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<!--
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UID=893008
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ConceptID=C4072890
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating luteinizing hormone level</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>893008</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4072890</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
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<td>Decreased circulating luteinising hormone level</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030344">HP:0030344</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">A reduction in the circulating level of luteinizing hormone (LH). [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating luteinizing hormone level</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/871176" ref="tree=MeSH" title="MedGen record for Abnormal circulating hormone concentration">Abnormal circulating hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/892748" ref="tree=MeSH" title="MedGen record for Abnormal circulating gonadotropin concentration">Abnormal circulating gonadotropin concentration</a></span><ul><li><span class="TLline"><a href="/medgen/663319" ref="tree=MeSH" title="MedGen record for Abnormal circulating luteinizing hormone concentration">Abnormal circulating luteinizing hormone concentration</a></span><ul><li><span class="matched_ds">Decreased circulating luteinizing hormone level</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_82881"><div><strong>Isolated lutropin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82881</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271582</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Male patients with hypogonadotropic hypogonadism due to isolated luteinizing hormone (LH) deficiency have normal sexual differentiation but fail to develop spontaneous puberty. Absence of LH alters Leydig cell proliferation and maturation and impairs the onset of normal spermatogenesis, which requires high levels of intratesticular testosterone. Infertility and very low levels of spermatogenesis generally persist in affected men despite long-term exposure to gonadotropin therapy. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea (summary by Basciani et al., 2012). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a general phenotypic description and discussion of genetic heterogeneity of hypogonadotropic hypogonadism, see 147950. Reviews Arnhold et al. (2009) noted that the clinical manifestations of female patients with hypogonadotropic hypogonadism due to mutations in LHB are very similar to those of women with hypergonadotropic hypogonadism due to inactivating mutations of the LH receptor (see 238320): all have female external genitalia, spontaneous development of normal pubic hair and breasts at puberty, and normal to late menarche followed by oligoamenorrhea and infertility. Pelvic ultrasound shows a small or normal uterus and normal or enlarged ovaries with cysts. However, women with LHB mutations can be treated with luteinizing hormone or chorionic gonadotropin (CG; 118860) replacement therapy; women with LH receptor mutations are resistant to LH, and no treatment is effective in recovering their fertility.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82881">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_209236"><div><strong>Pituitary hormone deficiency, combined, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>209236</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0878683</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PROP1-related combined pituitary hormone deficiency (CPHD) is associated with deficiencies of: growth hormone (GH); thyroid-stimulating hormone (TSH); the two gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH); prolactin (PrL); and occasionally adrenocorticotropic hormone (ACTH). At birth, in contrast to individuals with congenital CPHD of other etiologies, neonates with PROP1-related CPHD lack perinatal signs of hypopituitarism. Mean birth weights and lengths are usually within the normal range and neonatal hypoglycemia and prolonged neonatal jaundice are not prevalent findings. Most affected individuals are ascertained because of short stature during childhood. Although TSH deficiency can present shortly after birth, TSH deficiency usually occurs with or after the onset of GH deficiency. Hypothyroidism is usually mild. FSH and LH deficiencies are typically identified at the age of onset of puberty. Affected individuals can have absent or delayed and incomplete secondary sexual development with infertility. Untreated males usually have a small penis and small testes. Some females experience menarche but subsequently require hormone replacement therapy. ACTH deficiency is less common and, when present, usually occurs in adolescence or adulthood. Neuroimaging of hypothalamic-pituitary region usually demonstrates a hypoplastic or normal anterior pituitary lobe and a normal posterior pituitary lobe.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/209236">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_295872"><div><strong>Hypogonadotropic hypogonadism 1 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>295872</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563719</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/295872">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333437"><div><strong>Kallmann syndrome with spastic paraplegia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333437</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1839911</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333437">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347798"><div><strong>Ataxia-hypogonadism-choroidal dystrophy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347798</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859093</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PNPLA6 disorders span a phenotypic continuum characterized by variable combinations of cerebellar ataxia; upper motor neuron involvement manifesting as spasticity and/or brisk reflexes; chorioretinal dystrophy associated with variable degrees of reduced visual function; and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). The hypogonadotropic hypogonadism occurs either in isolation or as part of anterior hypopituitarism (growth hormone, thyroid hormone, or gonadotropin deficiencies). Common but less frequent features are peripheral neuropathy (usually of axonal type manifesting as reduced distal reflexes, diminished vibratory sensation, and/or distal muscle wasting); hair anomalies (long eyelashes, bushy eyebrows, or scalp alopecia); short stature; and impaired cognitive functioning (learning disabilities in children; deficits in attention, visuospatial abilities, and recall in adults). Some of these features can occur in distinct clusters on the phenotypic continuum: Boucher-Neuhäuser syndrome (cerebellar ataxia, chorioretinal dystrophy, and hypogonadotropic hypogonadism); Gordon Holmes syndrome (cerebellar ataxia, hypogonadotropic hypogonadism, and – to a variable degree – brisk reflexes); Oliver-McFarlane syndrome (trichomegaly, chorioretinal dystrophy, short stature, intellectual disability, and hypopituitarism); Laurence-Moon syndrome; and spastic paraplegia type 39 (SPG39) (upper motor neuron involvement, peripheral neuropathy, and sometimes reduced cognitive functioning and/or cerebellar ataxia).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347798">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_348510"><div><strong>Familial adrenal hypoplasia with absent pituitary luteinizing hormone</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348510</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859978</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial adrenal hypoplasia with absent pituitary luteinizing hormone is a rare endocrine disease characterized by a miniature adult type of congenital adrenal hypoplasia (residual adrenal cortex is composed of a small amount of permanent adult cortex with normal structural organization), selective absence of pituitary luteinizing hormone in otherwise normal brain, and neonatal demise. Patients present with hypogonadotropic hypogonadism, hypoglycemia, seizures, encephalopathy and diabetes insipidus. There have been no further descriptions in the literature since 1988.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/348510">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1789612"><div><strong>Delayed puberty, self-limited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1789612</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2874202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Self-limited delayed puberty (DPSL) is characterized by delayed development of Tanner stage G2 accompanied by low serum gonadotropins. Affected individuals experience spontaneous attainment of Tanner stage G4 by 18 years of age, with normalization of gonadotropins, which excludes a diagnosis of hypogonadotropic hypogonadism (see 147950) (Mancini et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1789612">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462790"><div><strong>Pituitary hormone deficiency, combined, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462790</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151440</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any combined pituitary hormone deficiencies, genetic form in which the cause of the disease is a mutation in the OTX2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462790">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_762090"><div><strong>Hypogonadotropic hypogonadism 13 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762090</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3541462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/762090">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766755"><div><strong>Hypogonadotropic hypogonadism 8 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766755</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553841</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766755">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766757"><div><strong>Hypogonadotropic hypogonadism 10 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766757</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553843</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766757">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766935"><div><strong>Hypogonadotropic hypogonadism 16 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766935</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554021</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766935">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863425"><div><strong>Hypogonadotropic hypogonadism 22 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863425</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014988</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863425">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1810165"><div><strong>Hypogonadotropic hypogonadism 27 without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1810165</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676921</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism-27 without anosmia (HH27) is characterized by lack of pubertal development associated with onset of obesity in early adolescence (Topaloglu et al., 2022). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1810165">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1808634"><div><strong>Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1808634</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676924</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism (CDIDHH) is characterized by delayed motor development, ataxia, severe progressive scoliosis, moderate to severe intellectual disability, and delayed sexual development. Cerebellar hypoplasia has been observed in some patients (Whittaker et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1808634">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841011"><div><strong>Pituitary hormone deficiency, combined or isolated, 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841011</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830375</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Combined pituitary hormone deficiency-8 (CPHD8) is an autosomal dominant disorder characterized by deficiency of one or more of the pituitary hormones. Affected individuals have short stature due to growth hormone (GH; 139250) deficiency with variable deficiencies of other pituitary hormones, including TSH (see 188540), ACTH, and LH/FSH (see 118850). Posterior pituitary deficiency leading to central diabetes insipidus is rare (Bashamboo et al., 2017). Many patients are diagnosed with 'pituitary stalk interruption syndrome' (PSIS), which is characterized by a thin or absent pituitary stalk, absent or ectopic posterior pituitary, and hypoplasia of the anterior pituitary demonstrated on brain imaging, although this classic triad may be incomplete. Brauner et al. (2020) noted the complex phenotypic and genetic heterogeneity of PSIS, and concluded that it is a feature of genetic disorders or syndromes rather than a specific clinical entity. For a discussion of genetic heterogeneity of combined pituitary hormone deficiency, see CPHD1 (613038).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841011">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1845412"><div><strong>Diabetes, deafness, developmental delay, and short stature syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1845412</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5882732</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Diabetes, deafness, developmental delay, and short stature syndrome (DDDS) is characterized by childhood-onset autoantibody-negative diabetes mellitus and bilateral sensorineural deafness, as well as short stature, microcephaly, and developmental delay (Montaser et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1845412">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347798" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-hypogonadism-choroidal dystrophy syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1808634" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebellar dysfunction, impaired intellectual development, and hypogonadotropic hypogonadism</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1789612" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed puberty, self-limited</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1845412" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Diabetes, deafness, developmental delay, and short stature syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_348510" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial adrenal hypoplasia with absent pituitary luteinizing hormone</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (17)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_295872" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 1 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766757" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 10 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762090" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 13 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766935" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 16 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863425" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 22 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1810165" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 27 without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766755" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 8 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82881" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Isolated lutropin deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333437" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kallmann syndrome with spastic paraplegia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841011" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined or isolated, 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_209236" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462790" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pituitary hormone deficiency, combined, 6</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/22824092">Luteinizing hormone, sex steroids and extracorporeal circulation - a promising link to treat retroperitoneal sarcomas. A reconsideration of cancer treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lazar AM</span><br />
|
||
<span class="medgenPMjournal">Med Hypotheses</span>
|
||
2012 Oct;79(4):474-7.
|
||
Epub 2012 Jul 21
|
||
doi: 10.1016/j.mehy.2012.06.027.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22824092" target="_blank">22824092</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20110043">Degarelix: a gonadotropin-releasing hormone antagonist for the management of prostate cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Steinberg M</span><br />
|
||
<span class="medgenPMjournal">Clin Ther</span>
|
||
2009;31 Pt 2:2312-31.
|
||
doi: 10.1016/j.clinthera.2009.11.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20110043" target="_blank">20110043</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8875126">In vitro fertilisation. A review of drug therapy and clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jennings JC,
|
||
Moreland K,
|
||
Peterson CM</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
1996 Sep;52(3):313-43.
|
||
doi: 10.2165/00003495-199652030-00002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8875126" target="_blank">8875126</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20luteinizing%20hormone%20level)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (21)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
|
||
Dalla Volta A,
|
||
Palumbo C,
|
||
Zamboni S,
|
||
Triggiani L,
|
||
Zamparini M,
|
||
Laganà M,
|
||
Rinaudo L,
|
||
Di Meo N,
|
||
Caramella I,
|
||
Bresciani R,
|
||
Valcamonico F,
|
||
Borghetti P,
|
||
Guerini A,
|
||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37968377">Prediction of ovulation: new insight into an old challenge.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maman E,
|
||
Adashi EY,
|
||
Baum M,
|
||
Hourvitz A</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2023 Nov 15;13(1):20003.
|
||
doi: 10.1038/s41598-023-47241-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37968377" target="_blank">37968377</a><a href="/pmc/articles/PMC10651856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37639720">Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marriott RJ,
|
||
Murray K,
|
||
Adams RJ,
|
||
Antonio L,
|
||
Ballantyne CM,
|
||
Bauer DC,
|
||
Bhasin S,
|
||
Biggs ML,
|
||
Cawthon PM,
|
||
Couper DJ,
|
||
Dobs AS,
|
||
Flicker L,
|
||
Handelsman DJ,
|
||
Hankey GJ,
|
||
Hannemann A,
|
||
Haring R,
|
||
Hsu B,
|
||
Karlsson M,
|
||
Martin SA,
|
||
Matsumoto AM,
|
||
Mellström D,
|
||
Ohlsson C,
|
||
O'Neill TW,
|
||
Orwoll ES,
|
||
Quartagno M,
|
||
Shores MM,
|
||
Steveling A,
|
||
Tivesten Å,
|
||
Travison TG,
|
||
Vanderschueren D,
|
||
Wittert GA,
|
||
Wu FCW,
|
||
Yeap BB</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2023 Sep;176(9):1221-1234.
|
||
Epub 2023 Aug 29
|
||
doi: 10.7326/M23-0342.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37639720" target="_blank">37639720</a><a href="/pmc/articles/PMC10995451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31658123">Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie SH,
|
||
Ness-Jensen E,
|
||
Rabbani S,
|
||
Langseth H,
|
||
Gislefoss RE,
|
||
Mattsson F,
|
||
Lagergren J</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2020 Feb;115(2):216-223.
|
||
doi: 10.14309/ajg.0000000000000446.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31658123" target="_blank">31658123</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6365947">Stimulation of LH fragments with reduced bioactivity following GnRH agonist administration in women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meldrum DR,
|
||
Tsao Z,
|
||
Monroe SE,
|
||
Braunstein GD,
|
||
Sladek J,
|
||
Lu JK,
|
||
Vale W,
|
||
Rivier J,
|
||
Judd HL,
|
||
Chang RJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
1984 Apr;58(4):755-7.
|
||
doi: 10.1210/jcem-58-4-755.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6365947" target="_blank">6365947</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (163)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37968377">Prediction of ovulation: new insight into an old challenge.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maman E,
|
||
Adashi EY,
|
||
Baum M,
|
||
Hourvitz A</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2023 Nov 15;13(1):20003.
|
||
doi: 10.1038/s41598-023-47241-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37968377" target="_blank">37968377</a><a href="/pmc/articles/PMC10651856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37235781">Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Albrethsen J,
|
||
Østergren PB,
|
||
Norup PB,
|
||
Sønksen J,
|
||
Fode M,
|
||
Kistorp C,
|
||
Nordsborg NB,
|
||
Solheim SA,
|
||
Mørkeberg J,
|
||
Main KM,
|
||
Juul A</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Oct 18;108(11):2834-2839.
|
||
doi: 10.1210/clinem/dgad291.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37235781" target="_blank">37235781</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32895915">Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie SH,
|
||
Ness-Jensen E,
|
||
Langseth H,
|
||
Gislefoss RE,
|
||
Mattsson F,
|
||
Lagergren J</span><br />
|
||
<span class="medgenPMjournal">Int J Cancer</span>
|
||
2021 Feb 15;148(4):905-913.
|
||
Epub 2020 Sep 22
|
||
doi: 10.1002/ijc.33285.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32895915" target="_blank">32895915</a><a href="/pmc/articles/PMC7820945" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2257245">Neuroendocrine regulation of pulsatile luteinizing hormone secretion in elderly men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaufman JM,
|
||
Deslypere JP,
|
||
Giri M,
|
||
Vermeulen A</span><br />
|
||
<span class="medgenPMjournal">J Steroid Biochem Mol Biol</span>
|
||
1990 Nov 20;37(3):421-30.
|
||
doi: 10.1016/0960-0760(90)90493-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2257245" target="_blank">2257245</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6781115">Endocrinology of testicular neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pearson JC</span><br />
|
||
<span class="medgenPMjournal">Urology</span>
|
||
1981 Feb;17(2):119-25.
|
||
doi: 10.1016/0090-4295(81)90217-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6781115" target="_blank">6781115</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (77)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
|
||
Dalla Volta A,
|
||
Palumbo C,
|
||
Zamboni S,
|
||
Triggiani L,
|
||
Zamparini M,
|
||
Laganà M,
|
||
Rinaudo L,
|
||
Di Meo N,
|
||
Caramella I,
|
||
Bresciani R,
|
||
Valcamonico F,
|
||
Borghetti P,
|
||
Guerini A,
|
||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37639720">Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marriott RJ,
|
||
Murray K,
|
||
Adams RJ,
|
||
Antonio L,
|
||
Ballantyne CM,
|
||
Bauer DC,
|
||
Bhasin S,
|
||
Biggs ML,
|
||
Cawthon PM,
|
||
Couper DJ,
|
||
Dobs AS,
|
||
Flicker L,
|
||
Handelsman DJ,
|
||
Hankey GJ,
|
||
Hannemann A,
|
||
Haring R,
|
||
Hsu B,
|
||
Karlsson M,
|
||
Martin SA,
|
||
Matsumoto AM,
|
||
Mellström D,
|
||
Ohlsson C,
|
||
O'Neill TW,
|
||
Orwoll ES,
|
||
Quartagno M,
|
||
Shores MM,
|
||
Steveling A,
|
||
Tivesten Å,
|
||
Travison TG,
|
||
Vanderschueren D,
|
||
Wittert GA,
|
||
Wu FCW,
|
||
Yeap BB</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
2023 Sep;176(9):1221-1234.
|
||
Epub 2023 Aug 29
|
||
doi: 10.7326/M23-0342.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37639720" target="_blank">37639720</a><a href="/pmc/articles/PMC10995451" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37235781">Serum Insulin-like Factor 3, Testosterone, and LH in Experimental and Therapeutic Testicular Suppression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Albrethsen J,
|
||
Østergren PB,
|
||
Norup PB,
|
||
Sønksen J,
|
||
Fode M,
|
||
Kistorp C,
|
||
Nordsborg NB,
|
||
Solheim SA,
|
||
Mørkeberg J,
|
||
Main KM,
|
||
Juul A</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Oct 18;108(11):2834-2839.
|
||
doi: 10.1210/clinem/dgad291.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37235781" target="_blank">37235781</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34000049">Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fraser GL,
|
||
Obermayer-Pietsch B,
|
||
Laven J,
|
||
Griesinger G,
|
||
Pintiaux A,
|
||
Timmerman D,
|
||
Fauser BCJM,
|
||
Lademacher C,
|
||
Combalbert J,
|
||
Hoveyda HR,
|
||
Ramael S</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2021 Aug 18;106(9):e3519-e3532.
|
||
doi: 10.1210/clinem/dgab320.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34000049" target="_blank">34000049</a><a href="/pmc/articles/PMC8372662" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20595939">Glucocorticoids, stress, and fertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Whirledge S,
|
||
Cidlowski JA</span><br />
|
||
<span class="medgenPMjournal">Minerva Endocrinol</span>
|
||
2010 Jun;35(2):109-25.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20595939" target="_blank">20595939</a><a href="/pmc/articles/PMC3547681" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (158)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37968377">Prediction of ovulation: new insight into an old challenge.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Maman E,
|
||
Adashi EY,
|
||
Baum M,
|
||
Hourvitz A</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2023 Nov 15;13(1):20003.
|
||
doi: 10.1038/s41598-023-47241-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37968377" target="_blank">37968377</a><a href="/pmc/articles/PMC10651856" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37422153">Effects of elevated serum estrogen on dry eye in women undergoing in vitro fertilisation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boga A,
|
||
Stapleton F,
|
||
Chapman M,
|
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Golebiowski B</span><br />
|
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<span class="medgenPMjournal">Ocul Surf</span>
|
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2023 Jul;29:511-520.
|
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Epub 2023 Jul 6
|
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doi: 10.1016/j.jtos.2023.06.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37422153" target="_blank">37422153</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32895915">Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie SH,
|
||
Ness-Jensen E,
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||
Langseth H,
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Gislefoss RE,
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Mattsson F,
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<span class="medgenPMjournal">Int J Cancer</span>
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2021 Feb 15;148(4):905-913.
|
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Epub 2020 Sep 22
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|
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<span class="bold">PMID: </span><a href="/pubmed/32895915" target="_blank">32895915</a><a href="/pmc/articles/PMC7820945" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32608281">Subfatin and asprosin, two new metabolic players of polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Deniz R,
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||
Yavuzkir S,
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Ugur K,
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Ustebay DU,
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Baykus Y,
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<span class="medgenPMjournal">J Obstet Gynaecol</span>
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2021 Feb;41(2):279-284.
|
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Epub 2020 Jul 1
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doi: 10.1080/01443615.2020.1758926.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32608281" target="_blank">32608281</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6773821">Prediction and detection of ovulation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moghissi KS</span><br />
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<span class="medgenPMjournal">Fertil Steril</span>
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1980 Aug;34(2):89-98.
|
||
doi: 10.1016/s0015-0282(16)44888-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6773821" target="_blank">6773821</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (41)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38656229">Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bergamini M,
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Dalla Volta A,
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Palumbo C,
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Zamboni S,
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Triggiani L,
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Zamparini M,
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Laganà M,
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Rinaudo L,
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||
Di Meo N,
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Caramella I,
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||
Bresciani R,
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Valcamonico F,
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Borghetti P,
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Guerini A,
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||
Farina D,
|
||
Antonelli A,
|
||
Simeone C,
|
||
Mazziotti G,
|
||
Berruti A</span><br />
|
||
<span class="medgenPMjournal">Elife</span>
|
||
2024 Apr 24;13
|
||
doi: 10.7554/eLife.92655.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38656229" target="_blank">38656229</a><a href="/pmc/articles/PMC11042799" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11108867">Neuroendocrine effects of progesterone.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chabbert-Buffeta N,
|
||
Skinner DC,
|
||
Caraty A,
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||
Bouchard P</span><br />
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||
<span class="medgenPMjournal">Steroids</span>
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||
2000 Oct-Nov;65(10-11):613-20.
|
||
doi: 10.1016/s0039-128x(00)00187-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11108867" target="_blank">11108867</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10571532">Estrogen stimulates neuronal nitric oxide synthase protein expression in human neutrophils.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">García-Durán M,
|
||
de Frutos T,
|
||
Díaz-Recasens J,
|
||
García-Gálvez G,
|
||
Jiménez A,
|
||
Montón M,
|
||
Farré J,
|
||
Sánchez de Miguel L,
|
||
González-Fernández F,
|
||
Arriero MD,
|
||
Rico L,
|
||
García R,
|
||
Casado S,
|
||
López-Farré A</span><br />
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||
<span class="medgenPMjournal">Circ Res</span>
|
||
1999 Nov 26;85(11):1020-6.
|
||
doi: 10.1161/01.res.85.11.1020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10571532" target="_blank">10571532</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2257245">Neuroendocrine regulation of pulsatile luteinizing hormone secretion in elderly men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaufman JM,
|
||
Deslypere JP,
|
||
Giri M,
|
||
Vermeulen A</span><br />
|
||
<span class="medgenPMjournal">J Steroid Biochem Mol Biol</span>
|
||
1990 Nov 20;37(3):421-30.
|
||
doi: 10.1016/0960-0760(90)90493-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2257245" target="_blank">2257245</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6773821">Prediction and detection of ovulation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moghissi KS</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
1980 Aug;34(2):89-98.
|
||
doi: 10.1016/s0015-0282(16)44888-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6773821" target="_blank">6773821</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20luteinizing%20hormone%20level%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (154)</a></div></div>
|
||
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|
||
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|
||
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|
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|
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|
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|
||
|
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|
||
|
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|
||
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|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
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|
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|
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Decreased%20circulating%20luteinizing%20hormone%20level" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d4fc3867c23b31e029f345">Decreased circulating luteinizing hormone level</a>
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<div class="ralinkpop offscreen_noflow">Decreased circulating luteinizing hormone level<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d4fc3667c23b31e029eb8f">Decreased circulating follicle stimulating hormone concentration</a>
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<div class="ralinkpop offscreen_noflow">Decreased circulating follicle stimulating hormone concentration<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d4fc3484f3725e59af9e73">Abnormal circulating adrenocorticotropin concentration</a>
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<div class="ralinkpop offscreen_noflow">Abnormal circulating adrenocorticotropin concentration<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d4fc3167c23b31e029d2e7">Decreased thyroid-stimulating hormone level</a>
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<div class="ralinkpop offscreen_noflow">Decreased thyroid-stimulating hormone level<div class="brieflinkpopdesc"></div></div>
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<div class="tertiary">MedGen</div>
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<div class="ralinkpop offscreen_noflow">Reduced circulating growth hormone concentration<div class="brieflinkpopdesc"></div></div>
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