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<!--
|
||
UID=9725
|
||
ConceptID=C0023418
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Leukemia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9725</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023418</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Leucocythaemia; Leucocythaemias; Leucocythemia; Leucocythemias; Leukemias</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Leukemia (93143009); Leukemia, disease (93143009); Leukemia (1162768007)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001909">HP:0001909</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0005059" target="_blank">MONDO:0005059</a></td></tr>
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||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023418[DISCUI]&test_type=Clinical" ref="ncbi_uid=9725">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Leukemia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/138213" ref="tree=MeSH" title="MedGen record for Hematologic neoplasm">Hematologic neoplasm</a></span><ul><li><span class="matched_ds">Leukemia</span><ul><li><span class="TLline"><a href="/medgen/43225" ref="tree=MeSH" title="MedGen record for Acute leukemia">Acute leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/7318" ref="tree=MeSH" title="MedGen record for Acute biphenotypic leukemia">Acute biphenotypic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/926425" ref="tree=MeSH" title="MedGen record for Infant Acute Biphenotypic Leukemia">Infant Acute Biphenotypic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1641256" ref="tree=MeSH" title="MedGen record for Recurrent Acute Biphenotypic Leukemia">Recurrent Acute Biphenotypic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1731320" ref="tree=MeSH" title="MedGen record for Refractory Acute Biphenotypic Leukemia">Refractory Acute Biphenotypic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/226983" ref="tree=MeSH" title="MedGen record for Acute leukemia of ambiguous lineage">Acute leukemia of ambiguous lineage</a></span><ul><li><span class="TLline"><a href="/medgen/1666838" ref="tree=MeSH" title="MedGen record for Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified">Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/79081" ref="tree=MeSH" title="MedGen record for Acute undifferentiated leukemia">Acute undifferentiated leukemia</a></span></li><li><span class="TLline"><a href="/medgen/417342" ref="tree=MeSH" title="MedGen record for Mixed phenotype acute leukemia">Mixed phenotype acute leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1747716" ref="tree=MeSH" title="MedGen record for Recurrent Acute Leukemia of Ambiguous Lineage">Recurrent Acute Leukemia of Ambiguous Lineage</a></span></li><li><span class="TLline"><a href="/medgen/1751423" ref="tree=MeSH" title="MedGen record for Refractory Acute Leukemia of Ambiguous Lineage">Refractory Acute Leukemia of Ambiguous Lineage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7317" ref="tree=MeSH" title="MedGen record for Acute lymphoid leukemia">Acute lymphoid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/890737" ref="tree=MeSH" title="MedGen record for Acute Lymphoblastic Leukemia by Gene Expression Profile">Acute Lymphoblastic Leukemia by Gene Expression Profile</a></span></li><li><span class="TLline"><a href="/medgen/199693" ref="tree=MeSH" title="MedGen record for Adult acute lymphoblastic leukemia">Adult acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/231365" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia">Aleukemic Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/226949" ref="tree=MeSH" title="MedGen record for B-cell acute lymphoblastic leukemia">B-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44122" ref="tree=MeSH" title="MedGen record for Childhood acute lymphoblastic leukemia">Childhood acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/313581" ref="tree=MeSH" title="MedGen record for Ph-positive acute lymphoblastic leukemia">Ph-positive acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/83896" ref="tree=MeSH" title="MedGen record for Precursor B-cell acute lymphoblastic leukemia">Precursor B-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/976286" ref="tree=MeSH" title="MedGen record for Precursor T-cell acute lymphoblastic leukemia">Precursor T-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1632670" ref="tree=MeSH" title="MedGen record for Recurrent Acute Lymphoblastic Leukemia">Recurrent Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1612918" ref="tree=MeSH" title="MedGen record for Refractory Acute Lymphoblastic Leukemia">Refractory Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/368378" ref="tree=MeSH" title="MedGen record for T-cell acute lymphoblastic leukemia">T-cell acute lymphoblastic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44124" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia">Acute megakaryoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/79016" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in adult">Acute megakaryoblastic leukemia in adult</a></span></li><li><span class="TLline"><a href="/medgen/1863778" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia in down syndrome">Acute megakaryoblastic leukemia in down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1843134" ref="tree=MeSH" title="MedGen record for Acute megakaryoblastic leukemia without down syndrome">Acute megakaryoblastic leukemia without down syndrome</a></span></li><li><span class="TLline"><a href="/medgen/79023" ref="tree=MeSH" title="MedGen record for Childhood acute megakaryoblastic leukemia">Childhood acute megakaryoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1718677" ref="tree=MeSH" title="MedGen record for Recurrent Acute Megakaryoblastic Leukemia">Recurrent Acute Megakaryoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7319" ref="tree=MeSH" title="MedGen record for Acute monocytic leukemia">Acute monocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/9730" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia">Acute myeloid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/7314" ref="tree=MeSH" title="MedGen record for Acute basophilic leukemia">Acute basophilic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44121" ref="tree=MeSH" title="MedGen record for Acute Eosinophilic Leukemia">Acute Eosinophilic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/824521" ref="tree=MeSH" title="MedGen record for Acute Monoblastic and Monocytic Leukemia">Acute Monoblastic and Monocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/361829" ref="tree=MeSH" title="MedGen record for Acute myeloblastic leukemia with maturation">Acute myeloblastic leukemia with maturation</a></span></li><li><span class="TLline"><a href="/medgen/10232" ref="tree=MeSH" title="MedGen record for Acute myeloblastic leukemia without maturation">Acute myeloblastic leukemia without maturation</a></span></li><li><span class="TLline"><a href="/medgen/101100" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with minimal differentiation">Acute myeloid leukemia with minimal differentiation</a></span></li><li><span class="TLline"><a href="/medgen/224861" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with multilineage dysplasia">Acute myeloid leukemia with multilineage dysplasia</a></span></li><li><span class="TLline"><a href="/medgen/220899" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia with recurrent genetic anomaly">Acute myeloid leukemia with recurrent genetic anomaly</a></span></li><li><span class="TLline"><a href="/medgen/7316" ref="tree=MeSH" title="MedGen record for Acute myeloid leukemia, M6 type">Acute myeloid leukemia, M6 type</a></span></li><li><span class="TLline"><a href="/medgen/414578" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia, Myelodysplasia-Related">Acute Myeloid Leukemia, Myelodysplasia-Related</a></span></li><li><span class="TLline"><a href="/medgen/9732" ref="tree=MeSH" title="MedGen record for Acute myelomonocytic leukemia M4">Acute myelomonocytic leukemia M4</a></span></li><li><span class="TLline"><a href="/medgen/87279" ref="tree=MeSH" title="MedGen record for Acute panmyelosis with myelofibrosis">Acute panmyelosis with myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/44127" ref="tree=MeSH" title="MedGen record for Acute promyelocytic leukemia">Acute promyelocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/113092" ref="tree=MeSH" title="MedGen record for Adult Acute Myeloid Leukemia">Adult Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/65075" ref="tree=MeSH" title="MedGen record for Childhood acute myeloid leukemia">Childhood acute myeloid leukemia</a></span></li><li><span class="TLline"><a href="/medgen/889446" ref="tree=MeSH" title="MedGen record for Childhood Acute Myeloid Leukemia Not Otherwise Specified">Childhood Acute Myeloid Leukemia Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/825713" ref="tree=MeSH" title="MedGen record for Cytogenetically Normal Acute Myeloid Leukemia">Cytogenetically Normal Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1634915" ref="tree=MeSH" title="MedGen record for Inherited acute myeloid leukemia">Inherited acute myeloid leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44123" ref="tree=MeSH" title="MedGen record for Mast cell leukemia">Mast cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1661148" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia">Recurrent Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1656787" ref="tree=MeSH" title="MedGen record for Recurrent Acute Myeloid Leukemia Not Otherwise Specified">Recurrent Acute Myeloid Leukemia Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/1627534" ref="tree=MeSH" title="MedGen record for Refractory Acute Myeloid Leukemia">Refractory Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1773485" ref="tree=MeSH" title="MedGen record for Refractory Acute Myeloid Leukemia Not Otherwise Specified">Refractory Acute Myeloid Leukemia Not Otherwise Specified</a></span></li><li><span class="TLline"><a href="/medgen/76113" ref="tree=MeSH" title="MedGen record for Secondary Acute Myeloid Leukemia">Secondary Acute Myeloid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1658558" ref="tree=MeSH" title="MedGen record for Burkitt Leukemia">Burkitt Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/75998" ref="tree=MeSH" title="MedGen record for Adult Burkitt Leukemia">Adult Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/83525" ref="tree=MeSH" title="MedGen record for Childhood Burkitt Leukemia">Childhood Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1670551" ref="tree=MeSH" title="MedGen record for Recurrent Burkitt Leukemia">Recurrent Burkitt Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1650262" ref="tree=MeSH" title="MedGen record for Refractory Burkitt Leukemia">Refractory Burkitt Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1668204" ref="tree=MeSH" title="MedGen record for Recurrent Acute Leukemia">Recurrent Acute Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1662593" ref="tree=MeSH" title="MedGen record for Refractory Acute Leukemia">Refractory Acute Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/164094" ref="tree=MeSH" title="MedGen record for Aleukemic leukemia">Aleukemic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/168394" ref="tree=MeSH" title="MedGen record for Aleukemic leukemia cutis">Aleukemic leukemia cutis</a></span><ul><li><span class="TLline"><a href="/medgen/231366" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia Cutis">Aleukemic Acute Lymphoblastic Leukemia Cutis</a></span></li><li><span class="TLline"><a href="/medgen/231050" ref="tree=MeSH" title="MedGen record for Aleukemic monocytic leukemia cutis">Aleukemic monocytic leukemia cutis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83179" ref="tree=MeSH" title="MedGen record for Aleukemic Lymphoid Leukemia">Aleukemic Lymphoid Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/482968" ref="tree=MeSH" title="MedGen record for Aleukemic Chronic Lymphocytic Leukemia">Aleukemic Chronic Lymphocytic Leukemia</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/88344" ref="tree=MeSH" title="MedGen record for Bovine Leukoses, Enzootic">Bovine Leukoses, Enzootic</a></span></li><li><span class="TLline"><a href="/medgen/234102" ref="tree=MeSH" title="MedGen record for Central nervous system leukemia">Central nervous system leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/452807" ref="tree=MeSH" title="MedGen record for Meningeal Leukemia">Meningeal Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/78930" ref="tree=MeSH" title="MedGen record for Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive">Meningeal Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/234132" ref="tree=MeSH" title="MedGen record for Childhood leukemia">Childhood leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/233004" ref="tree=MeSH" title="MedGen record for Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive">Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li><li><span class="TLline"><a href="/medgen/885468" ref="tree=MeSH" title="MedGen record for Infant Leukemia">Infant Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/888328" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6">Acute Myeloid Leukemia with t(7;12)(q36;p13); HLXB9-ETV6</a></span></li><li><span class="TLline"><a href="/medgen/889772" ref="tree=MeSH" title="MedGen record for Infant Acute Lymphoblastic Leukemia">Infant Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/926424" ref="tree=MeSH" title="MedGen record for Infant Acute Undifferentiated Leukemia">Infant Acute Undifferentiated Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/116003" ref="tree=MeSH" title="MedGen record for Neonatal leukemia">Neonatal leukemia</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/220905" ref="tree=MeSH" title="MedGen record for Chronic leukemia">Chronic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/266235" ref="tree=MeSH" title="MedGen record for Aggressive NK-cell leukemia">Aggressive NK-cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1680914" ref="tree=MeSH" title="MedGen record for Recurrent Aggressive NK-Cell Leukemia">Recurrent Aggressive NK-Cell Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1676365" ref="tree=MeSH" title="MedGen record for Refractory Aggressive NK-Cell Leukemia">Refractory Aggressive NK-Cell Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44120" ref="tree=MeSH" title="MedGen record for B-cell chronic lymphocytic leukemia">B-cell chronic lymphocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/232077" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation">Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation</a></span></li><li><span class="TLline"><a href="/medgen/272481" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation">Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation</a></span></li><li><span class="TLline"><a href="/medgen/234147" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene">Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene</a></span></li><li><span class="TLline"><a href="/medgen/1647247" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia- Binet Staging System">Chronic Lymphocytic Leukemia- Binet Staging System</a></span></li><li><span class="TLline"><a href="/medgen/1647279" ref="tree=MeSH" title="MedGen record for Chronic Lymphocytic Leukemia- Modified Rai Staging System">Chronic Lymphocytic Leukemia- Modified Rai Staging System</a></span></li><li><span class="TLline"><a href="/medgen/310644" ref="tree=MeSH" title="MedGen record for Cutaneous Chronic Lymphocytic Leukemia">Cutaneous Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/167714" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Lymphocytic Leukemia">Recurrent Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/124512" ref="tree=MeSH" title="MedGen record for Refractory Chronic Lymphocytic Leukemia">Refractory Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234810" ref="tree=MeSH" title="MedGen record for Splenic Manifestation of Chronic Lymphocytic Leukemia">Splenic Manifestation of Chronic Lymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1678720" ref="tree=MeSH" title="MedGen record for Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma">Transformed Chronic Lymphocytic Leukemia to Diffuse Large B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/91106" ref="tree=MeSH" title="MedGen record for Chronic eosinophilic leukemia">Chronic eosinophilic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/927323" ref="tree=MeSH" title="MedGen record for Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA">Chronic Eosinophilic Leukemia with FIP1L1-PDGFRA</a></span></li><li><span class="TLline"><a href="/medgen/75993" ref="tree=MeSH" title="MedGen record for Chronic myelogenous leukemia, BCR-ABL1 positive">Chronic myelogenous leukemia, BCR-ABL1 positive</a></span><ul><li><span class="TLline"><a href="/medgen/2281" ref="tree=MeSH" title="MedGen record for Blast phase chronic myelogenous leukemia, BCR-ABL1 positive">Blast phase chronic myelogenous leukemia, BCR-ABL1 positive</a></span></li><li><span class="TLline"><a href="/medgen/6060" ref="tree=MeSH" title="MedGen record for Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive">Chronic Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li><li><span class="TLline"><a href="/medgen/6059" ref="tree=MeSH" title="MedGen record for Leukemia, myeloid, accelerated-phase">Leukemia, myeloid, accelerated-phase</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6061" ref="tree=MeSH" title="MedGen record for Chronic neutrophilic leukemia">Chronic neutrophilic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/9727" ref="tree=MeSH" title="MedGen record for Hairy cell leukemia">Hairy cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/83554" ref="tree=MeSH" title="MedGen record for Progressive Hairy Cell Leukemia Initial Treatment">Progressive Hairy Cell Leukemia Initial Treatment</a></span></li><li><span class="TLline"><a href="/medgen/124657" ref="tree=MeSH" title="MedGen record for Recurrent Hairy Cell Leukemia">Recurrent Hairy Cell Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1639342" ref="tree=MeSH" title="MedGen record for Refractory hairy cell leukemia">Refractory hairy cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234812" ref="tree=MeSH" title="MedGen record for Splenic manifestation of hairy cell leukemia">Splenic manifestation of hairy cell leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/91160" ref="tree=MeSH" title="MedGen record for Hairy cell leukemia variant">Hairy cell leukemia variant</a></span><ul><li><span class="TLline"><a href="/medgen/1746235" ref="tree=MeSH" title="MedGen record for Recurrent Hairy Cell Leukemia Variant">Recurrent Hairy Cell Leukemia Variant</a></span></li><li><span class="TLline"><a href="/medgen/1761125" ref="tree=MeSH" title="MedGen record for Refractory Hairy Cell Leukemia Variant">Refractory Hairy Cell Leukemia Variant</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6062" ref="tree=MeSH" title="MedGen record for Prolymphocytic leukemia">Prolymphocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/105396" ref="tree=MeSH" title="MedGen record for B-cell prolymphocytic leukemia">B-cell prolymphocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/277663" ref="tree=MeSH" title="MedGen record for Splenic manifestation of prolymphocytic leukemia">Splenic manifestation of prolymphocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/391707" ref="tree=MeSH" title="MedGen record for T-cell prolymphocytic leukemia">T-cell prolymphocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1663873" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Leukemia">Recurrent Chronic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1674441" ref="tree=MeSH" title="MedGen record for Recurrent B-Cell Prolymphocytic Leukemia">Recurrent B-Cell Prolymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/124511" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive">Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li><li><span class="TLline"><a href="/medgen/1668528" ref="tree=MeSH" title="MedGen record for Recurrent Chronic Myelomonocytic Leukemia">Recurrent Chronic Myelomonocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1778271" ref="tree=MeSH" title="MedGen record for Recurrent Sezary Syndrome">Recurrent Sezary Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1793212" ref="tree=MeSH" title="MedGen record for Recurrent T-Cell Large Granular Lymphocyte Leukemia">Recurrent T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1668022" ref="tree=MeSH" title="MedGen record for Recurrent T-Cell Prolymphocytic Leukemia">Recurrent T-Cell Prolymphocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1653223" ref="tree=MeSH" title="MedGen record for Refractory Chronic Leukemia">Refractory Chronic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1676333" ref="tree=MeSH" title="MedGen record for Refractory B-Cell Prolymphocytic Leukemia">Refractory B-Cell Prolymphocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234587" ref="tree=MeSH" title="MedGen record for Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive">Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li><li><span class="TLline"><a href="/medgen/1660926" ref="tree=MeSH" title="MedGen record for Refractory Chronic Myelomonocytic Leukemia">Refractory Chronic Myelomonocytic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1788498" ref="tree=MeSH" title="MedGen record for Refractory Sezary Syndrome">Refractory Sezary Syndrome</a></span></li><li><span class="TLline"><a href="/medgen/1794066" ref="tree=MeSH" title="MedGen record for Refractory T-Cell Large Granular Lymphocyte Leukemia">Refractory T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1672901" ref="tree=MeSH" title="MedGen record for Refractory T-Cell Prolymphocytic Leukemia">Refractory T-Cell Prolymphocytic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/363038" ref="tree=MeSH" title="MedGen record for T-cell large granular lymphocyte leukemia">T-cell large granular lymphocyte leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/236842" ref="tree=MeSH" title="MedGen record for Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia">Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/272804" ref="tree=MeSH" title="MedGen record for T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta">T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta</a></span></li><li><span class="TLline"><a href="/medgen/271549" ref="tree=MeSH" title="MedGen record for T-Cell Large Granular Lymphocyte Leukemia, Common Variant">T-Cell Large Granular Lymphocyte Leukemia, Common Variant</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/38985" ref="tree=MeSH" title="MedGen record for Feline Leukemias">Feline Leukemias</a></span></li><li><span class="TLline"><a href="/medgen/452808" ref="tree=MeSH" title="MedGen record for Leukemia Cutis">Leukemia Cutis</a></span></li><li><span class="TLline"><a href="/medgen/9728" ref="tree=MeSH" title="MedGen record for Lymphoid leukemia">Lymphoid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/412152" ref="tree=MeSH" title="MedGen record for B-Cell Leukemia">B-Cell Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/163423" ref="tree=MeSH" title="MedGen record for Leukemic Phase of Lymphoma">Leukemic Phase of Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/231024" ref="tree=MeSH" title="MedGen record for Acute Adult T-Cell Leukemia/Lymphoma">Acute Adult T-Cell Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/272480" ref="tree=MeSH" title="MedGen record for Chronic Adult T-Cell Leukemia/Lymphoma">Chronic Adult T-Cell Leukemia/Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1613227" ref="tree=MeSH" title="MedGen record for Leukemic Nonnodal Mantle Cell Lymphoma">Leukemic Nonnodal Mantle Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/19959" ref="tree=MeSH" title="MedGen record for Sezary syndrome">Sezary syndrome</a></span></li><li><span class="TLline"><a href="/medgen/234795" ref="tree=MeSH" title="MedGen record for Smoldering Adult T-Cell Leukemia/Lymphoma">Smoldering Adult T-Cell Leukemia/Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9733" ref="tree=MeSH" title="MedGen record for Plasma cell leukemia">Plasma cell leukemia</a></span></li><li><span class="TLline"><a href="/medgen/409528" ref="tree=MeSH" title="MedGen record for Precursor Cell Lymphoblastic Leukemia-Lymphoma">Precursor Cell Lymphoblastic Leukemia-Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/44126" ref="tree=MeSH" title="MedGen record for Pre-B Acute Lymphoblastic Leukemia">Pre-B Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/870727" ref="tree=MeSH" title="MedGen record for T cell chronic lymphocytic lymphoma/leukemia">T cell chronic lymphocytic lymphoma/leukemia</a></span></li><li><span class="TLline"><a href="/medgen/6064" ref="tree=MeSH" title="MedGen record for T-cell leukemia">T-cell leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/279467" ref="tree=MeSH" title="MedGen record for Large granular lymphocyte leukemia">Large granular lymphocyte leukemia</a></span></li><li><span class="TLline"><a href="/medgen/44128" ref="tree=MeSH" title="MedGen record for Leukemia-Lymphoma, Adult T-Cell">Leukemia-Lymphoma, Adult T-Cell</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/7320" ref="tree=MeSH" title="MedGen record for Myeloid leukemia">Myeloid leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/266233" ref="tree=MeSH" title="MedGen record for Atypical chronic myeloid leukemia, BCR-ABL1 negative">Atypical chronic myeloid leukemia, BCR-ABL1 negative</a></span><ul><li><span class="TLline"><a href="/medgen/79004" ref="tree=MeSH" title="MedGen record for Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive">Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/714993" ref="tree=MeSH" title="MedGen record for Chronic Myeloid Leukemia, BCR-ABL1 Positive">Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span><ul><li><span class="TLline"><a href="/medgen/234811" ref="tree=MeSH" title="MedGen record for Splenic Manifestation of Chronic Myeloid Leukemia, BCR-ABL1 Positive">Splenic Manifestation of Chronic Myeloid Leukemia, BCR-ABL1 Positive</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44125" ref="tree=MeSH" title="MedGen record for Chronic myelomonocytic leukemia">Chronic myelomonocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/232364" ref="tree=MeSH" title="MedGen record for Chronic Myelomonocytic Leukemia with Eosinophilia">Chronic Myelomonocytic Leukemia with Eosinophilia</a></span></li><li><span class="TLline"><a href="/medgen/1376419" ref="tree=MeSH" title="MedGen record for Chronic Myelomonocytic Leukemia-0">Chronic Myelomonocytic Leukemia-0</a></span></li><li><span class="TLline"><a href="/medgen/234148" ref="tree=MeSH" title="MedGen record for Chronic Myelomonocytic Leukemia-1">Chronic Myelomonocytic Leukemia-1</a></span></li><li><span class="TLline"><a href="/medgen/232363" ref="tree=MeSH" title="MedGen record for Chronic Myelomonocytic Leukemia-2">Chronic Myelomonocytic Leukemia-2</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/138109" ref="tree=MeSH" title="MedGen record for Juvenile myelomonocytic leukemia">Juvenile myelomonocytic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1656669" ref="tree=MeSH" title="MedGen record for Myeloid sarcoma">Myeloid sarcoma</a></span><ul><li><span class="TLline"><a href="/medgen/232590" ref="tree=MeSH" title="MedGen record for Cardiac Myeloid Sarcoma">Cardiac Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/56275" ref="tree=MeSH" title="MedGen record for Granulocytic sarcoma">Granulocytic sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/272769" ref="tree=MeSH" title="MedGen record for Intracranial Myeloid Sarcoma">Intracranial Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/313418" ref="tree=MeSH" title="MedGen record for Mediastinal Myeloid Sarcoma">Mediastinal Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/233716" ref="tree=MeSH" title="MedGen record for Monoblastic Sarcoma">Monoblastic Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1724518" ref="tree=MeSH" title="MedGen record for Oral Cavity Myeloid Sarcoma">Oral Cavity Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/235501" ref="tree=MeSH" title="MedGen record for Prostate Myeloid Sarcoma">Prostate Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1389378" ref="tree=MeSH" title="MedGen record for Small Intestinal Myeloid Sarcoma">Small Intestinal Myeloid Sarcoma</a></span></li><li><span class="TLline"><a href="/medgen/1692501" ref="tree=MeSH" title="MedGen record for Testicular Myeloid Sarcoma">Testicular Myeloid Sarcoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/9731" ref="tree=MeSH" title="MedGen record for Philadelphia-positive myelogenous leukemia">Philadelphia-positive myelogenous leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/10147" ref="tree=MeSH" title="MedGen record for Myeloproliferative disorder">Myeloproliferative disorder</a></span><ul><li><span class="TLline"><a href="/medgen/45996" ref="tree=MeSH" title="MedGen record for Acquired polycythemia vera">Acquired polycythemia vera</a></span><ul><li><span class="TLline"><a href="/medgen/271322" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Polycythemic Phase">Polycythemia Vera, Polycythemic Phase</a></span></li><li><span class="TLline"><a href="/medgen/1641083" ref="tree=MeSH" title="MedGen record for Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase">Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44129" ref="tree=MeSH" title="MedGen record for Leukemoid reaction">Leukemoid reaction</a></span><ul><li><span class="TLline"><a href="/medgen/760708" ref="tree=MeSH" title="MedGen record for Leukemoid reaction of the newborn">Leukemoid reaction of the newborn</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1529" ref="tree=MeSH" title="MedGen record for Myelophthisic anemia">Myelophthisic anemia</a></span></li><li><span class="TLline"><a href="/medgen/7929" ref="tree=MeSH" title="MedGen record for Primary myelofibrosis">Primary myelofibrosis</a></span><ul><li><span class="TLline"><a href="/medgen/275741" ref="tree=MeSH" title="MedGen record for Cellular phase chronic idiopathic myelofibrosis">Cellular phase chronic idiopathic myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/308982" ref="tree=MeSH" title="MedGen record for Overt Primary Myelofibrosis">Overt Primary Myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/1791967" ref="tree=MeSH" title="MedGen record for Recurrent Primary Myelofibrosis">Recurrent Primary Myelofibrosis</a></span></li><li><span class="TLline"><a href="/medgen/1740721" ref="tree=MeSH" title="MedGen record for Refractory Primary Myelofibrosis">Refractory Primary Myelofibrosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163397" ref="tree=MeSH" title="MedGen record for Thrombocytosis">Thrombocytosis</a></span><ul><li><span class="TLline"><a href="/medgen/11797" ref="tree=MeSH" title="MedGen record for Essential thrombocythemia">Essential thrombocythemia</a></span></li><li><span class="TLline"><a href="/medgen/929430" ref="tree=MeSH" title="MedGen record for Familial thrombocytosis">Familial thrombocytosis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/331782" ref="tree=MeSH" title="MedGen record for Transient myeloproliferative syndrome">Transient myeloproliferative syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/6063" ref="tree=MeSH" title="MedGen record for Radiation-Related Leukemia">Radiation-Related Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1652854" ref="tree=MeSH" title="MedGen record for Recurrent Leukemia">Recurrent Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1655716" ref="tree=MeSH" title="MedGen record for Refractory Leukemia">Refractory Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234813" ref="tree=MeSH" title="MedGen record for Splenic manifestation of leukemia">Splenic manifestation of leukemia</a></span></li><li><span class="TLline"><a href="/medgen/234941" ref="tree=MeSH" title="MedGen record for Testicular leukemia">Testicular leukemia</a></span></li><li><span class="TLline"><a href="/medgen/414619" ref="tree=MeSH" title="MedGen record for Therapy-Related Leukemia">Therapy-Related Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/237008" ref="tree=MeSH" title="MedGen record for Acute Myeloid Leukemia Post Cytotoxic Therapy">Acute Myeloid Leukemia Post Cytotoxic Therapy</a></span><ul><li><span class="TLline"><a href="/medgen/730170" ref="tree=MeSH" title="MedGen record for Alkylating Agent-Related Acute Myeloid Leukemia">Alkylating Agent-Related Acute Myeloid Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/237013" ref="tree=MeSH" title="MedGen record for Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia">Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/163682" ref="tree=MeSH" title="MedGen record for Chemotherapy-Related Leukemia">Chemotherapy-Related Leukemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_439"><div><strong>Ataxia-telangiectasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>439</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0004135</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The phenotypic spectrum of ataxia-telangiectasia (A-T), a multisystem disorder, is a continuum ranging from classic A-T at the severe end and variant A-T at the milder end. Nonetheless, distinguishing between classic A-T and variant A-T on this spectrum helps understand differences in disease course, rate of progression, and life expectancy. Classic A-T is characterized by childhood onset of progressive neurologic manifestations (initially cerebellar ataxia, followed typically by extrapyramidal involvement and peripheral sensorimotor neuropathy), immunodeficiency (variably associated with abnormalities of humoral immunity, cellular immunity, or combined immune deficiency), pulmonary disease (resulting from recurrent infections, immune deficiency, aspiration, interstitial lung disease, and neurologic abnormalities), and increased risk of malignancy. Although it is generally accepted that intellectual disability is not common in A-T, disturbances in cerebellar as well as non-cerebellar brain areas and networks may result in cognitive deficits. Increased sensitivity to ionizing radiation (x-ray and gamma ray) can result in severe side effects from such treatments. Life expectancy is significantly reduced due to cancer, pulmonary disease, and infections. Variant A-T has a significantly milder disease course. While cerebellar ataxia can be absent, extrapyramidal movement disorders are common (typically dystonia and dystonic tremor) and most individuals have manifestations of axonal sensorimotor polyneuropathy. In contrast to classic A-T, immune function is generally normal, respiratory infections are not increased, and pulmonary disease is not a major feature. However, risk of developing malignancies is increased, particularly in premenopausal females who have an increased risk of developing breast cancer and hematologic malignancies.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/439">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_2685"><div><strong>Bloom syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2685</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0005859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Bloom syndrome (BSyn) is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. Despite their very small head circumference, most affected individuals have normal intellectual ability. Women may be fertile but often have early menopause, and men tend to be infertile, with only one confirmed case of paternity. Serious medical complications that are more common than in the general population and that also appear at unusually early ages include cancer of a wide variety of types and anatomic sites, diabetes mellitus as a result of insulin resistance, chronic obstructive pulmonary disease, and hypothyroidism.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/2685">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_20552"><div><strong>Retinoblastoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>20552</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0035335</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is associated with susceptibility for retinoblastoma as well as non-ocular tumors.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/20552">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_320546"><div><strong>Macroglobulinemia, Waldenstrom, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>320546</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835192</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by the observation of familial clustering of WM (McMaster, 2003). Whereas WM is rare, an asymptomatic elevation of monoclonal IgM protein, termed 'IgM monoclonal gammopathy of undetermined significance' (IgM MGUS) is more common. Patients with IgM MGUS can progress to develop WM, at the rate of 1.5% to 2% per year (Kyle et al., 2003). Genetic Heterogeneity of Waldenstrom Macroglobulinemia A locus for susceptibility to Waldenstrom macroglobulinemia (WM2; 610430) has been mapped to chromosome 4q.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/320546">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_338026"><div><strong>Mosaic variegated aneuploidy syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338026</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850343</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Mosaic variegated aneuploidy (MVA) syndrome is a rare disorder in which some cells in the body have an abnormal number of chromosomes instead of the usual 46 chromosomes, a situation known as aneuploidy. Most commonly, cells have an extra chromosome, which is called trisomy, or are missing a chromosome, which is known as monosomy. In MVA syndrome, some cells are aneuploid and others have the normal number of chromosomes, which is a phenomenon known as mosaicism. Typically, at least one-quarter of cells in affected individuals have an abnormal number of chromosomes. Because the additional or missing chromosomes vary among the abnormal cells, the aneuploidy is described as variegated.\n\nThere are at least three types of MVA syndrome, each with a different genetic cause. Type 1 is the most common and displays the classic signs and symptoms described above. Type 2 appears to have slightly different signs and symptoms than type 1, although the small number of affected individuals makes it difficult to define its characteristic features. Individuals with MVA syndrome type 2 grow slowly before and after birth; however, their head size is typically normal. Some people with MVA syndrome type 2 have unusually short arms. Individuals with MVA syndrome type 2 do not seem to have an increased risk of cancer. Another form of MVA syndrome is characterized by a high risk of developing Wilms tumor. Individuals with this form may also have other signs and symptoms typical of MVA syndrome type 1.\n\nIn MVA syndrome, growth before birth is slow (intrauterine growth restriction). After birth, affected individuals continue to grow at a slow rate and are shorter than average. In addition, they typically have an unusually small head size (microcephaly). Another common feature of MVA syndrome is an increased risk of developing cancer in childhood. Cancers that occur most frequently in affected individuals include a cancer of muscle tissue called rhabdomyosarcoma, a form of kidney cancer known as Wilms tumor, and a cancer of the blood-forming tissue known as leukemia.\n\nLess commonly, people with MVA syndrome have eye abnormalities or distinctive facial features, such as a broad nasal bridge and low-set ears. Some affected individuals have brain abnormalities, the most common of which is called Dandy-Walker malformation. Intellectual disability, seizures, and other health problems can also occur in people with MVA syndrome.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/338026">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_344290"><div><strong>Noonan syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344290</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854469</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Noonan syndrome (NS) is characterized by characteristic facies, short stature, congenital heart defect, and developmental delay of variable degree. Other findings can include broad or webbed neck, unusual chest shape with superior pectus carinatum and inferior pectus excavatum, cryptorchidism, varied coagulation defects, lymphatic dysplasias, and ocular abnormalities. Although birth length is usually normal, final adult height approaches the lower limit of normal. Congenital heart disease occurs in 50%-80% of individuals. Pulmonary valve stenosis, often with dysplasia, is the most common heart defect and is found in 20%-50% of individuals. Hypertrophic cardiomyopathy, found in 20%-30% of individuals, may be present at birth or develop in infancy or childhood. Other structural defects include atrial and ventricular septal defects, branch pulmonary artery stenosis, and tetralogy of Fallot. Up to one fourth of affected individuals have mild intellectual disability, and language impairments in general are more common in NS than in the general population.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/344290">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_355421"><div><strong>Megalencephaly-capillary malformation-polymicrogyria syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355421</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1865285</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Prior to the identification of PIK3CA as the causative gene, PROS was separated into distinct clinical syndromes based on the tissues and/or organs involved (e.g., MCAP [megalencephaly-capillary malformation] syndrome and CLOVES [congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies] syndrome). The predominant areas of overgrowth include the brain, limbs (including fingers and toes), trunk (including abdomen and chest), and face, all usually in an asymmetric distribution. Generalized brain overgrowth may be accompanied by secondary overgrowth of specific brain structures resulting in ventriculomegaly, a markedly thick corpus callosum, and cerebellar tonsillar ectopia with crowding of the posterior fossa. Vascular malformations may include capillary, venous, and less frequently, arterial or mixed (capillary-lymphatic-venous or arteriovenous) malformations. Lymphatic malformations may be in various locations (internal and/or external) and can cause various clinical issues, including swelling, pain, and occasionally localized bleeding secondary to trauma. Lipomatous overgrowth may occur ipsilateral or contralateral to a vascular malformation, if present. The degree of intellectual disability appears to be mostly related to the presence and severity of seizures, cortical dysplasia (e.g., polymicrogyria), and hydrocephalus. Many children have feeding difficulties that are often multifactorial in nature. Endocrine issues affect a small number of individuals and most commonly include hypoglycemia (largely hypoinsulinemic hypoketotic hypoglycemia), hypothyroidism, and growth hormone deficiency.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/355421">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_382434"><div><strong>Autoimmune lymphoproliferative syndrome type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382434</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2674723</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">RAS-associated leukoproliferative disorder (RALD) is characterized by lymphadenopathy, splenomegaly, and variable autoimmune phenomena, including autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, and neutropenia. Laboratory studies show an expansion of lymphocytes due to defective apoptosis, as well as significant autoantibodies. Some patients have recurrent infections, and there may be an increased risk of hematologic malignancy (summary by Oliveira, 2013 and Niemela et al., 2010). The disorder shows significant overlap with autoimmune lymphoproliferative syndrome (ALPS; 601859) and was originally designated ALPS IV.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/382434">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_424834"><div><strong>N syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>424834</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2936859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Syndrome that is characterized by intellectual deficit, deafness, ocular anomalies, T-cell leukemia, cryptorchidism, hypospadias and spasticity. Mutations in DNA polymerase alpha, leading to increased chromosome breakage, may be responsible for the syndrome. X-linked recessive transmission has been proposed.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/424834">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_463627"><div><strong>Fanconi anemia complementation group D2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>463627</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3160738</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/463627">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_463628"><div><strong>Fanconi anemia complementation group E</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>463628</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3160739</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/463628">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_481294"><div><strong>Deafness-lymphedema-leukemia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>481294</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3279664</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Primary lymphedema with myelodysplasia, also known as Emberger syndrome, is a rare disorder characterized by childhood-onset lymphedema of the lower limbs, with lymphoscintigraphy suggestive of lymphatic vessel hypoplasia, and genital lymphatic abnormalities. Myelodysplasia is usually with monosomy 7. Multiple warts, deafness, and minor anomalies (mild hypotelorism, neck webbing, and slender fingers) may also be present (summary by Mansour et al., 2010).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/481294">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_483324"><div><strong>Fanconi anemia complementation group C</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>483324</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3468041</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/483324">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_483333"><div><strong>Fanconi anemia complementation group A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>483333</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3469521</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/483333">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_854017"><div><strong>Fanconi anemia complementation group G</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854017</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3469527</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Fanconi anemia (FA) is characterized by physical abnormalities, bone marrow failure, and increased risk for malignancy. Physical abnormalities, present in approximately 75% of affected individuals, include one or more of the following: short stature, abnormal skin pigmentation, skeletal malformations of the upper and/or lower limbs, microcephaly, and ophthalmic and genitourinary tract anomalies. Progressive bone marrow failure with pancytopenia typically presents in the first decade, often initially with thrombocytopenia or leukopenia. The incidence of acute myeloid leukemia is 13% by age 50 years. Solid tumors – particularly of the head and neck, skin, and genitourinary tract – are more common in individuals with FA.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/854017">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766536"><div><strong>Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766536</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553622</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766536">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1639327"><div><strong>Rubinstein-Taybi syndrome due to CREBBP mutations</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1639327</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Rubinstein-Taybi syndrome (RSTS) is characterized by distinctive facial features, broad and often angulated thumbs and halluces, short stature, and moderate-to-severe intellectual disability. Characteristic craniofacial features include downslanted palpebral fissures, low-hanging columella, high palate, grimacing smile, and talon cusps. Prenatal growth is often normal, then height, weight, and head circumference percentiles rapidly drop in the first few months of life. Short stature is typical in adulthood. Obesity may develop in childhood or adolescence. Average IQ ranges between 35 and 50; however, developmental outcome varies considerably. Some individuals with EP300-related RSTS have normal intellect. Additional features include ocular abnormalities, hearing loss, respiratory difficulties, congenital heart defects, renal abnormalities, cryptorchidism, feeding problems, recurrent infections, and severe constipation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1639327">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748029"><div><strong>Mismatch repair cancer syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748029</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399763</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748029">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1790819"><div><strong>Erythroleukemia, familial, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1790819</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5552985</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial erythroleukemia (FERLK) is a leukemic or preleukemic state in which red cell proliferation is the predominant feature. Hematologic characteristics include particularly ineffective and hyperplastic erythropoiesis with megaloblastic components accompanied by myeloblastic proliferation of varying degree (Park et al., 2002). Park et al. (2002) discussed the evolution of the definition of 'erythroleukemia,' which is considered by most to be a subtype of acute myelogenous leukemia (AML; 601626). Controversy about the precise definition of erythroleukemia revolves around the number or percentage of erythroblasts and myeloblasts found in the bone marrow and peripheral circulation. In the French-American-British (FAB) classification system (Bennett et al., 1985), it is known as AML-M6, whereas in the revised World Health Organization (WHO) classification system (Harris et al., 1999), it is known as 'AML, not otherwise categorized' (Zini and D'Onofrio, 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1790819">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1804234"><div><strong>Tessadori-Van Haaften neurodevelopmental syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1804234</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5677016</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tessadori-Bicknell-van Haaften neurodevelopmental syndrome-4 (TEBIVANED4) is characterized by global developmental delay with poor overall growth, variably impaired intellectual development, learning difficulties, distal skeletal anomalies, and dysmorphic facies. Some patients have visual or hearing deficits. The severity and manifestations of the disorder are highly variable (Tessadori et al., 2022). For a discussion of genetic heterogeneity of TEBIVANED, see TEBIVANED1 (619758).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1804234">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841196"><div><strong>Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841196</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830560</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Telomere-related pulmonary fibrosis and/or bone marrow failure syndrome-9 (PFBMFT9) is an autosomal dominant short telomere syndrome characterized by the development of pulmonary fibrosis or hematologic abnormalities, including leukopenia and leukemia, in adulthood. Liver disease may also be present. There is incomplete penetrance and evidence of genetic anticipation. Affected individuals have shortened telomeres, but do not show mucocutaneous manifestations (Kannengiesser et al., 2020). For a discussion of genetic heterogeneity of telomere-related pulmonary fibrosis and/or bone marrow failure, see PFBMFT1 (614742).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841196">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_439" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-telangiectasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382434" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune lymphoproliferative syndrome type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_2685" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bloom syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_481294" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deafness-lymphedema-leukemia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1790819" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythroleukemia, familial, susceptibility to</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (21)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_483333" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_483324" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group C</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_463627" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group D2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_463628" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group E</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_854017" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Fanconi anemia complementation group G</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_320546" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Macroglobulinemia, Waldenstrom, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355421" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Megalencephaly-capillary malformation-polymicrogyria syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748029" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mismatch repair cancer syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338026" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mosaic variegated aneuploidy syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_424834" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">N syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344290" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Noonan syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841196" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766536" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_20552" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Retinoblastoma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1639327" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rubinstein-Taybi syndrome due to CREBBP mutations</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1804234" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tessadori-Van Haaften neurodevelopmental syndrome 4</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36943212">Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shadman M</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Mar 21;329(11):918-932.
|
||
doi: 10.1001/jama.2023.1946.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36943212" target="_blank">36943212</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36066514">Diagnosis and Treatment of Myelodysplastic Syndromes: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sekeres MA,
|
||
Taylor J</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2022 Sep 6;328(9):872-880.
|
||
doi: 10.1001/jama.2022.14578.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36066514" target="_blank">36066514</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29540348">iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hallek M,
|
||
Cheson BD,
|
||
Catovsky D,
|
||
Caligaris-Cappio F,
|
||
Dighiero G,
|
||
Döhner H,
|
||
Hillmen P,
|
||
Keating M,
|
||
Montserrat E,
|
||
Chiorazzi N,
|
||
Stilgenbauer S,
|
||
Rai KR,
|
||
Byrd JC,
|
||
Eichhorst B,
|
||
O'Brien S,
|
||
Robak T,
|
||
Seymour JF,
|
||
Kipps TJ</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2018 Jun 21;131(25):2745-2760.
|
||
Epub 2018 Mar 14
|
||
doi: 10.1182/blood-2017-09-806398.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29540348" target="_blank">29540348</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9760)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36722402">The clinical impact of the molecular landscape of acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kayser S,
|
||
Levis MJ</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2023 Feb 1;108(2):308-320.
|
||
doi: 10.3324/haematol.2022.280801.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36722402" target="_blank">36722402</a><a href="/pmc/articles/PMC9890016" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35050458">Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Long NA,
|
||
Golla U,
|
||
Sharma A,
|
||
Claxton DF</span><br />
|
||
<span class="medgenPMjournal">Stem Cell Rev Rep</span>
|
||
2022 Apr;18(4):1211-1226.
|
||
Epub 2022 Jan 20
|
||
doi: 10.1007/s12015-021-10308-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35050458" target="_blank">35050458</a><a href="/pmc/articles/PMC10942736" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27875373">Revisiting erythroleukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arber DA</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Hematol</span>
|
||
2017 Mar;24(2):146-151.
|
||
doi: 10.1097/MOH.0000000000000314.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27875373" target="_blank">27875373</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27367478">'Acute myeloid leukemia: a comprehensive review and 2016 update'.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Kouchkovsky I,
|
||
Abdul-Hay M</span><br />
|
||
<span class="medgenPMjournal">Blood Cancer J</span>
|
||
2016 Jul 1;6(7):e441.
|
||
doi: 10.1038/bcj.2016.50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27367478" target="_blank">27367478</a><a href="/pmc/articles/PMC5030376" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14552428">Classification of acute leukemias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brunning RD</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2003 Aug;20(3):142-53.
|
||
doi: 10.1016/s0740-2570(03)00031-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14552428" target="_blank">14552428</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (67546)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37054417">Leukemia: The Basics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Am Fam Physician</span>
|
||
2023 Apr;107(4):Online.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37054417" target="_blank">37054417</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29128067">Acute Myeloid Leukemia Immunophenotyping by Flow Cytometric Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen X,
|
||
Cherian S</span><br />
|
||
<span class="medgenPMjournal">Clin Lab Med</span>
|
||
2017 Dec;37(4):753-769.
|
||
Epub 2017 Aug 31
|
||
doi: 10.1016/j.cll.2017.07.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29128067" target="_blank">29128067</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27367478">'Acute myeloid leukemia: a comprehensive review and 2016 update'.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Kouchkovsky I,
|
||
Abdul-Hay M</span><br />
|
||
<span class="medgenPMjournal">Blood Cancer J</span>
|
||
2016 Jul 1;6(7):e441.
|
||
doi: 10.1038/bcj.2016.50.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27367478" target="_blank">27367478</a><a href="/pmc/articles/PMC5030376" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25680783">Leukemias in Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seth R,
|
||
Singh A</span><br />
|
||
<span class="medgenPMjournal">Indian J Pediatr</span>
|
||
2015 Sep;82(9):817-24.
|
||
Epub 2015 Feb 15
|
||
doi: 10.1007/s12098-015-1695-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25680783" target="_blank">25680783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14552428">Classification of acute leukemias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brunning RD</span><br />
|
||
<span class="medgenPMjournal">Semin Diagn Pathol</span>
|
||
2003 Aug;20(3):142-53.
|
||
doi: 10.1016/s0740-2570(03)00031-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14552428" target="_blank">14552428</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (70293)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35852098">Design of the VIALE-M phase III trial of venetoclax and oral azacitidine maintenance therapy in acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ivanov V,
|
||
Yeh SP,
|
||
Mayer J,
|
||
Saini L,
|
||
Unal A,
|
||
Boyiadzis M,
|
||
Hoffman DM,
|
||
Kang K,
|
||
Addo SN,
|
||
Mendes WL,
|
||
Fathi AT</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2022 Aug;18(26):2879-2889.
|
||
Epub 2022 Jul 19
|
||
doi: 10.2217/fon-2022-0450.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35852098" target="_blank">35852098</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30700839">Rethinking clinical trial endpoints in myelodysplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sekeres MA,
|
||
Steensma DP</span><br />
|
||
<span class="medgenPMjournal">Leukemia</span>
|
||
2019 Mar;33(3):570-575.
|
||
Epub 2019 Jan 30
|
||
doi: 10.1038/s41375-018-0367-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30700839" target="_blank">30700839</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27615555">Targeting acute myeloid leukemia with TP53-independent vosaroxin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Benton CB,
|
||
Ravandi F</span><br />
|
||
<span class="medgenPMjournal">Future Oncol</span>
|
||
2017 Jan;13(2):125-133.
|
||
Epub 2016 Sep 12
|
||
doi: 10.2217/fon-2016-0300.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27615555" target="_blank">27615555</a><a href="/pmc/articles/PMC5144553" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25996182">Oncolytic viruses: From bench to bedside with a focus on safety.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buijs PR,
|
||
Verhagen JH,
|
||
van Eijck CH,
|
||
van den Hoogen BG</span><br />
|
||
<span class="medgenPMjournal">Hum Vaccin Immunother</span>
|
||
2015;11(7):1573-84.
|
||
doi: 10.1080/21645515.2015.1037058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25996182" target="_blank">25996182</a><a href="/pmc/articles/PMC4514197" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18318563">Nilotinib.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Plosker GL,
|
||
Robinson DM</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
2008;68(4):449-59; discussion 460-1.
|
||
doi: 10.2165/00003495-200868040-00005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18318563" target="_blank">18318563</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77598)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32940362">Cancer statistics for adolescents and young adults, 2020.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller KD,
|
||
Fidler-Benaoudia M,
|
||
Keegan TH,
|
||
Hipp HS,
|
||
Jemal A,
|
||
Siegel RL</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2020 Nov;70(6):443-459.
|
||
Epub 2020 Sep 17
|
||
doi: 10.3322/caac.21637.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32940362" target="_blank">32940362</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31759344">Cancer Incidence and Mortality in Firefighters: A State-of-the-Art Review and Meta-َAnalysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soteriades ES,
|
||
Kim J,
|
||
Christophi CA,
|
||
Kales SN</span><br />
|
||
<span class="medgenPMjournal">Asian Pac J Cancer Prev</span>
|
||
2019 Nov 1;20(11):3221-3231.
|
||
doi: 10.31557/APJCP.2019.20.11.3221.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31759344" target="_blank">31759344</a><a href="/pmc/articles/PMC7063017" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28573892">Acute myeloid leukemia in the elderly: therapeutic options and choice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Webster JA,
|
||
Pratz KW</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
2018 Feb;59(2):274-287.
|
||
Epub 2017 Jun 2
|
||
doi: 10.1080/10428194.2017.1330956.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28573892" target="_blank">28573892</a><a href="/pmc/articles/PMC7147978" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26742998">Cancer statistics, 2016.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siegel RL,
|
||
Miller KD,
|
||
Jemal A</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2016 Jan-Feb;66(1):7-30.
|
||
Epub 2016 Jan 7
|
||
doi: 10.3322/caac.21332.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26742998" target="_blank">26742998</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17019734">Acute myeloid leukemia: epidemiology and etiology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Deschler B,
|
||
Lübbert M</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2006 Nov 1;107(9):2099-107.
|
||
doi: 10.1002/cncr.22233.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17019734" target="_blank">17019734</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (59819)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36198128">Automated Ascertainment of Typhlitis From the Electronic Health Record.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller TP,
|
||
Li Y,
|
||
Masino AJ,
|
||
Vallee E,
|
||
Burrows E,
|
||
Ramos M,
|
||
Alonzo TA,
|
||
Gerbing R,
|
||
Castellino SM,
|
||
Hawkins DS,
|
||
Lash TL,
|
||
Aplenc R,
|
||
Grundmeier RW</span><br />
|
||
<span class="medgenPMjournal">JCO Clin Cancer Inform</span>
|
||
2022 Sep;6:e2200081.
|
||
doi: 10.1200/CCI.22.00081.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36198128" target="_blank">36198128</a><a href="/pmc/articles/PMC9848554" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30661650">Clinical implications of measurable residual disease in AML: Review of current evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moors I,
|
||
Vandepoele K,
|
||
Philippé J,
|
||
Deeren D,
|
||
Selleslag D,
|
||
Breems D,
|
||
Straetmans N,
|
||
Kerre T,
|
||
Denys B</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2019 Jan;133:142-148.
|
||
Epub 2018 Nov 24
|
||
doi: 10.1016/j.critrevonc.2018.11.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30661650" target="_blank">30661650</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28612456">Day 14 bone marrow examination in the management of acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Terry CM,
|
||
Shallis RM,
|
||
Estey E,
|
||
Lim SH</span><br />
|
||
<span class="medgenPMjournal">Am J Hematol</span>
|
||
2017 Oct;92(10):1079-1084.
|
||
Epub 2017 Jul 19
|
||
doi: 10.1002/ajh.24818.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28612456" target="_blank">28612456</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12409647">Recent advances in breast cancer biology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Domchek SM,
|
||
Weber BL</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Oncol</span>
|
||
2002 Nov;14(6):589-93.
|
||
doi: 10.1097/00001622-200211000-00001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12409647" target="_blank">12409647</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12126839">Minimal residual disease evaluation in acute myeloid leukaemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yin JA,
|
||
Grimwade D</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2002 Jul 13;360(9327):160-2.
|
||
doi: 10.1016/S0140-6736(02)09419-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12126839" target="_blank">12126839</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53864)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37686807">Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kintossou AK,
|
||
Blanco-Lopez J,
|
||
Iguacel I,
|
||
Pisanu S,
|
||
Almeida CCB,
|
||
Steliarova-Foucher E,
|
||
Sierens C,
|
||
Gunter MJ,
|
||
Ladas EJ,
|
||
Barr RD,
|
||
Van Herck K,
|
||
Kozlakidis Z,
|
||
Huybrechts I</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2023 Aug 29;15(17)
|
||
doi: 10.3390/nu15173775.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37686807" target="_blank">37686807</a><a href="/pmc/articles/PMC10489830" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37597401">The effectiveness of play therapy in children with leukemia: A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ramdaniati S,
|
||
Lismidiati W,
|
||
Haryanti F,
|
||
Sitaresmi MN</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Nurs</span>
|
||
2023 Nov-Dec;73:7-21.
|
||
Epub 2023 Aug 18
|
||
doi: 10.1016/j.pedn.2023.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37597401" target="_blank">37597401</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35483397">Antifungal prophylaxis in adult patients with acute myeloid leukaemia treated with novel targeted therapies: a systematic review and expert consensus recommendation from the European Hematology Association.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stemler J,
|
||
de Jonge N,
|
||
Skoetz N,
|
||
Sinkó J,
|
||
Brüggemann RJ,
|
||
Busca A,
|
||
Ben-Ami R,
|
||
Ráčil Z,
|
||
Piechotta V,
|
||
Lewis R,
|
||
Cornely OA</span><br />
|
||
<span class="medgenPMjournal">Lancet Haematol</span>
|
||
2022 May;9(5):e361-e373.
|
||
doi: 10.1016/S2352-3026(22)00073-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35483397" target="_blank">35483397</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33485429">Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yadav V,
|
||
Ganesan P,
|
||
Veeramani R,
|
||
Kumar V D</span><br />
|
||
<span class="medgenPMjournal">Clin Lymphoma Myeloma Leuk</span>
|
||
2021 Jan;21(1):e57-e65.
|
||
Epub 2020 Aug 18
|
||
doi: 10.1016/j.clml.2020.08.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33485429" target="_blank">33485429</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33030517">Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Short NJ,
|
||
Zhou S,
|
||
Fu C,
|
||
Berry DA,
|
||
Walter RB,
|
||
Freeman SD,
|
||
Hourigan CS,
|
||
Huang X,
|
||
Nogueras Gonzalez G,
|
||
Hwang H,
|
||
Qi X,
|
||
Kantarjian H,
|
||
Ravandi F</span><br />
|
||
<span class="medgenPMjournal">JAMA Oncol</span>
|
||
2020 Dec 1;6(12):1890-1899.
|
||
doi: 10.1001/jamaoncol.2020.4600.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33030517" target="_blank">33030517</a><a href="/pmc/articles/PMC7545346" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leukemia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1034)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
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|
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<div class="rightCol mgCol">
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A1%5F1" target="_blank">Analyte (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (12)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A3%5F32" target="_blank">Karyotyping (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (18)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023418%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (14)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0023418%5bDISCUI%5d" target="_blank">See all (43)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Leukemia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
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|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Leukemia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Leukemia" target="_blank">MedlinePlus</a></li></ul></div>
|
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|
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<div class="portlet brieflink">
|
||
<div class="portlet_head">
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<li>
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||
<a href="/pubmed/clinical?term=Leukemia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
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|
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<li>
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||
<a href="/pubmed?term=Leukemia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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|
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|
||
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||
|
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<!-- MedGen supplemental column ends here -->
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<h3>Related information</h3>
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<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023418[DISCUI]" ref="log$=recordlinks">GTR</a>
|
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
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|
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0023418[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=9725" ref="log$=recordlinks">MeSH</a>
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=9725" ref="log$=recordlinks">PMC Articles</a>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=9725" ref="log$=recordlinks">PubMed</a>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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Turn On
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||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d300ef67c23b31e01a390d">Leukemia</a>
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<div class="ralinkpop offscreen_noflow">Leukemia<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d300eb2f30673f7b5215b1">Classic Hodgkin lymphoma</a>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d300d9cde49f3df731208d">Ataxia-Telangiectasia - GeneReviews®</a>
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