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<!--
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||
UID=65421
|
||
ConceptID=C0231749
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Knee pain</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65421</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0231749</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Arthralgia (knee); Arthralgias (knees); Knee arthralgia; Pain in the knees</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Pain of joint of knee (1003721002); Pain of knee region (1003722009); Knee pain (1003722009)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0030839">HP:0030839</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Knee pain</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/3593" ref="tree=MeSH" title="MedGen record for Constitutional symptom">Constitutional symptom</a></span><ul><li><span class="TLline"><a href="/medgen/45282" ref="tree=MeSH" title="MedGen record for Pain">Pain</a></span><ul><li><span class="TLline"><a href="/medgen/10540" ref="tree=MeSH" title="MedGen record for Limb pain">Limb pain</a></span><ul><li><span class="TLline"><a href="/medgen/6033" ref="tree=MeSH" title="MedGen record for Lower limb pain">Lower limb pain</a></span><ul><li><span class="matched_ds">Knee pain</span><ul><li><span class="TLline"><a href="/medgen/1057379" ref="tree=MeSH" title="MedGen record for Pain at the anterior aspect of the knee">Pain at the anterior aspect of the knee</a></span></li><li><span class="TLline"><a href="/medgen/1055934" ref="tree=MeSH" title="MedGen record for Pain at the lateral aspect of the knee">Pain at the lateral aspect of the knee</a></span></li><li><span class="TLline"><a href="/medgen/1056854" ref="tree=MeSH" title="MedGen record for Pain at the medial aspect of the knee">Pain at the medial aspect of the knee</a></span></li><li><span class="TLline"><a href="/medgen/1057260" ref="tree=MeSH" title="MedGen record for Pain at the posterior aspect of the knee">Pain at the posterior aspect of the knee</a></span></li><li><span class="TLline"><a href="/medgen/534017" ref="tree=MeSH" title="MedGen record for Wilson sign">Wilson sign</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_140928"><div><strong>Metaphyseal chondrodysplasia, Spahr type</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140928</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0432225</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare, genetic, primary bone dysplasia disease characterized by usually moderate, postnatal short stature, progressive genu vara deformity, a waddling gait, and radiological signs of metaphyseal dysplasia (i.e. irregular, sclerotic and widened metaphyses), in the absence of biochemical abnormalities suggestive of rickets disease. Intermittent knee pain, lordosis, and delayed motor development may also occasionally be associated.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140928">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_226942"><div><strong>Deficiency of hyaluronoglucosaminidase</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>226942</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1291490</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Mucopolysaccharidosis type IX (MPS9) is a rare progressive lysosomal storage disorder caused by the deficiency of the enzyme hyaluronoglucosaminidase-1, which degrades hyaluronan (summary by Imundo et al., 2011).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/226942">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322091"><div><strong>Epiphyseal dysplasia, multiple, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322091</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832998</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children report fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322091">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_333092"><div><strong>Epiphyseal dysplasia, multiple, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>333092</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838429</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children report fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/333092">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347615"><div><strong>Stickler syndrome type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347615</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858084</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Stickler syndrome is a connective tissue disorder that can include ocular findings of myopia, cataract, and retinal detachment; hearing loss that is both conductive and sensorineural; midfacial underdevelopment and cleft palate (either alone or as part of the Pierre Robin sequence); and early-onset degenerative joint disease. Variable phenotypic expression of Stickler syndrome occurs both within and among families; interfamilial variability is in part explained by locus and allelic heterogeneity.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347615">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_355785"><div><strong>Spondyloepiphyseal dysplasia tarda, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>355785</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1866717</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal domiant spondyloepiphyseal dysplasia tarda (autosomal dominant SEDT) is an inherited condition that affects bone growth. Signs and symptoms are generally physically apparent by puberty; however, abnormalities may be seen on X-ray at an earlier age. Affected people may have skeletal abnormalities, short stature (with a short neck and trunk, specifically), scoliosis, kyphosis, lumbar hyperlordosis (exaggerated curvature of the lower back), and early-onset progressive osteoarthritis of the hips and knees. Some cases of autosomal dominant SEDT may be caused by changes (mutations) in the COL2A1 gene. As the name suggests, the condition is inherited in an autosomal dominant manner. Treatment is based on the signs and symptoms present in each person and may include surgery and pain management strategies.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/355785">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_382429"><div><strong>Hypertrophic osteoarthropathy, primary, autosomal dominant</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382429</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2674695</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant primary hypertrophic osteoarthropathy (PHOAD) is characterized by 3 major features: digital clubbing, periostosis, and pachydermia. Patients may also experience joint swelling and pain, and some have reported gastrointestinal symptoms, including watery diarrhea. Males are more commonly affected, and more severely affected, than females (Lee et al., 2016; Xu et al., 2021). Touraine et al. (1935) recognized pachydermoperiostosis (PDP) as a familial disorder with 3 presentations or forms: a complete form with periostosis and pachydermia, an incomplete form without pachydermia, and a forme fruste with pachydermia and minimal skeletal changes. Genetic Heterogeneity Autosomal recessive forms of PHO have been reported (see 259100), including PHOAR2E (614441), which is also caused by mutation in the SLCO2A1 gene. Patients with autosomal recessive PHO do not experience gastrointestinal symptoms.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/382429">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_436517"><div><strong>Epiphyseal dysplasia, multiple, 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>436517</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2675767</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal dominant multiple epiphyseal dysplasia (MED) presents in early childhood, usually with pain in the hips and/or knees after exercise. Affected children report fatigue with long-distance walking. Waddling gait may be present. Adult height is either in the lower range of normal or mildly shortened. The limbs are relatively short in comparison to the trunk. Pain and joint deformity progress, resulting in early-onset osteoarthritis, particularly of the large weight-bearing joints.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/436517">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_411667"><div><strong>Vitamin D-dependent rickets, type 2B</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>411667</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2748783</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Vitamin D-dependent rickets type 2B with normal vitamin D receptor (VDDR2B) is an unusual form of rickets due to abnormal expression of a hormone response element-binding protein that interferes with the normal function of the vitamin D receptor. Vitamin D-dependent rickets type 2A (VDDR2A) is caused by mutation in the vitamin D receptor gene (VDR; 601769), and most patients have alopecia in addition to rickets. For a general phenotypic description and a discussion of genetic heterogeneity of rickets due to disorders in vitamin D metabolism or action, see vitamin D-dependent rickets type 1A (VDDR1A; 264700).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/411667">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_482430"><div><strong>Hypertrophic osteoarthropathy, primary, autosomal recessive, 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>482430</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3280800</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PHOAR2-enteropathy syndrome (PHOAR2E) is characterized by primary hypertrophic osteoarthropathy (PHO) and/or chronic nonspecific ulcers (CNSU) of the small intestine. The cardinal features of PHO are digital clubbing, pachydermia, and periostosis; other manifestations include swelling and pain of the large joints, hyperhidrosis, seborrhea, and acne. CNSU often presents with chronic unexplained anemia and abdominal pain, and patients may exhibit edema due to hypoalbuminemia. Radiologic imaging or endoscopy shows multiple small ulcers, predominantly in the ileum, although the stomach, duodenum, and jejunum are often involved. PHO is more frequent and more severe in male patients, who often also report watery diarrhea, whereas CNSU is more often diagnosed in female patients, who may also show features of PHO such as digital clubbing or arthralgias and swelling of the joints. The same mutations in the SLCO2A1 gene have been reported in patients presenting with either diagnosis, and presumed sex-related modifiers of the manifestations of disease or other genotype/phenotype correlates have yet to be elucidated (Li et al., 2017; Umeno et al., 2018; Hong et al., 2022; Kimball et al., 2024). For a discussion of genetic heterogeneity of PHO, see PHOAR1 (259100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/482430">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_226942" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deficiency of hyaluronoglucosaminidase</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_333092" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphyseal dysplasia, multiple, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322091" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphyseal dysplasia, multiple, 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_436517" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Epiphyseal dysplasia, multiple, 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382429" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic osteoarthropathy, primary, autosomal dominant</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (10)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_482430" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypertrophic osteoarthropathy, primary, autosomal recessive, 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_140928" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Metaphyseal chondrodysplasia, Spahr type</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_355785" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spondyloepiphyseal dysplasia tarda, autosomal dominant</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347615" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Stickler syndrome type 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_411667" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Vitamin D-dependent rickets, type 2B</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37874571">Evaluation and Treatment of Knee Pain: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duong V,
|
||
Oo WM,
|
||
Ding C,
|
||
Culvenor AG,
|
||
Hunter DJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Oct 24;330(16):1568-1580.
|
||
doi: 10.1001/jama.2023.19675.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37874571" target="_blank">37874571</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26390269">Patellar Tendinopathy: Clinical Diagnosis, Load Management, and Advice for Challenging Case Presentations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malliaras P,
|
||
Cook J,
|
||
Purdam C,
|
||
Rio E</span><br />
|
||
<span class="medgenPMjournal">J Orthop Sports Phys Ther</span>
|
||
2015 Nov;45(11):887-98.
|
||
Epub 2015 Sep 21
|
||
doi: 10.2519/jospt.2015.5987.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26390269" target="_blank">26390269</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22134205">Iliotibial band syndrome: evaluation and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Strauss EJ,
|
||
Kim S,
|
||
Calcei JG,
|
||
Park D</span><br />
|
||
<span class="medgenPMjournal">J Am Acad Orthop Surg</span>
|
||
2011 Dec;19(12):728-36.
|
||
doi: 10.5435/00124635-201112000-00003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22134205" target="_blank">22134205</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22knee%20pain%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (409)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38776073">Krill Oil for Knee Osteoarthritis: A Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Laslett LL,
|
||
Scheepers LEJM,
|
||
Antony B,
|
||
Wluka AE,
|
||
Cai G,
|
||
Hill CL,
|
||
March L,
|
||
Keen HI,
|
||
Otahal P,
|
||
Cicuttini FM,
|
||
Jones G</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2024 Jun 18;331(23):1997-2006.
|
||
doi: 10.1001/jama.2024.6063.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38776073" target="_blank">38776073</a><a href="/pmc/articles/PMC11112499" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34324435">Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lee E,
|
||
Padgett B</span><br />
|
||
<span class="medgenPMjournal">Altern Ther Health Med</span>
|
||
2021 Jul;27(4):8-13.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34324435" target="_blank">34324435</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25818716">Patellofemoral pain: epidemiology, pathophysiology, and treatment options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rothermich MA,
|
||
Glaviano NR,
|
||
Li J,
|
||
Hart JM</span><br />
|
||
<span class="medgenPMjournal">Clin Sports Med</span>
|
||
2015 Apr;34(2):313-27.
|
||
Epub 2015 Jan 27
|
||
doi: 10.1016/j.csm.2014.12.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25818716" target="_blank">25818716</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25447976">Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Silverwood V,
|
||
Blagojevic-Bucknall M,
|
||
Jinks C,
|
||
Jordan JL,
|
||
Protheroe J,
|
||
Jordan KP</span><br />
|
||
<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
|
||
2015 Apr;23(4):507-15.
|
||
Epub 2014 Nov 29
|
||
doi: 10.1016/j.joca.2014.11.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25447976" target="_blank">25447976</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8461073">Scoring of patellofemoral disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kujala UM,
|
||
Jaakkola LH,
|
||
Koskinen SK,
|
||
Taimela S,
|
||
Hurme M,
|
||
Nelimarkka O</span><br />
|
||
<span class="medgenPMjournal">Arthroscopy</span>
|
||
1993;9(2):159-63.
|
||
doi: 10.1016/s0749-8063(05)80366-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8461073" target="_blank">8461073</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knee%20pain%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4711)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37874571">Evaluation and Treatment of Knee Pain: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duong V,
|
||
Oo WM,
|
||
Ding C,
|
||
Culvenor AG,
|
||
Hunter DJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2023 Oct 24;330(16):1568-1580.
|
||
doi: 10.1001/jama.2023.19675.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37874571" target="_blank">37874571</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36208881">Osteonecrosis of the Knee: Not all Bone Edema is the Same.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pearl MC,
|
||
Mont MA,
|
||
Scuderi GR</span><br />
|
||
<span class="medgenPMjournal">Orthop Clin North Am</span>
|
||
2022 Oct;53(4):377-392.
|
||
Epub 2022 Sep 14
|
||
doi: 10.1016/j.ocl.2022.06.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36208881" target="_blank">36208881</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35730713">Atypical knee pain.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Berger GK,
|
||
Milligan K,
|
||
Holder EK,
|
||
Schwab JM,
|
||
Rubin LE</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
2022 May;71(4):181-184.
|
||
doi: 10.12788/jfp.0404.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35730713" target="_blank">35730713</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30325638">Knee Pain in Adults and Adolescents: The Initial Evaluation.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">van der Heijden RA,
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Lankhorst NE,
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van Linschoten R,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knee%20pain%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2969)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/29324820">Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Smith BE,
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Selfe J,
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Hendrick P,
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Bateman M,
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<div class="nl"><a target="_blank" href="/pubmed/25818716">Patellofemoral pain: epidemiology, pathophysiology, and treatment options.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rothermich MA,
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Glaviano NR,
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Li J,
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Hart JM</span><br />
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2015 Apr;34(2):313-27.
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<span class="bold">PMID: </span><a href="/pubmed/25818716" target="_blank">25818716</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/22812375">The effectiveness of neuromuscular warm-up strategies, that require no additional equipment, for preventing lower limb injuries during sports participation: a systematic review.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/16755241">Bisphosphonate-associated arthritis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Diaz-Borjon A,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knee%20pain%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1830)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/34024814">Short foot exercises have additional effects on knee pain, foot biomechanics, and lower extremity muscle strength in patients with patellofemoral pain.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kısacık P,
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<div class="portlet_content ln"><span class="medgenPMauthor">Kujala UM,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knee%20pain%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3652)</a></div></div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
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||
<div class="nl"><a target="_blank" href="/pubmed/35954598">Patellofemoral Pain Syndrome Risk Associated with Squats: A Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pereira PM,
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Baptista JS,
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Conceição F,
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Duarte J,
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Ferraz J,
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Costa JT</span><br />
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<span class="medgenPMjournal">Int J Environ Res Public Health</span>
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2022 Jul 28;19(15)
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doi: 10.3390/ijerph19159241.
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<span class="bold">PMID: </span><a href="/pubmed/35954598" target="_blank">35954598</a><a href="/pmc/articles/PMC9367913" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34968719">Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dainese P,
|
||
Wyngaert KV,
|
||
De Mits S,
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Wittoek R,
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Van Ginckel A,
|
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Calders P</span><br />
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<span class="medgenPMjournal">Osteoarthritis Cartilage</span>
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2022 Apr;30(4):516-534.
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||
Epub 2021 Dec 27
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||
doi: 10.1016/j.joca.2021.12.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34968719" target="_blank">34968719</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33744766">A systematic review on conservative treatment options for OSGOOD-Schlatter disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neuhaus C,
|
||
Appenzeller-Herzog C,
|
||
Faude O</span><br />
|
||
<span class="medgenPMjournal">Phys Ther Sport</span>
|
||
2021 May;49:178-187.
|
||
Epub 2021 Mar 9
|
||
doi: 10.1016/j.ptsp.2021.03.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33744766" target="_blank">33744766</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29324820">Incidence and prevalence of patellofemoral pain: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smith BE,
|
||
Selfe J,
|
||
Thacker D,
|
||
Hendrick P,
|
||
Bateman M,
|
||
Moffatt F,
|
||
Rathleff MS,
|
||
Smith TO,
|
||
Logan P</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2018;13(1):e0190892.
|
||
Epub 2018 Jan 11
|
||
doi: 10.1371/journal.pone.0190892.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29324820" target="_blank">29324820</a><a href="/pmc/articles/PMC5764329" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25603546">Exercise for treating patellofemoral pain syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">van der Heijden RA,
|
||
Lankhorst NE,
|
||
van Linschoten R,
|
||
Bierma-Zeinstra SM,
|
||
van Middelkoop M</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2015 Jan 20;1(1):CD010387.
|
||
doi: 10.1002/14651858.CD010387.pub2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25603546" target="_blank">25603546</a><a href="/pmc/articles/PMC10898323" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knee%20pain%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (359)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Knee%20pain" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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