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<!--
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UID=869773
|
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ConceptID=C4024202
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Tooth agenesis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>869773</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4024202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Decreased number of teeth; Decreased tooth count; Failure of development of some teeth; Fewer teeth than normal; Missing some teeth; Reduced number of teeth</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0009804">HP:0009804</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">The absence of one or more teeth from the normal series by a failure to develop [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4024202[DISCUI]&test_type=Clinical" ref="ncbi_uid=869773">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=869773" ref="ncbi_uid=869773">V</a></span></span><span class="TLline">Tooth agenesis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/6447" ref="tree=MeSH" title="MedGen record for Abnormality of the mouth">Abnormality of the mouth</a></span><ul><li><span class="TLline"><a href="/medgen/1645271" ref="tree=MeSH" title="MedGen record for Abnormal oral morphology">Abnormal oral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871391" ref="tree=MeSH" title="MedGen record for Abnormal oral cavity morphology">Abnormal oral cavity morphology</a></span><ul><li><span class="TLline"><a href="/medgen/78084" ref="tree=MeSH" title="MedGen record for Abnormality of the dentition">Abnormality of the dentition</a></span><ul><li><span class="TLline"><a href="/medgen/220939" ref="tree=MeSH" title="MedGen record for Abnormal number of teeth">Abnormal number of teeth</a></span><ul><li><span class="matched_ds">Tooth agenesis</span><ul><li><span class="TLline"><a href="/medgen/98313" ref="tree=MeSH" title="MedGen record for Anodontia">Anodontia</a></span><ul><li><span class="TLline"><a href="/medgen/43794" ref="tree=MeSH" title="MedGen record for Hypodontia">Hypodontia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/904670" ref="tree=MeSH" title="MedGen record for Oligodontia">Oligodontia</a></span><ul><li><span class="TLline"><a href="/medgen/868598" ref="tree=MeSH" title="MedGen record for Oligodontia of primary teeth">Oligodontia of primary teeth</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/370882" ref="tree=MeSH" title="MedGen record for Selective tooth agenesis">Selective tooth agenesis</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_289648"><div><strong>Hypogonadotropic hypogonadism 2 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>289648</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1563720</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/289648">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_372057"><div><strong>Tooth agenesis, selective, 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>372057</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any tooth agenesis in which the cause of the disease is a mutation in the WNT10A gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/372057">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333092"><div><strong>Epiphyseal dysplasia, multiple, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333092</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838429</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children report fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333092">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_340124"><div><strong>Arrhythmogenic cardiomyopathy with wooly hair and keratoderma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>340124</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854063</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dilated cardiomyopathy with woolly hair and keratoderma (DCWHK) is characterized by the presence of woolly or sparse hair from birth. Some patients exhibit fragile skin with blisters/erosions after minor mechanical trauma, with hyperkeratosis and epidermolytic keratoderma developing in early childhood. Cardiomyopathy may become apparent in the first decade of life, and early death due to heart failure has been reported, but patients may remain asymptomatic into the fourth decade of life. Some patients exhibit an arrhythmogenic form of cardiomyopathy, with sudden death in early adulthood (Carvajal-Huerta, 1998; Whittock et al., 2002; Alcalai et al., 2003; Uzumcu et al., 2006). Another syndrome involving cardiomyopathy, woolly hair, and keratoderma (Naxos disease; 601214) is caused by mutation in the plakoglobin gene (JUP; 173325). Also see 610476 for a similar disorder caused by homozygous mutation in the DSC2 gene (125645). Dilated cardiomyopathy with woolly hair, keratoderma, and tooth agenesis (DCWHKTA; 615821) is caused by heterozygous mutation in DSP. An isolated form of striated PPK (PPKS2; 612908) is also caused by heterozygous mutation in DSP. Reviews In a review of cardiocutaneous syndromes and arrhythmogenic cardiomyopathy, Sen-Chowdhry and McKenna (2014) stated that although the cardiac component of Carvajal syndrome was originally considered dilated cardiomyopathy, many of its features resemble those of arrhythmogenic cardiomyopathy (see 607450). In addition, they noted that different disease subtypes have been found to coexist within the same kindred, suggesting a role for modifier genes and/or environmental influences.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/340124">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_410143"><div><strong>Tooth agenesis, selective, X-linked, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>410143</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1970757</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any tooth agenesis in which the cause of the disease is a mutation in the EDA gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/410143">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_862830"><div><strong>Cardiomyopathy, dilated, with wooly hair, keratoderma, and tooth agenesis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862830</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014393</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Keratoderma with woolly hair is a group of related conditions that affect the skin and hair and in many cases increase the risk of potentially life-threatening heart problems. People with these conditions have hair that is unusually coarse, dry, fine, and tightly curled. In some cases, the hair is also sparse. The woolly hair texture typically affects only scalp hair and is present from birth. Starting early in life, affected individuals also develop palmoplantar keratoderma, a condition that causes skin on the palms of the hands and the soles of the feet to become thick, scaly, and calloused.\n\nCardiomyopathy, which is a disease of the heart muscle, is a life-threatening health problem that can develop in people with keratoderma with woolly hair. Unlike the other features of this condition, signs and symptoms of cardiomyopathy may not appear until adolescence or later. Complications of cardiomyopathy can include an abnormal heartbeat (arrhythmia), heart failure, and sudden death.\n\nKeratoderma with woolly hair comprises several related conditions with overlapping signs and symptoms. Researchers have recently proposed classifying keratoderma with woolly hair into four types, based on the underlying genetic cause. Type I, also known as Naxos disease, is characterized by palmoplantar keratoderma, woolly hair, and a form of cardiomyopathy called arrhythmogenic right ventricular cardiomyopathy (ARVC). Type II, also known as Carvajal syndrome, has hair and skin abnormalities similar to type I but features a different form of cardiomyopathy, called dilated left ventricular cardiomyopathy. Type III also has signs and symptoms similar to those of type I, including ARVC, although the hair and skin abnormalities are often milder. Type IV is characterized by palmoplantar keratoderma and woolly and sparse hair, as well as abnormal fingernails and toenails. Type IV does not appear to cause cardiomyopathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/862830">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_864047"><div><strong>Osteogenesis imperfecta type 16</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>864047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015610</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteogenesis imperfecta type XVI (OI16) is characterized by prenatal onset of multiple fractures of ribs and long bones, blue sclerae, decreased ossification of the skull, and severe demineralization. Heterozygous family members may exhibit recurrent fractures with minimal trauma, osteopenia, and blue sclerae (Keller et al., 2018; Lindahl et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/864047">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1623594"><div><strong>Blepharocheilodontic syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1623594</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540127</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Blepharocheilodontic (BCD) syndrome is a disorder that is present at birth. It mainly affects the eyelids (blepharo-), upper lip (-cheilo-), and teeth (-dontic).\n\nOccasionally people with BCD syndrome have additional features, including an obstruction of the anal opening (imperforate anus); malformation or absence of the butterfly-shaped gland in the lower neck called the thyroid, resulting in lack of thyroid gland function; or fused fingers or toes (syndactyly). Very rarely, affected individuals have incompletely formed arms or legs (limb reduction defects) or a spinal cord abnormality known as spina bifida.\n\nPeople with BCD syndrome have lower eyelids that turn out so that the inner surface is exposed (ectropion). The outside of the lower lid may sag away from the eye (euryblepharon), and the eyelids may not be able to close completely (lagophthalmia). There can be extra eyelashes (distichiasis) on the upper eyelids, ranging from a few extra eyelashes to a full extra set. These eyelashes do not grow along the edge of the eyelid with the normal lashes, but out of its inner lining. When the abnormal eyelashes touch the eyeball, they can cause damage to the clear covering of the eye (cornea). Affected individuals may also have widely spaced eyes (hypertelorism), a flat face, and a high forehead.\n\nOther features of BCD syndrome usually include openings on both sides of the upper lip (bilateral cleft lip) and an opening in the roof of the mouth (cleft palate). Affected individuals may have fewer teeth than normal (oligodontia) and their teeth are often smaller than usual and cone-shaped. The dental abnormalities affect both primary teeth (sometimes called "baby teeth") and secondary (permanent) teeth. Other frequent features include sparse, fine hair and abnormal nails.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1623594">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1676818"><div><strong>Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1676818</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193055</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis (SSASKS)is characterized by disproportionate short stature, defective tooth enamel formation, and skeletal dysplasia with severe scoliosis in some patients. Variable features include facial dysmorphism, moderate hearing impairment, and mildly impaired intellectual development (Ashikov et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1676818">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1684772"><div><strong>Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684772</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231481</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1684772">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1770070"><div><strong>Autosomal recessive Robinow syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1770070</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399974</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">ROR2-related Robinow syndrome is characterized by distinctive craniofacial features, skeletal abnormalities, and other anomalies. Craniofacial features include macrocephaly, broad prominent forehead, low-set ears, ocular hypertelorism, prominent eyes, midface hypoplasia, short upturned nose with depressed nasal bridge and flared nostrils, large and triangular mouth with exposed incisors and upper gums, gum hypertrophy, misaligned teeth, ankyloglossia, and micrognathia. Skeletal abnormalities include short stature, mesomelic or acromesomelic limb shortening, hemivertebrae with fusion of thoracic vertebrae, and brachydactyly. Other common features include micropenis with or without cryptorchidism in males and reduced clitoral size and hypoplasia of the labia majora in females, renal tract abnormalities, and nail hypoplasia or dystrophy. The disorder is recognizable at birth or in early childhood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1770070">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_340124" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Arrhythmogenic cardiomyopathy with wooly hair and keratoderma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1770070" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive Robinow syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1623594" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Blepharocheilodontic syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862830" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardiomyopathy, dilated, with wooly hair, keratoderma, and tooth agenesis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333092" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphyseal dysplasia, multiple, 2</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (11)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_289648" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 2 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684772" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with brain anomalies and with or without vertebral or cardiac anomalies</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_864047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteogenesis imperfecta type 16</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1676818" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Short stature, amelogenesis imperfecta, and skeletal dysplasia with scoliosis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_372057" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tooth agenesis, selective, 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_410143" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tooth agenesis, selective, X-linked, 1</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37184613">The phenotype and genotype of PAX9 mutations causing tooth agenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang C,
|
||
Yu K,
|
||
Shen Y,
|
||
Wang F,
|
||
Dai Q,
|
||
Wu Y</span><br />
|
||
<span class="medgenPMjournal">Clin Oral Investig</span>
|
||
2023 Aug;27(8):4369-4378.
|
||
Epub 2023 May 15
|
||
doi: 10.1007/s00784-023-05056-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37184613" target="_blank">37184613</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28401166">Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Ani AH,
|
||
Antoun JS,
|
||
Thomson WM,
|
||
Merriman TR,
|
||
Farella M</span><br />
|
||
<span class="medgenPMjournal">Biomed Res Int</span>
|
||
2017;2017:9378325.
|
||
Epub 2017 Mar 19
|
||
doi: 10.1155/2017/9378325.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28401166" target="_blank">28401166</a><a href="/pmc/articles/PMC5376450" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22452934">Dentistry and molecular biology: a promising field for tooth agenesis management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boeira Junior BR,
|
||
Echeverrigaray S</span><br />
|
||
<span class="medgenPMjournal">Tohoku J Exp Med</span>
|
||
2012 Apr;226(4):243-9.
|
||
doi: 10.1620/tjem.226.243.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22452934" target="_blank">22452934</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22tooth%20agenesis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (23)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39383567">Familial hypodontia in bronze age Northwest China (1046-771BC).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu Y,
|
||
Ma Q,
|
||
Han B,
|
||
Shen Y,
|
||
Wen S</span><br />
|
||
<span class="medgenPMjournal">Arch Oral Biol</span>
|
||
2025 Jan;169:106104.
|
||
Epub 2024 Oct 2
|
||
doi: 10.1016/j.archoralbio.2024.106104.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39383567" target="_blank">39383567</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38488796">Congenital Tooth Agenesis and Risk of Early-Onset Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eiset SE,
|
||
Schraw J,
|
||
Sørensen GV,
|
||
Gregersen PA,
|
||
Rasmussen SA,
|
||
Ramlau-Hansen CH,
|
||
Lupo PJ,
|
||
Hasle H</span><br />
|
||
<span class="medgenPMjournal">JAMA Netw Open</span>
|
||
2024 Mar 4;7(3):e240365.
|
||
doi: 10.1001/jamanetworkopen.2024.0365.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38488796" target="_blank">38488796</a><a href="/pmc/articles/PMC10943407" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36860143">AXIN2-related oligodontia-colorectal cancer syndrome with cleft palate as a possible new feature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roht L,
|
||
Hyldebrandt HK,
|
||
Stormorken AT,
|
||
Nordgarden H,
|
||
Sijmons RH,
|
||
Bos DK,
|
||
Riegert-Johnson D,
|
||
Mantia-Macklin S,
|
||
Ilves P,
|
||
Muru K,
|
||
Wojcik MH,
|
||
Kahre T,
|
||
Õunap K</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Genomic Med</span>
|
||
2023 Jun;11(6):e2157.
|
||
Epub 2023 Mar 1
|
||
doi: 10.1002/mgg3.2157.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36860143" target="_blank">36860143</a><a href="/pmc/articles/PMC10265056" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29500156">Rethinking isolated cleft lip and palate as a syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koruyucu M,
|
||
Kasimoğlu Y,
|
||
Seymen F,
|
||
Bayram M,
|
||
Patir A,
|
||
Ergöz N,
|
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<div class="nl"><a target="_blank" href="/pubmed/30759978">Tooth agenesis: part 1. Incidence and diagnosis in orthodontics.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/9603237">Neuro-osteology.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tooth%20agenesis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (142)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39383567">Familial hypodontia in bronze age Northwest China (1046-771BC).</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wu Y,
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<span class="bold">PMID: </span><a href="/pubmed/39383567" target="_blank">39383567</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fonseca-Souza G,
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Wambier LM,
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Scariot R,
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<span class="bold">PMID: </span><a href="/pubmed/35729285" target="_blank">35729285</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35714441">Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Liu H,
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<span class="bold">PMID: </span><a href="/pubmed/35714441" target="_blank">35714441</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33249565">Tooth agenesis: What do we know and is there a connection to cancer?</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bonczek O,
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Krejci P,
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<span class="bold">PMID: </span><a href="/pubmed/33249565" target="_blank">33249565</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30759978">Tooth agenesis: part 1. Incidence and diagnosis in orthodontics.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">De Santis D,
|
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Pancera P,
|
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Sinigaglia S,
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Faccioni P,
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Albanese M,
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Bertossi D,
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Luciano U,
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Zotti F,
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Matarese M,
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Lucchese A,
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Croce S,
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Donadello D,
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Ricciardi G,
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Kumar N,
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Nocini R,
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Nocini P F</span><br />
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<span class="medgenPMjournal">J Biol Regul Homeost Agents</span>
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<span class="bold">PMID: </span><a href="/pubmed/30759978" target="_blank">30759978</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28401166">Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Al-Ani AH,
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Antoun JS,
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Thomson WM,
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Merriman TR,
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Farella M</span><br />
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<span class="medgenPMjournal">Biomed Res Int</span>
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Epub 2017 Mar 19
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<span class="bold">PMID: </span><a href="/pubmed/28401166" target="_blank">28401166</a><a href="/pmc/articles/PMC5376450" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9603237">Neuro-osteology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaer I</span><br />
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<span class="medgenPMjournal">Crit Rev Oral Biol Med</span>
|
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1998;9(2):224-44.
|
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doi: 10.1177/10454411980090020501.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9603237" target="_blank">9603237</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tooth%20agenesis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (90)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39383567">Familial hypodontia in bronze age Northwest China (1046-771BC).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu Y,
|
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Ma Q,
|
||
Han B,
|
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Shen Y,
|
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Wen S</span><br />
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<span class="medgenPMjournal">Arch Oral Biol</span>
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2025 Jan;169:106104.
|
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Epub 2024 Oct 2
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doi: 10.1016/j.archoralbio.2024.106104.
|
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<span class="bold">PMID: </span><a href="/pubmed/39383567" target="_blank">39383567</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36982827">Genetic/Protein Association of Atopic Dermatitis and Tooth Agenesis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ouyang W,
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Goh CE,
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Ng WB,
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Chew FT,
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Yap EPH,
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Hsu CS</span><br />
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<span class="medgenPMjournal">Int J Mol Sci</span>
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2023 Mar 17;24(6)
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<span class="bold">PMID: </span><a href="/pubmed/36982827" target="_blank">36982827</a><a href="/pmc/articles/PMC10055628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35714441">Novel DLX3 variant identified in a family with tricho-dento-osseous syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu H,
|
||
Wang Y,
|
||
Liu H,
|
||
Yu M,
|
||
Zheng J,
|
||
Feng H,
|
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Liu Y,
|
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Han D</span><br />
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<span class="medgenPMjournal">Arch Oral Biol</span>
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2022 Sep;141:105479.
|
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Epub 2022 Jun 10
|
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doi: 10.1016/j.archoralbio.2022.105479.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35714441" target="_blank">35714441</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33249565">Tooth agenesis: What do we know and is there a connection to cancer?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bonczek O,
|
||
Krejci P,
|
||
Izakovicova-Holla L,
|
||
Cernochova P,
|
||
Kiss I,
|
||
Vojtesek B</span><br />
|
||
<span class="medgenPMjournal">Clin Genet</span>
|
||
2021 Apr;99(4):493-502.
|
||
Epub 2021 Feb 16
|
||
doi: 10.1111/cge.13892.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33249565" target="_blank">33249565</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28401166">Hypodontia: An Update on Its Etiology, Classification, and Clinical Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Ani AH,
|
||
Antoun JS,
|
||
Thomson WM,
|
||
Merriman TR,
|
||
Farella M</span><br />
|
||
<span class="medgenPMjournal">Biomed Res Int</span>
|
||
2017;2017:9378325.
|
||
Epub 2017 Mar 19
|
||
doi: 10.1155/2017/9378325.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28401166" target="_blank">28401166</a><a href="/pmc/articles/PMC5376450" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tooth%20agenesis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (233)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/35729285">Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fonseca-Souza G,
|
||
de Oliveira LB,
|
||
Wambier LM,
|
||
Scariot R,
|
||
Feltrin-Souza J</span><br />
|
||
<span class="medgenPMjournal">Clin Oral Investig</span>
|
||
2022 Aug;26(8):5089-5103.
|
||
Epub 2022 Jun 21
|
||
doi: 10.1007/s00784-022-04540-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35729285" target="_blank">35729285</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34378652">Association between tooth agenesis and cancer: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Medina MCG,
|
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Bastos RTDRM,
|
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Mecenas P,
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Pinheiro JJV,
|
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Normando D</span><br />
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<span class="medgenPMjournal">J Appl Oral Sci</span>
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2021;29:e20200955.
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Epub 2021 Aug 9
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doi: 10.1590/1678-7757-2020-0955.
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||
<span class="bold">PMID: </span><a href="/pubmed/34378652" target="_blank">34378652</a><a href="/pmc/articles/PMC8360625" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31909464">Coexistence of tooth agenesis and ovarian cancer - a systematic literature review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gawron-Jakubek W,
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Spaczynska J,
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Pitynski K,
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Loster BW</span><br />
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<span class="medgenPMjournal">Ginekol Pol</span>
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2019;90(12):707-710.
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<span class="bold">PMID: </span><a href="/pubmed/31909464" target="_blank">31909464</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29027749">Permanent tooth agenesis in individuals with non-syndromic Robin sequence: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Antonarakis GS,
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Palaska PK,
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Suri S</span><br />
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<span class="medgenPMjournal">Orthod Craniofac Res</span>
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2017 Nov;20(4):216-226.
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Epub 2017 Oct 13
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<span class="bold">PMID: </span><a href="/pubmed/29027749" target="_blank">29027749</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/27699475">Tooth agenesis and orofacial clefting: genetic brothers in arms?</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Phan M,
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Conte F,
|
||
Khandelwal KD,
|
||
Ockeloen CW,
|
||
Bartzela T,
|
||
Kleefstra T,
|
||
van Bokhoven H,
|
||
Rubini M,
|
||
Zhou H,
|
||
Carels CE</span><br />
|
||
<span class="medgenPMjournal">Hum Genet</span>
|
||
2016 Dec;135(12):1299-1327.
|
||
Epub 2016 Oct 3
|
||
doi: 10.1007/s00439-016-1733-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27699475" target="_blank">27699475</a><a href="/pmc/articles/PMC5065589" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tooth%20agenesis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C4024202%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (26)</a></li>
|
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<li><a href="/gtr/tests?term=C4024202%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (26)</a></li>
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