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<meta name="keywords" content="C0266054, accelerated tooth eruption, advanced dental eruption, advanced eruption of teeth, advanced tooth eruption, early dental eruption, early eruption of teeth, eruption, advanced, finding, precocious dentition, precocious tooth eruption, premature dental eruption, premature eruption of teeth, premature tooth eruption, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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ConceptID=C0266054
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Advanced eruption of teeth</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78588</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0266054</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Premature eruption of teeth; Premature tooth eruption</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Premature tooth eruption (16000003); Precocious dentition (16000003); Accelerated tooth eruption (16000003); Precocious tooth eruption (16000003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006288">HP:0006288</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Advanced eruption of teeth</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/6447" ref="tree=MeSH" title="MedGen record for Abnormality of the mouth">Abnormality of the mouth</a></span><ul><li><span class="TLline"><a href="/medgen/1645271" ref="tree=MeSH" title="MedGen record for Abnormal oral morphology">Abnormal oral morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871391" ref="tree=MeSH" title="MedGen record for Abnormal oral cavity morphology">Abnormal oral cavity morphology</a></span><ul><li><span class="TLline"><a href="/medgen/78084" ref="tree=MeSH" title="MedGen record for Abnormality of the dentition">Abnormality of the dentition</a></span><ul><li><span class="TLline"><a href="/medgen/349149" ref="tree=MeSH" title="MedGen record for Abnormality of dental eruption">Abnormality of dental eruption</a></span><ul><li><span class="matched_ds">Advanced eruption of teeth</span><ul><li><span class="TLline"><a href="/medgen/10268" ref="tree=MeSH" title="MedGen record for Natal tooth">Natal tooth</a></span></li><li><span class="TLline"><a href="/medgen/867242" ref="tree=MeSH" title="MedGen record for Premature eruption of permanent teeth">Premature eruption of permanent teeth</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_61232"><div><strong>Sotos syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>61232</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C0175695</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Sotos syndrome is characterized by a distinctive facial appearance (broad and prominent forehead with a dolichocephalic head shape, sparse frontotemporal hair, downslanting palpebral fissures, malar flushing, long and narrow face, long chin); learning disability (early developmental delay, mild-to-severe intellectual impairment); and overgrowth (height and/or head circumference =2 SD above the mean). These three clinical features are considered the cardinal features of Sotos syndrome. Major features of Sotos syndrome include behavioral findings (most notably autistic spectrum disorder), advanced bone age, cardiac anomalies, cranial MRI/CT abnormalities, joint hyperlaxity with or without pes planus, maternal preeclampsia, neonatal complications, renal anomalies, scoliosis, and seizures.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/61232">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_78783"><div><strong>Rabson-Mendenhall syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78783</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0271695</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">INSR-related severe insulin resistance syndrome (INSR-SIRS) comprises a phenotypic spectrum that is a continuum from the severe phenotype of Donohue syndrome to the milder phenotype of Rabson-Mendenhall syndrome (RMS). Donohue syndrome is characterized by severe insulin resistance (hyperinsulinemia with associated fasting hypoglycemia and postprandial hyperglycemia), severe prenatal growth restriction, postnatal growth failure, hypotonia, developmental delay, characteristic facies (proptosis, infraorbital folds, large, low-set, posteriorly rotated ears, thick vermilion of the upper and lower lips, and gingival hypertrophy), and organomegaly involving the heart, kidneys, liver, spleen, and ovaries. Death usually occurs before age one year. RMS, at the milder end of the spectrum, is characterized by severe insulin resistance that, although not as severe as that of Donohue syndrome, is nonetheless accompanied by fluctuations in blood glucose levels, diabetic ketoacidosis, and in the second decade microvascular complications. Findings can range from severe growth delay and intellectual disability to normal growth and development. Facial features can be milder than those of Donohue syndrome. Complications of longstanding hyperglycemia are the most common cause of death. While death usually occurs in the second decade, some affected individuals live longer.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/78783">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_766574"><div><strong>Malan overgrowth syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766574</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3553660</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">NFIX-related Malan syndrome (MALNS) is characterized by prenatal and postnatal overgrowth, macrocephaly, advanced bone age and/or skeletal anomalies (scoliosis, pes planus), slender body habitus, developmental delay / intellectual disability (typically in the moderate-to-severe range), behavioral problems (including a specific anxious profile and attention-deficit/hyperactivity disorder [ADHD]), and ocular findings (most commonly strabismus, refractive errors, and blue sclerae). Affected individuals typically have distinctive facial features, including a long and triangular face, high anterior hair line with prominent forehead, depressed nasal bridge, deep-set eyes, downslanted palpebral fissures, short nose with anteverted nares and upturned tip, long philtrum, small mouth that is often held open, thin vermilion of the upper lip, an everted lower lip, and a prominent chin. Other findings may include autonomic signs (episodic ataxia with dizziness and nausea and/or postural fainting), seizures or EEG abnormalities, hypotonia, dental anomalies, long bone fractures, and (rarely) congenital heart defects. Four individuals with aortic root dilatation have been reported, with one adult individual experiencing progressive aortic dilation and dissection at age 38 years. Additionally, one individual with rib osteosarcoma and another with Wilms tumor have been reported (an overall prevalence of malignancy of about 2%). Therefore, MALNS appears to be in the same low risk group as Sotos syndrome and Weaver syndrome with respect to a low likelihood of developing cancer.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/766574">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_862975"><div><strong>ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862975</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4014538</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">ADNP-related disorder is characterized by hypotonia, severe speech and motor delay, mild-to-severe intellectual disability, and characteristic facial features (prominent forehead, high anterior hairline, wide and depressed nasal bridge, and short nose with full, upturned nasal tip) based on a cohort of 78 individuals. Features of autism spectrum disorder are common (stereotypic behavior, impaired social interaction). Other common findings include additional behavioral problems, sleep disturbance, brain abnormalities, seizures, feeding issues, gastrointestinal problems, visual dysfunction (hypermetropia, strabismus, cortical visual impairment), musculoskeletal anomalies, endocrine issues including short stature and hormonal deficiencies, cardiac and urinary tract anomalies, and hearing loss.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/862975">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1647077"><div><strong>Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1647077</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4693405</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features (NEDMAGA) is characterized by infantile-onset global developmental delay with severe to profound intellectual disability, mildly delayed walking with broad-based and unsteady gait, and absence of meaningful language. Patients have features of autism, with repetitive behaviors and poor communication, but usually are socially reactive and have a happy demeanor. More variable neurologic features include mild seizures, spasticity, and peripheral neuropathy (summary by Palmer et al., 2017).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1647077">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1744234"><div><strong>Chromosome 13q33-q34 deletion syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1744234</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5436890</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Chromosome 13q33-q34 deletion syndrome is associated with developmental delay and/or impaired intellectual development, facial dysmorphism, and an increased risk for epilepsy, cardiac defects and additional anatomic anomalies (summary by Sagi-Dain et al., 2019).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1744234">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862975" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1744234" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chromosome 13q33-q34 deletion syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766574" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Malan overgrowth syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1647077" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with movement abnormalities, abnormal gait, and autistic features</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_78783" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rabson-Mendenhall syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_61232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sotos syndrome</a></div></div>
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<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36651386">Is there a better interceptive treatment for unerupted palatally displaced canines? A network meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Araujo VZ,
Heckmann S,
Araujo FB,
Casagrande L,
Ziegelmann PK,
Araújo EA,
Marques LS,
Lenzi TL</span><br />
<span class="medgenPMjournal">Braz Oral Res</span>
2023;36:e119.
Epub 2023 Jan 16
doi: 10.1590/1807-3107bor-2022.vol36.0119.
<span class="bold">PMID: </span><a href="/pubmed/36651386" target="_blank">36651386</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33783090">Occlusal Vertical Dimension: Best Evidence Consensus Statement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goldstein G,
Goodacre C,
MacGregor K</span><br />
<span class="medgenPMjournal">J Prosthodont</span>
2021 Apr;30(S1):12-19.
doi: 10.1111/jopr.13315.
<span class="bold">PMID: </span><a href="/pubmed/33783090" target="_blank">33783090</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26545754">Whole Tooth Regeneration as a Future Dental Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Oshima M,
Tsuji T</span><br />
<span class="medgenPMjournal">Adv Exp Med Biol</span>
2015;881:255-69.
doi: 10.1007/978-3-319-22345-2_14.
<span class="bold">PMID: </span><a href="/pubmed/26545754" target="_blank">26545754</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(advanced%20eruption%20of%20teeth)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/32968775">Influence of BMI percentile on craniofacial morphology and development in children and adolescents.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Danze A,
Jacox LA,
Bocklage C,
Whitley J,
Moss K,
Hardigan P,
Garcia-Godoy CE,
Jackson TH</span><br />
<span class="medgenPMjournal">Eur J Orthod</span>
2021 Apr 3;43(2):184-192.
doi: 10.1093/ejo/cjaa056.
<span class="bold">PMID: </span><a href="/pubmed/32968775" target="_blank">32968775</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29525925">Outcomes of autotransplanted teeth and prognostic factors: a 10-year retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yang S,
Jung BY,
Pang NS</span><br />
<span class="medgenPMjournal">Clin Oral Investig</span>
2019 Jan;23(1):87-98.
Epub 2018 Mar 10
doi: 10.1007/s00784-018-2412-3.
<span class="bold">PMID: </span><a href="/pubmed/29525925" target="_blank">29525925</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25075777">Long-term surgical versus functional Class II correction: a comparison of identical twins.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chhibber A,
Upadhyay M,
Uribe F,
Nanda R</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
2015 Jan;85(1):142-56.
doi: 10.2319/011314-46.1.
<span class="bold">PMID: </span><a href="/pubmed/25075777" target="_blank">25075777</a><a href="/pmc/articles/PMC8634819" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9566011">Sealants and preventive restorations: review of effectiveness and clinical changes for improvement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feigal RJ</span><br />
<span class="medgenPMjournal">Pediatr Dent</span>
1998 Mar-Apr;20(2):85-92.
<span class="bold">PMID: </span><a href="/pubmed/9566011" target="_blank">9566011</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9563351">Pain-free and mobility-free orthodontics?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Blechman AM</span><br />
<span class="medgenPMjournal">Am J Orthod Dentofacial Orthop</span>
1998 Apr;113(4):379-83.
<span class="bold">PMID: </span><a href="/pubmed/9563351" target="_blank">9563351</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (92)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/38128337">Global variations in eruption chronology of primary teeth: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Muthu MS,
Vandana S,
Akila G,
Anusha M,
Kandaswamy D,
Aswath Narayanan MB</span><br />
<span class="medgenPMjournal">Arch Oral Biol</span>
2024 Feb;158:105857.
Epub 2023 Dec 6
doi: 10.1016/j.archoralbio.2023.105857.
<span class="bold">PMID: </span><a href="/pubmed/38128337" target="_blank">38128337</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33783090">Occlusal Vertical Dimension: Best Evidence Consensus Statement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goldstein G,
Goodacre C,
MacGregor K</span><br />
<span class="medgenPMjournal">J Prosthodont</span>
2021 Apr;30(S1):12-19.
doi: 10.1111/jopr.13315.
<span class="bold">PMID: </span><a href="/pubmed/33783090" target="_blank">33783090</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19119174">A patient with severe wear on the posterior teeth and minimal wear on the anterior teeth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spear F</span><br />
<span class="medgenPMjournal">J Am Dent Assoc</span>
2009 Jan;140(1):99-104.
doi: 10.14219/jada.archive.2009.0025.
<span class="bold">PMID: </span><a href="/pubmed/19119174" target="_blank">19119174</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18832276">A patient with severe wear on the anterior teeth and minimal wear on the posterior teeth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spear F</span><br />
<span class="medgenPMjournal">J Am Dent Assoc</span>
2008 Oct;139(10):1399-403.
doi: 10.14219/jada.archive.2008.0052.
<span class="bold">PMID: </span><a href="/pubmed/18832276" target="_blank">18832276</a></div>
<div class="nl"><a target="_blank" href="/pubmed/4529184">Tooth size and tooth formation in children with advanced hypodontia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rune B,
Sarnäs KV</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
1974 Oct;44(4):316-21.
doi: 10.1043/0003-3219(1974)044&lt;0316:TSATFI&gt;2.0.CO;2.
<span class="bold">PMID: </span><a href="/pubmed/4529184" target="_blank">4529184</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (34)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38426348">Global variations in eruption chronology of permanent teeth: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vandana S,
Muthu MS,
Akila G,
Anusha M,
Kandaswamy D,
Aswath Narayanan MB</span><br />
<span class="medgenPMjournal">Am J Hum Biol</span>
2024 Aug;36(8):e24060.
Epub 2024 Mar 1
doi: 10.1002/ajhb.24060.
<span class="bold">PMID: </span><a href="/pubmed/38426348" target="_blank">38426348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33783090">Occlusal Vertical Dimension: Best Evidence Consensus Statement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goldstein G,
Goodacre C,
MacGregor K</span><br />
<span class="medgenPMjournal">J Prosthodont</span>
2021 Apr;30(S1):12-19.
doi: 10.1111/jopr.13315.
<span class="bold">PMID: </span><a href="/pubmed/33783090" target="_blank">33783090</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18832276">A patient with severe wear on the anterior teeth and minimal wear on the posterior teeth.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spear F</span><br />
<span class="medgenPMjournal">J Am Dent Assoc</span>
2008 Oct;139(10):1399-403.
doi: 10.14219/jada.archive.2008.0052.
<span class="bold">PMID: </span><a href="/pubmed/18832276" target="_blank">18832276</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17532927">Advanced concepts in implant dentistry: creating the "aesthetic site foundation".</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elian N,
Ehrlich B,
Jalbout ZN,
Classi AJ,
Cho SC,
Kamer AR,
Froum S,
Tarnow DP</span><br />
<span class="medgenPMjournal">Dent Clin North Am</span>
2007 Apr;51(2):547-63, xi-xii.
doi: 10.1016/j.cden.2007.03.001.
<span class="bold">PMID: </span><a href="/pubmed/17532927" target="_blank">17532927</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9563351">Pain-free and mobility-free orthodontics?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Blechman AM</span><br />
<span class="medgenPMjournal">Am J Orthod Dentofacial Orthop</span>
1998 Apr;113(4):379-83.
<span class="bold">PMID: </span><a href="/pubmed/9563351" target="_blank">9563351</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29525925">Outcomes of autotransplanted teeth and prognostic factors: a 10-year retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yang S,
Jung BY,
Pang NS</span><br />
<span class="medgenPMjournal">Clin Oral Investig</span>
2019 Jan;23(1):87-98.
Epub 2018 Mar 10
doi: 10.1007/s00784-018-2412-3.
<span class="bold">PMID: </span><a href="/pubmed/29525925" target="_blank">29525925</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25075777">Long-term surgical versus functional Class II correction: a comparison of identical twins.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chhibber A,
Upadhyay M,
Uribe F,
Nanda R</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
2015 Jan;85(1):142-56.
doi: 10.2319/011314-46.1.
<span class="bold">PMID: </span><a href="/pubmed/25075777" target="_blank">25075777</a><a href="/pmc/articles/PMC8634819" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22475327">How to predict the timing of eruption of mandibular second premolars.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Lima EM,
Schmidt CB,
de Araujo LL,
Rizzatto SM,
Martinelli FL</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
2012 Nov;82(6):1067-70.
Epub 2012 Apr 4
doi: 10.2319/092111-600.1.
<span class="bold">PMID: </span><a href="/pubmed/22475327" target="_blank">22475327</a><a href="/pmc/articles/PMC8813129" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17532927">Advanced concepts in implant dentistry: creating the "aesthetic site foundation".</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elian N,
Ehrlich B,
Jalbout ZN,
Classi AJ,
Cho SC,
Kamer AR,
Froum S,
Tarnow DP</span><br />
<span class="medgenPMjournal">Dent Clin North Am</span>
2007 Apr;51(2):547-63, xi-xii.
doi: 10.1016/j.cden.2007.03.001.
<span class="bold">PMID: </span><a href="/pubmed/17532927" target="_blank">17532927</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9566011">Sealants and preventive restorations: review of effectiveness and clinical changes for improvement.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feigal RJ</span><br />
<span class="medgenPMjournal">Pediatr Dent</span>
1998 Mar-Apr;20(2):85-92.
<span class="bold">PMID: </span><a href="/pubmed/9566011" target="_blank">9566011</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38378499">Forced eruption in impacted teeth: analysis of failed cases and outcome of re-operation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kim J,
Jung S,
Lee KJ,
Yu HS,
Park W</span><br />
<span class="medgenPMjournal">BMC Oral Health</span>
2024 Feb 20;24(1):254.
doi: 10.1186/s12903-024-03963-x.
<span class="bold">PMID: </span><a href="/pubmed/38378499" target="_blank">38378499</a><a href="/pmc/articles/PMC10877739" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33388202">Three-dimensional mandibular dental changes with aging.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Garib D,
Miranda F,
Massaro C,
Lauris JRP,
Yatabe MS,
Janson G,
McNamara JA Jr,
Behrents RG,
Cevidanes LHS,
Ruellas ACO</span><br />
<span class="medgenPMjournal">Am J Orthod Dentofacial Orthop</span>
2021 Feb;159(2):184-192.
Epub 2020 Dec 31
doi: 10.1016/j.ajodo.2019.12.021.
<span class="bold">PMID: </span><a href="/pubmed/33388202" target="_blank">33388202</a><a href="/pmc/articles/PMC7878970" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29525925">Outcomes of autotransplanted teeth and prognostic factors: a 10-year retrospective study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yang S,
Jung BY,
Pang NS</span><br />
<span class="medgenPMjournal">Clin Oral Investig</span>
2019 Jan;23(1):87-98.
Epub 2018 Mar 10
doi: 10.1007/s00784-018-2412-3.
<span class="bold">PMID: </span><a href="/pubmed/29525925" target="_blank">29525925</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22475327">How to predict the timing of eruption of mandibular second premolars.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">de Lima EM,
Schmidt CB,
de Araujo LL,
Rizzatto SM,
Martinelli FL</span><br />
<span class="medgenPMjournal">Angle Orthod</span>
2012 Nov;82(6):1067-70.
Epub 2012 Apr 4
doi: 10.2319/092111-600.1.
<span class="bold">PMID: </span><a href="/pubmed/22475327" target="_blank">22475327</a><a href="/pmc/articles/PMC8813129" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/17532927">Advanced concepts in implant dentistry: creating the "aesthetic site foundation".</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Elian N,
Ehrlich B,
Jalbout ZN,
Classi AJ,
Cho SC,
Kamer AR,
Froum S,
Tarnow DP</span><br />
<span class="medgenPMjournal">Dent Clin North Am</span>
2007 Apr;51(2):547-63, xi-xii.
doi: 10.1016/j.cden.2007.03.001.
<span class="bold">PMID: </span><a href="/pubmed/17532927" target="_blank">17532927</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/38426348">Global variations in eruption chronology of permanent teeth: A systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Vandana S,
Muthu MS,
Akila G,
Anusha M,
Kandaswamy D,
Aswath Narayanan MB</span><br />
<span class="medgenPMjournal">Am J Hum Biol</span>
2024 Aug;36(8):e24060.
Epub 2024 Mar 1
doi: 10.1002/ajhb.24060.
<span class="bold">PMID: </span><a href="/pubmed/38426348" target="_blank">38426348</a></div>
<div class="nl"><a target="_blank" href="/pubmed/38128337">Global variations in eruption chronology of primary teeth: A systematic review and meta-analysis.</a></div>
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<span class="medgenPMjournal">Arch Oral Biol</span>
2024 Feb;158:105857.
Epub 2023 Dec 6
doi: 10.1016/j.archoralbio.2023.105857.
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2024 Mar 1;29(2):e241-e247.
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<div class="nl"><a target="_blank" href="/pubmed/36651386">Is there a better interceptive treatment for unerupted palatally displaced canines? A network meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Furquim CP,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Advanced%20eruption%20of%20teeth%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
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