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<meta name="keywords" content="C4022950, abnormal homeostasis, finding, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An anomaly in the processes involved in the maintenance of an internal equilibrium." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Abnormal homeostasis (Concept Id: C4022950)
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<!--
UID=868551
ConceptID=C4022950
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormal homeostasis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868551</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4022950</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0012337">HP:0012337</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An anomaly in the processes involved in the maintenance of an internal equilibrium. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Abnormal homeostasis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="matched_ds">Abnormal homeostasis</span><ul><li><span class="TLline"><a href="/medgen/868550" ref="tree=MeSH" title="MedGen record for Abnormal energy expenditure">Abnormal energy expenditure</a></span><ul><li><span class="TLline"><a href="/medgen/868548" ref="tree=MeSH" title="MedGen record for Decreased resting energy expenditure">Decreased resting energy expenditure</a></span></li><li><span class="TLline"><a href="/medgen/868549" ref="tree=MeSH" title="MedGen record for Increased resting energy expenditure">Increased resting energy expenditure</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/869176" ref="tree=MeSH" title="MedGen record for Abnormal glucose homeostasis">Abnormal glucose homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/869175" ref="tree=MeSH" title="MedGen record for Abnormal blood glucose concentration">Abnormal blood glucose concentration</a></span><ul><li><span class="TLline"><a href="/medgen/5689" ref="tree=MeSH" title="MedGen record for Hyperglycemia">Hyperglycemia</a></span></li><li><span class="TLline"><a href="/medgen/6979" ref="tree=MeSH" title="MedGen record for Hypoglycemia">Hypoglycemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1864109" ref="tree=MeSH" title="MedGen record for Failure to elevate lactate upon ischemic exercise test">Failure to elevate lactate upon ischemic exercise test</a></span></li><li><span class="TLline"><a href="/medgen/75760" ref="tree=MeSH" title="MedGen record for Glucose intolerance">Glucose intolerance</a></span><ul><li><span class="TLline"><a href="/medgen/8350" ref="tree=MeSH" title="MedGen record for Diabetes mellitus">Diabetes mellitus</a></span></li><li><span class="TLline"><a href="/medgen/852424" ref="tree=MeSH" title="MedGen record for Impaired glucose tolerance">Impaired glucose tolerance</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/480966" ref="tree=MeSH" title="MedGen record for Impaired gluconeogenesis">Impaired gluconeogenesis</a></span></li><li><span class="TLline"><a href="/medgen/1635847" ref="tree=MeSH" title="MedGen record for Increased proinsulin:insulin ratio">Increased proinsulin:insulin ratio</a></span></li><li><span class="TLline"><a href="/medgen/350460" ref="tree=MeSH" title="MedGen record for Insulin insensitivity">Insulin insensitivity</a></span></li><li><span class="TLline"><a href="/medgen/43904" ref="tree=MeSH" title="MedGen record for Insulin resistance">Insulin resistance</a></span><ul><li><span class="TLline"><a href="/medgen/163439" ref="tree=MeSH" title="MedGen record for Insulin-resistant diabetes mellitus">Insulin-resistant diabetes mellitus</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/868032" ref="tree=MeSH" title="MedGen record for Abnormal sweat homeostasis">Abnormal sweat homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/868031" ref="tree=MeSH" title="MedGen record for Abnormal sweat electrolytes">Abnormal sweat electrolytes</a></span></li><li><span class="TLline"><a href="/medgen/347278" ref="tree=MeSH" title="MedGen record for Elevated sweat chloride">Elevated sweat chloride</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/7851" ref="tree=MeSH" title="MedGen record for Abnormality of acid-base homeostasis">Abnormality of acid-base homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1675003" ref="tree=MeSH" title="MedGen record for Abnormal base excess">Abnormal base excess</a></span></li><li><span class="TLline"><a href="/medgen/1671081" ref="tree=MeSH" title="MedGen record for Abnormal serum anion gap">Abnormal serum anion gap</a></span><ul><li><span class="TLline"><a href="/medgen/1670952" ref="tree=MeSH" title="MedGen record for Decreased serum anion gap">Decreased serum anion gap</a></span></li><li><span class="TLline"><a href="/medgen/1671031" ref="tree=MeSH" title="MedGen record for Elevated serum anion gap">Elevated serum anion gap</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1671084" ref="tree=MeSH" title="MedGen record for Abnormal serum bicarbonate concentration">Abnormal serum bicarbonate concentration</a></span><ul><li><span class="TLline"><a href="/medgen/1670967" ref="tree=MeSH" title="MedGen record for Decreased serum bicarbonate concentration">Decreased serum bicarbonate concentration</a></span></li><li><span class="TLline"><a href="/medgen/1671049" ref="tree=MeSH" title="MedGen record for Elevated serum bicarbonate concentration">Elevated serum bicarbonate concentration</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1714" ref="tree=MeSH" title="MedGen record for Achlorhydria">Achlorhydria</a></span></li><li><span class="TLline"><a href="/medgen/541142" ref="tree=MeSH" title="MedGen record for Acidemia">Acidemia</a></span><ul><li><span class="TLline"><a href="/medgen/868025" ref="tree=MeSH" title="MedGen record for Dicarboxylic acidemia">Dicarboxylic acidemia</a></span></li><li><span class="TLline"><a href="/medgen/871132" ref="tree=MeSH" title="MedGen record for Elevated circulating glutaric acid concentration">Elevated circulating glutaric acid concentration</a></span></li><li><span class="TLline"><a href="/medgen/120654" ref="tree=MeSH" title="MedGen record for Methylmalonic 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dehydration</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/4451" ref="tree=MeSH" title="MedGen record for Edema">Edema</a></span><ul><li><span class="TLline"><a href="/medgen/101794" ref="tree=MeSH" title="MedGen record for Anasarca">Anasarca</a></span></li><li><span class="TLline"><a href="/medgen/4452" ref="tree=MeSH" title="MedGen record for Cardiac edema">Cardiac edema</a></span></li><li><span class="TLline"><a href="/medgen/2337" ref="tree=MeSH" title="MedGen record for Cerebral edema">Cerebral edema</a></span></li><li><span class="TLline"><a href="/medgen/124393" ref="tree=MeSH" title="MedGen record for Chemosis">Chemosis</a></span></li><li><span class="TLline"><a href="/medgen/1056896" ref="tree=MeSH" title="MedGen record for Clavicular edema">Clavicular edema</a></span></li><li><span class="TLline"><a href="/medgen/3242" ref="tree=MeSH" title="MedGen record for corneal edema">corneal edema</a></span></li><li><span class="TLline"><a href="/medgen/752076" ref="tree=MeSH" title="MedGen record for Edema of the dorsum of hands">Edema of the dorsum of hands</a></span></li><li><span class="TLline"><a href="/medgen/108296" ref="tree=MeSH" title="MedGen record for Edema of trunk">Edema of trunk</a></span></li><li><span class="TLline"><a href="/medgen/154241" ref="tree=MeSH" title="MedGen record for Facial edema">Facial edema</a></span></li><li><span class="TLline"><a href="/medgen/376817" ref="tree=MeSH" title="MedGen record for Generalized edema">Generalized edema</a></span></li><li><span class="TLline"><a href="/medgen/101795" ref="tree=MeSH" title="MedGen record for Genital edema">Genital edema</a></span></li><li><span class="TLline"><a href="/medgen/6947" ref="tree=MeSH" title="MedGen record for Hydrops fetalis">Hydrops fetalis</a></span></li><li><span class="TLline"><a href="/medgen/320555" ref="tree=MeSH" title="MedGen record for Hyperkeratosis over edematous areas">Hyperkeratosis over edematous areas</a></span></li><li><span class="TLline"><a href="/medgen/870387" ref="tree=MeSH" title="MedGen record for Hypoproteinemic edema">Hypoproteinemic edema</a></span></li><li><span class="TLline"><a href="/medgen/6017" ref="tree=MeSH" title="MedGen record for Laryngeal edema">Laryngeal edema</a></span></li><li><span class="TLline"><a href="/medgen/4453" ref="tree=MeSH" title="MedGen record for Localized edema">Localized edema</a></span></li><li><span class="TLline"><a href="/medgen/6155" ref="tree=MeSH" title="MedGen record for Lymphedema">Lymphedema</a></span></li><li><span class="TLline"><a href="/medgen/66012" ref="tree=MeSH" title="MedGen record for Neck Edema">Neck Edema</a></span></li><li><span class="TLline"><a href="/medgen/224749" ref="tree=MeSH" title="MedGen record for Non-pitting edema">Non-pitting edema</a></span></li><li><span class="TLline"><a href="/medgen/10565" ref="tree=MeSH" title="MedGen record for Optic papillitis">Optic papillitis</a></span></li><li><span class="TLline"><a href="/medgen/98085" ref="tree=MeSH" title="MedGen record for Peau d'orange">Peau d'orange</a></span></li><li><span class="TLline"><a href="/medgen/56223" ref="tree=MeSH" title="MedGen record for Periorbital edema">Periorbital edema</a></span></li><li><span class="TLline"><a href="/medgen/39321" ref="tree=MeSH" title="MedGen record for Peripheral edema">Peripheral edema</a></span></li><li><span class="TLline"><a href="/medgen/137681" ref="tree=MeSH" title="MedGen record for Pitting edema">Pitting edema</a></span></li><li><span class="TLline"><a href="/medgen/508785" ref="tree=MeSH" title="MedGen record for Tongue edema">Tongue edema</a></span></li><li><span class="TLline"><a href="/medgen/442997" ref="tree=MeSH" title="MedGen record for Vasogenic Edema">Vasogenic Edema</a></span></li><li><span class="TLline"><a href="/medgen/305584" ref="tree=MeSH" title="MedGen record for Visceral Edema">Visceral Edema</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/330395" ref="tree=MeSH" title="MedGen record for Abnormality of temperature regulation">Abnormality of temperature regulation</a></span><ul><li><span class="TLline"><a href="/medgen/507579" ref="tree=MeSH" title="MedGen record for Cold intolerance">Cold intolerance</a></span></li><li><span class="TLline"><a href="/medgen/5169" ref="tree=MeSH" title="MedGen record for Fever">Fever</a></span><ul><li><span class="TLline"><a href="/medgen/472972" ref="tree=MeSH" title="MedGen record for High Grade Fever">High Grade Fever</a></span></li><li><span class="TLline"><a href="/medgen/581221" ref="tree=MeSH" title="MedGen record for Hyperpyrexia">Hyperpyrexia</a></span></li><li><span class="TLline"><a href="/medgen/82922" ref="tree=MeSH" title="MedGen record for Intermittent fever">Intermittent fever</a></span></li><li><span class="TLline"><a href="/medgen/822262" ref="tree=MeSH" title="MedGen record for Intrapartum fever">Intrapartum fever</a></span></li><li><span class="TLline"><a href="/medgen/116089" ref="tree=MeSH" title="MedGen record for Low-grade fever">Low-grade fever</a></span></li><li><span class="TLline"><a href="/medgen/1783587" ref="tree=MeSH" title="MedGen record for Moderate Grade Fever">Moderate Grade Fever</a></span></li><li><span class="TLline"><a href="/medgen/1720688" ref="tree=MeSH" title="MedGen record for Persistent fever">Persistent fever</a></span></li><li><span class="TLline"><a href="/medgen/730326" ref="tree=MeSH" title="MedGen record for Puerperal pyrexia">Puerperal pyrexia</a></span></li><li><span class="TLline"><a href="/medgen/42012" ref="tree=MeSH" title="MedGen record for Pyrexia of unknown origin">Pyrexia of unknown origin</a></span></li><li><span class="TLline"><a href="/medgen/811468" ref="tree=MeSH" title="MedGen record for Recurrent fever">Recurrent fever</a></span></li><li><span class="TLline"><a href="/medgen/116681" ref="tree=MeSH" title="MedGen record for Sickness, Sweating">Sickness, Sweating</a></span></li><li><span class="TLline"><a href="/medgen/1747542" ref="tree=MeSH" title="MedGen record for Subjective Fever">Subjective Fever</a></span></li><li><span class="TLline"><a href="/medgen/11681" ref="tree=MeSH" title="MedGen record for Sweating fever">Sweating fever</a></span></li><li><span class="TLline"><a href="/medgen/182683" ref="tree=MeSH" title="MedGen record for Tumor Associated Fever">Tumor Associated Fever</a></span></li><li><span class="TLline"><a href="/medgen/337055" ref="tree=MeSH" title="MedGen record for Unexplained fevers">Unexplained fevers</a></span></li><li><span class="TLline"><a href="/medgen/9213" ref="tree=MeSH" title="MedGen record for Viral hemorrhagic fever">Viral hemorrhagic fever</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/66659" ref="tree=MeSH" title="MedGen record for Heat intolerance">Heat intolerance</a></span></li><li><span class="TLline"><a href="/medgen/5720" ref="tree=MeSH" title="MedGen record for Hypothermia">Hypothermia</a></span><ul><li><span class="TLline"><a href="/medgen/332504" ref="tree=MeSH" title="MedGen record for Intermittent hypothermia">Intermittent hypothermia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1745742" ref="tree=MeSH" title="MedGen record for Inappropriate absence of fever">Inappropriate absence of fever</a></span></li><li><span class="TLline"><a href="/medgen/1830388" ref="tree=MeSH" title="MedGen record for Malignant hyperthermia">Malignant hyperthermia</a></span><ul><li><span class="TLline"><a href="/medgen/1814609" ref="tree=MeSH" title="MedGen record for Exercise-induced malignant hyperthermia">Exercise-induced malignant hyperthermia</a></span></li><li><span class="TLline"><a href="/medgen/1624011" ref="tree=MeSH" title="MedGen record for Exercise-triggered malignant hyperthermia">Exercise-triggered malignant hyperthermia</a></span></li><li><span class="TLline"><a href="/medgen/9867" ref="tree=MeSH" title="MedGen record for Malignant hyperthermia of anesthesia">Malignant hyperthermia of anesthesia</a></span></li><li><span class="TLline"><a href="/medgen/1728755" ref="tree=MeSH" title="MedGen record for Malignant hyperthermia, susceptibility to">Malignant hyperthermia, susceptibility to</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/329973" ref="tree=MeSH" title="MedGen record for Temperature instability">Temperature instability</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/871171" ref="tree=MeSH" title="MedGen record for Excessive purine production">Excessive purine production</a></span></li><li><span class="TLline"><a href="/medgen/57440" ref="tree=MeSH" title="MedGen record for Food intolerance">Food intolerance</a></span><ul><li><span class="TLline"><a href="/medgen/234665" ref="tree=MeSH" title="MedGen record for Intolerance to protein">Intolerance to protein</a></span><ul><li><span class="TLline"><a href="/medgen/1370572" ref="tree=MeSH" title="MedGen record for Gluten intolerance">Gluten intolerance</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1863672" ref="tree=MeSH" title="MedGen record for Inappropriately low concentration of acetoacetate">Inappropriately low concentration of acetoacetate</a></span></li><li><span class="TLline"><a href="/medgen/1863840" ref="tree=MeSH" title="MedGen record for Inappropriately low concentration of beta-hydroxybutyrate">Inappropriately low concentration of beta-hydroxybutyrate</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34309815">Increasing numbers of CD19+CD24(high)CD38(high) regulatory B cells and pre-germinal center B cells reflect activated autoimmunity and predict future treatment response in patients with untreated immune thrombocytopenia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hayashi T,
Nakamae H,
Takeda S,
Nakashima Y,
Koh H,
Nishimoto M,
Okamura H,
Nanno S,
Makuuchi Y,
Kuno M,
Nakamae M,
Hirose A,
Hino M</span><br />
<span class="medgenPMjournal">Int J Hematol</span>
2021 Nov;114(5):580-590.
Epub 2021 Jul 26
doi: 10.1007/s12185-021-03192-w.
<span class="bold">PMID: </span><a href="/pubmed/34309815" target="_blank">34309815</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6253520">Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Drezner MK,
Lyles KW,
Haussler MR,
Harrelson JM</span><br />
<span class="medgenPMjournal">J Clin Invest</span>
1980 Nov;66(5):1020-32.
doi: 10.1172/JCI109930.
<span class="bold">PMID: </span><a href="/pubmed/6253520" target="_blank">6253520</a><a href="/pmc/articles/PMC371539" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22abnormal%20homeostasis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/39486274">Porphyromonas gingivalis-induced autophagy exacerbates abnormal lung homeostasis: An in vivo and in vitro study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao Q,
Li W,
Li W,
Yang H,
Wang X,
Ding Z,
Liu Z,
Wang Z</span><br />
<span class="medgenPMjournal">Arch Oral Biol</span>
2025 Jan;169:106122.
Epub 2024 Oct 29
doi: 10.1016/j.archoralbio.2024.106122.
<span class="bold">PMID: </span><a href="/pubmed/39486274" target="_blank">39486274</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32203449">Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsuoka M,
Inoue T,
Shinjo T,
Miiji A,
Tamashiro M,
Oba K,
Arima H,
Arasaki O</span><br />
<span class="medgenPMjournal">Hypertens Res</span>
2020 Aug;43(8):817-823.
Epub 2020 Mar 17
doi: 10.1038/s41440-020-0427-z.
<span class="bold">PMID: </span><a href="/pubmed/32203449" target="_blank">32203449</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24222606">Blood metals concentration in type 1 and type 2 diabetics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Forte G,
Bocca B,
Peruzzu A,
Tolu F,
Asara Y,
Farace C,
Oggiano R,
Madeddu R</span><br />
<span class="medgenPMjournal">Biol Trace Elem Res</span>
2013 Dec;156(1-3):79-90.
Epub 2013 Nov 14
doi: 10.1007/s12011-013-9858-6.
<span class="bold">PMID: </span><a href="/pubmed/24222606" target="_blank">24222606</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23659624">The role of cytokines in skin aging.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Borg M,
Brincat S,
Camilleri G,
Schembri-Wismayer P,
Brincat M,
Calleja-Agius J</span><br />
<span class="medgenPMjournal">Climacteric</span>
2013 Oct;16(5):514-21.
Epub 2013 May 31
doi: 10.3109/13697137.2013.802303.
<span class="bold">PMID: </span><a href="/pubmed/23659624" target="_blank">23659624</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17652877">Smoking and aortic diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kakafika AI,
Mikhailidis DP</span><br />
<span class="medgenPMjournal">Circ J</span>
2007 Aug;71(8):1173-80.
doi: 10.1253/circj.71.1173.
<span class="bold">PMID: </span><a href="/pubmed/17652877" target="_blank">17652877</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20homeostasis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35786848">An Autocatalytic DNA Circuit Based on Hybridization Chain Assembly for Intracellular Imaging of Polynucleotide Kinase.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wang Y,
Chen Y,
Wan Y,
Hong C,
Shang J,
Li F,
Liu X,
Wang F</span><br />
<span class="medgenPMjournal">ACS Appl Mater Interfaces</span>
2022 Jul 20;14(28):31727-31736.
Epub 2022 Jul 5
doi: 10.1021/acsami.2c08523.
<span class="bold">PMID: </span><a href="/pubmed/35786848" target="_blank">35786848</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32203449">Cardiovascular risk profile and frailty in Japanese outpatients: the Nambu Cohort Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsuoka M,
Inoue T,
Shinjo T,
Miiji A,
Tamashiro M,
Oba K,
Arima H,
Arasaki O</span><br />
<span class="medgenPMjournal">Hypertens Res</span>
2020 Aug;43(8):817-823.
Epub 2020 Mar 17
doi: 10.1038/s41440-020-0427-z.
<span class="bold">PMID: </span><a href="/pubmed/32203449" target="_blank">32203449</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25556818">Fluorescence imaging of metal ions implicated in diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Qian X,
Xu Z</span><br />
<span class="medgenPMjournal">Chem Soc Rev</span>
2015 Jul 21;44(14):4487-93.
doi: 10.1039/c4cs00292j.
<span class="bold">PMID: </span><a href="/pubmed/25556818" target="_blank">25556818</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17211243">Endothelial dysfunction and cardiovascular risk profile in long-term withdrawing alcoholics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Di Gennaro C,
Biggi A,
Barilli AL,
Fasoli E,
Carra N,
Novarini A,
Delsignore R,
Montanari A</span><br />
<span class="medgenPMjournal">J Hypertens</span>
2007 Feb;25(2):367-73.
doi: 10.1097/HJH.0b013e328010929c.
<span class="bold">PMID: </span><a href="/pubmed/17211243" target="_blank">17211243</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12490832">Can we distinguish anxiety from depression?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Baldwin DS,
Evans DL,
Hirschfeld RM,
Kasper S</span><br />
<span class="medgenPMjournal">Psychopharmacol Bull</span>
2002 Summer;36 Suppl 2:158-65.
<span class="bold">PMID: </span><a href="/pubmed/12490832" target="_blank">12490832</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20homeostasis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38809370">Recent Advances in Targeting Transition Metals (Copper, Iron, and Zinc) in Alzheimer's Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Singh R,
Panghal A,
Jadhav K,
Thakur A,
Verma RK,
Singh C,
Goyal M,
Kumar J,
Namdeo AG</span><br />
<span class="medgenPMjournal">Mol Neurobiol</span>
2024 Dec;61(12):10916-10940.
Epub 2024 May 29
doi: 10.1007/s12035-024-04256-8.
<span class="bold">PMID: </span><a href="/pubmed/38809370" target="_blank">38809370</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24222606">Blood metals concentration in type 1 and type 2 diabetics.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Forte G,
Bocca B,
Peruzzu A,
Tolu F,
Asara Y,
Farace C,
Oggiano R,
Madeddu R</span><br />
<span class="medgenPMjournal">Biol Trace Elem Res</span>
2013 Dec;156(1-3):79-90.
Epub 2013 Nov 14
doi: 10.1007/s12011-013-9858-6.
<span class="bold">PMID: </span><a href="/pubmed/24222606" target="_blank">24222606</a></div>
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2013 Oct;16(5):514-21.
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2007 Aug;71(8):1173-80.
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2006 Jan 19;354(3):241-50.
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Nakashima Y,
Koh H,
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Okamura H,
Nanno S,
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Wohlfahrt P,
Cífková R,
Windrichová J,
Knapen MH,
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