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<!--
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||
UID=69129
|
||
ConceptID=C0241011
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased serum estradiol</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>69129</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0241011</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Low serum 17-B-estradiol levels; Low serum estradiol levels; Serum estradiol levels below reference range</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Low serum estradiol levels (166449002); Low serum 17-B-estradiol levels (166449002); Serum estradiol levels below reference range (166449002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008214">HP:0008214</a></td></tr>
|
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">A reduction below normal concentration of estradiol in the circulation. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased serum estradiol</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/893021" ref="tree=MeSH" title="MedGen record for Abnormality of the endocrine system">Abnormality of the endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/871176" ref="tree=MeSH" title="MedGen record for Abnormal circulating hormone concentration">Abnormal circulating hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/1779099" ref="tree=MeSH" title="MedGen record for Abnormal circulating sex hormone concentration">Abnormal circulating sex hormone concentration</a></span><ul><li><span class="TLline"><a href="/medgen/1369064" ref="tree=MeSH" title="MedGen record for Abnormal circulating estrogen level">Abnormal circulating estrogen level</a></span><ul><li><span class="TLline"><a href="/medgen/910028" ref="tree=MeSH" title="MedGen record for Abnormal serum estradiol">Abnormal serum estradiol</a></span><ul><li><span class="matched_ds">Decreased serum estradiol</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_347328"><div><strong>Hypogonadotropic hypogonadism 12 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347328</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1856897</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347328">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_346973"><div><strong>Congenital cataracts-facial dysmorphism-neuropathy syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346973</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858726</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">CTDP1-related congenital cataracts, facial dysmorphism, and neuropathy (CTDP1-CCFDN) is characterized by abnormalities of the eye (bilateral congenital cataracts, microcornea, microphthalmia, micropupils), mildly dysmorphic facial features apparent in late childhood, and a hypo-/demyelinating, symmetric, distal peripheral neuropathy. The neuropathy is predominantly motor at the onset and results in delays in early motor development, progressing to severe disability by the third decade of life. Secondary foot deformities and scoliosis are common. Sensory neuropathy develops after age ten years. Most affected individuals have a mild nonprogressive intellectual deficit and cerebellar involvement including ataxia, nystagmus, intention tremor, and dysmetria. All have short stature and most have subnormal weight. Adults have hypogonadotropic hypogonadism. Parainfectious rhabdomyolysis (profound muscle weakness, myoglobinuria, and excessively elevated serum concentration of creatine kinase usually following a viral infection) is a potentially life-threatening complication. To date all affected individuals and carriers identified have been from the Romani population.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/346973">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_762090"><div><strong>Hypogonadotropic hypogonadism 13 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762090</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3541462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/762090">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_766935"><div><strong>Hypogonadotropic hypogonadism 16 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766935</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554021</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/766935">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815435"><div><strong>Perrault syndrome 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815435</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809105</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Perrault syndrome is characterized by sensorineural hearing loss (SNHL) in males and females and ovarian dysfunction in females. SNHL is bilateral and ranges from profound with prelingual (congenital) onset to moderate with early-childhood onset. When onset is in early childhood, hearing loss can be progressive. Ovarian dysfunction ranges from gonadal dysgenesis (absent or streak gonads) manifesting as primary amenorrhea to primary ovarian insufficiency (POI) defined as cessation of menses before age 40 years. Fertility in affected males is reported as normal (although the number of reported males is limited). Neurologic features described in some individuals with Perrault syndrome include learning difficulties and developmental delay, cerebellar ataxia, and motor and sensory peripheral neuropathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815435">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816697"><div><strong>Premature ovarian failure 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816697</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3810367</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure (POF), the endpoint of primary ovarian insufficiency, affects approximately 1% of women worldwide. Patients with POF present with at least a 6-month history of amenorrhea and elevated plasma levels of follicle-stimulating hormone (more than 40 mIU per milliliter). The disorder can result from premature depletion of the follicle pool, follicular atresia, follicle growth arrest, or ovarian dysgenesis (see 233300). In approximately 10 to 15% of patients with POF, a genetic cause has been determined (summary by Caburet et al., 2014). For general phenotypic information and a discussion of genetic heterogeneity of premature ovarian failure, see POF1 (311360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/816697">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863425"><div><strong>Hypogonadotropic hypogonadism 22 with or without anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863425</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014988</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863425">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863846"><div><strong>46,XX ovarian dysgenesis-short stature syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863846</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015409</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare genetic disorder of sex development characterized by primary amenorrhea, short stature, delayed bone age, decreased levels of estradiol, elevated levels of follicle-stimulating hormone and luteinizing hormone, absent or underdeveloped uterus and ovaries, delayed development of pubic and axillary hair and normal 46,XX karyotype.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863846">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1627972"><div><strong>Ovarian dysgenesis 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1627972</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540141</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1627972">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1646133"><div><strong>Premature ovarian failure 14</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1646133</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4693941</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure-14 (POF14) is characterized by amenorrhea, hypoestrogenism, and elevated gonadotropin levels (Franca et al., 2018). For a general phenotypic description and discussion of genetic heterogeneity of premature ovarian failure, see POF1 (311360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1646133">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648458"><div><strong>Ovarian dysgenesis 7</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748263</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-7 (ODG7) is characterized by primary amenorrhea, delayed puberty, elevated gonadotropic hormones, and small uterus and ovaries. Ovarian histology shows fibrotic ovaries without follicles (Chen et al., 2018). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648458">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648455"><div><strong>Ovarian dysgenesis 8</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648455</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4748626</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-8 (ODG8) is characterized by complete lack of estrogen action, resulting in absent breast development, primary amenorrhea, and osteoporosis (Lang-Muritano et al., 2018). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648455">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1684679"><div><strong>Premature ovarian failure 16</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684679</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231474</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure-16 (POF16) is characterized by onset of amenorrhea early in the fourth decade of life, accompanied by elevated follicle-stimulating hormone (FSH; see 136530) levels and low estradiol levels. Ovaries are smaller than normal and show a solid echo pattern with no antral follicle (Zhang et al., 2018).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1684679">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1717461"><div><strong>Hypogonadotropic hypogonadism 25 with anosmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1717461</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5394246</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hypogonadotropic hypogonadism-25 with anosmia (HH25) is characterized by delayed or absent puberty with low gonadotropic hormones in the setting of low testosterone or estradiol. Affected individuals also exhibit hyposmia or anosmia, with hypoplastic olfactory bulbs on MRI. Intrafamilial variable expressivity and incomplete penetrance has been observed (Messina et al., 2020). For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia, see 147950.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1717461">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1748767"><div><strong>Premature ovarian failure 17</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1748767</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5436889</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure-17 (POF17) is characterized by early cessation of menses after initial menarche, with small ovaries and uterus (Zhang et al., 2019). For a discussion of genetic heterogeneity of premature ovarian failure, see POF1 (311360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1748767">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794256"><div><strong>Ovarian dysgenesis 9</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794256</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562046</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-9 (ODG9) is characterized by severe nonsyndromic primary ovarian insufficiency with primary amenorrhea, hypoplastic or absent ovaries, and delayed bone age. Patient cells show evidence of chromosomal instability (Smirin-Yosef et al., 2017; Heddar et al., 2022). For a general phenotypic description and discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794256">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1801078"><div><strong>Ovarian dysgenesis 10</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1801078</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676966</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-10 (ODG10) is characterized by primary amenorrhea and absent puberty. The uterus is small and prepubertal, and ovaries are streak or not visualized on ultrasound (McGlacken-Byrne et al., 2022). Mutation in the ZSWIM7 gene also causes male infertility due to spermatogenic failure (SPGF71; 619831). For a general phenotypic description and discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1801078">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1841035"><div><strong>Premature ovarian failure 21</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1841035</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5830399</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure-21 (POF21) is characterized by female infertility due to primary or secondary amenorrhea. Ovaries are small, atrophic, or nonvisualized on ultrasound (Tucker et al., 2019; Tucker et al., 2022). For a general phenotypic description and a discussion of genetic heterogeneity of POF, see POF1 (311360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1841035">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1858807"><div><strong>Premature ovarian failure 24</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1858807</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935624</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Premature ovarian failure-24 (POF24) is characterized by the development of secondary amenorrhea in the fourth decade of life, with a dearth of antral follicles detected on ultrasound. Patients may experience subfertility or infertility (He et al., 2021). For a general phenotypic description and discussion of genetic heterogeneity of premature ovarian failure, see POF1 (311360).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1858807">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1856331"><div><strong>Ovarian dysgenesis 11</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1856331</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935637</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Ovarian dysgenesis-11 (ODG11) is characterized by primary amenorrhea and delayed puberty, with absent ovaries on pelvic ultrasound (Tucker et al., 2022; Wu et al., 2023). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1856331">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863846" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">46,XX ovarian dysgenesis-short stature syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346973" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital cataracts-facial dysmorphism-neuropathy syndrome</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347328" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 12 with or without anosmia</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762090" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 13 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_766935" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 16 with or without anosmia</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (20)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863425" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 22 with or without anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1717461" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadotropic hypogonadism 25 with anosmia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1801078" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 10</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1856331" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 11</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1627972" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648458" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 7</a></div>
|
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648455" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 8</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794256" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ovarian dysgenesis 9</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815435" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Perrault syndrome 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1646133" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 14</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684679" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 16</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1748767" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 17</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1841035" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 21</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1858807" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 24</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816697" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Premature ovarian failure 8</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38049593">Human Bone Marrow Derived-Mesenchymal Stem Cells Treatment for Autoimmune Premature Ovarian Insufficiency.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ma WQ,
|
||
Zhuo AP,
|
||
Xiao YL,
|
||
Gao M,
|
||
Yang YT,
|
||
Tang LC,
|
||
Wu YH,
|
||
Tian D,
|
||
Fu XF</span><br />
|
||
<span class="medgenPMjournal">Stem Cell Rev Rep</span>
|
||
2024 Feb;20(2):538-553.
|
||
Epub 2023 Dec 4
|
||
doi: 10.1007/s12015-023-10629-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38049593" target="_blank">38049593</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27203299">Strategies for the management of OHSS: Results from freezing-all cycles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Borges E Jr,
|
||
Braga DP,
|
||
Setti AS,
|
||
Vingris LS,
|
||
Figueira RC,
|
||
Iaconelli A Jr</span><br />
|
||
<span class="medgenPMjournal">JBRA Assist Reprod</span>
|
||
2016 Mar 1;20(1):8-12.
|
||
doi: 10.5935/1518-0557.20160003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27203299" target="_blank">27203299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20581783">Estrogen analogues: promising target for prevention and treatment of esophageal squamous cell carcinoma in high risk areas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang QM,
|
||
Yuan L,
|
||
Qi YJ,
|
||
Ma ZY,
|
||
Wang LD</span><br />
|
||
<span class="medgenPMjournal">Med Sci Monit</span>
|
||
2010 Jul;16(7):HY19-22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20581783" target="_blank">20581783</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22decreased%20serum%20estradiol%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (6)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432835">Estradiol (E (2)) Reduction Adversely Affect the Embryo Quality and Clinical Outcomes of In Vitro Fertilization and Embryo transfer (IVF-ET).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng J,
|
||
Yang S,
|
||
Ma H,
|
||
Liang Y,
|
||
Zhao J</span><br />
|
||
<span class="medgenPMjournal">J Healthc Eng</span>
|
||
2022;2022:2473876.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1155/2022/2473876.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432835" target="_blank">35432835</a><a href="/pmc/articles/PMC9010151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27203299">Strategies for the management of OHSS: Results from freezing-all cycles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Borges E Jr,
|
||
Braga DP,
|
||
Setti AS,
|
||
Vingris LS,
|
||
Figueira RC,
|
||
Iaconelli A Jr</span><br />
|
||
<span class="medgenPMjournal">JBRA Assist Reprod</span>
|
||
2016 Mar 1;20(1):8-12.
|
||
doi: 10.5935/1518-0557.20160003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27203299" target="_blank">27203299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15552228">Osteoporosis: gender-specific aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pietschmann P,
|
||
Kerschan-Schindl K</span><br />
|
||
<span class="medgenPMjournal">Wien Med Wochenschr</span>
|
||
2004 Sep;154(17-18):411-5.
|
||
doi: 10.1007/s10354-004-0100-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15552228" target="_blank">15552228</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9457744">Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagata C,
|
||
Kabuto M,
|
||
Kurisu Y,
|
||
Shimizu H</span><br />
|
||
<span class="medgenPMjournal">Nutr Cancer</span>
|
||
1997;29(3):228-33.
|
||
doi: 10.1080/01635589709514629.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9457744" target="_blank">9457744</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7555984">Menstrual disorders in women with epilepsy receiving carbamazepine.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Isojärvi JI,
|
||
Laatikainen TJ,
|
||
Pakarinen AJ,
|
||
Juntunen KT,
|
||
Myllylä VV</span><br />
|
||
<span class="medgenPMjournal">Epilepsia</span>
|
||
1995 Jul;36(7):676-81.
|
||
doi: 10.1111/j.1528-1157.1995.tb01045.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7555984" target="_blank">7555984</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20serum%20estradiol%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432835">Estradiol (E (2)) Reduction Adversely Affect the Embryo Quality and Clinical Outcomes of In Vitro Fertilization and Embryo transfer (IVF-ET).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng J,
|
||
Yang S,
|
||
Ma H,
|
||
Liang Y,
|
||
Zhao J</span><br />
|
||
<span class="medgenPMjournal">J Healthc Eng</span>
|
||
2022;2022:2473876.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1155/2022/2473876.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432835" target="_blank">35432835</a><a href="/pmc/articles/PMC9010151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31680156">Maternal Testosterone Excess Contributes to Reproductive System Dysfunction of Female Offspring Mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
||
Zhang A,
|
||
Gong M,
|
||
Lu Y,
|
||
Zhao C,
|
||
Shen X,
|
||
Zhang X,
|
||
Wang L,
|
||
Chen J,
|
||
Ju R</span><br />
|
||
<span class="medgenPMjournal">Endocrinology</span>
|
||
2020 May 1;161(5)
|
||
doi: 10.1210/endocr/bqz011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31680156" target="_blank">31680156</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26585670">Recurrent endometrial hyperplasia as a presentation of estrogen-secreting thecoma - case report and minireview of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Podfigurna-Stopa A,
|
||
Czyzyk A,
|
||
Katulski K,
|
||
Moszynski R,
|
||
Sajdak S,
|
||
Genazzani AR,
|
||
Meczekalski B</span><br />
|
||
<span class="medgenPMjournal">Gynecol Endocrinol</span>
|
||
2016;32(3):184-7.
|
||
Epub 2015 Nov 20
|
||
doi: 10.3109/09513590.2015.1113519.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26585670" target="_blank">26585670</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9215184">Vaginal pH as a marker for bacterial pathogens and menopausal status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caillouette JC,
|
||
Sharp CF Jr,
|
||
Zimmerman GJ,
|
||
Roy S</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
1997 Jun;176(6):1270-5; discussion 1275-7.
|
||
doi: 10.1016/s0002-9378(97)70345-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9215184" target="_blank">9215184</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7260784">Estradiol receptor levels in human breast carcinomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bird CE,
|
||
Houghton B,
|
||
Westenbrink W,
|
||
Tenniswood M,
|
||
Sterns EE,
|
||
Clark AF</span><br />
|
||
<span class="medgenPMjournal">Can Med Assoc J</span>
|
||
1981 Apr 15;124(8):1010-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7260784" target="_blank">7260784</a><a href="/pmc/articles/PMC1705380" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20serum%20estradiol%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27203299">Strategies for the management of OHSS: Results from freezing-all cycles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Borges E Jr,
|
||
Braga DP,
|
||
Setti AS,
|
||
Vingris LS,
|
||
Figueira RC,
|
||
Iaconelli A Jr</span><br />
|
||
<span class="medgenPMjournal">JBRA Assist Reprod</span>
|
||
2016 Mar 1;20(1):8-12.
|
||
doi: 10.5935/1518-0557.20160003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27203299" target="_blank">27203299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21098873">Effects of curcumin on the skeletal system in rats.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Folwarczna J,
|
||
Zych M,
|
||
Trzeciak HI</span><br />
|
||
<span class="medgenPMjournal">Pharmacol Rep</span>
|
||
2010 Sep-Oct;62(5):900-9.
|
||
doi: 10.1016/s1734-1140(10)70350-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21098873" target="_blank">21098873</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15552228">Osteoporosis: gender-specific aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pietschmann P,
|
||
Kerschan-Schindl K</span><br />
|
||
<span class="medgenPMjournal">Wien Med Wochenschr</span>
|
||
2004 Sep;154(17-18):411-5.
|
||
doi: 10.1007/s10354-004-0100-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15552228" target="_blank">15552228</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9457744">Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nagata C,
|
||
Kabuto M,
|
||
Kurisu Y,
|
||
Shimizu H</span><br />
|
||
<span class="medgenPMjournal">Nutr Cancer</span>
|
||
1997;29(3):228-33.
|
||
doi: 10.1080/01635589709514629.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9457744" target="_blank">9457744</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2956416">Role of nutrition in managing the premenstrual tension syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abraham GE,
|
||
Rumley RE</span><br />
|
||
<span class="medgenPMjournal">J Reprod Med</span>
|
||
1987 Jun;32(6):405-22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2956416" target="_blank">2956416</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20serum%20estradiol%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432835">Estradiol (E (2)) Reduction Adversely Affect the Embryo Quality and Clinical Outcomes of In Vitro Fertilization and Embryo transfer (IVF-ET).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng J,
|
||
Yang S,
|
||
Ma H,
|
||
Liang Y,
|
||
Zhao J</span><br />
|
||
<span class="medgenPMjournal">J Healthc Eng</span>
|
||
2022;2022:2473876.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1155/2022/2473876.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432835" target="_blank">35432835</a><a href="/pmc/articles/PMC9010151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20581783">Estrogen analogues: promising target for prevention and treatment of esophageal squamous cell carcinoma in high risk areas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang QM,
|
||
Yuan L,
|
||
Qi YJ,
|
||
Ma ZY,
|
||
Wang LD</span><br />
|
||
<span class="medgenPMjournal">Med Sci Monit</span>
|
||
2010 Jul;16(7):HY19-22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20581783" target="_blank">20581783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14507819">GnRH antagonists followed by a decline in serum estradiol results in adverse outcomes in donor oocyte cycles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lindheim SR,
|
||
Morales AJ</span><br />
|
||
<span class="medgenPMjournal">Hum Reprod</span>
|
||
2003 Oct;18(10):2048-51.
|
||
doi: 10.1093/humrep/deg407.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14507819" target="_blank">14507819</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9215184">Vaginal pH as a marker for bacterial pathogens and menopausal status.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Caillouette JC,
|
||
Sharp CF Jr,
|
||
Zimmerman GJ,
|
||
Roy S</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
1997 Jun;176(6):1270-5; discussion 1275-7.
|
||
doi: 10.1016/s0002-9378(97)70345-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9215184" target="_blank">9215184</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20serum%20estradiol%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35432835">Estradiol (E (2)) Reduction Adversely Affect the Embryo Quality and Clinical Outcomes of In Vitro Fertilization and Embryo transfer (IVF-ET).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cheng J,
|
||
Yang S,
|
||
Ma H,
|
||
Liang Y,
|
||
Zhao J</span><br />
|
||
<span class="medgenPMjournal">J Healthc Eng</span>
|
||
2022;2022:2473876.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1155/2022/2473876.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35432835" target="_blank">35432835</a><a href="/pmc/articles/PMC9010151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31680156">Maternal Testosterone Excess Contributes to Reproductive System Dysfunction of Female Offspring Mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
||
Zhang A,
|
||
Gong M,
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||
Lu Y,
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Zhao C,
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||
Shen X,
|
||
Zhang X,
|
||
Wang L,
|
||
Chen J,
|
||
Ju R</span><br />
|
||
<span class="medgenPMjournal">Endocrinology</span>
|
||
2020 May 1;161(5)
|
||
doi: 10.1210/endocr/bqz011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31680156" target="_blank">31680156</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27203299">Strategies for the management of OHSS: Results from freezing-all cycles.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Borges E Jr,
|
||
Braga DP,
|
||
Setti AS,
|
||
Vingris LS,
|
||
Figueira RC,
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Iaconelli A Jr</span><br />
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<span class="medgenPMjournal">JBRA Assist Reprod</span>
|
||
2016 Mar 1;20(1):8-12.
|
||
doi: 10.5935/1518-0557.20160003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27203299" target="_blank">27203299</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15552228">Osteoporosis: gender-specific aspects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pietschmann P,
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Kerschan-Schindl K</span><br />
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<span class="medgenPMjournal">Wien Med Wochenschr</span>
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2004 Sep;154(17-18):411-5.
|
||
doi: 10.1007/s10354-004-0100-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15552228" target="_blank">15552228</a></div>
|
||
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<div class="nl"><a target="_blank" href="/pubmed/2956416">Role of nutrition in managing the premenstrual tension syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Abraham GE,
|
||
Rumley RE</span><br />
|
||
<span class="medgenPMjournal">J Reprod Med</span>
|
||
1987 Jun;32(6):405-22.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2956416" target="_blank">2956416</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20serum%20estradiol%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (16)</a></div></div>
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