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<!--
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||
UID=870541
|
||
ConceptID=C4024989
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hereditary nonpolyposis colorectal carcinoma</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870541</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4024989</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006716">HP:0006716</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4024989[DISCUI]&test_type=Clinical" ref="ncbi_uid=870541">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=870541" ref="ncbi_uid=870541">V</a></span></span><span class="TLline">Hereditary nonpolyposis colorectal carcinoma</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/7130" ref="tree=MeSH" title="MedGen record for Intestinal disorder">Intestinal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/1049" ref="tree=MeSH" title="MedGen record for Colonic disorder">Colonic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/3171" ref="tree=MeSH" title="MedGen record for Neoplasm of the large intestine">Neoplasm of the large intestine</a></span><ul><li><span class="matched_ds">Hereditary nonpolyposis colorectal carcinoma</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_83428"><div><strong>Colorectal cancer</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83428</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0346629</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83428">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_318886"><div><strong>Lynch syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>318886</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833477</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome-5 (LYNCH5), or hereditary nonpolyposis colorectal cancer type 5 (HNPCC5), is a cancer predisposition syndrome characterized by onset of colorectal cancer and/or extracolonic cancers, particularly endometrial cancer, usually in mid-adulthood. The disorder shows autosomal dominant inheritance with incomplete penetrance (summary by Castellsague et al., 2015). For a general phenotypic description and a discussion of genetic heterogeneity of Lynch syndrome, see 120435.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/318886">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325005"><div><strong>Lynch syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325005</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838333</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome-4 (LYNCH4), or hereditary nonpolyposis colorectal cancer type 4 (HNPCC4), is an autosomal dominant disorder characterized primarily by the development of early-onset colorectal cancer. It is associated with the development of a variety of epithelial tumors that include endometrial cancer, stomach cancer, and ovarian cancer (summary by Thompson et al., 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325005">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_346893"><div><strong>Colorectal cancer, hereditary nonpolyposis, type 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346893</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858380</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any hereditary nonpolyposis colon cancer in which the cause of the disease is a mutation in the MLH3 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/346893">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_348732"><div><strong>Colorectal cancer, hereditary nonpolyposis, type 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>348732</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1860896</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any hereditary nonpolyposis colon cancer in which the cause of the disease is a mutation in the TGFBR2 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/348732">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_436445"><div><strong>Colorectal cancer, susceptibility to, 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>436445</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2675481</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any colorectal cancer in which the cause of the disease is a mutation in the POLD1 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/436445">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_412966"><div><strong>Lynch syndrome 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>412966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2750471</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/412966">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83428" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Colorectal cancer</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_348732" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Colorectal cancer, hereditary nonpolyposis, type 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346893" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Colorectal cancer, hereditary nonpolyposis, type 7</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_436445" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Colorectal cancer, susceptibility to, 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325005" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lynch syndrome 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_318886" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lynch syndrome 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_412966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lynch syndrome 8</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16984061">Genetic screening by DNA technology: a systematic review of health economic evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogowski W</span><br />
|
||
<span class="medgenPMjournal">Int J Technol Assess Health Care</span>
|
||
2006 Summer;22(3):327-37.
|
||
doi: 10.1017/s0266462306051221.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16984061" target="_blank">16984061</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16870997">Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hendriks YM,
|
||
de Jong AE,
|
||
Morreau H,
|
||
Tops CM,
|
||
Vasen HF,
|
||
Wijnen JT,
|
||
Breuning MH,
|
||
Bröcker-Vriends AH</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2006 Jul-Aug;56(4):213-25.
|
||
doi: 10.3322/canjclin.56.4.213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16870997" target="_blank">16870997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15745097">Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouraklis G,
|
||
Misiakos EP</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2005 Feb;50(2):336-44.
|
||
doi: 10.1007/s10620-005-1607-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15745097" target="_blank">15745097</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hereditary%20nonpolyposis%20colorectal%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (10)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16870997">Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): a guide for clinicians.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hendriks YM,
|
||
de Jong AE,
|
||
Morreau H,
|
||
Tops CM,
|
||
Vasen HF,
|
||
Wijnen JT,
|
||
Breuning MH,
|
||
Bröcker-Vriends AH</span><br />
|
||
<span class="medgenPMjournal">CA Cancer J Clin</span>
|
||
2006 Jul-Aug;56(4):213-25.
|
||
doi: 10.3322/canjclin.56.4.213.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16870997" target="_blank">16870997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15745097">Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouraklis G,
|
||
Misiakos EP</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2005 Feb;50(2):336-44.
|
||
doi: 10.1007/s10620-005-1607-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15745097" target="_blank">15745097</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10224689">Hereditary colorectal carcinoma syndromes and their implications for colorectal carcinoma in Puerto Rico.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mosquera RA,
|
||
Lynch HT</span><br />
|
||
<span class="medgenPMjournal">Bol Asoc Med P R</span>
|
||
1998 Jul-Dec;90(7-12):140-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10224689" target="_blank">10224689</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7879846">The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Emilia JC,
|
||
Rodriguez-Bigas MA,
|
||
Petrelli NJ</span><br />
|
||
<span class="medgenPMjournal">Am J Surg</span>
|
||
1995 Mar;169(3):368-72.
|
||
doi: 10.1016/S0002-9610(99)80178-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7879846" target="_blank">7879846</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8074841">Hereditary nonpolyposis colorectal carcinoma (HNPCC): clinical application of molecular diagnostic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch PM</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
1994 Jun;26(3):221-8.
|
||
doi: 10.3109/07853899409147894.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8074841" target="_blank">8074841</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (43)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26930387">Hereditary non-BRCA gynecological tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vellone VG,
|
||
Paudice M,
|
||
Varesco L</span><br />
|
||
<span class="medgenPMjournal">Minerva Ginecol</span>
|
||
2016 Oct;68(5):579-86.
|
||
Epub 2016 Mar 1
|
||
<span class="bold">PMID: </span><a href="/pubmed/26930387" target="_blank">26930387</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15745097">Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouraklis G,
|
||
Misiakos EP</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2005 Feb;50(2):336-44.
|
||
doi: 10.1007/s10620-005-1607-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15745097" target="_blank">15745097</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10224689">Hereditary colorectal carcinoma syndromes and their implications for colorectal carcinoma in Puerto Rico.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mosquera RA,
|
||
Lynch HT</span><br />
|
||
<span class="medgenPMjournal">Bol Asoc Med P R</span>
|
||
1998 Jul-Dec;90(7-12):140-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10224689" target="_blank">10224689</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7879846">The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Emilia JC,
|
||
Rodriguez-Bigas MA,
|
||
Petrelli NJ</span><br />
|
||
<span class="medgenPMjournal">Am J Surg</span>
|
||
1995 Mar;169(3):368-72.
|
||
doi: 10.1016/S0002-9610(99)80178-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7879846" target="_blank">7879846</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8074840">Genetic basis of hereditary nonpolyposis colorectal carcinoma (HNPCC).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Peltomäki PT</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
1994 Jun;26(3):215-9.
|
||
doi: 10.3109/07853899409147893.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8074840" target="_blank">8074840</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (53)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/12436451">Antibody-based screening for hereditary nonpolyposis colorectal carcinoma compared with microsatellite analysis and sequencing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Christensen M,
|
||
Katballe N,
|
||
Wikman F,
|
||
Primdahl H,
|
||
Sørensen FB,
|
||
Laurberg S,
|
||
Ørntoft TF</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2002 Dec 1;95(11):2422-30.
|
||
doi: 10.1002/cncr.10979.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12436451" target="_blank">12436451</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9849580">Microsatellite instability and frameshift mutations in the Bax gene in hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sakao Y,
|
||
Noro M,
|
||
Sekine S,
|
||
Nozue M,
|
||
Hirohashi S,
|
||
Itoh T,
|
||
Noguchi M</span><br />
|
||
<span class="medgenPMjournal">Jpn J Cancer Res</span>
|
||
1998 Oct;89(10):1020-7.
|
||
doi: 10.1111/j.1349-7006.1998.tb00491.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9849580" target="_blank">9849580</a><a href="/pmc/articles/PMC5921699" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7937908">Microsatellite alterations as clonal markers for the detection of human cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mao L,
|
||
Lee DJ,
|
||
Tockman MS,
|
||
Erozan YS,
|
||
Askin F,
|
||
Sidransky D</span><br />
|
||
<span class="medgenPMjournal">Proc Natl Acad Sci U S A</span>
|
||
1994 Oct 11;91(21):9871-5.
|
||
doi: 10.1073/pnas.91.21.9871.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7937908" target="_blank">7937908</a><a href="/pmc/articles/PMC44919" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/15745097">Hereditary nonpolyposis colorectal cancer (Lynch syndrome): criteria for identification and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouraklis G,
|
||
Misiakos EP</span><br />
|
||
<span class="medgenPMjournal">Dig Dis Sci</span>
|
||
2005 Feb;50(2):336-44.
|
||
doi: 10.1007/s10620-005-1607-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15745097" target="_blank">15745097</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15236168">Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hendriks YM,
|
||
Wagner A,
|
||
Morreau H,
|
||
Menko F,
|
||
Stormorken A,
|
||
Quehenberger F,
|
||
Sandkuijl L,
|
||
Møller P,
|
||
Genuardi M,
|
||
Van Houwelingen H,
|
||
Tops C,
|
||
Van Puijenbroek M,
|
||
Verkuijlen P,
|
||
Kenter G,
|
||
Van Mil A,
|
||
Meijers-Heijboer H,
|
||
Tan GB,
|
||
Breuning MH,
|
||
Fodde R,
|
||
Wijnen JT,
|
||
Bröcker-Vriends AH,
|
||
Vasen H</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2004 Jul;127(1):17-25.
|
||
doi: 10.1053/j.gastro.2004.03.068.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15236168" target="_blank">15236168</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14584079">Familial sarcoma: challenging pedigrees.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch HT,
|
||
Deters CA,
|
||
Hogg D,
|
||
Lynch JF,
|
||
Kinarsky Y,
|
||
Gatalica Z</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2003 Nov 1;98(9):1947-57.
|
||
doi: 10.1002/cncr.11743.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14584079" target="_blank">14584079</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7879846">The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Emilia JC,
|
||
Rodriguez-Bigas MA,
|
||
Petrelli NJ</span><br />
|
||
<span class="medgenPMjournal">Am J Surg</span>
|
||
1995 Mar;169(3):368-72.
|
||
doi: 10.1016/S0002-9610(99)80178-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7879846" target="_blank">7879846</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1310886">The association between cholangiocarcinoma and hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mecklin JP,
|
||
Järvinen HJ,
|
||
Virolainen M</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1992 Mar 1;69(5):1112-4.
|
||
doi: 10.1002/cncr.2820690508.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1310886" target="_blank">1310886</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (23)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/15236168">Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hendriks YM,
|
||
Wagner A,
|
||
Morreau H,
|
||
Menko F,
|
||
Stormorken A,
|
||
Quehenberger F,
|
||
Sandkuijl L,
|
||
Møller P,
|
||
Genuardi M,
|
||
Van Houwelingen H,
|
||
Tops C,
|
||
Van Puijenbroek M,
|
||
Verkuijlen P,
|
||
Kenter G,
|
||
Van Mil A,
|
||
Meijers-Heijboer H,
|
||
Tan GB,
|
||
Breuning MH,
|
||
Fodde R,
|
||
Wijnen JT,
|
||
Bröcker-Vriends AH,
|
||
Vasen H</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2004 Jul;127(1):17-25.
|
||
doi: 10.1053/j.gastro.2004.03.068.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15236168" target="_blank">15236168</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14692024">Hereditary nonpolyposis colorectal carcinoma (HNPCC) and HNPCC-like families: Problems in diagnosis, surveillance, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lynch HT,
|
||
Riley BD,
|
||
Weissman SM,
|
||
Coronel SM,
|
||
Kinarsky Y,
|
||
Lynch JF,
|
||
Shaw TG,
|
||
Rubinstein WS</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2004 Jan 1;100(1):53-64.
|
||
doi: 10.1002/cncr.11912.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14692024" target="_blank">14692024</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11920458">Evaluation of screening strategy for detecting hereditary nonpolyposis colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Furukawa T,
|
||
Konishi F,
|
||
Shitoh K,
|
||
Kojima M,
|
||
Nagai H,
|
||
Tsukamoto T</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
2002 Feb 15;94(4):911-20.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11920458" target="_blank">11920458</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8074839">Prevalence of hereditary nonpolyposis colorectal carcinoma (HNPCC).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ponz de Leon M</span><br />
|
||
<span class="medgenPMjournal">Ann Med</span>
|
||
1994 Jun;26(3):209-14.
|
||
doi: 10.3109/07853899409147892.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8074839" target="_blank">8074839</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2820826">Frequency of hereditary colorectal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mecklin JP</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
1987 Nov;93(5):1021-5.
|
||
doi: 10.1016/0016-5085(87)90565-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2820826" target="_blank">2820826</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (38)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/18197053">A systematic review of perceived risks, psychological and behavioral impacts of genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Heshka JT,
|
||
Palleschi C,
|
||
Howley H,
|
||
Wilson B,
|
||
Wells PS</span><br />
|
||
<span class="medgenPMjournal">Genet Med</span>
|
||
2008 Jan;10(1):19-32.
|
||
doi: 10.1097/GIM.0b013e31815f524f.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18197053" target="_blank">18197053</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16984061">Genetic screening by DNA technology: a systematic review of health economic evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rogowski W</span><br />
|
||
<span class="medgenPMjournal">Int J Technol Assess Health Care</span>
|
||
2006 Summer;22(3):327-37.
|
||
doi: 10.1017/s0266462306051221.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16984061" target="_blank">16984061</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4024989%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (15)</a></li>
|
||
<li><a href="/gtr/tests?term=C4024989%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (15)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C4024989%5bDISCUI%5d" target="_blank">See all (15)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Hereditary%20nonpolyposis%20colorectal%20carcinoma" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hereditary%20nonpolyposis%20colorectal%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Hereditary%20nonpolyposis%20colorectal%20carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet mgSection" id="ID_116">
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Hereditary%20nonpolyposis%20colorectal%20carcinoma" target="_blank">MedlinePlus</a></li></ul></div>
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|
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|
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<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
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<h3>Reviews</h3>
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<ul>
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<li>
|
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<a href="/pubmed/clinical?term=Hereditary%20nonpolyposis%20colorectal%20carcinoma" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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|
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<li>
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<a href="/pubmed?term=Hereditary%20nonpolyposis%20colorectal%20carcinoma%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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|
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<!-- MedGen supplemental column ends here -->
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|
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<h3>Related information</h3>
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||
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<div class="portlet_content DiscoveryDbLinks">
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<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=870541" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4024989[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C4024989[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=870541" ref="log$=recordlinks">PMC Articles</a>
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<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=870541" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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||
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||
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||
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|
||
|
||
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||
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||
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<h3>Recent activity</h3>
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|
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<div class="action">
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
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Clear
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|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
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Turn Off
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|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.HistoryToggle">
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Turn On
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|
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|
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<ul id="activity">
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67d68ed284f3725e59b40003">Hereditary nonpolyposis colorectal carcinoma</a>
|
||
<div class="ralinkpop offscreen_noflow">Hereditary nonpolyposis colorectal carcinoma<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67d68ed02f30673f7b81aa68">Endometrial carcinoma</a>
|
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<div class="ralinkpop offscreen_noflow">Endometrial carcinoma<div class="brieflinkpopdesc"></div></div>
|
||
<div class="tertiary">MedGen</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67d68ea884f3725e59b33cf5">MLH1 mutL homolog 1 [Homo sapiens]</a>
|
||
<div class="ralinkpop offscreen_noflow">MLH1 mutL homolog 1 [Homo sapiens]<div class="brieflinkpopdesc">Gene ID:4292</div></div>
|
||
<div class="tertiary">Gene</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67d68ea72f30673f7b810b6c">Colorectal cancer, hereditary nonpolyposis, type 2</a>
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