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<meta name="keywords" content="C2364164, abnormality of fluid regulation, disorder of fluid balance, finding, fluid imbalance, fluid volume disorder, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="An abnormality of the regulation of body fluids." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Abnormality of fluid regulation (Concept Id: C2364164)
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<!--
UID=748573
ConceptID=C2364164
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormality of fluid regulation</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>748573</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2364164</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Disorder of fluid balance; Fluid imbalance; Fluid volume disorder</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Fluid imbalance (190902006); Fluid volume disorder (1860003); Disorder of fluid balance (1860003)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0011032">HP:0011032</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">An abnormality of the regulation of body fluids. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Abnormality of fluid regulation</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/868551" ref="tree=MeSH" title="MedGen record for Abnormal homeostasis">Abnormal homeostasis</a></span><ul><li><span class="matched_ds">Abnormality of fluid regulation</span><ul><li><span class="TLline"><a href="/medgen/1863588" ref="tree=MeSH" title="MedGen record for Abnormal serum osmolality">Abnormal serum osmolality</a></span><ul><li><span class="TLline"><a href="/medgen/1863820" ref="tree=MeSH" title="MedGen record for Elevated osmolality gap">Elevated osmolality gap</a></span></li><li><span class="TLline"><a href="/medgen/343717" ref="tree=MeSH" title="MedGen record for High serum osmolality">High serum osmolality</a></span></li><li><span class="TLline"><a href="/medgen/1863881" ref="tree=MeSH" title="MedGen record for Low serum osmolality">Low serum osmolality</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/8273" ref="tree=MeSH" title="MedGen record for Dehydration">Dehydration</a></span><ul><li><span class="TLline"><a href="/medgen/340564" ref="tree=MeSH" title="MedGen record for Hypernatremic dehydration">Hypernatremic dehydration</a></span></li><li><span class="TLline"><a href="/medgen/205119" ref="tree=MeSH" title="MedGen record for Hypertonic dehydration">Hypertonic dehydration</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/4451" ref="tree=MeSH" title="MedGen record for Edema">Edema</a></span><ul><li><span class="TLline"><a href="/medgen/101794" ref="tree=MeSH" title="MedGen record for Anasarca">Anasarca</a></span></li><li><span class="TLline"><a href="/medgen/4452" ref="tree=MeSH" title="MedGen record for Cardiac edema">Cardiac edema</a></span></li><li><span class="TLline"><a href="/medgen/2337" ref="tree=MeSH" title="MedGen record for Cerebral edema">Cerebral edema</a></span><ul><li><span class="TLline"><a href="/medgen/887794" ref="tree=MeSH" title="MedGen record for Peritumoral Brain Edema">Peritumoral Brain Edema</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124393" ref="tree=MeSH" title="MedGen record for Chemosis">Chemosis</a></span></li><li><span class="TLline"><a href="/medgen/1056896" ref="tree=MeSH" title="MedGen record for Clavicular edema">Clavicular edema</a></span></li><li><span class="TLline"><a href="/medgen/3242" ref="tree=MeSH" title="MedGen record for corneal edema">corneal edema</a></span><ul><li><span class="TLline"><a href="/medgen/96883" ref="tree=MeSH" title="MedGen record for Corneal stromal edema">Corneal stromal edema</a></span></li><li><span class="TLline"><a href="/medgen/96882" ref="tree=MeSH" title="MedGen record for Fine corneal edema">Fine corneal edema</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/752076" ref="tree=MeSH" title="MedGen record for Edema of the dorsum of hands">Edema of the dorsum of hands</a></span></li><li><span class="TLline"><a href="/medgen/108296" ref="tree=MeSH" title="MedGen record for Edema of trunk">Edema of trunk</a></span></li><li><span class="TLline"><a href="/medgen/154241" ref="tree=MeSH" title="MedGen record for Facial edema">Facial edema</a></span></li><li><span class="TLline"><a href="/medgen/376817" ref="tree=MeSH" title="MedGen record for Generalized edema">Generalized edema</a></span></li><li><span class="TLline"><a href="/medgen/101795" ref="tree=MeSH" title="MedGen record for Genital edema">Genital edema</a></span></li><li><span class="TLline"><a href="/medgen/6947" ref="tree=MeSH" title="MedGen record for Hydrops fetalis">Hydrops fetalis</a></span><ul><li><span class="TLline"><a href="/medgen/105328" ref="tree=MeSH" title="MedGen record for Immune hydrops fetalis">Immune hydrops fetalis</a></span></li><li><span class="TLline"><a href="/medgen/105327" ref="tree=MeSH" title="MedGen record for Non-immune hydrops fetalis">Non-immune hydrops fetalis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/320555" ref="tree=MeSH" title="MedGen record for Hyperkeratosis over edematous areas">Hyperkeratosis over edematous areas</a></span></li><li><span class="TLline"><a href="/medgen/870387" ref="tree=MeSH" title="MedGen record for Hypoproteinemic edema">Hypoproteinemic edema</a></span></li><li><span class="TLline"><a href="/medgen/6017" ref="tree=MeSH" title="MedGen record for Laryngeal edema">Laryngeal edema</a></span></li><li><span class="TLline"><a href="/medgen/4453" ref="tree=MeSH" title="MedGen record for Localized edema">Localized edema</a></span></li><li><span class="TLline"><a href="/medgen/6155" ref="tree=MeSH" title="MedGen record for Lymphedema">Lymphedema</a></span><ul><li><span class="TLline"><a href="/medgen/904196" ref="tree=MeSH" title="MedGen record for Breast Cancer Lymphedemas">Breast Cancer Lymphedemas</a></span></li><li><span class="TLline"><a href="/medgen/78533" ref="tree=MeSH" title="MedGen record for Chronic acquired lymphedema">Chronic acquired lymphedema</a></span></li><li><span class="TLline"><a href="/medgen/8582" ref="tree=MeSH" title="MedGen record for Elephantiasis">Elephantiasis</a></span></li><li><span class="TLline"><a href="/medgen/8583" ref="tree=MeSH" title="MedGen record for Filarial elephantiasis">Filarial elephantiasis</a></span></li><li><span class="TLline"><a href="/medgen/309963" ref="tree=MeSH" title="MedGen record for Hereditary lymphedema type I">Hereditary lymphedema type I</a></span></li><li><span class="TLline"><a href="/medgen/1714608" ref="tree=MeSH" title="MedGen record for Lymphedema of the Head and Neck">Lymphedema of the Head and Neck</a></span></li><li><span class="TLline"><a href="/medgen/488327" ref="tree=MeSH" title="MedGen record for Non-Filarial Lymphedema">Non-Filarial Lymphedema</a></span></li><li><span class="TLline"><a href="/medgen/320552" ref="tree=MeSH" title="MedGen record for Predominantly lower limb lymphedema">Predominantly lower limb lymphedema</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/66012" ref="tree=MeSH" title="MedGen record for Neck Edema">Neck Edema</a></span></li><li><span class="TLline"><a href="/medgen/224749" ref="tree=MeSH" title="MedGen record for Non-pitting edema">Non-pitting edema</a></span></li><li><span class="TLline"><a href="/medgen/10565" ref="tree=MeSH" title="MedGen record for Optic papillitis">Optic papillitis</a></span></li><li><span class="TLline"><a href="/medgen/98085" ref="tree=MeSH" title="MedGen record for Peau d'orange">Peau d'orange</a></span></li><li><span class="TLline"><a href="/medgen/56223" ref="tree=MeSH" title="MedGen record for Periorbital edema">Periorbital edema</a></span><ul><li><span class="TLline"><a href="/medgen/57877" ref="tree=MeSH" title="MedGen record for Palpebral edema">Palpebral edema</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/39321" ref="tree=MeSH" title="MedGen record for Peripheral edema">Peripheral edema</a></span><ul><li><span class="TLline"><a href="/medgen/1760647" ref="tree=MeSH" title="MedGen record for Acral Edema">Acral Edema</a></span></li><li><span class="TLline"><a href="/medgen/154355" ref="tree=MeSH" title="MedGen record for Edema of foot">Edema of foot</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/137681" ref="tree=MeSH" title="MedGen record for Pitting edema">Pitting edema</a></span></li><li><span class="TLline"><a href="/medgen/508785" ref="tree=MeSH" title="MedGen record for Tongue edema">Tongue edema</a></span></li><li><span class="TLline"><a href="/medgen/442997" ref="tree=MeSH" title="MedGen record for Vasogenic Edema">Vasogenic Edema</a></span></li><li><span class="TLline"><a href="/medgen/305584" ref="tree=MeSH" title="MedGen record for Visceral Edema">Visceral Edema</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/36209190">Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu D,
Huang SY,
Sun JH,
Zhang HC,
Cai QL,
Gao C,
Li L,
Cao J,
Xu F,
Zhou Y,
Guan CX,
Jin SW,
Deng J,
Fang XM,
Jiang JX,
Zeng L</span><br />
<span class="medgenPMjournal">Mil Med Res</span>
2022 Oct 9;9(1):56.
doi: 10.1186/s40779-022-00422-y.
<span class="bold">PMID: </span><a href="/pubmed/36209190" target="_blank">36209190</a><a href="/pmc/articles/PMC9547753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31606238">Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seay NW,
Lehrich RW,
Greenberg A</span><br />
<span class="medgenPMjournal">Am J Kidney Dis</span>
2020 Feb;75(2):272-286.
Epub 2019 Oct 10
doi: 10.1053/j.ajkd.2019.07.014.
<span class="bold">PMID: </span><a href="/pubmed/31606238" target="_blank">31606238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26077742">Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bockenhauer D,
Bichet DG</span><br />
<span class="medgenPMjournal">Nat Rev Nephrol</span>
2015 Oct;11(10):576-88.
Epub 2015 Jun 16
doi: 10.1038/nrneph.2015.89.
<span class="bold">PMID: </span><a href="/pubmed/26077742" target="_blank">26077742</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(abnormality%20of%20fluid%20regulation)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (50)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/36863088">PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mu L,
Ye Z,
Hu J,
Zhang Y,
Chen K,
Sun H,
Li R,
Mao W,
Long X,
Zhang C,
Lai Y,
Liu J,
Zhao Y,
Qiao J</span><br />
<span class="medgenPMjournal">EBioMedicine</span>
2023 Mar;89:104492.
Epub 2023 Feb 28
doi: 10.1016/j.ebiom.2023.104492.
<span class="bold">PMID: </span><a href="/pubmed/36863088" target="_blank">36863088</a><a href="/pmc/articles/PMC9986518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34579153">Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Naber T,
Purohit S</span><br />
<span class="medgenPMjournal">Nutrients</span>
2021 Sep 19;13(9)
doi: 10.3390/nu13093277.
<span class="bold">PMID: </span><a href="/pubmed/34579153" target="_blank">34579153</a><a href="/pmc/articles/PMC8467342" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34161185">Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumariya S,
Ubba V,
Jha RK,
Gayen JR</span><br />
<span class="medgenPMjournal">Autophagy</span>
2021 Oct;17(10):2706-2733.
Epub 2021 Jun 23
doi: 10.1080/15548627.2021.1938914.
<span class="bold">PMID: </span><a href="/pubmed/34161185" target="_blank">34161185</a><a href="/pmc/articles/PMC8526011" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26903336">Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar-Hari M,
Phillips GS,
Levy ML,
Seymour CW,
Liu VX,
Deutschman CS,
Angus DC,
Rubenfeld GD,
Singer M;
Sepsis Definitions Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2016 Feb 23;315(8):775-87.
doi: 10.1001/jama.2016.0289.
<span class="bold">PMID: </span><a href="/pubmed/26903336" target="_blank">26903336</a><a href="/pmc/articles/PMC4910392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23720252">Hypertension: physiology and pathophysiology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hall JE,
Granger JP,
do Carmo JM,
da Silva AA,
Dubinion J,
George E,
Hamza S,
Speed J,
Hall ME</span><br />
<span class="medgenPMjournal">Compr Physiol</span>
2012 Oct;2(4):2393-442.
doi: 10.1002/cphy.c110058.
<span class="bold">PMID: </span><a href="/pubmed/23720252" target="_blank">23720252</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (373)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36209190">Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu D,
Huang SY,
Sun JH,
Zhang HC,
Cai QL,
Gao C,
Li L,
Cao J,
Xu F,
Zhou Y,
Guan CX,
Jin SW,
Deng J,
Fang XM,
Jiang JX,
Zeng L</span><br />
<span class="medgenPMjournal">Mil Med Res</span>
2022 Oct 9;9(1):56.
doi: 10.1186/s40779-022-00422-y.
<span class="bold">PMID: </span><a href="/pubmed/36209190" target="_blank">36209190</a><a href="/pmc/articles/PMC9547753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35369665">Comprehensive Assessment of Fluid Status by Point-of-Care Ultrasonography.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Argaiz ER,
Koratala A,
Reisinger N</span><br />
<span class="medgenPMjournal">Kidney360</span>
2021 Aug 26;2(8):1326-1338.
Epub 2021 May 27
doi: 10.34067/KID.0006482020.
<span class="bold">PMID: </span><a href="/pubmed/35369665" target="_blank">35369665</a><a href="/pmc/articles/PMC8676400" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31606238">Diagnosis and Management of Disorders of Body Tonicity-Hyponatremia and Hypernatremia: Core Curriculum 2020.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Seay NW,
Lehrich RW,
Greenberg A</span><br />
<span class="medgenPMjournal">Am J Kidney Dis</span>
2020 Feb;75(2):272-286.
Epub 2019 Oct 10
doi: 10.1053/j.ajkd.2019.07.014.
<span class="bold">PMID: </span><a href="/pubmed/31606238" target="_blank">31606238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26256071">Hydrocephalus in children.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kahle KT,
Kulkarni AV,
Limbrick DD Jr,
Warf BC</span><br />
<span class="medgenPMjournal">Lancet</span>
2016 Feb 20;387(10020):788-99.
Epub 2015 Aug 6
doi: 10.1016/S0140-6736(15)60694-8.
<span class="bold">PMID: </span><a href="/pubmed/26256071" target="_blank">26256071</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26077742">Pathophysiology, diagnosis and management of nephrogenic diabetes insipidus.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bockenhauer D,
Bichet DG</span><br />
<span class="medgenPMjournal">Nat Rev Nephrol</span>
2015 Oct;11(10):576-88.
Epub 2015 Jun 16
doi: 10.1038/nrneph.2015.89.
<span class="bold">PMID: </span><a href="/pubmed/26077742" target="_blank">26077742</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (428)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/36209190">Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu D,
Huang SY,
Sun JH,
Zhang HC,
Cai QL,
Gao C,
Li L,
Cao J,
Xu F,
Zhou Y,
Guan CX,
Jin SW,
Deng J,
Fang XM,
Jiang JX,
Zeng L</span><br />
<span class="medgenPMjournal">Mil Med Res</span>
2022 Oct 9;9(1):56.
doi: 10.1186/s40779-022-00422-y.
<span class="bold">PMID: </span><a href="/pubmed/36209190" target="_blank">36209190</a><a href="/pmc/articles/PMC9547753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35328738">Autosomal Dominant Polycystic Kidney Disease: From Pathophysiology of Cystogenesis to Advances in the Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Reiterová J,
Tesař V</span><br />
<span class="medgenPMjournal">Int J Mol Sci</span>
2022 Mar 19;23(6)
doi: 10.3390/ijms23063317.
<span class="bold">PMID: </span><a href="/pubmed/35328738" target="_blank">35328738</a><a href="/pmc/articles/PMC8949594" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31594261">A physiological approach to fluid and electrolyte management of the preterm infant: Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Segar JL</span><br />
<span class="medgenPMjournal">J Neonatal Perinatal Med</span>
2020;13(1):11-19.
doi: 10.3233/NPM-190309.
<span class="bold">PMID: </span><a href="/pubmed/31594261" target="_blank">31594261</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26903336">Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar-Hari M,
Phillips GS,
Levy ML,
Seymour CW,
Liu VX,
Deutschman CS,
Angus DC,
Rubenfeld GD,
Singer M;
Sepsis Definitions Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2016 Feb 23;315(8):775-87.
doi: 10.1001/jama.2016.0289.
<span class="bold">PMID: </span><a href="/pubmed/26903336" target="_blank">26903336</a><a href="/pmc/articles/PMC4910392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21742796">Normalization of the vasculature for treatment of cancer and other diseases.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Goel S,
Duda DG,
Xu L,
Munn LL,
Boucher Y,
Fukumura D,
Jain RK</span><br />
<span class="medgenPMjournal">Physiol Rev</span>
2011 Jul;91(3):1071-121.
doi: 10.1152/physrev.00038.2010.
<span class="bold">PMID: </span><a href="/pubmed/21742796" target="_blank">21742796</a><a href="/pmc/articles/PMC3258432" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (239)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/37270259">Pathophysiological interpretation of fetal heart rate tracings in clinical practice.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jia YJ,
Ghi T,
Pereira S,
Gracia Perez-Bonfils A,
Chandraharan E</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 Jun;228(6):622-644.
doi: 10.1016/j.ajog.2022.05.023.
<span class="bold">PMID: </span><a href="/pubmed/37270259" target="_blank">37270259</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37258679">Axonemal structures reveal mechanoregulatory and disease mechanisms.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Walton T,
Gui M,
Velkova S,
Fassad MR,
Hirst RA,
Haarman E,
O'Callaghan C,
Bottier M,
Burgoyne T,
Mitchison HM,
Brown A</span><br />
<span class="medgenPMjournal">Nature</span>
2023 Jun;618(7965):625-633.
Epub 2023 May 31
doi: 10.1038/s41586-023-06140-2.
<span class="bold">PMID: </span><a href="/pubmed/37258679" target="_blank">37258679</a><a href="/pmc/articles/PMC10266980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36387907">Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Du X,
Yang L,
Kong L,
Sun Y,
Shen K,
Cai Y,
Sun H,
Zhang B,
Guo S,
Zhang A,
Wang X</span><br />
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
2022;13:1037164.
Epub 2022 Oct 27
doi: 10.3389/fendo.2022.1037164.
<span class="bold">PMID: </span><a href="/pubmed/36387907" target="_blank">36387907</a><a href="/pmc/articles/PMC9646596" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36209190">Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Liu D,
Huang SY,
Sun JH,
Zhang HC,
Cai QL,
Gao C,
Li L,
Cao J,
Xu F,
Zhou Y,
Guan CX,
Jin SW,
Deng J,
Fang XM,
Jiang JX,
Zeng L</span><br />
<span class="medgenPMjournal">Mil Med Res</span>
2022 Oct 9;9(1):56.
doi: 10.1186/s40779-022-00422-y.
<span class="bold">PMID: </span><a href="/pubmed/36209190" target="_blank">36209190</a><a href="/pmc/articles/PMC9547753" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34161185">Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumariya S,
Ubba V,
Jha RK,
Gayen JR</span><br />
<span class="medgenPMjournal">Autophagy</span>
2021 Oct;17(10):2706-2733.
Epub 2021 Jun 23
doi: 10.1080/15548627.2021.1938914.
<span class="bold">PMID: </span><a href="/pubmed/34161185" target="_blank">34161185</a><a href="/pmc/articles/PMC8526011" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (220)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/37270259">Pathophysiological interpretation of fetal heart rate tracings in clinical practice.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jia YJ,
Ghi T,
Pereira S,
Gracia Perez-Bonfils A,
Chandraharan E</span><br />
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
2023 Jun;228(6):622-644.
doi: 10.1016/j.ajog.2022.05.023.
<span class="bold">PMID: </span><a href="/pubmed/37270259" target="_blank">37270259</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35549375">Cardiorenal Syndrome: The Role of Neural Connections Between the Heart and the Kidneys.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Patel KP,
Katsurada K,
Zheng H</span><br />
<span class="medgenPMjournal">Circ Res</span>
2022 May 13;130(10):1601-1617.
Epub 2022 May 12
doi: 10.1161/CIRCRESAHA.122.319989.
<span class="bold">PMID: </span><a href="/pubmed/35549375" target="_blank">35549375</a><a href="/pmc/articles/PMC9179008" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34161185">Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kumariya S,
Ubba V,
Jha RK,
Gayen JR</span><br />
<span class="medgenPMjournal">Autophagy</span>
2021 Oct;17(10):2706-2733.
Epub 2021 Jun 23
doi: 10.1080/15548627.2021.1938914.
<span class="bold">PMID: </span><a href="/pubmed/34161185" target="_blank">34161185</a><a href="/pmc/articles/PMC8526011" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26903336">Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar-Hari M,
Phillips GS,
Levy ML,
Seymour CW,
Liu VX,
Deutschman CS,
Angus DC,
Rubenfeld GD,
Singer M;
Sepsis Definitions Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2016 Feb 23;315(8):775-87.
doi: 10.1001/jama.2016.0289.
<span class="bold">PMID: </span><a href="/pubmed/26903336" target="_blank">26903336</a><a href="/pmc/articles/PMC4910392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23720252">Hypertension: physiology and pathophysiology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hall JE,
Granger JP,
do Carmo JM,
da Silva AA,
Dubinion J,
George E,
Hamza S,
Speed J,
Hall ME</span><br />
<span class="medgenPMjournal">Compr Physiol</span>
2012 Oct;2(4):2393-442.
doi: 10.1002/cphy.c110058.
<span class="bold">PMID: </span><a href="/pubmed/23720252" target="_blank">23720252</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (367)</a></div></div>
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<div class="portlet mgSection" id="ID_104">
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<div class="nl"><a target="_blank" href="/pubmed/38714912">Sleep duration, sleep efficiency, and amyloid β among cognitively healthy later-life adults: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Moon C,
Schneider A,
Cho YE,
Zhang M,
Dang H,
Vu K</span><br />
<span class="medgenPMjournal">BMC Geriatr</span>
2024 May 8;24(1):408.
doi: 10.1186/s12877-024-05010-4.
<span class="bold">PMID: </span><a href="/pubmed/38714912" target="_blank">38714912</a><a href="/pmc/articles/PMC11076214" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31048445">Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Smyth LJ,
Cañadas-Garre M,
Cappa RC,
Maxwell AP,
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<span class="medgenPMjournal">BMJ Open</span>
2019 May 1;9(4):e026777.
doi: 10.1136/bmjopen-2018-026777.
<span class="bold">PMID: </span><a href="/pubmed/31048445" target="_blank">31048445</a><a href="/pmc/articles/PMC6501980" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28120482">Abnormal peritoneal regulation of chemokine activation-The role of IL-8 in pathogenesis of endometriosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sikora J,
Smycz-Kubańska M,
Mielczarek-Palacz A,
Kondera-Anasz Z</span><br />
<span class="medgenPMjournal">Am J Reprod Immunol</span>
2017 Apr;77(4)
Epub 2017 Jan 25
doi: 10.1111/aji.12622.
<span class="bold">PMID: </span><a href="/pubmed/28120482" target="_blank">28120482</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26903336">Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shankar-Hari M,
Phillips GS,
Levy ML,
Seymour CW,
Liu VX,
Deutschman CS,
Angus DC,
Rubenfeld GD,
Singer M;
Sepsis Definitions Task Force</span><br />
<span class="medgenPMjournal">JAMA</span>
2016 Feb 23;315(8):775-87.
doi: 10.1001/jama.2016.0289.
<span class="bold">PMID: </span><a href="/pubmed/26903336" target="_blank">26903336</a><a href="/pmc/articles/PMC4910392" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21790682">Systematic review: the pathophysiology and management of polycystic liver disease.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Temmerman F,
Missiaen L,
Bammens B,
Laleman W,
Cassiman D,
Verslype C,
van Pelt J,
Nevens F</span><br />
<span class="medgenPMjournal">Aliment Pharmacol Ther</span>
2011 Oct;34(7):702-13.
Epub 2011 Jul 26
doi: 10.1111/j.1365-2036.2011.04783.x.
<span class="bold">PMID: </span><a href="/pubmed/21790682" target="_blank">21790682</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormality%20of%20fluid%20regulation%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div></div>
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