children) which (1) shows an unexpected significant lowering of plasma cholesterol level in response to low-fat diet modification or to bile acid sequestrant therapy; or (2) does not respond to statin therapy; Tendon xanthomas or tuberous (i.e., planar) xanthomas that can occur in childhood and in unusual locations (heels, knees, elbows, and buttocks); Premature atherosclerosis, which can lead to angina, aortic valve involvement, myocardial infarction, and sudden death; Hemolytic anemia, abnormally shaped erythrocytes (stomatocytes), and large platelets (macrothrombocytopenia). On occasion, the abnormal hematologic findings may be the initial presentation or the only clinical feature of this disorder. Arthritis, arthralgias, and splenomegaly may sometimes be seen and one study has concluded that "idiopathic" liver disease could be undiagnosed sitosterolemia. The clinical spectrum of sitosterolemia is probably not fully appreciated due to underdiagnosis and the fact that the phenotype in infants is likely to be highly dependent on diet.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/440869">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1632001"><div><strong>Ehlers-Danlos syndrome, classic-like, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1632001</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693870</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ehlers-Danlos syndrome classic-like-2 (EDSCLL2) is characterized by severe joint and skin laxity, osteoporosis involving the hips and spine, osteoarthritis, soft redundant skin that can be acrogeria-like, delayed wound healing with abnormal atrophic scarring, and shoulder, hip, knee, and ankle dislocations. Variable features include gastrointestinal and genitourinary manifestations, such as bowel rupture, gut dysmotility, cryptorchidism, and hernias; vascular complications, such as mitral valve prolapse and aortic root dilation; and skeletal anomalies (Blackburn et al., 2018). For a discussion of genetic heterogeneity of classic-like Ehlers-Danlos syndrome, see 606408. For a discussion of the classification of EDS, see 130000.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1632001">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1851566"><div><strong>Moyamoya disease 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1851566</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882748</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Moyamoya disease-7 (MYMY7) is a cerebrovascular disease that leads to strokes and neurologic deficits. The age at symptom onset is highly variable, ranging from childhood to adulthood. Brain imaging shows progressive occlusion and stenosis of the distal internal carotid arteries with collateral vessel formation. Intracranial aneurysms and involvement of the posterior circulation, including the basilar artery, may also be observed (Pinard et al., 2023). For a discussion of genetic heterogeneity of moyamoya disease, see MYMY1 (252350).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1851566">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortic aneurysm, familial thoracic 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325051" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CARASIL syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1632001" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ehlers-Danlos syndrome, classic-like, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355427" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Grange syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1851566" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Moyamoya disease 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_440869" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sitosterolemia 1</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35182512">Management of atherosclerotic extracranial carotid artery stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bonati LH,
|
||
Jansen O,
|
||
de Borst GJ,
|
||
Brown MM</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Mar;21(3):273-283.
|
||
doi: 10.1016/S1474-4422(21)00359-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35182512" target="_blank">35182512</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34153348">Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AbuRahma AF,
|
||
Avgerinos ED,
|
||
Chang RW,
|
||
Darling RC 3rd,
|
||
Duncan AA,
|
||
Forbes TL,
|
||
Malas MB,
|
||
Murad MH,
|
||
Perler BA,
|
||
Powell RJ,
|
||
Rockman CB,
|
||
Zhou W</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2022 Jan;75(1S):4S-22S.
|
||
Epub 2021 Jun 19
|
||
doi: 10.1016/j.jvs.2021.04.073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34153348" target="_blank">34153348</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34713283">Carotid artery stenosis: An approach to its diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arasu R,
|
||
Arasu A,
|
||
Muller J</span><br />
|
||
<span class="medgenPMjournal">Aust J Gen Pract</span>
|
||
2021 Nov;50(11):821-825.
|
||
doi: 10.31128/AJGP-10-20-5664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34713283" target="_blank">34713283</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22carotid%20artery%20stenosis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (292)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35107680">Carotid Endarterectomy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hara T,
|
||
Rai Y</span><br />
|
||
<span class="medgenPMjournal">Adv Tech Stand Neurosurg</span>
|
||
2022;44:187-207.
|
||
doi: 10.1007/978-3-030-87649-4_10.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35107680" target="_blank">35107680</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34713283">Carotid artery stenosis: An approach to its diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arasu R,
|
||
Arasu A,
|
||
Muller J</span><br />
|
||
<span class="medgenPMjournal">Aust J Gen Pract</span>
|
||
2021 Nov;50(11):821-825.
|
||
doi: 10.31128/AJGP-10-20-5664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34713283" target="_blank">34713283</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33528538">Screening for Carotid Artery Stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jin J</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2021 Feb 2;325(5):500.
|
||
doi: 10.1001/jama.2021.0035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33528538" target="_blank">33528538</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26230478">Contemporary carotid imaging: from degree of stenosis to plaque vulnerability.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brinjikji W,
|
||
Huston J 3rd,
|
||
Rabinstein AA,
|
||
Kim GM,
|
||
Lerman A,
|
||
Lanzino G</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg</span>
|
||
2016 Jan;124(1):27-42.
|
||
Epub 2015 Jul 31
|
||
doi: 10.3171/2015.1.JNS142452.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26230478" target="_blank">26230478</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7723155">Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">JAMA</span>
|
||
1995 May 10;273(18):1421-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7723155" target="_blank">7723155</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3418)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34713283">Carotid artery stenosis: An approach to its diagnosis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arasu R,
|
||
Arasu A,
|
||
Muller J</span><br />
|
||
<span class="medgenPMjournal">Aust J Gen Pract</span>
|
||
2021 Nov;50(11):821-825.
|
||
doi: 10.31128/AJGP-10-20-5664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34713283" target="_blank">34713283</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33982997">Screening for Asymptomatic Carotid Artery Stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mills J,
|
||
Molchan S</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2021 May 15;103(10):623-624.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33982997" target="_blank">33982997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26230478">Contemporary carotid imaging: from degree of stenosis to plaque vulnerability.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brinjikji W,
|
||
Huston J 3rd,
|
||
Rabinstein AA,
|
||
Kim GM,
|
||
Lerman A,
|
||
Lanzino G</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg</span>
|
||
2016 Jan;124(1):27-42.
|
||
Epub 2015 Jul 31
|
||
doi: 10.3171/2015.1.JNS142452.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26230478" target="_blank">26230478</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25770343">Screening for carotid artery stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huynh TT,
|
||
Broadbent KC,
|
||
Jacob AD,
|
||
James S,
|
||
Erasmus JJ</span><br />
|
||
<span class="medgenPMjournal">Semin Roentgenol</span>
|
||
2015 Apr;50(2):127-38.
|
||
Epub 2014 Oct 23
|
||
doi: 10.1053/j.ro.2014.10.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25770343" target="_blank">25770343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7723155">Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">JAMA</span>
|
||
1995 May 10;273(18):1421-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7723155" target="_blank">7723155</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1984)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36115360">Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reiff T,
|
||
Eckstein HH,
|
||
Mansmann U,
|
||
Jansen O,
|
||
Fraedrich G,
|
||
Mudra H,
|
||
Böckler D,
|
||
Böhm M,
|
||
Debus ES,
|
||
Fiehler J,
|
||
Mathias K,
|
||
Ringelstein EB,
|
||
Schmidli J,
|
||
Stingele R,
|
||
Zahn R,
|
||
Zeller T,
|
||
Niesen WD,
|
||
Barlinn K,
|
||
Binder A,
|
||
Glahn J,
|
||
Hacke W,
|
||
Ringleb PA;
|
||
SPACE-2 Investigators</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2022 Oct;21(10):877-888.
|
||
doi: 10.1016/S1474-4422(22)00290-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36115360" target="_blank">36115360</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34153348">Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AbuRahma AF,
|
||
Avgerinos ED,
|
||
Chang RW,
|
||
Darling RC 3rd,
|
||
Duncan AA,
|
||
Forbes TL,
|
||
Malas MB,
|
||
Murad MH,
|
||
Perler BA,
|
||
Powell RJ,
|
||
Rockman CB,
|
||
Zhou W</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2022 Jan;75(1S):4S-22S.
|
||
Epub 2021 Jun 19
|
||
doi: 10.1016/j.jvs.2021.04.073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34153348" target="_blank">34153348</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32096559">Carotid artery stenting versus endarterectomy for treatment of carotid artery stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Müller MD,
|
||
Lyrer P,
|
||
Brown MM,
|
||
Bonati LH</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Feb 25;2(2):CD000515.
|
||
doi: 10.1002/14651858.CD000515.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32096559" target="_blank">32096559</a><a href="/pmc/articles/PMC7041119" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12015848">Carotid endarterectomy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bailes JE</span><br />
|
||
<span class="medgenPMjournal">Neurosurgery</span>
|
||
2002 Jun;50(6):1290-5.
|
||
doi: 10.1097/00006123-200206000-00021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12015848" target="_blank">12015848</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7723155">Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">JAMA</span>
|
||
1995 May 10;273(18):1421-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7723155" target="_blank">7723155</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1889)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35608581">Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang RW,
|
||
Tucker LY,
|
||
Rothenberg KA,
|
||
Lancaster E,
|
||
Faruqi RM,
|
||
Kuang HC,
|
||
Flint AC,
|
||
Avins AL,
|
||
Nguyen-Huynh MN</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2022 May 24;327(20):1974-1982.
|
||
doi: 10.1001/jama.2022.4835.
|
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<span class="bold">PMID: </span><a href="/pubmed/35608581" target="_blank">35608581</a><a href="/pmc/articles/PMC9131743" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McArdle MJ,
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<div class="nl"><a target="_blank" href="/pubmed/20505173">Stenting versus endarterectomy for treatment of carotid-artery stenosis.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/17068431">Primary stroke prevention.</a></div>
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2006 Nov;106(11):40-1, 43-5, 48-9; quiz 49-50.
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<div class="nl"><a target="_blank" href="/pubmed/7723155">Endarterectomy for asymptomatic carotid artery stenosis. Executive Committee for the Asymptomatic Carotid Atherosclerosis Study.</a></div>
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<div class="portlet_content ln"><span class="medgenPMjournal">JAMA</span>
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<span class="bold">PMID: </span><a href="/pubmed/7723155" target="_blank">7723155</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1638)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/34818171">Do carotid artery calcifications seen on radiographs predict stenosis in asymptomatic adults?</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cowdrey D,
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Hahn TW,
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<div class="nl"><a target="_blank" href="/pubmed/34599416">Stroke Prevention with Extracranial Carotid Artery Disease.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun J,
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Yuan C,
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Hatsukami TS</span><br />
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<span class="medgenPMjournal">Curr Cardiol Rep</span>
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2021 Oct 1;23(11):161.
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doi: 10.1007/s11886-021-01593-1.
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<span class="bold">PMID: </span><a href="/pubmed/34599416" target="_blank">34599416</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31046628">The association between platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and carotid artery stenosis and stroke following carotid endarterectomy.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Deşer SB,
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Yucel SM,
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Demirag MK,
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Guclu MM,
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Kolbakir F,
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Keceligil HT</span><br />
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<span class="medgenPMjournal">Vascular</span>
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2019 Dec;27(6):604-611.
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Epub 2019 May 2
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doi: 10.1177/1708538119847390.
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<span class="bold">PMID: </span><a href="/pubmed/31046628" target="_blank">31046628</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30012816">Prediction Models for Clinical Outcome After a Carotid Revascularization Procedure.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Volkers EJ,
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Algra A,
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Kappelle LJ,
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Jansen O,
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Howard G,
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Hendrikse J,
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Halliday A,
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Gregson J,
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Fraedrich G,
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Eckstein HH,
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Calvet D,
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Bulbulia R,
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Brown MM,
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Becquemin JP,
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Ringleb PA,
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Mas JL,
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Bonati LH,
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Brott TG,
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Greving JP;
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Carotid Stenosis Trialists’ Collaboration</span><br />
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2018 Aug;49(8):1880-1885.
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doi: 10.1161/STROKEAHA.117.020486.
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||
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<div class="nl"><a target="_blank" href="/pubmed/24356054">Guidelines on the diagnosis and treatment of extracranial carotid artery stenosis from the Italian Society for Vascular and Endovascular Surgery.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Setacci C,
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Argenteri A,
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Cremonesi A,
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de Donato G,
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Galzerano G,
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Lanza G,
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Pulli R,
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Ricci S,
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Sbarigia E,
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Setacci F,
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Sirignano P,
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Peinetti F,
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Speziale F;
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Italian Society for Vascular and Endovascular Surgery</span><br />
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<span class="medgenPMjournal">J Cardiovasc Surg (Torino)</span>
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2014 Feb;55(1):119-31.
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||
<span class="bold">PMID: </span><a href="/pubmed/24356054" target="_blank">24356054</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1826)</a></div></div>
|
||
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37638399">Extracranial Carotid Plaque Calcification and Cerebrovascular Ischemia: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Homssi M,
|
||
Saha A,
|
||
Delgado D,
|
||
RoyChoudhury A,
|
||
Thomas C,
|
||
Lin M,
|
||
Baradaran H,
|
||
Kamel H,
|
||
Gupta A</span><br />
|
||
<span class="medgenPMjournal">Stroke</span>
|
||
2023 Oct;54(10):2621-2628.
|
||
Epub 2023 Aug 28
|
||
doi: 10.1161/STROKEAHA.123.042807.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37638399" target="_blank">37638399</a><a href="/pmc/articles/PMC10530110" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36682406">Optimal Management of Asymptomatic Carotid Artery Stenosis: A Systematic Review and Network Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gasior SA,
|
||
O'Donnell JPM,
|
||
Davey M,
|
||
Clarke J,
|
||
Jalali A,
|
||
Ryan É,
|
||
Aherne TM,
|
||
Walsh SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Vasc Endovasc Surg</span>
|
||
2023 May;65(5):690-699.
|
||
Epub 2023 Jan 20
|
||
doi: 10.1016/j.ejvs.2023.01.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36682406" target="_blank">36682406</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34153348">Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AbuRahma AF,
|
||
Avgerinos ED,
|
||
Chang RW,
|
||
Darling RC 3rd,
|
||
Duncan AA,
|
||
Forbes TL,
|
||
Malas MB,
|
||
Murad MH,
|
||
Perler BA,
|
||
Powell RJ,
|
||
Rockman CB,
|
||
Zhou W</span><br />
|
||
<span class="medgenPMjournal">J Vasc Surg</span>
|
||
2022 Jan;75(1S):4S-22S.
|
||
Epub 2021 Jun 19
|
||
doi: 10.1016/j.jvs.2021.04.073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34153348" target="_blank">34153348</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32096559">Carotid artery stenting versus endarterectomy for treatment of carotid artery stenosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Müller MD,
|
||
Lyrer P,
|
||
Brown MM,
|
||
Bonati LH</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Feb 25;2(2):CD000515.
|
||
doi: 10.1002/14651858.CD000515.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32096559" target="_blank">32096559</a><a href="/pmc/articles/PMC7041119" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12022939">The cost-effectiveness of magnetic resonance angiography for carotid artery stenosis and peripheral vascular disease: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berry E,
|
||
Kelly S,
|
||
Westwood ME,
|
||
Davies LM,
|
||
Gough MJ,
|
||
Bamford JM,
|
||
Meaney JF,
|
||
Airey CM,
|
||
Cullingworth J,
|
||
Barbieri M,
|
||
Jackson A,
|
||
Smith MA</span><br />
|
||
<span class="medgenPMjournal">Health Technol Assess</span>
|
||
2002;6(7):1-155.
|
||
doi: 10.3310/hta6070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12022939" target="_blank">12022939</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carotid%20artery%20stenosis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (120)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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