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<!--
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||
UID=7317
|
||
ConceptID=C0023449
|
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-->
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Acute lymphoid leukemia<span class="h1sub">(ALL)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7317</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023449</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Acute lymphoblastic leukemia; Acute lymphocytic leukemia; ALL; Familial Acute Lymphocytic Leukemia; Leukemia, acute lymphoblastic, somatic; Lymphoblastic leukemia</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>ALL - Acute lymphoblastic leukemia (91857003); Acute lymphoid leukemia (91857003); Lymphoblastic leukemia (128822004); Acute lymphocytic leukemia (128822004); Acute lymphoblastic leukemia-lymphoma (128822004); Acute lymphoblastic leukemia (128822004); Acute lymphatic leukemia (128822004); Acute lymphoid leukemia, disease (91857003)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="BAX - ID: 581 - NCBI Gene" href="/gene/581" class="medgenPMinfo">BAX</a> (19q13.33); <a target="_blank" title="BCR - ID: 613 - NCBI Gene" href="/gene/613" class="medgenPMinfo">BCR</a> (22q11.23); <a target="_blank" title="FLT3 - ID: 2322 - NCBI Gene" href="/gene/2322" class="medgenPMinfo">FLT3</a> (13q12.2); <a target="_blank" title="GNB1 - ID: 2782 - NCBI Gene" href="/gene/2782" class="medgenPMinfo">GNB1</a> (1p36.33); <a target="_blank" title="NBN - ID: 4683 - NCBI Gene" href="/gene/4683" class="medgenPMinfo">NBN</a> (8q21.3); <a target="_blank" title="NUP214 - ID: 8021 - NCBI Gene" href="/gene/8021" class="medgenPMinfo">NUP214</a> (9q34.13); <a target="_blank" title="TAL1 - ID: 6886 - NCBI Gene" href="/gene/6886" class="medgenPMinfo">TAL1</a> (1p33); <a target="_blank" title="TAL2 - ID: 6887 - NCBI Gene" href="/gene/6887" class="medgenPMinfo">TAL2</a> (9q31.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0006721">HP:0006721</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0004967" target="_blank">MONDO:0004967</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/613065" target="_blank">613065</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=513">ORPHA513</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
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||
|
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<div class="portlet mgSection" id="ID_102">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_7317"><div><strong>Acute lymphoid leukemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7317</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023449</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7317">Feature record</a> | <a href="/medgen?term=%22Acute%20lymphoid%20leukemia%22%5BClinical%20Features%5D%20OR%207317%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7317" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acute lymphoid leukemia</a></span></li></ul></li></ul></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023449[DISCUI]&test_type=Clinical" ref="ncbi_uid=7317">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0023449[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=7317">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=7317" ref="ncbi_uid=7317">V</a></span></span><span class="TLline">Acute lymphoid leukemia</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023452[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=44122">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/44122" ref="tree=GTR&ncbi_uid=44122&link_uid=44122" title="View MedGen record for 'Childhood acute lymphoblastic leukemia'">Childhood acute lymphoblastic leukemia</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/138213" ref="tree=MeSH" title="MedGen record for Hematologic neoplasm">Hematologic neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/9725" ref="tree=MeSH" title="MedGen record for Leukemia">Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/43225" ref="tree=MeSH" title="MedGen record for Acute leukemia">Acute leukemia</a></span><ul><li><span class="matched_ds">Acute lymphoid leukemia</span><ul><li><span class="TLline"><a href="/medgen/890737" ref="tree=MeSH" title="MedGen record for Acute Lymphoblastic Leukemia by Gene Expression Profile">Acute Lymphoblastic Leukemia by Gene Expression Profile</a></span><ul><li><span class="TLline"><a href="/medgen/881413" ref="tree=MeSH" title="MedGen record for Acute Lymphoblastic Leukemia by ROSE Cluster">Acute Lymphoblastic Leukemia by ROSE Cluster</a></span><ul><li><span class="TLline"><a href="/medgen/881956" ref="tree=MeSH" title="MedGen record for Ring chromosome 5">Ring chromosome 5</a></span></li><li><span class="TLline"><a href="/medgen/885976" ref="tree=MeSH" title="MedGen record for ROSE Cluster 1">ROSE Cluster 1</a></span></li><li><span class="TLline"><a href="/medgen/889935" ref="tree=MeSH" title="MedGen record for ROSE Cluster 2">ROSE Cluster 2</a></span></li><li><span class="TLline"><a href="/medgen/887317" ref="tree=MeSH" title="MedGen record for ROSE Cluster 3">ROSE Cluster 3</a></span></li><li><span class="TLline"><a href="/medgen/887052" ref="tree=MeSH" title="MedGen record for ROSE Cluster 4">ROSE Cluster 4</a></span></li><li><span class="TLline"><a href="/medgen/885648" ref="tree=MeSH" title="MedGen record for ROSE Cluster 6">ROSE Cluster 6</a></span></li><li><span class="TLline"><a href="/medgen/885926" ref="tree=MeSH" title="MedGen record for ROSE Cluster 7">ROSE Cluster 7</a></span></li><li><span class="TLline"><a href="/medgen/888040" ref="tree=MeSH" title="MedGen record for ROSE Cluster 8">ROSE Cluster 8</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/887378" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia, BCR-ABL1-Like">B Acute Lymphoblastic Leukemia, BCR-ABL1-Like</a></span><ul><li><span class="TLline"><a href="/medgen/1626864" ref="tree=MeSH" title="MedGen record for Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like">Recurrent B Acute Lymphoblastic Leukemia, BCR-ABL1-Like</a></span></li><li><span class="TLline"><a href="/medgen/1626003" ref="tree=MeSH" title="MedGen record for Refractory B Acute Lymphoblastic Leukemia, BCR-ABL1-Like">Refractory B Acute Lymphoblastic Leukemia, BCR-ABL1-Like</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/890499" ref="tree=MeSH" title="MedGen record for DDIT4L Acute Lymphoblastic Leukemia">DDIT4L Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/199693" ref="tree=MeSH" title="MedGen record for Adult acute lymphoblastic leukemia">Adult acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/79010" ref="tree=MeSH" title="MedGen record for B-cell adult acute lymphocytic leukemia">B-cell adult acute lymphocytic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/859700" ref="tree=MeSH" title="MedGen record for Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1">Adult B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/124510" ref="tree=MeSH" title="MedGen record for Recurrent Adult Acute Lymphoblastic Leukemia">Recurrent Adult Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/925834" ref="tree=MeSH" title="MedGen record for Refractory Adult Acute Lymphoblastic Leukemia">Refractory Adult Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/79009" ref="tree=MeSH" title="MedGen record for T-cell adult acute lymphocytic leukemia">T-cell adult acute lymphocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/231365" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia">Aleukemic Acute Lymphoblastic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/231366" ref="tree=MeSH" title="MedGen record for Aleukemic Acute Lymphoblastic Leukemia Cutis">Aleukemic Acute Lymphoblastic Leukemia Cutis</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/226949" ref="tree=MeSH" title="MedGen record for B-cell acute lymphoblastic leukemia">B-cell acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1374530" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21">B Acute Lymphoblastic Leukemia with Intrachromosomal Amplification of Chromosome 21</a></span></li><li><span class="TLline"><a href="/medgen/396855" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1">B Acute Lymphoblastic Leukemia with t(12;21)(p13.2;q22.1); ETV6-RUNX1</a></span></li><li><span class="TLline"><a href="/medgen/396856" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); TCF3-PBX1">B Acute Lymphoblastic Leukemia with t(1;19)(q23;p13.3); TCF3-PBX1</a></span></li><li><span class="TLline"><a href="/medgen/437495" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia with t(5;14)(q31.1;q32.3); IL3-IGH">B Acute Lymphoblastic Leukemia with t(5;14)(q31.1;q32.3); IL3-IGH</a></span></li><li><span class="TLline"><a href="/medgen/397153" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged">B Acute Lymphoblastic Leukemia with t(v;11q23.3); KMT2A Rearranged</a></span></li><li><span class="TLline"><a href="/medgen/927478" ref="tree=MeSH" title="MedGen record for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative">B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative</a></span></li><li><span class="TLline"><a href="/medgen/83526" ref="tree=MeSH" title="MedGen record for B-cell childhood acute lymphoblastic leukemia">B-cell childhood acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/416995" ref="tree=MeSH" title="MedGen record for Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1">Childhood B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/394941" ref="tree=MeSH" title="MedGen record for Hyperdiploid B Acute Lymphoblastic Leukemia">Hyperdiploid B Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/394638" ref="tree=MeSH" title="MedGen record for Hypodiploid B Acute Lymphoblastic Leukemia">Hypodiploid B Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/313581" ref="tree=MeSH" title="MedGen record for Ph-positive acute lymphoblastic leukemia">Ph-positive acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1791169" ref="tree=MeSH" title="MedGen record for Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1">Recurrent B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1</a></span></li><li><span class="TLline"><a href="/medgen/1792124" ref="tree=MeSH" title="MedGen record for Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1">Refractory B Acute Lymphoblastic Leukemia with t(9;22)(q34.1;q11.2); BCR-ABL1</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1634726" ref="tree=MeSH" title="MedGen record for Recurrent B Acute Lymphoblastic Leukemia">Recurrent B Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1636080" ref="tree=MeSH" title="MedGen record for Refractory B Acute Lymphoblastic Leukemia">Refractory B Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/44122" ref="tree=MeSH" title="MedGen record for Childhood acute lymphoblastic leukemia">Childhood acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/83527" ref="tree=MeSH" title="MedGen record for Adult L1 Acute Lymphoblastic Leukemia">Adult L1 Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/852470" ref="tree=MeSH" title="MedGen record for Childhood L1 Acute Lymphoblastic Leukemia">Childhood L1 Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/889772" ref="tree=MeSH" title="MedGen record for Infant Acute Lymphoblastic Leukemia">Infant Acute Lymphoblastic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/890208" ref="tree=MeSH" title="MedGen record for Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement">Infant Acute Lymphoblastic Leukemia with KMT2A Rearrangement</a></span></li><li><span class="TLline"><a href="/medgen/889234" ref="tree=MeSH" title="MedGen record for Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement">Infant Acute Lymphoblastic Leukemia without KMT2A Rearrangement</a></span></li><li><span class="TLline"><a href="/medgen/926423" ref="tree=MeSH" title="MedGen record for Infant T Acute Lymphoblastic Leukemia">Infant T Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/75831" ref="tree=MeSH" title="MedGen record for Recurrent Childhood Acute Lymphoblastic Leukemia">Recurrent Childhood Acute Lymphoblastic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1388290" ref="tree=MeSH" title="MedGen record for Recurrent Childhood T Acute Lymphoblastic Leukemia">Recurrent Childhood T Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/889646" ref="tree=MeSH" title="MedGen record for Refractory Childhood Acute Lymphoblastic Leukemia">Refractory Childhood Acute Lymphoblastic Leukemia</a></span></li><li><span class="TLline"><a href="/medgen/75996" ref="tree=MeSH" title="MedGen record for T-cell childhood acute lymphocytic leukemia">T-cell childhood acute lymphocytic leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/83896" ref="tree=MeSH" title="MedGen record for Precursor B-cell acute lymphoblastic leukemia">Precursor B-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/976286" ref="tree=MeSH" title="MedGen record for Precursor T-cell acute lymphoblastic leukemia">Precursor T-cell acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/1632670" ref="tree=MeSH" title="MedGen record for Recurrent Acute Lymphoblastic Leukemia">Recurrent Acute Lymphoblastic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1661578" ref="tree=MeSH" title="MedGen record for Recurrent T Acute Lymphoblastic Leukemia">Recurrent T Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1612918" ref="tree=MeSH" title="MedGen record for Refractory Acute Lymphoblastic Leukemia">Refractory Acute Lymphoblastic Leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1655206" ref="tree=MeSH" title="MedGen record for Refractory T Acute Lymphoblastic Leukemia">Refractory T Acute Lymphoblastic Leukemia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/368378" ref="tree=MeSH" title="MedGen record for T-cell acute lymphoblastic leukemia">T-cell acute lymphoblastic leukemia</a></span><ul><li><span class="TLline"><a href="/medgen/1385175" ref="tree=MeSH" title="MedGen record for Early T cell progenitor acute lymphoblastic leukemia">Early T cell progenitor acute lymphoblastic leukemia</a></span></li><li><span class="TLline"><a href="/medgen/313961" ref="tree=MeSH" title="MedGen record for Mediastinal T Acute Lymphoblastic Leukemia">Mediastinal T Acute Lymphoblastic Leukemia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="divPopper rprt" id="rdis_439"><div><strong>Ataxia-telangiectasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>439</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0004135</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The phenotypic spectrum of ataxia-telangiectasia (A-T), a multisystem disorder, is a continuum ranging from classic A-T at the severe end and variant A-T at the milder end. Nonetheless, distinguishing between classic A-T and variant A-T on this spectrum helps understand differences in disease course, rate of progression, and life expectancy. Classic A-T is characterized by childhood onset of progressive neurologic manifestations (initially cerebellar ataxia, followed typically by extrapyramidal involvement and peripheral sensorimotor neuropathy), immunodeficiency (variably associated with abnormalities of humoral immunity, cellular immunity, or combined immune deficiency), pulmonary disease (resulting from recurrent infections, immune deficiency, aspiration, interstitial lung disease, and neurologic abnormalities), and increased risk of malignancy. Although it is generally accepted that intellectual disability is not common in A-T, disturbances in cerebellar as well as non-cerebellar brain areas and networks may result in cognitive deficits. Increased sensitivity to ionizing radiation (x-ray and gamma ray) can result in severe side effects from such treatments. Life expectancy is significantly reduced due to cancer, pulmonary disease, and infections. Variant A-T has a significantly milder disease course. While cerebellar ataxia can be absent, extrapyramidal movement disorders are common (typically dystonia and dystonic tremor) and most individuals have manifestations of axonal sensorimotor polyneuropathy. In contrast to classic A-T, immune function is generally normal, respiratory infections are not increased, and pulmonary disease is not a major feature. However, risk of developing malignancies is increased, particularly in premenopausal females who have an increased risk of developing breast cancer and hematologic malignancies.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/439">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_7317"><div><strong>Acute lymphoid leukemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7317</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0023449</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove">Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/7317">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_59797"><div><strong>Dubowitz syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>59797</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0175691</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Dubowitz syndrome (DS) is a rare multiple congenital syndrome characterized primarly by growth retardation, microcephaly, distinctive facial dysmorphism, cutaneous eczema, a mild to severe intellectual deficit and genital abnormalities.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/59797">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_339855"><div><strong>DNA ligase IV deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>339855</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1847827</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">LIG4 syndrome is an autosomal recessive severe combined immunodeficiency with features of radiosensitivity, chromosomal instability, pancytopenia, and developmental and growth delay. Leukemia and dysmorphic facial features have been reported in some patients (summary by van der Burg et al., 2006).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/339855">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_341214"><div><strong>CHIME syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>341214</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1848392</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">CHIME syndrome, also known as Zunich neuroectodermal syndrome, is an extremely rare autosomal recessive multisystem disorder clinically characterized by colobomas, congenital heart defects, migratory ichthyosiform dermatosis, mental retardation, and ear anomalies (CHIME). Other clinical features include distinctive facial features, abnormal growth, genitourinary abnormalities, seizures, and feeding difficulties (summary by Ng et al., 2012). The disorder is caused by a defect in glycosylphosphatidylinositol (GPI) biosynthesis. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/341214">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_344290"><div><strong>Noonan syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344290</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854469</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Noonan syndrome (NS) is characterized by characteristic facies, short stature, congenital heart defect, and developmental delay of variable degree. Other findings can include broad or webbed neck, unusual chest shape with superior pectus carinatum and inferior pectus excavatum, cryptorchidism, varied coagulation defects, lymphatic dysplasias, and ocular abnormalities. Although birth length is usually normal, final adult height approaches the lower limit of normal. Congenital heart disease occurs in 50%-80% of individuals. Pulmonary valve stenosis, often with dysplasia, is the most common heart defect and is found in 20%-50% of individuals. Hypertrophic cardiomyopathy, found in 20%-30% of individuals, may be present at birth or develop in infancy or childhood. Other structural defects include atrial and ventricular septal defects, branch pulmonary artery stenosis, and tetralogy of Fallot. Up to one fourth of affected individuals have mild intellectual disability, and language impairments in general are more common in NS than in the general population.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/344290">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_340879"><div><strong>Lymphoblastic leukemia, acute, with lymphomatous features</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>340879</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855472</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/340879">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_905078"><div><strong>Pancytopenia due to IKZF1 mutations</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>905078</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225173</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Common variable immunodeficiency-13 (CVID13) is an autosomal dominant primary immunodeficiency disorder characterized by recurrent bacterial infections, mainly affecting the respiratory tract, and associated with hypogammaglobulinemia and decreased numbers of B cells. The age at onset of clinical features can range from infancy to adulthood, and some patients may have a mild disorder or even remain clinically asymptomatic (summary by Kuehn et al., 2016). For a general description and a discussion of genetic heterogeneity of common variable immunodeficiency, see CVID1 (607594).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/905078">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1713491"><div><strong>Kostmann syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1713491</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5235141</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Severe congenital neutropenia-3 is an autosomal recessive bone marrow failure disorder characterized by low numbers of neutrophils, increased susceptibility to bacterial and fungal infections, and increased risk of developing myelodysplastic syndrome or acute myeloid leukemia. In addition, patients with HAX1 mutations affecting both isoform A and B of the gene develop neurologic abnormalities (summary by Boztug et al., 2010). The Swedish physician Rolf Kostmann (1956) described an autosomal recessive hematologic disorder, termed infantile agranulocytosis, with severe neutropenia with an absolute neutrophil count below 0.5 x 10(9)/l and early onset of severe bacterial infections. The disorder was later termed Kostmann syndrome (Skokowa et al., 2007). Lekstrom-Himes and Gallin (2000) discussed severe congenital neutropenia in a review of immunodeficiencies caused by defects in phagocytes. In addition to Kostmann agranulocytosis, recessively inherited neutropenic syndromes include congenital neutropenia with eosinophilia (257100), Chediak-Higashi syndrome (214500), and Fanconi pancytopenic syndrome (see 227650). For a phenotypic description and a discussion of genetic heterogeneity of severe congenital neutropenia, see SCN1 (202700).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1713491">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_7317" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acute lymphoid leukemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_439" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-telangiectasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_341214" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CHIME syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_339855" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">DNA ligase IV deficiency</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_59797" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dubowitz syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1713491" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kostmann syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_340879" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Lymphoblastic leukemia, acute, with lymphomatous features</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344290" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Noonan syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_905078" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pancytopenia due to IKZF1 mutations</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33049052">Diagnosis and treatment of mixed phenotype (T-myeloid/lymphoid) acute leukemia with novel ETV6-FGFR2 rearrangement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carll T,
|
||
Patel A,
|
||
Derman B,
|
||
Hyjek E,
|
||
Lager A,
|
||
Wanjari P,
|
||
Segal J,
|
||
Odenike O,
|
||
Fidai S,
|
||
Arber D</span><br />
|
||
<span class="medgenPMjournal">Blood Adv</span>
|
||
2020 Oct 13;4(19):4924-4928.
|
||
doi: 10.1182/bloodadvances.2019001282.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33049052" target="_blank">33049052</a><a href="/pmc/articles/PMC7556145" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26897718">Radioimmunotherapy for Treatment of Acute Leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bodet-Milin C,
|
||
Kraeber-Bodéré F,
|
||
Eugène T,
|
||
Guérard F,
|
||
Gaschet J,
|
||
Bailly C,
|
||
Mougin M,
|
||
Bourgeois M,
|
||
Faivre-Chauvet A,
|
||
Chérel M,
|
||
Chevallier P</span><br />
|
||
<span class="medgenPMjournal">Semin Nucl Med</span>
|
||
2016 Mar;46(2):135-46.
|
||
doi: 10.1053/j.semnuclmed.2015.10.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26897718" target="_blank">26897718</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3520409">Treatment of acute lymphoid leukemia in children: current regimens and future prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brecher ML</span><br />
|
||
<span class="medgenPMjournal">N Y State J Med</span>
|
||
1986 Apr;86(4):188-96.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3520409" target="_blank">3520409</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acute%20lymphoid%20leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (27)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/all.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Lymphoblastic Leukemia, 2024</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29985303">Systematic Review and Meta-Analysis of Selected Cancers in Petroleum Refinery Workers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schnatter AR,
|
||
Chen M,
|
||
DeVilbiss EA,
|
||
Lewis RJ,
|
||
Gallagher EM</span><br />
|
||
<span class="medgenPMjournal">J Occup Environ Med</span>
|
||
2018 Jul;60(7):e329-e342.
|
||
doi: 10.1097/JOM.0000000000001336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29985303" target="_blank">29985303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29605423">Treating Adult Acute Lymphoblastic Leukemia in Brazil-Increased Early Mortality Using a German Multicenter Acute Lymphoblastic Leukemia-based regimen.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fernandes da Silva Junior W,
|
||
Medina AB,
|
||
Yamakawa PE,
|
||
Buccheri V,
|
||
Velloso EDRP,
|
||
Rocha V</span><br />
|
||
<span class="medgenPMjournal">Clin Lymphoma Myeloma Leuk</span>
|
||
2018 Jun;18(6):e255-e259.
|
||
Epub 2018 Mar 14
|
||
doi: 10.1016/j.clml.2018.03.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29605423" target="_blank">29605423</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24577544">Endothelial health in childhood acute lymphoid leukemia survivors: pilot evaluation with peripheral artery tonometry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruble K,
|
||
Davis CL,
|
||
Han HR</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2015 Mar;37(2):117-20.
|
||
doi: 10.1097/MPH.0000000000000122.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24577544" target="_blank">24577544</a><a href="/pmc/articles/PMC4145053" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24319173">Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Relling MV,
|
||
Ramsey LB</span><br />
|
||
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
|
||
2013;2013:126-30.
|
||
doi: 10.1182/asheducation-2013.1.126.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24319173" target="_blank">24319173</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/54655">Letter: Immunotherapy for acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mathe G,
|
||
Schwarzenberg L,
|
||
De Vassal F,
|
||
Delgado M</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
1976 Jan 17;1(7951):143-4.
|
||
doi: 10.1016/s0140-6736(76)93179-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/54655" target="_blank">54655</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (271)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37897912">A GPX4 non-enzymatic domain and MDM2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Niu F,
|
||
Yang R,
|
||
Feng H,
|
||
Liu Y,
|
||
Liu R,
|
||
Ma B</span><br />
|
||
<span class="medgenPMjournal">Biochem Biophys Res Commun</span>
|
||
2023 Dec 3;684:149125.
|
||
Epub 2023 Oct 20
|
||
doi: 10.1016/j.bbrc.2023.149125.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37897912" target="_blank">37897912</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29394974">Proteomic Profile of Lymphoid Leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Almaiman AA</span><br />
|
||
<span class="medgenPMjournal">J Coll Physicians Surg Pak</span>
|
||
2018 Feb;28(2):133-145.
|
||
doi: 10.29271/jcpsp.2018.02.133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29394974" target="_blank">29394974</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24577544">Endothelial health in childhood acute lymphoid leukemia survivors: pilot evaluation with peripheral artery tonometry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruble K,
|
||
Davis CL,
|
||
Han HR</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2015 Mar;37(2):117-20.
|
||
doi: 10.1097/MPH.0000000000000122.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24577544" target="_blank">24577544</a><a href="/pmc/articles/PMC4145053" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6346242">Acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bleyer WA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
1983 Apr;12(4):277-92.
|
||
doi: 10.3928/0090-4481-19830401-02.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6346242" target="_blank">6346242</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/353669">Acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lusher JM,
|
||
Ravindranath Y</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
1978 Jul;7(7):466-82.
|
||
<span class="bold">PMID: </span><a href="/pubmed/353669" target="_blank">353669</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (257)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29394974">Proteomic Profile of Lymphoid Leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Almaiman AA</span><br />
|
||
<span class="medgenPMjournal">J Coll Physicians Surg Pak</span>
|
||
2018 Feb;28(2):133-145.
|
||
doi: 10.29271/jcpsp.2018.02.133.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29394974" target="_blank">29394974</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26337639">Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wu J,
|
||
Fu J,
|
||
Zhang M,
|
||
Liu D</span><br />
|
||
<span class="medgenPMjournal">J Hematol Oncol</span>
|
||
2015 Sep 4;8:104.
|
||
doi: 10.1186/s13045-015-0195-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26337639" target="_blank">26337639</a><a href="/pmc/articles/PMC4558758" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24319173">Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Relling MV,
|
||
Ramsey LB</span><br />
|
||
<span class="medgenPMjournal">Hematology Am Soc Hematol Educ Program</span>
|
||
2013;2013:126-30.
|
||
doi: 10.1182/asheducation-2013.1.126.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24319173" target="_blank">24319173</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21823028">JAK-mutant myeloproliferative neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Levine RL</span><br />
|
||
<span class="medgenPMjournal">Curr Top Microbiol Immunol</span>
|
||
2012;355:119-33.
|
||
doi: 10.1007/82_2011_170.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21823028" target="_blank">21823028</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/353669">Acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lusher JM,
|
||
Ravindranath Y</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
||
1978 Jul;7(7):466-82.
|
||
<span class="bold">PMID: </span><a href="/pubmed/353669" target="_blank">353669</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (198)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29985303">Systematic Review and Meta-Analysis of Selected Cancers in Petroleum Refinery Workers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schnatter AR,
|
||
Chen M,
|
||
DeVilbiss EA,
|
||
Lewis RJ,
|
||
Gallagher EM</span><br />
|
||
<span class="medgenPMjournal">J Occup Environ Med</span>
|
||
2018 Jul;60(7):e329-e342.
|
||
doi: 10.1097/JOM.0000000000001336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29985303" target="_blank">29985303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29605423">Treating Adult Acute Lymphoblastic Leukemia in Brazil-Increased Early Mortality Using a German Multicenter Acute Lymphoblastic Leukemia-based regimen.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fernandes da Silva Junior W,
|
||
Medina AB,
|
||
Yamakawa PE,
|
||
Buccheri V,
|
||
Velloso EDRP,
|
||
Rocha V</span><br />
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<span class="medgenPMjournal">Clin Lymphoma Myeloma Leuk</span>
|
||
2018 Jun;18(6):e255-e259.
|
||
Epub 2018 Mar 14
|
||
doi: 10.1016/j.clml.2018.03.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29605423" target="_blank">29605423</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24577544">Endothelial health in childhood acute lymphoid leukemia survivors: pilot evaluation with peripheral artery tonometry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ruble K,
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Davis CL,
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||
Han HR</span><br />
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<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
2015 Mar;37(2):117-20.
|
||
doi: 10.1097/MPH.0000000000000122.
|
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<span class="bold">PMID: </span><a href="/pubmed/24577544" target="_blank">24577544</a><a href="/pmc/articles/PMC4145053" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3520409">Treatment of acute lymphoid leukemia in children: current regimens and future prospects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brecher ML</span><br />
|
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<span class="medgenPMjournal">N Y State J Med</span>
|
||
1986 Apr;86(4):188-96.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3520409" target="_blank">3520409</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6346242">Acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bleyer WA</span><br />
|
||
<span class="medgenPMjournal">Pediatr Ann</span>
|
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1983 Apr;12(4):277-92.
|
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doi: 10.3928/0090-4481-19830401-02.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6346242" target="_blank">6346242</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (224)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38227176">The burden of acute lymphoid leukemia among adolescents and young adults in the Western Pacific Region: evidence from Global Burden Disease 2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang F,
|
||
Zhang B,
|
||
Lodder P,
|
||
Guo J</span><br />
|
||
<span class="medgenPMjournal">Cancer Causes Control</span>
|
||
2024 May;35(5):839-848.
|
||
Epub 2024 Jan 16
|
||
doi: 10.1007/s10552-023-01843-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38227176" target="_blank">38227176</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29985303">Systematic Review and Meta-Analysis of Selected Cancers in Petroleum Refinery Workers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schnatter AR,
|
||
Chen M,
|
||
DeVilbiss EA,
|
||
Lewis RJ,
|
||
Gallagher EM</span><br />
|
||
<span class="medgenPMjournal">J Occup Environ Med</span>
|
||
2018 Jul;60(7):e329-e342.
|
||
doi: 10.1097/JOM.0000000000001336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29985303" target="_blank">29985303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28645022">Benzene and childhood acute leukemia in Oklahoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Janitz AE,
|
||
Campbell JE,
|
||
Magzamen S,
|
||
Pate A,
|
||
Stoner JA,
|
||
Peck JD</span><br />
|
||
<span class="medgenPMjournal">Environ Res</span>
|
||
2017 Oct;158:167-173.
|
||
Epub 2017 Jun 20
|
||
doi: 10.1016/j.envres.2017.06.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28645022" target="_blank">28645022</a><a href="/pmc/articles/PMC5554454" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23773228">Novel agents and biomarkers for acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao Y,
|
||
Huang H,
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||
Wei G</span><br />
|
||
<span class="medgenPMjournal">J Hematol Oncol</span>
|
||
2013 Jun 18;6:40.
|
||
doi: 10.1186/1756-8722-6-40.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23773228" target="_blank">23773228</a><a href="/pmc/articles/PMC3718656" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23527958">Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grupp SA,
|
||
Kalos M,
|
||
Barrett D,
|
||
Aplenc R,
|
||
Porter DL,
|
||
Rheingold SR,
|
||
Teachey DT,
|
||
Chew A,
|
||
Hauck B,
|
||
Wright JF,
|
||
Milone MC,
|
||
Levine BL,
|
||
June CH</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2013 Apr 18;368(16):1509-1518.
|
||
Epub 2013 Mar 25
|
||
doi: 10.1056/NEJMoa1215134.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23527958" target="_blank">23527958</a><a href="/pmc/articles/PMC4058440" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (171)</a></div></div>
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|
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|
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/32720195">Assessment of Executive Functions after Treatment of Childhood Acute Lymphoid Leukemia: a Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Godoy PBG,
|
||
Simionato NM,
|
||
de Mello CB,
|
||
Suchecki D</span><br />
|
||
<span class="medgenPMjournal">Neuropsychol Rev</span>
|
||
2020 Sep;30(3):386-406.
|
||
Epub 2020 Jul 27
|
||
doi: 10.1007/s11065-020-09446-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32720195" target="_blank">32720195</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29985303">Systematic Review and Meta-Analysis of Selected Cancers in Petroleum Refinery Workers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schnatter AR,
|
||
Chen M,
|
||
DeVilbiss EA,
|
||
Lewis RJ,
|
||
Gallagher EM</span><br />
|
||
<span class="medgenPMjournal">J Occup Environ Med</span>
|
||
2018 Jul;60(7):e329-e342.
|
||
doi: 10.1097/JOM.0000000000001336.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29985303" target="_blank">29985303</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26324461">Health-related quality of life and symptom assessment in randomized controlled trials of patients with leukemia and myelodysplastic syndromes: What have we learned?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cannella L,
|
||
Caocci G,
|
||
Jacobs M,
|
||
Vignetti M,
|
||
Mandelli F,
|
||
Efficace F</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2015 Dec;96(3):542-54.
|
||
Epub 2015 Aug 1
|
||
doi: 10.1016/j.critrevonc.2015.07.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26324461" target="_blank">26324461</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Acute%20lymphoid%20leukemia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (71)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A3%5F23" target="_blank">FISH-interphase (32)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A3%5F32" target="_blank">Karyotyping (4)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&test_type=Research" target="_blank">Research (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (15)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (7)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (71)</a></li>
|
||
<li><a href="/gtr/tests?term=C0023449%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (57)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0023449%5bDISCUI%5d" target="_blank">See all (199)</a></total></li>
|
||
</ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=613065" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=513" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Acute%20lymphoid%20leukemia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22acute%20lymphoid%20leukemia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Acute%20lymphoid%20leukemia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/all.pdf">NCCN, 2024</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Acute Lymphoblastic Leukemia, 2024</div></li></ul></div>
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|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=114350%20136351%20139380%20151410%20186855%20187040%20600040%20602667" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=581[geneid]" target="_blank">View BAX variations in ClinVar</a></li><li><a href="/clinvar/?term=613[geneid]" target="_blank">View BCR variations in ClinVar</a></li><li><a href="/clinvar/?term=2322[geneid]" target="_blank">View FLT3 variations in ClinVar</a></li><li><a href="/clinvar/?term=2782[geneid]" target="_blank">View GNB1 variations in ClinVar</a></li><li><a href="/clinvar/?term=4683[geneid]" target="_blank">View NBN variations in ClinVar</a></li><li><a href="/clinvar/?term=6886[geneid]" target="_blank">View TAL1 variations in ClinVar</a></li><li><a href="/clinvar/?term=6887[geneid]" target="_blank">View TAL2 variations in ClinVar</a></li><li><a href="/clinvar/?term=8021[geneid]" target="_blank">View NUP214 variations in ClinVar</a></li><li><a href="/nuccore/160358346,210032225,219521903,237874277,300796208" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=613065" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Acute+Lymphoblastic+Leukemia/188" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/leukemia_acute_lymphoblastic" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Acute%20lymphoid%20leukemia" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/522/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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