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<!--
|
||
UID=66772
|
||
ConceptID=C0238462
|
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-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Medullary thyroid carcinoma<span class="h1sub">(MTC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66772</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0238462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Medullary thyroid gland carcinoma; MTC</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Medullary thyroid carcinoma (255032005); Medullary carcinoma of thyroid (255032005); MTC - Medullary thyroid carcinoma (255032005); Medullary thyroid carcinoma (1332275004); C cell carcinoma (1332275004); Parafollicular cell carcinoma (1332275004); C cell neuroendocrine neoplasm (1332275004)</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN307044</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0002865">HP:0002865</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0015277" target="_blank">MONDO:0015277</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=1332">ORPHA1332</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The presence of a medullary carcinoma of the thyroid gland. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0549473[DISCUI]&test_type=Clinical" ref="ncbi_uid=107811">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=107811" ref="ncbi_uid=107811">V</a></span></span><span class="TLline"><a href="/medgen/107811" ref="tree=GTR&ncbi_uid=107811&link_uid=107811" title="View MedGen record for 'Thyroid gland carcinoma'">Thyroid gland carcinoma</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0238462[DISCUI]&test_type=Clinical" ref="ncbi_uid=66772">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=66772" ref="ncbi_uid=66772">V</a></span></span><span class="TLline">Medullary thyroid carcinoma</span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/277963" ref="tree=MeSH" title="MedGen record for Epithelial neoplasm">Epithelial neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/2867" ref="tree=MeSH" title="MedGen record for Carcinoma">Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/854345" ref="tree=MeSH" title="MedGen record for Head and neck carcinoma">Head and neck carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1704364" ref="tree=MeSH" title="MedGen record for Head and Neck Neuroendocrine Carcinoma">Head and Neck Neuroendocrine Carcinoma</a></span><ul><li><span class="matched_ds">Medullary thyroid carcinoma</span><ul><li><span class="TLline"><a href="/medgen/897883" ref="tree=MeSH" title="MedGen record for Childhood Thyroid Gland Medullary Carcinoma">Childhood Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/322311" ref="tree=MeSH" title="MedGen record for Familial medullary thyroid carcinoma">Familial medullary thyroid carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1756444" ref="tree=MeSH" title="MedGen record for Recurrent Hereditary Thyroid Gland Medullary Carcinoma">Recurrent Hereditary Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1764319" ref="tree=MeSH" title="MedGen record for Unresectable Hereditary Thyroid Gland Medullary Carcinoma">Unresectable Hereditary Thyroid Gland Medullary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1687138" ref="tree=MeSH" title="MedGen record for Metastatic Thyroid Gland Medullary Carcinoma">Metastatic Thyroid Gland Medullary Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1709689" ref="tree=MeSH" title="MedGen record for Advanced Thyroid Gland Medullary Carcinoma">Advanced Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1709986" ref="tree=MeSH" title="MedGen record for Locally Advanced Thyroid Gland Medullary Carcinoma">Locally Advanced Thyroid Gland Medullary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1667235" ref="tree=MeSH" title="MedGen record for Recurrent Thyroid Gland Medullary Carcinoma">Recurrent Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1792783" ref="tree=MeSH" title="MedGen record for Refractory Thyroid Gland Medullary Carcinoma">Refractory Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/318194" ref="tree=MeSH" title="MedGen record for Sporadic Thyroid Gland Medullary Carcinoma">Sporadic Thyroid Gland Medullary Carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/328048" ref="tree=MeSH" title="MedGen record for Sporadic Thyroid Gland Micromedullary Carcinoma">Sporadic Thyroid Gland Micromedullary Carcinoma</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1634716" ref="tree=MeSH" title="MedGen record for Thyroid Gland Medullary Carcinoma by AJCC v7 Stage">Thyroid Gland Medullary Carcinoma by AJCC v7 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/236955" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Medullary Carcinoma AJCC v7">Stage I Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/236912" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Medullary Carcinoma AJCC v7">Stage II Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/233501" ref="tree=MeSH" title="MedGen record for Stage III Thyroid Gland Medullary Carcinoma AJCC v7">Stage III Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/236944" ref="tree=MeSH" title="MedGen record for Stage IV Thyroid Gland Medullary Carcinoma AJCC v7">Stage IV Thyroid Gland Medullary Carcinoma AJCC v7</a></span><ul><li><span class="TLline"><a href="/medgen/453500" ref="tree=MeSH" title="MedGen record for Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7">Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453501" ref="tree=MeSH" title="MedGen record for Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7">Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li><li><span class="TLline"><a href="/medgen/453502" ref="tree=MeSH" title="MedGen record for Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7">Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/1636313" ref="tree=MeSH" title="MedGen record for Thyroid Gland Medullary Carcinoma by AJCC v8 Stage">Thyroid Gland Medullary Carcinoma by AJCC v8 Stage</a></span><ul><li><span class="TLline"><a href="/medgen/1636941" ref="tree=MeSH" title="MedGen record for Stage I Thyroid Gland Medullary Carcinoma AJCC v8">Stage I Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1646125" ref="tree=MeSH" title="MedGen record for Stage II Thyroid Gland Medullary Carcinoma AJCC v8">Stage II Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1632418" ref="tree=MeSH" title="MedGen record for Stage III Thyroid Gland Medullary Carcinoma AJCC v8">Stage III Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1635306" ref="tree=MeSH" title="MedGen record for Stage IV Thyroid Gland Medullary Carcinoma AJCC v8">Stage IV Thyroid Gland Medullary Carcinoma AJCC v8</a></span><ul><li><span class="TLline"><a href="/medgen/1644386" ref="tree=MeSH" title="MedGen record for Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8">Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1635047" ref="tree=MeSH" title="MedGen record for Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8">Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li><li><span class="TLline"><a href="/medgen/1634317" ref="tree=MeSH" title="MedGen record for Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8">Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8</a></span></li></ul></li></ul></li><li><span class="TLline"><a href="/medgen/83136" ref="tree=MeSH" title="MedGen record for Thyroid Gland Medullary Carcinoma with Amyloid Stroma">Thyroid Gland Medullary Carcinoma with Amyloid Stroma</a></span></li><li><span class="TLline"><a href="/medgen/1713329" ref="tree=MeSH" title="MedGen record for Unresectable Thyroid Gland Medullary Carcinoma">Unresectable Thyroid Gland Medullary Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=8686&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Medullary thyroid carcinoma</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_9958"><div><strong>Multiple endocrine neoplasia type 2A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9958</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025268</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, familial medullary thyroid carcinoma (FMTC, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features of MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9958">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_9959"><div><strong>Multiple endocrine neoplasia type 2B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9959</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025269</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, familial medullary thyroid carcinoma (FMTC, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features of MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9959">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_18013"><div><strong>Neurofibromatosis, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18013</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027831</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Neurofibromatosis 1 (NF1) is a multisystem disorder characterized by multiple café au lait macules, intertriginous freckling, multiple cutaneous neurofibromas, and learning disability or behavior problems. About half of people with NF1 have plexiform neurofibromas, but most are internal and not suspected clinically. Plexiform neurofibromas can cause pain, neurologic deficits, and abnormalities of involved or adjacent structures. Less common but potentially more serious manifestations include optic nerve and other central nervous system gliomas, malignant peripheral nerve sheath tumors, scoliosis, tibial dysplasia, vasculopathy, and gastrointestinal, endocrine, or pulmonary disease.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18013">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322311"><div><strong>Familial medullary thyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322311</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833921</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, familial medullary thyroid carcinoma (FMTC, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features of MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322311">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322311" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial medullary thyroid carcinoma</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9958" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple endocrine neoplasia type 2A</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9959" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple endocrine neoplasia type 2B</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18013" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurofibromatosis, type 1</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35948029">Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haddad RI,
|
||
Bischoff L,
|
||
Ball D,
|
||
Bernet V,
|
||
Blomain E,
|
||
Busaidy NL,
|
||
Campbell M,
|
||
Dickson P,
|
||
Duh QY,
|
||
Ehya H,
|
||
Goldner WS,
|
||
Guo T,
|
||
Haymart M,
|
||
Holt S,
|
||
Hunt JP,
|
||
Iagaru A,
|
||
Kandeel F,
|
||
Lamonica DM,
|
||
Mandel S,
|
||
Markovina S,
|
||
McIver B,
|
||
Raeburn CD,
|
||
Rezaee R,
|
||
Ridge JA,
|
||
Roth MY,
|
||
Scheri RP,
|
||
Shah JP,
|
||
Sipos JA,
|
||
Sippel R,
|
||
Sturgeon C,
|
||
Wang TN,
|
||
Wirth LJ,
|
||
Wong RJ,
|
||
Yeh M,
|
||
Cassara CJ,
|
||
Darlow S</span><br />
|
||
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
|
||
2022 Aug;20(8):925-951.
|
||
doi: 10.6004/jnccn.2022.0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35948029" target="_blank">35948029</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34154310">Current Guidelines for Management of Medullary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim M,
|
||
Kim BH</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab (Seoul)</span>
|
||
2021 Jun;36(3):514-524.
|
||
Epub 2021 Jun 22
|
||
doi: 10.3803/EnM.2021.1082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34154310" target="_blank">34154310</a><a href="/pmc/articles/PMC8258323" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25810047">Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wells SA Jr,
|
||
Asa SL,
|
||
Dralle H,
|
||
Elisei R,
|
||
Evans DB,
|
||
Gagel RF,
|
||
Lee N,
|
||
Machens A,
|
||
Moley JF,
|
||
Pacini F,
|
||
Raue F,
|
||
Frank-Raue K,
|
||
Robinson B,
|
||
Rosenthal MS,
|
||
Santoro M,
|
||
Schlumberger M,
|
||
Shah M,
|
||
Waguespack SG;
|
||
American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma</span><br />
|
||
<span class="medgenPMjournal">Thyroid</span>
|
||
2015 Jun;25(6):567-610.
|
||
doi: 10.1089/thy.2014.0335.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25810047" target="_blank">25810047</a><a href="/pmc/articles/PMC4490627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22medullary%20thyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (254)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/thyroid.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Thyroid Carcinoma, 2024</a></h3>
|
||
<h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng230" target="_blank">UK NICE Guideline NG230, Thyroid cancer: assessment and management</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37417280">FAMILIAL NON-MEDULLARY THYROID CARCINOMA.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guda BB,
|
||
Komisarenko II,
|
||
Ostafiichuk MV,
|
||
Tronko MD</span><br />
|
||
<span class="medgenPMjournal">Exp Oncol</span>
|
||
2023 Jun 26;45(1):70-78.
|
||
doi: 10.15407/exp-oncology.2023.01.070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37417280" target="_blank">37417280</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34154310">Current Guidelines for Management of Medullary Thyroid Carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim M,
|
||
Kim BH</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab (Seoul)</span>
|
||
2021 Jun;36(3):514-524.
|
||
Epub 2021 Jun 22
|
||
doi: 10.3803/EnM.2021.1082.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34154310" target="_blank">34154310</a><a href="/pmc/articles/PMC8258323" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26230601">Thyroid Paraganglioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee SM,
|
||
Policarpio-Nicolas ML</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2015 Aug;139(8):1062-7.
|
||
doi: 10.5858/arpa.2013-0703-RS.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26230601" target="_blank">26230601</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24065313">Elastographic presentation of medullary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Andrioli M,
|
||
Trimboli P,
|
||
Amendola S,
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<div class="nl"><a target="_blank" href="/pubmed/7369463">Nonfamilial medullary thyroid carcinoma.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25810047">Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wells SA Jr,
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Asa SL,
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Dralle H,
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Elisei R,
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Evans DB,
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Gagel RF,
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Lee N,
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Machens A,
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Moley JF,
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Pacini F,
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Raue F,
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Frank-Raue K,
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Robinson B,
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Rosenthal MS,
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Santoro M,
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Schlumberger M,
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Shah M,
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Waguespack SG;
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American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma</span><br />
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<span class="medgenPMjournal">Thyroid</span>
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2015 Jun;25(6):567-610.
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<span class="bold">PMID: </span><a href="/pubmed/25810047" target="_blank">25810047</a><a href="/pmc/articles/PMC4490627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Medullary%20thyroid%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (521)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rossi RL,
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Cady B,
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<div class="nl"><a target="_blank" href="/pubmed/37646181">Medullary thyroid carcinoma.</a></div>
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Mian C,
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<span class="bold">PMID: </span><a href="/pubmed/37646181" target="_blank">37646181</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Medullary%20thyroid%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (863)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/36037729">Clinical practice guidelines for management of medullary thyroid carcinoma: An AGREE II appraisal.</a></div>
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|
||
<span class="bold">PMID: </span><a href="/pubmed/35952700" target="_blank">35952700</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35419855">Suboptimal accuracy of ultrasound and ultrasound-based risk stratification systems in detecting medullary thyroid carcinoma should not be overlooked. Findings from a systematic review with meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferrarazzo G,
|
||
Camponovo C,
|
||
Deandrea M,
|
||
Piccardo A,
|
||
Scappaticcio L,
|
||
Trimboli P</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Nov;97(5):532-540.
|
||
Epub 2022 Apr 22
|
||
doi: 10.1111/cen.14739.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35419855" target="_blank">35419855</a><a href="/pmc/articles/PMC9790631" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25934688">Procalcitonin for detecting medullary thyroid carcinoma: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Trimboli P,
|
||
Seregni E,
|
||
Treglia G,
|
||
Alevizaki M,
|
||
Giovanella L</span><br />
|
||
<span class="medgenPMjournal">Endocr Relat Cancer</span>
|
||
2015 Jun;22(3):R157-64.
|
||
Epub 2015 May 1
|
||
doi: 10.1530/ERC-15-0156.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25934688" target="_blank">25934688</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25781697">Serum calcitonin negative medullary thyroid carcinoma: a systematic review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Trimboli P,
|
||
Giovanella L</span><br />
|
||
<span class="medgenPMjournal">Clin Chem Lab Med</span>
|
||
2015 Sep 1;53(10):1507-14.
|
||
doi: 10.1515/cclm-2015-0058.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25781697" target="_blank">25781697</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Medullary%20thyroid%20carcinoma%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0238462%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C0238462%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (2)</a></li>
|
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<li><a href="/gtr/tests?term=C0238462%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (3)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0238462%5bDISCUI%5d" target="_blank">See all (7)</a></total></li>
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