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<meta name="keywords" content="C3554721, congenital abnormality, ectasic coloboma, morning glory anomaly, morning glory disc anomaly, morning glory disk anomaly, morning glory optic disc, morning glory syndrome, volubilis syndrome, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormality of the optic nerve in which the optic nerve is large and funneled and displays a conical excavation of the optic disc. The optic disc appears dysplastic." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Morning glory syndrome (Concept Id: C3554721)
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<!--
UID=767635
ConceptID=C3554721
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Morning glory syndrome</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767635</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3554721</a></dd><dt><span class="dotprefix"></span></dt><dd>Congenital Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>Morning glory anomaly</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0025514">HP:0025514</a></td></tr>
<tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0018169" target="_blank">MONDO:0018169</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/120430" target="_blank">120430</a>; <a href="https://omim.org/entry/607108" target="_blank">607108</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=35737">ORPHA35737</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An abnormality of the optic nerve in which the optic nerve is large and funneled and displays a conical excavation of the optic disc. The optic disc appears dysplastic. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009363[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=1046">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0009363[DISCUI]&amp;test_type=Research" ref="ncbi_uid=1046">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1046" target="_blank" href="/omim/606608">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=1046" ref="ncbi_uid=1046">V</a></span></span><span class="TLline"><a href="/medgen/1046" ref="tree=GTR&amp;ncbi_uid=1046&amp;link_uid=1046" title="View MedGen record for 'Congenital ocular coloboma'">Congenital ocular coloboma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0155299[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=57832">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0155299[DISCUI]&amp;test_type=Research&amp;redirect=true" ref="ncbi_uid=57832">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=57832" target="_blank" href="/omim/120430">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=57832" ref="ncbi_uid=57832">V</a></span></span><span class="TLline"><a href="/medgen/57832" ref="tree=GTR&amp;ncbi_uid=57832&amp;link_uid=57832" title="View MedGen record for 'Coloboma of optic nerve'">Coloboma of optic nerve</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=767635" target="_blank" href="/omim/120430">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Morning glory syndrome</span></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/1370071" ref="tree=MeSH" title="MedGen record for Abnormality of the eye">Abnormality of the eye</a></span><ul><li><span class="TLline"><a href="/medgen/868526" ref="tree=MeSH" title="MedGen record for Abnormal eye morphology">Abnormal eye morphology</a></span><ul><li><span class="TLline"><a href="/medgen/870893" ref="tree=MeSH" title="MedGen record for Abnormal posterior eye segment morphology">Abnormal posterior eye segment morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871316" ref="tree=MeSH" title="MedGen record for Abnormal fundus morphology">Abnormal fundus morphology</a></span><ul><li><span class="TLline"><a href="/medgen/472883" ref="tree=MeSH" title="MedGen record for Abnormal optic nerve morphology">Abnormal optic nerve morphology</a></span><ul><li><span class="matched_ds">Morning glory syndrome</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_322281"><div><strong>Isolated optic nerve hypoplasia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322281</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1833797</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A rare genetic optic nerve disorder characterized by visual impairment or blindness resulting from varying degrees of underdevelopment of the optic nerve or even complete absence of the optic nerve, ganglion cells, and central retinal vessels. It may be unilateral, typically with otherwise normal brain development, or bilateral with accompanying severe and widespread congenital malformations of the central nervous system.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/322281">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_339002"><div><strong>Renal coloboma syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339002</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information."><span class="highlight" style="background-color:">C1852759</span></a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">PAX2-related disorder is an autosomal dominant disorder associated with renal and eye abnormalities. The disorder was originally referred to as renal coloboma syndrome and characterized by renal hypodysplasia and abnormalities of the optic nerve; with improved access to molecular testing, a wider range of phenotypes has been recognized in association with pathogenic variants in PAX2. Abnormal renal structure or function is noted in 92% of affected individuals and ophthalmologic abnormalities in 77% of affected individuals. Renal abnormalities can be clinically silent in rare individuals. In most individuals, clinically significant renal insufficiency / renal failure is reported. End-stage renal disease requiring renal transplant is not uncommon. Uric acid nephrolithiasis has been reported. Ophthalmologic abnormalities are typically described as optic nerve coloboma or dysplasia. Iris colobomas have not been reported in any individual with PAX2related disorder. Ophthalmologic abnormalities may significantly impair vision in some individuals, while others have subtle changes only noted after detailed ophthalmologic examination. Additional clinical findings include high-frequency sensorineural hearing loss, soft skin, and ligamentous laxity. PAX2 pathogenic variants have been identified in multiple sporadic and familial cases of nonsyndromic renal disease including renal hypodysplasia and focal segmental glomerulosclerosis.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/339002">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_393758"><div><strong>Oculoauricular syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>393758</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2677500</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Oculoauricular syndrome (OCACS) is characterized by complex ocular anomalies, including congenital cataract, anterior segment dysgenesis, iris coloboma, and early-onset retinal dystrophy, and dysplastic ears with abnormal external ear cartilage (summary by Gillespie et al., 2015).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/393758">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_482396"><div><strong>Joubert syndrome 14</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482396</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3280766</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Classic Joubert syndrome (JS) is characterized by three primary findings: A distinctive cerebellar and brain stem malformation called the molar tooth sign (MTS). Hypotonia. Developmental delays. Often these findings are accompanied by episodic tachypnea or apnea and/or atypical eye movements. In general, the breathing abnormalities improve with age, truncal ataxia develops over time, and acquisition of gross motor milestones is delayed. Cognitive abilities are variable, ranging from severe intellectual disability to normal. Additional findings can include retinal dystrophy, renal disease, ocular colobomas, occipital encephalocele, hepatic fibrosis, polydactyly, oral hamartomas, and endocrine abnormalities. Both intra- and interfamilial variation are seen.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/482396">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_1859952"><div><strong>Coloboma, ocular, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1859952</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C5886785</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Coloboma is an ocular birth defect resulting from abnormal development of the eye during embryogenesis. It is defined as a congenital defect in any ocular tissue, typically presenting as absent tissue or a gap, at a site consistent with aberrant closure of the optic fissure. Failure of fusion can lead to coloboma of one or multiple regions of the inferior portion of the eye affecting any part of the globe traversed by the fissure, from the iris to the optic nerve, including the ciliary body, retina, and choroid. Coloboma is also frequently associated with small (microphthalmic) or absent (anophthalmic) eyes as part of an interrelated spectrum of developmental eye anomalies, and can affect either one or both eyes (summary by Kelberman et al., 2014).&#13; Microphthalmia/coloboma-12 (MCOPCB12) is characterized by inter- and intrafamilial variability. In addition to microphthalmia and coloboma, other ocular anomalies include iris hypoplasia, aphakia or small lens, lens subluxation, congenital cataract, microcornea, and sclerocornea. Some patients also exhibit neurodevelopmental anomalies (Deml et al., 2016; Williamson et al., 2020).&#13; For a discussion of genetic heterogeneity of colobomatous microphthalmia, see MCOPCB1 (300345).</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/1859952">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1859952" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Coloboma, ocular, autosomal dominant</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322281" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Isolated optic nerve hypoplasia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482396" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Joubert syndrome 14</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_393758" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oculoauricular syndrome</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339002" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Renal coloboma syndrome</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/24404661">Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Y,
Ou H,
Zhu T</span><br />
<span class="medgenPMjournal">Eye Sci</span>
2013 Mar;28(1):7-10.
<span class="bold">PMID: </span><a href="/pubmed/24404661" target="_blank">24404661</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23878133">Clinical characteristics and treatment of 22 eyes of morning glory syndrome associated with persistent hyperplastic primary vitreous.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fei P,
Zhang Q,
Li J,
Zhao P</span><br />
<span class="medgenPMjournal">Br J Ophthalmol</span>
2013 Oct;97(10):1262-7.
Epub 2013 Jul 22
doi: 10.1136/bjophthalmol-2013-303565.
<span class="bold">PMID: </span><a href="/pubmed/23878133" target="_blank">23878133</a><a href="/pmc/articles/PMC3786642" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22morning%20glory%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38236592">Intra-Anterior Chamber Injection of Ranibizumab in Advanced Pediatric Vitreoretinal Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang W,
Liu H,
Chen Y,
Zhang X,
Gu VY,
Xiao H,
Yang Y,
Yin J,
Peng J,
Zhao P</span><br />
<span class="medgenPMjournal">JAMA Ophthalmol</span>
2024 Feb 1;142(2):133-139.
doi: 10.1001/jamaophthalmol.2023.6198.
<span class="bold">PMID: </span><a href="/pubmed/38236592" target="_blank">38236592</a><a href="/pmc/articles/PMC10797525" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35446191">Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gündüz AK,
Mirzayev I,
Tetik D</span><br />
<span class="medgenPMjournal">J Pediatr Ophthalmol Strabismus</span>
2023 Jan-Feb;60(1):60-74.
Epub 2022 Apr 21
doi: 10.3928/01913913-20220228-01.
<span class="bold">PMID: </span><a href="/pubmed/35446191" target="_blank">35446191</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31931391">Current management of congenital anterior cranial base encephaloceles.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thompson HM,
Schlosser RJ,
McCarty Walsh E,
Cho DY,
Grayson JW,
Karnezis TT,
Miller PL,
Woodworth BA</span><br />
<span class="medgenPMjournal">Int J Pediatr Otorhinolaryngol</span>
2020 Apr;131:109868.
Epub 2020 Jan 8
doi: 10.1016/j.ijporl.2020.109868.
<span class="bold">PMID: </span><a href="/pubmed/31931391" target="_blank">31931391</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30222801">Peripheral Retinal Nonperfusion in Pediatric Patients With Morning Glory Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">She K,
Zhang Q,
Fei P,
Peng J,
Lyu J,
Li Y,
Huang Q,
Zhao P</span><br />
<span class="medgenPMjournal">Ophthalmic Surg Lasers Imaging Retina</span>
2018 Sep 1;49(9):674-679.
doi: 10.3928/23258160-20180831-04.
<span class="bold">PMID: </span><a href="/pubmed/30222801" target="_blank">30222801</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18388784">Neuronal migration disorders, agenesis of corpus callosum, preauricular skin tag and bilateral morning glory syndrome in a term newborn infant.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Görbe É,
Vámos R,
Rudas G,
Jeager J,
Harmath Á,
Csaba Á,
Csabay L</span><br />
<span class="medgenPMjournal">Clin Dysmorphol</span>
2008 Apr;17(2):123-125.
doi: 10.1097/MCD.0b013e32823ecf90.
<span class="bold">PMID: </span><a href="/pubmed/18388784" target="_blank">18388784</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morning%20glory%20syndrome%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (21)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37817347">Multimodal imaging of morning glory syndrome with persistent hyperplastic primary vitreous.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zheng S,
Cao JF,
Wang XY,
Wu B,
Wang ZJ,
Xiao B,
Duan JL,
Hu P</span><br />
<span class="medgenPMjournal">J Clin Ultrasound</span>
2023 Oct;51(8):1364-1365.
Epub 2023 Sep 13
doi: 10.1002/jcu.23562.
<span class="bold">PMID: </span><a href="/pubmed/37817347" target="_blank">37817347</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36795105">Morning Glory Syndrome With Bergmeister Papilla and Retinal Detachment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yu G,
Zhai Z,
Ge J</span><br />
<span class="medgenPMjournal">JAMA Ophthalmol</span>
2023 Feb 1;141(2):e225555.
Epub 2023 Feb 16
doi: 10.1001/jamaophthalmol.2022.5555.
<span class="bold">PMID: </span><a href="/pubmed/36795105" target="_blank">36795105</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35776267">A case of renal coloboma syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ammayappan SK,
Rajagopalan A,
Arunachalam J,
Prasath A,
Durai R</span><br />
<span class="medgenPMjournal">J Nephrol</span>
2023 Jan;36(1):233-235.
Epub 2022 Jul 1
doi: 10.1007/s40620-022-01383-0.
<span class="bold">PMID: </span><a href="/pubmed/35776267" target="_blank">35776267</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25993084">Patient with Morning Glory syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Martins TG,
Martins DG,
Costa AL</span><br />
<span class="medgenPMjournal">Einstein (Sao Paulo)</span>
2015 Jan-Mar;13(1):165-6.
Epub 2015 Mar 3
doi: 10.1590/S1679-45082015AI2902.
<span class="bold">PMID: </span><a href="/pubmed/25993084" target="_blank">25993084</a><a href="/pmc/articles/PMC4946824" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23134929">Morning glory syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hossain MM,
Akhanda AH,
Islam MF,
Akonjee AR,
Khan N,
Ali M</span><br />
<span class="medgenPMjournal">Mymensingh Med J</span>
2012 Oct;21(4):749-51.
<span class="bold">PMID: </span><a href="/pubmed/23134929" target="_blank">23134929</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morning%20glory%20syndrome%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (56)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38236592">Intra-Anterior Chamber Injection of Ranibizumab in Advanced Pediatric Vitreoretinal Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang W,
Liu H,
Chen Y,
Zhang X,
Gu VY,
Xiao H,
Yang Y,
Yin J,
Peng J,
Zhao P</span><br />
<span class="medgenPMjournal">JAMA Ophthalmol</span>
2024 Feb 1;142(2):133-139.
doi: 10.1001/jamaophthalmol.2023.6198.
<span class="bold">PMID: </span><a href="/pubmed/38236592" target="_blank">38236592</a><a href="/pmc/articles/PMC10797525" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29324624">INTRAVITREAL AFLIBERCEPT IN THE TREATMENT OF POLYPOIDAL CHOROIDAL VASCULOPATHY ASSOCIATED WITH MORNING GLORY SYNDROME.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Iovino C,
Fossarello M,
Peiretti E</span><br />
<span class="medgenPMjournal">Retin Cases Brief Rep</span>
2020 Summer;14(3):278-281.
doi: 10.1097/ICB.0000000000000698.
<span class="bold">PMID: </span><a href="/pubmed/29324624" target="_blank">29324624</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24404661">Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang Y,
Ou H,
Zhu T</span><br />
<span class="medgenPMjournal">Eye Sci</span>
2013 Mar;28(1):7-10.
<span class="bold">PMID: </span><a href="/pubmed/24404661" target="_blank">24404661</a></div>
<div class="nl"><a target="_blank" href="/pubmed/14738491">Morning glory syndrome associated with posterior pituitary ectopia and hypopituitarism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pierre-Filho Pde T,
Limeira-Soares PH,
Marcondes AM</span><br />
<span class="medgenPMjournal">Acta Ophthalmol Scand</span>
2004 Feb;82(1):89-92.
doi: 10.1111/j.1395-3907.2004.00214.x.
<span class="bold">PMID: </span><a href="/pubmed/14738491" target="_blank">14738491</a></div>
<div class="nl"><a target="_blank" href="/pubmed/12972780">Retinal detachment in morning glory syndrome treated by triamcinolone acetonide-assisted pars plana vitrectomy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Matsumoto H,
Enaida H,
Hisatomi T,
Ueno A,
Nakamura T,
Yamanaka I,
Sakamoto T,
Ishibashi T</span><br />
<span class="medgenPMjournal">Retina</span>
2003 Aug;23(4):569-72.
doi: 10.1097/00006982-200308000-00028.
<span class="bold">PMID: </span><a href="/pubmed/12972780" target="_blank">12972780</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morning%20glory%20syndrome%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/39463152">Human Amniotic Membrane: A Seal for Complex Retinal Detachments.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Özdemir Zeydanlı E,
Özdek Ş,
Yalçın E,
Özdemir HB</span><br />
<span class="medgenPMjournal">Turk J Ophthalmol</span>
2024 Oct 25;54(5):268-274.
doi: 10.4274/tjo.galenos.2024.56424.
<span class="bold">PMID: </span><a href="/pubmed/39463152" target="_blank">39463152</a><a href="/pmc/articles/PMC11589237" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37118812">Mediastinal high-grade vasculogenic mesenchymal tumour with seminoma: a case report and literature review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhanxian S,
Yuchen H,
Jinzhi W,
Lei Z</span><br />
<span class="medgenPMjournal">Diagn Pathol</span>
2023 Apr 28;18(1):56.
doi: 10.1186/s13000-023-01333-9.
<span class="bold">PMID: </span><a href="/pubmed/37118812" target="_blank">37118812</a><a href="/pmc/articles/PMC10142469" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28338555">RETINAL DETACHMENT AND RETROBULBAR CYSTS IN A LARGE COHORT OF OPTIC NERVE COLOBOMA.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chen YN,
Patel CK,
Kertes PJ,
Devenyi RG,
Blaser S,
Lam WC</span><br />
<span class="medgenPMjournal">Retina</span>
2018 Apr;38(4):692-697.
doi: 10.1097/IAE.0000000000001594.
<span class="bold">PMID: </span><a href="/pubmed/28338555" target="_blank">28338555</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10506908">Morning Glory syndrome. MR imaging.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Auber AE,
O'Hara M</span><br />
<span class="medgenPMjournal">Clin Imaging</span>
1999 May-Jun;23(3):152-8.
doi: 10.1016/s0899-7071(99)00118-7.
<span class="bold">PMID: </span><a href="/pubmed/10506908" target="_blank">10506908</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7573760">Basal encephaloceles with morning glory syndrome, and progressive hormonal and visual disturbances: case report and review of the literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Morioka M,
Marubayashi T,
Masumitsu T,
Miura M,
Ushio Y</span><br />
<span class="medgenPMjournal">Brain Dev</span>
1995 May-Jun;17(3):196-201.
doi: 10.1016/0387-7604(95)00021-3.
<span class="bold">PMID: </span><a href="/pubmed/7573760" target="_blank">7573760</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morning%20glory%20syndrome%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/38236592">Intra-Anterior Chamber Injection of Ranibizumab in Advanced Pediatric Vitreoretinal Diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang W,
Liu H,
Chen Y,
Zhang X,
Gu VY,
Xiao H,
Yang Y,
Yin J,
Peng J,
Zhao P</span><br />
<span class="medgenPMjournal">JAMA Ophthalmol</span>
2024 Feb 1;142(2):133-139.
doi: 10.1001/jamaophthalmol.2023.6198.
<span class="bold">PMID: </span><a href="/pubmed/38236592" target="_blank">38236592</a><a href="/pmc/articles/PMC10797525" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35446191">Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gündüz AK,
Mirzayev I,
Tetik D</span><br />
<span class="medgenPMjournal">J Pediatr Ophthalmol Strabismus</span>
2023 Jan-Feb;60(1):60-74.
Epub 2022 Apr 21
doi: 10.3928/01913913-20220228-01.
<span class="bold">PMID: </span><a href="/pubmed/35446191" target="_blank">35446191</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35263312">EVALUATION OF MORNING GLORY SYNDROME BY SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ohno-Matsui K,
Akiba M,
Ishibashi T,
Hirakata A</span><br />
<span class="medgenPMjournal">Retin Cases Brief Rep</span>
2023 Sep 1;17(5):542-547.
doi: 10.1097/ICB.0000000000001241.
<span class="bold">PMID: </span><a href="/pubmed/35263312" target="_blank">35263312</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31311513">Postoperative follow-up of a case of atypical morning glory syndrome associated with persistent fetal vasculature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang H,
Liang Y,
Long K,
Luo J</span><br />
<span class="medgenPMjournal">BMC Ophthalmol</span>
2019 Jul 16;19(1):150.
doi: 10.1186/s12886-019-1154-6.
<span class="bold">PMID: </span><a href="/pubmed/31311513" target="_blank">31311513</a><a href="/pmc/articles/PMC6636068" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/3932911">The 'morning glory' syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">De Laey JJ,
Ryckaert S,
Leys A</span><br />
<span class="medgenPMjournal">Ophthalmic Paediatr Genet</span>
1985 Feb;5(1-2):117-24.
doi: 10.3109/13816818509007865.
<span class="bold">PMID: </span><a href="/pubmed/3932911" target="_blank">3932911</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Morning%20glory%20syndrome%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=35737" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Morning%20glory%20syndrome" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22morning%20glory%20syndrome%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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