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<!--
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UID=870477
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ConceptID=C4024923
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Diffuse white matter abnormalities</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>870477</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4024923</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
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<td>White matter abnormalities, diffuse</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0007204">HP:0007204</a></td></tr>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Diffuse white matter abnormalities</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/892343" ref="tree=MeSH" title="MedGen record for Morphological central nervous system abnormality">Morphological central nervous system abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/866738" ref="tree=MeSH" title="MedGen record for Abnormal brain morphology">Abnormal brain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/866620" ref="tree=MeSH" title="MedGen record for Abnormal forebrain morphology">Abnormal forebrain morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867394" ref="tree=MeSH" title="MedGen record for Abnormal cerebral morphology">Abnormal cerebral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/866852" ref="tree=MeSH" title="MedGen record for Abnormal cerebral subcortex morphology">Abnormal cerebral subcortex morphology</a></span><ul><li><span class="TLline"><a href="/medgen/181756" ref="tree=MeSH" title="MedGen record for Abnormal cerebral white matter morphology">Abnormal cerebral white matter morphology</a></span><ul><li><span class="matched_ds">Diffuse white matter abnormalities</span><ul><li><span class="TLline"><a href="/medgen/1647411" ref="tree=MeSH" title="MedGen record for Confluent hypointensity of cerebral white matter on MRI">Confluent hypointensity of cerebral white matter on MRI</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_162893"><div><strong>Agenesis of the corpus callosum with peripheral neuropathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>162893</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0795950</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), a neurodevelopmental and neurodegenerative disorder, is characterized by severe progressive sensorimotor neuropathy with resulting hypotonia, areflexia, and amyotrophy, and by variable degrees of dysgenesis of the corpus callosum. Mild-to-severe intellectual disability and "psychotic episodes" during adolescence are observed. Sensory modalities are moderately to severely affected beginning in infancy. The average age of onset of walking is 3.8 years; the average age of loss of walking is 13.8 years; the average age of death is 33 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/162893">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325051"><div><strong>CARASIL syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325051</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838577</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">HTRA1 disorder is a phenotypic spectrum in which some individuals have few to no symptoms and others manifest with the more severe CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) phenotype. Those who have a heterozygous HTRA1 pathogenic variant may have mild neurologic findings (sometimes identified only on neuroimaging) or mild-to-moderate neurologic signs and symptoms of CARASIL. In this chapter, the term "classic CARASIL" refers to the more severe phenotype associated with biallelic pathogenic variants, and "HTRA1 cerebral small vessel disease" (HTRA1-CSVD) refers to the milder phenotype associated with a heterozygous HTRA1 pathogenic variant. Classic CARASIL is characterized by early-onset changes in the deep white matter of the brain observed on MRI, and associated neurologic findings. The most frequent initial symptom is gait disturbance from spasticity beginning between ages 20 and 40 years. Forty-four percent of affected individuals have stroke-like episodes before age 40 years. Mood changes (apathy and irritability), pseudobulbar palsy, and cognitive dysfunction begin between ages 20 and 50 years. The disease progresses slowly following the onset of neurologic symptoms. Scalp alopecia and acute mid- to lower-back pain (lumbago) before age 30 years are characteristic. The most frequent initial symptom in individuals with HTRA1-CSVD is slowly progressive gait disturbance after age 40 years, which may be followed by the development of mood changes and cognitive dysfunction. A majority of affected individuals have a stroke-like episode after age 40 years. Spondylosis and alopecia are seen in a minority of individuals with HTRA1-CSVD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325051">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_409627"><div><strong>Autosomal recessive osteopetrosis 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>409627</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1968603</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal recessive osteopetrosis-5 (OPTB5) is a form of infantile malignant osteopetrosis, characterized by defective osteoclast function resulting in decreased bone resorption and generalized osteosclerosis. Defective resorption causes development of densely sclerotic fragile bones and progressive obliteration of the marrow spaces and cranial foramina. Marrow obliteration is associated with extramedullary hematopoiesis and hepatosplenomegaly, and results in anemia and thrombocytopenia, whereas nerve entrapment accounts for progressive blindness and hearing loss. Other major manifestations include failure to thrive, pathologic fractures, and increased infection rate. Most affected children succumb to severe bone marrow failure and overwhelming infection in the first few years of life (summary by Quarello et al., 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/409627">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_416526"><div><strong>RIN2 syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416526</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2751321</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">MACS syndrome is an autosomal recessive connective tissue disorder named for the variable features of macrocephaly, alopecia, cutis laxa, and scoliosis (summary by Kameli et al., 2020).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/416526">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462705"><div><strong>Megalencephalic leukoencephalopathy with subcortical cysts 2A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462705</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151355</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterized by two phenotypes: classic MLC and improving MLC. Individuals with classic MLC present with macrocephaly, often in association with seizures, gradual onset of ataxia, spasticity, and sometimes extrapyramidal findings, mild gross motor developmental delays, and late-onset cognitive deterioration. Macrocephaly, observed in most affected individuals, may be present at birth but more frequently develops during the first year of life. The degree of macrocephaly is variable, with head circumferences reaching four to six standard deviations greater than the mean. After the first year of life, head growth trajectory typically normalizes and growth follows a line parallel to, although several standard deviations above, the 98th centile. Initial mental and motor development is normal in most individuals. Walking is often unstable, followed by ataxia of the trunk and extremities, pyramidal dysfunction, and brisk deep tendon reflexes. Early-onset seizures are common, and approximately 60% of individuals have epilepsy that is typically well controlled with anti-seizure medication, but status epilepticus occurs relatively frequently. Cognitive deterioration occurs later in the course of the disease and is usually mild in severity. Overall disease severity varies, with some individuals being able to ambulate independently for only a few years from disease onset to other individuals continuing to independently walk in the fifth decade of life. Individuals with improving MLC have a similar initial presentation with delayed cognitive or motor development, followed by an improving clinical course: macrocephaly usually persists, but some children become normocephalic; motor function improves or normalizes; hypotonia and clumsiness may persist in some or neurologic examination may become normal. Some individuals have intellectual disability that is stable, with or without autism spectrum disorder. Epilepsy is much less frequent than in classic MLC.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462705">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462706"><div><strong>Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without intellectual disability</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462706</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151356</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is characterized by two phenotypes: classic MLC and improving MLC. Individuals with classic MLC present with macrocephaly, often in association with seizures, gradual onset of ataxia, spasticity, and sometimes extrapyramidal findings, mild gross motor developmental delays, and late-onset cognitive deterioration. Macrocephaly, observed in most affected individuals, may be present at birth but more frequently develops during the first year of life. The degree of macrocephaly is variable, with head circumferences reaching four to six standard deviations greater than the mean. After the first year of life, head growth trajectory typically normalizes and growth follows a line parallel to, although several standard deviations above, the 98th centile. Initial mental and motor development is normal in most individuals. Walking is often unstable, followed by ataxia of the trunk and extremities, pyramidal dysfunction, and brisk deep tendon reflexes. Early-onset seizures are common, and approximately 60% of individuals have epilepsy that is typically well controlled with anti-seizure medication, but status epilepticus occurs relatively frequently. Cognitive deterioration occurs later in the course of the disease and is usually mild in severity. Overall disease severity varies, with some individuals being able to ambulate independently for only a few years from disease onset to other individuals continuing to independently walk in the fifth decade of life. Individuals with improving MLC have a similar initial presentation with delayed cognitive or motor development, followed by an improving clinical course: macrocephaly usually persists, but some children become normocephalic; motor function improves or normalizes; hypotonia and clumsiness may persist in some or neurologic examination may become normal. Some individuals have intellectual disability that is stable, with or without autism spectrum disorder. Epilepsy is much less frequent than in classic MLC.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462706">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_908888"><div><strong>Leukodystrophy and acquired microcephaly with or without dystonia;</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>908888</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225213</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/908888">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748867"><div><strong>Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748867</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399977</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mitochondrial complex IV deficiency nuclear type 2 (MC4DN2) is an autosomal recessive multisystem metabolic disorder characterized by the onset of symptoms at birth or in the first weeks or months of life. Affected individuals have severe hypotonia, often associated with feeding difficulties and respiratory insufficiency necessitating tube feeding and mechanical ventilation. The vast majority of patients develop hypertrophic cardiomyopathy in the first days or weeks of life, which usually leads to death in infancy or early childhood. Patients also show neurologic abnormalities, including developmental delay, nystagmus, fasciculations, dystonia, EEG changes, and brain imaging abnormalities compatible with a diagnosis of Leigh syndrome (see 256000). There may also be evidence of systemic involvement with hepatomegaly and myopathy, although neurogenic muscle atrophy is more common and may resemble spinal muscular atrophy type I (SMA1; 253300). Serum lactate is increased, and laboratory studies show decreased mitochondrial complex IV protein and activity levels in various tissues, including heart and skeletal muscle. Most patients die in infancy of cardiorespiratory failure (summary by Papadopoulou et al., 1999). For a discussion of genetic heterogeneity of mitochondrial complex IV (cytochrome c oxidase) deficiency, see 220110.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748867">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_162893" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Agenesis of the corpus callosum with peripheral neuropathy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_409627" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive osteopetrosis 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325051" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CARASIL syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748867" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_908888" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukodystrophy and acquired microcephaly with or without dystonia;</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462705" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Megalencephalic leukoencephalopathy with subcortical cysts 2A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462706" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Megalencephalic leukoencephalopathy with subcortical cysts 2B, remitting, with or without intellectual disability</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416526" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">RIN2 syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32467104">Posterior reversible encephalopathy syndrome (PRES): presentation, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Parasher A,
|
||
Jhamb R</span><br />
|
||
<span class="medgenPMjournal">Postgrad Med J</span>
|
||
2020 Oct;96(1140):623-628.
|
||
Epub 2020 May 28
|
||
doi: 10.1136/postgradmedj-2020-137706.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32467104" target="_blank">32467104</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31297957">A DTI study of leukoaraiosis and the differential diagnosis between leukoaraiosis and acute lacunar infarction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao DQ,
|
||
Wang ZW,
|
||
Cheng Y,
|
||
Yuan Z,
|
||
Rene F,
|
||
Liu H,
|
||
Pliss A,
|
||
Luan P</span><br />
|
||
<span class="medgenPMjournal">CNS Neurosci Ther</span>
|
||
2019 Sep;25(9):1064-1067.
|
||
Epub 2019 Jul 11
|
||
doi: 10.1111/cns.13191.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31297957" target="_blank">31297957</a><a href="/pmc/articles/PMC6698974" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21257930">Differential diagnosis for bilateral abnormalities of the basal ganglia and thalamus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hegde AN,
|
||
Mohan S,
|
||
Lath N,
|
||
Lim CC</span><br />
|
||
<span class="medgenPMjournal">Radiographics</span>
|
||
2011 Jan-Feb;31(1):5-30.
|
||
doi: 10.1148/rg.311105041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21257930" target="_blank">21257930</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(diffuse%20white%20matter%20abnormalities)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (54)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38865876">Multimodal imaging analyses in neuromyelitis optica spectrum disorder with or without visual disturbance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakaya M,
|
||
Sato N,
|
||
Suzuki F,
|
||
Maikusa N,
|
||
Matsuda H,
|
||
Kimura Y,
|
||
Shigemoto Y,
|
||
Chiba E,
|
||
Ota M,
|
||
Yamamura T,
|
||
Sato W,
|
||
Okamoto T,
|
||
Abe O</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
2024 Jul 15;462:123090.
|
||
Epub 2024 Jun 6
|
||
doi: 10.1016/j.jns.2024.123090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38865876" target="_blank">38865876</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32272373">Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Filip P,
|
||
Svatkova A,
|
||
Carpenter AF,
|
||
Eberly LE,
|
||
Nestrasil I,
|
||
Nissi MJ,
|
||
Michaeli S,
|
||
Mangia S</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2020;26:102234.
|
||
Epub 2020 Mar 2
|
||
doi: 10.1016/j.nicl.2020.102234.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32272373" target="_blank">32272373</a><a href="/pmc/articles/PMC7139162" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26216502">Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">He L,
|
||
Parikh NA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
2015 Oct;53(4):330-7.
|
||
Epub 2015 Jun 15
|
||
doi: 10.1016/j.pediatrneurol.2015.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26216502" target="_blank">26216502</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23791345">Deep coma and diffuse white matter abnormalities caused by sepsis-associated encephalopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luitse MJ,
|
||
van Asch CJ,
|
||
Klijn CJ</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2013 Jun 22;381(9884):2222.
|
||
doi: 10.1016/S0140-6736(13)60682-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23791345" target="_blank">23791345</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18230707">Leukoaraiosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Sullivan M</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2008 Feb;8(1):26-38.
|
||
doi: 10.1136/jnnp.2007.139428.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18230707" target="_blank">18230707</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20white%20matter%20abnormalities%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32272373">Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Filip P,
|
||
Svatkova A,
|
||
Carpenter AF,
|
||
Eberly LE,
|
||
Nestrasil I,
|
||
Nissi MJ,
|
||
Michaeli S,
|
||
Mangia S</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2020;26:102234.
|
||
Epub 2020 Mar 2
|
||
doi: 10.1016/j.nicl.2020.102234.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32272373" target="_blank">32272373</a><a href="/pmc/articles/PMC7139162" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28861337">Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hinojosa-Rodríguez M,
|
||
Harmony T,
|
||
Carrillo-Prado C,
|
||
Van Horn JD,
|
||
Irimia A,
|
||
Torgerson C,
|
||
Jacokes Z</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2017;16:355-368.
|
||
Epub 2017 Aug 14
|
||
doi: 10.1016/j.nicl.2017.08.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28861337" target="_blank">28861337</a><a href="/pmc/articles/PMC5568883" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24768314">Tractography reveals diffuse white matter abnormalities in Myotonic Dystrophy Type 1.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wozniak JR,
|
||
Mueller BA,
|
||
Lim KO,
|
||
Hemmy LS,
|
||
Day JW</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
2014 Jun 15;341(1-2):73-8.
|
||
Epub 2014 Apr 13
|
||
doi: 10.1016/j.jns.2014.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24768314" target="_blank">24768314</a><a href="/pmc/articles/PMC4042407" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23791345">Deep coma and diffuse white matter abnormalities caused by sepsis-associated encephalopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luitse MJ,
|
||
van Asch CJ,
|
||
Klijn CJ</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2013 Jun 22;381(9884):2222.
|
||
doi: 10.1016/S0140-6736(13)60682-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23791345" target="_blank">23791345</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18230707">Leukoaraiosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Sullivan M</span><br />
|
||
<span class="medgenPMjournal">Pract Neurol</span>
|
||
2008 Feb;8(1):26-38.
|
||
doi: 10.1136/jnnp.2007.139428.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18230707" target="_blank">18230707</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20white%20matter%20abnormalities%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16006499">Prognostic factors in patients presenting with severe neurological forms of Wilson's disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Prashanth LK,
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Taly AB,
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Sinha S,
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<span class="bold">PMID: </span><a href="/pubmed/12447113" target="_blank">12447113</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/2406415">Incidental white matter hyperintensities on magnetic resonance imaging in HIV-1 infection. Multicenter AIDS Cohort Study.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">McArthur JC,
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Kumar AJ,
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Johnson DW,
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<div class="nl"><a target="_blank" href="/pubmed/7108268">Leukoencephalopathy in patients treated with amphotericin B methyl ester.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ellis WG,
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<span class="bold">PMID: </span><a href="/pubmed/7108268" target="_blank">7108268</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20white%20matter%20abnormalities%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38865876">Multimodal imaging analyses in neuromyelitis optica spectrum disorder with or without visual disturbance.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Nakaya M,
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Sato N,
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Suzuki F,
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Maikusa N,
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Matsuda H,
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Kimura Y,
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Shigemoto Y,
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Chiba E,
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Ota M,
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Yamamura T,
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Sato W,
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Okamoto T,
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Abe O</span><br />
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Epub 2024 Jun 6
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doi: 10.1016/j.jns.2024.123090.
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<span class="bold">PMID: </span><a href="/pubmed/38865876" target="_blank">38865876</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/37898796">Current clinical presentations of AIDS dementia in a tropical environment: study of 26 observations in the neurology department of the University Hospital of Conakry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Touré ML,
|
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Sakadi F,
|
||
Keita MM,
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||
Carlos Othon G,
|
||
Diallo SM,
|
||
Baldé TH,
|
||
Kassa FD,
|
||
Diallo B,
|
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Hinima M,
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Diallo MB,
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Aminou SY,
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Camara N,
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Kadji JM,
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Konaté M,
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Cissé FA,
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Cissé A</span><br />
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<span class="medgenPMjournal">Eur J Med Res</span>
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2023 Oct 28;28(1):468.
|
||
doi: 10.1186/s40001-023-01423-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37898796" target="_blank">37898796</a><a href="/pmc/articles/PMC10612157" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28861337">Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hinojosa-Rodríguez M,
|
||
Harmony T,
|
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Carrillo-Prado C,
|
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Van Horn JD,
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Irimia A,
|
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Torgerson C,
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Jacokes Z</span><br />
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<span class="medgenPMjournal">Neuroimage Clin</span>
|
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2017;16:355-368.
|
||
Epub 2017 Aug 14
|
||
doi: 10.1016/j.nicl.2017.08.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28861337" target="_blank">28861337</a><a href="/pmc/articles/PMC5568883" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28540180">Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choi S,
|
||
Bush AM,
|
||
Borzage MT,
|
||
Joshi AA,
|
||
Mack WJ,
|
||
Coates TD,
|
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Leahy RM,
|
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Wood JC</span><br />
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<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2017;15:239-246.
|
||
Epub 2017 Apr 29
|
||
doi: 10.1016/j.nicl.2017.04.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28540180" target="_blank">28540180</a><a href="/pmc/articles/PMC5430155" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23791345">Deep coma and diffuse white matter abnormalities caused by sepsis-associated encephalopathy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luitse MJ,
|
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van Asch CJ,
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Klijn CJ</span><br />
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<span class="medgenPMjournal">Lancet</span>
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2013 Jun 22;381(9884):2222.
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||
doi: 10.1016/S0140-6736(13)60682-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23791345" target="_blank">23791345</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20white%20matter%20abnormalities%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38865876">Multimodal imaging analyses in neuromyelitis optica spectrum disorder with or without visual disturbance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nakaya M,
|
||
Sato N,
|
||
Suzuki F,
|
||
Maikusa N,
|
||
Matsuda H,
|
||
Kimura Y,
|
||
Shigemoto Y,
|
||
Chiba E,
|
||
Ota M,
|
||
Yamamura T,
|
||
Sato W,
|
||
Okamoto T,
|
||
Abe O</span><br />
|
||
<span class="medgenPMjournal">J Neurol Sci</span>
|
||
2024 Jul 15;462:123090.
|
||
Epub 2024 Jun 6
|
||
doi: 10.1016/j.jns.2024.123090.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38865876" target="_blank">38865876</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37898796">Current clinical presentations of AIDS dementia in a tropical environment: study of 26 observations in the neurology department of the University Hospital of Conakry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Touré ML,
|
||
Sakadi F,
|
||
Keita MM,
|
||
Carlos Othon G,
|
||
Diallo SM,
|
||
Baldé TH,
|
||
Kassa FD,
|
||
Diallo B,
|
||
Hinima M,
|
||
Diallo MB,
|
||
Aminou SY,
|
||
Camara N,
|
||
Kadji JM,
|
||
Konaté M,
|
||
Cissé FA,
|
||
Cissé A</span><br />
|
||
<span class="medgenPMjournal">Eur J Med Res</span>
|
||
2023 Oct 28;28(1):468.
|
||
doi: 10.1186/s40001-023-01423-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37898796" target="_blank">37898796</a><a href="/pmc/articles/PMC10612157" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28861337">Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hinojosa-Rodríguez M,
|
||
Harmony T,
|
||
Carrillo-Prado C,
|
||
Van Horn JD,
|
||
Irimia A,
|
||
Torgerson C,
|
||
Jacokes Z</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2017;16:355-368.
|
||
Epub 2017 Aug 14
|
||
doi: 10.1016/j.nicl.2017.08.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28861337" target="_blank">28861337</a><a href="/pmc/articles/PMC5568883" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28540180">Hemoglobin and mean platelet volume predicts diffuse T1-MRI white matter volume decrease in sickle cell disease patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Choi S,
|
||
Bush AM,
|
||
Borzage MT,
|
||
Joshi AA,
|
||
Mack WJ,
|
||
Coates TD,
|
||
Leahy RM,
|
||
Wood JC</span><br />
|
||
<span class="medgenPMjournal">Neuroimage Clin</span>
|
||
2017;15:239-246.
|
||
Epub 2017 Apr 29
|
||
doi: 10.1016/j.nicl.2017.04.023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28540180" target="_blank">28540180</a><a href="/pmc/articles/PMC5430155" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26216502">Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">He L,
|
||
Parikh NA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Neurol</span>
|
||
2015 Oct;53(4):330-7.
|
||
Epub 2015 Jun 15
|
||
doi: 10.1016/j.pediatrneurol.2015.05.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26216502" target="_blank">26216502</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Diffuse%20white%20matter%20abnormalities%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
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|
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|
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|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Diffuse%20white%20matter%20abnormalities" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(diffuse%20white%20matter%20abnormalities)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Diffuse%20white%20matter%20abnormalities" target="_blank">MedlinePlus</a></li></ul></div>
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<a href="/pubmed?term=Diffuse%20white%20matter%20abnormalities%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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