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<!--
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UID=760252
|
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ConceptID=C0151539
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Increased blood urea nitrogen</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>760252</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151539</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Increased blood urea nitrogen (BUN); Increased BUN</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0003138">HP:0003138</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An increased amount of nitrogen in the form of urea in the blood. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Increased blood urea nitrogen</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/233128" ref="tree=MeSH" title="MedGen record for Abnormal Blood Chemistry and Hematology Test Result">Abnormal Blood Chemistry and Hematology Test Result</a></span><ul><li><span class="matched_ds">Increased blood urea nitrogen</span></li></ul></li></ul></div></div></div></div>
|
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_41678"><div><strong>Familial dysautonomia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41678</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0013364</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial dysautonomia, which affects the development and survival of sensory, sympathetic, and parasympathetic neurons, is a debilitating disorder present from birth. Neuronal degeneration progresses throughout life. Affected individuals have gastrointestinal dysfunction, autonomic crises (i.e., hypertensive vomiting attacks), recurrent pneumonia, altered pain sensitivity, altered temperature perception, and blood pressure instability. Hypotonia contributes to delay in acquisition of motor milestones. Optic neuropathy results in progressive vision loss. Older individuals often have a broad-based and ataxic gait that deteriorates over time. Developmental delay / intellectual disability occur in about 21% of individuals. Life expectancy is decreased.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41678">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_140788"><div><strong>Anti-glomerular basement membrane disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140788</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0403529</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Goodpasture syndrome, also known as anti-GBM disease, is a rare autoimmune disease consisting of alveolar hemorrhage and glomerulonephritis secondary to circulating antiglomerular basement membrane (anti-GBM) antibodies. Anti-GBM antibodies are directed against an antigen intrinsic to the alpha-3 chain of type IV collagen (COL4A3; 120070) that is expressed in the GBMs of the glomerular capillary loops and the basal membrane of the pulmonary alveoli. Goodpasture syndrome is suspected in patients with hemoptysis and hematuria and is confirmed by the presence of anti-GBM antibodies in renal biopsy specimens and serum. Patients with human leukocyte antigen HLA-DR15 and HLA-DR4 are susceptible to the development of Goodpasture syndrome. Reported cases of familial Goodpasture syndrome are extremely rare (summary by Angioi et al., 2017).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140788">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_224783"><div><strong>Upshaw-Schulman syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>224783</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1268935</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome (USS), is a rare autosomal recessive thrombotic microangiopathy (TMA). Clinically, acute phases of TTP are defined by microangiopathic mechanical hemolytic anemia, severe thrombocytopenia, and visceral ischemia. Hereditary TTP makes up 5% of TTP cases and is caused mostly by biallelic mutation in the ADAMTS13 gene, or in very rare cases, by monoallelic ADAMTS13 mutation associated with a cluster of single-nucleotide polymorphisms (SNPs); most cases of all TTP (95%) are acquired via an autoimmune mechanism (see 188030). Hereditary TTP is more frequent among child-onset TTP compared with adult-onset TTP, and its clinical presentation is significantly different as a function of its age of onset. Child-onset TTP usually starts in the neonatal period with hematological features and severe jaundice. In contrast, almost all cases of adult-onset hereditary TTP are unmasked during the first pregnancy of a woman whose disease was silent during childhood (summary by Joly et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/224783">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_412743"><div><strong>Hemolytic uremic syndrome, atypical, susceptibility to, 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>412743</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2749604</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/412743">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_414541"><div><strong>Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414541</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752036</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/414541">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_442875"><div><strong>Atypical hemolytic-uremic syndrome with C3 anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>442875</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752037</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/442875">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_416691"><div><strong>Atypical hemolytic-uremic syndrome with B factor anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416691</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752038</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/416691">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_414542"><div><strong>Atypical hemolytic-uremic syndrome with I factor anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414542</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752039</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/414542">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_414167"><div><strong>Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414167</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752040</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hemolytic-uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. The onset of atypical HUS (aHUS) ranges from the neonatal period to adulthood. Genetic aHUS accounts for an estimated 60% of all aHUS. Individuals with genetic aHUS frequently experience relapse even after complete recovery following the presenting episode; 60% of genetic aHUS progresses to end-stage renal disease (ESRD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/414167">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_416704"><div><strong>46,XY sex reversal 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>416704</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2752149</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sex reversal in an individual associated with a 9p24.3 deletion.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/416704">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462559"><div><strong>Hyperuricemia, pulmonary hypertension, renal failure, alkalosis syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462559</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151209</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">HUPRA syndrome is a severe autosomal recessive multisystem disorder characterized by onset in infancy of progressive renal failure leading to electrolyte imbalances, metabolic alkalosis, pulmonary hypertension, hypotonia, and delayed development. Affected individuals are born prematurely (summary by Belostotsky et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462559">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766688"><div><strong>Karyomegalic interstitial nephritis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766688</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3553774</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Karyomegalic tubulointerstitial nephritis (KMIN) is a rare kidney disease characterized clinically by onset in the third decade of progressive renal failure. Renal biopsy shows chronic tubulointerstitial nephritis and interstitial fibrosis associated with enlarged and atypical tubular epithelial cell nuclei (summary by Baba et al., 2006).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766688">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934708"><div><strong>Hyperuricemic nephropathy, familial juvenile type 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934708</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310741</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant tubulointerstitial kidney disease-5 (ADTKD5) is characterized by the onset of progressive chronic renal disease in the first decades of life. Mild hyperuricemia may be present, but gout, hypertension, and proteinuria are usually absent. The disease may be associated with anemia or neutropenia. Some patients may have additional findings, including poor overall growth and impaired cognitive function. Renal biopsy shows tubulointerstitial abnormalities with atrophic tubules and fibrosis; secondary glomerular abnormalities and simple cysts may also be present (summary by Bolar et al., 2016). For a discussion of genetic heterogeneity and revised nomenclature of ADTKD, see ADTKD1 (162000).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934708">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1645893"><div><strong>Familial juvenile hyperuricemic nephropathy type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1645893</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551496</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant tubulointerstitial kidney disease – UMOD (ADTKD-UMOD) is characterized by normal urinalysis and slowly progressive chronic kidney disease (CKD), usually first noted in the teen years and progressing to end-stage renal disease (ESRD) between the third and seventh decades. Hyperuricemia is often present from an early age, and gout (resulting from reduced kidney excretion of uric acid) occurs in the teenage years in about 8% of affected individuals and develops in 55% of affected individuals over time.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1645893">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1631307"><div><strong>Combined oxidative phosphorylation deficiency 34</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1631307</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693450</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">COXPD34 is an autosomal recessive disorder resulting from a defect in mitochondrial function. The phenotype is variable, but may include congenital sensorineural deafness, increased serum lactate, and hepatic and renal dysfunction. Neurologic function is relatively preserved (summary by Menezes et al., 2015). For a discussion of genetic heterogeneity of combined oxidative phosphorylation deficiency, see COXPD1 (609060).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1631307">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648402"><div><strong>Orthostatic hypotension 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648402</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4746777</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Dopamine beta-hydroxylase (DBH) deficiency is characterized by lack of sympathetic noradrenergic function resulting in profound deficits in autonomic regulation of cardiovascular function (orthostatic hypotension) and other autonomic dysfunction (ptosis, nasal stuffiness, sleep difficulties, and impaired ejaculation in males). Although DBH deficiency is present from birth, the diagnosis is often not generally recognized until late childhood. In the perinatal period, DBH deficiency has been complicated by vomiting, dehydration, hypotension, hypothermia, and hypoglycemia requiring repeated hospitalization, and the diagnosis may be identified fortuitously in the neonatal period with investigation of hypoglycemia. Children may report reduced exercise capacity. By early adulthood, individuals have profound orthostatic hypotension, greatly reduced exercise tolerance, ptosis, and nasal stuffiness. Presyncopal symptoms include dizziness, blurred vision, dyspnea, nuchal discomfort, and chest pain; symptoms may worsen in hot environments or after heavy meals or alcohol ingestion. Some individuals have abnormal kidney function, joint laxity, hypotonia, high-arched palate, anemia, and/or hypoglycemia.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648402">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1824010"><div><strong>Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824010</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774237</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation-2 (HUMOP2) is characterized by failure to thrive apparent in infancy despite adequate caloric intake. Affected individuals show normal thyroid function, hyperphagia, tachypnea, increased basal temperature, and increased sweating. Biochemical studies demonstrate increased mitochondrial oxygen consumption with inefficient production of ATP in the final steps of oxidative phosphorylation due to an uncoupling defect (Ganetzky et al., 2022). Genetic Heterogeneity of Hypermetabolism due to Uncoupled Mitochondrial Oxidative Phosphorylation See also HUMOP1 (238800).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1824010">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416704" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">46,XY sex reversal 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_140788" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anti-glomerular basement membrane disease</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_416691" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with B factor anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_442875" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with C3 anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414542" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with I factor anomaly</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (17)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414167" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with MCP/CD46 anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_414541" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atypical hemolytic-uremic syndrome with thrombomodulin anomaly</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1631307" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Combined oxidative phosphorylation deficiency 34</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_41678" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial dysautonomia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1645893" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial juvenile hyperuricemic nephropathy type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_412743" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hemolytic uremic syndrome, atypical, susceptibility to, 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1824010" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypermetabolism due to uncoupled mitochondrial oxidative phosphorylation 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462559" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperuricemia, pulmonary hypertension, renal failure, alkalosis syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934708" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyperuricemic nephropathy, familial juvenile type 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766688" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Karyomegalic interstitial nephritis</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648402" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orthostatic hypotension 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_224783" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Upshaw-Schulman syndrome</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33785837">Sensors for the detection of ammonia as a potential biomarker for health screening.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ricci PP,
|
||
Gregory OJ</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2021 Mar 30;11(1):7185.
|
||
doi: 10.1038/s41598-021-86686-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33785837" target="_blank">33785837</a><a href="/pmc/articles/PMC8009942" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22229644">Treatment of periodontal diseases reduces chronic systemic inflammation in maintenance hemodialysis patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siribamrungwong M,
|
||
Puangpanngam K</span><br />
|
||
<span class="medgenPMjournal">Ren Fail</span>
|
||
2012;34(2):171-5.
|
||
Epub 2012 Jan 9
|
||
doi: 10.3109/0886022X.2011.643351.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22229644" target="_blank">22229644</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21536855">Comparative effects of nesiritide and nitroglycerin on renal function, and incidence of renal injury by traditional and RIFLE criteria in acute heart failure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ng TM,
|
||
Ackerbauer KA,
|
||
Hyderi AF,
|
||
Hshieh S,
|
||
Elkayam U</span><br />
|
||
<span class="medgenPMjournal">J Cardiovasc Pharmacol Ther</span>
|
||
2012 Mar;17(1):79-85.
|
||
Epub 2011 May 2
|
||
doi: 10.1177/1074248411406441.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21536855" target="_blank">21536855</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22increased%20blood%20urea%20nitrogen%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38521120">Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yarrarapu SNS,
|
||
Goyal A,
|
||
Venkata VS,
|
||
Panchal V,
|
||
Sivasubramanian BP,
|
||
Du DT,
|
||
Jakulla RS,
|
||
Pamulapati H,
|
||
Afaq MA,
|
||
Owens S,
|
||
Dalia T</span><br />
|
||
<span class="medgenPMjournal">J Cardiol</span>
|
||
2024 Jul;84(1):22-29.
|
||
Epub 2024 Mar 22
|
||
doi: 10.1016/j.jjcc.2024.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38521120" target="_blank">38521120</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35458440">Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kameda T,
|
||
Shide K,
|
||
Tahira Y,
|
||
Sekine M,
|
||
Sato S,
|
||
Ishizaki J,
|
||
Takeuchi M,
|
||
Akizuki K,
|
||
Kamiunten A,
|
||
Shimoda H,
|
||
Toyama T,
|
||
Maeda K,
|
||
Yamashita K,
|
||
Kawano N,
|
||
Kawano H,
|
||
Hidaka T,
|
||
Yamaguchi H,
|
||
Kubuki Y,
|
||
Kitanaka A,
|
||
Matsuoka H,
|
||
Shimoda K</span><br />
|
||
<span class="medgenPMjournal">Viruses</span>
|
||
2022 Mar 29;14(4)
|
||
doi: 10.3390/v14040710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35458440" target="_blank">35458440</a><a href="/pmc/articles/PMC9030133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35362765">Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ohbe H,
|
||
Goto T,
|
||
Nakamura K,
|
||
Matsui H,
|
||
Yasunaga H</span><br />
|
||
<span class="medgenPMjournal">Intensive Care Med</span>
|
||
2022 Jun;48(6):679-689.
|
||
Epub 2022 Apr 1
|
||
doi: 10.1007/s00134-022-06688-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35362765" target="_blank">35362765</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34922334">Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaergaard AD,
|
||
Teumer A,
|
||
Witte DR,
|
||
Stanzick KJ,
|
||
Winkler TW,
|
||
Burgess S,
|
||
Ellervik C</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2022 Mar 4;68(3):461-472.
|
||
doi: 10.1093/clinchem/hvab249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34922334" target="_blank">34922334</a><a href="/pmc/articles/PMC7614591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34452584">Hyperglycemia exacerbates cadmium-induced glomerular nephrosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li M,
|
||
Liu X,
|
||
Zhang Z</span><br />
|
||
<span class="medgenPMjournal">Toxicol Ind Health</span>
|
||
2021 Sep;37(9):555-563.
|
||
Epub 2021 Aug 27
|
||
doi: 10.1177/07482337211037880.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34452584" target="_blank">34452584</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20blood%20urea%20nitrogen%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38521120">Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yarrarapu SNS,
|
||
Goyal A,
|
||
Venkata VS,
|
||
Panchal V,
|
||
Sivasubramanian BP,
|
||
Du DT,
|
||
Jakulla RS,
|
||
Pamulapati H,
|
||
Afaq MA,
|
||
Owens S,
|
||
Dalia T</span><br />
|
||
<span class="medgenPMjournal">J Cardiol</span>
|
||
2024 Jul;84(1):22-29.
|
||
Epub 2024 Mar 22
|
||
doi: 10.1016/j.jjcc.2024.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38521120" target="_blank">38521120</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36364721">Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fu S,
|
||
Zhang L,
|
||
Ma F,
|
||
Xue S,
|
||
Sun T,
|
||
Xu Z</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2022 Oct 23;14(21)
|
||
doi: 10.3390/nu14214458.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36364721" target="_blank">36364721</a><a href="/pmc/articles/PMC9654848" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35458440">Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kameda T,
|
||
Shide K,
|
||
Tahira Y,
|
||
Sekine M,
|
||
Sato S,
|
||
Ishizaki J,
|
||
Takeuchi M,
|
||
Akizuki K,
|
||
Kamiunten A,
|
||
Shimoda H,
|
||
Toyama T,
|
||
Maeda K,
|
||
Yamashita K,
|
||
Kawano N,
|
||
Kawano H,
|
||
Hidaka T,
|
||
Yamaguchi H,
|
||
Kubuki Y,
|
||
Kitanaka A,
|
||
Matsuoka H,
|
||
Shimoda K</span><br />
|
||
<span class="medgenPMjournal">Viruses</span>
|
||
2022 Mar 29;14(4)
|
||
doi: 10.3390/v14040710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35458440" target="_blank">35458440</a><a href="/pmc/articles/PMC9030133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34922334">Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaergaard AD,
|
||
Teumer A,
|
||
Witte DR,
|
||
Stanzick KJ,
|
||
Winkler TW,
|
||
Burgess S,
|
||
Ellervik C</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2022 Mar 4;68(3):461-472.
|
||
doi: 10.1093/clinchem/hvab249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34922334" target="_blank">34922334</a><a href="/pmc/articles/PMC7614591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33465709">Predictive performance of blood urea nitrogen to serum albumin ratio in elderly patients with gastrointestinal bleeding.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bae SJ,
|
||
Kim K,
|
||
Yun SJ,
|
||
Lee SH</span><br />
|
||
<span class="medgenPMjournal">Am J Emerg Med</span>
|
||
2021 Mar;41:152-157.
|
||
Epub 2020 Dec 23
|
||
doi: 10.1016/j.ajem.2020.12.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33465709" target="_blank">33465709</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20blood%20urea%20nitrogen%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (26)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38521120">Comprehensive review of statin-intolerance and the practical application of Bempedoic Acid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yarrarapu SNS,
|
||
Goyal A,
|
||
Venkata VS,
|
||
Panchal V,
|
||
Sivasubramanian BP,
|
||
Du DT,
|
||
Jakulla RS,
|
||
Pamulapati H,
|
||
Afaq MA,
|
||
Owens S,
|
||
Dalia T</span><br />
|
||
<span class="medgenPMjournal">J Cardiol</span>
|
||
2024 Jul;84(1):22-29.
|
||
Epub 2024 Mar 22
|
||
doi: 10.1016/j.jjcc.2024.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38521120" target="_blank">38521120</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35767918">Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim DH,
|
||
Choi HI,
|
||
Park JS,
|
||
Kim CS,
|
||
Bae EH,
|
||
Ma SK,
|
||
Kim SW</span><br />
|
||
<span class="medgenPMjournal">Redox Biol</span>
|
||
2022 Aug;54:102382.
|
||
Epub 2022 Jun 23
|
||
doi: 10.1016/j.redox.2022.102382.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35767918" target="_blank">35767918</a><a href="/pmc/articles/PMC9241134" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35362765">Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ohbe H,
|
||
Goto T,
|
||
Nakamura K,
|
||
Matsui H,
|
||
Yasunaga H</span><br />
|
||
<span class="medgenPMjournal">Intensive Care Med</span>
|
||
2022 Jun;48(6):679-689.
|
||
Epub 2022 Apr 1
|
||
doi: 10.1007/s00134-022-06688-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35362765" target="_blank">35362765</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34922334">Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaergaard AD,
|
||
Teumer A,
|
||
Witte DR,
|
||
Stanzick KJ,
|
||
Winkler TW,
|
||
Burgess S,
|
||
Ellervik C</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2022 Mar 4;68(3):461-472.
|
||
doi: 10.1093/clinchem/hvab249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34922334" target="_blank">34922334</a><a href="/pmc/articles/PMC7614591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28674911">The Basic Metabolic Profile in Heart Failure-Marker and Modifier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elfar A,
|
||
Sambandam KK</span><br />
|
||
<span class="medgenPMjournal">Curr Heart Fail Rep</span>
|
||
2017 Aug;14(4):311-320.
|
||
doi: 10.1007/s11897-017-0344-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28674911" target="_blank">28674911</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20blood%20urea%20nitrogen%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (45)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35458440">Prognosis of Indolent Adult T-Cell Leukemia/Lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kameda T,
|
||
Shide K,
|
||
Tahira Y,
|
||
Sekine M,
|
||
Sato S,
|
||
Ishizaki J,
|
||
Takeuchi M,
|
||
Akizuki K,
|
||
Kamiunten A,
|
||
Shimoda H,
|
||
Toyama T,
|
||
Maeda K,
|
||
Yamashita K,
|
||
Kawano N,
|
||
Kawano H,
|
||
Hidaka T,
|
||
Yamaguchi H,
|
||
Kubuki Y,
|
||
Kitanaka A,
|
||
Matsuoka H,
|
||
Shimoda K</span><br />
|
||
<span class="medgenPMjournal">Viruses</span>
|
||
2022 Mar 29;14(4)
|
||
doi: 10.3390/v14040710.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35458440" target="_blank">35458440</a><a href="/pmc/articles/PMC9030133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35362765">Development and validation of early prediction models for new-onset functional impairment at hospital discharge of ICU admission.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ohbe H,
|
||
Goto T,
|
||
Nakamura K,
|
||
Matsui H,
|
||
Yasunaga H</span><br />
|
||
<span class="medgenPMjournal">Intensive Care Med</span>
|
||
2022 Jun;48(6):679-689.
|
||
Epub 2022 Apr 1
|
||
doi: 10.1007/s00134-022-06688-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35362765" target="_blank">35362765</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34922334">Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaergaard AD,
|
||
Teumer A,
|
||
Witte DR,
|
||
Stanzick KJ,
|
||
Winkler TW,
|
||
Burgess S,
|
||
Ellervik C</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2022 Mar 4;68(3):461-472.
|
||
doi: 10.1093/clinchem/hvab249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34922334" target="_blank">34922334</a><a href="/pmc/articles/PMC7614591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33465709">Predictive performance of blood urea nitrogen to serum albumin ratio in elderly patients with gastrointestinal bleeding.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bae SJ,
|
||
Kim K,
|
||
Yun SJ,
|
||
Lee SH</span><br />
|
||
<span class="medgenPMjournal">Am J Emerg Med</span>
|
||
2021 Mar;41:152-157.
|
||
Epub 2020 Dec 23
|
||
doi: 10.1016/j.ajem.2020.12.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33465709" target="_blank">33465709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28674911">The Basic Metabolic Profile in Heart Failure-Marker and Modifier.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elfar A,
|
||
Sambandam KK</span><br />
|
||
<span class="medgenPMjournal">Curr Heart Fail Rep</span>
|
||
2017 Aug;14(4):311-320.
|
||
doi: 10.1007/s11897-017-0344-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28674911" target="_blank">28674911</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20blood%20urea%20nitrogen%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37944108">Effects of Metabolic Syndrome and Its Components on Chronic Kidney Disease and Renal Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang H,
|
||
Cui Z,
|
||
Quan Z</span><br />
|
||
<span class="medgenPMjournal">Metab Syndr Relat Disord</span>
|
||
2024 Mar;22(2):114-122.
|
||
Epub 2023 Nov 10
|
||
doi: 10.1089/met.2023.0161.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37944108" target="_blank">37944108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36418181">Clinical and laboratory features and factors predicting disease severity in pediatric patients with hemorrhagic fever with renal syndrome caused by Hantaan virus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li R,
|
||
Sun J,
|
||
Chen Y,
|
||
Fan X,
|
||
Wang X,
|
||
Zhang X,
|
||
Zhang K,
|
||
Han Q,
|
||
Liu Z</span><br />
|
||
<span class="medgenPMjournal">J Med Virol</span>
|
||
2023 Jan;95(1):e28339.
|
||
doi: 10.1002/jmv.28339.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36418181" target="_blank">36418181</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36364721">Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fu S,
|
||
Zhang L,
|
||
Ma F,
|
||
Xue S,
|
||
Sun T,
|
||
Xu Z</span><br />
|
||
<span class="medgenPMjournal">Nutrients</span>
|
||
2022 Oct 23;14(21)
|
||
doi: 10.3390/nu14214458.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36364721" target="_blank">36364721</a><a href="/pmc/articles/PMC9654848" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34922334">Obesity and Kidney Function: A Two-Sample Mendelian Randomization Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kjaergaard AD,
|
||
Teumer A,
|
||
Witte DR,
|
||
Stanzick KJ,
|
||
Winkler TW,
|
||
Burgess S,
|
||
Ellervik C</span><br />
|
||
<span class="medgenPMjournal">Clin Chem</span>
|
||
2022 Mar 4;68(3):461-472.
|
||
doi: 10.1093/clinchem/hvab249.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34922334" target="_blank">34922334</a><a href="/pmc/articles/PMC7614591" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/33465709">Predictive performance of blood urea nitrogen to serum albumin ratio in elderly patients with gastrointestinal bleeding.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bae SJ,
|
||
Kim K,
|
||
Yun SJ,
|
||
Lee SH</span><br />
|
||
<span class="medgenPMjournal">Am J Emerg Med</span>
|
||
2021 Mar;41:152-157.
|
||
Epub 2020 Dec 23
|
||
doi: 10.1016/j.ajem.2020.12.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33465709" target="_blank">33465709</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20blood%20urea%20nitrogen%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mehri A,
|
||
Sotoodeh Ghorbani S,
|
||
Farhadi-Babadi K,
|
||
Rahimi E,
|
||
Barati Z,
|
||
Taherpour N,
|
||
Izadi N,
|
||
Shahbazi F,
|
||
Mokhayeri Y,
|
||
Seifi A,
|
||
Fallah S,
|
||
Feyzi R,
|
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Etemed K,
|
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Hashemi Nazari SS</span><br />
|
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<span class="medgenPMjournal">J Intensive Care Med</span>
|
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2023 Sep;38(9):825-837.
|
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Epub 2023 Mar 28
|
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doi: 10.1177/08850666231166344.
|
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<div class="nl"><a target="_blank" href="/pubmed/8267150">Association of preoperative risk factors with postoperative acute renal failure.</a></div>
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Roizen MF,
|
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Aronson S,
|
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Thisted RA</span><br />
|
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<span class="medgenPMjournal">Anesth Analg</span>
|
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1994 Jan;78(1):143-9.
|
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doi: 10.1213/00000539-199401000-00023.
|
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<span class="bold">PMID: </span><a href="/pubmed/8267150" target="_blank">8267150</a></div>
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