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<!--
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||
UID=6524
|
||
ConceptID=C0027430
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Nasal polyposis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6524</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0027430</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Nasal Polyp; Nasal Polyps; Polyp, Nasal; Polyps, Nasal</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Polyp of nasal cavity (736500007)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0100582">HP:0100582</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0006314" target="_blank">MONDO:0006314</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027430[DISCUI]&test_type=Clinical" ref="ncbi_uid=6524">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Nasal polyposis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867442" ref="tree=MeSH" title="MedGen record for Abnormality of head or neck">Abnormality of head or neck</a></span><ul><li><span class="TLline"><a href="/medgen/867438" ref="tree=MeSH" title="MedGen record for Abnormality of the head">Abnormality of the head</a></span><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/539457" ref="tree=MeSH" title="MedGen record for Abnormality of the nose">Abnormality of the nose</a></span><ul><li><span class="TLline"><a href="/medgen/870795" ref="tree=MeSH" title="MedGen record for Abnormal nasal morphology">Abnormal nasal morphology</a></span><ul><li><span class="TLline"><a href="/medgen/871360" ref="tree=MeSH" title="MedGen record for Abnormal nasal mucosa morphology">Abnormal nasal mucosa morphology</a></span><ul><li><span class="matched_ds">Nasal polyposis</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_41393"><div><strong>Cystic fibrosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41393</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0010674</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine pancreas, intestine, hepatobiliary system, and exocrine sweat glands. Morbidities include recurrent sinusitis and bronchitis, progressive obstructive pulmonary disease with bronchiectasis, exocrine pancreatic deficiency and malnutrition, pancreatitis, gastrointestinal manifestations (meconium ileus, rectal prolapse, distal intestinal obstructive syndrome), liver disease, diabetes, male infertility due to hypoplasia or aplasia of the vas deferens, and reduced fertility or infertility in some women. Pulmonary disease is the major cause of morbidity and mortality in CF.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41393">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_18404"><div><strong>Peutz-Jeghers syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18404</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0031269</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Peutz-Jeghers syndrome (PJS) is characterized by the association of gastrointestinal (GI) polyposis, mucocutaneous pigmentation, and cancer predisposition. PJS-type hamartomatous polyps are most common in the small intestine (in order of prevalence: jejunum, ileum, and duodenum) but can also occur in the stomach, large bowel, and extraintestinal sites including the renal pelvis, bronchus, gall bladder, nasal passages, urinary bladder, and ureters. GI polyps can result in chronic bleeding, anemia, and recurrent obstruction and intussusception requiring repeated laparotomy and bowel resection. Mucocutaneous hyperpigmentation presents in childhood as dark blue to dark brown macules around the mouth, eyes, and nostrils, in the perianal area, and on the buccal mucosa. Hyperpigmented macules on the fingers are common. The macules may fade in puberty and adulthood. Recognition of the distinctive skin manifestations is important especially in individuals who have PJS as the result of a de novo pathogenic variant as these skin findings often predate GI signs and symptoms. Individuals with PJS are at increased risk for a wide variety of epithelial malignancies (colorectal, gastric, pancreatic, breast, and ovarian cancers). Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. Males occasionally develop large calcifying Sertoli cell tumors of the testes, which secrete estrogen and can lead to gynecomastia, advanced skeletal age, and ultimately short stature, if untreated.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18404">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_39125"><div><strong>Polyglandular autoimmune syndrome, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39125</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autoimmune polyglandular syndrome type I (APS1) is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis (Neufeld et al., 1981). However, variable APS1 phenotypes have been observed, even among sibs. In addition, some patients may exhibit apparent isolated hypoparathyroidism, an early manifestation of APS1 with peak incidence at around age 5 years; over long-term follow-up, the development of additional features of APS1 may be observed (Cranston et al., 2022).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/39125">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_137933"><div><strong>Immotile cilia syndrome due to defective radial spokes</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>137933</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0340035</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/137933">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_371972"><div><strong>Pai syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>371972</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1835087</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Pai syndrome is characterized by mild hypertelorism, midline cleft lip, nasal and facial polyps, pericallosal lipoma, ocular anomalies, and normal neuropsychologic development (Guion-Almeida et al., 2007).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/371972">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_324840"><div><strong>Primary ciliary dyskinesia 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324840</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837615</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-5 (CILD5) is an autosomal recessive disorder characterized by early onset of a progressive decline in lung function due to an inability to clear mucus and particles from the airways. Affected individuals have recurrent infections of the sinuses, ears, airways, and lungs. Sperm motility is also decreased. Individuals with CILD5 do not have situs inversus (summary by Olbrich et al., 2012). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/324840">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338258"><div><strong>Primary ciliary dyskinesia 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338258</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1847554</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-2 (CILD2) is an autosomal recessive disorder arising from immotile cilia that lack both outer and inner dynein arms. Ineffective airway mucociliary clearance usually manifests within the first year of life with recurrent infections resulting in a chronic respiratory condition and progressing to permanent lung damage. Some patients have nasal polyps, infertility, or hearing loss. About half of patients have situs inversus (Mitchison et al., 2012). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/338258">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_346868"><div><strong>MHC class I deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>346868</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858266</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Bare lymphocyte syndrome type I (BLS I) is an inherited disorder of the immune system (primary immunodeficiency). Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria or viruses. Starting in childhood, most people with BLS I develop recurrent bacterial infections in the lungs and airways (respiratory tract). These recurrent infections can lead to a condition called bronchiectasis, which damages the passages leading from the windpipe to the lungs (bronchi) and can cause breathing problems.\n\nMany people with BLS I also have open sores (ulcers) on their skin, usually on the face, arms, and legs. These ulcers typically develop in adolescence or young adulthood. Some people with BLS I have no symptoms of the condition.\n\nPeople with BLS I have a shortage of specialized immune proteins called major histocompatibility complex (MHC) class I proteins on cells, including infection-fighting white blood cells (lymphocytes), which is where the condition got its name.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/346868">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347198"><div><strong>Asthma, nasal polyps, and aspirin intolerance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347198</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1859648</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Patients with asthma, nasal polyps, and aspirin intolerance may have severe asthma with rhinosinusitis and nasal polyposis, accompanied by hives, flushing, or abdominal pain following the administration of aspirin or nonsteroidal antiinflammatory drugs (NSAIDs). Severe episodes are life-threatening (summary by Arm and Austen, 2002).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347198">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_462487"><div><strong>Primary ciliary dyskinesia 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462487</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3151137</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary ciliary dyskinesia-15 (CILD15) is an autosomal recessive disorder characterized by recurrent respiratory infections associated with defects in ciliary inner dynein arms and axonemal disorganization (summary by Becker-Heck et al., 2011). For a general phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/462487">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_762332"><div><strong>Primary ciliary dyskinesia 19</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>762332</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3543826</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-19 (CILD19) is an autosomal recessive ciliopathy characterized by chronic sinopulmonary infections, asthenospermia, and immotile cilia. Respiratory epithelial cells and sperm flagella of affected individuals lack both the inner and outer dynein arms. About 50% of patients have situs inversus (summary by Kott et al., 2012). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see 244400.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/762332">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_815873"><div><strong>Primary ciliary dyskinesia 22</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815873</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809543</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-22 (CILD22) is an autosomal recessive disorder caused by defective structure and function of cilia or flagella. Ciliary dysfunction causes respiratory distress in term neonates, impaired mucociliary clearance, chronic cough, sinusitis, bronchiectasis, and male infertility. Defective motility of embryonic nodal cilia leads to situs abnormalities in about 50% of patients. CILD22 is characterized by defects of the inner and outer dynein arms (summary by Zariwala et al., 2013). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/815873">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_816098"><div><strong>Idiopathic CD4 lymphocytopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>816098</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3809768</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Idiopathic CD4 lymphopenia (ICL) is a rare and heterogeneous syndrome defined by a reproducible reduction in the CD4 T-lymphocyte count (less than 300 cells per microliter or less than 20% of total T cells) in the absence of HIV infection or other known causes of immunodeficiency. ICL predisposes to infections and malignancy (summary by Gorska and Alam, 2012).</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/816098">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863453"><div><strong>Primary ciliary dyskinesia 30</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863453</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4015016</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Any primary ciliary dyskinesia in which the cause of the disease is a mutation in the CCDC151 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863453">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934688"><div><strong>Primary ciliary dyskinesia 35</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934688</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310721</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-35 (CILD35) is an autosomal recessive disorder characterized by recurrent upper and lower respiratory infections due to defective ciliary function. Examination of respiratory cilia shows lack of outer dynein arms (ODAs) and immotile cilia. Some patients may have laterality defects (summary by Wallmeier et al., 2016). For a phenotypic description and a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934688">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1646059"><div><strong>Kartagener syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1646059</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551906</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Primary ciliary dyskinesia is a genetically heterogeneous autosomal recessive disorder resulting from loss of function of different parts of the primary ciliary apparatus, most often dynein arms. Kartagener (pronounced KART-agayner) syndrome is characterized by the combination of primary ciliary dyskinesia and situs inversus (270100), and occurs in approximately half of patients with ciliary dyskinesia. Since normal nodal ciliary movement in the embryo is required for normal visceral asymmetry, absence of normal ciliary movement results in a lack of definitive patterning; thus, random chance alone appears to determine whether the viscera take up the normal or reversed left-right position during embryogenesis. This explains why approximately 50% of patients, even within the same family, have situs inversus (Afzelius, 1976; El Zein et al., 2003). Genetic Heterogeneity of Primary Ciliary Dyskinesia Other forms of primary ciliary dyskinesia include CILD2 (606763), caused by mutation in the DNAAF3 gene (614566) on 19q13; CILD3 (608644), caused by mutation in the DNAH5 gene (603335) on 5p15; CILD4 (608646), mapped to 15q13; CILD5 (608647), caused by mutation in the HYDIN gene (610812) on 16q22; CILD6 (610852), caused by mutation in the TXNDC3 gene (607421) on 7p14; CILD7 (611884), caused by mutation in the DNAH11 gene (603339) on 7p15; CILD8 (612274), mapped to 15q24-q25; CILD9 (612444), caused by mutation in the DNAI2 gene (605483) on 17q25; CILD10 (612518), caused by mutation in the DNAAF2 gene (612517) on 14q21; CILD11 (612649), caused by mutation in the RSPH4A gene (612647) on 6q22; CILD12 (612650), caused by mutation in the RSPH9 gene (612648) on 6p21; CILD13 (613193), caused by mutation in the DNAAF1 gene (613190) on 16q24; CILD14 (613807), caused by mutation in the CCDC39 gene (613798) gene on 3q26; CILD15 (613808), caused by mutation in the CCDC40 gene (613799) on 17q25; CILD16 (614017), caused by mutation in the DNAL1 gene (610062) on 14q24; CILD17 (614679), caused by mutation in the DNAAF19 gene (614677) on 17q21; CILD18 (614874), caused by mutation in the DNAAF5 gene (614864) on 7p22; CILD19 (614935), caused by mutation in the DNAAF11 gene (614930) on 8q24; CILD20 (615067), caused by mutation in the CCDC114 gene (615038) on 19q13; CILD21 (615294), caused by mutation in the DRC1 gene (615288) on 2p23; CILD22 (615444), caused by mutation in the ZMYND10 gene (607070) on 3p21; CILD23 (615451), caused by mutation in the ARMC4 gene (615408) on 10p; CILD24 (615481), caused by mutation in the RSPH1 gene (609314) on 21q22; CILD25 (615482), caused by mutation in the DYX1C1 gene (608706) on 15q21; CILD26 (615500), caused by mutation in the C21ORF59 gene (615494) on 21q22; CILD27 (615504), caused by mutation in the CCDC65 gene (611088) on 12q13; CILD28 (615505), caused by mutation in the SPAG1 gene (603395) on 8q22; CILD29 (615872), caused by mutation in the CCNO gene (607752) on 5q11; CILD30 (616037), caused by mutation in the CCDC151 gene (615956) on 19p13; CILD32 (616481), caused by mutation in the RSPH3 gene (615876) on 6q25; CILD33 (616726), caused by mutation in the GAS8 gene (605178) on 16q24; CILD34 (617091), caused by mutation in the DNAJB13 gene (610263) on 11q13; CILD35 (617092), caused by mutation in the TTC25 gene (617095) on 17q21; CILD36 (300991), caused by mutation in the DNAAF6 gene (300933) on Xq22; CILD37 (617577), caused by mutation in the DNAH1 gene (603332) on 3p21; CILD38 (618063), caused by mutation in the CFAP300 gene (618058) on 11q22; CILD39 (618254), caused by mutation in the LRRC56 gene (618227) on 11p15; CILD40 (618300), caused by mutation in the DNAH9 gene (603330) on 17p12; CILD41 (618449), caused by mutation in the GAS2L2 gene (611398) on 17q12; CILD42 (618695), caused by mutation in the MCIDAS gene (614086) on 5q11; CILD43 (618699), caused by mutation in the FOXJ1 gene (602291) on 17q25; CILD44 (618781), caused by mutation in the NEK10 gene (618726) on 3p24; CILD45 (618801), caused by mutation in the TTC12 gene (610732) on 11q23; CILD46 (619436), caused by mutation in the STK36 gene (607652) on 2q35; CILD47 (619466), caused by mutation in the TP73 gene (601990) on 1p36; CILD48 (620032), caused by mutation in the NME5 gene (603575) on chromosome 5q31; CILD49 (620197), caused by mutation in the CFAP74 gene (620187) on chromosome 1p36; CILD50 (620356), caused by mutation in the DNAH7 gene (610061) on chromosome 2q32; CILD51 (620438), caused by mutation in the BRWD1 gene (617824) on chromosome 21q22; CILD52 (620570), caused by mutation in the DAW1 gene (620279) on chromosome 2q36; and CILD53 (620642), caused by mutation in the CLXN gene (619564) on chromosome 8q11. Ciliary abnormalities have also been reported in association with both X-linked and autosomal forms of retinitis pigmentosa. Mutations in the RPGR gene (312610), which underlie X-linked retinitis pigmentosa (RP3; 300029), are in some instances (e.g., 312610.0016) associated with recurrent respiratory infections indistinguishable from immotile cilia syndrome; see 300455. Afzelius (1979) gave an extensive review of cilia and their disorders. There are also several possibly distinct CILDs described based on the electron microscopic appearance of abnormal cilia, including CILD with transposition of the microtubules (215520), CILD with excessively long cilia (242680), and CILD with defective radial spokes (242670).</div>
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||
<div class="spaceAbove nowrap">See: <a href="/medgen/1646059">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1684665"><div><strong>Ciliary dyskinesia, primary, 42</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684665</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231464</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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||
<div class="spaceAbove">Primary ciliary dyskinesia-42 (CILD42) is an autosomal recessive disorder characterized by a defect in motile cilia and ciliary clearance resulting in the onset of respiratory insufficiency soon after birth, and associated with recurrent upper and lower respiratory infections with chronic progressive lung disease. Other more variable features may include infertility and mild hydrocephalus. Patients with this form of the disorder do not have situs abnormalities. The disorder is considered to be a type of ciliopathy known as 'reduced generation of multiple motile cilia' (RGMC) (summary by Boon et al., 2014). For a discussion of genetic heterogeneity of primary ciliary dyskinesia, CILD1 (244400).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1684665">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1824064"><div><strong>Ciliary dyskinesia, primary, 49, without situs inversus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1824064</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5774291</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Primary ciliary dyskinesia-49 (CILD49) without situs inversus is an autosomal recessive disorder characterized by the onset of recurrent respiratory infections, chronic cough, and bronchiectasis in early childhood due to defective ciliary clearance. Affected males also show infertility due to defective flagellar morphology and function. Nasal nitric oxide (NO) levels are normal and situs abnormalities are not observed (Sha et al., 2020; Biebach et al., 2022). For a discussion of genetic heterogeneity of primary ciliary dyskinesia, see CILD1 (244400).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1824064">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1862135"><div><strong>MHC class I deficiency 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1862135</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935617</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">MHC class I deficiency-2 (MHC1D2) is an autosomal recessive immunologic disorder characterized by the onset of chronic bacterial sinobronchial infections in the first or second decades of life. Nasal polyps are common, and chronic necrotizing granulomatous lesions affecting the nasal cavity, upper respiratory tract, or skin, which can be severe, may develop later. The disorder is progressive and patients may develop bronchiectasis and respiratory failure. Patient cells have decreased or absent expression of MHC type I (HLA class I) antigens on the cell surface (summary by de La Salle et al., 1994; Moins-Teisserenc et al., 1999). For a discussion of genetic heterogeneity of MHC class I deficiency, see MHC1D1 (604571).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1862135">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347198" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Asthma, nasal polyps, and aspirin intolerance</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684665" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ciliary dyskinesia, primary, 42</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1824064" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ciliary dyskinesia, primary, 49, without situs inversus</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_41393" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cystic fibrosis</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_816098" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Idiopathic CD4 lymphocytopenia</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (19)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_137933" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immotile cilia syndrome due to defective radial spokes</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1646059" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kartagener syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_346868" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MHC class I deficiency</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1862135" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MHC class I deficiency 2</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_371972" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pai syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18404" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peutz-Jeghers syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_39125" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyglandular autoimmune syndrome, type 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_462487" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 15</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_762332" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 19</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338258" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_815873" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 22</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863453" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 30</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934688" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 35</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324840" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary ciliary dyskinesia 5</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34402066">From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pavord ID,
|
||
Bel EH,
|
||
Bourdin A,
|
||
Chan R,
|
||
Han JK,
|
||
Keene ON,
|
||
Liu MC,
|
||
Martin N,
|
||
Papi A,
|
||
Roufosse F,
|
||
Steinfeld J,
|
||
Wechsler ME,
|
||
Yancey SW</span><br />
|
||
<span class="medgenPMjournal">Allergy</span>
|
||
2022 Mar;77(3):778-797.
|
||
Epub 2021 Sep 16
|
||
doi: 10.1111/all.15056.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34402066" target="_blank">34402066</a><a href="/pmc/articles/PMC9293125" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33012318">Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eschenbacher W,
|
||
Straesser M,
|
||
Knoeddler A,
|
||
Li RC,
|
||
Borish L</span><br />
|
||
<span class="medgenPMjournal">Immunol Allergy Clin North Am</span>
|
||
2020 Nov;40(4):539-547.
|
||
Epub 2020 Sep 9
|
||
doi: 10.1016/j.iac.2020.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012318" target="_blank">33012318</a><a href="/pmc/articles/PMC7539135" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27466852">Immunomodulators in the Treatment of Nasal Polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Halderman AA,
|
||
Lane AP</span><br />
|
||
<span class="medgenPMjournal">Adv Otorhinolaryngol</span>
|
||
2016;79:103-13.
|
||
Epub 2016 Jul 28
|
||
doi: 10.1159/000445141.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27466852" target="_blank">27466852</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22nasal%20polyposis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (203)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39007944">Real-Life Response to Biologics in Severe Asthma with Nasal Polyposis: Insights from the Belgian Severe Asthma Registry.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Demolder F,
|
||
Vanderhelst E,
|
||
Verbanck S,
|
||
Schleich F,
|
||
Louis R,
|
||
Brusselle G,
|
||
Sohy C,
|
||
Michils A,
|
||
Peché R,
|
||
Pilette C,
|
||
Hanon S</span><br />
|
||
<span class="medgenPMjournal">Lung</span>
|
||
2024 Aug;202(4):441-448.
|
||
Epub 2024 Jul 15
|
||
doi: 10.1007/s00408-024-00715-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39007944" target="_blank">39007944</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36473259">Correlation between chronic rhinosinusitis with nasal polyposis (CRSwNP) severity and asthma control.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gelardi M,
|
||
Giancaspro R,
|
||
Ronca G,
|
||
Quaranta VN,
|
||
Daloiso A,
|
||
Bocciolini C,
|
||
Notargiacomo M,
|
||
Lingua C,
|
||
Pecoraro P,
|
||
Iannuzzi L,
|
||
Cassano M;
|
||
Italian Study Group on Nasal Polyps</span><br />
|
||
<span class="medgenPMjournal">Am J Otolaryngol</span>
|
||
2023 Mar-Apr;44(2):103701.
|
||
Epub 2022 Nov 28
|
||
doi: 10.1016/j.amjoto.2022.103701.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36473259" target="_blank">36473259</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35980852">A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miglani A,
|
||
Soler ZM,
|
||
Smith TL,
|
||
Mace JC,
|
||
Schlosser RJ</span><br />
|
||
<span class="medgenPMjournal">Int Forum Allergy Rhinol</span>
|
||
2023 Feb;13(2):116-128.
|
||
Epub 2022 Sep 4
|
||
doi: 10.1002/alr.23059.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35980852" target="_blank">35980852</a><a href="/pmc/articles/PMC9877092" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34543652">Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oykhman P,
|
||
Paramo FA,
|
||
Bousquet J,
|
||
Kennedy DW,
|
||
Brignardello-Petersen R,
|
||
Chu DK</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Apr;149(4):1286-1295.
|
||
Epub 2021 Sep 17
|
||
doi: 10.1016/j.jaci.2021.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34543652" target="_blank">34543652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29625668">Is there a link between nasal polyposis and increased risk for sinonasal malignancy?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pourang D,
|
||
Batech M,
|
||
Karimi K,
|
||
Sheikh J,
|
||
Samant S</span><br />
|
||
<span class="medgenPMjournal">Ann Allergy Asthma Immunol</span>
|
||
2018 Apr;120(4):439-440.
|
||
doi: 10.1016/j.anai.2018.01.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29625668" target="_blank">29625668</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1241)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36894196">IgG4-related disease administered dupilumab: case series and review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanda M,
|
||
Kamekura R,
|
||
Sugawara M,
|
||
Nagahata K,
|
||
Suzuki C,
|
||
Takano K,
|
||
Takahashi H</span><br />
|
||
<span class="medgenPMjournal">RMD Open</span>
|
||
2023 Mar;9(1)
|
||
doi: 10.1136/rmdopen-2023-003026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36894196" target="_blank">36894196</a><a href="/pmc/articles/PMC10008221" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33012318">Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eschenbacher W,
|
||
Straesser M,
|
||
Knoeddler A,
|
||
Li RC,
|
||
Borish L</span><br />
|
||
<span class="medgenPMjournal">Immunol Allergy Clin North Am</span>
|
||
2020 Nov;40(4):539-547.
|
||
Epub 2020 Sep 9
|
||
doi: 10.1016/j.iac.2020.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012318" target="_blank">33012318</a><a href="/pmc/articles/PMC7539135" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30449614">Asthma, rhinitis, and nasal polyp multimorbidities.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castillo Vizuete JA,
|
||
Sastre J,
|
||
Del Cuvillo Bernal A,
|
||
Picado C,
|
||
Martínez Moragón E,
|
||
Ignacio García JM,
|
||
Cisneros Serrano C,
|
||
Álvarez Gutiérrez FJ,
|
||
Mullol Miret J</span><br />
|
||
<span class="medgenPMjournal">Arch Bronconeumol (Engl Ed)</span>
|
||
2019 Mar;55(3):146-155.
|
||
Epub 2018 Nov 16
|
||
doi: 10.1016/j.arbres.2018.09.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30449614" target="_blank">30449614</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27888917">Aspirin-Exacerbated Respiratory Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Walgama ES,
|
||
Hwang PH</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2017 Feb;50(1):83-94.
|
||
doi: 10.1016/j.otc.2016.08.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27888917" target="_blank">27888917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21621055">Allergic fungal rhinosinusitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ryan MW</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2011 Jun;44(3):697-710, ix-x.
|
||
Epub 2011 May 2
|
||
doi: 10.1016/j.otc.2011.03.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21621055" target="_blank">21621055</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (890)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35306180">Chronic Rhinosinusitis With Nasal Polyps: Quality of Life in the Biologics Era.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mullol J,
|
||
Azar A,
|
||
Buchheit KM,
|
||
Hopkins C,
|
||
Bernstein JA</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2022 Jun;10(6):1434-1453.e9.
|
||
Epub 2022 Mar 16
|
||
doi: 10.1016/j.jaip.2022.03.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35306180" target="_blank">35306180</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34543652">Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oykhman P,
|
||
Paramo FA,
|
||
Bousquet J,
|
||
Kennedy DW,
|
||
Brignardello-Petersen R,
|
||
Chu DK</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Apr;149(4):1286-1295.
|
||
Epub 2021 Sep 17
|
||
doi: 10.1016/j.jaci.2021.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34543652" target="_blank">34543652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33012318">Biologics for the Treatment of Allergic Rhinitis, Chronic Rhinosinusitis, and Nasal Polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eschenbacher W,
|
||
Straesser M,
|
||
Knoeddler A,
|
||
Li RC,
|
||
Borish L</span><br />
|
||
<span class="medgenPMjournal">Immunol Allergy Clin North Am</span>
|
||
2020 Nov;40(4):539-547.
|
||
Epub 2020 Sep 9
|
||
doi: 10.1016/j.iac.2020.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33012318" target="_blank">33012318</a><a href="/pmc/articles/PMC7539135" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32524991">Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gevaert P,
|
||
Omachi TA,
|
||
Corren J,
|
||
Mullol J,
|
||
Han J,
|
||
Lee SE,
|
||
Kaufman D,
|
||
Ligueros-Saylan M,
|
||
Howard M,
|
||
Zhu R,
|
||
Owen R,
|
||
Wong K,
|
||
Islam L,
|
||
Bachert C</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2020 Sep;146(3):595-605.
|
||
Epub 2020 Jun 7
|
||
doi: 10.1016/j.jaci.2020.05.032.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32524991" target="_blank">32524991</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32004747">Current and Future Treatments of Rhinitis and Sinusitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patel GB,
|
||
Kern RC,
|
||
Bernstein JA,
|
||
Hae-Sim P,
|
||
Peters AT</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2020 May;8(5):1522-1531.
|
||
Epub 2020 Jan 28
|
||
doi: 10.1016/j.jaip.2020.01.031.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32004747" target="_blank">32004747</a><a href="/pmc/articles/PMC7416524" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (961)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38016003">Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wechsler ME,
|
||
Scelo G,
|
||
Larenas-Linnemann DES,
|
||
Torres-Duque CA,
|
||
Maspero J,
|
||
Tran TN,
|
||
Murray RB,
|
||
Martin N,
|
||
Menzies-Gow AN,
|
||
Hew M,
|
||
Peters MJ,
|
||
Gibson PG,
|
||
Christoff GC,
|
||
Popov TA,
|
||
Côté A,
|
||
Bergeron C,
|
||
Dorscheid D,
|
||
FitzGerald JM,
|
||
Chapman KR,
|
||
Boulet LP,
|
||
Bhutani M,
|
||
Sadatsafavi M,
|
||
Jiménez-Maldonado L,
|
||
Duran-Silva M,
|
||
Rodriguez B,
|
||
Celis-Preciado CA,
|
||
Cano-Rosales DJ,
|
||
Solarte I,
|
||
Fernandez-Sanchez MJ,
|
||
Parada-Tovar P,
|
||
von Bülow A,
|
||
Bjerrum AS,
|
||
Ulrik CS,
|
||
Assing KD,
|
||
Rasmussen LM,
|
||
Hansen S,
|
||
Altraja A,
|
||
Bourdin A,
|
||
Taille C,
|
||
Charriot J,
|
||
Roche N,
|
||
Papaioannou AI,
|
||
Kostikas K,
|
||
Papadopoulos NG,
|
||
Salvi S,
|
||
Long D,
|
||
Mitchell PD,
|
||
Costello R,
|
||
Sirena C,
|
||
Cardini C,
|
||
Heffler E,
|
||
Puggioni F,
|
||
Canonica GW,
|
||
Guida G,
|
||
Iwanaga T,
|
||
Al-Ahmad M,
|
||
García U,
|
||
Kuna P,
|
||
Fonseca JA,
|
||
Al-Lehebi R,
|
||
Koh MS,
|
||
Rhee CK,
|
||
Cosio BG,
|
||
Perez de Llano L,
|
||
Perng DS,
|
||
Huang EW,
|
||
Wang HC,
|
||
Tsai MJ,
|
||
Mahboub B,
|
||
Salameh LIJ,
|
||
Jackson DJ,
|
||
Busby J,
|
||
Heaney LG,
|
||
Pfeffer PE,
|
||
Goddard AG,
|
||
Wang E,
|
||
Hoyte FCL,
|
||
Chapman NM,
|
||
Katial R,
|
||
Carter V,
|
||
Bulathsinhala L,
|
||
Eleangovan N,
|
||
Ariti C,
|
||
Lyu J,
|
||
Porsbjerg C,
|
||
Price DB</span><br />
|
||
<span class="medgenPMjournal">Am J Respir Crit Care Med</span>
|
||
2024 Feb 1;209(3):262-272.
|
||
doi: 10.1164/rccm.202305-0808OC.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38016003" target="_blank">38016003</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37298514">Switching Biological Therapies in Severe Asthma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Scioscia G,
|
||
Nolasco S,
|
||
Campisi R,
|
||
Quarato CMI,
|
||
Caruso C,
|
||
Pelaia C,
|
||
Portacci A,
|
||
Crimi C</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2023 May 31;24(11)
|
||
doi: 10.3390/ijms24119563.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37298514" target="_blank">37298514</a><a href="/pmc/articles/PMC10253346" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34116848">Knowledge Gaps and Research Needs for Biologic Therapy in Rhinology Practice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roland LT,
|
||
Levy JM</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
|
||
2021 Aug;54(4):709-716.
|
||
Epub 2021 Jun 9
|
||
doi: 10.1016/j.otc.2021.04.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34116848" target="_blank">34116848</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29095709">The role of frontal sinus drillouts in nasal polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Orgain CA,
|
||
Harvey RJ</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Otolaryngol Head Neck Surg</span>
|
||
2018 Feb;26(1):34-40.
|
||
doi: 10.1097/MOO.0000000000000425.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29095709" target="_blank">29095709</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27466856">Oral Therapeutics for Rhinosinusitis with Nasal Polyposis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomas AJ,
|
||
Alt JA</span><br />
|
||
<span class="medgenPMjournal">Adv Otorhinolaryngol</span>
|
||
2016;79:138-47.
|
||
Epub 2016 Jul 28
|
||
doi: 10.1159/000445151.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27466856" target="_blank">27466856</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (494)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34599979">Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bachert C,
|
||
Han JK,
|
||
Desrosiers MY,
|
||
Gevaert P,
|
||
Heffler E,
|
||
Hopkins C,
|
||
Tversky JR,
|
||
Barker P,
|
||
Cohen D,
|
||
Emson C,
|
||
Martin UJ,
|
||
Shih VH,
|
||
Necander S,
|
||
Kreindler JL,
|
||
Jison M,
|
||
Werkström V</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Apr;149(4):1309-1317.e12.
|
||
Epub 2021 Sep 29
|
||
doi: 10.1016/j.jaci.2021.08.030.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34599979" target="_blank">34599979</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34543652">Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oykhman P,
|
||
Paramo FA,
|
||
Bousquet J,
|
||
Kennedy DW,
|
||
Brignardello-Petersen R,
|
||
Chu DK</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Apr;149(4):1286-1295.
|
||
Epub 2021 Sep 17
|
||
doi: 10.1016/j.jaci.2021.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34543652" target="_blank">34543652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33357499">Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harrison TW,
|
||
Chanez P,
|
||
Menzella F,
|
||
Canonica GW,
|
||
Louis R,
|
||
Cosio BG,
|
||
Lugogo NL,
|
||
Mohan A,
|
||
Burden A,
|
||
McDermott L,
|
||
Garcia Gil E,
|
||
Zangrilli JG;
|
||
ANDHI study investigators</span><br />
|
||
<span class="medgenPMjournal">Lancet Respir Med</span>
|
||
2021 Mar;9(3):260-274.
|
||
Epub 2020 Dec 22
|
||
doi: 10.1016/S2213-2600(20)30414-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33357499" target="_blank">33357499</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26836729">Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis: A Randomized Clinical Trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bachert C,
|
||
Mannent L,
|
||
Naclerio RM,
|
||
Mullol J,
|
||
Ferguson BJ,
|
||
Gevaert P,
|
||
Hellings P,
|
||
Jiao L,
|
||
Wang L,
|
||
Evans RR,
|
||
Pirozzi G,
|
||
Graham NM,
|
||
Swanson B,
|
||
Hamilton JD,
|
||
Radin A,
|
||
Gandhi NA,
|
||
Stahl N,
|
||
Yancopoulos GD,
|
||
Sutherland ER</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2016 Feb 2;315(5):469-79.
|
||
doi: 10.1001/jama.2015.19330.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26836729" target="_blank">26836729</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19793277">Psychometric validity of the 22-item Sinonasal Outcome Test.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins C,
|
||
Gillett S,
|
||
Slack R,
|
||
Lund VJ,
|
||
Browne JP</span><br />
|
||
<span class="medgenPMjournal">Clin Otolaryngol</span>
|
||
2009 Oct;34(5):447-54.
|
||
doi: 10.1111/j.1749-4486.2009.01995.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19793277" target="_blank">19793277</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (903)</a></div></div>
|
||
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/39326524">Dupilumab Versus Mepolizumab for Chronic Rhinosinusitis With Nasal Polyposis: An Indirect Treatment Comparison.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hopkins C,
|
||
Han JK,
|
||
Fokkens W,
|
||
Wagenmann M,
|
||
Guyot P,
|
||
Khan AH,
|
||
Nash S,
|
||
Wang Z,
|
||
Xu Y,
|
||
Msihid J,
|
||
Neupane B,
|
||
Nag A,
|
||
Bachert C</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol Pract</span>
|
||
2024 Dec;12(12):3393-3401.e15.
|
||
Epub 2024 Sep 24
|
||
doi: 10.1016/j.jaip.2024.09.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39326524" target="_blank">39326524</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38488239">Biologic Therapy in Pediatric Chronic Rhinosinusitis: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rahavi-Ezabadi S,
|
||
Zhou S,
|
||
Lee SE,
|
||
Ference E,
|
||
Magit A,
|
||
Leuin S,
|
||
Mohamed K,
|
||
Rezaei N,
|
||
Patel VA</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Head Neck Surg</span>
|
||
2024 Jul;171(1):35-44.
|
||
Epub 2024 Mar 15
|
||
doi: 10.1002/ohn.717.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38488239" target="_blank">38488239</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35122335">Dupilumab ocular side effects in patients with atopic dermatitis: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neagu N,
|
||
Dianzani C,
|
||
Avallone G,
|
||
Dell'Aquila C,
|
||
Morariu SH,
|
||
Zalaudek I,
|
||
Conforti C</span><br />
|
||
<span class="medgenPMjournal">J Eur Acad Dermatol Venereol</span>
|
||
2022 Jun;36(6):820-835.
|
||
Epub 2022 Feb 17
|
||
doi: 10.1111/jdv.17981.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35122335" target="_blank">35122335</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34543652">Comparative efficacy and safety of monoclonal antibodies and aspirin desensitization for chronic rhinosinusitis with nasal polyposis: A systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Oykhman P,
|
||
Paramo FA,
|
||
Bousquet J,
|
||
Kennedy DW,
|
||
Brignardello-Petersen R,
|
||
Chu DK</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2022 Apr;149(4):1286-1295.
|
||
Epub 2021 Sep 17
|
||
doi: 10.1016/j.jaci.2021.09.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34543652" target="_blank">34543652</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29045815">Eosinophils and eosinophil-associated diseases: An update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">O'Sullivan JA,
|
||
Bochner BS</span><br />
|
||
<span class="medgenPMjournal">J Allergy Clin Immunol</span>
|
||
2018 Feb;141(2):505-517.
|
||
Epub 2017 Oct 16
|
||
doi: 10.1016/j.jaci.2017.09.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29045815" target="_blank">29045815</a><a href="/pmc/articles/PMC5803328" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nasal%20polyposis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (55)</a></div></div>
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0027430%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (11)</a></li>
|
||
<li><a href="/gtr/tests?term=C0027430%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (11)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0027430%5bDISCUI%5d" target="_blank">See all (11)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22nasal%20polyposis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Nasal%20polyposis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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