publicdata/nih-gov
1
0
Fork 0
Code Issues Pull requests Projects Releases Packages Wiki Activity Actions
nih-gov/www.ncbi.nlm.nih.gov/medgen/9283

1466 lines
No EOL
160 KiB
XML
Raw Permalink Blame History

This file contains invisible Unicode characters

This file contains invisible Unicode characters that are indistinguishable to humans but may be processed differently by a computer. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en">
<head xmlns:xi="http://www.w3.org/2001/XInclude"><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<!-- meta -->
<meta name="keywords" content="C0019829, chl, classic hodgkin disease, classic hodgkin lymphoma, classical hodgkin lymphoma, classical hodgkin's lymphoma, disease, hodgkin, disease, hodgkin's, disease, hodgkins, familial hodgkin disease, granuloma, hodgkin, granuloma, hodgkin's, granuloma, hodgkins, granuloma, malignant, hd - hodgkin's disease, hodgkin disease, hodgkin granuloma, hodgkin lymphoma, hodgkin lymphoma, susceptibility to, hodgkin's disease, hodgkin's disease (clinical), hodgkin's granuloma, hodgkin's granuloma (clinical), hodgkin's lymphoma, hodgkin's paragranuloma, hodgkin's paragranuloma (clinical), hodgkins disease, hodgkins granuloma, hodgkins lymphoma, klhdc8b, lymphogranuloma, malignant, lymphogranulomas, malignant, lymphoma, hodgkin, lymphoma, hodgkin's, lymphoma, hodgkin, classic, lymphoma, hodgkins, malignant granuloma, malignant granulomas, malignant hodgkin's lymphoma, malignant lymphogranuloma, malignant lymphogranulomas, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009)." /><meta name="robots" content="index,nofollow,noarchive" />
<meta name="ncbi_app" content="entrez" /><meta name="ncbi_db" content="medgen" /><meta name="ncbi_report" content="fullreport" /><meta name="ncbi_format" content="html" /><meta name="ncbi_pagesize" content="20" /><meta name="ncbi_sortorder" content="default" /><meta name="ncbi_pageno" content="1" /><meta name="ncbi_resultcount" content="1" /><meta name="ncbi_op" content="retrieve" /><meta name="ncbi_pdid" content="fullreport" /><meta name="ncbi_sessionid" content="CE8B5AF87C7FFCB1_0191SID" /><meta name="ncbi_uidlist" content="9283" /><meta name="ncbi_filter" content="clinical" /><meta name="ncbi_stat" content="false" /><meta name="ncbi_hitstat" content="false" />
<!-- title -->
<title>Classic Hodgkin lymphoma (Concept Id: C0019829)
- MedGen - NCBI</title>
<!-- Common JS and CSS -->
<script type="text/javascript">
var ncbi_startTime = new Date();
</script>
<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.15.10/js/jig.min.js"></script>
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer/" />
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8C83B97D2FE1810000000000420031.m_29" /><script type="text/javascript"><!--
var ScriptPath = '/portal/';
var objHierarchy = {"name":"EntrezSystem2","type":"Layout","realname":"EntrezSystem2",
"children":[{"name":"EntrezSystem2.PEntrez","type":"Cluster","realname":"EntrezSystem2.PEntrez",
"children":[{"name":"EntrezSystem2.PEntrez.DbConnector","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.DbConnector","shortname":"DbConnector"},
{"name":"EntrezSystem2.PEntrez.ParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.ParamContainer","shortname":"ParamContainer"},
{"name":"EntrezSystem2.PEntrez.MyNcbi","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.MyNcbi","shortname":"MyNcbi"},
{"name":"EntrezSystem2.PEntrez.UserPreferenceUrlParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.UserPreferenceUrlParamContainer","shortname":"UserPreferenceUrlParamContainer"},
{"name":"EntrezSystem2.PEntrez.GridProperty","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.GridProperty","shortname":"GridProperty"},
{"name":"EntrezSystem2.PEntrez.MedGen","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen",
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NoPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NoPortlet","shortname":"NoPortlet"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_PageController","shortname":"MedGen_PageController"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_SearchBar","shortname":"MedGen_SearchBar"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_BotRequest","shortname":"MedGen_BotRequest"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_LimitsTab","shortname":"MedGen_LimitsTab"},
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Facets","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Facets","shortname":"Entrez_Facets"},
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Clipboard","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Clipboard","shortname":"Entrez_Clipboard"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_StaticParts","shortname":"MedGen_StaticParts"},
{"name":"EntrezSystem2.PEntrez.MedGen.Entrez_Messages","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.Entrez_Messages","shortname":"Entrez_Messages"},
{"name":"EntrezSystem2.PEntrez.MedGen.NcbiJSCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NcbiJSCheck","shortname":"NcbiJSCheck"},
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic",
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.Footer_ExtraData","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.Footer_ExtraData","shortname":"Footer_ExtraData"},
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic",
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","shortname":"NCBIBreadcrumbs"},
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","shortname":"NCBIHelpDesk"},
{"name":"EntrezSystem2.PEntrez.MedGen.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","shortname":"NCBIApplog_NoScript_Ping"}]}]},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel",
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.blankToolPanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.blankToolPanel","shortname":"blankToolPanel"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController","shortname":"MedGen_ResultsController"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_FiltersPortlet","shortname":"MedGen_FiltersPortlet"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Pager","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Pager","shortname":"Entrez_Pager"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar","shortname":"MedGen_DisplayBar"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HelpFormAttributes","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HelpFormAttributes","shortname":"HelpFormAttributes"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_Collections","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Entrez_Collections","shortname":"Entrez_Collections"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SpellCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SpellCheck","shortname":"SpellCheck"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.SearchEngineReferralCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.SearchEngineReferralCheck","shortname":"SearchEngineReferralCheck"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.WrongDbSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.WrongDbSensor","shortname":"WrongDbSensor"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.KnowledgePanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.KnowledgePanel","shortname":"KnowledgePanel"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.HistoryDisplay","shortname":"HistoryDisplay"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Discovery_SearchDetails","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.Entrez_ResultsPanel.Discovery_SearchDetails","shortname":"Discovery_SearchDetails"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.mg_GeneSensor","shortname":"mg_GeneSensor"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ClinFeatureSearch","shortname":"MedGen_ClinFeatureSearch"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_RVFull","shortname":"MedGen_RVFull"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster","type":"Cluster","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster",
"children":[{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks","shortname":"MedGenDiscoveryDbLinks"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGen_SingleItemSupl","shortname":"MedGen_SingleItemSupl"},
{"name":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","type":"Portlet","realname":"EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews","shortname":"MedGenReviews"}]}]}]}]}]};
--></script>
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3808861/3917732/3974050/3751656/3395415/4221762/14534/4062871/4186458/4075711/12930/4033350/4128070/3861632/4013176/4212357/4064428/4186491/9685/2279/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/css/3501913/1303451.css" media="print" /><script type="text/javascript">
var ObjectLinks=[{i:0, ename: "p$ExL", esid:"*", sname: "p$ExL", ssid:"*", dname:"p$el", dsid:"0",m:"CopyValue",p:[],f: function(src, dst) {fn_CopyValue(src, dst);}}]
var ActiveNames = {"p$ExL":1, "EntrezSystem2.PEntrez.DbConnector.Cmd":0, "EntrezSystem2.PEntrez.DbConnector.Db":0, "EntrezSystem2.PEntrez.DbConnector.IdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastDb":0, "EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastQueryKey":0, "EntrezSystem2.PEntrez.DbConnector.LastTabCmd":0, "EntrezSystem2.PEntrez.DbConnector.LinkName":0, "EntrezSystem2.PEntrez.DbConnector.LinkReadableName":0, "EntrezSystem2.PEntrez.DbConnector.LinkSrcDb":0, "EntrezSystem2.PEntrez.DbConnector.QueryKey":0, "EntrezSystem2.PEntrez.DbConnector.TabCmd":0, "EntrezSystem2.PEntrez.DbConnector.Term":0, "EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter":0, "EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter":0};
</script></head>
<body>
<div class="grid">
<div class="col twelve_col nomargin shadow">
<form enctype="application/x-www-form-urlencoded" name="EntrezForm" method="post" onsubmit="return false;" action="/medgen" id="EntrezForm">
<div xmlns:xi="http://www.w3.org/2001/XInclude">
<!-- no javascript message -->
<noscript>
<p class="nojs">
<strong>Warning:</strong>
The NCBI web site requires JavaScript to function.
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
</p>
</noscript>
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer/">
<section class="usa-banner">
<div class="usa-accordion">
<header class="usa-banner-header">
<div class="usa-grid usa-banner-inner">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
<p>An official website of the United States government</p>
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
<span class="usa-banner-button-text">Here's how you know</span>
</button>
</div>
</header>
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
<div class="usa-banner-guidance-gov usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
<div class="usa-media_block-body">
<p>
<strong>The .gov means it's official.</strong>
<br />
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you're on a federal
government site.
</p>
</div>
</div>
<div class="usa-banner-guidance-ssl usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
<div class="usa-media_block-body">
<p>
<strong>The site is secure.</strong>
<br />
The <strong>https://</strong> ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
</p>
</div>
</div>
</div>
</div>
</section>
<div class="usa-overlay"></div>
<header class="ncbi-header" role="banner" data-section="Header">
<div class="usa-grid">
<div class="usa-width-one-whole">
<div class="ncbi-header__logo">
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
</a>
</div>
<div class="ncbi-header__account">
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
<span class="fa fa-user" aria-hidden="true">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
<g style="fill: #fff">
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
</g>
</svg>
</span>
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
<span class="sr-only">Show account info</span>
</button>
</div>
<div class="ncbi-popup-anchor">
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
<div class="ncbi-popup-head">
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
<span class="fa fa-times">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
</svg>
</span>
<span class="usa-sr-only">Close</span></button>
<h4>Account</h4>
</div>
<div class="account-user-info">
Logged in as:<br />
<b><span class="username" id="uname_long">username</span></b>
</div>
<div class="account-links">
<ul class="usa-unstyled-list">
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
</ul>
</div>
</div>
</div>
</div>
</div>
</header>
<div role="navigation" aria-label="access keys">
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
</div>
<section data-section="Alerts">
<div class="ncbi-alerts-placeholder"></div>
</section>
</div>
<div class="header">
<!-- logo -->
<div class="res_logo" id="gene-top">
<h1 class="res_name"><a href="/medgen">MedGen</a></h1>
<h2 class="res_tagline">National Center for Biotechnology Information</h2>
</div>
<!-- SearchBar -->
<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="books">Books</option><option value="medgen" selected="selected" data-ac_dict="medgen_disease_name">MedGen</option><option value="clinvar" class="last">ClinVar</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen" data-ac_dict="medgen_disease_name">MedGen</option><option value="mesh" data-ac_dict="mesh_suggestions">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search MedGen. Use up and down arrows to choose an item from the autocomplete." value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'medgen_disease_name',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a sid="1" href="/medgen/limits">Limits</a></li><li><a href="/medgen/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/medgen/docs/help">Help</a></li></ul></div>
</div>
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
<div id="maincontent" class="col nine_col">
<div class="content">
<div>
</div>
<div class="results_settings one_setting"><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display" sid="0" href="#" class="jig-ncbipopper" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu_report', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : false, groupName: 'entrez_pg'" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Display">Full Report<span href="#" class="tgt_dark"></span></a></li></ul><div id="display_settings_menu_report" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="1" value="FullReport" format="" id="FullReport" checked="true" /><label for="FullReport">Full Report</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="2" value="FullReport" format="text" id="FullReporttext" /><label for="FullReporttext">Summary (Text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.sPresentation" sid="3" value="XML" format="text" id="XMLtext" /><label for="XMLtext">Summary (XML)</label></li></ul></fieldset></div><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button" style="display:none">Apply</button><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
jQuery(document).ready( function () {
jQuery("#send_to_menu input[type='radio']").click( function () {
var selectedValue = jQuery(this).val().toLowerCase();
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
if(selectedDiv.is(":hidden")){
jQuery("#send_to_menu div.submenu:visible").slideUp();
selectedDiv.slideDown();
}
});
});
jQuery("#sendto").bind("ncbipopperclose", function(){
jQuery("#send_to_menu div.submenu:visible").css("display","none");
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
});
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendTo" sid="3" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FFormat" sid="1"><option value="FullReport" format="text" selected="selected">Summary (Text)</option><option value="XML" format="text">Summary (XML)</option></select></li></ul><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="2" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.SendToSubmit" sid="3" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.FileFormat" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Presentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.LastFormat" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevPresentation" sid="1" type="hidden" value="FullReport" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_DisplayBar.PrevSort" sid="1" type="hidden" value="" /><input type="hidden" id="coll_startindex" name="CollectionStartIndex" value="1" /></div></div>
<div class="">
<div><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.ResultCount" sid="1" type="hidden" id="resultcount" value="1" /><input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_ResultsController.RunLastQuery" sid="1" type="hidden" /></div>
</div>
<div id="messagearea" class="empty">
</div>
<div><div class="rprt full-rprt"><div class="portlet" style="border-top-style: none; margin-top: 0px; padding-top: 0px; margin-bottom: 0px; padding-left: 0.2em;">
<!--
UID=9283
ConceptID=C0019829
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Classic Hodgkin lymphoma<span class="h1sub">(CHL)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9283</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0019829</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>CHL; Familial Hodgkin Disease; Hodgkin lymphoma</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>HD - Hodgkin's disease (118599009); Malignant Hodgkin's lymphoma (118599009); Hodgkin's disease (clinical) (118599009); Hodgkin's granuloma (clinical) (118602004); Hodgkin's paragranuloma (clinical) (118605002); Hodgkin's disease (118599009); Hodgkin's granuloma (118602004); Hodgkin disease (118599009); Hodgkin granuloma (118602004); Lymphoma, Hodgkins (118599009); Hodgkin granuloma (836277009); Hodgkin's granuloma (836277009); Hodgkin lymphoma (1163005009); Hodgkin's disease (1163005009); Hodgkin's lymphoma (1163005009)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_989040"><div><strong>Unknown inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>989040</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms&#10;that cannot be identified in NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">CN307042</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">Hereditary clinical entity whose mode of inheritance is unknown.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/989040">This record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_989040" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Unknown inheritance</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="KLHDC8B - ID: 200942 - NCBI Gene" href="/gene/200942" class="medgenPMinfo">KLHDC8B</a> (3p21.31)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012189">HP:0012189</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0009348" target="_blank">MONDO:0009348</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/236000" target="_blank">236000</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=391">ORPHA391</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_9283"><div><strong>Classic Hodgkin lymphoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9283</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0019829</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/9283">Feature record</a> | <a href="/medgen?term=%22Classic%20Hodgkin%20lymphoma%22%5BClinical%20Features%5D%20OR%209283%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_871141"><div><strong>Polyclonal elevation of IgM</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871141</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4025612</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/871141">Feature record</a> | <a href="/medgen?term=%22Polyclonal%20elevation%20of%20IgM%22%5BClinical%20Features%5D%20OR%20871141%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_871152"><div><strong>Impaired lymphocyte transformation with phytohemagglutinin</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>871152</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4025625</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/871152">Feature record</a> | <a href="/medgen?term=%22Impaired%20lymphocyte%20transformation%20with%20phytohemagglutinin%22%5BClinical%20Features%5D%20OR%20871152%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(&quot;.TreeLite&quot;,&quot;#ID_102&quot;).TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the immune system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871152" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Impaired lymphocyte transformation with phytohemagglutinin</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_871141" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyclonal elevation of IgM</a></span></li></ul></li><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9283" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Classic Hodgkin lymphoma</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0019829[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=9283">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9283" target="_blank" href="/omim/236000">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=9283" ref="ncbi_uid=9283">V</a></span></span><span class="TLline">Classic Hodgkin lymphoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/235364" ref="tree=MeSH" title="MedGen record for Neoplasm by Special Category">Neoplasm by Special Category</a></span><ul><li><span class="TLline"><a href="/medgen/311033" ref="tree=MeSH" title="MedGen record for Neoplasm by Obsolete Classification">Neoplasm by Obsolete Classification</a></span><ul><li><span class="TLline"><a href="/medgen/268845" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphoid Neoplasm (Antiquated)">Hematopoietic and Lymphoid Neoplasm (Antiquated)</a></span><ul><li><span class="TLline"><a href="/medgen/268867" ref="tree=MeSH" title="MedGen record for Hodgkin Lymphoma (Antiquated)">Hodgkin Lymphoma (Antiquated)</a></span><ul><li><span class="matched_ds">Classic Hodgkin lymphoma</span><ul><li><span class="TLline"><a href="/medgen/67383" ref="tree=MeSH" title="MedGen record for Adult Hodgkin Lymphoma">Adult Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/389532" ref="tree=MeSH" title="MedGen record for Adult Classic Hodgkin Lymphoma">Adult Classic Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/79003" ref="tree=MeSH" title="MedGen record for Adult lymphocyte depleted classical Hodgkin lymphoma">Adult lymphocyte depleted classical Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/231043" ref="tree=MeSH" title="MedGen record for Adult Lymphocyte-Rich Classic Hodgkin Lymphoma">Adult Lymphocyte-Rich Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/83521" ref="tree=MeSH" title="MedGen record for Adult Mixed Cellularity Classic Hodgkin Lymphoma">Adult Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/83520" ref="tree=MeSH" title="MedGen record for Adult Nodular Sclerosis Classic Hodgkin Lymphoma">Adult Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/859697" ref="tree=MeSH" title="MedGen record for Adult Favorable Prognosis Hodgkin Lymphoma">Adult Favorable Prognosis Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1639088" ref="tree=MeSH" title="MedGen record for Adult Hodgkin Lymphoma by Ann Arbor Stage">Adult Hodgkin Lymphoma by Ann Arbor Stage</a></span><ul><li><span class="TLline"><a href="/medgen/78836" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Adult Hodgkin Lymphoma">Ann Arbor Stage I Adult Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/82932" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Adult Hodgkin Lymphoma">Ann Arbor Stage II Adult Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/82933" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Adult Hodgkin Lymphoma">Ann Arbor Stage III Adult Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/124461" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Adult Hodgkin Lymphoma">Ann Arbor Stage IV Adult Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231044" ref="tree=MeSH" title="MedGen record for Adult nodular lymphocyte predominant Hodgkin lymphoma">Adult nodular lymphocyte predominant Hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/859685" ref="tree=MeSH" title="MedGen record for Adult Unfavorable Prognosis Hodgkin Lymphoma">Adult Unfavorable Prognosis Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/852496" ref="tree=MeSH" title="MedGen record for Hodgkin Lymphoma During Pregnancy">Hodgkin Lymphoma During Pregnancy</a></span></li><li><span class="TLline"><a href="/medgen/1637063" ref="tree=MeSH" title="MedGen record for Lugano Classification Adult Hodgkin Lymphoma by AJCC v8 Stage">Lugano Classification Adult Hodgkin Lymphoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1639132" ref="tree=MeSH" title="MedGen record for Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8">Lugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1633194" ref="tree=MeSH" title="MedGen record for Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8">Lugano Classification Limited Stage Adult Hodgkin Lymphoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75833" ref="tree=MeSH" title="MedGen record for Recurrent Adult Hodgkin Lymphoma">Recurrent Adult Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1773787" ref="tree=MeSH" title="MedGen record for Advanced Hodgkin Lymphoma">Advanced Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/389536" ref="tree=MeSH" title="MedGen record for Advanced Favorable Hodgkin Lymphoma">Advanced Favorable Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/384921" ref="tree=MeSH" title="MedGen record for Advanced Unfavorable Hodgkin Lymphoma">Advanced Unfavorable Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/76248" ref="tree=MeSH" title="MedGen record for AIDS-Related Hodgkin Lymphoma">AIDS-Related Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/853574" ref="tree=MeSH" title="MedGen record for Central Nervous System Hodgkin Lymphoma">Central Nervous System Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/272449" ref="tree=MeSH" title="MedGen record for Cerebral Hodgkin Lymphoma">Cerebral Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232052" ref="tree=MeSH" title="MedGen record for Chest Wall Hodgkin Lymphoma">Chest Wall Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/66310" ref="tree=MeSH" title="MedGen record for Childhood Hodgkin Lymphoma">Childhood Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/389537" ref="tree=MeSH" title="MedGen record for Childhood Classic Hodgkin Lymphoma">Childhood Classic Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/124674" ref="tree=MeSH" title="MedGen record for Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma">Childhood Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/272463" ref="tree=MeSH" title="MedGen record for Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma">Childhood Lymphocyte-Rich Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/124675" ref="tree=MeSH" title="MedGen record for Childhood Mixed Cellularity Classic Hodgkin Lymphoma">Childhood Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/76042" ref="tree=MeSH" title="MedGen record for Childhood Nodular Sclerosis Classic Hodgkin Lymphoma">Childhood Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/859257" ref="tree=MeSH" title="MedGen record for Childhood Favorable Prognosis Hodgkin Lymphoma">Childhood Favorable Prognosis Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1647108" ref="tree=MeSH" title="MedGen record for Childhood Hodgkin Lymphoma by Ann Arbor Stage">Childhood Hodgkin Lymphoma by Ann Arbor Stage</a></span><ul><li><span class="TLline"><a href="/medgen/83568" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Childhood Hodgkin Lymphoma">Ann Arbor Stage I Childhood Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/76041" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Childhood Hodgkin Lymphoma">Ann Arbor Stage II Childhood Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/83569" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Childhood Hodgkin Lymphoma">Ann Arbor Stage III Childhood Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/124673" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Childhood Hodgkin Lymphoma">Ann Arbor Stage IV Childhood Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232351" ref="tree=MeSH" title="MedGen record for Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma">Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/859231" ref="tree=MeSH" title="MedGen record for Childhood Unfavorable Prognosis Hodgkin Lymphoma">Childhood Unfavorable Prognosis Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1633818" ref="tree=MeSH" title="MedGen record for Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage">Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1637136" ref="tree=MeSH" title="MedGen record for Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8">Lugano Classification Advanced Stage Childhood Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1637491" ref="tree=MeSH" title="MedGen record for Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8">Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/79050" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Hodgkin Lymphoma">Recurrent Childhood Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/857323" ref="tree=MeSH" title="MedGen record for Refractory Childhood Hodgkin Lymphoma">Refractory Childhood Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/232369" ref="tree=MeSH" title="MedGen record for Classic Hodgkin Lymphoma">Classic Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/224769" ref="tree=MeSH" title="MedGen record for Classic Hodgkin lymphoma, lymphocyte-rich type">Classic Hodgkin lymphoma, lymphocyte-rich type</a></span><ul><li><span class="TLline"><a href="/medgen/1613087" ref="tree=MeSH" title="MedGen record for Recurrent Lymphocyte-Rich Classic Hodgkin Lymphoma">Recurrent Lymphocyte-Rich Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1634873" ref="tree=MeSH" title="MedGen record for Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma">Refractory Lymphocyte-Rich Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/57760" ref="tree=MeSH" title="MedGen record for Hodgkin lymphoma, lymphocyte depletion">Hodgkin lymphoma, lymphocyte depletion</a></span><ul><li><span class="TLline"><a href="/medgen/1640355" ref="tree=MeSH" title="MedGen record for Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage">Lymphocyte-Depleted Classic Hodgkin Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/163464" ref="tree=MeSH" title="MedGen record for Recurrent Lymphocyte-Depleted Classic Hodgkin Lymphoma">Recurrent Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167717" ref="tree=MeSH" title="MedGen record for Refractory Lymphocyte-Depleted Classic Hodgkin Lymphoma">Refractory Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/57521" ref="tree=MeSH" title="MedGen record for Hodgkin lymphoma, mixed cellularity">Hodgkin lymphoma, mixed cellularity</a></span><ul><li><span class="TLline"><a href="/medgen/1645031" ref="tree=MeSH" title="MedGen record for Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage">Mixed Cellularity Classic Hodgkin Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/208948" ref="tree=MeSH" title="MedGen record for Recurrent Mixed Cellularity Classic Hodgkin Lymphoma">Recurrent Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163601" ref="tree=MeSH" title="MedGen record for Refractory Mixed Cellularity Classic Hodgkin Lymphoma">Refractory Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/101830" ref="tree=MeSH" title="MedGen record for Nodular sclerosis classical Hodgkin lymphoma">Nodular sclerosis classical Hodgkin lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/279352" ref="tree=MeSH" title="MedGen record for Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma">Grade 1 Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/90818" ref="tree=MeSH" title="MedGen record for Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma">Grade 2 Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1633374" ref="tree=MeSH" title="MedGen record for Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage">Nodular Sclerosis Classic Hodgkin Lymphoma by Ann Arbor Stage</a></span></li><li><span class="TLline"><a href="/medgen/83177" ref="tree=MeSH" title="MedGen record for Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase">Nodular Sclerosis Classic Hodgkin Lymphoma, Cellular Phase</a></span></li><li><span class="TLline"><a href="/medgen/1714683" ref="tree=MeSH" title="MedGen record for Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant">Nodular Sclerosis Classic Hodgkin Lymphoma, Syncytial Variant</a></span></li><li><span class="TLline"><a href="/medgen/208950" ref="tree=MeSH" title="MedGen record for Recurrent Nodular Sclerosis Classic Hodgkin Lymphoma">Recurrent Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163518" ref="tree=MeSH" title="MedGen record for Refractory Nodular Sclerosis Classic Hodgkin Lymphoma">Refractory Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1626938" ref="tree=MeSH" title="MedGen record for Recurrent Classic Hodgkin Lymphoma">Recurrent Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1617314" ref="tree=MeSH" title="MedGen record for Refractory Classic Hodgkin Lymphoma">Refractory Classic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/272667" ref="tree=MeSH" title="MedGen record for Digestive System Hodgkin Lymphoma">Digestive System Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/474457" ref="tree=MeSH" title="MedGen record for Colorectal Hodgkin Lymphoma">Colorectal Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/232377" ref="tree=MeSH" title="MedGen record for Colon Hodgkin Lymphoma">Colon Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234229" ref="tree=MeSH" title="MedGen record for Esophageal Hodgkin Lymphoma">Esophageal Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/232234" ref="tree=MeSH" title="MedGen record for Gastric Hodgkin Lymphoma">Gastric Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/277652" ref="tree=MeSH" title="MedGen record for Small Intestinal Hodgkin Lymphoma">Small Intestinal Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/234225" ref="tree=MeSH" title="MedGen record for EBV-Related Hodgkin Lymphoma">EBV-Related Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1682426" ref="tree=MeSH" title="MedGen record for Classic Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder">Classic Hodgkin Lymphoma Post-Transplant Lymphoproliferative Disorder</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1647138" ref="tree=MeSH" title="MedGen record for Hodgkin Lymphoma by Ann Arbor Stage">Hodgkin Lymphoma by Ann Arbor Stage</a></span><ul><li><span class="TLline"><a href="/medgen/151815" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Hodgkin Lymphoma">Ann Arbor Stage I Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/234358" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma">Ann Arbor Stage I Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163516" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Mixed Cellularity Classic Hodgkin Lymphoma">Ann Arbor Stage I Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234898" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Nodular Lymphocyte Predominant B-Cell Lymphoma">Ann Arbor Stage I Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167762" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Nodular Sclerosis Classic Hodgkin Lymphoma">Ann Arbor Stage I Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/57801" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Subdiaphragmatic Hodgkin Lymphoma">Ann Arbor Stage I Subdiaphragmatic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234901" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma">Ann Arbor Stage I Supradiaphragmatic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/75498" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IA Hodgkin Lymphoma">Ann Arbor Stage IA Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233481" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IB Hodgkin Lymphoma">Ann Arbor Stage IB Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/146773" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Hodgkin Lymphoma">Ann Arbor Stage II Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/233508" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma">Ann Arbor Stage II Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/236903" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma">Ann Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/236904" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Nodular Lymphocyte Predominant B-Cell Lymphoma">Ann Arbor Stage II Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/277723" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Nodular Sclerosis Classic Hodgkin Lymphoma">Ann Arbor Stage II Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/102290" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Subdiaphragmatic Hodgkin Lymphoma">Ann Arbor Stage II Subdiaphragmatic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/234861" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage II Supradiaphragmatic Hodgkin Lymphoma">Ann Arbor Stage II Supradiaphragmatic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/120465" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IIA Hodgkin Lymphoma">Ann Arbor Stage IIA Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/82646" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IIB Hodgkin Lymphoma">Ann Arbor Stage IIB Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/57802" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Hodgkin Lymphoma">Ann Arbor Stage III Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/57569" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma">Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/57800" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma">Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/277712" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Nodular Lymphocyte Predominant B-Cell Lymphoma">Ann Arbor Stage III Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/57568" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma">Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/82647" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IIIA Hodgkin Lymphoma">Ann Arbor Stage IIIA Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/79367" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IIIB Hodgkin Lymphoma">Ann Arbor Stage IIIB Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/195659" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Hodgkin Lymphoma">Ann Arbor Stage IV Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/167718" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma">Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/163517" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma">Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/236938" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma">Ann Arbor Stage IV Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/167763" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma">Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/79368" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IVA Hodgkin Lymphoma">Ann Arbor Stage IVA Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/277739" ref="tree=MeSH" title="MedGen record for Ann Arbor Stage IVB Hodgkin Lymphoma">Ann Arbor Stage IVB Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1632067" ref="tree=MeSH" title="MedGen record for Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage">Nodular Lymphocyte Predominant B-Cell Lymphoma by Ann Arbor Stage</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/385169" ref="tree=MeSH" title="MedGen record for Hodgkin Lymphoma by Clinical Course">Hodgkin Lymphoma by Clinical Course</a></span><ul><li><span class="TLline"><a href="/medgen/385044" ref="tree=MeSH" title="MedGen record for Favorable Hodgkin Lymphoma">Favorable Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/418026" ref="tree=MeSH" title="MedGen record for Early Favorable Hodgkin Lymphoma">Early Favorable Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/385178" ref="tree=MeSH" title="MedGen record for Unfavorable Hodgkin Lymphoma">Unfavorable Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/378869" ref="tree=MeSH" title="MedGen record for Early Unfavorable Hodgkin Lymphoma">Early Unfavorable Hodgkin Lymphoma</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1644889" ref="tree=MeSH" title="MedGen record for Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage">Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1641672" ref="tree=MeSH" title="MedGen record for Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8">Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1637704" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage III Hodgkin Lymphoma AJCC v8">Lugano Classification Stage III Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1638000" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8">Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1637427" ref="tree=MeSH" title="MedGen record for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8">Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1645987" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage I Hodgkin Lymphoma AJCC v8">Lugano Classification Stage I Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1641597" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8">Lugano Classification Stage IE Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1631920" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage II Hodgkin Lymphoma AJCC v8">Lugano Classification Stage II Hodgkin Lymphoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1644443" ref="tree=MeSH" title="MedGen record for Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8">Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1789531" ref="tree=MeSH" title="MedGen record for Lung Hodgkin Lymphoma">Lung Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233680" ref="tree=MeSH" title="MedGen record for Mediastinal Hodgkin Lymphoma">Mediastinal Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/459101" ref="tree=MeSH" title="MedGen record for Thymic Hodgkin Lymphoma">Thymic Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/233701" ref="tree=MeSH" title="MedGen record for Methotrexate-Associated Hodgkin Lymphoma">Methotrexate-Associated Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233758" ref="tree=MeSH" title="MedGen record for Nodular lymphocyte predominant Hodgkin lymphoma">Nodular lymphocyte predominant Hodgkin lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/277583" ref="tree=MeSH" title="MedGen record for Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma">Recurrent Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/233914" ref="tree=MeSH" title="MedGen record for Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma">Refractory Nodular Lymphocyte Predominant B-Cell Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1738464" ref="tree=MeSH" title="MedGen record for Pharyngeal Hodgkin Lymphoma">Pharyngeal Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/1745206" ref="tree=MeSH" title="MedGen record for Nasopharyngeal Hodgkin Lymphoma">Nasopharyngeal Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1731114" ref="tree=MeSH" title="MedGen record for Oropharyngeal Hodgkin Lymphoma">Oropharyngeal Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1793346" ref="tree=MeSH" title="MedGen record for Primary Bone Hodgkin Lymphoma">Primary Bone Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/232397" ref="tree=MeSH" title="MedGen record for Primary Cutaneous Hodgkin Lymphoma">Primary Cutaneous Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/155431" ref="tree=MeSH" title="MedGen record for Recurrent Hodgkin Lymphoma">Recurrent Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/208949" ref="tree=MeSH" title="MedGen record for Refractory Hodgkin Lymphoma">Refractory Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1760831" ref="tree=MeSH" title="MedGen record for Salivary Gland Hodgkin Lymphoma">Salivary Gland Hodgkin Lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/857243" ref="tree=MeSH" title="MedGen record for Secondary Central Nervous System Hodgkin Lymphoma">Secondary Central Nervous System Hodgkin Lymphoma</a></span><ul><li><span class="TLline"><a href="/medgen/277637" ref="tree=MeSH" title="MedGen record for Secondary Cerebral Hodgkin Lymphoma">Secondary Cerebral Hodgkin Lymphoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/56323" ref="tree=MeSH" title="MedGen record for Splenic hodgkin lymphoma">Splenic hodgkin lymphoma</a></span></li><li><span class="TLline"><a href="/medgen/1789532" ref="tree=MeSH" title="MedGen record for Thyroid Gland Hodgkin Lymphoma">Thyroid Gland Hodgkin Lymphoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_439"><div><strong>Ataxia-telangiectasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>439</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0004135</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The phenotypic spectrum of ataxia-telangiectasia (A-T), a multisystem disorder, is a continuum ranging from classic A-T at the severe end and variant A-T at the milder end. Nonetheless, distinguishing between classic A-T and variant A-T on this spectrum helps understand differences in disease course, rate of progression, and life expectancy. Classic A-T is characterized by childhood onset of progressive neurologic manifestations (initially cerebellar ataxia, followed typically by extrapyramidal involvement and peripheral sensorimotor neuropathy), immunodeficiency (variably associated with abnormalities of humoral immunity, cellular immunity, or combined immune deficiency), pulmonary disease (resulting from recurrent infections, immune deficiency, aspiration, interstitial lung disease, and neurologic abnormalities), and increased risk of malignancy. Although it is generally accepted that intellectual disability is not common in A-T, disturbances in cerebellar as well as non-cerebellar brain areas and networks may result in cognitive deficits. Increased sensitivity to ionizing radiation (x-ray and gamma ray) can result in severe side effects from such treatments. Life expectancy is significantly reduced due to cancer, pulmonary disease, and infections. Variant A-T has a significantly milder disease course. While cerebellar ataxia can be absent, extrapyramidal movement disorders are common (typically dystonia and dystonic tremor) and most individuals have manifestations of axonal sensorimotor polyneuropathy. In contrast to classic A-T, immune function is generally normal, respiratory infections are not increased, and pulmonary disease is not a major feature. However, risk of developing malignancies is increased, particularly in premenopausal females who have an increased risk of developing breast cancer and hematologic malignancies.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/439">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_9283"><div><strong>Classic Hodgkin lymphoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9283</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0019829</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
<div class="spaceAbove">Classic Hodgkin lymphoma is a lymph node cancer of germinal center B-cell origin. Hodgkin lymphoma tumors consist of a minority of malignant cells, known as 'Reed-Sternberg' (RS) cells, mixed with reactive lymphocytes and other benign inflammatory cells. A defining feature of RS cells is the presence of 2 nuclei (summary by Salipante et al., 2009).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/9283">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_216941"><div><strong>Dyskeratosis congenita, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>216941</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1148551</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Dyskeratosis congenita and related telomere biology disorders (DC/TBD) are caused by impaired telomere maintenance resulting in short or very short telomeres. The phenotypic spectrum of telomere biology disorders is broad and includes individuals with classic dyskeratosis congenita (DC) as well as those with very short telomeres and an isolated physical finding. Classic DC is characterized by a triad of dysplastic nails, lacy reticular pigmentation of the upper chest and/or neck, and oral leukoplakia, although this may not be present in all individuals. People with DC/TBD are at increased risk for progressive bone marrow failure (BMF), myelodysplastic syndrome or acute myelogenous leukemia, solid tumors (usually squamous cell carcinoma of the head/neck or anogenital cancer), and pulmonary fibrosis. Other findings can include eye abnormalities (epiphora, blepharitis, sparse eyelashes, ectropion, entropion, trichiasis), taurodontism, liver disease, gastrointestinal telangiectasias, and avascular necrosis of the hips or shoulders. Although most persons with DC/TBD have normal psychomotor development and normal neurologic function, significant developmental delay is present in both forms; additional findings include cerebellar hypoplasia (Hoyeraal Hreidarsson syndrome) and bilateral exudative retinopathy and intracranial calcifications (Revesz syndrome and Coats plus syndrome). Onset and progression of manifestations of DC/TBD vary: at the mild end of the spectrum are those who have only minimal physical findings with normal bone marrow function, and at the severe end are those who have the diagnostic triad and early-onset BMF.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/216941">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_477076"><div><strong>X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477076</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3275445</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">XMEN is an X-linked recessive immunodeficiency characterized by CD4 (186940) lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation (Li et al., 2011). Affected individuals have chronic Epstein-Barr virus (EBV) infection and are susceptible to the development of EBV-associated B-cell lymphoproliferative disorders. Magnesium supplementation may be therapeutic (summary by Li et al., 2014).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/477076">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_765548"><div><strong>Lymphoproliferative syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>765548</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3552634</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lymphoproliferative syndrome-1 is an autosomal recessive primary immunodeficiency characterized by onset in early childhood of Epstein-Barr virus (EBV)-associated immune dysregulation, manifest as lymphoma, lymphomatoid granulomatosis, hemophagocytic lymphohistiocytosis, Hodgkin disease, and/or hypogammaglobulinemia. Autoimmune disorders, such as autoimmune hemolytic anemia or renal disease, may also occur. Patients show a high EBV viral load and decreased invariant natural killer T cells. It is unknown whether patients with ITK mutations are intrinsically susceptible to development of lymphoma or dysgammaglobulinemia in the absence of EBV infection (summary by Stepensky et al., 2011; Linka et al., 2012).&#13; For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/765548">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_766857"><div><strong>Combined immunodeficiency due to STK4 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766857</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3553943</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-110 (IMD110) is an autosomal recessive primary T-cell immunodeficiency syndrome characterized by progressive loss of naive T cells, recurrent bacterial, viral, and fungal infections, warts, and abscesses, and autoimmune manifestations. Patients are at risk for developing lymphoproliferative disorders or lymphoma, particularly associated with EBV. Some patients may show cardiac malformations, including atrial septal defect (Abdollahpour et al., 2012; Nehme et al., 2012).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/766857">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_767454"><div><strong>Lymphoproliferative syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767454</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3554540</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lymphoproliferative syndrome-2, also known as CD27 deficiency, is an autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impairment in specific antibody function resulting from impaired T cell-dependent B-cell responses and T-cell dysfunction (summary by van Montfrans et al., 2012). The phenotype can vary significantly, from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation (summary by Salzer et al., 2013).&#13; For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/767454">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_862808"><div><strong>Immunodeficiency 23</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862808</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4014371</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">IMD23 is an autosomal recessive primary immunodeficiency syndrome characterized by onset of recurrent infections, usually respiratory or cutaneous, in early childhood. Immune workup usually shows neutropenia, lymphopenia, eosinophilia, and increased serum IgE or IgA. Neutrophil chemotactic defects have also been reported. Infectious agents include bacteria, viruses, and fungi. Many patients develop atopic dermatitis, eczema, and other signs of autoinflammation. Affected individuals may also show developmental delay or cognitive impairment of varying severity (summary by Bjorksten and Lundmark, 1976 and Zhang et al., 2014).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/862808">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_863232"><div><strong>STAT3-related early-onset multisystem autoimmune disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863232</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4014795</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Infantile-onset multisystem autoimmune disease-1 is characterized by early childhood onset of a spectrum of autoimmune disorders affecting multiple organs. Common manifestations include insulin-dependent diabetes mellitus and autoimmune enteropathy, or celiac disease, and autoimmune hematologic disorders. Other features include short stature and nonspecific dermatitis. More variable features include hypothyroidism, autoimmune arthritis, and delayed puberty. Some patients may show recurrent infections. The disorder results from an inborn error of cytokine signaling (summary by Flanagan et al., 2014 and Milner et al., 2015).&#13; Genetic Heterogeneity of Infantile-Onset Multisystem Autoimmune Disease&#13; See also ADMIO2 (617006), caused by mutation in the ZAP70 gene (176947) on chromosome 2q12, and ADMIO3 (620430), caused by mutation in the CBLB gene (604491) on chromosome 3q13.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/863232">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1684464"><div><strong>Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684464</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5193036</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">IMAGEI is an autosomal recessive disorder characterized by intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency. Patients exhibit distinctive facial features and variable immune dysfunction with evidence of lymphocyte deficiency (Logan et al., 2018).&#13; An autosomal dominant form of the disorder, without immunodeficiency (IMAGE; 614732), is caused by mutation in the CDKN1C gene (600856) on chromosome 11p15.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1684464">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1784363"><div><strong>Autoinflammatory syndrome with immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1784363</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5543547</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Familial autoinflammatory syndrome with or without immunodeficiency (AISIMD) is characterized by onset of various autoimmune features usually in the first decades of life, although later onset has been reported. Typical features include autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. More variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus (SLE; see 152700). Some patients may have recurrent infections or exacerbation of the disease with acute infection. Laboratory studies show variable findings, often decreased numbers of naive B cells, lymphopenia with skewed subsets, hypogammaglobulinemia, presence of autoantibodies, and a hyperinflammatory state. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Hadjadj et al., 2020).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1784363">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1794280"><div><strong>Immunodeficiency 87 and autoimmunity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794280</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5562070</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-87 and autoimmunity (IMD87) is an autosomal recessive immunologic disorder with wide phenotypic variation and severity. Affected individuals usually present in infancy or early childhood with increased susceptibility to infections, often Epstein-Barr virus (EBV), as well as with lymphadenopathy or autoimmune manifestations, predominantly hemolytic anemia. Laboratory studies may show low or normal lymphocyte numbers, often with skewed T-cell subset ratios. The disorder results primarily from defects in T-cell function, which causes both immunodeficiency and overall immune dysregulation (summary by Serwas et al., 2019 and Fournier et al., 2021).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1794280">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1799982"><div><strong>Severe combined immunodeficiency due to CD70 deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1799982</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5568559</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Lymphoproliferative syndrome-3 (LPFS3) is an autosomal recessive early-onset immunologic disorder characterized by increased susceptibility to Epstein-Barr virus (EBV) infection in B cells, resulting in abnormal B-cell proliferation and increased susceptibility to B-cell malignancies, including Hodgkin lymphoma. Patients usually have hypogammaglobulinemia without lymphopenia, although some subsets of immune cells may be low and some patients may have recurrent infections. The disorder results from impaired signaling from proliferating B cells to effector T cells that provide immune surveillance. There may be an increased risk of solid tumors in heterozygous carriers (summary by Abolhassani et al., 2017).&#13; For a discussion of genetic heterogeneity of lymphoproliferative syndrome, see XLP1 (308240).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1799982">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1840982"><div><strong>Immunodeficiency 109 with lymphoproliferation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1840982</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5830346</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Immunodeficiency-109 with EBV-induced lymphoproliferation (IMD109) is an autosomal recessive primary immune disorder characterized by onset of recurrent sinopulmonary infections in childhood. Affected individuals are susceptible to infection with EBV and develop EBV viremia and EBV-associated lymphoproliferative disease or B-cell lymphoma. Immunologic workup shows normal levels of T, B, and NK cells, with defective CD8+ T cell function after stimulation. Some patients may have hypogammaglobulinemia and poor antibody response to stimulation (Alosaimi et al., 2019).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1840982">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_439" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-telangiectasia syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1784363" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoinflammatory syndrome with immunodeficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9283" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Classic Hodgkin lymphoma</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766857" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined immunodeficiency due to STK4 deficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_216941" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dyskeratosis congenita, X-linked</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (14)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1840982" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 109 with lymphoproliferation</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862808" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 23</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794280" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 87 and autoimmunity</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684464" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_765548" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoproliferative syndrome 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767454" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoproliferative syndrome 2</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1799982" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Severe combined immunodeficiency due to CD70 deficiency</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">STAT3-related early-onset multisystem autoimmune disease</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477076" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia</a></div></span></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38728605">Paradigm Shifts in Hodgkin Lymphoma Treatment: From Frontline Therapies to Relapsed Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Burton C,
Allen P,
Herrera AF</span><br />
<span class="medgenPMjournal">Am Soc Clin Oncol Educ Book</span>
2024 Jun;44(3):e433502.
doi: 10.1200/EDBK_433502.
<span class="bold">PMID: </span><a href="/pubmed/38728605" target="_blank">38728605</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38113419">Spatially Resolved Tumor Microenvironment Predicts Treatment Outcomes in Relapsed/Refractory Hodgkin Lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Aoki T,
Jiang A,
Xu A,
Yin Y,
Gamboa A,
Milne K,
Takata K,
Miyata-Takata T,
Chung S,
Rai S,
Wu S,
Warren M,
Strong C,
Goodyear T,
Morris K,
Chong LC,
Hav M,
Colombo AR,
Telenius A,
Boyle M,
Ben-Neriah S,
Power M,
Gerrie AS,
Weng AP,
Karsan A,
Roth A,
Farinha P,
Scott DW,
Savage KJ,
Nelson BH,
Merchant A,
Steidl C</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2024 Mar 20;42(9):1077-1087.
Epub 2023 Dec 19
doi: 10.1200/JCO.23.01115.
<span class="bold">PMID: </span><a href="/pubmed/38113419" target="_blank">38113419</a><a href="/pmc/articles/PMC10950131" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32451144">Lymphomas of the Mediastinum and Their Differential Diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang ML,
Sohani AR</span><br />
<span class="medgenPMjournal">Semin Diagn Pathol</span>
2020 Jul;37(4):156-165.
Epub 2020 May 15
doi: 10.1053/j.semdp.2020.04.005.
<span class="bold">PMID: </span><a href="/pubmed/32451144" target="_blank">32451144</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22classic%20hodgkin%20lymphoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (39)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/ped_hodgkin.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024</a></h3>
<h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/hodgkins.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Hodgkin Lymphoma, 2024</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/39644065">When should we use it? The role of brentuximab vedotin in 2024.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schroers-Martin JG,
Advani R</span><br />
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
2024 Dec 6;2024(1):511-516.
doi: 10.1182/hematology.2024000668.
<span class="bold">PMID: </span><a href="/pubmed/39644065" target="_blank">39644065</a><a href="/pmc/articles/PMC11665589" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38081297">Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alig SK,
Shahrokh Esfahani M,
Garofalo A,
Li MY,
Rossi C,
Flerlage T,
Flerlage JE,
Adams R,
Binkley MS,
Shukla N,
Jin MC,
Olsen M,
Telenius A,
Mutter JA,
Schroers-Martin JG,
Sworder BJ,
Rai S,
King DA,
Schultz A,
Bögeholz J,
Su S,
Kathuria KR,
Liu CL,
Kang X,
Strohband MJ,
Langfitt D,
Pobre-Piza KF,
Surman S,
Tian F,
Spina V,
Tousseyn T,
Buedts L,
Hoppe R,
Natkunam Y,
Fornecker LM,
Castellino SM,
Advani R,
Rossi D,
Lynch R,
Ghesquières H,
Casasnovas O,
Kurtz DM,
Marks LJ,
Link MP,
André M,
Vandenberghe P,
Steidl C,
Diehn M,
Alizadeh AA</span><br />
<span class="medgenPMjournal">Nature</span>
2024 Jan;625(7996):778-787.
Epub 2023 Dec 11
doi: 10.1038/s41586-023-06903-x.
<span class="bold">PMID: </span><a href="/pubmed/38081297" target="_blank">38081297</a><a href="/pmc/articles/PMC11293530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37983570">Classic Hodgkin Lymphoma in Adolescents and Young Adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kelly KM,
Friedberg JW</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2024 Feb 20;42(6):653-664.
Epub 2023 Nov 20
doi: 10.1200/JCO.23.01799.
<span class="bold">PMID: </span><a href="/pubmed/37983570" target="_blank">37983570</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36564047">Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harker-Murray P,
Mauz-Körholz C,
Leblanc T,
Mascarin M,
Michel G,
Cooper S,
Beishuizen A,
Leger KJ,
Amoroso L,
Buffardi S,
Rigaud C,
Hoppe BS,
Lisano J,
Francis S,
Sacchi M,
Cole PD,
Drachtman RA,
Kelly KM,
Daw S</span><br />
<span class="medgenPMjournal">Blood</span>
2023 Apr 27;141(17):2075-2084.
doi: 10.1182/blood.2022017118.
<span class="bold">PMID: </span><a href="/pubmed/36564047" target="_blank">36564047</a><a href="/pmc/articles/PMC10646780" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36512081">Anti-CD30 antibody-drug conjugate therapy in lymphoma: current knowledge, remaining controversies, and future perspectives.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prince HM,
Hutchings M,
Domingo-Domenech E,
Eichenauer DA,
Advani R</span><br />
<span class="medgenPMjournal">Ann Hematol</span>
2023 Jan;102(1):13-29.
Epub 2022 Dec 13
doi: 10.1007/s00277-022-05054-9.
<span class="bold">PMID: </span><a href="/pubmed/36512081" target="_blank">36512081</a><a href="/pmc/articles/PMC9807535" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (204)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38081297">Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alig SK,
Shahrokh Esfahani M,
Garofalo A,
Li MY,
Rossi C,
Flerlage T,
Flerlage JE,
Adams R,
Binkley MS,
Shukla N,
Jin MC,
Olsen M,
Telenius A,
Mutter JA,
Schroers-Martin JG,
Sworder BJ,
Rai S,
King DA,
Schultz A,
Bögeholz J,
Su S,
Kathuria KR,
Liu CL,
Kang X,
Strohband MJ,
Langfitt D,
Pobre-Piza KF,
Surman S,
Tian F,
Spina V,
Tousseyn T,
Buedts L,
Hoppe R,
Natkunam Y,
Fornecker LM,
Castellino SM,
Advani R,
Rossi D,
Lynch R,
Ghesquières H,
Casasnovas O,
Kurtz DM,
Marks LJ,
Link MP,
André M,
Vandenberghe P,
Steidl C,
Diehn M,
Alizadeh AA</span><br />
<span class="medgenPMjournal">Nature</span>
2024 Jan;625(7996):778-787.
Epub 2023 Dec 11
doi: 10.1038/s41586-023-06903-x.
<span class="bold">PMID: </span><a href="/pubmed/38081297" target="_blank">38081297</a><a href="/pmc/articles/PMC11293530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38037872">Classic Hodgkin lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kahn J,
Dabaja B,
Wu S,
Kelly K,
Berkahn L,
Pavlovsky A,
Sureda A,
LaCasce A</span><br />
<span class="medgenPMjournal">Hematol Oncol</span>
2024 Nov;42(6):e3239.
Epub 2023 Dec 1
doi: 10.1002/hon.3239.
<span class="bold">PMID: </span><a href="/pubmed/38037872" target="_blank">38037872</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34496020">Primary mediastinal large B-cell lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Savage KJ</span><br />
<span class="medgenPMjournal">Blood</span>
2022 Sep 1;140(9):955-970.
doi: 10.1182/blood.2020008376.
<span class="bold">PMID: </span><a href="/pubmed/34496020" target="_blank">34496020</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34117736">How I Diagnose Angioimmunoblastic T-Cell Lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xie Y,
Jaffe ES</span><br />
<span class="medgenPMjournal">Am J Clin Pathol</span>
2021 Jun 17;156(1):1-14.
doi: 10.1093/ajcp/aqab090.
<span class="bold">PMID: </span><a href="/pubmed/34117736" target="_blank">34117736</a><a href="/pmc/articles/PMC8209595" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29751882">Hepatic Lymphoma Diagnosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Choi WT,
Gill RM</span><br />
<span class="medgenPMjournal">Surg Pathol Clin</span>
2018 Jun;11(2):389-402.
Epub 2018 Mar 21
doi: 10.1016/j.path.2018.02.003.
<span class="bold">PMID: </span><a href="/pubmed/29751882" target="_blank">29751882</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (289)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38037872">Classic Hodgkin lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kahn J,
Dabaja B,
Wu S,
Kelly K,
Berkahn L,
Pavlovsky A,
Sureda A,
LaCasce A</span><br />
<span class="medgenPMjournal">Hematol Oncol</span>
2024 Nov;42(6):e3239.
Epub 2023 Dec 1
doi: 10.1002/hon.3239.
<span class="bold">PMID: </span><a href="/pubmed/38037872" target="_blank">38037872</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36512081">Anti-CD30 antibody-drug conjugate therapy in lymphoma: current knowledge, remaining controversies, and future perspectives.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Prince HM,
Hutchings M,
Domingo-Domenech E,
Eichenauer DA,
Advani R</span><br />
<span class="medgenPMjournal">Ann Hematol</span>
2023 Jan;102(1):13-29.
Epub 2022 Dec 13
doi: 10.1007/s00277-022-05054-9.
<span class="bold">PMID: </span><a href="/pubmed/36512081" target="_blank">36512081</a><a href="/pmc/articles/PMC9807535" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36341428">Managing the TME to improve the efficacy of cancer therapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bilotta MT,
Antignani A,
Fitzgerald DJ</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:954992.
Epub 2022 Oct 20
doi: 10.3389/fimmu.2022.954992.
<span class="bold">PMID: </span><a href="/pubmed/36341428" target="_blank">36341428</a><a href="/pmc/articles/PMC9630343" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34496020">Primary mediastinal large B-cell lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Savage KJ</span><br />
<span class="medgenPMjournal">Blood</span>
2022 Sep 1;140(9):955-970.
doi: 10.1182/blood.2020008376.
<span class="bold">PMID: </span><a href="/pubmed/34496020" target="_blank">34496020</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34324483">Mexican consensus on Hodgkin's lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Álvarez-Vera JL,
Aguilar-Luevano J,
Alcívar-Cedeño LM,
Arana-Luna LL,
Arteaga-Ortiz L,
Báez-Islas PE,
Carolina-Reynoso A,
Cesarman-Maus G,
Peña-Celaya JA,
Espitia-Ríos ME,
Fermín-Caminero DJ,
Flores-Patricio W,
García-Camacho AS,
Guzmán-Mora PG,
Hernández-Colín AK,
Hernández-Ruiz E,
Herrera-Olivares W,
Jacobo-Medrano E,
Loera-Fragoso SJ,
Macías-Flores JP,
Martínez-Ramírez MA,
Medina-Guzmán L,
Milán-Salvatierra AI,
Montoya-Jiménez L,
Morales-Adrián JJ,
Mujica-Martínez A,
Nava-Villegas L,
Orellana-Garibay JJ,
Palma-Moreno OG,
Pérez-Zúñiga JM,
Pérez-Gómez KD,
Pichardo-Cepín YM,
Rojas-Castillejos F,
Romero-Martínez E,
Romero-Rodelo H,
Segura-García A,
Silva-Vera K,
Tapía-Enríquez AL,
Teomitzi-Sánchez Ó,
Tepepa-Flores F,
Vilchis-González SP,
Villela-Peña A,
Guerra-Alarcón LV,
Reséndiz-Olea R,
Banda-García L,
Paredes-Lozano EP,
Alvarado-Ibarra M</span><br />
<span class="medgenPMjournal">Gac Med Mex</span>
2021;157(Suppl 2):S1-S16.
doi: 10.24875/GMM.M21000534.
<span class="bold">PMID: </span><a href="/pubmed/34324483" target="_blank">34324483</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (193)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38081297">Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alig SK,
Shahrokh Esfahani M,
Garofalo A,
Li MY,
Rossi C,
Flerlage T,
Flerlage JE,
Adams R,
Binkley MS,
Shukla N,
Jin MC,
Olsen M,
Telenius A,
Mutter JA,
Schroers-Martin JG,
Sworder BJ,
Rai S,
King DA,
Schultz A,
Bögeholz J,
Su S,
Kathuria KR,
Liu CL,
Kang X,
Strohband MJ,
Langfitt D,
Pobre-Piza KF,
Surman S,
Tian F,
Spina V,
Tousseyn T,
Buedts L,
Hoppe R,
Natkunam Y,
Fornecker LM,
Castellino SM,
Advani R,
Rossi D,
Lynch R,
Ghesquières H,
Casasnovas O,
Kurtz DM,
Marks LJ,
Link MP,
André M,
Vandenberghe P,
Steidl C,
Diehn M,
Alizadeh AA</span><br />
<span class="medgenPMjournal">Nature</span>
2024 Jan;625(7996):778-787.
Epub 2023 Dec 11
doi: 10.1038/s41586-023-06903-x.
<span class="bold">PMID: </span><a href="/pubmed/38081297" target="_blank">38081297</a><a href="/pmc/articles/PMC11293530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34324483">Mexican consensus on Hodgkin's lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Álvarez-Vera JL,
Aguilar-Luevano J,
Alcívar-Cedeño LM,
Arana-Luna LL,
Arteaga-Ortiz L,
Báez-Islas PE,
Carolina-Reynoso A,
Cesarman-Maus G,
Peña-Celaya JA,
Espitia-Ríos ME,
Fermín-Caminero DJ,
Flores-Patricio W,
García-Camacho AS,
Guzmán-Mora PG,
Hernández-Colín AK,
Hernández-Ruiz E,
Herrera-Olivares W,
Jacobo-Medrano E,
Loera-Fragoso SJ,
Macías-Flores JP,
Martínez-Ramírez MA,
Medina-Guzmán L,
Milán-Salvatierra AI,
Montoya-Jiménez L,
Morales-Adrián JJ,
Mujica-Martínez A,
Nava-Villegas L,
Orellana-Garibay JJ,
Palma-Moreno OG,
Pérez-Zúñiga JM,
Pérez-Gómez KD,
Pichardo-Cepín YM,
Rojas-Castillejos F,
Romero-Martínez E,
Romero-Rodelo H,
Segura-García A,
Silva-Vera K,
Tapía-Enríquez AL,
Teomitzi-Sánchez Ó,
Tepepa-Flores F,
Vilchis-González SP,
Villela-Peña A,
Guerra-Alarcón LV,
Reséndiz-Olea R,
Banda-García L,
Paredes-Lozano EP,
Alvarado-Ibarra M</span><br />
<span class="medgenPMjournal">Gac Med Mex</span>
2021;157(Suppl 2):S1-S16.
doi: 10.24875/GMM.M21000534.
<span class="bold">PMID: </span><a href="/pubmed/34324483" target="_blank">34324483</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31409671">Pembrolizumab in relapsed or refractory Hodgkin lymphoma: 2-year follow-up of KEYNOTE-087.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chen R,
Zinzani PL,
Lee HJ,
Armand P,
Johnson NA,
Brice P,
Radford J,
Ribrag V,
Molin D,
Vassilakopoulos TP,
Tomita A,
von Tresckow B,
Shipp MA,
Lin J,
Kim E,
Nahar A,
Balakumaran A,
Moskowitz CH</span><br />
<span class="medgenPMjournal">Blood</span>
2019 Oct 3;134(14):1144-1153.
Epub 2019 Aug 13
doi: 10.1182/blood.2019000324.
<span class="bold">PMID: </span><a href="/pubmed/31409671" target="_blank">31409671</a><a href="/pmc/articles/PMC6776792" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30948348">Immunotherapy in Hodgkin Lymphoma: The Road Ahead.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ansell SM</span><br />
<span class="medgenPMjournal">Trends Immunol</span>
2019 May;40(5):380-386.
Epub 2019 Apr 2
doi: 10.1016/j.it.2019.03.003.
<span class="bold">PMID: </span><a href="/pubmed/30948348" target="_blank">30948348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29584546">Nivolumab for Relapsed/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Armand P,
Engert A,
Younes A,
Fanale M,
Santoro A,
Zinzani PL,
Timmerman JM,
Collins GP,
Ramchandren R,
Cohen JB,
De Boer JP,
Kuruvilla J,
Savage KJ,
Trneny M,
Shipp MA,
Kato K,
Sumbul A,
Farsaci B,
Ansell SM</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2018 May 10;36(14):1428-1439.
Epub 2018 Mar 27
doi: 10.1200/JCO.2017.76.0793.
<span class="bold">PMID: </span><a href="/pubmed/29584546" target="_blank">29584546</a><a href="/pmc/articles/PMC6075855" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (192)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38081297">Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Alig SK,
Shahrokh Esfahani M,
Garofalo A,
Li MY,
Rossi C,
Flerlage T,
Flerlage JE,
Adams R,
Binkley MS,
Shukla N,
Jin MC,
Olsen M,
Telenius A,
Mutter JA,
Schroers-Martin JG,
Sworder BJ,
Rai S,
King DA,
Schultz A,
Bögeholz J,
Su S,
Kathuria KR,
Liu CL,
Kang X,
Strohband MJ,
Langfitt D,
Pobre-Piza KF,
Surman S,
Tian F,
Spina V,
Tousseyn T,
Buedts L,
Hoppe R,
Natkunam Y,
Fornecker LM,
Castellino SM,
Advani R,
Rossi D,
Lynch R,
Ghesquières H,
Casasnovas O,
Kurtz DM,
Marks LJ,
Link MP,
André M,
Vandenberghe P,
Steidl C,
Diehn M,
Alizadeh AA</span><br />
<span class="medgenPMjournal">Nature</span>
2024 Jan;625(7996):778-787.
Epub 2023 Dec 11
doi: 10.1038/s41586-023-06903-x.
<span class="bold">PMID: </span><a href="/pubmed/38081297" target="_blank">38081297</a><a href="/pmc/articles/PMC11293530" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36913694">Concurrent pembrolizumab with AVD for untreated classic Hodgkin lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch RC,
Ujjani CS,
Poh C,
Warren EH,
Smith SD,
Shadman M,
Till B,
Raghunathan VM,
Alig S,
Alizadeh AA,
Gulhane A,
Chen DL,
Tseng Y,
Coye H,
Shelby M,
Ottemiller S,
Keo S,
Verni K,
Du H,
Vandermeer J,
Gaston A,
Rasmussen H,
Martin P,
Marzbani E,
Voutsinas J,
Gopal AK</span><br />
<span class="medgenPMjournal">Blood</span>
2023 May 25;141(21):2576-2586.
doi: 10.1182/blood.2022019254.
<span class="bold">PMID: </span><a href="/pubmed/36913694" target="_blank">36913694</a><a href="/pmc/articles/PMC10273164" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36758207">Spatial and molecular profiling of the mononuclear phagocyte network in classic Hodgkin lymphoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Stewart BJ,
Fergie M,
Young MD,
Jones C,
Sachdeva A,
Blain A,
Bacon CM,
Rand V,
Ferdinand JR,
James KR,
Mahbubani KT,
Hook L,
Jonas N,
Coleman N,
Saeb-Parsy K,
Collin M,
Clatworthy MR,
Behjati S,
Carey CD</span><br />
<span class="medgenPMjournal">Blood</span>
2023 May 11;141(19):2343-2358.
doi: 10.1182/blood.2022015575.
<span class="bold">PMID: </span><a href="/pubmed/36758207" target="_blank">36758207</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36564047">Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Harker-Murray P,
Mauz-Körholz C,
Leblanc T,
Mascarin M,
Michel G,
Cooper S,
Beishuizen A,
Leger KJ,
Amoroso L,
Buffardi S,
Rigaud C,
Hoppe BS,
Lisano J,
Francis S,
Sacchi M,
Cole PD,
Drachtman RA,
Kelly KM,
Daw S</span><br />
<span class="medgenPMjournal">Blood</span>
2023 Apr 27;141(17):2075-2084.
doi: 10.1182/blood.2022017118.
<span class="bold">PMID: </span><a href="/pubmed/36564047" target="_blank">36564047</a><a href="/pmc/articles/PMC10646780" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30948348">Immunotherapy in Hodgkin Lymphoma: The Road Ahead.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ansell SM</span><br />
<span class="medgenPMjournal">Trends Immunol</span>
2019 May;40(5):380-386.
Epub 2019 Apr 2
doi: 10.1016/j.it.2019.03.003.
<span class="bold">PMID: </span><a href="/pubmed/30948348" target="_blank">30948348</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (165)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/39806291">Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Meng F,
Xiang M,
Liu Y,
Zeng D</span><br />
<span class="medgenPMjournal">BMC Cancer</span>
2025 Jan 14;25(1):78.
doi: 10.1186/s12885-024-13400-5.
<span class="bold">PMID: </span><a href="/pubmed/39806291" target="_blank">39806291</a><a href="/pmc/articles/PMC11731380" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38896122">HLH and Recurrent EBV Lymphoma as the presenting manifestation of MAGT1 Deficiency: A Systematic Review of the Expanding Disease Spectrum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Golloshi K,
Mitchell W,
Kumar D,
Malik S,
Parikh S,
Aljudi AA,
Castellino SM,
Chandrakasan S</span><br />
<span class="medgenPMjournal">J Clin Immunol</span>
2024 Jun 19;44(7):153.
doi: 10.1007/s10875-024-01749-y.
<span class="bold">PMID: </span><a href="/pubmed/38896122" target="_blank">38896122</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37428199">Paraneoplastic syndromes associated with classic Hodgkin lymphoma, a systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">El Fakih R,
Bajuaifer YS,
Shah AY,
Sulaiman R,
Almohamady R,
ELGohary G,
Alothaimeen HS,
Aljurf M</span><br />
<span class="medgenPMjournal">Ann Hematol</span>
2024 Apr;103(4):1131-1137.
Epub 2023 Jul 10
doi: 10.1007/s00277-023-05357-5.
<span class="bold">PMID: </span><a href="/pubmed/37428199" target="_blank">37428199</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32473554">Complexities in the diagnosis of large B-cell lymphomas, classic Hodgkin lymphomas and overlapping peripheral T-cell lymphomas simplified: An evidence-based guide.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wen KW,
Fakhri B,
Menke J,
Ruiz-Cordero R,
Gill RM,
Ohgami RS</span><br />
<span class="medgenPMjournal">Ann Diagn Pathol</span>
2020 Jun;46:151534.
Epub 2020 May 15
doi: 10.1016/j.anndiagpath.2020.151534.
<span class="bold">PMID: </span><a href="/pubmed/32473554" target="_blank">32473554</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Classic%20Hodgkin%20lymphoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
</div>
</div></div></div></div></div></div></div>
<div id="messagearea_bottom">
</div>
<div class=" bottom">
</div>
</div>
</div>
<div class="supplemental col three_col last">
<h2 class="offscreen_noflow">Supplemental Content</h2>
<div>
<!-- MedGen supplemental column starts here -->
<div class="rightCol mgCol">
<div class="portlet mgSection" id="ID_113">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
</div>
<div class="portlet mgSection" id="ID_106">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
<li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
<li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A3%5F23" target="_blank">FISH-interphase (7)</a></li>
<li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A3%5F32" target="_blank">Karyotyping (2)</a></li>
<li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
<li><a href="/gtr/tests?term=C0019829%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (6)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0019829%5bDISCUI%5d" target="_blank">See all (21)</a></total></li>
</ul></div>
</div>
<div class="portlet mgSection" id="ID_119">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=236000" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=391" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Classic%20Hodgkin%20lymphoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_121">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22classic%20hodgkin%20lymphoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Classic%20Hodgkin%20lymphoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/ped_hodgkin.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Hodgkin Lymphoma, 2024</div></li><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/hodgkins.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Hodgkin Lymphoma, 2024</div></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_115">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&amp;start=1&amp;limit=10&amp;sort=score%20desc&amp;field=number&amp;search=613169" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=200942[geneid]" target="_blank">View KLHDC8B variations in ClinVar</a></li><li><a href="/nuccore/306922360" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=236000" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
</div>
<div class="portlet mgSection" id="ID_116">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Hodgkin+lymphoma/3444" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/lymphoma_hodgkin_classic" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Classic%20Hodgkin%20lymphoma" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/16529/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
</div>
</div>
<div class="portlet brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Reviews</h3>
</div>
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
</div>
<div class="portlet_content">
<ul>
<li>
<a href="/pubmed/clinical?term=Classic%20Hodgkin%20lymphoma" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=1&amp;linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
</li>
<li>
<a href="/pubmed?term=Classic%20Hodgkin%20lymphoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&amp;discoId=gtr_reviews&amp;linkpos=2&amp;linkpostotal=2" target="_blank">Reviews in PubMed</a>
</li>
</ul>
</div>
</div>
<!-- MedGen supplemental column ends here -->
<div class="portlet brieflink">
<div class="portlet_head">
<div class="portlet_title">
<h3>Related information</h3>
</div>
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
</div>
<div class="portlet_content DiscoveryDbLinks">
<ul>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=9283" ref="log$=recordlinks">ClinVar</a>
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&amp;from_uid=9283" ref="log$=recordlinks">Gene</a>
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0019829[DISCUI]" ref="log$=recordlinks">GTR</a>
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0019829[DISCUI]&amp;test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&amp;from_uid=9283" ref="log$=recordlinks">MeSH</a>
<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&amp;from_uid=9283" ref="log$=recordlinks">OMIM</a>
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&amp;from_uid=9283" ref="log$=recordlinks">OMIM(Genes)</a>
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&amp;from_uid=9283" ref="log$=recordlinks">PMC Articles</a>
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&amp;from_uid=9283" ref="log$=recordlinks">PubMed</a>
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
</li>
<li class="brieflinkpopper">
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&amp;from_uid=9283" ref="log$=recordlinks">PubMed (OMIM)</a>
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
</li>
</ul>
</div>
</div>
<div class="portlet">
<div class="portlet_head">
<div class="portlet_title">
<h3>Recent activity</h3>
</div>
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
</div>
<div class="portlet_content">
<div id="HTDisplay" class="">
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
<div class="action">
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
Clear
</a>
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn Off
</a>
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
Turn On
</a>
</div>
<ul id="activity">
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d300eb2f30673f7b5215b1">Classic Hodgkin lymphoma</a>
<div class="ralinkpop offscreen_noflow">Classic Hodgkin lymphoma<div class="brieflinkpopdesc"></div></div>
<div class="tertiary">MedGen</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d300d9cde49f3df731208d">Ataxia-Telangiectasia - GeneReviews®</a>
<div class="ralinkpop offscreen_noflow">Ataxia-Telangiectasia - GeneReviews®<div class="brieflinkpopdesc"></div></div>
<div class="tertiary"></div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d300d867c23b31e01990dd">Table B. [OMIM Entries for Ataxia-Telangiectasia (View All in OMIM)]. - GeneRevi...</a>
<div class="ralinkpop offscreen_noflow">Table B. [OMIM Entries for Ataxia-Telangiectasia (View All in OMIM)]. - GeneReviews®<div class="brieflinkpopdesc"></div></div>
<div class="tertiary"></div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d300c52f30673f7b510422">RecName: Full=Serine-protein kinase ATM; AltName: Full=Ataxia telangiectasia mut...</a>
<div class="ralinkpop offscreen_noflow">RecName: Full=Serine-protein kinase ATM; AltName: Full=Ataxia telangiectasia mutated; Short=A-T mutated<div class="brieflinkpopdesc">gi|575773389|sp|Q13315.4|ATM_HUMAN</div></div>
<div class="tertiary">Protein</div>
</li>
<li class="ra_rcd ralinkpopper two_line">
<a class="htb ralinkpopperctrl" ref="log$=activity&amp;linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67d3008967c23b31e0175fc1">Ataxia-telangiectasia syndrome</a>
<div class="ralinkpop offscreen_noflow">Ataxia-telangiectasia syndrome<div class="brieflinkpopdesc"></div></div>
<div class="tertiary">MedGen</div>
</li>
</ul>
<p class="HTOn">Your browsing activity is empty.</p>
<p class="HTOff">Activity recording is turned off.</p>
<p id="turnOn" class="HTOff">
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&amp;" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
</p>
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
</div>
</div>
</div>
</div>
</div>
<div id="NCBIFooter_dynamic">
<!--<component id="NCBIBreadcrumbs"/>
<component id="NCBIHelpDesk"/>-->
<noscript><img alt="" src="/stat?jsdisabled=true&amp;ncbi_app=entrez&amp;ncbi_db=medgen&amp;ncbi_pdid=FullReport&amp;ncbi_phid=CE8C83B97D2FE1810000000000420031" /></noscript>
</div>
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer/">
<section class="icon-section">
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
<div class="grid-container container">
<div class="icon-section_container">
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
<title>Twitter</title>
<g id="twitterx1008">
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
</g>
</svg>
</a>
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>Facebook</title>
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>LinkedIn</title>
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11,
.cls-12 {
fill: #737373;
}
.cls-11 {
fill-rule: evenodd;
}
</style>
</defs>
<title>GitHub</title>
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
</path>
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
</path>
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
</path>
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
</path>
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
</path>
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
</path>
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
</svg></a>
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
<defs><style>.cls-1{fill:#737373;}</style></defs>
<title>NCBI Insights Blog</title>
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
</svg>
</a>
</div>
</div>
</section>
<section class="container-fluid bg-primary">
<div class="container pt-5">
<div class="row mt-3">
<div class="col-lg-3 col-12">
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
<ul class="list-inline social_media">
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Twitter</title>
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
</g>
<defs>
<clipPath id="clip0_65276_3946">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Facebook</title>
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
</g>
<defs>
<clipPath id="clip0_1717_1086">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Youtube</title>
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
</g>
<defs>
<clipPath id="clip0_1717_1101">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
</ul>
</div>
<div class="col-lg-3 col-12">
<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
</div>
</div>
<div><input name="EntrezSystem2.PEntrez.DbConnector.Db" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.LastDb" sid="1" type="hidden" value="medgen" /><input name="EntrezSystem2.PEntrez.DbConnector.Term" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastTabCmd" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastQueryKey" sid="1" type="hidden" value="4040" /><input name="EntrezSystem2.PEntrez.DbConnector.IdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkReadableName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkSrcDb" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.Cmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.TabCmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.QueryKey" sid="1" type="hidden" /></div>
<input type="hidden" name="p$a" id="p$a" /><input type="hidden" name="p$l" id="p$l" value="EntrezSystem2" /><input type="hidden" name="p$st" id="p$st" value="medgen" /><input name="SessionId" id="SessionId" value="CE8B5AF87C7FFCB1_0191SID" disabled="disabled" type="hidden" /><input name="Snapshot" id="Snapshot" value="/projects/Phenotype/MedGen/MedGen@6.14" disabled="disabled" type="hidden" /></form>
</div>
</div>
<!-- CE8B5AF87C7FFCB1_0191SID /projects/Phenotype/MedGen/MedGen@6.14 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
<script type='text/javascript' src='/portal/js/portal.js'></script><script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/js/4221766/3812534/4212053/3812535/3781605/4186313/2499590/3758627/4078478/3908752/3423/4018706/3891418/4212356/4078480/4078479/4025341/4076482/31971/35962/2733373/33966/3397055/4001808.js" snapshot="medgen"></script></body>
</html>
Reference in a new issue View git blame Copy permalink