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<!--
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UID=96101
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ConceptID=C0423776
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Palmar pits</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>96101</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0423776</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Palmar pit</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Palmar pit (247449001)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0010610">HP:0010610</a></td></tr>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Palmar pits</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871273" ref="tree=MeSH" title="MedGen record for Abnormality of the integument">Abnormality of the integument</a></span><ul><li><span class="TLline"><a href="/medgen/1845238" ref="tree=MeSH" title="MedGen record for Abnormality of the skin">Abnormality of the skin</a></span><ul><li><span class="TLline"><a href="/medgen/869110" ref="tree=MeSH" title="MedGen record for Abnormal skin morphology">Abnormal skin morphology</a></span><ul><li><span class="TLline"><a href="/medgen/208858" ref="tree=MeSH" title="MedGen record for Localized skin lesion">Localized skin lesion</a></span><ul><li><span class="TLline"><a href="/medgen/892547" ref="tree=MeSH" title="MedGen record for Skin pit">Skin pit</a></span><ul><li><span class="matched_ds">Palmar pits</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_2554"><div><strong>Gorlin syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>2554</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004779</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple jaw keratocysts, frequently beginning in the second decade of life, and/or basal cell carcinomas (BCCs), usually from the third decade onward. Many individuals have a recognizable appearance with macrocephaly, frontal bossing, coarse facial features, and facial milia. Most individuals have skeletal anomalies (e.g., bifid ribs, wedge-shaped vertebrae). Ectopic calcification, particularly in the falx, is present in 90% of affected individuals by age 30 years. Cardiac and ovarian fibromas occur in approximately 2% and 20% of individuals, respectively. Approximately 5% of all children with NBCCS develop medulloblastoma (primitive neuroectodermal tumor), generally the desmoplastic subtype. The risk of developing medulloblastoma is substantially higher in individuals with an SUFU pathogenic variant (33%) than in those with a PTCH1 pathogenic variant (<2%). Peak incidence is at age one to two years. Life expectancy in NBCCS is not significantly different from average.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/2554">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_5956"><div><strong>Keratosis follicularis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5956</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022595</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Darier-White disease (DAR), also known as keratosis follicularis, is an autosomal dominant skin disorder characterized by warty papules and plaques in seborrheic areas (central trunk, flexures, scalp, and forehead), palmoplantar pits, and distinctive nail abnormalities (Sakuntabhai et al., 1999). Onset is usually before the third decade, and penetrance is complete in adults, although expressivity is variable. Involvement may be severe, with widespread itchy malodorous crusted plaques, painful erosions, blistering, and mucosal lesions. Secondary infection is common. Sun, heat, and sweating exacerbate the symptoms. Darier disease never remits, but oral retinoids may reduce hyperkeratosis. Neuropsychiatric abnormalities, including mild mental retardation and epilepsy, have been described in association with Darier disease in a few families (Burge and Wilkinson, 1992); whether this is an association based on pleiotropism of the mutant gene or reflects coincidence is not clear. Histologic findings are (1) mild nonspecific perivascular infiltration in the dermis; (2) dermal villi protruding into the epidermis; (3) suprabasal detachment of the spinal layer leading to the formation of lacunae containing acantholytic cells; (4) in the more superficial epidermis, dyskeratotic round epidermal cells ('corps ronds'), the most distinctive feature; and (5) in the stratum corneum, 'grains' that resemble parakeratotic cells embedded in a hyperkeratotic horny layer. Electron microscopy reveals loss of desmosomal attachments, perinuclear aggregations of keratin filaments, and cytoplasmic vacuolization. Ultrastructural and immunologic studies suggest the disease results from an abnormality in the desmosome-keratin filament complex leading to a breakdown in cell adhesion.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/5956">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_343009"><div><strong>Generalized basaloid follicular hamartoma syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>343009</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853919</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Generalized basaloid follicular hamartoma syndrome is a rare, genetic skin disease characterized by multiple milium-like, comedone-like lesions and skin-colored to hyperpigmented, 1 to 2 mm-sized papules, associated with hypotrichosis and palmar/plantar pits. Lesions are usually first noticed on cheeks or neck and gradually increase in size and number to involve the scalp, face, ears, shoulders, chest, axillas, and upper arms. In severe cases, lower back, lower arms, and back of the legs can be involved. Mild hypohidrosis has also been reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/343009">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816616"><div><strong>Dowling-degos disease 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816616</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3810286</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dowling-Degos disease-3 (DDD3) is an autosomal dominant disorder characterized by progressive spotted and reticulate pigmentation of the flexures (summary by Li et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of Dowling-Degos disease, see DDD1 (179850).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816616">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648390"><div><strong>Epidermodysplasia verruciformis, susceptibility to, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648390</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748876</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Epidermodysplasia verruciformis-3 (EV3) is characterized by onset in childhood or early adulthood of persistent disseminated flat warts and pityriasis versicolor-like lesions of the skin that are induced by cutaneous human papillomaviruses (HPVs) of the beta genus. Some patients develop nonmelanoma skin cancer, particularly on areas of the body exposed to the sun. Patients are otherwise healthy and normally resistant to other microorganisms, including other viruses and skintropic pathogens, and even all other cutaneous and mucosal HPVs (de Jong et al., 2018). For a discussion of genetic heterogeneity of susceptibility to epidermodysplasia verruciformis, see EV1 (226400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648390">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841087"><div><strong>Basal cell nevus syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841087</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830451</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The basal cell nevus syndrome (BCNS), also known as Gorlin syndrome, is characterized by numerous basal cell cancers and epidermal cysts of the skin, calcified dural folds, keratocysts of the jaws, palmar and plantar pits, ovarian fibromas, medulloblastomas, lymphomesenteric cysts, fetal rhabdomyomas, and various stigmata of maldevelopment (e.g., rib and vertebral abnormalities, cleft lip or cleft palate, and cortical defects of bones) (summary by Koch et al., 2002). For a discussion of genetic heterogeneity of BCNS, see BCNS1 (109400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841087">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841087" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Basal cell nevus syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816616" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dowling-degos disease 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648390" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epidermodysplasia verruciformis, susceptibility to, 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_343009" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Generalized basaloid follicular hamartoma syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_2554" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gorlin syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_5956" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Keratosis follicularis</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/17649773">Diagnosis and treatment of patients with nevoid basal cell carcinoma syndrome [Gorlin-Goltz syndrome (GGS)].</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Friedrich RE</span><br />
|
||
<span class="medgenPMjournal">Anticancer Res</span>
|
||
2007 Jul-Aug;27(4A):1783-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17649773" target="_blank">17649773</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22palmar%20pits%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36436193">Clinical, radiographic, pathological and inherited characteristics of odontogenic keratocyst in nevoid basal cell carcinoma syndrome: a study in three Chilean families.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castillo-Tobar A,
|
||
Urzúa B,
|
||
Tirreau V,
|
||
Donoso F,
|
||
Pinares J,
|
||
Cosmelli-Maturana R,
|
||
Ortega-Pinto A</span><br />
|
||
<span class="medgenPMjournal">Oral Radiol</span>
|
||
2023 Jul;39(3):518-527.
|
||
Epub 2022 Nov 27
|
||
doi: 10.1007/s11282-022-00664-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36436193" target="_blank">36436193</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32807196">Cowden syndrome is a risk factor for multiple neoplasm: a case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miguelote S,
|
||
Silva R,
|
||
Fougo JL,
|
||
Barbosa LE,
|
||
Araújo Teixeira JP</span><br />
|
||
<span class="medgenPMjournal">World J Surg Oncol</span>
|
||
2020 Aug 17;18(1):211.
|
||
doi: 10.1186/s12957-020-01971-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32807196" target="_blank">32807196</a><a href="/pmc/articles/PMC7433065" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15727640">Darier's disease in Singapore.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goh BK,
|
||
Ang P,
|
||
Goh CL</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
2005 Feb;152(2):284-8.
|
||
doi: 10.1111/j.1365-2133.2004.06364.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15727640" target="_blank">15727640</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11382639">Basal cell carcinoma of the eyelid associated with Gorlin-Goltz syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Honavar SG,
|
||
Shields JA,
|
||
Shields CL,
|
||
Eagle RC Jr,
|
||
Demirci H,
|
||
Mahmood EZ</span><br />
|
||
<span class="medgenPMjournal">Ophthalmology</span>
|
||
2001 Jun;108(6):1115-23.
|
||
doi: 10.1016/s0161-6420(01)00560-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11382639" target="_blank">11382639</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9096761">Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kimonis VE,
|
||
Goldstein AM,
|
||
Pastakia B,
|
||
Yang ML,
|
||
Kase R,
|
||
DiGiovanna JJ,
|
||
Bale AE,
|
||
Bale SJ</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet</span>
|
||
1997 Mar 31;69(3):299-308.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9096761" target="_blank">9096761</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Palmar%20pits%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/20501781">Multiple palmar pits and basal cell carcinomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pereyra-Rodríguez JJ,
|
||
Bernabeu-Wittel J,
|
||
Conejo-Mir J</span><br />
|
||
<span class="medgenPMjournal">CMAJ</span>
|
||
2010 Aug 10;182(11):E533.
|
||
Epub 2010 May 25
|
||
doi: 10.1503/cmaj.090884.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20501781" target="_blank">20501781</a><a href="/pmc/articles/PMC2917965" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18645145">Multiple facial papules and palmar pits.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fulchiero GJ Jr,
|
||
Jones CR,
|
||
Billingsley EM</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol</span>
|
||
2008 Jul;144(7):933-8.
|
||
doi: 10.1001/archderm.144.7.933-d.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18645145" target="_blank">18645145</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11138543">Reticulate acropigmentation of Kitamura: first case reports from Nepal.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Joshi A,
|
||
Sah SP</span><br />
|
||
<span class="medgenPMjournal">J Dermatol</span>
|
||
2000 Nov;27(11):745-7.
|
||
doi: 10.1111/j.1346-8138.2000.tb02270.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11138543" target="_blank">11138543</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9096761">Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kimonis VE,
|
||
Goldstein AM,
|
||
Pastakia B,
|
||
Yang ML,
|
||
Kase R,
|
||
DiGiovanna JJ,
|
||
Bale AE,
|
||
Bale SJ</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet</span>
|
||
1997 Mar 31;69(3):299-308.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9096761" target="_blank">9096761</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2370338">Palmar pits and multiple trichoepitheliomas: an association.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lloyd KM,
|
||
Lloyd JR,
|
||
Fatteh S</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Dermatol</span>
|
||
1990 Jun;22(6 Pt 1):1109-10.
|
||
doi: 10.1016/s0190-9622(08)81016-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2370338" target="_blank">2370338</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Palmar%20pits%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25333075">Unusual clinical manifestations in a case of Alagille syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gadkari R,
|
||
Doshi B,
|
||
Nayak C,
|
||
Ghildiyal R,
|
||
Madke B,
|
||
Ghia D</span><br />
|
||
<span class="medgenPMjournal">Pediatr Dermatol</span>
|
||
2014 Sep-Oct;31(5):599-602.
|
||
doi: 10.1111/pde.12132.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25333075" target="_blank">25333075</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19397566">Delayed diagnosis of Gorlin's syndrome in a renal transplant recipient.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mackenzie KA,
|
||
Maurice PD</span><br />
|
||
<span class="medgenPMjournal">Australas J Dermatol</span>
|
||
2009 May;50(2):121-4.
|
||
doi: 10.1111/j.1440-0960.2009.00520.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19397566" target="_blank">19397566</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11123446">Cornifying Darier's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Katta R,
|
||
Reed J,
|
||
Wolf JE</span><br />
|
||
<span class="medgenPMjournal">Int J Dermatol</span>
|
||
2000 Nov;39(11):844-5.
|
||
doi: 10.1046/j.1365-4362.2000.00994.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11123446" target="_blank">11123446</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7425663">Nevoid basal cell carcinoma syndrome. Multiple basal cell carcinomas of the palms after radiation therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golitz LE,
|
||
Norris DA,
|
||
Luekens CA Jr,
|
||
Charles DM</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol</span>
|
||
1980 Oct;116(10):1159-63.
|
||
doi: 10.1001/archderm.116.10.1159.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7425663" target="_blank">7425663</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/133705">Sarcoidosis in a child, presenting as an erythroderma with keratotic spines and palmar pits.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morrison JG</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
1976 Jul;95(1):93-7.
|
||
doi: 10.1111/j.1365-2133.1976.tb15538.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/133705" target="_blank">133705</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Palmar%20pits%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32807196">Cowden syndrome is a risk factor for multiple neoplasm: a case report.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miguelote S,
|
||
Silva R,
|
||
Fougo JL,
|
||
Barbosa LE,
|
||
Araújo Teixeira JP</span><br />
|
||
<span class="medgenPMjournal">World J Surg Oncol</span>
|
||
2020 Aug 17;18(1):211.
|
||
doi: 10.1186/s12957-020-01971-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32807196" target="_blank">32807196</a><a href="/pmc/articles/PMC7433065" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25117323">Multiple nevoid basal cell carcinoma syndrome associated with congenital orbital teratoma, caused by a PTCH1 frameshift mutation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rodrigues AL,
|
||
Carvalho A,
|
||
Cabral R,
|
||
Carneiro V,
|
||
Gilardi P,
|
||
Duarte CP,
|
||
Puente-Prieto J,
|
||
Santos P,
|
||
Mota-Vieira L</span><br />
|
||
<span class="medgenPMjournal">Genet Mol Res</span>
|
||
2014 Jul 25;13(3):5654-63.
|
||
doi: 10.4238/2014.July.25.21.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25117323" target="_blank">25117323</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16301862">Clinical testing for the nevoid basal cell carcinoma syndrome in a DNA diagnostic laboratory.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klein RD,
|
||
Dykas DJ,
|
||
Bale AE</span><br />
|
||
<span class="medgenPMjournal">Genet Med</span>
|
||
2005 Nov-Dec;7(9):611-9.
|
||
doi: 10.1097/01.gim.0000182879.57182.b4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16301862" target="_blank">16301862</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15727640">Darier's disease in Singapore.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goh BK,
|
||
Ang P,
|
||
Goh CL</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
2005 Feb;152(2):284-8.
|
||
doi: 10.1111/j.1365-2133.2004.06364.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15727640" target="_blank">15727640</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1390140">The phenotype of Darier's disease: penetrance and expressivity in adults and children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Munro CS</span><br />
|
||
<span class="medgenPMjournal">Br J Dermatol</span>
|
||
1992 Aug;127(2):126-30.
|
||
doi: 10.1111/j.1365-2133.1992.tb08044.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1390140" target="_blank">1390140</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Palmar%20pits%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/18627702">Asymptomatic palmar pits: clinical evaluation of six cases and review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De D,
|
||
Narang T,
|
||
Dogra S,
|
||
Kanwar AJ</span><br />
|
||
<span class="medgenPMjournal">J Cutan Med Surg</span>
|
||
2008 Jul-Aug;12(4):198-202.
|
||
doi: 10.2310/7750.2008.07022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18627702" target="_blank">18627702</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16301862">Clinical testing for the nevoid basal cell carcinoma syndrome in a DNA diagnostic laboratory.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klein RD,
|
||
Dykas DJ,
|
||
Bale AE</span><br />
|
||
<span class="medgenPMjournal">Genet Med</span>
|
||
2005 Nov-Dec;7(9):611-9.
|
||
doi: 10.1097/01.gim.0000182879.57182.b4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16301862" target="_blank">16301862</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10522671">Multiple hereditary infundibulocystic basal cell carcinomas: a genodermatosis different from nevoid basal cell carcinoma syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Requena L,
|
||
Fariña MC,
|
||
Robledo M,
|
||
Sangueza OP,
|
||
Sanchez E,
|
||
Villanueva A,
|
||
Marquina A,
|
||
Tamarit R</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol</span>
|
||
1999 Oct;135(10):1227-35.
|
||
doi: 10.1001/archderm.135.10.1227.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10522671" target="_blank">10522671</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7962960">Spectrum of reticulate flexural and acral pigmentary disorders in northern India.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dhar S,
|
||
Kanwar AJ,
|
||
Jebraili R,
|
||
Dawn G,
|
||
Das A</span><br />
|
||
<span class="medgenPMjournal">J Dermatol</span>
|
||
1994 Aug;21(8):598-603.
|
||
doi: 10.1111/j.1346-8138.1994.tb01801.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7962960" target="_blank">7962960</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/123965">Kinetics of cell proliferation in benigh and premalignant tumors of the human epidermis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heenen M,
|
||
Lambert JC,
|
||
Achten G,
|
||
Galand P</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
1975 Apr;54(4):825-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/123965" target="_blank">123965</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Palmar%20pits%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22palmar%20pits%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Palmar%20pits%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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