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<meta name="keywords" content="C0022575, conjunctival xerosis, disease or syndrome, dry eye syndrome, dry eyes, kcs - keratoconjunctivitis sicca, keratitis sicca, keratoconjunctivitis sicca, sicca, keratoconjunctivitis, xerophthalmia, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=9620
|
||
ConceptID=C0022575
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Keratoconjunctivitis sicca</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9620</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022575</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Xerophthalmia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>KCS - Keratoconjunctivitis sicca (302896008); Keratoconjunctivitis sicca (302896008)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001097">HP:0001097</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0000948" target="_blank">MONDO:0000948</a></td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0022575[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=9620">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Keratoconjunctivitis sicca</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/5092" ref="tree=MeSH" title="MedGen record for Disorder of eye">Disorder of eye</a></span><ul><li><span class="TLline"><a href="/medgen/5994" ref="tree=MeSH" title="MedGen record for Lacrimal apparatus disorder">Lacrimal apparatus disorder</a></span><ul><li><span class="TLline"><a href="/medgen/4411" ref="tree=MeSH" title="MedGen record for Dry eye syndrome">Dry eye syndrome</a></span><ul><li><span class="matched_ds">Keratoconjunctivitis sicca</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_8688"><div><strong>Primary erythromelalgia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8688</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0014805</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">SCN9A neuropathic pain syndromes (SCN9A-NPS) comprise SCN9A erythromelalgia (EM), SCN9A paroxysmal extreme pain disorder (PEPD), and SCN9A small fiber neuropathy (SFN). SCN9A-EM is characterized by recurrent episodes of bilateral intense, burning pain, and redness, warmth, and occasionally swelling. While the feet are more commonly affected than the hands, in severely affected individuals the legs, arms, face, and/or ears may be involved. SCN9A-PEPD is characterized by neonatal or infantile onset of autonomic manifestations that can include skin flushing, harlequin (patchy or asymmetric) color change, tonic non-epileptic attacks (stiffening), and syncope with bradycardia. Later manifestations are episodes of excruciating deep burning rectal, ocular, or submandibular pain accompanied by flushing (erythematous skin changes). SCN9A-SFN is characterized by adult-onset neuropathic pain in a stocking and glove distribution, often with a burning quality; autonomic manifestations such as dry eyes, mouth, orthostatic dizziness, palpitations, bowel or bladder disturbances; and preservation of large nerve fiber functions (normal strength, tendon reflexes, and vibration sense).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8688">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_120536"><div><strong>Autosomal dominant keratitis-ichthyosis-hearing loss syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120536</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265336</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Keratitis-ichthyosis-deafness (KID) syndrome is a rare ectodermal dysplasia characterized by sensorineural hearing loss, photophobia and corneal vascularization, hyperkeratosis of the palms and soles, erythrokeratoderma, follicular hyperkeratosis, and recurrent bacterial and fungal infections. A subset of patients with KID may develop multiple cystic pilar tumors, which are prone to malignant transformation and metastasis (Nyquist et al., 2007). Vohwinkel syndrome (124500) is an allelic disorder involving congenital deafness with keratopachydermia and constrictions of fingers and toes. Another similar disorder caused by mutation in GJB2 is palmoplantar keratoderma with deafness (148350). Genetic Heterogeneity of Keratitis-Ichthyosis-Deafness Syndrome An autosomal recessive form of KID syndrome (KIDAR; 242150) is caused by mutation in the AP1B1 gene (600157) on chromosome 22q12.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120536">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_75656"><div><strong>Xeroderma pigmentosum, group D</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75656</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268138</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Xeroderma pigmentosum (XP) is characterized by: Acute sun sensitivity (severe sunburn with blistering, persistent erythema on minimal sun exposure) with marked freckle-like pigmentation of the face before age two years; Sunlight-induced ocular involvement (photophobia, severe keratitis, atrophy of the skin of the lids, ocular surface neoplasms); Greatly increased risk of sunlight-induced cutaneous neoplasms (basal cell carcinoma, squamous cell carcinoma, melanoma) within the first decade of life. Approximately 25% of affected individuals have neurologic manifestations (acquired microcephaly, diminished or absent deep tendon stretch reflexes, progressive sensorineural hearing loss, progressive cognitive impairment, and ataxia). The most common causes of death are skin cancer, neurologic degeneration, and internal cancer. The median age at death in persons with XP with neurodegeneration (29 years) was found to be younger than that in persons with XP without neurodegeneration (37 years).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75656">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_272036"><div><strong>Trichothiodystrophy 4, nonphotosensitive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>272036</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1313961</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Trichothiodystrophy is a rare autosomal recessive disorder in which patients have brittle, sulfur-deficient hair that displays a diagnostic alternating light and dark banding pattern, called 'tiger tail banding,' under polarizing microscopy. TTD patients display a wide variety of clinical features, including cutaneous, neurologic, and growth abnormalities. Common additional clinical features are ichthyosis, intellectual/developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections. There are both photosensitive and nonphotosensitive forms of the disorder (summary by Faghri et al., 2008). Sabinas brittle hair syndrome (211390) is another form of nonphotosensitive TTD. For a discussion of genetic heterogeneity of trichothiodystrophy, see 601675.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/272036">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_282890"><div><strong>Sjogren syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>282890</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1527336</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sjogren syndrome is an autoimmune disease that mainly affects the exocrine glands. It is clinically characterized by keratoconjunctivitis sicca and xerostomia (Goransson et al., 2006). See 200400 for association of Sjogren syndrome with achalasia in sisters.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/282890">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_395436"><div><strong>Achalasia, familial esophageal</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>395436</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1860213</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Achalasia is a primary motor disorder of the esophagus. It is characterized by aperistalsis and a failure of the lower esophageal sphincter to relax due to a loss of inhibitory nitrinergic neurons in the esophageal myenteric plexus. Patients typically present with dysphagia, regurgitation, retrosternal pain, and substantial weight loss (summary by Farrokhi and Vaezi, 2007 and Gockel et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/395436">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355730"><div><strong>Trichothiodystrophy 1, photosensitive</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355730</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866504</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">About half of all people with trichothiodystrophy have a photosensitive form of the disorder, which causes them to be extremely sensitive to ultraviolet (UV) rays from sunlight. They develop a severe sunburn after spending just a few minutes in the sun. However, for reasons that are unclear, they do not develop other sun-related problems such as excessive freckling of the skin or an increased risk of skin cancer. Many people with trichothiodystrophy report that they do not sweat.\n\nTrichothiodystrophy is also associated with recurrent infections, particularly respiratory infections, which can be life-threatening. People with trichothiodystrophy may have abnormal red blood cells, including red blood cells that are smaller than normal. They may also have elevated levels of a type of hemoglobin called A2, which is a protein found in red blood cells. Other features of trichothiodystrophy can include dry, scaly skin (ichthyosis); abnormalities of the fingernails and toenails; clouding of the lens in both eyes from birth (congenital cataracts); poor coordination; and skeletal abnormalities including degeneration of both hips at an early age.\n\nMothers of children with trichothiodystrophy may experience problems during pregnancy including pregnancy-induced high blood pressure (preeclampsia) and a related condition called HELLP syndrome that can damage the liver. Babies with trichothiodystrophy are at increased risk of premature birth, low birth weight, and slow growth. Most children with trichothiodystrophy have short stature compared to others their age. \n\nThe signs and symptoms of trichothiodystrophy vary widely. Mild cases may involve only the hair. More severe cases also cause delayed development, significant intellectual disability, and recurrent infections; severely affected individuals may survive only into infancy or early childhood.\n\nIn people with trichothiodystrophy, tests show that the hair is lacking sulfur-containing proteins that normally gives hair its strength. A cross section of a cut hair shows alternating light and dark banding that has been described as a "tiger tail."\n\nIntellectual disability and delayed development are common in people with trichothiodystrophy, although most affected individuals are highly social with an outgoing and engaging personality. Some people with trichothiodystrophy have brain abnormalities that can be seen with imaging tests. A common neurological feature of this disorder is impaired myelin production (dysmyelination). Myelin is a fatty substance that insulates nerve cells and promotes the rapid transmission of nerve impulses.\n\nTrichothiodystrophy, commonly called TTD, is a rare inherited condition that affects many parts of the body. The hallmark of this condition is hair that is sparse and easily broken. </div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355730">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863379"><div><strong>Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863379</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014942</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">CAGSSS, which comprises cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia, is an autosomal recessive multisystemic disorder with a highly variable phenotypic spectrum. Not all of these features are always present, and almost all the features may present at different times and/or become more apparent with age. The skeletal features are consistent with spondyloepimetaphyseal dysplasia (SEMD) (summary by Vona et al., 2018). One family had a distinctive presentation with infantile-onset intractable seizures and cortical abnormalities reminiscent of Leigh syndrome (see 256000). The correlation between genotype and phenotype remains unclear, but since the IARS2 gene is involved in mitochondrial function, heterogeneous manifestations can be expected (Takezawa et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863379">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864147"><div><strong>Tenorio syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864147</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015710</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Tenorio syndrome (TNORS) is characterized by overgrowth, macrocephaly, and impaired intellectual development. Some patients may have mild hydrocephaly, hypoglycemia, and inflammatory diseases resembling Sjogren syndrome (270150) (summary by Tenorio et al., 2014).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864147">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934587"><div><strong>Yao syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934587</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310620</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Yao syndrome (YAOS) is an autoinflammatory disease characterized by periodic fever, dermatitis, arthritis, and swelling of the distal extremities, as well as gastrointestinal and sicca-like symptoms. The disorder is associated with specific NOD2 variants (and Shen, 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934587">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934763"><div><strong>Progeroid and marfanoid aspect-lipodystrophy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934763</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310796</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The marfanoid-progeroid-lipodystrophy syndrome (MFLS) is characterized by congenital lipodystrophy, premature birth with an accelerated linear growth disproportionate to weight gain, and progeroid appearance with distinct facial features, including proptosis, downslanting palpebral fissures, and retrognathia. Other characteristic features include arachnodactyly, digital hyperextensibility, myopia, dural ectasia, and normal psychomotor development (Takenouchi et al., 2013). Takenouchi et al. (2013) noted phenotypic overlap with Marfan syndrome (154700) and Shprintzen-Goldberg craniosynostosis syndrome (182212).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934763">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1380109"><div><strong>Autoinflammation with arthritis and dyskeratosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1380109</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479278</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoinflammation with arthritis and dyskeratosis (AIADK) is characterized by recurrent fever, widespread skin dyskeratosis, arthritis, elevated biologic markers of inflammation, and mild autoimmunity with a high transitional B-cell level (summary by Grandemange et al., 2016).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1380109">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1680057"><div><strong>Cerebellar, ocular, craniofacial, and genital syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1680057</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193118</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cerebellar, ocular, craniofacial, and genital syndrome (COFG) is characterized by moderate to severe developmental delay and impaired intellectual development, severe cerebellar hypoplasia, a noticeably short forehead, medially sparse/flared and laterally extended eyebrows, corneal dystrophy, underdeveloped labioscrotal folds, and tufts of hair extruding from the lactiferous ducts with breast and nipple underdevelopment. Additional features such as pontine involvement, retinal degeneration, anteverted nares, and low-set ears have been variably observed (Rad et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1680057">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1763502"><div><strong>IFAP syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1763502</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436607</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Follicular ichthyosis, atrichia, and photophobia syndrome-2 (IFAP2) is characterized by ichthyosis follicularis or follicular hyperkeratosis, sparse to no body hair, and photophobia with corneal lesions. Ultrastructural hair analysis shows trichorrhexis nodosa (Wang et al., 2020). For a discussion of genetic heterogeneity of IFAP syndrome, see IFAP1 (308205).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1763502">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841140"><div><strong>RECON progeroid syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841140</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830504</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">RECON progeroid syndrome (RECON) is a chromosomal instability disorder characterized by postnatal growth retardation, progeroid facial appearance, hypoplastic nose, prominent premaxilla, skin photosensitivity and xeroderma, muscle wasting with reduced subcutaneous fat, and slender elongated thumbs (Abu-Libdeh et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841140">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1854940"><div><strong>Intellectual developmental disorder, x-linked, syndromic 37</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1854940</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935567</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked syndromic intellectual developmental disorder-37 (MRXS37) is a developmental disorder showing phenotypic variability and variable severity. Male mutation carriers tend to be more severely affected than female mutation carriers, some of whom may even be asymptomatic. In general, the disorder is characterized by global developmental delay with delayed walking, speech delay, impaired intellectual development that ranges from borderline low to moderate, and behavioral abnormalities, such as autism and sleeping difficulties. Many patients are able to attend mainstream schools with assistance and work under supervision. Additional more variable features include sensorineural hearing loss, ocular anomalies, feeding difficulties, dysmorphic facial features, inguinal and umbilical hernia, genitourinary defects, congenital heart defects, musculoskeletal anomalies, and endocrine dysfunction, such as hypogonadism or hyperparathyroidism (Shepherdson et al., 2024).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1854940">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1859086"><div><strong>Amyloidosis, hereditary systemic 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1859086</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935572</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary systemic amyloidosis-5 (AMYLD5) is a rare amyloidosis that can affect the viscera, with severe involvement when located in the kidneys and liver. Renal dysfunction of varying severity may be the predominant manifestation. Massive hepatic hemorrhage constitutes the other severe visceral involvement. Dermatologic manifestations are rare (summary by Granel et al., 2005). The various forms of hereditary systemic amyloidosis that do not have peripheral neuropathy as part of the clinical syndrome had been referred to as 'Ostertag type' (Benson, 2005). For a discussion of genetic heterogeneity of hereditary systemic amyloidosis, see AMYLD1 (105210).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1859086">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_395436" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Achalasia, familial esophageal</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1859086" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Amyloidosis, hereditary systemic 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1380109" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoinflammation with arthritis and dyskeratosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120536" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant keratitis-ichthyosis-hearing loss syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863379" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (17)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1680057" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebellar, ocular, craniofacial, and genital syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1763502" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">IFAP syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1854940" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intellectual developmental disorder, x-linked, syndromic 37</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_8688" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary erythromelalgia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934763" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Progeroid and marfanoid aspect-lipodystrophy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841140" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">RECON progeroid syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_282890" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sjogren syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864147" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tenorio syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355730" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Trichothiodystrophy 1, photosensitive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_272036" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Trichothiodystrophy 4, nonphotosensitive</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_75656" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Xeroderma pigmentosum, group D</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934587" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Yao syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36576348">Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheppard J,
|
||
Shen Lee B,
|
||
Periman LM</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2023 Dec;55(1):241-252.
|
||
doi: 10.1080/07853890.2022.2157477.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36576348" target="_blank">36576348</a><a href="/pmc/articles/PMC9809411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35568107">Current trends in pharmaceutical treatment of dry eye disease: A review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohamed HB,
|
||
Abd El-Hamid BN,
|
||
Fathalla D,
|
||
Fouad EA</span><br />
|
||
<span class="medgenPMjournal">Eur J Pharm Sci</span>
|
||
2022 Aug 1;175:106206.
|
||
Epub 2022 May 11
|
||
doi: 10.1016/j.ejps.2022.106206.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35568107" target="_blank">35568107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28610655">The Diagnosis and Treatment of Sjögren's Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stefanski AL,
|
||
Tomiak C,
|
||
Pleyer U,
|
||
Dietrich T,
|
||
Burmester GR,
|
||
Dörner T</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2017 May 26;114(20):354-361.
|
||
doi: 10.3238/arztebl.2017.0354.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28610655" target="_blank">28610655</a><a href="/pmc/articles/PMC5471601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22keratoconjunctivitis%20sicca%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (57)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36576348">Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheppard J,
|
||
Shen Lee B,
|
||
Periman LM</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2023 Dec;55(1):241-252.
|
||
doi: 10.1080/07853890.2022.2157477.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36576348" target="_blank">36576348</a><a href="/pmc/articles/PMC9809411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30594503">Menopause and Dry Eye Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lurati AR</span><br />
|
||
<span class="medgenPMjournal">Nurs Womens Health</span>
|
||
2019 Feb;23(1):71-78.
|
||
Epub 2018 Dec 27
|
||
doi: 10.1016/j.nwh.2018.11.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30594503" target="_blank">30594503</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30178554">Current concepts on Sjögren's syndrome - classification criteria and biomarkers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jonsson R,
|
||
Brokstad KA,
|
||
Jonsson MV,
|
||
Delaleu N,
|
||
Skarstein K</span><br />
|
||
<span class="medgenPMjournal">Eur J Oral Sci</span>
|
||
2018 Oct;126 Suppl 1(Suppl Suppl 1):37-48.
|
||
doi: 10.1111/eos.12536.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30178554" target="_blank">30178554</a><a href="/pmc/articles/PMC6586012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29243035">Systemic lupus erythematosus and ocular involvement: an overview.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dammacco R</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Med</span>
|
||
2018 May;18(2):135-149.
|
||
Epub 2017 Dec 14
|
||
doi: 10.1007/s10238-017-0479-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29243035" target="_blank">29243035</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28610655">The Diagnosis and Treatment of Sjögren's Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stefanski AL,
|
||
Tomiak C,
|
||
Pleyer U,
|
||
Dietrich T,
|
||
Burmester GR,
|
||
Dörner T</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2017 May 26;114(20):354-361.
|
||
doi: 10.3238/arztebl.2017.0354.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28610655" target="_blank">28610655</a><a href="/pmc/articles/PMC5471601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (426)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36576348">Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sheppard J,
|
||
Shen Lee B,
|
||
Periman LM</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
2023 Dec;55(1):241-252.
|
||
doi: 10.1080/07853890.2022.2157477.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36576348" target="_blank">36576348</a><a href="/pmc/articles/PMC9809411" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36165413">Ocular manifestations of rheumatoid arthritis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reddy AK,
|
||
Kolfenbach JR,
|
||
Palestine AG</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Ophthalmol</span>
|
||
2022 Nov 1;33(6):551-556.
|
||
Epub 2022 Sep 16
|
||
doi: 10.1097/ICU.0000000000000890.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36165413" target="_blank">36165413</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35568107">Current trends in pharmaceutical treatment of dry eye disease: A review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mohamed HB,
|
||
Abd El-Hamid BN,
|
||
Fathalla D,
|
||
Fouad EA</span><br />
|
||
<span class="medgenPMjournal">Eur J Pharm Sci</span>
|
||
2022 Aug 1;175:106206.
|
||
Epub 2022 May 11
|
||
doi: 10.1016/j.ejps.2022.106206.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35568107" target="_blank">35568107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736342">TFOS DEWS II Diagnostic Methodology report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wolffsohn JS,
|
||
Arita R,
|
||
Chalmers R,
|
||
Djalilian A,
|
||
Dogru M,
|
||
Dumbleton K,
|
||
Gupta PK,
|
||
Karpecki P,
|
||
Lazreg S,
|
||
Pult H,
|
||
Sullivan BD,
|
||
Tomlinson A,
|
||
Tong L,
|
||
Villani E,
|
||
Yoon KC,
|
||
Jones L,
|
||
Craig JP</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):539-574.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736342" target="_blank">28736342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736335">TFOS DEWS II Definition and Classification Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Craig JP,
|
||
Nichols KK,
|
||
Akpek EK,
|
||
Caffery B,
|
||
Dua HS,
|
||
Joo CK,
|
||
Liu Z,
|
||
Nelson JD,
|
||
Nichols JJ,
|
||
Tsubota K,
|
||
Stapleton F</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):276-283.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736335" target="_blank">28736335</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (530)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36870423">Ocular graft-versus-host disease (oGVHD): From A to Z.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Soleimani M,
|
||
Mahdavi Sharif P,
|
||
Cheraqpour K,
|
||
Koganti R,
|
||
Masoumi A,
|
||
Baharnoori SM,
|
||
Salabati M,
|
||
Djalilian AR</span><br />
|
||
<span class="medgenPMjournal">Surv Ophthalmol</span>
|
||
2023 Jul-Aug;68(4):697-712.
|
||
Epub 2023 Mar 2
|
||
doi: 10.1016/j.survophthal.2023.02.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36870423" target="_blank">36870423</a><a href="/pmc/articles/PMC10293080" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34802085">Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dammacco R,
|
||
Guerriero S,
|
||
Alessio G,
|
||
Dammacco F</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2022 Feb;42(2):689-711.
|
||
Epub 2021 Nov 21
|
||
doi: 10.1007/s10792-021-02058-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34802085" target="_blank">34802085</a><a href="/pmc/articles/PMC8882568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736343">TFOS DEWS II Management and Therapy Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jones L,
|
||
Downie LE,
|
||
Korb D,
|
||
Benitez-Del-Castillo JM,
|
||
Dana R,
|
||
Deng SX,
|
||
Dong PN,
|
||
Geerling G,
|
||
Hida RY,
|
||
Liu Y,
|
||
Seo KY,
|
||
Tauber J,
|
||
Wakamatsu TH,
|
||
Xu J,
|
||
Wolffsohn JS,
|
||
Craig JP</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):575-628.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736343" target="_blank">28736343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28610655">The Diagnosis and Treatment of Sjögren's Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stefanski AL,
|
||
Tomiak C,
|
||
Pleyer U,
|
||
Dietrich T,
|
||
Burmester GR,
|
||
Dörner T</span><br />
|
||
<span class="medgenPMjournal">Dtsch Arztebl Int</span>
|
||
2017 May 26;114(20):354-361.
|
||
doi: 10.3238/arztebl.2017.0354.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28610655" target="_blank">28610655</a><a href="/pmc/articles/PMC5471601" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27754718">Investigational drugs in dry eye disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nebbioso M,
|
||
Fameli V,
|
||
Gharbiya M,
|
||
Sacchetti M,
|
||
Zicari AM,
|
||
Lambiase A</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Investig Drugs</span>
|
||
2016 Dec;25(12):1437-1446.
|
||
Epub 2016 Oct 28
|
||
doi: 10.1080/13543784.2016.1249564.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27754718" target="_blank">27754718</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (381)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29338780">Coping with dry eyes: a qualitative approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yeo S,
|
||
Tong L</span><br />
|
||
<span class="medgenPMjournal">BMC Ophthalmol</span>
|
||
2018 Jan 16;18(1):8.
|
||
doi: 10.1186/s12886-018-0671-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29338780" target="_blank">29338780</a><a href="/pmc/articles/PMC5771005" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736343">TFOS DEWS II Management and Therapy Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jones L,
|
||
Downie LE,
|
||
Korb D,
|
||
Benitez-Del-Castillo JM,
|
||
Dana R,
|
||
Deng SX,
|
||
Dong PN,
|
||
Geerling G,
|
||
Hida RY,
|
||
Liu Y,
|
||
Seo KY,
|
||
Tauber J,
|
||
Wakamatsu TH,
|
||
Xu J,
|
||
Wolffsohn JS,
|
||
Craig JP</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):575-628.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736343" target="_blank">28736343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18188039">Idiopathic sclerosing peritonitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koak Y,
|
||
Gertner D,
|
||
Forbes A,
|
||
Ribeiro BF</span><br />
|
||
<span class="medgenPMjournal">Eur J Gastroenterol Hepatol</span>
|
||
2008 Feb;20(2):148-50.
|
||
doi: 10.1097/MEG.0b013e3282cf4d98.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18188039" target="_blank">18188039</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8654023">Sjögren's syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rothschild BM</span><br />
|
||
<span class="medgenPMjournal">Compr Ther</span>
|
||
1996 Jan;22(1):39-43.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8654023" target="_blank">8654023</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1813522">Keratoconjunctivitis sicca.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roberts DK</span><br />
|
||
<span class="medgenPMjournal">J Am Optom Assoc</span>
|
||
1991 Mar;62(3):187-99.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1813522" target="_blank">1813522</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (179)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34802085">Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dammacco R,
|
||
Guerriero S,
|
||
Alessio G,
|
||
Dammacco F</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2022 Feb;42(2):689-711.
|
||
Epub 2021 Nov 21
|
||
doi: 10.1007/s10792-021-02058-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34802085" target="_blank">34802085</a><a href="/pmc/articles/PMC8882568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33981106">Development in Tear Film Osmolarity Assessments: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fagehi R</span><br />
|
||
<span class="medgenPMjournal">Nepal J Ophthalmol</span>
|
||
2021 Jan;13(25):122-132.
|
||
doi: 10.3126/nepjoph.v13i1.26128.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33981106" target="_blank">33981106</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736343">TFOS DEWS II Management and Therapy Report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jones L,
|
||
Downie LE,
|
||
Korb D,
|
||
Benitez-Del-Castillo JM,
|
||
Dana R,
|
||
Deng SX,
|
||
Dong PN,
|
||
Geerling G,
|
||
Hida RY,
|
||
Liu Y,
|
||
Seo KY,
|
||
Tauber J,
|
||
Wakamatsu TH,
|
||
Xu J,
|
||
Wolffsohn JS,
|
||
Craig JP</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):575-628.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736343" target="_blank">28736343</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28736342">TFOS DEWS II Diagnostic Methodology report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wolffsohn JS,
|
||
Arita R,
|
||
Chalmers R,
|
||
Djalilian A,
|
||
Dogru M,
|
||
Dumbleton K,
|
||
Gupta PK,
|
||
Karpecki P,
|
||
Lazreg S,
|
||
Pult H,
|
||
Sullivan BD,
|
||
Tomlinson A,
|
||
Tong L,
|
||
Villani E,
|
||
Yoon KC,
|
||
Jones L,
|
||
Craig JP</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2017 Jul;15(3):539-574.
|
||
Epub 2017 Jul 20
|
||
doi: 10.1016/j.jtos.2017.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28736342" target="_blank">28736342</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17182405">Complications of blepharoplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morax S,
|
||
Touitou V</span><br />
|
||
<span class="medgenPMjournal">Orbit</span>
|
||
2006 Dec;25(4):303-18.
|
||
doi: 10.1080/01676830600985841.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17182405" target="_blank">17182405</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (321)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34802085">Natural and iatrogenic ocular manifestations of rheumatoid arthritis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dammacco R,
|
||
Guerriero S,
|
||
Alessio G,
|
||
Dammacco F</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2022 Feb;42(2):689-711.
|
||
Epub 2021 Nov 21
|
||
doi: 10.1007/s10792-021-02058-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34802085" target="_blank">34802085</a><a href="/pmc/articles/PMC8882568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33124107">Therapeutic effects of acupuncture in typical dry eye: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Na JH,
|
||
Jung JH,
|
||
Park JG,
|
||
Song PH,
|
||
Song CH</span><br />
|
||
<span class="medgenPMjournal">Acta Ophthalmol</span>
|
||
2021 Aug;99(5):489-498.
|
||
Epub 2020 Oct 29
|
||
doi: 10.1111/aos.14651.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33124107" target="_blank">33124107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32358156">Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Turk MA,
|
||
Hayworth JL,
|
||
Nevskaya T,
|
||
Pope JE</span><br />
|
||
<span class="medgenPMjournal">J Rheumatol</span>
|
||
2021 Jan 1;48(1):25-34.
|
||
Epub 2020 May 1
|
||
doi: 10.3899/jrheum.190768.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32358156" target="_blank">32358156</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26197421">Systemic lupus erythematosus: An update for ophthalmologists.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Papagiannuli E,
|
||
Rhodes B,
|
||
Wallace GR,
|
||
Gordon C,
|
||
Murray PI,
|
||
Denniston AK</span><br />
|
||
<span class="medgenPMjournal">Surv Ophthalmol</span>
|
||
2016 Jan-Feb;61(1):65-82.
|
||
Epub 2015 Jul 18
|
||
doi: 10.1016/j.survophthal.2015.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26197421" target="_blank">26197421</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26045239">Efficacy and Safety of Topical 0.05% Cyclosporine Eye Drops in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wan KH,
|
||
Chen LJ,
|
||
Young AL</span><br />
|
||
<span class="medgenPMjournal">Ocul Surf</span>
|
||
2015 Jul;13(3):213-25.
|
||
Epub 2015 Apr 11
|
||
doi: 10.1016/j.jtos.2014.12.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26045239" target="_blank">26045239</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconjunctivitis%20sicca%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
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|
||
<div class=" bottom">
|
||
|
||
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
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|
||
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0022575%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0022575%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0022575%5bDISCUI%5d" target="_blank">See all (1)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Keratoconjunctivitis%20sicca" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22keratoconjunctivitis%20sicca%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Keratoconjunctivitis%20sicca%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<a href="/pubmed/clinical?term=Keratoconjunctivitis%20sicca" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<a href="/pubmed?term=Keratoconjunctivitis%20sicca%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0022575[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0022575[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=9620" ref="log$=recordlinks">MeSH</a>
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
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Turn On
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<ul id="activity">
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<li class="ra_rcd ralinkpopper two_line">
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||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d5402e2f30673f7b930619">Keratoconjunctivitis sicca</a>
|
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<div class="ralinkpop offscreen_noflow">Keratoconjunctivitis sicca<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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