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<meta name="keywords" content="C3887964, apkd3, autosomal dominant polycystic kidney disease caused by mutation in ganab, disease or syndrome, ganab, ganab autosomal dominant polycystic kidney disease, pkd3, polycystic kidney disease 3, polycystic kidney disease 3 with or without polycystic liver disease, polycystic kidney disease 3, autosomal dominant, polycystic kidney disease type 3, polycystic kidney disease, adult, type 3, polycystic kidney disease, adult, type iii, polycystic kidney disease, type 3, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset multisystem disorder characterized by bilateral kidney cysts, liver cysts, and an increased risk of intracranial aneurysms. Other manifestations include: cysts in the pancreas, seminal vesicles, and arachnoid membrane; dilatation of the aortic root and dissection of the thoracic aorta; mitral valve prolapse; and abdominal wall hernias. Kidney manifestations include early-onset hypertension, kidney pain, and kidney insufficiency. Approximately 50% of individuals with ADPKD have end-stage kidney disease (ESKD) by age 60 years. The prevalence of liver cysts increases with age and occasionally results in clinically significant severe polycystic liver disease (PLD), most often in females. Overall, the prevalence of intracranial aneurysms is fivefold higher than in the general population and further increased in those with a positive family history of aneurysms or subarachnoid hemorrhage. There is substantial variability in the severity of kidney disease and other extra-kidney manifestations." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=854672
|
||
ConceptID=C3887964
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Polycystic kidney disease 3 with or without polycystic liver disease<span class="h1sub">(APKD3; PKD3)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854672</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3887964</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Polycystic kidney disease 3; POLYCYSTIC KIDNEY DISEASE, ADULT, TYPE III</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="GANAB - ID: 23193 - NCBI Gene" href="/gene/23193" class="medgenPMinfo">GANAB</a> (11q12.3)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0010916" target="_blank">MONDO:0010916</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/600666" target="_blank">600666</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1246" target="_blank">Polycystic Kidney Disease, Autosomal Dominant</a></div><div>Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset multisystem disorder characterized by bilateral kidney cysts, liver cysts, and an increased risk of intracranial aneurysms. Other manifestations include: cysts in the pancreas, seminal vesicles, and arachnoid membrane; dilatation of the aortic root and dissection of the thoracic aorta; mitral valve prolapse; and abdominal wall hernias. Kidney manifestations include early-onset hypertension, kidney pain, and kidney insufficiency. Approximately 50% of individuals with ADPKD have end-stage kidney disease (ESKD) by age 60 years. The prevalence of liver cysts increases with age and occasionally results in clinically significant severe polycystic liver disease (PLD), most often in females. Overall, the prevalence of intracranial aneurysms is fivefold higher than in the general population and further increased in those with a positive family history of aneurysms or subarachnoid hemorrhage. There is substantial variability in the severity of kidney disease and other extra-kidney manifestations. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Summary" target="NBK1246">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Diagnosis" target="NBK1246">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Clinical_Characteristics" target="NBK1246">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Genetically_Related_Allelic_Disor" target="NBK1246">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Differential_Diagnosis" target="NBK1246">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Management" target="NBK1246">Management</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Genetic_Counseling" target="NBK1246">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Resources" target="NBK1246">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Molecular_Genetics" target="NBK1246">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.Chapter_Notes" target="NBK1246">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1246#pkd-ad.References" target="NBK1246">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Peter C Harris | Vicente E Torres <a href="/books/NBK1246" target="NBK1246" title="NCBI Bookshelf: Polycystic Kidney Disease, Autosomal Dominant">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Polycystic kidney disease-3, a form of autosomal dominant PKD (ADPKD), is characterized by renal cysts, often associated with liver cysts, that may lead to organ dysfunction. Affected individuals usually present in mid to late adulthood with progressive cysts in the kidney and/or liver. The renal disease is relatively mild, and only some patients develop hypertension; renal insufficiency usually does not occur. The liver disease shows a wide spectrum of severity: some patients have no cysts, whereas others have severe liver involvement (summary by Porath et al., 2016).
|
||
For a discussion of genetic heterogeneity of PKD, see PKD1 (173900). <a target="_blank" href="http://www.omim.org/entry/600666">http://www.omim.org/entry/600666</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Polycystic kidney disease is a disorder that affects the kidneys and other organs. Clusters of fluid-filled sacs, called cysts, develop in the kidneys and interfere with their ability to filter waste products from the blood. The growth of cysts causes the kidneys to become enlarged and can lead to kidney failure. Cysts may also develop in other organs, particularly the liver.<br /><br />Frequent complications of polycystic kidney disease include dangerously high blood pressure (hypertension), pain in the back or sides, blood in the urine (hematuria), recurrent urinary tract infections, kidney stones, and heart valve abnormalities. Additionally, people with polycystic kidney disease have an increased risk of an abnormal bulging (an aneurysm) in a large blood vessel called the aorta or in blood vessels at the base of the brain. Aneurysms can be life-threatening if they tear or rupture.<br /><br />The two major forms of polycystic kidney disease are distinguished by the usual age of onset and the pattern in which it is passed through families. The autosomal dominant form (sometimes called ADPKD) has signs and symptoms that typically begin in adulthood, although cysts in the kidney are often present from birth or childhood. Autosomal dominant polycystic kidney disease can be further divided into type 1 and type 2, depending on the genetic cause. The autosomal recessive form of polycystic kidney disease (sometimes called ARPKD) is much rarer and is often lethal early in life. The signs and symptoms of this condition are usually apparent at birth or in early infancy. <a target="_blank" href="https://medlineplus.gov/genetics/condition/polycystic-kidney-disease">https://medlineplus.gov/genetics/condition/polycystic-kidney-disease</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_9639"><div><strong>Polycystic kidney disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9639</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022680</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of multiple cysts in both kidneys.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9639">Feature record</a> | <a href="/medgen?term=%22Polycystic%20kidney%20disease%22%5BClinical%20Features%5D%20OR%209639%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_6969"><div><strong>Hypertensive disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6969</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0020538</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of chronic increased pressure in the systemic arterial system.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6969">Feature record</a> | <a href="/medgen?term=%22Hypertensive%20disorder%22%5BClinical%20Features%5D%20OR%206969%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1386760"><div><strong>Dilatation of the cerebral artery</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1386760</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4476540</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a localized dilatation or ballooning of a cerebral artery.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1386760">Feature record</a> | <a href="/medgen?term=%22Dilatation%20of%20the%20cerebral%20artery%22%5BClinical%20Features%5D%20OR%201386760%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_65430"><div><strong>Decreased liver function</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65430</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0232744</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Reduced ability of the liver to perform its functions.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/65430">Feature record</a> | <a href="/medgen?term=%22Decreased%20liver%20function%22%5BClinical%20Features%5D%20OR%2065430%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_82761"><div><strong>Hepatic cysts</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82761</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0267834</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A cystic lesion located in the liver.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82761">Feature record</a> | <a href="/medgen?term=%22Hepatic%20cysts%22%5BClinical%20Features%5D%20OR%2082761%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1386760" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilatation of the cerebral artery</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6969" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertensive disorder</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_65430" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased liver function</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82761" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hepatic cysts</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9639" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polycystic kidney disease</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0085413[DISCUI]&test_type=Clinical" ref="ncbi_uid=88404">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0085413[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=88404">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=88404" target="_blank" href="/omim/173900">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1246/" ref="ncbi_uid=88404">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=88404" ref="ncbi_uid=88404">V</a></span></span><span class="TLline"><a href="/medgen/88404" ref="tree=GTR&ncbi_uid=88404&link_uid=88404" title="View MedGen record for 'Autosomal dominant polycystic kidney disease'">Autosomal dominant polycystic kidney disease</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751306[DISCUI]&test_type=Clinical" ref="ncbi_uid=442699">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=442699" target="_blank" href="/omim/173910">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1246/" ref="ncbi_uid=442699">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=442699" ref="ncbi_uid=442699">V</a></span></span><span class="TLline"><a href="/medgen/442699" ref="tree=GTR&ncbi_uid=442699&link_uid=442699" title="View MedGen record for 'Polycystic kidney disease 2'">Polycystic kidney disease 2</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3887964[DISCUI]&test_type=Clinical" ref="ncbi_uid=854672">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=854672" target="_blank" href="/omim/104160">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1246/" ref="ncbi_uid=854672">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=854672" ref="ncbi_uid=854672">V</a></span></span><span class="TLline">Polycystic kidney disease 3 with or without polycystic liver disease</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3149841[DISCUI]&test_type=Clinical" ref="ncbi_uid=461191">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=461191" target="_blank" href="/omim/173900">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1246/" ref="ncbi_uid=461191">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=461191" ref="ncbi_uid=461191">V</a></span></span><span class="TLline"><a href="/medgen/461191" ref="tree=GTR&ncbi_uid=461191&link_uid=461191" title="View MedGen record for 'Polycystic kidney disease, adult type'">Polycystic kidney disease, adult type</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/1842297" ref="tree=MeSH" title="MedGen record for Familial cystic renal disease">Familial cystic renal disease</a></span><ul><li><span class="TLline"><a href="/medgen/88404" ref="tree=MeSH" title="MedGen record for Autosomal dominant polycystic kidney disease">Autosomal dominant polycystic kidney disease</a></span><ul><li><span class="matched_ds">Polycystic kidney disease 3 with or without polycystic liver disease</span></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38958301">ACG Clinical Guideline: Focal Liver Lesions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frenette C,
|
||
Mendiratta-Lala M,
|
||
Salgia R,
|
||
Wong RJ,
|
||
Sauer BG,
|
||
Pillai A</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2024 Jul 1;119(7):1235-1271.
|
||
Epub 2024 Jan 26
|
||
doi: 10.14309/ajg.0000000000002857.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38958301" target="_blank">38958301</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34980890">Patient-centred approaches for the management of unpleasant symptoms in kidney disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kalantar-Zadeh K,
|
||
Lockwood MB,
|
||
Rhee CM,
|
||
Tantisattamo E,
|
||
Andreoli S,
|
||
Balducci A,
|
||
Laffin P,
|
||
Harris T,
|
||
Knight R,
|
||
Kumaraswami L,
|
||
Liakopoulos V,
|
||
Lui SF,
|
||
Kumar S,
|
||
Ng M,
|
||
Saadi G,
|
||
Ulasi I,
|
||
Tong A,
|
||
Li PK</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Nephrol</span>
|
||
2022 Mar;18(3):185-198.
|
||
Epub 2022 Jan 3
|
||
doi: 10.1038/s41581-021-00518-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34980890" target="_blank">34980890</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34034501">A review of the diagnosis and management of liver hydatid cyst.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferrer Inaebnit E,
|
||
Molina Romero FX,
|
||
Segura Sampedro JJ,
|
||
González Argenté X,
|
||
Morón Canis JM</span><br />
|
||
<span class="medgenPMjournal">Rev Esp Enferm Dig</span>
|
||
2022 Jan;114(1):35-41.
|
||
doi: 10.17235/reed.2021.7896/2021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34034501" target="_blank">34034501</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (195)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35134221">An update on the use of tolvaptan for autosomal dominant polycystic kidney disease: consensus statement on behalf of the ERA Working Group on Inherited Kidney Disorders, the European Rare Kidney Disease Reference Network and Polycystic Kidney Disease International.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Müller RU,
|
||
Messchendorp AL,
|
||
Birn H,
|
||
Capasso G,
|
||
Cornec-Le Gall E,
|
||
Devuyst O,
|
||
van Eerde A,
|
||
Guirchoun P,
|
||
Harris T,
|
||
Hoorn EJ,
|
||
Knoers NVAM,
|
||
Korst U,
|
||
Mekahli D,
|
||
Le Meur Y,
|
||
Nijenhuis T,
|
||
Ong ACM,
|
||
Sayer JA,
|
||
Schaefer F,
|
||
Servais A,
|
||
Tesar V,
|
||
Torra R,
|
||
Walsh SB,
|
||
Gansevoort RT</span><br />
|
||
<span class="medgenPMjournal">Nephrol Dial Transplant</span>
|
||
2022 Apr 25;37(5):825-839.
|
||
doi: 10.1093/ndt/gfab312.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35134221" target="_blank">35134221</a><a href="/pmc/articles/PMC9035348" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33940108">Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Burgmaier K,
|
||
Brinker L,
|
||
Erger F,
|
||
Beck BB,
|
||
Benz MR,
|
||
Bergmann C,
|
||
Boyer O,
|
||
Collard L,
|
||
Dafinger C,
|
||
Fila M,
|
||
Kowalewska C,
|
||
Lange-Sperandio B,
|
||
Massella L,
|
||
Mastrangelo A,
|
||
Mekahli D,
|
||
Miklaszewska M,
|
||
Ortiz-Bruechle N,
|
||
Patzer L,
|
||
Prikhodina L,
|
||
Ranchin B,
|
||
Ranguelov N,
|
||
Schild R,
|
||
Seeman T,
|
||
Sever L,
|
||
Sikora P,
|
||
Szczepanska M,
|
||
Teixeira A,
|
||
Thumfart J,
|
||
Uetz B,
|
||
Weber LT,
|
||
Wühl E,
|
||
Zerres K;
|
||
ESCAPE Study group;
|
||
GPN study group,
|
||
Dötsch J,
|
||
Schaefer F,
|
||
Liebau MC;
|
||
ARegPKD consortium</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2021 Sep;100(3):650-659.
|
||
Epub 2021 Apr 30
|
||
doi: 10.1016/j.kint.2021.04.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33940108" target="_blank">33940108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33039432">Ciliopathies and the Kidney: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McConnachie DJ,
|
||
Stow JL,
|
||
Mallett AJ</span><br />
|
||
<span class="medgenPMjournal">Am J Kidney Dis</span>
|
||
2021 Mar;77(3):410-419.
|
||
Epub 2020 Oct 9
|
||
doi: 10.1053/j.ajkd.2020.08.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33039432" target="_blank">33039432</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30819518">Autosomal dominant polycystic kidney disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cornec-Le Gall E,
|
||
Alam A,
|
||
Perrone RD</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2019 Mar 2;393(10174):919-935.
|
||
Epub 2019 Feb 25
|
||
doi: 10.1016/S0140-6736(18)32782-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30819518" target="_blank">30819518</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8114857">The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Klahr S,
|
||
Levey AS,
|
||
Beck GJ,
|
||
Caggiula AW,
|
||
Hunsicker L,
|
||
Kusek JW,
|
||
Striker G</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
1994 Mar 31;330(13):877-84.
|
||
doi: 10.1056/NEJM199403313301301.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8114857" target="_blank">8114857</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1595)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33940108">Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Burgmaier K,
|
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Brinker L,
|
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Erger F,
|
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Beck BB,
|
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Benz MR,
|
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Bergmann C,
|
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Boyer O,
|
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Collard L,
|
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Dafinger C,
|
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Fila M,
|
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Kowalewska C,
|
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Lange-Sperandio B,
|
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Massella L,
|
||
Mastrangelo A,
|
||
Mekahli D,
|
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Miklaszewska M,
|
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Ortiz-Bruechle N,
|
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Patzer L,
|
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Prikhodina L,
|
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Ranchin B,
|
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Ranguelov N,
|
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Schild R,
|
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Seeman T,
|
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Sever L,
|
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Sikora P,
|
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Szczepanska M,
|
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Teixeira A,
|
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Thumfart J,
|
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Uetz B,
|
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Weber LT,
|
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Wühl E,
|
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Zerres K;
|
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ESCAPE Study group;
|
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GPN study group,
|
||
Dötsch J,
|
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Schaefer F,
|
||
Liebau MC;
|
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ARegPKD consortium</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2021 Sep;100(3):650-659.
|
||
Epub 2021 Apr 30
|
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doi: 10.1016/j.kint.2021.04.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33940108" target="_blank">33940108</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/32690722">Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Lanktree MB,
|
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Haghighi A,
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di Bari I,
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Song X,
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Pei Y</span><br />
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<span class="medgenPMjournal">Clin J Am Soc Nephrol</span>
|
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2021 May 8;16(5):790-799.
|
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Epub 2020 Jul 20
|
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doi: 10.2215/CJN.02320220.
|
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<span class="bold">PMID: </span><a href="/pubmed/32690722" target="_blank">32690722</a><a href="/pmc/articles/PMC8259493" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/30819518">Autosomal dominant polycystic kidney disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cornec-Le Gall E,
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Alam A,
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Perrone RD</span><br />
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2019 Mar 2;393(10174):919-935.
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Epub 2019 Feb 25
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doi: 10.1016/S0140-6736(18)32782-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30819518" target="_blank">30819518</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/28640449">Polycystic Kidney Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ghata J,
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<span class="medgenPMjournal">Compr Physiol</span>
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2017 Jun 18;7(3):945-975.
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<span class="bold">PMID: </span><a href="/pubmed/28640449" target="_blank">28640449</a></div>
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|
||
<div class="nl"><a target="_blank" href="/pubmed/3041293">Adult dominant polycystic kidney disease--clinical problems.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zeier M,
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Geberth S,
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Ritz E,
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Jaeger T,
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Waldherr R</span><br />
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<span class="medgenPMjournal">Nephron</span>
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<span class="bold">PMID: </span><a href="/pubmed/3041293" target="_blank">3041293</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1477)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35328738">Autosomal Dominant Polycystic Kidney Disease: From Pathophysiology of Cystogenesis to Advances in the Treatment.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30819518">Autosomal dominant polycystic kidney disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cornec-Le Gall E,
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Alam A,
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2019 Mar 2;393(10174):919-935.
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<span class="bold">PMID: </span><a href="/pubmed/30819518" target="_blank">30819518</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29105594">Tolvaptan in Later-Stage Autosomal Dominant Polycystic Kidney Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Torres VE,
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Chapman AB,
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Devuyst O,
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Gansevoort RT,
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Perrone RD,
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Koch G,
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Ouyang J,
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McQuade RD,
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Blais JD,
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Czerwiec FS,
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Sergeyeva O;
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REPRISE Trial Investigators</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2017 Nov 16;377(20):1930-1942.
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<span class="bold">PMID: </span><a href="/pubmed/29105594" target="_blank">29105594</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24904092">Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Irazabal MV,
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Rangel LJ,
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Bergstralh EJ,
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Osborn SL,
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Harmon AJ,
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Sundsbak JL,
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Bae KT,
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Chapman AB,
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Grantham JJ,
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Mrug M,
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Hogan MC,
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El-Zoghby ZM,
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Harris PC,
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Erickson BJ,
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King BF,
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Torres VE;
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CRISP Investigators</span><br />
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<span class="medgenPMjournal">J Am Soc Nephrol</span>
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2015 Jan;26(1):160-72.
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Epub 2014 Jun 5
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doi: 10.1681/ASN.2013101138.
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<span class="bold">PMID: </span><a href="/pubmed/24904092" target="_blank">24904092</a><a href="/pmc/articles/PMC4279733" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/23121377">Tolvaptan in patients with autosomal dominant polycystic kidney disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Torres VE,
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Chapman AB,
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Devuyst O,
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Gansevoort RT,
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Grantham JJ,
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Higashihara E,
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Perrone RD,
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Krasa HB,
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Ouyang J,
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Czerwiec FS;
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TEMPO 3:4 Trial Investigators</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2012 Dec 20;367(25):2407-18.
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Epub 2012 Nov 3
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<span class="bold">PMID: </span><a href="/pubmed/23121377" target="_blank">23121377</a><a href="/pmc/articles/PMC3760207" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (845)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/32690722">Insights into Autosomal Dominant Polycystic Kidney Disease from Genetic Studies.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lanktree MB,
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Haghighi A,
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di Bari I,
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Song X,
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Pei Y</span><br />
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<span class="medgenPMjournal">Clin J Am Soc Nephrol</span>
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||
2021 May 8;16(5):790-799.
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Epub 2020 Jul 20
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doi: 10.2215/CJN.02320220.
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<span class="bold">PMID: </span><a href="/pubmed/32690722" target="_blank">32690722</a><a href="/pmc/articles/PMC8259493" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30819518">Autosomal dominant polycystic kidney disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cornec-Le Gall E,
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Alam A,
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Perrone RD</span><br />
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<span class="medgenPMjournal">Lancet</span>
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2019 Mar 2;393(10174):919-935.
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Epub 2019 Feb 25
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doi: 10.1016/S0140-6736(18)32782-X.
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<span class="bold">PMID: </span><a href="/pubmed/30819518" target="_blank">30819518</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26453610">Refining Genotype-Phenotype Correlation in Autosomal Dominant Polycystic Kidney Disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hwang YH,
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Conklin J,
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Chan W,
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Roslin NM,
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Liu J,
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He N,
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Wang K,
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Sundsbak JL,
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Heyer CM,
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Haider M,
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Paterson AD,
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Harris PC,
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Pei Y</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/24904092">Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Irazabal MV,
|
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Rangel LJ,
|
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Bergstralh EJ,
|
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Osborn SL,
|
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Harmon AJ,
|
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Sundsbak JL,
|
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Bae KT,
|
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Chapman AB,
|
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Grantham JJ,
|
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Mrug M,
|
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Hogan MC,
|
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El-Zoghby ZM,
|
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Harris PC,
|
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Erickson BJ,
|
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King BF,
|
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Torres VE;
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CRISP Investigators</span><br />
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<span class="medgenPMjournal">J Am Soc Nephrol</span>
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2015 Jan;26(1):160-72.
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Epub 2014 Jun 5
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doi: 10.1681/ASN.2013101138.
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<span class="bold">PMID: </span><a href="/pubmed/24904092" target="_blank">24904092</a><a href="/pmc/articles/PMC4279733" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23121377">Tolvaptan in patients with autosomal dominant polycystic kidney disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Torres VE,
|
||
Chapman AB,
|
||
Devuyst O,
|
||
Gansevoort RT,
|
||
Grantham JJ,
|
||
Higashihara E,
|
||
Perrone RD,
|
||
Krasa HB,
|
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Ouyang J,
|
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Czerwiec FS;
|
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TEMPO 3:4 Trial Investigators</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
|
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2012 Dec 20;367(25):2407-18.
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Epub 2012 Nov 3
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doi: 10.1056/NEJMoa1205511.
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<span class="bold">PMID: </span><a href="/pubmed/23121377" target="_blank">23121377</a><a href="/pmc/articles/PMC3760207" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (941)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/33940108">Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Burgmaier K,
|
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Brinker L,
|
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Erger F,
|
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Beck BB,
|
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Benz MR,
|
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Bergmann C,
|
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Boyer O,
|
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Collard L,
|
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Dafinger C,
|
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Fila M,
|
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Kowalewska C,
|
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Lange-Sperandio B,
|
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Massella L,
|
||
Mastrangelo A,
|
||
Mekahli D,
|
||
Miklaszewska M,
|
||
Ortiz-Bruechle N,
|
||
Patzer L,
|
||
Prikhodina L,
|
||
Ranchin B,
|
||
Ranguelov N,
|
||
Schild R,
|
||
Seeman T,
|
||
Sever L,
|
||
Sikora P,
|
||
Szczepanska M,
|
||
Teixeira A,
|
||
Thumfart J,
|
||
Uetz B,
|
||
Weber LT,
|
||
Wühl E,
|
||
Zerres K;
|
||
ESCAPE Study group;
|
||
GPN study group,
|
||
Dötsch J,
|
||
Schaefer F,
|
||
Liebau MC;
|
||
ARegPKD consortium</span><br />
|
||
<span class="medgenPMjournal">Kidney Int</span>
|
||
2021 Sep;100(3):650-659.
|
||
Epub 2021 Apr 30
|
||
doi: 10.1016/j.kint.2021.04.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33940108" target="_blank">33940108</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32450155">Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutations in UMOD and MUC1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Olinger E,
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Hofmann P,
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Kidd K,
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Dufour I,
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Belge H,
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Kipp A,
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Bonny O,
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Deltas C,
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Demoulin N,
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Fehr T,
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Fuster DG,
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Gale DP,
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Goffin E,
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Hodaňová K,
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Huynh-Do U,
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Kistler A,
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Morelle J,
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Papagregoriou G,
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Pirson Y,
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Torra R,
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<div class="nl"><a target="_blank" href="/pubmed/26150605">The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/24904092">Imaging classification of autosomal dominant polycystic kidney disease: a simple model for selecting patients for clinical trials.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Irazabal MV,
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Rangel LJ,
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Bergstralh EJ,
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Osborn SL,
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Harmon AJ,
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Sundsbak JL,
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Bae KT,
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Chapman AB,
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Grantham JJ,
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Mrug M,
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Hogan MC,
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El-Zoghby ZM,
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Harris PC,
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Erickson BJ,
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King BF,
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Torres VE;
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CRISP Investigators</span><br />
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<span class="medgenPMjournal">J Am Soc Nephrol</span>
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2015 Jan;26(1):160-72.
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Epub 2014 Jun 5
|
||
doi: 10.1681/ASN.2013101138.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24904092" target="_blank">24904092</a><a href="/pmc/articles/PMC4279733" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18607645">Nephronophthisis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salomon R,
|
||
Saunier S,
|
||
Niaudet P</span><br />
|
||
<span class="medgenPMjournal">Pediatr Nephrol</span>
|
||
2009 Dec;24(12):2333-44.
|
||
Epub 2008 Jul 8
|
||
doi: 10.1007/s00467-008-0840-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18607645" target="_blank">18607645</a><a href="/pmc/articles/PMC2770134" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (962)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37870148">Synbiotics, prebiotics and probiotics for people with chronic kidney disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cooper TE,
|
||
Khalid R,
|
||
Chan S,
|
||
Craig JC,
|
||
Hawley CM,
|
||
Howell M,
|
||
Johnson DW,
|
||
Jaure A,
|
||
Teixeira-Pinto A,
|
||
Wong G</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Oct 23;10(10):CD013631.
|
||
doi: 10.1002/14651858.CD013631.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37870148" target="_blank">37870148</a><a href="/pmc/articles/PMC10591284" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37150675">The safety and efficacy of tolvaptan in the treatment of patients with autosomal dominant polycystic kidney disease: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li X,
|
||
Li W,
|
||
Li Y,
|
||
Dong C,
|
||
Zhu P</span><br />
|
||
<span class="medgenPMjournal">Nefrologia (Engl Ed)</span>
|
||
2023 Nov-Dec;43(6):731-741.
|
||
Epub 2023 May 5
|
||
doi: 10.1016/j.nefroe.2023.04.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37150675" target="_blank">37150675</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37088530">Patient Perspectives on ADPKD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gittus M,
|
||
Harris T,
|
||
Ong AC</span><br />
|
||
<span class="medgenPMjournal">Adv Kidney Dis Health</span>
|
||
2023 May;30(3):294-302.
|
||
doi: 10.1053/j.akdh.2023.01.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37088530" target="_blank">37088530</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27553859">Outcomes associated with fetal hepatobiliary cysts: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leombroni M,
|
||
Buca D,
|
||
Celentano C,
|
||
Liberati M,
|
||
Bascietto F,
|
||
Gustapane S,
|
||
Marrone L,
|
||
Manzoli L,
|
||
Rizzo G,
|
||
D'Antonio F</span><br />
|
||
<span class="medgenPMjournal">Ultrasound Obstet Gynecol</span>
|
||
2017 Aug;50(2):167-174.
|
||
Epub 2017 Jul 9
|
||
doi: 10.1002/uog.17244.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27553859" target="_blank">27553859</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21641282">Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vlak MH,
|
||
Algra A,
|
||
Brandenburg R,
|
||
Rinkel GJ</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2011 Jul;10(7):626-36.
|
||
doi: 10.1016/S1474-4422(11)70109-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21641282" target="_blank">21641282</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (42)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3887964%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (19)</a></li>
|
||
<li><a href="/gtr/tests?term=C3887964%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (29)</a></li>
|
||
<li><a href="/gtr/tests?term=C3887964%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (11)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3887964%5bDISCUI%5d" target="_blank">See all (30)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=600666" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=104160" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=23193[geneid]" target="_blank">View GANAB variations in ClinVar</a></li><li><a href="https://catalog.coriell.org/Search?q=600666" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/polycystic_kidney_disease_3_with_or_without_polycystic_liver_disease" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/polycystic-kidney-disease" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/18598/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/20301424" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Polycystic%20kidney%20disease%203%20with%20or%20without%20polycystic%20liver%20disease%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=854672" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=854672" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3887964[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3887964[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=854672" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=854672" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=854672" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=854672" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_bookshelf_cited&from_uid=854672" ref="log$=recordlinks">PubMed (Bookshelf cited)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Links to PubMed based on citations in GeneReviews and Medical Genetics Summaries</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_genereviews&from_uid=854672" ref="log$=recordlinks">PubMed (GeneReviews)</a>
|
||
<div class="brieflinkpop offscreen_noflow">GeneReviews in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=854672" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
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|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
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|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
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<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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