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<meta name="keywords" content="C0231218, does not feel right, feels off-color, feels poorly, feels unwell, general feeling of illness, generally unwell, malaise, not feeling great, not feeling well, sign or symptom, vague bodily discomfort, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A feeling of general discomfort, weakness, or lack of health." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
UID=65412
ConceptID=C0231218
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Malaise</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65412</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0231218</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Does not feel right; Feels off-color; Feels poorly; Feels unwell; General feeling of illness; Generally unwell; Not feeling great; Not feeling well; Vague bodily discomfort</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Feels unwell (367391008); Generally unwell (213257006); General feeling of illness (213257006); Feels off-color (367391008); Feels poorly (367391008); Not feeling great (367391008); Vague bodily discomfort (367391008); Not feeling well (367391008); Does not feel right (367391008); Malaise (367391008)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0033834">HP:0033834</a></td></tr>
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">A feeling of general discomfort, weakness, or lack of health. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Malaise</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/3593" ref="tree=MeSH" title="MedGen record for Constitutional symptom">Constitutional symptom</a></span><ul><li><span class="matched_ds">Malaise</span></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat">
<div class="divPopper rprt" id="rdis_42426"><div><strong>Wilson disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>42426</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0019202</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances or a combination of these in individuals ages three years to older than 70 years. Manifestations in untreated individuals vary among and within families. Liver disease can include recurrent jaundice, simple acute self-limited hepatitis-like illness, autoimmune-type hepatitis, fulminant hepatic failure, or chronic liver disease. Neurologic presentations can include dysarthria, movement disorders (tremors, involuntary movements, chorea, choreoathetosis), dystonia (mask-like facies, rigidity, gait disturbance, pseudobulbar involvement), dysautonomia, seizures, sleep disorders, or insomnia. Psychiatric disturbances can include depression, bipolar disorder / bipolar spectrum disorder, neurotic behaviors, personality changes, or psychosis. Other multisystem involvement can include the eye (Kayser-Fleischer rings), hemolytic anemia, the kidneys, the endocrine glands, and the heart.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/42426">Condition Record</a></div></div>
<div class="divPopper rprt" id="rdis_65121"><div><strong>Cyclical neutropenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>65121</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0221023</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">ELANE-related neutropenia includes congenital neutropenia and cyclic neutropenia, both of which are primary hematologic disorders characterized by recurrent fever, skin and oropharyngeal inflammation (i.e., mouth ulcers, gingivitis, sinusitis, and pharyngitis), and cervical adenopathy. Infectious complications are generally more severe in congenital neutropenia than in cyclic neutropenia. In congenital neutropenia, omphalitis immediately after birth may be the first sign; in untreated children diarrhea, pneumonia, and deep abscesses in the liver, lungs, and subcutaneous tissues are common in the first year of life. After 15 years with granulocyte colony-stimulating factor treatment, the risk of developing myelodysplasia (MDS) or acute myelogenous leukemia (AML) is approximately 15%-25%. Cyclic neutropenia is usually diagnosed within the first year of life based on approximately three-week intervals of fever and oral ulcerations and regular oscillations of blood cell counts. Cellulitis, especially perianal cellulitis, is common during neutropenic periods. Between neutropenic periods, affected individuals are generally healthy. Symptoms improve in adulthood. Cyclic neutropenia is not associated with risk of malignancy or conversion to leukemia.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/65121">Condition Record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_65121" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cyclical neutropenia</a></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_42426" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wilson disease</a></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/33626481">Euglycemic diabetic ketoacidosis: Etiologies, evaluation, and management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Long B,
Lentz S,
Koyfman A,
Gottlieb M</span><br />
<span class="medgenPMjournal">Am J Emerg Med</span>
2021 Jun;44:157-160.
Epub 2021 Feb 16
doi: 10.1016/j.ajem.2021.02.015.
<span class="bold">PMID: </span><a href="/pubmed/33626481" target="_blank">33626481</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31845781">Influenza: Diagnosis and Treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gaitonde DY,
Moore FC,
Morgan MK</span><br />
<span class="medgenPMjournal">Am Fam Physician</span>
2019 Dec 15;100(12):751-758.
<span class="bold">PMID: </span><a href="/pubmed/31845781" target="_blank">31845781</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29431387">Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Saguil A,
Kane S,
Mercado M,
Lauters R</span><br />
<span class="medgenPMjournal">Am Fam Physician</span>
2017 Nov 15;96(10):656-663.
<span class="bold">PMID: </span><a href="/pubmed/29431387" target="_blank">29431387</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22malaise%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (262)</a></div></div>
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<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/37419575">Post-COVID Conditions.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mueller MR,
Ganesh R,
Hurt RT,
Beckman TJ</span><br />
<span class="medgenPMjournal">Mayo Clin Proc</span>
2023 Jul;98(7):1071-1078.
doi: 10.1016/j.mayocp.2023.04.007.
<span class="bold">PMID: </span><a href="/pubmed/37419575" target="_blank">37419575</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33218656">Approach to Acute Weakness.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Khamees D,
Meurer W</span><br />
<span class="medgenPMjournal">Emerg Med Clin North Am</span>
2021 Feb;39(1):173-180.
Epub 2020 Nov 5
doi: 10.1016/j.emc.2020.09.010.
<span class="bold">PMID: </span><a href="/pubmed/33218656" target="_blank">33218656</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28749391">Variations in herpes zoster manifestation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wollina U</span><br />
<span class="medgenPMjournal">Indian J Med Res</span>
2017 Mar;145(3):294-298.
doi: 10.4103/ijmr.IJMR_1622_16.
<span class="bold">PMID: </span><a href="/pubmed/28749391" target="_blank">28749391</a><a href="/pmc/articles/PMC5555057" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18819238">Management of mastitis in breastfeeding women.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spencer JP</span><br />
<span class="medgenPMjournal">Am Fam Physician</span>
2008 Sep 15;78(6):727-31.
<span class="bold">PMID: </span><a href="/pubmed/18819238" target="_blank">18819238</a></div>
<div class="nl"><a target="_blank" href="/pubmed/903543">Temporal arteritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Murray TJ</span><br />
<span class="medgenPMjournal">J Am Geriatr Soc</span>
1977 Oct;25(10):450-3.
doi: 10.1111/j.1532-5415.1977.tb00805.x.
<span class="bold">PMID: </span><a href="/pubmed/903543" target="_blank">903543</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2207)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/39160733">Testomalacia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kalra S,
Dhingra A,
Kapoor N</span><br />
<span class="medgenPMjournal">J Pak Med Assoc</span>
2024 Aug;74(8):1545-1546.
doi: 10.47391/JPMA.24-61.
<span class="bold">PMID: </span><a href="/pubmed/39160733" target="_blank">39160733</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35491064">Cirrhosis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wilson R,
Williams DM</span><br />
<span class="medgenPMjournal">Med Clin North Am</span>
2022 May;106(3):437-446.
Epub 2022 Apr 4
doi: 10.1016/j.mcna.2021.12.001.
<span class="bold">PMID: </span><a href="/pubmed/35491064" target="_blank">35491064</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35151618">Strange malaise.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Philouze P,
Montoy M,
Céruse P</span><br />
<span class="medgenPMjournal">Eur Ann Otorhinolaryngol Head Neck Dis</span>
2022 Nov;139(6):367-368.
Epub 2022 Feb 9
doi: 10.1016/j.anorl.2022.01.003.
<span class="bold">PMID: </span><a href="/pubmed/35151618" target="_blank">35151618</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33218656">Approach to Acute Weakness.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Khamees D,
Meurer W</span><br />
<span class="medgenPMjournal">Emerg Med Clin North Am</span>
2021 Feb;39(1):173-180.
Epub 2020 Nov 5
doi: 10.1016/j.emc.2020.09.010.
<span class="bold">PMID: </span><a href="/pubmed/33218656" target="_blank">33218656</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23062157">Chronic fatigue syndrome: diagnosis and treatment.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yancey JR,
Thomas SM</span><br />
<span class="medgenPMjournal">Am Fam Physician</span>
2012 Oct 15;86(8):741-6.
<span class="bold">PMID: </span><a href="/pubmed/23062157" target="_blank">23062157</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2950)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/38592711">Hemophilia B and gene therapy: a new chapter with etranacogene dezaparvovec.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Anguela XM,
High KA</span><br />
<span class="medgenPMjournal">Blood Adv</span>
2024 Apr 9;8(7):1796-1803.
doi: 10.1182/bloodadvances.2023010511.
<span class="bold">PMID: </span><a href="/pubmed/38592711" target="_blank">38592711</a><a href="/pmc/articles/PMC11006816" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/36111386">Rehabilitation for post-COVID-19 condition through a supervised exercise intervention: A randomized controlled trial.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jimeno-Almazán A,
Franco-López F,
Buendía-Romero Á,
Martínez-Cava A,
Sánchez-Agar JA,
Sánchez-Alcaraz Martínez BJ,
Courel-Ibáñez J,
Pallarés JG</span><br />
<span class="medgenPMjournal">Scand J Med Sci Sports</span>
2022 Dec;32(12):1791-1801.
Epub 2022 Sep 23
doi: 10.1111/sms.14240.
<span class="bold">PMID: </span><a href="/pubmed/36111386" target="_blank">36111386</a><a href="/pmc/articles/PMC9538729" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/19369404">Mycophenolate mofetil versus cyclophosphamide for induction treatment of lupus nephritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Appel GB,
Contreras G,
Dooley MA,
Ginzler EM,
Isenberg D,
Jayne D,
Li LS,
Mysler E,
Sánchez-Guerrero J,
Solomons N,
Wofsy D;
Aspreva Lupus Management Study Group</span><br />
<span class="medgenPMjournal">J Am Soc Nephrol</span>
2009 May;20(5):1103-12.
Epub 2009 Apr 15
doi: 10.1681/ASN.2008101028.
<span class="bold">PMID: </span><a href="/pubmed/19369404" target="_blank">19369404</a><a href="/pmc/articles/PMC2678035" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10718102">Ganirelix.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gillies PS,
Faulds D,
Balfour JA,
Perry CM</span><br />
<span class="medgenPMjournal">Drugs</span>
2000 Jan;59(1):107-11; discussion 112-3.
doi: 10.2165/00003495-200059010-00007.
<span class="bold">PMID: </span><a href="/pubmed/10718102" target="_blank">10718102</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10624375">Chronic fatigue syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Kakumanu S,
Yeager M,
Craig TJ</span><br />
<span class="medgenPMjournal">J Am Osteopath Assoc</span>
1999 Oct;99(10 Su Pt 1):S1-5.
<span class="bold">PMID: </span><a href="/pubmed/10624375" target="_blank">10624375</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2871)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/29951056">Adverse Effects of Immunoglobulin Therapy.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Guo Y,
Tian X,
Wang X,
Xiao Z</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2018;9:1299.
Epub 2018 Jun 8
doi: 10.3389/fimmu.2018.01299.
<span class="bold">PMID: </span><a href="/pubmed/29951056" target="_blank">29951056</a><a href="/pmc/articles/PMC6008653" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/16020887">Infective endocarditis developing as uremia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Miyake M,
Hatta K,
Kameyama T,
Himura Y,
Gen H,
Kobashi Y,
Konishi T</span><br />
<span class="medgenPMjournal">Intern Med</span>
2005 Jun;44(6):598-602.
doi: 10.2169/internalmedicine.44.598.
<span class="bold">PMID: </span><a href="/pubmed/16020887" target="_blank">16020887</a></div>
<div class="nl"><a target="_blank" href="/pubmed/11564966">Terbinafine-induced hepatic dysfunction.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chambers WM,
Millar A,
Jain S,
Burroughs AK</span><br />
<span class="medgenPMjournal">Eur J Gastroenterol Hepatol</span>
2001 Sep;13(9):1115-8.
doi: 10.1097/00042737-200109000-00021.
<span class="bold">PMID: </span><a href="/pubmed/11564966" target="_blank">11564966</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10349064">Carvedilol.</a></div>
<div class="portlet_content ln"><span class="medgenPMjournal">Can Fam Physician</span>
1999 May;45:1199-202, 1205-9.
<span class="bold">PMID: </span><a href="/pubmed/10349064" target="_blank">10349064</a><a href="/pmc/articles/PMC2328581" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9652497">The clinical features of rheumatoid arthritis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grassi W,
De Angelis R,
Lamanna G,
Cervini C</span><br />
<span class="medgenPMjournal">Eur J Radiol</span>
1998 May;27 Suppl 1:S18-24.
doi: 10.1016/s0720-048x(98)00038-2.
<span class="bold">PMID: </span><a href="/pubmed/9652497" target="_blank">9652497</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1425)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/36630958">Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Benichou O,
Coskun T,
Gonciarz MD,
Garhyan P,
Adams AC,
Du Y,
Dunbar JD,
Martin JA,
Mather KJ,
Pickard RT,
Reynolds VL,
Robins DA,
Zvada SP,
Emmerson PJ</span><br />
<span class="medgenPMjournal">Cell Metab</span>
2023 Feb 7;35(2):274-286.e10.
Epub 2023 Jan 10
doi: 10.1016/j.cmet.2022.12.011.
<span class="bold">PMID: </span><a href="/pubmed/36630958" target="_blank">36630958</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31911410">Low-dose naltrexone as a treatment for chronic fatigue syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bolton MJ,
Chapman BP,
Van Marwijk H</span><br />
<span class="medgenPMjournal">BMJ Case Rep</span>
2020 Jan 6;13(1)
doi: 10.1136/bcr-2019-232502.
<span class="bold">PMID: </span><a href="/pubmed/31911410" target="_blank">31911410</a><a href="/pmc/articles/PMC6954765" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31320335">Curious CXR.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pluck G,
Friedman M,
McGrath H</span><br />
<span class="medgenPMjournal">Emerg Med J</span>
2019 Jul;36(7):442-450.
doi: 10.1136/emermed-2019-208453.
<span class="bold">PMID: </span><a href="/pubmed/31320335" target="_blank">31320335</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29188475">Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lerch M,
Mainetti C,
Terziroli Beretta-Piccoli B,
Harr T</span><br />
<span class="medgenPMjournal">Clin Rev Allergy Immunol</span>
2018 Feb;54(1):147-176.
doi: 10.1007/s12016-017-8654-z.
<span class="bold">PMID: </span><a href="/pubmed/29188475" target="_blank">29188475</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25229278">Streptococcal acute pharyngitis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Anjos LM,
Marcondes MB,
Lima MF,
Mondelli AL,
Okoshi MP</span><br />
<span class="medgenPMjournal">Rev Soc Bras Med Trop</span>
2014 Jul;47(4):409-13.
doi: 10.1590/0037-8682-0265-2013.
<span class="bold">PMID: </span><a href="/pubmed/25229278" target="_blank">25229278</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1417)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37791590">Immediate versus delayed versus no antibiotics for respiratory infections.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Spurling GK,
Dooley L,
Clark J,
Askew DA</span><br />
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
2023 Oct 4;10(10):CD004417.
doi: 10.1002/14651858.CD004417.pub6.
<span class="bold">PMID: </span><a href="/pubmed/37791590" target="_blank">37791590</a><a href="/pmc/articles/PMC10548498" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34580069">Characterising long COVID: a living systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Michelen M,
Manoharan L,
Elkheir N,
Cheng V,
Dagens A,
Hastie C,
O'Hara M,
Suett J,
Dahmash D,
Bugaeva P,
Rigby I,
Munblit D,
Harriss E,
Burls A,
Foote C,
Scott J,
Carson G,
Olliaro P,
Sigfrid L,
Stavropoulou C</span><br />
<span class="medgenPMjournal">BMJ Glob Health</span>
2021 Sep;6(9)
doi: 10.1136/bmjgh-2021-005427.
<span class="bold">PMID: </span><a href="/pubmed/34580069" target="_blank">34580069</a><a href="/pmc/articles/PMC8478580" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31668170">Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lockhart PB,
Tampi MP,
Abt E,
Aminoshariae A,
Durkin MJ,
Fouad AF,
Gopal P,
Hatten BW,
Kennedy E,
Lang MS,
Patton LL,
Paumier T,
Suda KJ,
Pilcher L,
Urquhart O,
O'Brien KK,
Carrasco-Labra A</span><br />
<span class="medgenPMjournal">J Am Dent Assoc</span>
2019 Nov;150(11):906-921.e12.
doi: 10.1016/j.adaj.2019.08.020.
<span class="bold">PMID: </span><a href="/pubmed/31668170" target="_blank">31668170</a><a href="/pmc/articles/PMC8270006" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/28748176">Global Epidemiology of Dengue Outbreaks in 1990-2015: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Guo C,
Zhou Z,
Wen Z,
Liu Y,
Zeng C,
Xiao D,
Ou M,
Han Y,
Huang S,
Liu D,
Ye X,
Zou X,
Wu J,
Wang H,
Zeng EY,
Jing C,
Yang G</span><br />
<span class="medgenPMjournal">Front Cell Infect Microbiol</span>
2017;7:317.
Epub 2017 Jul 12
doi: 10.3389/fcimb.2017.00317.
<span class="bold">PMID: </span><a href="/pubmed/28748176" target="_blank">28748176</a><a href="/pmc/articles/PMC5506197" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22189346">Sinusitis (acute).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ah-See K</span><br />
<span class="medgenPMjournal">BMJ Clin Evid</span>
2011 Dec 21;2011
<span class="bold">PMID: </span><a href="/pubmed/22189346" target="_blank">22189346</a><a href="/pmc/articles/PMC3275132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Malaise%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (88)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Malaise" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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