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<meta name="keywords" content="C0686288, female breast carcinoma in situ, neoplastic process, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A proliferation of atypical neoplastic epithelial cells confined to the mammary ducts of the female breast." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Female Breast Carcinoma In Situ (Concept Id: C0686288)
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<!--
UID=673174
ConceptID=C0686288
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Female Breast Carcinoma In Situ</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>673174</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0686288</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A proliferation of atypical neoplastic epithelial cells confined to the mammary ducts of the female breast. [from <a title="NCI Thesaurus" href="http://ncit.nci.nih.gov" class="defSource" target="_blank">NCI</a>]</div>
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<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Female Breast Carcinoma In Situ</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/871338" ref="tree=MeSH" title="MedGen record for Abnormality of the breast">Abnormality of the breast</a></span><ul><li><span class="TLline"><a href="/medgen/1627648" ref="tree=MeSH" title="MedGen record for Abnormal breast morphology">Abnormal breast morphology</a></span><ul><li><span class="TLline"><a href="/medgen/264172" ref="tree=MeSH" title="MedGen record for Breast neoplasm">Breast neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/146260" ref="tree=MeSH" title="MedGen record for Breast carcinoma">Breast carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/40099" ref="tree=MeSH" title="MedGen record for Female breast carcinoma">Female breast carcinoma</a></span><ul><li><span class="matched_ds">Female Breast Carcinoma In Situ</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/35714673">Breast Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gradishar WJ,
Moran MS,
Abraham J,
Aft R,
Agnese D,
Allison KH,
Anderson B,
Burstein HJ,
Chew H,
Dang C,
Elias AD,
Giordano SH,
Goetz MP,
Goldstein LJ,
Hurvitz SA,
Isakoff SJ,
Jankowitz RC,
Javid SH,
Krishnamurthy J,
Leitch M,
Lyons J,
Mortimer J,
Patel SA,
Pierce LJ,
Rosenberger LH,
Rugo HS,
Sitapati A,
Smith KL,
Smith ML,
Soliman H,
Stringer-Reasor EM,
Telli ML,
Ward JH,
Wisinski KB,
Young JS,
Burns J,
Kumar R</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2022 Jun;20(6):691-722.
doi: 10.6004/jnccn.2022.0030.
<span class="bold">PMID: </span><a href="/pubmed/35714673" target="_blank">35714673</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34772587">Advances and controversies in management of breast ductal carcinoma in situ (DCIS).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Farante G,
Toesca A,
Magnoni F,
Lissidini G,
Vila J,
Mastropasqua M,
Viale G,
Penco S,
Cassano E,
Lazzeroni M,
Bonanni B,
Leonardi MC,
Ripoll-Orts F,
Curigliano G,
Orecchia R,
Galimberti V,
Veronesi P</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2022 Apr;48(4):736-741.
Epub 2021 Nov 9
doi: 10.1016/j.ejso.2021.10.030.
<span class="bold">PMID: </span><a href="/pubmed/34772587" target="_blank">34772587</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27732120">Serous tubal intraepithelial carcinoma (STIC) - clinical impact and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Weinberger V,
Bednarikova M,
Cibula D,
Zikan M</span><br />
<span class="medgenPMjournal">Expert Rev Anticancer Ther</span>
2016 Dec;16(12):1311-1321.
Epub 2016 Oct 22
doi: 10.1080/14737140.2016.1247699.
<span class="bold">PMID: </span><a href="/pubmed/27732120" target="_blank">27732120</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(female%20breast%20carcinoma%20in%20situ)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1143)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/38735296">Ductal carcinoma in situ of the breast: finding the balance between overtreatment and undertreatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Delaloge S,
Khan SA,
Wesseling J,
Whelan T</span><br />
<span class="medgenPMjournal">Lancet</span>
2024 Jun 22;403(10445):2734-2746.
Epub 2024 May 9
doi: 10.1016/S0140-6736(24)00425-2.
<span class="bold">PMID: </span><a href="/pubmed/38735296" target="_blank">38735296</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34813345">Overcoming Barriers in Ductal Carcinoma In Situ Management: From Overtreatment to Optimal Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wright JL,
Rahbar H,
Obeng-Gyasi S,
Carlos R,
Tjoe J,
Wolff AC</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2022 Jan 20;40(3):225-230.
Epub 2021 Nov 23
doi: 10.1200/JCO.21.01674.
<span class="bold">PMID: </span><a href="/pubmed/34813345" target="_blank">34813345</a><a href="/pmc/articles/PMC8760161" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31285590">Ductal carcinoma in situ: to treat or not to treat, that is the question.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">van Seijen M,
Lips EH,
Thompson AM,
Nik-Zainal S,
Futreal A,
Hwang ES,
Verschuur E,
Lane J,
Jonkers J,
Rea DW,
Wesseling J;
PRECISION team</span><br />
<span class="medgenPMjournal">Br J Cancer</span>
2019 Aug;121(4):285-292.
Epub 2019 Jul 9
doi: 10.1038/s41416-019-0478-6.
<span class="bold">PMID: </span><a href="/pubmed/31285590" target="_blank">31285590</a><a href="/pmc/articles/PMC6697179" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30244816">Ductal carcinoma in situ current trends, controversies, and review of literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hong YK,
McMasters KM,
Egger ME,
Ajkay N</span><br />
<span class="medgenPMjournal">Am J Surg</span>
2018 Nov;216(5):998-1003.
Epub 2018 Jun 18
doi: 10.1016/j.amjsurg.2018.06.013.
<span class="bold">PMID: </span><a href="/pubmed/30244816" target="_blank">30244816</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29413653">Lobular Carcinoma In Situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wen HY,
Brogi E</span><br />
<span class="medgenPMjournal">Surg Pathol Clin</span>
2018 Mar;11(1):123-145.
Epub 2017 Dec 8
doi: 10.1016/j.path.2017.09.009.
<span class="bold">PMID: </span><a href="/pubmed/29413653" target="_blank">29413653</a><a href="/pmc/articles/PMC5841603" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8213)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34772587">Advances and controversies in management of breast ductal carcinoma in situ (DCIS).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Farante G,
Toesca A,
Magnoni F,
Lissidini G,
Vila J,
Mastropasqua M,
Viale G,
Penco S,
Cassano E,
Lazzeroni M,
Bonanni B,
Leonardi MC,
Ripoll-Orts F,
Curigliano G,
Orecchia R,
Galimberti V,
Veronesi P</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2022 Apr;48(4):736-741.
Epub 2021 Nov 9
doi: 10.1016/j.ejso.2021.10.030.
<span class="bold">PMID: </span><a href="/pubmed/34772587" target="_blank">34772587</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31513033">Overview of breast cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Watkins EJ</span><br />
<span class="medgenPMjournal">JAAPA</span>
2019 Oct;32(10):13-17.
doi: 10.1097/01.JAA.0000580524.95733.3d.
<span class="bold">PMID: </span><a href="/pubmed/31513033" target="_blank">31513033</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31472981">Ductal carcinoma in situ of breast: update 2019.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Badve SS,
Gökmen-Polar Y</span><br />
<span class="medgenPMjournal">Pathology</span>
2019 Oct;51(6):563-569.
Epub 2019 Aug 28
doi: 10.1016/j.pathol.2019.07.005.
<span class="bold">PMID: </span><a href="/pubmed/31472981" target="_blank">31472981</a><a href="/pmc/articles/PMC6788802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30244816">Ductal carcinoma in situ current trends, controversies, and review of literature.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hong YK,
McMasters KM,
Egger ME,
Ajkay N</span><br />
<span class="medgenPMjournal">Am J Surg</span>
2018 Nov;216(5):998-1003.
Epub 2018 Jun 18
doi: 10.1016/j.amjsurg.2018.06.013.
<span class="bold">PMID: </span><a href="/pubmed/30244816" target="_blank">30244816</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29413653">Lobular Carcinoma In Situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wen HY,
Brogi E</span><br />
<span class="medgenPMjournal">Surg Pathol Clin</span>
2018 Mar;11(1):123-145.
Epub 2017 Dec 8
doi: 10.1016/j.path.2017.09.009.
<span class="bold">PMID: </span><a href="/pubmed/29413653" target="_blank">29413653</a><a href="/pmc/articles/PMC5841603" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7901)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37977261">Partial Breast Irradiation for Patients With Early-Stage Invasive Breast Cancer or Ductal Carcinoma In Situ: An ASTRO Clinical Practice Guideline.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shaitelman SF,
Anderson BM,
Arthur DW,
Bazan JG,
Bellon JR,
Bradfield L,
Coles CE,
Gerber NK,
Kathpal M,
Kim L,
Laronga C,
Meattini I,
Nichols EM,
Pierce LJ,
Poppe MM,
Spears PA,
Vinayak S,
Whelan T,
Lyons JA</span><br />
<span class="medgenPMjournal">Pract Radiat Oncol</span>
2024 Mar-Apr;14(2):112-132.
Epub 2023 Nov 15
doi: 10.1016/j.prro.2023.11.001.
<span class="bold">PMID: </span><a href="/pubmed/37977261" target="_blank">37977261</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35934006">Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chua BH,
Link EK,
Kunkler IH,
Whelan TJ,
Westenberg AH,
Gruber G,
Bryant G,
Ahern V,
Purohit K,
Graham PH,
Akra M,
McArdle O,
O'Brien P,
Harvey JA,
Kirkove C,
Maduro JH,
Campbell ID,
Delaney GP,
Martin JD,
Vu TTT,
Muanza TM,
Neal A,
Olivotto IA;
BIG 3–07/TROG 07.01 trial investigators</span><br />
<span class="medgenPMjournal">Lancet</span>
2022 Aug 6;400(10350):431-440.
doi: 10.1016/S0140-6736(22)01246-6.
<span class="bold">PMID: </span><a href="/pubmed/35934006" target="_blank">35934006</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32442066">De-Escalation of Locoregional Therapy in Low-Risk Disease for DCIS and Early-Stage Invasive Cancer.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hwang ES,
Solin L</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2020 Jul 10;38(20):2230-2239.
Epub 2020 May 22
doi: 10.1200/JCO.19.02888.
<span class="bold">PMID: </span><a href="/pubmed/32442066" target="_blank">32442066</a><a href="/pmc/articles/PMC7343434" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11560982">Ductal carcinoma-in-situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wickerham DL</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2001 Sep 15;19(18 Suppl):98S-100S.
<span class="bold">PMID: </span><a href="/pubmed/11560982" target="_blank">11560982</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2567800">In-situ breast cancer: the EORTC consensus meeting.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">van Dongen JA,
Fentiman IS,
Harris JR,
Holland R,
Peterse JL,
Salvadori B,
Stewart HJ</span><br />
<span class="medgenPMjournal">Lancet</span>
1989 Jul 1;2(8653):25-7.
doi: 10.1016/s0140-6736(89)90263-8.
<span class="bold">PMID: </span><a href="/pubmed/2567800" target="_blank">2567800</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2716)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34772587">Advances and controversies in management of breast ductal carcinoma in situ (DCIS).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Farante G,
Toesca A,
Magnoni F,
Lissidini G,
Vila J,
Mastropasqua M,
Viale G,
Penco S,
Cassano E,
Lazzeroni M,
Bonanni B,
Leonardi MC,
Ripoll-Orts F,
Curigliano G,
Orecchia R,
Galimberti V,
Veronesi P</span><br />
<span class="medgenPMjournal">Eur J Surg Oncol</span>
2022 Apr;48(4):736-741.
Epub 2021 Nov 9
doi: 10.1016/j.ejso.2021.10.030.
<span class="bold">PMID: </span><a href="/pubmed/34772587" target="_blank">34772587</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33819852">Axillary staging in ductal carcinoma in situ with microinvasion: A meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Choi B,
Jegatheeswaran L,
Nakhoul M,
Haria P,
Srivastava R,
Karki S,
Lupi M,
Patel V,
Chakravorty A,
Babu E</span><br />
<span class="medgenPMjournal">Surg Oncol</span>
2021 Jun;37:101557.
Epub 2021 Mar 31
doi: 10.1016/j.suronc.2021.101557.
<span class="bold">PMID: </span><a href="/pubmed/33819852" target="_blank">33819852</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31839281">Use of anastrozole for breast cancer prevention (IBIS-II): long-term results of a randomised controlled trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cuzick J,
Sestak I,
Forbes JF,
Dowsett M,
Cawthorn S,
Mansel RE,
Loibl S,
Bonanni B,
Evans DG,
Howell A;
IBIS-II investigators</span><br />
<span class="medgenPMjournal">Lancet</span>
2020 Jan 11;395(10218):117-122.
Epub 2019 Dec 12
doi: 10.1016/S0140-6736(19)32955-1.
<span class="bold">PMID: </span><a href="/pubmed/31839281" target="_blank">31839281</a><a href="/pmc/articles/PMC6961114" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30005770">Ductal Carcinoma In Situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fu F,
Gilmore RC,
Jacobs LK</span><br />
<span class="medgenPMjournal">Surg Clin North Am</span>
2018 Aug;98(4):725-745.
Epub 2018 May 28
doi: 10.1016/j.suc.2018.03.007.
<span class="bold">PMID: </span><a href="/pubmed/30005770" target="_blank">30005770</a></div>
<div class="nl"><a target="_blank" href="/pubmed/6330539">Lobular carcinoma in situ and intraductal carcinoma of the breast.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Rosen PP</span><br />
<span class="medgenPMjournal">Monogr Pathol</span>
1984;(25):59-105.
<span class="bold">PMID: </span><a href="/pubmed/6330539" target="_blank">6330539</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6672)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/35852797">Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tokura M,
Nakayama J,
Prieto-Vila M,
Shiino S,
Yoshida M,
Yamamoto T,
Watanabe N,
Takayama S,
Suzuki Y,
Okamoto K,
Ochiya T,
Kohno T,
Yatabe Y,
Suto A,
Yamamoto Y</span><br />
<span class="medgenPMjournal">Cancer Res</span>
2022 Sep 16;82(18):3236-3248.
doi: 10.1158/0008-5472.CAN-22-0090.
<span class="bold">PMID: </span><a href="/pubmed/35852797" target="_blank">35852797</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34813345">Overcoming Barriers in Ductal Carcinoma In Situ Management: From Overtreatment to Optimal Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wright JL,
Rahbar H,
Obeng-Gyasi S,
Carlos R,
Tjoe J,
Wolff AC</span><br />
<span class="medgenPMjournal">J Clin Oncol</span>
2022 Jan 20;40(3):225-230.
Epub 2021 Nov 23
doi: 10.1200/JCO.21.01674.
<span class="bold">PMID: </span><a href="/pubmed/34813345" target="_blank">34813345</a><a href="/pmc/articles/PMC8760161" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33821346">The Clinical Utility of DCISionRT(®) on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah C,
Bremer T,
Cox C,
Whitworth P,
Patel R,
Patel A,
Brown E,
Gold L,
Rock D,
Riley L,
Kesslering C,
Brown S,
Gabordi R,
Pellicane J,
Rabinovich R,
Khan S,
Templeton S,
Majithia L,
Willey SC,
Wärnberg F,
Gerber NK,
Shivers S,
Vicini FA</span><br />
<span class="medgenPMjournal">Ann Surg Oncol</span>
2021 Oct;28(11):5974-5984.
Epub 2021 Apr 5
doi: 10.1245/s10434-021-09903-1.
<span class="bold">PMID: </span><a href="/pubmed/33821346" target="_blank">33821346</a><a href="/pmc/articles/PMC8526470" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30005770">Ductal Carcinoma In Situ.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Fu F,
Gilmore RC,
Jacobs LK</span><br />
<span class="medgenPMjournal">Surg Clin North Am</span>
2018 Aug;98(4):725-745.
Epub 2018 May 28
doi: 10.1016/j.suc.2018.03.007.
<span class="bold">PMID: </span><a href="/pubmed/30005770" target="_blank">30005770</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29349758">Is DCIS Overrated?</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Feinberg J,
Wetstone R,
Greenstein D,
Borgen P</span><br />
<span class="medgenPMjournal">Cancer Treat Res</span>
2018;173:53-72.
doi: 10.1007/978-3-319-70197-4_5.
<span class="bold">PMID: </span><a href="/pubmed/29349758" target="_blank">29349758</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5470)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36719288">Supplemental Breast Cancer Screening in Women with Dense Breasts and Negative Mammography: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hussein H,
Abbas E,
Keshavarzi S,
Fazelzad R,
Bukhanov K,
Kulkarni S,
Au F,
Ghai S,
Alabousi A,
Freitas V</span><br />
<span class="medgenPMjournal">Radiology</span>
2023 Mar;306(3):e221785.
Epub 2023 Jan 31
doi: 10.1148/radiol.221785.
<span class="bold">PMID: </span><a href="/pubmed/36719288" target="_blank">36719288</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36130770">Margin status and survival outcomes after breast cancer conservation surgery: prospectively registered systematic review and meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bundred JR,
Michael S,
Stuart B,
Cutress RI,
Beckmann K,
Holleczek B,
Dahlstrom JE,
Gath J,
Dodwell D,
Bundred NJ</span><br />
<span class="medgenPMjournal">BMJ</span>
2022 Sep 21;378:e070346.
doi: 10.1136/bmj-2022-070346.
<span class="bold">PMID: </span><a href="/pubmed/36130770" target="_blank">36130770</a><a href="/pmc/articles/PMC9490551" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33819852">Axillary staging in ductal carcinoma in situ with microinvasion: A meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Choi B,
Jegatheeswaran L,
Nakhoul M,
Haria P,
Srivastava R,
Karki S,
Lupi M,
Patel V,
Chakravorty A,
Babu E</span><br />
<span class="medgenPMjournal">Surg Oncol</span>
2021 Jun;37:101557.
Epub 2021 Mar 31
doi: 10.1016/j.suronc.2021.101557.
<span class="bold">PMID: </span><a href="/pubmed/33819852" target="_blank">33819852</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27987454">Patient-reported outcomes in ductal carcinoma in situ: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">King MT,
Winters ZE,
Olivotto IA,
Spillane AJ,
Chua BH,
Saunders C,
Westenberg AH,
Mann GB,
Burnett P,
Butow P,
Rutherford C</span><br />
<span class="medgenPMjournal">Eur J Cancer</span>
2017 Jan;71:95-108.
Epub 2016 Dec 15
doi: 10.1016/j.ejca.2016.09.035.
<span class="bold">PMID: </span><a href="/pubmed/27987454" target="_blank">27987454</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26501537">Benefits and Harms of Breast Cancer Screening: A Systematic Review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Myers ER,
Moorman P,
Gierisch JM,
Havrilesky LJ,
Grimm LJ,
Ghate S,
Davidson B,
Mongtomery RC,
Crowley MJ,
McCrory DC,
Kendrick A,
Sanders GD</span><br />
<span class="medgenPMjournal">JAMA</span>
2015 Oct 20;314(15):1615-34.
doi: 10.1001/jama.2015.13183.
<span class="bold">PMID: </span><a href="/pubmed/26501537" target="_blank">26501537</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%20Breast%20Carcinoma%20In%20Situ%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (108)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
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