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<meta name="keywords" content="C4021998, finding, lack of skin elasticity, tight skin, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="" /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Lack of skin elasticity (Concept Id: C4021998)
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<!--
UID=892876
ConceptID=C4021998
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Lack of skin elasticity</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>892876</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4021998</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Tight skin</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100679">HP:0100679</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4021998[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=892876">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Lack of skin elasticity</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871273" ref="tree=MeSH" title="MedGen record for Abnormality of the integument">Abnormality of the integument</a></span><ul><li><span class="TLline"><a href="/medgen/1845238" ref="tree=MeSH" title="MedGen record for Abnormality of the skin">Abnormality of the skin</a></span><ul><li><span class="TLline"><a href="/medgen/869110" ref="tree=MeSH" title="MedGen record for Abnormal skin morphology">Abnormal skin morphology</a></span><ul><li><span class="TLline"><a href="/medgen/869334" ref="tree=MeSH" title="MedGen record for Abnormal elasticity of skin">Abnormal elasticity of skin</a></span><ul><li><span class="matched_ds">Lack of skin elasticity</span><ul><li><span class="TLline"><a href="/medgen/57541" ref="tree=MeSH" title="MedGen record for Striae distensae">Striae distensae</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_358388"><div><strong>Weill-Marchesani syndrome 2, dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>358388</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1869115</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Weill-Marchesani syndrome (WMS) is a connective tissue disorder characterized by abnormalities of the lens of the eye, short stature, brachydactyly, joint stiffness, and cardiovascular defects. The ocular problems, typically recognized in childhood, include microspherophakia (small spherical lens), myopia secondary to the abnormal shape of the lens, ectopia lentis (abnormal position of the lens), and glaucoma, which can lead to blindness. Height of adult males is 142-169 cm; height of adult females is 130-157 cm. Autosomal recessive WMS cannot be distinguished from autosomal dominant WMS by clinical findings alone.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/358388">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_414526"><div><strong>Autosomal recessive cutis laxa type 2B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414526</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2751987</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The phenotype of autosomal recessive cutis laxa type II (ARCL2) includes cutis laxa of variable severity, abnormal growth, developmental delay, and associated skeletal abnormalities (summary by Morava et al., 2009). No specific clinical features distinguish ARCL2A (219200), which includes a glycosylation defect, and ARCL2B, in which abnormal glycosylation has not been reported (Morava et al., 2009; Guernsey et al., 2009).&#13; For a phenotypic description and discussion of genetic heterogeneity of autosomal recessive cutis laxa, see ARCL1A (219100).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/414526">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_479777"><div><strong>Geleophysic dysplasia 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>479777</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3278147</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Geleophysic dysplasia, a progressive condition resembling a lysosomal storage disorder, is characterized by short stature, short hands and feet, progressive joint limitation and contractures, distinctive facial features, progressive cardiac valvular disease, and thickened skin. Intellect is normal. The characteristic clinical findings are likely to be present in the first year of life. Cardiac, airway, and pulmonary involvement result in death before age five years in approximately 33% of individuals.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/479777">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_811623"><div><strong>Mandibular hypoplasia-deafness-progeroid syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811623</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3715192</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL) is an autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, a characteristic facial appearance, and metabolic abnormalities including insulin resistance and diabetes mellitus. Sensorineural deafness occurs late in the first or second decades of life (summary by Weedon et al., 2013).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/811623">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive cutis laxa type 2B</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_479777" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Geleophysic dysplasia 1</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_811623" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mandibular hypoplasia-deafness-progeroid syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_358388" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Weill-Marchesani syndrome 2, dominant</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36399628">Treatment of Facial Flaccidity and Sagging after Botulinum Toxin A Injection into the Masseter.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yin Y,
Li T,
Wang C,
Ma Q,
Fan X</span><br />
<span class="medgenPMjournal">Plast Reconstr Surg</span>
2023 Mar 1;151(3):521-525.
Epub 2022 Nov 19
doi: 10.1097/PRS.0000000000009909.
<span class="bold">PMID: </span><a href="/pubmed/36399628" target="_blank">36399628</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30406640">Rutosides for treatment of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morling JR,
Broderick C,
Yeoh SE,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Nov 8;11(11):CD005625.
doi: 10.1002/14651858.CD005625.pub4.
<span class="bold">PMID: </span><a href="/pubmed/30406640" target="_blank">30406640</a><a href="/pmc/articles/PMC6517027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27623860">Approach to the management of pregnancy in patients with pseudoxanthoma elasticum: a review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Camacho M,
Rengel C,
López-Herrero E,
Carrillo JL,
Eslava AJ,
Valdivielso P</span><br />
<span class="medgenPMjournal">J Obstet Gynaecol</span>
2016 Nov;36(8):1061-1066.
Epub 2016 Sep 13
doi: 10.1080/01443615.2016.1196478.
<span class="bold">PMID: </span><a href="/pubmed/27623860" target="_blank">27623860</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(lack%20of%20skin%20elasticity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (7)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/33853085">Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goh CF,
Mohamed Faisal N,
Ismail FN</span><br />
<span class="medgenPMjournal">Skin Pharmacol Physiol</span>
2021;34(6):351-362.
Epub 2021 Apr 14
doi: 10.1159/000514995.
<span class="bold">PMID: </span><a href="/pubmed/33853085" target="_blank">33853085</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30975064">Application of acellular human dermis and skin grafts for lower extremity reconstruction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim YH,
Hwang KT,
Kim KH,
Sung IH,
Kim SW</span><br />
<span class="medgenPMjournal">J Wound Care</span>
2019 Apr 1;28(Sup4):S12-S17.
doi: 10.12968/jowc.2019.28.Sup4.S12.
<span class="bold">PMID: </span><a href="/pubmed/30975064" target="_blank">30975064</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30406640">Rutosides for treatment of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morling JR,
Broderick C,
Yeoh SE,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Nov 8;11(11):CD005625.
doi: 10.1002/14651858.CD005625.pub4.
<span class="bold">PMID: </span><a href="/pubmed/30406640" target="_blank">30406640</a><a href="/pmc/articles/PMC6517027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28950030">Compression therapy for prevention of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Appelen D,
van Loo E,
Prins MH,
Neumann MH,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Sep 26;9(9):CD004174.
doi: 10.1002/14651858.CD004174.pub3.
<span class="bold">PMID: </span><a href="/pubmed/28950030" target="_blank">28950030</a><a href="/pmc/articles/PMC6483721" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28486967">Pseudoxanthoma elasticum.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Germain DP</span><br />
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
2017 May 10;12(1):85.
doi: 10.1186/s13023-017-0639-8.
<span class="bold">PMID: </span><a href="/pubmed/28486967" target="_blank">28486967</a><a href="/pmc/articles/PMC5424392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (59)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/40035992">Ultrasound Beyond Joints: A Review of Extra-Articular Applications in Rheumatology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">D'Ignazio E,
Corradini D,
Cazenave T,
Bixio R,
Baldi C,
Ubhi HK,
Smith K,
Wakefield RJ,
Emery P,
Di Matteo A</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2025 Mar 4;27(1):20.
doi: 10.1007/s11926-025-01186-9.
<span class="bold">PMID: </span><a href="/pubmed/40035992" target="_blank">40035992</a><a href="/pmc/articles/PMC11880079" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38650128">The therapeutic effects of ADSCs on photoaging of skin induced by UVB irradiation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang J,
Zhou X,
Cao D,
Meng Y,
Wang Y,
Yang D</span><br />
<span class="medgenPMjournal">Cell Mol Biol (Noisy-le-grand)</span>
2024 Mar 31;70(3):233-240.
doi: 10.14715/cmb/2024.70.3.35.
<span class="bold">PMID: </span><a href="/pubmed/38650128" target="_blank">38650128</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37738289">Usefulness of Ultrasound in Verrucous Venous Malformation: a Series of 103 Cases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gong X,
Chang SJ,
Xiong P,
Lin X,
Wang L</span><br />
<span class="medgenPMjournal">Dermatol Surg</span>
2023 Nov 1;49(11):1006-1011.
Epub 2023 Sep 18
doi: 10.1097/DSS.0000000000003922.
<span class="bold">PMID: </span><a href="/pubmed/37738289" target="_blank">37738289</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36521712">Skin-mimicking strategy to fabricate strong and highly conductive anti-freezing cellulose-based hydrogels as strain sensors.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Xie Y,
Gao S,
Jian J,
Shi X,
Lai C,
Wang C,
Xu F,
Chu F,
Zhang D</span><br />
<span class="medgenPMjournal">Int J Biol Macromol</span>
2023 Feb 1;227:462-471.
Epub 2022 Dec 12
doi: 10.1016/j.ijbiomac.2022.12.079.
<span class="bold">PMID: </span><a href="/pubmed/36521712" target="_blank">36521712</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33495915">Spleen elastography in patients with Systemic sclerosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Karalilova R,
Doykova K,
Batalov Z,
Doykov D,
Batalov A</span><br />
<span class="medgenPMjournal">Rheumatol Int</span>
2021 Mar;41(3):633-641.
Epub 2021 Jan 25
doi: 10.1007/s00296-020-04772-5.
<span class="bold">PMID: </span><a href="/pubmed/33495915" target="_blank">33495915</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (40)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38564380">Efficacy and Tolerability of Topical 0.1% Stabilized Bioactive Retinol for Photoaging: A Vehicle-Controlled Integrated Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Farris P,
Berson D,
Bhatia N,
Goldberg D,
Lain E,
Mariwalla K,
Zeichner J,
Miller D,
McGuire T,
Kizoulis M</span><br />
<span class="medgenPMjournal">J Drugs Dermatol</span>
2024 Apr 1;23(4):209-215.
doi: 10.36849/JDD.8124.
<span class="bold">PMID: </span><a href="/pubmed/38564380" target="_blank">38564380</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37683065">Restoration of Aging Body Skin: Evidence-Based Development of a Topical Formulation for Improving Body Skin Quality.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Makino ET,
Jiang LI,
Acevedo SF,
Nguyen A,
Cheng T,
Kadoya K,
Mehta RC</span><br />
<span class="medgenPMjournal">J Drugs Dermatol</span>
2023 Sep 1;22(9):887-897.
doi: 10.36849/JDD.7292.
<span class="bold">PMID: </span><a href="/pubmed/37683065" target="_blank">37683065</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30406640">Rutosides for treatment of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morling JR,
Broderick C,
Yeoh SE,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Nov 8;11(11):CD005625.
doi: 10.1002/14651858.CD005625.pub4.
<span class="bold">PMID: </span><a href="/pubmed/30406640" target="_blank">30406640</a><a href="/pmc/articles/PMC6517027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28950030">Compression therapy for prevention of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Appelen D,
van Loo E,
Prins MH,
Neumann MH,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Sep 26;9(9):CD004174.
doi: 10.1002/14651858.CD004174.pub3.
<span class="bold">PMID: </span><a href="/pubmed/28950030" target="_blank">28950030</a><a href="/pmc/articles/PMC6483721" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11705091">Estrogen and skin. An overview.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah MG,
Maibach HI</span><br />
<span class="medgenPMjournal">Am J Clin Dermatol</span>
2001;2(3):143-50.
doi: 10.2165/00128071-200102030-00003.
<span class="bold">PMID: </span><a href="/pubmed/11705091" target="_blank">11705091</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (44)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/40035992">Ultrasound Beyond Joints: A Review of Extra-Articular Applications in Rheumatology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">D'Ignazio E,
Corradini D,
Cazenave T,
Bixio R,
Baldi C,
Ubhi HK,
Smith K,
Wakefield RJ,
Emery P,
Di Matteo A</span><br />
<span class="medgenPMjournal">Curr Rheumatol Rep</span>
2025 Mar 4;27(1):20.
doi: 10.1007/s11926-025-01186-9.
<span class="bold">PMID: </span><a href="/pubmed/40035992" target="_blank">40035992</a><a href="/pmc/articles/PMC11880079" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36149008">Subcutaneous Drug Delivery: A Review of the State-of-the-Art Modeling and Experimental Techniques.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma P,
Gajula K,
Dingari NN,
Gupta R,
Gopal S,
Rai B,
Iacocca RG</span><br />
<span class="medgenPMjournal">J Biomech Eng</span>
2023 Feb 1;145(2)
doi: 10.1115/1.4055758.
<span class="bold">PMID: </span><a href="/pubmed/36149008" target="_blank">36149008</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28961078">Far-Infrared Radiation Thermotherapy Improves Tissue Fibrosis in Chronic Extremity Lymphedema.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Li K,
Zhang Z,
Liu NF,
Sadigh P,
Evans VJ,
Zhou H,
Gao W,
Zhang YX</span><br />
<span class="medgenPMjournal">Lymphat Res Biol</span>
2018 Jun;16(3):248-257.
Epub 2017 Sep 29
doi: 10.1089/lrb.2016.0057.
<span class="bold">PMID: </span><a href="/pubmed/28961078" target="_blank">28961078</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21292298">Expression of vitamin D receptor decreases during progression of pigmented skin lesions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Brożyna AA,
Jozwicki W,
Janjetovic Z,
Slominski AT</span><br />
<span class="medgenPMjournal">Hum Pathol</span>
2011 May;42(5):618-31.
Epub 2011 Feb 2
doi: 10.1016/j.humpath.2010.09.014.
<span class="bold">PMID: </span><a href="/pubmed/21292298" target="_blank">21292298</a><a href="/pmc/articles/PMC3078192" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15036272">A mechanistic model for the aging of human skin.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Giacomoni PU,
Rein G</span><br />
<span class="medgenPMjournal">Micron</span>
2004;35(3):179-84.
doi: 10.1016/j.micron.2003.11.004.
<span class="bold">PMID: </span><a href="/pubmed/15036272" target="_blank">15036272</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36149008">Subcutaneous Drug Delivery: A Review of the State-of-the-Art Modeling and Experimental Techniques.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma P,
Gajula K,
Dingari NN,
Gupta R,
Gopal S,
Rai B,
Iacocca RG</span><br />
<span class="medgenPMjournal">J Biomech Eng</span>
2023 Feb 1;145(2)
doi: 10.1115/1.4055758.
<span class="bold">PMID: </span><a href="/pubmed/36149008" target="_blank">36149008</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33853085">Facial Skin Biophysical Profile of Women in Malaysia: Significance of Facial Skincare Product Use.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goh CF,
Mohamed Faisal N,
Ismail FN</span><br />
<span class="medgenPMjournal">Skin Pharmacol Physiol</span>
2021;34(6):351-362.
Epub 2021 Apr 14
doi: 10.1159/000514995.
<span class="bold">PMID: </span><a href="/pubmed/33853085" target="_blank">33853085</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33386899">High-resolution ultrasound imaging of skin involvement in systemic sclerosis: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dźwigała M,
Sobolewski P,
Maślińska M,
Yurtsever I,
Szymańska E,
Walecka I</span><br />
<span class="medgenPMjournal">Rheumatol Int</span>
2021 Feb;41(2):285-295.
Epub 2021 Jan 2
doi: 10.1007/s00296-020-04761-8.
<span class="bold">PMID: </span><a href="/pubmed/33386899" target="_blank">33386899</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30406640">Rutosides for treatment of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morling JR,
Broderick C,
Yeoh SE,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Nov 8;11(11):CD005625.
doi: 10.1002/14651858.CD005625.pub4.
<span class="bold">PMID: </span><a href="/pubmed/30406640" target="_blank">30406640</a><a href="/pmc/articles/PMC6517027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29392767">Does dietary fluid intake affect skin hydration in healthy humans? A systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akdeniz M,
Tomova-Simitchieva T,
Dobos G,
Blume-Peytavi U,
Kottner J</span><br />
<span class="medgenPMjournal">Skin Res Technol</span>
2018 Aug;24(3):459-465.
Epub 2018 Feb 2
doi: 10.1111/srt.12454.
<span class="bold">PMID: </span><a href="/pubmed/29392767" target="_blank">29392767</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (49)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/33386899">High-resolution ultrasound imaging of skin involvement in systemic sclerosis: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Dźwigała M,
Sobolewski P,
Maślińska M,
Yurtsever I,
Szymańska E,
Walecka I</span><br />
<span class="medgenPMjournal">Rheumatol Int</span>
2021 Feb;41(2):285-295.
Epub 2021 Jan 2
doi: 10.1007/s00296-020-04761-8.
<span class="bold">PMID: </span><a href="/pubmed/33386899" target="_blank">33386899</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30406640">Rutosides for treatment of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morling JR,
Broderick C,
Yeoh SE,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2018 Nov 8;11(11):CD005625.
doi: 10.1002/14651858.CD005625.pub4.
<span class="bold">PMID: </span><a href="/pubmed/30406640" target="_blank">30406640</a><a href="/pmc/articles/PMC6517027" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29392767">Does dietary fluid intake affect skin hydration in healthy humans? A systematic literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Akdeniz M,
Tomova-Simitchieva T,
Dobos G,
Blume-Peytavi U,
Kottner J</span><br />
<span class="medgenPMjournal">Skin Res Technol</span>
2018 Aug;24(3):459-465.
Epub 2018 Feb 2
doi: 10.1111/srt.12454.
<span class="bold">PMID: </span><a href="/pubmed/29392767" target="_blank">29392767</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28950030">Compression therapy for prevention of post-thrombotic syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Appelen D,
van Loo E,
Prins MH,
Neumann MH,
Kolbach DN</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2017 Sep 26;9(9):CD004174.
doi: 10.1002/14651858.CD004174.pub3.
<span class="bold">PMID: </span><a href="/pubmed/28950030" target="_blank">28950030</a><a href="/pmc/articles/PMC6483721" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27199229">Ethosomes and Transfersomes: Principles, Perspectives and Practices.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garg V,
Singh H,
Bimbrawh S,
Singh SK,
Gulati M,
Vaidya Y,
Kaur P</span><br />
<span class="medgenPMjournal">Curr Drug Deliv</span>
2017;14(5):613-633.
doi: 10.2174/1567201813666160520114436.
<span class="bold">PMID: </span><a href="/pubmed/27199229" target="_blank">27199229</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lack%20of%20skin%20elasticity%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div></div>
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