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<!--
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UID=854614
|
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ConceptID=C3887896
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Primary adrenal insufficiency</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>854614</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3887896</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Addison disease; Addison's disease; Adrenocortical insufficiency; Primary Adrenal Insufficiency; primary adrenal insufficiency; Primary adrenocortical failure</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008207">HP:0008207</a></td></tr>
|
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<tr><td>Monarch Initiative:</td>
|
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<td><a href="https://monarchinitiative.org/disease/MONDO:0015128" target="_blank">MONDO:0015128</a></td></tr>
|
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<tr><td>Orphanet:</td>
|
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<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=101958">ORPHA101958</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Primary adrenal insufficiency</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/4043" ref="tree=MeSH" title="MedGen record for Disorder of endocrine system">Disorder of endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/155" ref="tree=MeSH" title="MedGen record for Disorder of adrenal gland">Disorder of adrenal gland</a></span><ul><li><span class="TLline"><a href="/medgen/233768" ref="tree=MeSH" title="MedGen record for Non-Neoplastic Adrenal Gland Disorder">Non-Neoplastic Adrenal Gland Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/589758" ref="tree=MeSH" title="MedGen record for Adrenal cortical hypofunction">Adrenal cortical hypofunction</a></span><ul><li><span class="matched_ds">Primary adrenal insufficiency</span><ul><li><span class="TLline"><a href="/medgen/56227" ref="tree=MeSH" title="MedGen record for Acute adrenal insufficiency">Acute adrenal insufficiency</a></span><ul><li><span class="TLline"><a href="/medgen/1843030" ref="tree=MeSH" title="MedGen record for Bilateral massive adrenal hemorrhage">Bilateral massive adrenal hemorrhage</a></span></li><li><span class="TLline"><a href="/medgen/234675" ref="tree=MeSH" title="MedGen record for Waterhouse-Friderichsen syndrome">Waterhouse-Friderichsen syndrome</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1324" ref="tree=MeSH" title="MedGen record for Primary adrenocortical insufficiency">Primary adrenocortical insufficiency</a></span><ul><li><span class="TLline"><a href="/medgen/357032" ref="tree=MeSH" title="MedGen record for Familial Hypoadrenocorticism">Familial Hypoadrenocorticism</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_9618"><div><strong>Kearns-Sayre syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9618</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022541</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Single large-scale mitochondrial DNA deletion syndromes (SLSMDSs) comprise overlapping clinical phenotypes including Kearns-Sayre syndrome (KSS), KSS spectrum, Pearson syndrome (PS), chronic progressive external ophthalmoplegia (CPEO), and CPEO-plus. KSS is a progressive multisystem disorder with onset before age 20 years characterized by pigmentary retinopathy, CPEO, and cardiac conduction abnormality. Additional features can include cerebellar ataxia, tremor, intellectual disability or cognitive decline, dementia, sensorineural hearing loss, oropharyngeal and esophageal dysfunction, exercise intolerance, muscle weakness, and endocrinopathies. Brain imaging typically shows bilateral lesions in the globus pallidus and white matter. KSS spectrum includes individuals with KSS in addition to individuals with ptosis and/or ophthalmoparesis and at least one of the following: retinopathy, ataxia, cardiac conduction defects, hearing loss, growth deficiency, cognitive impairment, tremor, or cardiomyopathy. Compared to CPEO-plus, individuals with KSS spectrum have more severe muscle involvement (e.g., weakness, atrophy) and overall have a worse prognosis. PS is characterized by pancytopenia (typically transfusion-dependent sideroblastic anemia with variable cell line involvement), exocrine pancreatic dysfunction, poor weight gain, and lactic acidosis. PS manifestations also include renal tubular acidosis, short stature, and elevated liver enzymes. PS may be fatal in infancy due to neutropenia-related infection or refractory metabolic acidosis. CPEO is characterized by ptosis, ophthalmoplegia, oropharyngeal weakness, variable proximal limb weakness, and/or exercise intolerance. CPEO-plus includes CPEO with additional multisystemic involvement including neuropathy, diabetes mellitus, migraines, hypothyroidism, neuropsychiatric manifestations, and optic neuropathy. Rarely, an SLSMDS can manifest as Leigh syndrome, which is characterized as developmental delays, neurodevelopmental regression, lactic acidosis, and bilateral symmetric basal ganglia, brain stem, and/or midbrain lesions on MRI.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9618">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_39125"><div><strong>Polyglandular autoimmune syndrome, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39125</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune polyglandular syndrome type I (APS1) is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis (Neufeld et al., 1981). However, variable APS1 phenotypes have been observed, even among sibs. In addition, some patients may exhibit apparent isolated hypoparathyroidism, an early manifestation of APS1 with peak incidence at around age 5 years; over long-term follow-up, the development of additional features of APS1 may be observed (Cranston et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/39125">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_39126"><div><strong>Polyglandular autoimmune syndrome, type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39126</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085860</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune polyendocrine syndrome type II (APS2), or Schmidt syndrome, is characterized by the presence of autoimmune Addison disease in association with either autoimmune thyroid disease or type I diabetes mellitus, or both. Chronic candidiasis is not present. APS2 may occur at any age and in both sexes, but is most common in middle-aged females and is very rare in childhood (summary by Betterle et al., 2004). See 240300 for a phenotypic description of autoimmune polyendocrine syndrome type I (APS1).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/39126">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_57667"><div><strong>Adrenoleukodystrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57667</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0162309</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">X-linked adrenoleukodystrophy (X-ALD) involves the central or peripheral nervous system and the adrenal cortex. The nervous system and adrenal glands are involved independently; thus, an affected male may be diagnosed with cerebral adrenoleukodystrophy (CALD), adrenomyeloneuropathy (AMN), and/or primary adrenocortical insufficiency. CALD is characterized by progressive behavioral, cognitive, and neurologic deficits; onset of symptoms ranges from childhood (typically ages 4 to 8 years) to adolescence (ages 11 to 21 years) and adulthood. AMN is characterized by leg weakness, spasticity, clumsy gait, pain, and bladder and bowel dysfunction; onset is typically in the 20s and 30s. Onset of primary adrenocortical insufficiency ranges from age two years to adulthood (most commonly by age 7.5 years). Heterozygous females are not at increased risk to develop CALD, but are at increased risk to develop AMN and primary adrenocortical insufficiency with increasing age.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57667">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_87442"><div><strong>Congenital adrenal hypoplasia, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87442</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0342482</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">NR0B1-related adrenal hypoplasia congenita includes both X-linked adrenal hypoplasia congenita (X-linked AHC) and Xp21 deletion (previously called complex glycerol kinase deficiency). X-linked AHC is characterized by primary adrenal insufficiency and/or hypogonadotropic hypogonadism (HH). Adrenal insufficiency is acute infantile onset (average age 3 weeks) in approximately 60% of affected males and childhood onset (ages 1-9 years) in approximately 40%. HH typically manifests in a male with adrenal insufficiency as delayed puberty (i.e., onset age >14 years) and less commonly as arrested puberty at about Tanner Stage 3. Rarely, X-linked AHC manifests initially in early adulthood as delayed-onset adrenal insufficiency, partial HH, and/or infertility. Heterozygous females very occasionally have manifestations of adrenal insufficiency or hypogonadotropic hypogonadism. Xp21 deletion includes deletion of NR0B1 (causing X-linked AHC) and GK (causing glycerol kinase deficiency), and in some cases deletion of DMD (causing Duchenne muscular dystrophy). Developmental delay has been reported in males with Xp21 deletion when the deletion extends proximally to include DMD or when larger deletions extend distally to include IL1RAPL1 and DMD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87442">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_137982"><div><strong>Bifunctional peroxisomal enzyme deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>137982</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0342870</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">D-bifunctional protein deficiency is a disorder of peroxisomal fatty acid beta-oxidation. See also peroxisomal acyl-CoA oxidase deficiency (264470), caused by mutation in the ACOX1 gene (609751) on chromosome 17q25. The clinical manifestations of these 2 deficiencies are similar to those of disorders of peroxisomal assembly, including X-linked adrenoleukodystrophy (ALD; 300100), Zellweger cerebrohepatorenal syndrome (see 214100) and neonatal adrenoleukodystrophy (NALD; see 601539) (Watkins et al., 1995). DBP deficiency has been classified into 3 subtypes depending upon the deficient enzyme activity. Type I is a deficiency of both 2-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase; type II is a deficiency of hydratase activity alone; and type III is a deficiency of dehydrogenase activity alone. Virtually all patients with types I, II, and III have a severe phenotype characterized by infantile-onset of hypotonia, seizures, and abnormal facial features, and most die before age 2 years. McMillan et al. (2012) proposed a type IV deficiency on the basis of less severe features; these patients have a phenotype reminiscent of Perrault syndrome (PRLTS1; 233400). Pierce et al. (2010) noted that Perrault syndrome and DBP deficiency overlap clinically and suggested that DBP deficiency may be underdiagnosed.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/137982">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1631307"><div><strong>Combined oxidative phosphorylation deficiency 34</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1631307</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693450</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">COXPD34 is an autosomal recessive disorder resulting from a defect in mitochondrial function. The phenotype is variable, but may include congenital sensorineural deafness, increased serum lactate, and hepatic and renal dysfunction. Neurologic function is relatively preserved (summary by Menezes et al., 2015). For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (609060).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1631307">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_57667" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Adrenoleukodystrophy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_137982" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bifunctional peroxisomal enzyme deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1631307" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 34</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_87442" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital adrenal hypoplasia, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9618" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kearns-Sayre syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_39125" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyglandular autoimmune syndrome, type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_39126" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyglandular autoimmune syndrome, type 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36958832">Diagnosis and management of adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lewis A,
|
||
Thant AA,
|
||
Aslam A,
|
||
Aung PPM,
|
||
Azmi S</span><br />
|
||
<span class="medgenPMjournal">Clin Med (Lond)</span>
|
||
2023 Mar;23(2):115-118.
|
||
doi: 10.7861/clinmed.2023-0067.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36958832" target="_blank">36958832</a><a href="/pmc/articles/PMC11046533" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32017012">Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woodcock T,
|
||
Barker P,
|
||
Daniel S,
|
||
Fletcher S,
|
||
Wass JAH,
|
||
Tomlinson JW,
|
||
Misra U,
|
||
Dattani M,
|
||
Arlt W,
|
||
Vercueil A</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2020 May;75(5):654-663.
|
||
Epub 2020 Feb 3
|
||
doi: 10.1111/anae.14963.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32017012" target="_blank">32017012</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26760044">Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornstein SR,
|
||
Allolio B,
|
||
Arlt W,
|
||
Barthel A,
|
||
Don-Wauchope A,
|
||
Hammer GD,
|
||
Husebye ES,
|
||
Merke DP,
|
||
Murad MH,
|
||
Stratakis CA,
|
||
Torpy DJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2016 Feb;101(2):364-89.
|
||
Epub 2016 Jan 13
|
||
doi: 10.1210/jc.2015-1710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26760044" target="_blank">26760044</a><a href="/pmc/articles/PMC4880116" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22primary%20adrenal%20insufficiency%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (61)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38296783">Congenital Adrenal Hyperplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fraga NR,
|
||
Minaeian N,
|
||
Kim MS</span><br />
|
||
<span class="medgenPMjournal">Pediatr Rev</span>
|
||
2024 Feb 1;45(2):74-84.
|
||
doi: 10.1542/pir.2022-005617.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38296783" target="_blank">38296783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38034003">X-linked adrenoleukodystrophy and primary adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cappa M,
|
||
Todisco T,
|
||
Bizzarri C</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1309053.
|
||
Epub 2023 Nov 16
|
||
doi: 10.3389/fendo.2023.1309053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38034003" target="_blank">38034003</a><a href="/pmc/articles/PMC10687143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32063488">Autoimmune Addison's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saverino S,
|
||
Falorni A</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
|
||
2020 Jan;34(1):101379.
|
||
Epub 2020 Jan 30
|
||
doi: 10.1016/j.beem.2020.101379.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32063488" target="_blank">32063488</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32017012">Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woodcock T,
|
||
Barker P,
|
||
Daniel S,
|
||
Fletcher S,
|
||
Wass JAH,
|
||
Tomlinson JW,
|
||
Misra U,
|
||
Dattani M,
|
||
Arlt W,
|
||
Vercueil A</span><br />
|
||
<span class="medgenPMjournal">Anaesthesia</span>
|
||
2020 May;75(5):654-663.
|
||
Epub 2020 Feb 3
|
||
doi: 10.1111/anae.14963.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32017012" target="_blank">32017012</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31610036">Primary adrenal insufficiency: New genetic causes and their long-term consequences.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buonocore F,
|
||
Achermann JC</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2020 Jan;92(1):11-20.
|
||
Epub 2019 Oct 30
|
||
doi: 10.1111/cen.14109.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31610036" target="_blank">31610036</a><a href="/pmc/articles/PMC6916405" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (235)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38296783">Congenital Adrenal Hyperplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fraga NR,
|
||
Minaeian N,
|
||
Kim MS</span><br />
|
||
<span class="medgenPMjournal">Pediatr Rev</span>
|
||
2024 Feb 1;45(2):74-84.
|
||
doi: 10.1542/pir.2022-005617.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38296783" target="_blank">38296783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38034003">X-linked adrenoleukodystrophy and primary adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cappa M,
|
||
Todisco T,
|
||
Bizzarri C</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1309053.
|
||
Epub 2023 Nov 16
|
||
doi: 10.3389/fendo.2023.1309053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38034003" target="_blank">38034003</a><a href="/pmc/articles/PMC10687143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33484633">Adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Husebye ES,
|
||
Pearce SH,
|
||
Krone NP,
|
||
Kämpe O</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2021 Feb 13;397(10274):613-629.
|
||
Epub 2021 Jan 20
|
||
doi: 10.1016/S0140-6736(21)00136-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33484633" target="_blank">33484633</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30562824">An Update on Addison's Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barthel A,
|
||
Benker G,
|
||
Berens K,
|
||
Diederich S,
|
||
Manfras B,
|
||
Gruber M,
|
||
Kanczkowski W,
|
||
Kline G,
|
||
Kamvissi-Lorenz V,
|
||
Hahner S,
|
||
Beuschlein F,
|
||
Brennand A,
|
||
Boehm BO,
|
||
Torpy DJ,
|
||
Bornstein SR</span><br />
|
||
<span class="medgenPMjournal">Exp Clin Endocrinol Diabetes</span>
|
||
2019 Feb;127(2-03):165-175.
|
||
Epub 2018 Dec 18
|
||
doi: 10.1055/a-0804-2715.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30562824" target="_blank">30562824</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26760044">Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bornstein SR,
|
||
Allolio B,
|
||
Arlt W,
|
||
Barthel A,
|
||
Don-Wauchope A,
|
||
Hammer GD,
|
||
Husebye ES,
|
||
Merke DP,
|
||
Murad MH,
|
||
Stratakis CA,
|
||
Torpy DJ</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2016 Feb;101(2):364-89.
|
||
Epub 2016 Jan 13
|
||
doi: 10.1210/jc.2015-1710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26760044" target="_blank">26760044</a><a href="/pmc/articles/PMC4880116" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (471)</a></div><h3 class="subhead">Therapy</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/38296783">Congenital Adrenal Hyperplasia.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fraga NR,
|
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Minaeian N,
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Kim MS</span><br />
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<span class="medgenPMjournal">Pediatr Rev</span>
|
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2024 Feb 1;45(2):74-84.
|
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doi: 10.1542/pir.2022-005617.
|
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<span class="bold">PMID: </span><a href="/pubmed/38296783" target="_blank">38296783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38034003">X-linked adrenoleukodystrophy and primary adrenal insufficiency.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Cappa M,
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Todisco T,
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Bizzarri C</span><br />
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<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
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2023;14:1309053.
|
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Epub 2023 Nov 16
|
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doi: 10.3389/fendo.2023.1309053.
|
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<span class="bold">PMID: </span><a href="/pubmed/38034003" target="_blank">38034003</a><a href="/pmc/articles/PMC10687143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32364223">The Changing Face of Adrenoleukodystrophy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhu J,
|
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Eichler F,
|
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Biffi A,
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Duncan CN,
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Williams DA,
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Majzoub JA</span><br />
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<span class="medgenPMjournal">Endocr Rev</span>
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2020 Aug 1;41(4):577-93.
|
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doi: 10.1210/endrev/bnaa013.
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<span class="bold">PMID: </span><a href="/pubmed/32364223" target="_blank">32364223</a><a href="/pmc/articles/PMC7286618" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/32017012">Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: Guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Woodcock T,
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Barker P,
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Daniel S,
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Fletcher S,
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Wass JAH,
|
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Tomlinson JW,
|
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Misra U,
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Dattani M,
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Arlt W,
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Vercueil A</span><br />
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<span class="medgenPMjournal">Anaesthesia</span>
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2020 May;75(5):654-663.
|
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Epub 2020 Feb 3
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doi: 10.1111/anae.14963.
|
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<span class="bold">PMID: </span><a href="/pubmed/32017012" target="_blank">32017012</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31321757">Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Betterle C,
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Presotto F,
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Furmaniak J</span><br />
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<span class="medgenPMjournal">J Endocrinol Invest</span>
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2019 Dec;42(12):1407-1433.
|
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Epub 2019 Jul 18
|
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doi: 10.1007/s40618-019-01079-6.
|
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<span class="bold">PMID: </span><a href="/pubmed/31321757" target="_blank">31321757</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (292)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36175155">International Recommendations for the Diagnosis and Management of Patients With Adrenoleukodystrophy: A Consensus-Based Approach.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Engelen M,
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van Ballegoij WJC,
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Mallack EJ,
|
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Van Haren KP,
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Köhler W,
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Salsano E,
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van Trotsenburg ASP,
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Mochel F,
|
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Sevin C,
|
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Regelmann MO,
|
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Tritos NA,
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Halper A,
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Lachmann RH,
|
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Davison J,
|
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Raymond GV,
|
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Lund TC,
|
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Orchard PJ,
|
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Kuehl JS,
|
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Lindemans CA,
|
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Caruso P,
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Turk BR,
|
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Moser AB,
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Vaz FM,
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Ferdinandusse S,
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Kemp S,
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Fatemi A,
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Eichler FS,
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Huffnagel IC</span><br />
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<span class="medgenPMjournal">Neurology</span>
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2022 Nov 22;99(21):940-951.
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Epub 2022 Sep 29
|
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doi: 10.1212/WNL.0000000000201374.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36175155" target="_blank">36175155</a><a href="/pmc/articles/PMC9687408" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32364223">The Changing Face of Adrenoleukodystrophy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhu J,
|
||
Eichler F,
|
||
Biffi A,
|
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Duncan CN,
|
||
Williams DA,
|
||
Majzoub JA</span><br />
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<span class="medgenPMjournal">Endocr Rev</span>
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2020 Aug 1;41(4):577-93.
|
||
doi: 10.1210/endrev/bnaa013.
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<span class="bold">PMID: </span><a href="/pubmed/32364223" target="_blank">32364223</a><a href="/pmc/articles/PMC7286618" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31321757">Epidemiology, pathogenesis, and diagnosis of Addison's disease in adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Betterle C,
|
||
Presotto F,
|
||
Furmaniak J</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2019 Dec;42(12):1407-1433.
|
||
Epub 2019 Jul 18
|
||
doi: 10.1007/s40618-019-01079-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31321757" target="_blank">31321757</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28973656">Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barroso-Sousa R,
|
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Barry WT,
|
||
Garrido-Castro AC,
|
||
Hodi FS,
|
||
Min L,
|
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Krop IE,
|
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Tolaney SM</span><br />
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<span class="medgenPMjournal">JAMA Oncol</span>
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2018 Feb 1;4(2):173-182.
|
||
doi: 10.1001/jamaoncol.2017.3064.
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||
<span class="bold">PMID: </span><a href="/pubmed/28973656" target="_blank">28973656</a><a href="/pmc/articles/PMC5838579" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24330030">Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Husebye ES,
|
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Allolio B,
|
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Arlt W,
|
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Badenhoop K,
|
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Bensing S,
|
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Betterle C,
|
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Falorni A,
|
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Gan EH,
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Hulting AL,
|
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Kasperlik-Zaluska A,
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Kämpe O,
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Løvås K,
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Meyer G,
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Pearce SH</span><br />
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<span class="medgenPMjournal">J Intern Med</span>
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2014 Feb;275(2):104-15.
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Epub 2013 Dec 16
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||
doi: 10.1111/joim.12162.
|
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<span class="bold">PMID: </span><a href="/pubmed/24330030" target="_blank">24330030</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (142)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38034003">X-linked adrenoleukodystrophy and primary adrenal insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cappa M,
|
||
Todisco T,
|
||
Bizzarri C</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1309053.
|
||
Epub 2023 Nov 16
|
||
doi: 10.3389/fendo.2023.1309053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38034003" target="_blank">38034003</a><a href="/pmc/articles/PMC10687143" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36175155">International Recommendations for the Diagnosis and Management of Patients With Adrenoleukodystrophy: A Consensus-Based Approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Engelen M,
|
||
van Ballegoij WJC,
|
||
Mallack EJ,
|
||
Van Haren KP,
|
||
Köhler W,
|
||
Salsano E,
|
||
van Trotsenburg ASP,
|
||
Mochel F,
|
||
Sevin C,
|
||
Regelmann MO,
|
||
Tritos NA,
|
||
Halper A,
|
||
Lachmann RH,
|
||
Davison J,
|
||
Raymond GV,
|
||
Lund TC,
|
||
Orchard PJ,
|
||
Kuehl JS,
|
||
Lindemans CA,
|
||
Caruso P,
|
||
Turk BR,
|
||
Moser AB,
|
||
Vaz FM,
|
||
Ferdinandusse S,
|
||
Kemp S,
|
||
Fatemi A,
|
||
Eichler FS,
|
||
Huffnagel IC</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2022 Nov 22;99(21):940-951.
|
||
Epub 2022 Sep 29
|
||
doi: 10.1212/WNL.0000000000201374.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36175155" target="_blank">36175155</a><a href="/pmc/articles/PMC9687408" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35633647">Autoimmune Primary Adrenal Insufficiency in Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mourinho Bala N,
|
||
Gonçalves RS,
|
||
Serra Caetano J,
|
||
Cardoso R,
|
||
Dinis I,
|
||
Mirante A</span><br />
|
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<span class="medgenPMjournal">J Clin Res Pediatr Endocrinol</span>
|
||
2022 Aug 25;14(3):308-312.
|
||
Epub 2022 May 31
|
||
doi: 10.4274/jcrpe.galenos.2022.2021-11-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35633647" target="_blank">35633647</a><a href="/pmc/articles/PMC9422918" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35254428">Should Dehydroepiandrosterone Be Administered to Women?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wierman ME,
|
||
Kiseljak-Vassiliades K</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2022 May 17;107(6):1679-1685.
|
||
doi: 10.1210/clinem/dgac130.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35254428" target="_blank">35254428</a><a href="/pmc/articles/PMC9113789" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30861560">A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de Filette J,
|
||
Andreescu CE,
|
||
Cools F,
|
||
Bravenboer B,
|
||
Velkeniers B</span><br />
|
||
<span class="medgenPMjournal">Horm Metab Res</span>
|
||
2019 Mar;51(3):145-156.
|
||
Epub 2019 Mar 12
|
||
doi: 10.1055/a-0843-3366.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30861560" target="_blank">30861560</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (139)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36313775">Vitamin D and adrenal gland: Myth or reality? A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al Refaie A,
|
||
Baldassini L,
|
||
De Vita M,
|
||
Gonnelli S,
|
||
Caffarelli C</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2022;13:1001065.
|
||
Epub 2022 Oct 13
|
||
doi: 10.3389/fendo.2022.1001065.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36313775" target="_blank">36313775</a><a href="/pmc/articles/PMC9606701" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33554872">Immune Checkpoint Inhibitor-Induced Adrenalitis and Primary Adrenal Insufficiency: Systematic Review and Optimal Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shi Y,
|
||
Shen M,
|
||
Zheng X,
|
||
Yang T</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2021 Feb;27(2):165-169.
|
||
Epub 2020 Dec 16
|
||
doi: 10.1016/j.eprac.2020.09.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33554872" target="_blank">33554872</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30861560">A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">de Filette J,
|
||
Andreescu CE,
|
||
Cools F,
|
||
Bravenboer B,
|
||
Velkeniers B</span><br />
|
||
<span class="medgenPMjournal">Horm Metab Res</span>
|
||
2019 Mar;51(3):145-156.
|
||
Epub 2019 Mar 12
|
||
doi: 10.1055/a-0843-3366.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30861560" target="_blank">30861560</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29156052">Primary Adrenal Insufficiency: Managing Mineralocorticoid Replacement Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Esposito D,
|
||
Pasquali D,
|
||
Johannsson G</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2018 Feb 1;103(2):376-387.
|
||
doi: 10.1210/jc.2017-01928.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29156052" target="_blank">29156052</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28973656">Incidence of Endocrine Dysfunction Following the Use of Different Immune Checkpoint Inhibitor Regimens: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barroso-Sousa R,
|
||
Barry WT,
|
||
Garrido-Castro AC,
|
||
Hodi FS,
|
||
Min L,
|
||
Krop IE,
|
||
Tolaney SM</span><br />
|
||
<span class="medgenPMjournal">JAMA Oncol</span>
|
||
2018 Feb 1;4(2):173-182.
|
||
doi: 10.1001/jamaoncol.2017.3064.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28973656" target="_blank">28973656</a><a href="/pmc/articles/PMC5838579" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Primary%20adrenal%20insufficiency%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=101958" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Primary%20adrenal%20insufficiency" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22primary%20adrenal%20insufficiency%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Primary%20adrenal%20insufficiency%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
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<title>Facebook</title>
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<p class="address_footer text-white">National Library of Medicine<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
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<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
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<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
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<a class="text-white" href="https://www.nih.gov/">NIH</a>
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