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<!--
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||
UID=866762
|
||
ConceptID=C4021113
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormal T cell count</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866762</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4021113</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Abnormality of T cell count</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011839">HP:0011839</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A deviation from the normal count of T cells. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Abnormal T cell count</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867388" ref="tree=MeSH" title="MedGen record for Abnormality of the immune system">Abnormality of the immune system</a></span><ul><li><span class="TLline"><a href="/medgen/1702861" ref="tree=MeSH" title="MedGen record for Abnormal immune system morphology">Abnormal immune system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/869190" ref="tree=MeSH" title="MedGen record for Abnormal cellular immune system morphology">Abnormal cellular immune system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/508852" ref="tree=MeSH" title="MedGen record for Abnormal leukocyte morphology">Abnormal leukocyte morphology</a></span><ul><li><span class="TLline"><a href="/medgen/488926" ref="tree=MeSH" title="MedGen record for Abnormal leukocyte count">Abnormal leukocyte count</a></span><ul><li><span class="TLline"><a href="/medgen/663425" ref="tree=MeSH" title="MedGen record for Abnormal lymphocyte count">Abnormal lymphocyte count</a></span><ul><li><span class="matched_ds">Abnormal T cell count</span><ul><li><span class="TLline"><a href="/medgen/1371686" ref="tree=MeSH" title="MedGen record for Abnormal T cell subset distribution">Abnormal T cell subset distribution</a></span><ul><li><span class="TLline"><a href="/medgen/1702842" ref="tree=MeSH" title="MedGen record for Abnormal CD4+CD25+ regulatory T cell proportion">Abnormal CD4+CD25+ regulatory T cell proportion</a></span><ul><li><span class="TLline"><a href="/medgen/1688709" ref="tree=MeSH" title="MedGen record for Decreased proportion of CD4+CD25+ regulatory T cells">Decreased proportion of CD4+CD25+ regulatory T cells</a></span></li><li><span class="TLline"><a href="/medgen/1687349" ref="tree=MeSH" title="MedGen record for Increased proportion of CD4+CD25+ regulatory T cells">Increased proportion of CD4+CD25+ regulatory T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1619994" ref="tree=MeSH" title="MedGen record for Abnormal CD4:CD8 ratio">Abnormal CD4:CD8 ratio</a></span><ul><li><span class="TLline"><a href="/medgen/163125" ref="tree=MeSH" title="MedGen record for Decreased CD4:CD8 ratio">Decreased CD4:CD8 ratio</a></span></li><li><span class="TLline"><a href="/medgen/1614673" ref="tree=MeSH" title="MedGen record for Increased CD4:CD8 ratio">Increased CD4:CD8 ratio</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1720379" ref="tree=MeSH" title="MedGen record for Abnormal helper T cell proportion">Abnormal helper T cell proportion</a></span><ul><li><span class="TLline"><a href="/medgen/870281" ref="tree=MeSH" title="MedGen record for Decreased helper T cell proportion">Decreased helper T cell proportion</a></span></li><li><span class="TLline"><a href="/medgen/1708381" ref="tree=MeSH" title="MedGen record for Increased helper T cell proportion">Increased helper T cell proportion</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1619121" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD4-positive T cells">Abnormal proportion of CD4-positive T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1692348" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD4+ effector memory cells">Abnormal proportion of CD4+ effector memory cells</a></span></li><li><span class="TLline"><a href="/medgen/1712984" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD4-positive helper T cells">Abnormal proportion of CD4-positive helper T cells</a></span></li><li><span class="TLline"><a href="/medgen/1698933" ref="tree=MeSH" title="MedGen record for Decreased proportion of CD4-positive T cells">Decreased proportion of CD4-positive T cells</a></span></li><li><span class="TLline"><a href="/medgen/1704350" ref="tree=MeSH" title="MedGen record for Increased proportion of CD4-positive T cells">Increased proportion of CD4-positive T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1627283" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD8-positive T cells">Abnormal proportion of CD8-positive T cells</a></span><ul><li><span class="TLline"><a href="/medgen/374188" ref="tree=MeSH" title="MedGen record for Decreased proportion of CD8-positive T cells">Decreased proportion of CD8-positive T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1621823" ref="tree=MeSH" title="MedGen record for Abnormal proportion of double-negative alpha-beta regulatory T cell">Abnormal proportion of double-negative alpha-beta regulatory T cell</a></span><ul><li><span class="TLline"><a href="/medgen/395145" ref="tree=MeSH" title="MedGen record for Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells">Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells</a></span></li><li><span class="TLline"><a href="/medgen/1612852" ref="tree=MeSH" title="MedGen record for Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells">Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1759343" ref="tree=MeSH" title="MedGen record for Abnormal proportion of exhausted T cells">Abnormal proportion of exhausted T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1620482" ref="tree=MeSH" title="MedGen record for Increased proportion of exhausted T cells">Increased proportion of exhausted T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1718809" ref="tree=MeSH" title="MedGen record for Abnormal proportion of gamma-delta T cells">Abnormal proportion of gamma-delta T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1713360" ref="tree=MeSH" title="MedGen record for Decreased proportion of gamma-delta T cells">Decreased proportion of gamma-delta T cells</a></span></li><li><span class="TLline"><a href="/medgen/1712401" ref="tree=MeSH" title="MedGen record for Increased proportion of gamma-delta T cells">Increased proportion of gamma-delta T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1720035" ref="tree=MeSH" title="MedGen record for Abnormal proportion of immature gamma-delta T cells">Abnormal proportion of immature gamma-delta T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1709632" ref="tree=MeSH" title="MedGen record for Decreased proportion of immature gamma-delta T cells">Decreased proportion of immature gamma-delta T cells</a></span></li><li><span class="TLline"><a href="/medgen/1716763" ref="tree=MeSH" title="MedGen record for Increased proportion of immature gamma-delta T cells">Increased proportion of immature gamma-delta T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1686899" ref="tree=MeSH" title="MedGen record for Abnormal proportion of memory T cells">Abnormal proportion of memory T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1693154" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD4-positive, alpha-beta memory T cells">Abnormal proportion of CD4-positive, alpha-beta memory T cells</a></span></li><li><span class="TLline"><a href="/medgen/1702232" ref="tree=MeSH" title="MedGen record for Abnormal proportion of CD8-positive, alpha-beta memory T cells">Abnormal proportion of CD8-positive, alpha-beta memory T cells</a></span></li><li><span class="TLline"><a href="/medgen/1689962" ref="tree=MeSH" title="MedGen record for Decreased proportion of memory T cells">Decreased proportion of memory T cells</a></span></li><li><span class="TLline"><a href="/medgen/1695266" ref="tree=MeSH" title="MedGen record for Increased proportion of memory T cells">Increased proportion of memory T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1611359" ref="tree=MeSH" title="MedGen record for Abnormal proportion of naive T cells">Abnormal proportion of naive T cells</a></span><ul><li><span class="TLline"><a href="/medgen/1698894" ref="tree=MeSH" title="MedGen record for Abnormal proportion of naive CD4 T cells">Abnormal proportion of naive CD4 T cells</a></span></li><li><span class="TLline"><a href="/medgen/1696791" ref="tree=MeSH" title="MedGen record for Abnormal proportion of naive CD8 T cells">Abnormal proportion of naive CD8 T cells</a></span></li><li><span class="TLline"><a href="/medgen/1611928" ref="tree=MeSH" title="MedGen record for Decreased proportion of naive T cells">Decreased proportion of naive T cells</a></span></li><li><span class="TLline"><a href="/medgen/1618068" ref="tree=MeSH" title="MedGen record for Increased proportion of naive T cells">Increased proportion of naive T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1717265" ref="tree=MeSH" title="MedGen record for Clonal T cell receptor rearrangement">Clonal T cell receptor rearrangement</a></span></li><li><span class="TLline"><a href="/medgen/1369785" ref="tree=MeSH" title="MedGen record for Decreased proportion of CD3-positive T cells">Decreased proportion of CD3-positive T cells</a></span></li><li><span class="TLline"><a href="/medgen/1642955" ref="tree=MeSH" title="MedGen record for Increased proportion of HLA DR+ T cells">Increased proportion of HLA DR+ T cells</a></span></li><li><span class="TLline"><a href="/medgen/1782351" ref="tree=MeSH" title="MedGen record for Reduced proportion of mucosal-associated invariant T cells">Reduced proportion of mucosal-associated invariant T cells</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1611921" ref="tree=MeSH" title="MedGen record for Abnormally low T cell receptor excision circle level">Abnormally low T cell receptor excision circle level</a></span></li><li><span class="TLline"><a href="/medgen/419385" ref="tree=MeSH" title="MedGen record for T lymphocytopenia">T lymphocytopenia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_141630"><div><strong>X-linked agammaglobulinemia with growth hormone deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141630</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0472813</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">IGHD3 is characterized by agammaglobulinemia and markedly reduced numbers of B cells, short stature, delayed bone age, and good response to treatment with growth hormone (summary by Conley et al., 1991). For general phenotypic information and a discussion of genetic heterogeneity of IGHD, see 262400.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/141630">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_220906"><div><strong>X-linked severe combined immunodeficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220906</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1279481</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The phenotypic spectrum of X-linked severe combined immunodeficiency (X-SCID) ranges from typical X-SCID (early-onset disease in males that is fatal if not treated with hematopoietic stem cell transplantation [HSCT] or gene therapy) to atypical X-SCID (later-onset disease comprising phenotypes caused by variable immunodeficiency, immune dysregulation, and/or autoimmunity). Typical X-SCID. Prior to universal newborn screening (NBS) for SCID most males with typical X-SCID came to medical attention between ages three and six months because of recurrent infections, persistent infections, and infections with opportunistic organisms. With universal NBS for SCID, the common presentation for typical X-SCID is now an asymptomatic, healthy-appearing male infant. Atypical X-SCID, which usually is not detected by NBS, can manifest in the first years of life or later with one of the following: recurrent upper and lower respiratory tract infections with bronchiectasis; Omenn syndrome, a clinical phenotype caused by immune dysregulation; X-SCID combined immunodeficiency (often with recurrent infections, warts, and dermatitis); immune dysregulation and autoimmunity; or Epstein-Barr virus-related lymphoproliferative complications.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/220906">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_375137"><div><strong>Immunodeficiency 67</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375137</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1843256</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Immunodeficiency-67 (IMD67) is an autosomal recessive primary immunodeficiency characterized by recurrent severe systemic and invasive bacterial infections beginning in infancy or early childhood. The most common organisms implicated are Streptococcus pneumoniae and Staphylococcus aureus; Pseudomonas and atypical Mycobacteria may also be observed. IMD67 is life-threatening in infancy and early childhood. The first invasive infection typically occurs before 2 years of age, with meningitis representing up to 41% of the bacterial infections. The mortality rate in early childhood is high, with most deaths occurring before 8 years of age. Affected individuals have an impaired inflammatory response to infection, including lack of fever and neutropenia, although erythrocyte sedimentation rate (ESR) and C-reactive protein may be elevated. General immunologic workup tends to be normal, with normal levels of B cells, T cells, and NK cells. However, more detailed studies indicate impaired cytokine response to lipopolysaccharide (LPS) and IL1B (147720) stimulation; response to TNFA (191160) is usually normal. Patients have good antibody responses to most vaccinations, with the notable exception of pneumococcal vaccination. Viral, fungal, and parasitic infections are not generally observed. Early detection is critical in early childhood because prophylactic treatment with IVIg or certain antibiotics is effective; the disorder tends to improve naturally around adolescence. At the molecular level, the disorder results from impaired function of selective Toll receptor (see TLR4, 603030)/IL1R (see IL1R1, 147810) signaling pathways that ultimately activate NFKB (164011) to produce cytokines (summary by Ku et al., 2007; Picard et al., 2010; Grazioli et al., 2016). See also IMD68 (612260), caused by mutation in the MYD88 gene (602170), which shows a similar phenotype to IMD67. As the MYD88 and IRAK4 genes interact in the same intracellular signaling pathway, the clinical and cellular features are almost indistinguishable (summary by Picard et al., 2010).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/375137">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_460728"><div><strong>Immunodeficiency, common variable, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>460728</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3149378</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Common variable immunodeficiency (CVID) is a clinically and genetically heterogeneous group of disorders characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells are usually in the normal range, but can be low. Most individuals with CVID have onset of infections after age 10 years. CVID represents the most common form of primary immunodeficiency disorders and is the most common form of primary antibody deficiency. Approximately 10 to 20% of patients with a diagnosis of CVID have a family history of the disorder (reviews by Chapel et al., 2008, Conley et al., 2009, and Yong et al., 2009). Genetic Heterogeneity of Common Variable Immunodeficiency Common variable immunodeficiency is a genetically heterogeneous disorder. See also CVID2 (240500), caused by mutation in the TACI gene (TNFRSF13B; 604907); CVID3 (613493), caused by mutation in the CD19 gene (107265); CVID4 (613494), caused by mutation in the BAFFR gene (TNFRSF13C; 606269); CVID5 (613495), caused by mutation in the CD20 gene (112210); CVID6 (613496), caused by mutation in the CD81 gene (186845); CVID7 (614699), caused by mutation in the CD21 gene (CR2; 120650); CVID8 (614700), caused by mutation in the LRBA gene (606453); CVID10 (615577), caused by mutation in the NFKB2 gene (164012); CVID11 (615767), caused by mutation in the IL21 gene (605384); CVID12 (616576), caused by mutation in the NFKB1 gene (164011); CVID13 (616873), caused by mutation in the IKZF1 gene (603023); CVID14 (617765), caused by mutation in the IRF2BP2 gene (615332); and CVID15 (620670), caused by heterozygous mutation in the SEC61A1 gene (609213). The disorder formerly designated CVID9 has been found to be a form of autoimmune lymphoproliferative disorder; see ALPS3 (615559).</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/460728">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_461704"><div><strong>Immunodeficiency, common variable, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>461704</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150354</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/461704">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_462088"><div><strong>Immunodeficiency, common variable, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462088</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150738</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/462088">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_462089"><div><strong>Immunodeficiency, common variable, 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462089</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150739</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/462089">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_462090"><div><strong>Immunodeficiency, common variable, 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462090</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150740</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Any common variable immunodeficiency in which the cause of the disease is a mutation in the MS4A1 gene.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/462090">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_462091"><div><strong>Immunodeficiency, common variable, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462091</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3150741</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Any common variable immunodeficiency in which the cause of the disease is a mutation in the CD81 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462091">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1770239"><div><strong>X-linked lymphoproliferative disease due to SH2D1A deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1770239</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5399825</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">X-linked lymphoproliferative disease (XLP) in general is characterized by an inappropriate immune response to Epstein-Barr virus (EBV) infection leading to hemophagocytic lymphohistiocytosis (HLH) or severe mononucleosis, dysgammaglobulinemia, and lymphoproliferative disease (malignant lymphoma). The condition primarily affects males. XLP has two recognizable subtypes, XLP1 (due to pathogenic variants in SH2D1A) and XLP2 (due to pathogenic variants in XIAP). HLH / fulminant infectious mononucleosis is the most common presentation regardless of subtype. HLH is characterized as an acute illness with prolonged and high fever, bi- or trilineage cytopenias, and hepatosplenomegaly, which is often severe or fatal. Death is generally secondary to liver failure or multisystem organ dysfunction. In those with XLP1, dys- or hypogammaglobulinemia can lead to varying degrees of humoral immune dysfunction associated with bronchiectasis and recurrent respiratory infections that, if untreated, may result in death. Lymphoproliferative disease (malignant lymphoma) and other lymphoproliferative diseases are specific to XLP1 and often develop in childhood, usually following EBV exposure. Rarer findings in those with XLP1 can include aplastic anemia, vasculitis, and lymphoid granulomatosis. Males with XLP2 are more likely to have HLH without EBV infection, recurrent episodes of HLH (which is not typically seen in those with XLP1), splenomegaly, and gastrointestinal disease, including enterocolitis and perirectal abscesses or fistulae. Rarely, individuals with XLP2 and inflammatory bowel disease have been reported to develop inflammatory liver disease, which can progress to fatal liver failure. Transient hypogammaglobulinemia has been rarely observed in those with XLP2. To date, neither lymphoproliferative disease nor common variable immunodeficiency has been reported in males with XLP2. Heterozygous females rarely have symptoms. There are, however, increasing numbers of reports of affected females with unfavorable (skewed) X-chromosome inactivation favoring the X chromosome with the pathogenic variant who develop HLH, inflammatory bowel disease, and erythema nodosum.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1770239">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1799211"><div><strong>IL21-related infantile inflammatory bowel disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1799211</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5567788</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">A rare autosomal recessive primary immunodeficiency characterized by infancy onset of severe inflammatory bowel disease with life-threatening diarrhea and failure to thrive, oral aphthous ulcers, and recurrent severe upper and lower respiratory tract infections with finger clubbing. Laboratory examination reveals increased IgE and decreased IgG levels, as well as reduced numbers of circulating CD19+ B-cells including IgM+ naive and class-switched IgG memory B-cells, with a concomitant increase in transitional B-cells, while T-cell numbers and function are normal.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1799211">Condition Record</a></div></div>
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||
<div class="divPopper rprt" id="rdis_1841236"><div><strong>Autoimmune disease, multisystem, infantile-onset, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841236</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830600</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Infantile-onset multisystem autoimmune disease-3 (ADMIO3) is an autosomal recessive disorder of immune dysregulation characterized by the onset of various systemic autoimmune manifestations in the first months or years of life. Features may include hypothyroidism, type 1 diabetes mellitus, systemic inflammatory manifestations (fever, hepatomegaly), and autoimmune cytopenias. Laboratory studies show normal levels of T, B, and NK cells, but CD4+ (see 186940) T cells demonstrate hyperproliferation when stimulated in vitro (Janssen et al., 2022). For a discussion of genetic heterogeneity of ADMIO, see ADMIO1 (615952).</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841236">Condition Record</a></div></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841236" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autoimmune disease, multisystem, infantile-onset, 3</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1799211" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">IL21-related infantile inflammatory bowel disease</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375137" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 67</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_460728" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 1</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_461704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 2</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (12)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462088" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 3</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462089" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 4</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462090" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 5</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462091" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency, common variable, 6</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_141630" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked agammaglobulinemia with growth hormone deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1770239" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked lymphoproliferative disease due to SH2D1A deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_220906" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked severe combined immunodeficiency</a></div></span></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35737255">Protein-losing Enteropathy as a Complication and/or Differential Diagnosis of Common Variable Immunodeficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sanges S,
|
||
Germain N,
|
||
Vignes S,
|
||
Séguy D,
|
||
Stabler S,
|
||
Etienne N,
|
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Terriou L,
|
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Launay D,
|
||
Hachulla É,
|
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Huglo D,
|
||
Dubucquoi S,
|
||
Labalette M,
|
||
Lefèvre G</span><br />
|
||
<span class="medgenPMjournal">J Clin Immunol</span>
|
||
2022 Oct;42(7):1461-1472.
|
||
Epub 2022 Jun 23
|
||
doi: 10.1007/s10875-022-01299-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35737255" target="_blank">35737255</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27967252">Hyperleukocytosis and leukostasis: management of a medical emergency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giammarco S,
|
||
Chiusolo P,
|
||
Piccirillo N,
|
||
Di Giovanni A,
|
||
Metafuni E,
|
||
Laurenti L,
|
||
Sica S,
|
||
Pagano L</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2017 Feb;10(2):147-154.
|
||
Epub 2016 Dec 26
|
||
doi: 10.1080/17474086.2017.1270754.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27967252" target="_blank">27967252</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25502893">Update on biology and treatment of T-cell acute lymphoblastic leukaemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patrick K,
|
||
Vora A</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Pediatr</span>
|
||
2015 Feb;27(1):44-9.
|
||
doi: 10.1097/MOP.0000000000000171.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25502893" target="_blank">25502893</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(abnormal%20t%20cell%20count)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (73)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35784324">B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fekrvand S,
|
||
Khanmohammadi S,
|
||
Abolhassani H,
|
||
Yazdani R</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2022;13:912826.
|
||
Epub 2022 Jun 15
|
||
doi: 10.3389/fimmu.2022.912826.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35784324" target="_blank">35784324</a><a href="/pmc/articles/PMC9241517" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23454892">Signature MicroRNA expression patterns identified in humans with 22q11.2 deletion/DiGeorge syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de la Morena MT,
|
||
Eitson JL,
|
||
Dozmorov IM,
|
||
Belkaya S,
|
||
Hoover AR,
|
||
Anguiano E,
|
||
Pascual MV,
|
||
van Oers NSC</span><br />
|
||
<span class="medgenPMjournal">Clin Immunol</span>
|
||
2013 Apr;147(1):11-22.
|
||
Epub 2013 Jan 30
|
||
doi: 10.1016/j.clim.2013.01.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23454892" target="_blank">23454892</a><a href="/pmc/articles/PMC3748608" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20354268">The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Appay V,
|
||
Sauce D,
|
||
Prelog M</span><br />
|
||
<span class="medgenPMjournal">Aging (Albany NY)</span>
|
||
2010 Mar 20;2(2):78-81.
|
||
doi: 10.18632/aging.100122.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20354268" target="_blank">20354268</a><a href="/pmc/articles/PMC2850143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17285884">Transient myeloproliferative disorder associated with trisomy 21.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kruger B</span><br />
|
||
<span class="medgenPMjournal">Neonatal Netw</span>
|
||
2007 Jan-Feb;26(1):7-19.
|
||
doi: 10.1891/0730-0832.26.1.7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17285884" target="_blank">17285884</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3258373">Lymphocytic gastritis--relationship to Campylobacter pylori infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dixon MF,
|
||
Wyatt JI,
|
||
Burke DA,
|
||
Rathbone BJ</span><br />
|
||
<span class="medgenPMjournal">J Pathol</span>
|
||
1988 Feb;154(2):125-32.
|
||
doi: 10.1002/path.1711540204.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3258373" target="_blank">3258373</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (992)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38129713">Evaluation of Clinical and Immunological Alterations Associated with ICF Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bilgic Eltan S,
|
||
Nain E,
|
||
Catak MC,
|
||
Ezen E,
|
||
Sefer AP,
|
||
Karimi N,
|
||
Kiykim A,
|
||
Kolukisa B,
|
||
Baser D,
|
||
Bulutoglu A,
|
||
Kasap N,
|
||
Yorgun Altunbas M,
|
||
Yalcin Gungoren E,
|
||
Kendir Demirkol Y,
|
||
Kutlug S,
|
||
Hancioglu G,
|
||
Dilek F,
|
||
Yildiran A,
|
||
Ozen A,
|
||
Karakoc-Aydiner E,
|
||
Erman B,
|
||
Baris S</span><br />
|
||
<span class="medgenPMjournal">J Clin Immunol</span>
|
||
2023 Dec 22;44(1):26.
|
||
doi: 10.1007/s10875-023-01620-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38129713" target="_blank">38129713</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33900694">Immunological Biomarkers of COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lei R,
|
||
Mohan C</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Immunol</span>
|
||
2020;40(6):497-512.
|
||
doi: 10.1615/CritRevImmunol.2020035652.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33900694" target="_blank">33900694</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29159871">Immunodeficiency in CHARGE syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mehr S,
|
||
Hsu P,
|
||
Campbell D</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet C Semin Med Genet</span>
|
||
2017 Dec;175(4):516-523.
|
||
Epub 2017 Nov 21
|
||
doi: 10.1002/ajmg.c.31594.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29159871" target="_blank">29159871</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21485997">Evaluation of the child with immunodeficiency disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woo CK,
|
||
Bahna SL</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
2011 Apr;40(4):205-11.
|
||
doi: 10.3928/00904481-20110316-08.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21485997" target="_blank">21485997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17285884">Transient myeloproliferative disorder associated with trisomy 21.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kruger B</span><br />
|
||
<span class="medgenPMjournal">Neonatal Netw</span>
|
||
2007 Jan-Feb;26(1):7-19.
|
||
doi: 10.1891/0730-0832.26.1.7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17285884" target="_blank">17285884</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (596)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36536403">A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang H,
|
||
Tsao ST,
|
||
Gu M,
|
||
Fu C,
|
||
He F,
|
||
Li X,
|
||
Zhang M,
|
||
Li N,
|
||
Hu HM</span><br />
|
||
<span class="medgenPMjournal">J Transl Med</span>
|
||
2022 Dec 19;20(1):608.
|
||
doi: 10.1186/s12967-022-03833-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36536403" target="_blank">36536403</a><a href="/pmc/articles/PMC9764707" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21485997">Evaluation of the child with immunodeficiency disorder.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woo CK,
|
||
Bahna SL</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
2011 Apr;40(4):205-11.
|
||
doi: 10.3928/00904481-20110316-08.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21485997" target="_blank">21485997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20687509">Dyskeratosis congenita.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gupta V,
|
||
Kumar A</span><br />
|
||
<span class="medgenPMjournal">Adv Exp Med Biol</span>
|
||
2010;685:215-9.
|
||
doi: 10.1007/978-1-4419-6448-9_20.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20687509" target="_blank">20687509</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20236866">Thymus transplantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Markert ML,
|
||
Devlin BH,
|
||
McCarthy EA</span><br />
|
||
<span class="medgenPMjournal">Clin Immunol</span>
|
||
2010 May;135(2):236-46.
|
||
Epub 2010 Mar 16
|
||
doi: 10.1016/j.clim.2010.02.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20236866" target="_blank">20236866</a><a href="/pmc/articles/PMC3646264" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18217129">Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stasi R,
|
||
Evangelista ML,
|
||
Stipa E,
|
||
Buccisano F,
|
||
Venditti A,
|
||
Amadori S</span><br />
|
||
<span class="medgenPMjournal">Thromb Haemost</span>
|
||
2008 Jan;99(1):4-13.
|
||
doi: 10.1160/TH07-08-0513.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18217129" target="_blank">18217129</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (554)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37735552">The role of T cells and myeloid-derived suppressor cells in refractory immune thrombocytopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yazdanbakhsh K,
|
||
Provan D,
|
||
Semple JW</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
2023 Oct;203(1):54-61.
|
||
doi: 10.1111/bjh.19079.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37735552" target="_blank">37735552</a><a href="/pmc/articles/PMC11493757" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28665419">Acute lymphoblastic leukemia: a comprehensive review and 2017 update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Terwilliger T,
|
||
Abdul-Hay M</span><br />
|
||
<span class="medgenPMjournal">Blood Cancer J</span>
|
||
2017 Jun 30;7(6):e577.
|
||
doi: 10.1038/bcj.2017.53.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28665419" target="_blank">28665419</a><a href="/pmc/articles/PMC5520400" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27967252">Hyperleukocytosis and leukostasis: management of a medical emergency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giammarco S,
|
||
Chiusolo P,
|
||
Piccirillo N,
|
||
Di Giovanni A,
|
||
Metafuni E,
|
||
Laurenti L,
|
||
Sica S,
|
||
Pagano L</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2017 Feb;10(2):147-154.
|
||
Epub 2016 Dec 26
|
||
doi: 10.1080/17474086.2017.1270754.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27967252" target="_blank">27967252</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20354268">The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Appay V,
|
||
Sauce D,
|
||
Prelog M</span><br />
|
||
<span class="medgenPMjournal">Aging (Albany NY)</span>
|
||
2010 Mar 20;2(2):78-81.
|
||
doi: 10.18632/aging.100122.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20354268" target="_blank">20354268</a><a href="/pmc/articles/PMC2850143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1971717">Asymptomatic patients with HIV infection. Keeping them well.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sarti GM</span><br />
|
||
<span class="medgenPMjournal">Postgrad Med</span>
|
||
1990 Jun;87(8):143-54.
|
||
doi: 10.1080/00325481.1990.11704679.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1971717" target="_blank">1971717</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (495)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38129713">Evaluation of Clinical and Immunological Alterations Associated with ICF Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bilgic Eltan S,
|
||
Nain E,
|
||
Catak MC,
|
||
Ezen E,
|
||
Sefer AP,
|
||
Karimi N,
|
||
Kiykim A,
|
||
Kolukisa B,
|
||
Baser D,
|
||
Bulutoglu A,
|
||
Kasap N,
|
||
Yorgun Altunbas M,
|
||
Yalcin Gungoren E,
|
||
Kendir Demirkol Y,
|
||
Kutlug S,
|
||
Hancioglu G,
|
||
Dilek F,
|
||
Yildiran A,
|
||
Ozen A,
|
||
Karakoc-Aydiner E,
|
||
Erman B,
|
||
Baris S</span><br />
|
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<span class="medgenPMjournal">J Clin Immunol</span>
|
||
2023 Dec 22;44(1):26.
|
||
doi: 10.1007/s10875-023-01620-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38129713" target="_blank">38129713</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37735552">The role of T cells and myeloid-derived suppressor cells in refractory immune thrombocytopenia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yazdanbakhsh K,
|
||
Provan D,
|
||
Semple JW</span><br />
|
||
<span class="medgenPMjournal">Br J Haematol</span>
|
||
2023 Oct;203(1):54-61.
|
||
doi: 10.1111/bjh.19079.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37735552" target="_blank">37735552</a><a href="/pmc/articles/PMC11493757" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35732344">Phenotypical changes and clinical significance of CD4(+)/CD8(+) T cells in SLE.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yuan S,
|
||
Zeng Y,
|
||
Li J,
|
||
Wang C,
|
||
Li W,
|
||
He Z,
|
||
Ye J,
|
||
Li F,
|
||
Chen Y,
|
||
Lin X,
|
||
Yu N,
|
||
Cai X</span><br />
|
||
<span class="medgenPMjournal">Lupus Sci Med</span>
|
||
2022 Jun;9(1)
|
||
doi: 10.1136/lupus-2022-000660.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35732344" target="_blank">35732344</a><a href="/pmc/articles/PMC9226979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33052516">Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moeini Shad T,
|
||
Yousefi B,
|
||
Amirifar P,
|
||
Delavari S,
|
||
Rae W,
|
||
Kokhaei P,
|
||
Abolhassani H,
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||
Aghamohammadi A,
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Yazdani R</span><br />
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<span class="medgenPMjournal">J Clin Immunol</span>
|
||
2021 Jan;41(1):76-88.
|
||
Epub 2020 Oct 14
|
||
doi: 10.1007/s10875-020-00881-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33052516" target="_blank">33052516</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1857267">HIV-1 infection and hematologic picture.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Re MC,
|
||
Zauli G,
|
||
Furlini G,
|
||
Giovannini M,
|
||
La Placa M</span><br />
|
||
<span class="medgenPMjournal">Microbiologica</span>
|
||
1991 Apr;14(2):165-76.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1857267" target="_blank">1857267</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (738)</a></div></div>
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<div class="nl"><a target="_blank" href="/pubmed/37093609">Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis Without Therapeutic Immune Suppression.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McEntire CRS,
|
||
Fletcher A,
|
||
Toledano M,
|
||
Epstein S,
|
||
White E,
|
||
Tan CS,
|
||
Mao-Draayer Y,
|
||
Banks SA,
|
||
Aksamit AJ,
|
||
Gelfand JM,
|
||
Thakur KT,
|
||
Anand P,
|
||
Cortese I,
|
||
Bhattacharyya S</span><br />
|
||
<span class="medgenPMjournal">JAMA Neurol</span>
|
||
2023 Jun 1;80(6):624-633.
|
||
doi: 10.1001/jamaneurol.2023.0841.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37093609" target="_blank">37093609</a><a href="/pmc/articles/PMC10126944" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35040086">Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qin R,
|
||
He L,
|
||
Yang Z,
|
||
Jia N,
|
||
Chen R,
|
||
Xie J,
|
||
Fu W,
|
||
Chen H,
|
||
Lin X,
|
||
Huang R,
|
||
Luo T,
|
||
Liu Y,
|
||
Yao S,
|
||
Jiang M,
|
||
Li J</span><br />
|
||
<span class="medgenPMjournal">Clin Rev Allergy Immunol</span>
|
||
2023 Feb;64(1):33-65.
|
||
Epub 2022 Jan 18
|
||
doi: 10.1007/s12016-021-08908-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35040086" target="_blank">35040086</a><a href="/pmc/articles/PMC8763427" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36430805">Activation of the Monocyte/Macrophage System and Abnormal Blood Levels of Lymphocyte Subpopulations in Individuals with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arteaga-Henríquez G,
|
||
Lugo-Marín J,
|
||
Gisbert L,
|
||
Setién-Ramos I,
|
||
Martínez-Gallo M,
|
||
Pujol-Borrell R,
|
||
Ramos-Quiroga JA</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2022 Nov 18;23(22)
|
||
doi: 10.3390/ijms232214329.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36430805" target="_blank">36430805</a><a href="/pmc/articles/PMC9699353" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31570667">Abnormal QTc syndrome in HIV-infected patients: a systematic review of prevalence and risk factors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chastain DB,
|
||
Veve MP,
|
||
Wagner JL</span><br />
|
||
<span class="medgenPMjournal">Antivir Ther</span>
|
||
2019;24(6):459-465.
|
||
doi: 10.3851/IMP3335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31570667" target="_blank">31570667</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30833946">The Regulatory T Cell in Active Systemic Lupus Erythematosus Patients: A Systemic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li W,
|
||
Deng C,
|
||
Yang H,
|
||
Wang G</span><br />
|
||
<span class="medgenPMjournal">Front Immunol</span>
|
||
2019;10:159.
|
||
Epub 2019 Feb 18
|
||
doi: 10.3389/fimmu.2019.00159.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30833946" target="_blank">30833946</a><a href="/pmc/articles/PMC6387904" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20T%20cell%20count%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(abnormal%20t%20cell%20count)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Abnormal%20T%20cell%20count%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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