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<meta name="keywords" content="C3552553, chd7, chd7 hypogonadotropic hypogonadism, disease or syndrome, hh5, hypogonadotrophic hypogonadism 5 without anosmia, hypogonadotropic hypogonadism 5 with anosmia, hypogonadotropic hypogonadism 5 with or without anosmia, hypogonadotropic hypogonadism caused by mutation in chd7, kal5, kallmann syndrome 5, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=765467
|
||
ConceptID=C3552553
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-->
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<!--imgCountBooks = 4--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Images (4)</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image003.gif" src-large="/books/NBK1334/bin/kms-Image003.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F3/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image001.gif" src-large="/books/NBK1334/bin/kms-Image001.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F1/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image002.gif" src-large="/books/NBK1334/bin/kms-Image002.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F2/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image004.gif" src-large="/books/NBK1334/bin/kms-Image004.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F4/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Hypogonadotropic hypogonadism 5 with or without anosmia<span class="h1sub">(KAL5)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>765467</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3552553</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>HYPOGONADOTROPHIC HYPOGONADISM 5 WITHOUT ANOSMIA; HYPOGONADOTROPIC HYPOGONADISM 5 WITH ANOSMIA; KAL5; Kallmann syndrome 5</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CHD7 - ID: 55636 - NCBI Gene" href="/gene/55636" class="medgenPMinfo">CHD7</a> (8q12.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0012880" target="_blank">MONDO:0012880</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/612370" target="_blank">612370</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'
|
||
For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia, see 147950. <a target="_blank" href="http://www.omim.org/entry/612370">http://www.omim.org/entry/612370</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />In Kallmann syndrome, the sense of smell is either diminished (hyposmia) or completely absent (anosmia). This feature distinguishes Kallmann syndrome from most other forms of hypogonadotropic hypogonadism, which do not affect the sense of smell. Many people with Kallmann syndrome are not aware that they are unable to detect odors until the impairment is discovered through testing.<br /><br />Kallmann syndrome can have a wide variety of additional signs and symptoms. These include a failure of one kidney to develop (unilateral renal agenesis), abnormalities of bones in the fingers or toes, a cleft lip with or without an opening in the roof of the mouth (a cleft palate), abnormal eye movements, hearing loss, and abnormalities of tooth development. Some affected individuals have a feature called bimanual synkinesis, in which the movements of one hand are mirrored by the other hand. Bimanual synkinesis can make it difficult to do tasks that require the hands to move separately, such as playing a musical instrument.<br /><br />This disorder is a form of hypogonadotropic hypogonadism, which is a condition resulting from a lack of production of certain hormones that direct sexual development. These hormones are normally made in a part of the brain called the hypothalamus. Males born with hypogonadotropic hypogonadism often have an unusually small penis (micropenis) and undescended testes (cryptorchidism). At puberty, most affected individuals do not develop secondary sex characteristics, such as the growth of facial hair and deepening of the voice in males, the start of monthly periods (menstruation) and breast development in females, and a growth spurt in both sexes. Without treatment, most affected men and women are unable to have biological children (infertile).<br /><br />Kallmann syndrome is a condition characterized by delayed or absent puberty and an impaired sense of smell. <a target="_blank" href="https://medlineplus.gov/genetics/condition/kallmann-syndrome">https://medlineplus.gov/genetics/condition/kallmann-syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_8192"><div><strong>Cryptorchidism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010417</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cryptorchidism, or failure of testicular descent, is a common human congenital abnormality with a multifactorial etiology that likely reflects the involvement of endocrine, environmental, and hereditary factors. Cryptorchidism can result in infertility and increases risk for testicular tumors. Testicular descent from abdomen to scrotum occurs in 2 distinct phases: the transabdominal phase and the inguinoscrotal phase (summary by Gorlov et al., 2002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/8192">Feature record</a> | <a href="/medgen?term=%22Cryptorchidism%22%5BClinical%20Features%5D%20OR%208192%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_9164"><div><strong>Sensorineural hearing loss disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9164</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0018784</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9164">Feature record</a> | <a href="/medgen?term=%22Sensorineural%20hearing%20loss%20disorder%22%5BClinical%20Features%5D%20OR%209164%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1950"><div><strong>Anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1950</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003126</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1950">Feature record</a> | <a href="/medgen?term=%22Anosmia%22%5BClinical%20Features%5D%20OR%201950%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_756015"><div><strong>Cleft palate</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>756015</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2981150</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/756015">Feature record</a> | <a href="/medgen?term=%22Cleft%20palate%22%5BClinical%20Features%5D%20OR%20756015%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1370297"><div><strong>Cleft lip</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1370297</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4321245</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A gap in the lip or lips.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1370297">Feature record</a> | <a href="/medgen?term=%22Cleft%20lip%22%5BClinical%20Features%5D%20OR%201370297%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_82883"><div><strong>Hypogonadotropic hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82883</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271623</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82883">Feature record</a> | <a href="/medgen?term=%22Hypogonadotropic%20hypogonadism%22%5BClinical%20Features%5D%20OR%2082883%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1370297" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cleft lip</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_756015" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cleft palate</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82883" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_8192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cryptorchidism</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1950" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anosmia</a></span></li></ul></li><li><span class="TLline">Ear malformation</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9164" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Sensorineural hearing loss disorder</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0162809[DISCUI]&test_type=Clinical" ref="ncbi_uid=102469">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0162809[DISCUI]&test_type=Research" ref="ncbi_uid=102469">R</a></span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=102469" target="_blank" href="/omim/308700">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=102469">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=102469" ref="ncbi_uid=102469">V</a></span></span><span class="TLline"><a href="/medgen/102469" ref="tree=GTR&ncbi_uid=102469&link_uid=102469" title="View MedGen record for 'Hypogonadism with anosmia'">Hypogonadism with anosmia</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1563719[DISCUI]&test_type=Clinical" ref="ncbi_uid=295872">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=295872" target="_blank" href="/omim/308700">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=295872">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=295872" ref="ncbi_uid=295872">V</a></span></span><span class="TLline"><a href="/medgen/295872" ref="tree=GTR&ncbi_uid=295872&link_uid=295872" title="View MedGen record for 'Hypogonadotropic hypogonadism 1 with or without anosmia'">Hypogonadotropic hypogonadism 1 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1563720[DISCUI]&test_type=Clinical" ref="ncbi_uid=289648">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=289648" target="_blank" href="/omim/147950">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=289648">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=289648" ref="ncbi_uid=289648">V</a></span></span><span class="TLline"><a href="/medgen/289648" ref="tree=GTR&ncbi_uid=289648&link_uid=289648" title="View MedGen record for 'Hypogonadotropic hypogonadism 2 with or without anosmia'">Hypogonadotropic hypogonadism 2 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3550478[DISCUI]&test_type=Clinical" ref="ncbi_uid=763392">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=763392" target="_blank" href="/omim/244200">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=763392">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=763392" ref="ncbi_uid=763392">V</a></span></span><span class="TLline"><a href="/medgen/763392" ref="tree=GTR&ncbi_uid=763392&link_uid=763392" title="View MedGen record for 'Hypogonadotropic hypogonadism 3 with or without anosmia'">Hypogonadotropic hypogonadism 3 with or without anosmia</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552343[DISCUI]&test_type=Clinical" ref="ncbi_uid=765257">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765257" target="_blank" href="/omim/607002">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=765257">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765257" ref="ncbi_uid=765257">V</a></span></span><span class="TLline"><a href="/medgen/765257" ref="tree=GTR&ncbi_uid=765257&link_uid=765257" title="View MedGen record for 'Hypogonadotropic hypogonadism 4 with or without anosmia'">Hypogonadotropic hypogonadism 4 with or without anosmia</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552553[DISCUI]&test_type=Clinical" ref="ncbi_uid=765467">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765467" target="_blank" href="/omim/612370">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK1117%20OR%20NBK1334)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=765467">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765467" ref="ncbi_uid=765467">V</a></span></span><span class="TLline">Hypogonadotropic hypogonadism 5 with or without anosmia</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3552574[DISCUI]&test_type=Clinical" ref="ncbi_uid=765488">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=765488" target="_blank" href="/omim/600483">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1334/" ref="ncbi_uid=765488">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=765488" ref="ncbi_uid=765488">V</a></span></span><span class="TLline"><a href="/medgen/765488" ref="tree=GTR&ncbi_uid=765488&link_uid=765488" title="View MedGen record for 'Hypogonadotropic hypogonadism 6 with or without anosmia'">Hypogonadotropic hypogonadism 6 with or without anosmia</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/52948" ref="tree=MeSH" title="MedGen record for Abnormality of the genitourinary system">Abnormality of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/769757" ref="tree=MeSH" title="MedGen record for Congenital Reproductive System Abnormality">Congenital Reproductive System Abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/415936" ref="tree=MeSH" title="MedGen record for Disorder of sexual differentiation">Disorder of sexual differentiation</a></span><ul><li><span class="TLline"><a href="/medgen/414114" ref="tree=MeSH" title="MedGen record for 46,XY disorder of sex development">46,XY disorder of sex development</a></span><ul><li><span class="TLline"><a href="/medgen/102469" ref="tree=MeSH" title="MedGen record for Hypogonadism with anosmia">Hypogonadism with anosmia</a></span><ul><li><span class="matched_ds">Hypogonadotropic hypogonadism 5 with or without anosmia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38748847">Clinical practice guidelines for the care of girls and women with Turner syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gravholt CH,
|
||
Andersen NH,
|
||
Christin-Maitre S,
|
||
Davis SM,
|
||
Duijnhouwer A,
|
||
Gawlik A,
|
||
Maciel-Guerra AT,
|
||
Gutmark-Little I,
|
||
Fleischer K,
|
||
Hong D,
|
||
Klein KO,
|
||
Prakash SK,
|
||
Shankar RK,
|
||
Sandberg DE,
|
||
Sas TCJ,
|
||
Skakkebæk A,
|
||
Stochholm K,
|
||
van der Velden JA;
|
||
International Turner Syndrome Consensus Group,
|
||
Backeljauw PF</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jun 5;190(6):G53-G151.
|
||
doi: 10.1093/ejendo/lvae050.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38748847" target="_blank">38748847</a><a href="/pmc/articles/PMC11759048" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32576618">Parkinson's disease: etiopathogenesis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jankovic J,
|
||
Tan EK</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Aug;91(8):795-808.
|
||
Epub 2020 Jun 23
|
||
doi: 10.1136/jnnp-2019-322338.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32576618" target="_blank">32576618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29562364">Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bhasin S,
|
||
Brito JP,
|
||
Cunningham GR,
|
||
Hayes FJ,
|
||
Hodis HN,
|
||
Matsumoto AM,
|
||
Snyder PJ,
|
||
Swerdloff RS,
|
||
Wu FC,
|
||
Yialamas MA</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2018 May 1;103(5):1715-1744.
|
||
doi: 10.1210/jc.2018-00229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29562364" target="_blank">29562364</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (433)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38367592">APHRODITE criteria: addressing male patients with hypogonadism and/or infertility owing to altered idiopathic testicular function.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Esteves SC,
|
||
Humaidan P,
|
||
Ubaldi FM,
|
||
Alviggi C,
|
||
Antonio L,
|
||
Barratt CLR,
|
||
Behre HM,
|
||
Jørgensen N,
|
||
Pacey AA,
|
||
Simoni M,
|
||
Santi D</span><br />
|
||
<span class="medgenPMjournal">Reprod Biomed Online</span>
|
||
2024 Apr;48(4):103647.
|
||
Epub 2023 Oct 29
|
||
doi: 10.1016/j.rbmo.2023.103647.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38367592" target="_blank">38367592</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34864951">New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Federici S,
|
||
Goggi G,
|
||
Quinton R,
|
||
Giovanelli L,
|
||
Persani L,
|
||
Cangiano B,
|
||
Bonomi M</span><br />
|
||
<span class="medgenPMjournal">Endocr Rev</span>
|
||
2022 Sep 26;43(5):824-851.
|
||
doi: 10.1210/endrev/bnab043.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34864951" target="_blank">34864951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32026626">European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Corona G,
|
||
Goulis DG,
|
||
Huhtaniemi I,
|
||
Zitzmann M,
|
||
Toppari J,
|
||
Forti G,
|
||
Vanderschueren D,
|
||
Wu FC</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2020 Sep;8(5):970-987.
|
||
Epub 2020 Mar 20
|
||
doi: 10.1111/andr.12770.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32026626" target="_blank">32026626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31147553">Paediatric and adult-onset male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Rastrelli G,
|
||
Hackett G,
|
||
Seminara SB,
|
||
Huhtaniemi IT,
|
||
Rey RA,
|
||
Hellstrom WJG,
|
||
Palmert MR,
|
||
Corona G,
|
||
Dohle GR,
|
||
Khera M,
|
||
Chan YM,
|
||
Maggi M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2019 May 30;5(1):38.
|
||
doi: 10.1038/s41572-019-0087-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31147553" target="_blank">31147553</a><a href="/pmc/articles/PMC6944317" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3595)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38677870">Hypogonadotropic Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bangalore Krishna K,
|
||
Fuqua JS,
|
||
Witchel SF</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
|
||
2024 Jun;53(2):279-292.
|
||
Epub 2024 Feb 19
|
||
doi: 10.1016/j.ecl.2024.01.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38677870" target="_blank">38677870</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36341691">Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong Y,
|
||
Li Y,
|
||
Liu K,
|
||
Han X,
|
||
Liu R,
|
||
Ren Y,
|
||
Cong L,
|
||
Zhang Q,
|
||
Hou T,
|
||
Song L,
|
||
Tang S,
|
||
Shi L,
|
||
Luo Y,
|
||
Kalpouzos G,
|
||
Laukka EJ,
|
||
Winblad B,
|
||
Wang Y,
|
||
Du Y,
|
||
Qiu C</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Dement</span>
|
||
2023 Feb;19(2):589-601.
|
||
Epub 2022 Sep 15
|
||
doi: 10.1002/alz.12777.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36341691" target="_blank">36341691</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32026626">European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Corona G,
|
||
Goulis DG,
|
||
Huhtaniemi I,
|
||
Zitzmann M,
|
||
Toppari J,
|
||
Forti G,
|
||
Vanderschueren D,
|
||
Wu FC</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2020 Sep;8(5):970-987.
|
||
Epub 2020 Mar 20
|
||
doi: 10.1111/andr.12770.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32026626" target="_blank">32026626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31147553">Paediatric and adult-onset male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Rastrelli G,
|
||
Hackett G,
|
||
Seminara SB,
|
||
Huhtaniemi IT,
|
||
Rey RA,
|
||
Hellstrom WJG,
|
||
Palmert MR,
|
||
Corona G,
|
||
Dohle GR,
|
||
Khera M,
|
||
Chan YM,
|
||
Maggi M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2019 May 30;5(1):38.
|
||
doi: 10.1038/s41572-019-0087-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31147553" target="_blank">31147553</a><a href="/pmc/articles/PMC6944317" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24636400">Anabolic steroid-induced hypogonadism: diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rahnema CD,
|
||
Lipshultz LI,
|
||
Crosnoe LE,
|
||
Kovac JR,
|
||
Kim ED</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
2014 May;101(5):1271-9.
|
||
Epub 2014 Mar 14
|
||
doi: 10.1016/j.fertnstert.2014.02.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24636400" target="_blank">24636400</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3031)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37635965">The association of hypogonadism with depression and its treatments.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Indirli R,
|
||
Lanzi V,
|
||
Arosio M,
|
||
Mantovani G,
|
||
Ferrante E</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1198437.
|
||
Epub 2023 Aug 10
|
||
doi: 10.3389/fendo.2023.1198437.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37635965" target="_blank">37635965</a><a href="/pmc/articles/PMC10449581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34864951">New and Consolidated Therapeutic Options for Pubertal Induction in Hypogonadism: In-depth Review of the Literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Federici S,
|
||
Goggi G,
|
||
Quinton R,
|
||
Giovanelli L,
|
||
Persani L,
|
||
Cangiano B,
|
||
Bonomi M</span><br />
|
||
<span class="medgenPMjournal">Endocr Rev</span>
|
||
2022 Sep 26;43(5):824-851.
|
||
doi: 10.1210/endrev/bnab043.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34864951" target="_blank">34864951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32026626">European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males: Endorsing organization: European Society of Endocrinology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Corona G,
|
||
Goulis DG,
|
||
Huhtaniemi I,
|
||
Zitzmann M,
|
||
Toppari J,
|
||
Forti G,
|
||
Vanderschueren D,
|
||
Wu FC</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2020 Sep;8(5):970-987.
|
||
Epub 2020 Mar 20
|
||
doi: 10.1111/andr.12770.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32026626" target="_blank">32026626</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24636400">Anabolic steroid-induced hypogonadism: diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rahnema CD,
|
||
Lipshultz LI,
|
||
Crosnoe LE,
|
||
Kovac JR,
|
||
Kim ED</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
2014 May;101(5):1271-9.
|
||
Epub 2014 Mar 14
|
||
doi: 10.1016/j.fertnstert.2014.02.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24636400" target="_blank">24636400</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2319)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35874953">Revealing the mystery of persistent smell loss in Long COVID patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park JW,
|
||
Wang X,
|
||
Xu RH</span><br />
|
||
<span class="medgenPMjournal">Int J Biol Sci</span>
|
||
2022;18(12):4795-4808.
|
||
Epub 2022 Jul 15
|
||
doi: 10.7150/ijbs.73485.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35874953" target="_blank">35874953</a><a href="/pmc/articles/PMC9305264" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31216250">Long-Term Safety and Efficacy of Clomiphene Citrate for the Treatment of Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Krzastek SC,
|
||
Sharma D,
|
||
Abdullah N,
|
||
Sultan M,
|
||
Machen GL,
|
||
Wenzel JL,
|
||
Ells A,
|
||
Chen X,
|
||
Kavoussi M,
|
||
Costabile RA,
|
||
Smith RP,
|
||
Kavoussi PK</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
2019 Nov;202(5):1029-1035.
|
||
Epub 2019 Oct 9
|
||
doi: 10.1097/JU.0000000000000396.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31216250" target="_blank">31216250</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24709968">The hidden world of self-castration and testicular self-injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johnson TW,
|
||
Irwig MS</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Urol</span>
|
||
2014 May;11(5):297-300.
|
||
Epub 2014 Apr 8
|
||
doi: 10.1038/nrurol.2014.84.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24709968" target="_blank">24709968</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23643382">Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miraoui H,
|
||
Dwyer AA,
|
||
Sykiotis GP,
|
||
Plummer L,
|
||
Chung W,
|
||
Feng B,
|
||
Beenken A,
|
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Clarke J,
|
||
Pers TH,
|
||
Dworzynski P,
|
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Keefe K,
|
||
Niedziela M,
|
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Raivio T,
|
||
Crowley WF Jr,
|
||
Seminara SB,
|
||
Quinton R,
|
||
Hughes VA,
|
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Kumanov P,
|
||
Young J,
|
||
Yialamas MA,
|
||
Hall JE,
|
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Van Vliet G,
|
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Chanoine JP,
|
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Rubenstein J,
|
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Mohammadi M,
|
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Tsai PS,
|
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Sidis Y,
|
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Lage K,
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Pitteloud N</span><br />
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<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
2013 May 2;92(5):725-43.
|
||
doi: 10.1016/j.ajhg.2013.04.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23643382" target="_blank">23643382</a><a href="/pmc/articles/PMC3644636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17117301">Osteoporosis in men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Binkley N</span><br />
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<span class="medgenPMjournal">Arq Bras Endocrinol Metabol</span>
|
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2006 Aug;50(4):764-74.
|
||
doi: 10.1590/s0004-27302006000400021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17117301" target="_blank">17117301</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1564)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37486228">Longitudinal Association of COVID-19 Hospitalization and Death with Online Search for Loss of Smell or Taste.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Toomre D,
|
||
Kandula S,
|
||
Shaman J</span><br />
|
||
<span class="medgenPMjournal">Emerg Infect Dis</span>
|
||
2023 Aug;29(8):1711-1713.
|
||
doi: 10.3201/eid2908.230071.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37486228" target="_blank">37486228</a><a href="/pmc/articles/PMC10370832" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
|
||
Jang SS,
|
||
Lin HC,
|
||
Ma Y,
|
||
Khanwalkar AR,
|
||
Thai A,
|
||
Patel ZM</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Jun;13(6):989-997.
|
||
Epub 2022 Dec 21
|
||
doi: 10.1002/alr.23116.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36507615" target="_blank">36507615</a><a href="/pmc/articles/PMC9877663" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35075664">The occurrence of hypogonadotropic hypogonadism in Chinese men with type 2 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
||
Tian R,
|
||
Wang X,
|
||
Sun J,
|
||
Zhu L,
|
||
An X</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Jun;96(6):837-846.
|
||
Epub 2022 Jan 29
|
||
doi: 10.1111/cen.14680.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35075664" target="_blank">35075664</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23643382">Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miraoui H,
|
||
Dwyer AA,
|
||
Sykiotis GP,
|
||
Plummer L,
|
||
Chung W,
|
||
Feng B,
|
||
Beenken A,
|
||
Clarke J,
|
||
Pers TH,
|
||
Dworzynski P,
|
||
Keefe K,
|
||
Niedziela M,
|
||
Raivio T,
|
||
Crowley WF Jr,
|
||
Seminara SB,
|
||
Quinton R,
|
||
Hughes VA,
|
||
Kumanov P,
|
||
Young J,
|
||
Yialamas MA,
|
||
Hall JE,
|
||
Van Vliet G,
|
||
Chanoine JP,
|
||
Rubenstein J,
|
||
Mohammadi M,
|
||
Tsai PS,
|
||
Sidis Y,
|
||
Lage K,
|
||
Pitteloud N</span><br />
|
||
<span class="medgenPMjournal">Am J Hum Genet</span>
|
||
2013 May 2;92(5):725-43.
|
||
doi: 10.1016/j.ajhg.2013.04.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23643382" target="_blank">23643382</a><a href="/pmc/articles/PMC3644636" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9506244">Transdermal testosterone.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McClellan KJ,
|
||
Goa KL</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
1998 Feb;55(2):253-8; discussion 259.
|
||
doi: 10.2165/00003495-199855020-00006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9506244" target="_blank">9506244</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2666)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37697053">Do "testosterone boosters" really increase serum total testosterone? A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morgado A,
|
||
Tsampoukas G,
|
||
Sokolakis I,
|
||
Schoentgen N,
|
||
Urkmez A,
|
||
Sarikaya S</span><br />
|
||
<span class="medgenPMjournal">Int J Impot Res</span>
|
||
2024 Jun;36(4):348-364.
|
||
Epub 2023 Sep 11
|
||
doi: 10.1038/s41443-023-00763-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37697053" target="_blank">37697053</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35790713">Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lu Z,
|
||
Sun Y,
|
||
Zhang Y,
|
||
Chen Y,
|
||
Guo L,
|
||
Liao Y,
|
||
Kang Z,
|
||
Feng X,
|
||
Yue W</span><br />
|
||
<span class="medgenPMjournal">Transl Psychiatry</span>
|
||
2022 Jul 5;12(1):267.
|
||
doi: 10.1038/s41398-022-02027-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35790713" target="_blank">35790713</a><a href="/pmc/articles/PMC9256633" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35739136">Long-COVID in children and adolescents: a systematic review and meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Leon S,
|
||
Wegman-Ostrosky T,
|
||
Ayuzo Del Valle NC,
|
||
Perelman C,
|
||
Sepulveda R,
|
||
Rebolledo PA,
|
||
Cuapio A,
|
||
Villapol S</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Jun 23;12(1):9950.
|
||
doi: 10.1038/s41598-022-13495-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35739136" target="_blank">35739136</a><a href="/pmc/articles/PMC9226045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34463956">Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malik P,
|
||
Patel K,
|
||
Pinto C,
|
||
Jaiswal R,
|
||
Tirupathi R,
|
||
Pillai S,
|
||
Patel U</span><br />
|
||
<span class="medgenPMjournal">J Med Virol</span>
|
||
2022 Jan;94(1):253-262.
|
||
Epub 2021 Sep 7
|
||
doi: 10.1002/jmv.27309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34463956" target="_blank">34463956</a><a href="/pmc/articles/PMC8662132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (180)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3552553%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (69)</a></li>
|
||
<li><a href="/gtr/tests?term=C3552553%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C3552553%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (74)</a></li>
|
||
<li><a href="/gtr/tests?term=C3552553%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (23)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3552553%5bDISCUI%5d" target="_blank">See all (88)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=612370" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=608892" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=55636[geneid]" target="_blank">View CHD7 variations in ClinVar</a></li><li><a href="/nuccore/158081724" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=612370" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Kallmann+syndrome+5/8704" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/hypogonadotropic_hypogonadism_5_with_or_without_anosmia" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/kallmann-syndrome" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/10773/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/20301509" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=4" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/20301296" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=4" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=4" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Hypogonadotropic%20hypogonadism%205%20with%20or%20without%20anosmia%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=4&linkpostotal=4" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=765467" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=765467" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3552553[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C3552553[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=765467" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=765467" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=765467" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=765467" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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