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<meta name="keywords" content="C1301510, finding, moderate reduction in visual acuity, moderate vision loss, moderate visual impairment, moderate visual loss, moderately reduced visual acuity, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Moderate reduction of the ability to see. On the 6m visual acuity scale, moderate reduction is defined as less than 6/18 but at least 6/60. On the 20ft visual acuity scale, moderate reduction is defined as less than 20/70 but at least 20/200. On the decimal visual acuity scale, moderate reduction is defined as less than 0.3 but at least 0.1." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=723196
|
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ConceptID=C1301510
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Moderately reduced visual acuity</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>723196</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1301510</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Moderate reduction in visual acuity; Moderate vision loss; Moderate visual impairment; Moderate visual loss</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Moderate visual impairment (397542006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030515">HP:0030515</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Moderate reduction of the ability to see. On the 6m visual acuity scale, moderate reduction is defined as less than 6/18 but at least 6/60. On the 20ft visual acuity scale, moderate reduction is defined as less than 20/70 but at least 20/200. On the decimal visual acuity scale, moderate reduction is defined as less than 0.3 but at least 0.1. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1301510[DISCUI]&test_type=Clinical" ref="ncbi_uid=723196">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Moderately reduced visual acuity</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/108390" ref="tree=MeSH" title="MedGen record for Head and Neck Finding">Head and Neck Finding</a></span><ul><li><span class="TLline"><a href="/medgen/234247" ref="tree=MeSH" title="MedGen record for Eye and Ear Finding">Eye and Ear Finding</a></span><ul><li><span class="TLline"><a href="/medgen/662065" ref="tree=MeSH" title="MedGen record for Eye / vision finding">Eye / vision finding</a></span><ul><li><span class="TLline"><a href="/medgen/65889" ref="tree=MeSH" title="MedGen record for Reduced visual acuity">Reduced visual acuity</a></span><ul><li><span class="matched_ds">Moderately reduced visual acuity</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_340413"><div><strong>Achromatopsia 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>340413</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1849792</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Achromatopsia is characterized by reduced visual acuity, pendular nystagmus, increased sensitivity to light (photophobia), a small central scotoma, eccentric fixation, and reduced or complete loss of color discrimination. All individuals with achromatopsia (achromats) have impaired color discrimination along all three axes of color vision corresponding to the three cone classes: the protan or long-wavelength-sensitive cone axis (red), the deutan or middle-wavelength-sensitive cone axis (green), and the tritan or short-wavelength-sensitive cone axis (blue). Most individuals have complete achromatopsia, with total lack of function of all three types of cones. Rarely, individuals have incomplete achromatopsia, in which one or more cone types may be partially functioning. The manifestations are similar to those of individuals with complete achromatopsia, but generally less severe. Hyperopia is common in achromatopsia. Nystagmus develops during the first few weeks after birth followed by increased sensitivity to bright light. Best visual acuity varies with severity of the disease; it is 20/200 or less in complete achromatopsia and may be as high as 20/80 in incomplete achromatopsia. Visual acuity is usually stable over time; both nystagmus and sensitivity to bright light may improve slightly. Although the fundus is usually normal, macular changes (which may show early signs of progression) and vessel narrowing may be present in some affected individuals. Defects in the macula are visible on optical coherence tomography.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/340413">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_344245"><div><strong>Leber congenital amaurosis 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344245</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1854260</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Leber congenital amaurosis comprises a group of early-onset childhood retinal dystrophies characterized by vision loss, nystagmus, and severe retinal dysfunction. Patients usually present at birth with profound vision loss and pendular nystagmus. Electroretinogram (ERG) responses are usually nonrecordable. Other clinical findings may include high hypermetropia, photodysphoria, oculodigital sign, keratoconus, cataracts, and a variable appearance to the fundus (summary by Chung and Traboulsi, 2009). For a general description and a discussion of genetic heterogeneity of LCA, see 204000.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/344245">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_413025"><div><strong>Cone-rod dystrophy 13</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>413025</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2750720</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">There are more than 30 types of cone-rod dystrophy, which are distinguished by their genetic cause and their pattern of inheritance: autosomal recessive, autosomal dominant, and X-linked. Additionally, cone-rod dystrophy can occur alone without any other signs and symptoms or it can occur as part of a syndrome that affects multiple parts of the body.\n\nThe first signs and symptoms of cone-rod dystrophy, which often occur in childhood, are usually decreased sharpness of vision (visual acuity) and increased sensitivity to light (photophobia). These features are typically followed by impaired color vision (dyschromatopsia), blind spots (scotomas) in the center of the visual field, and partial side (peripheral) vision loss. Over time, affected individuals develop night blindness and a worsening of their peripheral vision, which can limit independent mobility. Decreasing visual acuity makes reading increasingly difficult and most affected individuals are legally blind by mid-adulthood. As the condition progresses, individuals may develop involuntary eye movements (nystagmus).\n\nCone-rod dystrophy is a group of related eye disorders that causes vision loss, which becomes more severe over time. These disorders affect the retina, which is the layer of light-sensitive tissue at the back of the eye. In people with cone-rod dystrophy, vision loss occurs as the light-sensing cells of the retina gradually deteriorate.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/413025">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_477139"><div><strong>Multiple congenital anomalies-hypotonia-seizures syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>477139</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3275508</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple congenital anomalies-hypotonia-seizures syndrome-2 (MCAHS2) is an X-linked recessive neurodevelopmental disorder characterized by dysmorphic features, neonatal hypotonia, early-onset myoclonic seizures, and variable congenital anomalies involving the central nervous, cardiac, and urinary systems. Some affected individuals die in infancy (summary by Johnston et al., 2012). The phenotype shows clinical variability with regard to severity and extraneurologic features. However, most patients present in infancy with early-onset epileptic encephalopathy associated with developmental arrest and subsequent severe neurologic disability; these features are consistent with a form of developmental and epileptic encephalopathy (DEE) (summary by Belet et al., 2014, Kato et al., 2014). The disorder is caused by a defect in glycosylphosphatidylinositol (GPI) biosynthesis. For a discussion of genetic heterogeneity of MCAHS, see MCAHS1 (614080). For a discussion of nomenclature and genetic heterogeneity of DEE, see 308350. For a discussion of genetic heterogeneity of GPI biosynthesis defects, see GPIBD1 (610293).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/477139">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863779"><div><strong>Vitelliform macular dystrophy 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863779</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015342</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Macular dystrophies are inherited retinal dystrophies in which various forms of deposits, pigmentary changes, and atrophic lesions are observed in the macula lutea, the cone-rich region of the central retina. Vitelliform macular dystrophies (VMDs) form a subset of macular dystrophies characterized by round yellow deposits, usually at the center of the macula and containing lipofuscin, a chemically heterogeneous pigment visualized by autofluorescence imaging of the fundus (summary by Manes et al., 2013). Vitelliform macular dystrophy-4 (VMD4) is characterized by late-onset moderate visual impairment, small satellite drusen-like lesions in the foveal area, preservation of retinal pigment epithelium (RPE) reflectivity, deposits above the RPE between the ellipsoid and outer segment interdigitation lines on spectral-domain optical coherence tomography (SD-OCT), and normal or borderline results on electrooculography (EOG) (Meunier et al., 2014). In most families with VMD4 caused by compound heterozygous or homozygous mutations in IMPG1, asymptomatic heterozygous carriers have been found to have fundus changes (Manes et al., 2013; Brandl et al., 2017). Brandl et al. (2017) examined patients with VMD4, caused by mutation in the IMPG1 gene, and patients with VMD5 (616152), caused by mutation in the IMPG2 gene, and observed strikingly similar phenotypic characteristics. They noted that retinal lesions progressed in consecutive stages, with the initial development of a single vitelliform lesion in the central macula, with detachment of the neurosensory retina and hyperreflective material located above a preserved Bruch membrane/RPE on SD-OCT. Next, resorption of the hyperreflective material occurs, leaving behind a dome-shaped, optically empty cavity; alternatively, the foveal cavity formed by retinal detachment may become successively filled with material. Finally, there is collapse of the cavity with central retinal atrophy and loss of RPE, resulting in the most pronounced loss of visual acuity. The authors also noted that symptoms tended to be more severe in patients with IMPG1 mutations. For a discussion of genetic heterogeneity of vitelliform macular dystrophy, see VMD1 (153840).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863779">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863780"><div><strong>Vitelliform macular dystrophy 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863780</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015343</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Macular dystrophies are inherited retinal dystrophies in which various forms of deposits, pigmentary changes, and atrophic lesions are observed in the macula lutea, the cone-rich region of the central retina. Vitelliform macular dystrophies (VMDs) form a subset of macular dystrophies characterized by round yellow deposits, usually at the center of the macula and containing lipofuscin, a chemically heterogeneous pigment visualized by autofluorescence imaging of the fundus (summary by Manes et al., 2013). Vitelliform macular dystrophy-5 (VMD5) is characterized by late-onset moderate visual impairment, preservation of retinal pigment epithelium (RPE) reflectivity, deposits above the RPE between the ellipsoid and outer segment interdigitation lines on spectral-domain optical coherence tomography (SD-OCT), and normal or borderline results on electrooculopathy (EOG) (Meunier et al., 2014). Brandl et al. (2017) examined patients with IMPG2- and IMPG1 (602870)-associated VMD (see VMD4; 616151) and observed strikingly similar phenotypic characteristics. They noted that retinal lesions progressed in consecutive stages, with the initial development of a single vitelliform lesion in the central macula, with detachment of the neurosensory retina and hyperreflective material located above the seemingly preserved Bruch membrane/RPE seen on SD-OCT. Next, resorption of the hyperreflective material occurs, leaving behind a dome-shaped, optically empty cavity; alternatively, the foveal cavity formed by retinal detachment may become successively filled with material. Finally, there is collapse of the cavity with central retinal atrophy and loss of RPE, resulting in the most pronounced loss of visual acuity. The authors also noted that symptoms tended to be more severe in patients with IMPG1 mutations. For a discussion of genetic heterogeneity of vitelliform macular dystrophy, see VMD1 (153840).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863780">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_340413" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Achromatopsia 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_413025" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cone-rod dystrophy 13</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344245" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leber congenital amaurosis 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_477139" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple congenital anomalies-hypotonia-seizures syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863779" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vitelliform macular dystrophy 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863780" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vitelliform macular dystrophy 5</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35356661">A systematic review of clinical practice guidelines for myopic macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen Y,
|
||
Han X,
|
||
Gordon I,
|
||
Safi S,
|
||
Lingham G,
|
||
Evans J,
|
||
Li J,
|
||
He M,
|
||
Keel S</span><br />
|
||
<span class="medgenPMjournal">J Glob Health</span>
|
||
2022;12:04026.
|
||
Epub 2022 Mar 26
|
||
doi: 10.7189/jogh.12.04026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35356661" target="_blank">35356661</a><a href="/pmc/articles/PMC8939288" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33993827">Does Age-Related Macular Degeneration (AMD) Treatment Influence Patient Falls and Mobility? A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garrigan H,
|
||
Hamati J,
|
||
Lalakia P,
|
||
Frasso R,
|
||
Salzman B,
|
||
Hyman L</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Epidemiol</span>
|
||
2022 Apr;29(2):128-138.
|
||
Epub 2021 May 17
|
||
doi: 10.1080/09286586.2021.1921227.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33993827" target="_blank">33993827</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32641797">Current perspectives in the management of keratoconus with contact lenses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lim L,
|
||
Lim EWL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2020 Dec;34(12):2175-2196.
|
||
Epub 2020 Jul 8
|
||
doi: 10.1038/s41433-020-1065-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32641797" target="_blank">32641797</a><a href="/pmc/articles/PMC7784906" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(moderately%20reduced%20visual%20acuity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (49)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34351414">Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brown DM,
|
||
Wykoff CC,
|
||
Boyer D,
|
||
Heier JS,
|
||
Clark WL,
|
||
Emanuelli A,
|
||
Higgins PM,
|
||
Singer M,
|
||
Weinreich DM,
|
||
Yancopoulos GD,
|
||
Berliner AJ,
|
||
Chu K,
|
||
Reed K,
|
||
Cheng Y,
|
||
Vitti R</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2021 Sep 1;139(9):946-955.
|
||
doi: 10.1001/jamaophthalmol.2021.2809.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34351414" target="_blank">34351414</a><a href="/pmc/articles/PMC8343518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275950">Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e130-e143.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30425-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275950" target="_blank">33275950</a><a href="/pmc/articles/PMC7820390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32641797">Current perspectives in the management of keratoconus with contact lenses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lim L,
|
||
Lim EWL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2020 Dec;34(12):2175-2196.
|
||
Epub 2020 Jul 8
|
||
doi: 10.1038/s41433-020-1065-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32641797" target="_blank">32641797</a><a href="/pmc/articles/PMC7784906" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12719068">Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wollensak G,
|
||
Spoerl E,
|
||
Seiler T</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2003 May;135(5):620-7.
|
||
doi: 10.1016/s0002-9394(02)02220-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12719068" target="_blank">12719068</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11594942">A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Age-Related Eye Disease Study Research Group</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2001 Oct;119(10):1417-36.
|
||
doi: 10.1001/archopht.119.10.1417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11594942" target="_blank">11594942</a><a href="/pmc/articles/PMC1462955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (639)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39128551">Progression Patterns and Risk Factors of Axial Elongation in Young Adults With Nonpathologic High Myopia: Three-Year Large Longitudinal Cohort Follow-Up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kong K,
|
||
Jiang J,
|
||
Wang P,
|
||
Song Y,
|
||
Lin F,
|
||
Li F,
|
||
Gao X,
|
||
Liu X,
|
||
Jin L,
|
||
Wang Z,
|
||
Liu Y,
|
||
Chen M,
|
||
Ohno-Matsui K,
|
||
Jonas JB,
|
||
Chen S,
|
||
Zhang X;
|
||
GLAUCOMA SUSPECTS WITH HIGH MYOPIA STUDY GROUP</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2024 Nov;267:293-303.
|
||
Epub 2024 Aug 14
|
||
doi: 10.1016/j.ajo.2024.08.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39128551" target="_blank">39128551</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37593770">Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh S,
|
||
Keller PR,
|
||
Busija L,
|
||
McMillan P,
|
||
Makrai E,
|
||
Lawrenson JG,
|
||
Hull CC,
|
||
Downie LE</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Aug 18;8(8):CD013244.
|
||
doi: 10.1002/14651858.CD013244.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37593770" target="_blank">37593770</a><a href="/pmc/articles/PMC10436683" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34351414">Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brown DM,
|
||
Wykoff CC,
|
||
Boyer D,
|
||
Heier JS,
|
||
Clark WL,
|
||
Emanuelli A,
|
||
Higgins PM,
|
||
Singer M,
|
||
Weinreich DM,
|
||
Yancopoulos GD,
|
||
Berliner AJ,
|
||
Chu K,
|
||
Reed K,
|
||
Cheng Y,
|
||
Vitti R</span><br />
|
||
<span class="medgenPMjournal">JAMA Ophthalmol</span>
|
||
2021 Sep 1;139(9):946-955.
|
||
doi: 10.1001/jamaophthalmol.2021.2809.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34351414" target="_blank">34351414</a><a href="/pmc/articles/PMC8343518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12049574">The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kass MA,
|
||
Heuer DK,
|
||
Higginbotham EJ,
|
||
Johnson CA,
|
||
Keltner JL,
|
||
Miller JP,
|
||
Parrish RK 2nd,
|
||
Wilson MR,
|
||
Gordon MO</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2002 Jun;120(6):701-13; discussion 829-30.
|
||
doi: 10.1001/archopht.120.6.701.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12049574" target="_blank">12049574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10571351">Early Manifest Glaucoma Trial: design and baseline data.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leske MC,
|
||
Heijl A,
|
||
Hyman L,
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Bengtsson B</span><br />
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<span class="medgenPMjournal">Ophthalmology</span>
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1999 Nov;106(11):2144-53.
|
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doi: 10.1016/s0161-6420(99)90497-9.
|
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<span class="bold">PMID: </span><a href="/pubmed/10571351" target="_blank">10571351</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (355)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37593770">Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Singh S,
|
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Keller PR,
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Busija L,
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McMillan P,
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Makrai E,
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Lawrenson JG,
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Hull CC,
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Downie LE</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2023 Aug 18;8(8):CD013244.
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doi: 10.1002/14651858.CD013244.pub2.
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||
<span class="bold">PMID: </span><a href="/pubmed/37593770" target="_blank">37593770</a><a href="/pmc/articles/PMC10436683" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37585677">Hyperbaric oxygen therapy for late radiation tissue injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin ZC,
|
||
Bennett MH,
|
||
Hawkins GC,
|
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Azzopardi CP,
|
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Feldmeier J,
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Smee R,
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Milross C</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2023 Aug 15;8(8):CD005005.
|
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doi: 10.1002/14651858.CD005005.pub5.
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<span class="bold">PMID: </span><a href="/pubmed/37585677" target="_blank">37585677</a><a href="/pmc/articles/PMC10426260" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34351414">Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From the PANORAMA Randomized Clinical Trial.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Brown DM,
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Wykoff CC,
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Boyer D,
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Heier JS,
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Clark WL,
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Emanuelli A,
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Higgins PM,
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Singer M,
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Weinreich DM,
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Yancopoulos GD,
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Berliner AJ,
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Chu K,
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Reed K,
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Cheng Y,
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Vitti R</span><br />
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<span class="medgenPMjournal">JAMA Ophthalmol</span>
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2021 Sep 1;139(9):946-955.
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doi: 10.1001/jamaophthalmol.2021.2809.
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<span class="bold">PMID: </span><a href="/pubmed/34351414" target="_blank">34351414</a><a href="/pmc/articles/PMC8343518" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/12719068">Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wollensak G,
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Spoerl E,
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Seiler T</span><br />
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<span class="medgenPMjournal">Am J Ophthalmol</span>
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2003 May;135(5):620-7.
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doi: 10.1016/s0002-9394(02)02220-1.
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||
<span class="bold">PMID: </span><a href="/pubmed/12719068" target="_blank">12719068</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11594942">A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Age-Related Eye Disease Study Research Group</span><br />
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<span class="medgenPMjournal">Arch Ophthalmol</span>
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2001 Oct;119(10):1417-36.
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doi: 10.1001/archopht.119.10.1417.
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<span class="bold">PMID: </span><a href="/pubmed/11594942" target="_blank">11594942</a><a href="/pmc/articles/PMC1462955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (420)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39128551">Progression Patterns and Risk Factors of Axial Elongation in Young Adults With Nonpathologic High Myopia: Three-Year Large Longitudinal Cohort Follow-Up.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kong K,
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Jiang J,
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Wang P,
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Song Y,
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Lin F,
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||
Li F,
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Gao X,
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||
Liu X,
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Jin L,
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||
Wang Z,
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||
Liu Y,
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||
Chen M,
|
||
Ohno-Matsui K,
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||
Jonas JB,
|
||
Chen S,
|
||
Zhang X;
|
||
GLAUCOMA SUSPECTS WITH HIGH MYOPIA STUDY GROUP</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2024 Nov;267:293-303.
|
||
Epub 2024 Aug 14
|
||
doi: 10.1016/j.ajo.2024.08.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39128551" target="_blank">39128551</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275950">Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e130-e143.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30425-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275950" target="_blank">33275950</a><a href="/pmc/articles/PMC7820390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12049574">The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kass MA,
|
||
Heuer DK,
|
||
Higginbotham EJ,
|
||
Johnson CA,
|
||
Keltner JL,
|
||
Miller JP,
|
||
Parrish RK 2nd,
|
||
Wilson MR,
|
||
Gordon MO</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2002 Jun;120(6):701-13; discussion 829-30.
|
||
doi: 10.1001/archopht.120.6.701.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12049574" target="_blank">12049574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11594942">A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Age-Related Eye Disease Study Research Group</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2001 Oct;119(10):1417-36.
|
||
doi: 10.1001/archopht.119.10.1417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11594942" target="_blank">11594942</a><a href="/pmc/articles/PMC1462955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2062512">Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study Research Group.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Ophthalmology</span>
|
||
1991 May;98(5 Suppl):766-85.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2062512" target="_blank">2062512</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (282)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37593770">Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh S,
|
||
Keller PR,
|
||
Busija L,
|
||
McMillan P,
|
||
Makrai E,
|
||
Lawrenson JG,
|
||
Hull CC,
|
||
Downie LE</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Aug 18;8(8):CD013244.
|
||
doi: 10.1002/14651858.CD013244.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37593770" target="_blank">37593770</a><a href="/pmc/articles/PMC10436683" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37585677">Hyperbaric oxygen therapy for late radiation tissue injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin ZC,
|
||
Bennett MH,
|
||
Hawkins GC,
|
||
Azzopardi CP,
|
||
Feldmeier J,
|
||
Smee R,
|
||
Milross C</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Aug 15;8(8):CD005005.
|
||
doi: 10.1002/14651858.CD005005.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37585677" target="_blank">37585677</a><a href="/pmc/articles/PMC10426260" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275950">Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e130-e143.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30425-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275950" target="_blank">33275950</a><a href="/pmc/articles/PMC7820390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12049574">The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kass MA,
|
||
Heuer DK,
|
||
Higginbotham EJ,
|
||
Johnson CA,
|
||
Keltner JL,
|
||
Miller JP,
|
||
Parrish RK 2nd,
|
||
Wilson MR,
|
||
Gordon MO</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2002 Jun;120(6):701-13; discussion 829-30.
|
||
doi: 10.1001/archopht.120.6.701.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12049574" target="_blank">12049574</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11594942">A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Age-Related Eye Disease Study Research Group</span><br />
|
||
<span class="medgenPMjournal">Arch Ophthalmol</span>
|
||
2001 Oct;119(10):1417-36.
|
||
doi: 10.1001/archopht.119.10.1417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11594942" target="_blank">11594942</a><a href="/pmc/articles/PMC1462955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (356)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38275741">Anti-vascular endothelial growth factor for diabetic macular oedema: a network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Virgili G,
|
||
Curran K,
|
||
Lucenteforte E,
|
||
Peto T,
|
||
Parravano M</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Jun 27;2023(6):CD007419.
|
||
doi: 10.1002/14651858.CD007419.pub7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38275741" target="_blank">38275741</a><a href="/pmc/articles/PMC10294542" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37702300">Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Evans JR,
|
||
Lawrenson JG</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Sep 13;9(9):CD000254.
|
||
doi: 10.1002/14651858.CD000254.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37702300" target="_blank">37702300</a><a href="/pmc/articles/PMC10498493" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37593770">Blue-light filtering spectacle lenses for visual performance, sleep, and macular health in adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh S,
|
||
Keller PR,
|
||
Busija L,
|
||
McMillan P,
|
||
Makrai E,
|
||
Lawrenson JG,
|
||
Hull CC,
|
||
Downie LE</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Aug 18;8(8):CD013244.
|
||
doi: 10.1002/14651858.CD013244.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37593770" target="_blank">37593770</a><a href="/pmc/articles/PMC10436683" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37585677">Hyperbaric oxygen therapy for late radiation tissue injury.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lin ZC,
|
||
Bennett MH,
|
||
Hawkins GC,
|
||
Azzopardi CP,
|
||
Feldmeier J,
|
||
Smee R,
|
||
Milross C</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2023 Aug 15;8(8):CD005005.
|
||
doi: 10.1002/14651858.CD005005.pub5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37585677" target="_blank">37585677</a><a href="/pmc/articles/PMC10426260" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33275950">Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">GBD 2019 Blindness and Vision Impairment Collaborators;
|
||
Vision Loss Expert Group of the Global Burden of Disease Study</span><br />
|
||
<span class="medgenPMjournal">Lancet Glob Health</span>
|
||
2021 Feb;9(2):e130-e143.
|
||
Epub 2020 Dec 1
|
||
doi: 10.1016/S2214-109X(20)30425-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33275950" target="_blank">33275950</a><a href="/pmc/articles/PMC7820390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moderately%20reduced%20visual%20acuity%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (72)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1301510%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C1301510%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1301510%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Moderately%20reduced%20visual%20acuity" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(moderately%20reduced%20visual%20acuity)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Moderately%20reduced%20visual%20acuity%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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