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<meta name="keywords" content="C0264393, alveolar emphysema of lung, disease or syndrome, emphysema, panacinar, emphysema, panlobular, emphysemas, panacinar, emphysemas, panlobular, panacinar emphysema, panacinar emphysemas, panlobular emphysema, panlobular emphysemas, vesicular emphysema, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=78106
|
||
ConceptID=C0264393
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Panacinar emphysema</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78106</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0264393</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Emphysema, Panacinar; Emphysema, Panlobular; Emphysemas, Panacinar; Emphysemas, Panlobular; Panacinar Emphysema; Panacinar Emphysemas; Panlobular Emphysema; Panlobular Emphysemas</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Panacinar emphysema (4981000); Panlobular emphysema (4981000); Vesicular emphysema (4981000); Alveolar emphysema of lung (4981000)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0032967">HP:0032967</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Panacinar emphysema</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/866322" ref="tree=MeSH" title="MedGen record for Abnormality of the respiratory system">Abnormality of the respiratory system</a></span><ul><li><span class="TLline"><a href="/medgen/220360" ref="tree=MeSH" title="MedGen record for Abnormal respiratory system physiology">Abnormal respiratory system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868593" ref="tree=MeSH" title="MedGen record for Abnormal respiratory system morphology">Abnormal respiratory system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/892303" ref="tree=MeSH" title="MedGen record for Abnormality of the lung">Abnormality of the lung</a></span><ul><li><span class="TLline"><a href="/medgen/18764" ref="tree=MeSH" title="MedGen record for Emphysema">Emphysema</a></span><ul><li><span class="matched_ds">Panacinar emphysema</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_67461"><div><strong>Alpha-1-antitrypsin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>67461</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0221757</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alpha-1 antitrypsin deficiency (AATD) can present with hepatic dysfunction in individuals from infancy to adulthood and with chronic obstructive lung disease (emphysema and/or bronchiectasis), characteristically in individuals older than age 30 years. Individuals with AATD are also at increased risk for panniculitis (migratory, inflammatory, tender skin nodules which may ulcerate on legs and lower abdomen) and C-ANCA-positive vasculitis (granulomatosis with polyangiitis). Phenotypic expression varies within and between families. In adults, smoking is the major factor in accelerating the development of COPD; nonsmokers may have a normal life span, but can also develop lung and/or liver disease. Although reported, emphysema in children with AATD is extremely rare. AATD-associated liver disease, which is present in only a small portion of affected children, manifests as neonatal cholestasis. The incidence of liver disease increases with age. Liver disease in adults (manifesting as cirrhosis and fibrosis) may occur in the absence of a history of neonatal or childhood liver disease. The risk for hepatocellular carcinoma (HCC) is increased in individuals with AATD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/67461">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_67461" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alpha-1-antitrypsin deficiency</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36606685">Safety of Intravenous Administration of an AAV8 Vector Coding for an Oxidation-Resistant Human α1-Antitrypsin for the Treatment of α1-Antitrypsin Deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rosenberg JB,
|
||
De BP,
|
||
Greco A,
|
||
Gorman N,
|
||
Kooner V,
|
||
Chen A,
|
||
Yost-Bido M,
|
||
Munoz-Zuluaga C,
|
||
Kaminsky SM,
|
||
Rostami M,
|
||
Monette S,
|
||
Crystal RG,
|
||
Sondhi D</span><br />
|
||
<span class="medgenPMjournal">Hum Gene Ther</span>
|
||
2023 Feb;34(3-4):139-149.
|
||
doi: 10.1089/hum.2022.192.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36606685" target="_blank">36606685</a><a href="/pmc/articles/PMC9963503" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24191907">Intrapleural administration of an AAVrh.10 vector coding for human α1-antitrypsin for the treatment of α1-antitrypsin deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chiuchiolo MJ,
|
||
Kaminsky SM,
|
||
Sondhi D,
|
||
Hackett NR,
|
||
Rosenberg JB,
|
||
Frenk EZ,
|
||
Hwang Y,
|
||
Van de Graaf BG,
|
||
Hutt JA,
|
||
Wang G,
|
||
Benson J,
|
||
Crystal RG</span><br />
|
||
<span class="medgenPMjournal">Hum Gene Ther Clin Dev</span>
|
||
2013 Dec;24(4):161-73.
|
||
doi: 10.1089/humc.2013.168.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24191907" target="_blank">24191907</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22panacinar%20emphysema%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32800189">Alpha-1 Antitrypsin Deficiency Associated COPD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Strange C</span><br />
|
||
<span class="medgenPMjournal">Clin Chest Med</span>
|
||
2020 Sep;41(3):339-345.
|
||
doi: 10.1016/j.ccm.2020.05.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32800189" target="_blank">32800189</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10536068">Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Döring G</span><br />
|
||
<span class="medgenPMjournal">Pediatr Pulmonol</span>
|
||
1999 Nov;28(5):363-75.
|
||
doi: 10.1002/(sici)1099-0496(199911)28:5<363::aid-ppul9>3.0.co;2-#.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10536068" target="_blank">10536068</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8005246">Extent of centrilobular and panacinar emphysema in smokers' lungs: pathological and mechanical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saetta M,
|
||
Kim WD,
|
||
Izquierdo JL,
|
||
Ghezzo H,
|
||
Cosio MG</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
1994 Apr;7(4):664-71.
|
||
doi: 10.1183/09031936.94.07040664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8005246" target="_blank">8005246</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2117160">Discovery of alpha 1-antitrypsin deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eriksson S</span><br />
|
||
<span class="medgenPMjournal">Lung</span>
|
||
1990;168 Suppl:523-9.
|
||
doi: 10.1007/BF02718174.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2117160" target="_blank">2117160</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7388118">Biochemical and anatomical study of collagen and associated macromolecules in pulmonary panacinar emphysema and spontaneous pneumothorax.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Metivier H,
|
||
Masse R,
|
||
Vai F,
|
||
Pariente R</span><br />
|
||
<span class="medgenPMjournal">Biomedicine</span>
|
||
1980 May;32(2):81-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7388118" target="_blank">7388118</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Panacinar%20emphysema%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (30)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36965591">Small airways disease in patients with alpha-1 antitrypsin deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Toumpanakis D,
|
||
Usmani OS</span><br />
|
||
<span class="medgenPMjournal">Respir Med</span>
|
||
2023 May;211:107222.
|
||
Epub 2023 Mar 23
|
||
doi: 10.1016/j.rmed.2023.107222.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36965591" target="_blank">36965591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22498410">Swyer-James-MacLeod syndrome in a surgically treated child: a case report and brief literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">da Silva PS,
|
||
Lopes R,
|
||
Neto HM</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Surg</span>
|
||
2012 Apr;47(4):e17-22.
|
||
doi: 10.1016/j.jpedsurg.2011.12.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22498410" target="_blank">22498410</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12376606">Thoracic complications of illicit drug use: an organ system approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gotway MB,
|
||
Marder SR,
|
||
Hanks DK,
|
||
Leung JW,
|
||
Dawn SK,
|
||
Gean AD,
|
||
Reddy GP,
|
||
Araoz PA,
|
||
Webb WR</span><br />
|
||
<span class="medgenPMjournal">Radiographics</span>
|
||
2002 Oct;22 Spec No:S119-35.
|
||
doi: 10.1148/radiographics.22.suppl_1.g02oc01s119.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12376606" target="_blank">12376606</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10701626">Talcosis associated with IV abuse of oral medications: CT findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ward S,
|
||
Heyneman LE,
|
||
Reittner P,
|
||
Kazerooni EA,
|
||
Godwin JD,
|
||
Müller NL</span><br />
|
||
<span class="medgenPMjournal">AJR Am J Roentgenol</span>
|
||
2000 Mar;174(3):789-93.
|
||
doi: 10.2214/ajr.174.3.1740789.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10701626" target="_blank">10701626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9447774">Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Bull World Health Organ</span>
|
||
1997;75(5):397-415.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9447774" target="_blank">9447774</a><a href="/pmc/articles/PMC2487011" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Panacinar%20emphysema%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/24507836">Alpha1-antitrypsin review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stockley RA</span><br />
|
||
<span class="medgenPMjournal">Clin Chest Med</span>
|
||
2014 Mar;35(1):39-50.
|
||
Epub 2013 Dec 12
|
||
doi: 10.1016/j.ccm.2013.10.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24507836" target="_blank">24507836</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12376606">Thoracic complications of illicit drug use: an organ system approach.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gotway MB,
|
||
Marder SR,
|
||
Hanks DK,
|
||
Leung JW,
|
||
Dawn SK,
|
||
Gean AD,
|
||
Reddy GP,
|
||
Araoz PA,
|
||
Webb WR</span><br />
|
||
<span class="medgenPMjournal">Radiographics</span>
|
||
2002 Oct;22 Spec No:S119-35.
|
||
doi: 10.1148/radiographics.22.suppl_1.g02oc01s119.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12376606" target="_blank">12376606</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10536068">Serine proteinase inhibitor therapy in alpha(1)-antitrypsin inhibitor deficiency and cystic fibrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Döring G</span><br />
|
||
<span class="medgenPMjournal">Pediatr Pulmonol</span>
|
||
1999 Nov;28(5):363-75.
|
||
doi: 10.1002/(sici)1099-0496(199911)28:5<363::aid-ppul9>3.0.co;2-#.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10536068" target="_blank">10536068</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8005246">Extent of centrilobular and panacinar emphysema in smokers' lungs: pathological and mechanical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saetta M,
|
||
Kim WD,
|
||
Izquierdo JL,
|
||
Ghezzo H,
|
||
Cosio MG</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
1994 Apr;7(4):664-71.
|
||
doi: 10.1183/09031936.94.07040664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8005246" target="_blank">8005246</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3896239">Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Straus SD,
|
||
Fells GA,
|
||
Wewers MD,
|
||
Courtney M,
|
||
Tessier LH,
|
||
Tolstoshev P,
|
||
Lecocq JP,
|
||
Crystal RG</span><br />
|
||
<span class="medgenPMjournal">Biochem Biophys Res Commun</span>
|
||
1985 Aug 15;130(3):1177-84.
|
||
doi: 10.1016/0006-291x(85)91739-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3896239" target="_blank">3896239</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Panacinar%20emphysema%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (20)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16129256">High resolution computed tomographic features of pulmonary alveolar microlithiasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Deniz O,
|
||
Ors F,
|
||
Tozkoparan E,
|
||
Ozcan A,
|
||
Gumus S,
|
||
Bozlar U,
|
||
Bilgic H,
|
||
Ekiz K,
|
||
Demirci N</span><br />
|
||
<span class="medgenPMjournal">Eur J Radiol</span>
|
||
2005 Sep;55(3):452-60.
|
||
doi: 10.1016/j.ejrad.2005.01.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16129256" target="_blank">16129256</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15725045">Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abboud RT,
|
||
Ford GT,
|
||
Chapman KR</span><br />
|
||
<span class="medgenPMjournal">Treat Respir Med</span>
|
||
2005;4(1):1-8.
|
||
doi: 10.2165/00151829-200504010-00001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15725045" target="_blank">15725045</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15619203">The bronchopulmonary pathology of alpha-1 antitrypsin (AAT) deficiency: findings of the Death Review Committee of the national registry for individuals with Severe Deficiency of Alpha-1 Antitrypsin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomashefski JF Jr,
|
||
Crystal RG,
|
||
Wiedemann HP,
|
||
Mascha E,
|
||
Stoller JK;
|
||
Alpha 1-Antitrypsin Deficiency Registry Study Group</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2004 Dec;35(12):1452-61.
|
||
doi: 10.1016/j.humpath.2004.08.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15619203" target="_blank">15619203</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10554418">Subjective symptoms and prognosis after lung volume reduction surgery in patients with severe pulmonary emphysema.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sugi K,
|
||
Kaneda Y,
|
||
Esato K</span><br />
|
||
<span class="medgenPMjournal">Jpn J Thorac Cardiovasc Surg</span>
|
||
1999 Oct;47(10):489-94.
|
||
doi: 10.1007/BF03218048.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10554418" target="_blank">10554418</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9447774">Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Bull World Health Organ</span>
|
||
1997;75(5):397-415.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9447774" target="_blank">9447774</a><a href="/pmc/articles/PMC2487011" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Panacinar%20emphysema%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/15725045">Emphysema in alpha1-antitrypsin deficiency: does replacement therapy affect outcome?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abboud RT,
|
||
Ford GT,
|
||
Chapman KR</span><br />
|
||
<span class="medgenPMjournal">Treat Respir Med</span>
|
||
2005;4(1):1-8.
|
||
doi: 10.2165/00151829-200504010-00001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15725045" target="_blank">15725045</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8005246">Extent of centrilobular and panacinar emphysema in smokers' lungs: pathological and mechanical implications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saetta M,
|
||
Kim WD,
|
||
Izquierdo JL,
|
||
Ghezzo H,
|
||
Cosio MG</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
1994 Apr;7(4):664-71.
|
||
doi: 10.1183/09031936.94.07040664.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8005246" target="_blank">8005246</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8370825">Panacinar emphysema: CT and pathologic findings.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Spouge D,
|
||
Mayo JR,
|
||
Cardoso W,
|
||
Müller NL</span><br />
|
||
<span class="medgenPMjournal">J Comput Assist Tomogr</span>
|
||
1993 Sep-Oct;17(5):710-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8370825" target="_blank">8370825</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3896239">Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Straus SD,
|
||
Fells GA,
|
||
Wewers MD,
|
||
Courtney M,
|
||
Tessier LH,
|
||
Tolstoshev P,
|
||
Lecocq JP,
|
||
Crystal RG</span><br />
|
||
<span class="medgenPMjournal">Biochem Biophys Res Commun</span>
|
||
1985 Aug 15;130(3):1177-84.
|
||
doi: 10.1016/0006-291x(85)91739-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3896239" target="_blank">3896239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7388118">Biochemical and anatomical study of collagen and associated macromolecules in pulmonary panacinar emphysema and spontaneous pneumothorax.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Metivier H,
|
||
Masse R,
|
||
Vai F,
|
||
Pariente R</span><br />
|
||
<span class="medgenPMjournal">Biomedicine</span>
|
||
1980 May;32(2):81-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7388118" target="_blank">7388118</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Panacinar%20emphysema%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (17)</a></div></div>
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