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<meta name="keywords" content="C0151721, decreased function of male gonad, disease or syndrome, eunuchoidism, eunuchoidism hypogonadism, eunuchoidism, hypogonadism, hypogonadism (in males), hypogonadism and testicular atrophy, hypogonadism, male, male hypogonadism, testicular failure, testicular hypogonadism, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Familial male hypogonadism is a highly heterogeneous category from which some disorders such as Reifenstein syndrome (312300), Kallmann syndrome (see 308700), isolated gonadotropin deficiency, and some other entities can be separated. The presence of an autosomal recessive form is suggested by the occurrence of parental consanguinity (Nowakowski and Lenz, 1961)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=57480
|
||
ConceptID=C0151721
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Male hypogonadism</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57480</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151721</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Eunuchoidism; Hypogonadism, Male</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Eunuchoidism, hypogonadism (48723006); Eunuchoidism hypogonadism (48723006); Testicular hypogonadism (48723006); Eunuchoidism (48723006); Testicular failure (48723006); Male hypogonadism (48723006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0000026">HP:0000026</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0009421" target="_blank">MONDO:0009421</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/241100" target="_blank">241100</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Familial male hypogonadism is a highly heterogeneous category from which some disorders such as Reifenstein syndrome (312300), Kallmann syndrome (see 308700), isolated gonadotropin deficiency, and some other entities can be separated. The presence of an autosomal recessive form is suggested by the occurrence of parental consanguinity (Nowakowski and Lenz, 1961). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_57626"><div><strong>Testicular atrophy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57626</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0156312</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57626">Feature record</a> | <a href="/medgen?term=%22Testicular%20atrophy%22%5BClinical%20Features%5D%20OR%2057626%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_163083"><div><strong>Hypospadias</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163083</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0848558</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/163083">Feature record</a> | <a href="/medgen?term=%22Hypospadias%22%5BClinical%20Features%5D%20OR%20163083%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1633603"><div><strong>Micropenis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1633603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551492</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1633603">Feature record</a> | <a href="/medgen?term=%22Micropenis%22%5BClinical%20Features%5D%20OR%201633603%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_57480"><div><strong>Male hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57480</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151721</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial male hypogonadism is a highly heterogeneous category from which some disorders such as Reifenstein syndrome (312300), Kallmann syndrome (see 308700), isolated gonadotropin deficiency, and some other entities can be separated. The presence of an autosomal recessive form is suggested by the occurrence of parental consanguinity (Nowakowski and Lenz, 1961).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/57480">Feature record</a> | <a href="/medgen?term=%22Male%20hypogonadism%22%5BClinical%20Features%5D%20OR%2057480%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_6694"><div><strong>Gynecomastia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6694</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0018418</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal development of large mammary glands in males resulting in breast enlargement.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/6694">Feature record</a> | <a href="/medgen?term=%22Gynecomastia%22%5BClinical%20Features%5D%20OR%206694%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the breast</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_6694" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gynecomastia</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57480" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Male hypogonadism</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_163083" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypospadias</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1633603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Micropenis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_57626" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Testicular atrophy</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0151721[DISCUI]&test_type=Clinical" ref="ncbi_uid=57480">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=57480" target="_blank" href="/omim/241100">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Male hypogonadism</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/4043" ref="tree=MeSH" title="MedGen record for Disorder of endocrine system">Disorder of endocrine system</a></span><ul><li><span class="TLline"><a href="/medgen/9074" ref="tree=MeSH" title="MedGen record for Gonadal disorder">Gonadal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5711" ref="tree=MeSH" title="MedGen record for Hypogonadism">Hypogonadism</a></span><ul><li><span class="matched_ds">Male hypogonadism</span><ul><li><span class="TLline"><a href="/medgen/588672" ref="tree=MeSH" title="MedGen record for Acquired testicular failure">Acquired testicular failure</a></span></li><li><span class="TLline"><a href="/medgen/1378969" ref="tree=MeSH" title="MedGen record for Congenital Testicular Failure">Congenital Testicular Failure</a></span></li><li><span class="TLline"><a href="/medgen/235162" ref="tree=MeSH" title="MedGen record for Primary testicular failure">Primary testicular failure</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_39125"><div><strong>Polyglandular autoimmune syndrome, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>39125</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0085859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Autoimmune polyglandular syndrome type I (APS1) is characterized by the presence of 2 of 3 major clinical symptoms: Addison disease, and/or hypoparathyroidism, and/or chronic mucocutaneous candidiasis (Neufeld et al., 1981). However, variable APS1 phenotypes have been observed, even among sibs. In addition, some patients may exhibit apparent isolated hypoparathyroidism, an early manifestation of APS1 with peak incidence at around age 5 years; over long-term follow-up, the development of additional features of APS1 may be observed (Cranston et al., 2022).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/39125">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_57480"><div><strong>Male hypogonadism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>57480</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151721</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Familial male hypogonadism is a highly heterogeneous category from which some disorders such as Reifenstein syndrome (312300), Kallmann syndrome (see 308700), isolated gonadotropin deficiency, and some other entities can be separated. The presence of an autosomal recessive form is suggested by the occurrence of parental consanguinity (Nowakowski and Lenz, 1961).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/57480">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_82881"><div><strong>Isolated lutropin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82881</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271582</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Male patients with hypogonadotropic hypogonadism due to isolated luteinizing hormone (LH) deficiency have normal sexual differentiation but fail to develop spontaneous puberty. Absence of LH alters Leydig cell proliferation and maturation and impairs the onset of normal spermatogenesis, which requires high levels of intratesticular testosterone. Infertility and very low levels of spermatogenesis generally persist in affected men despite long-term exposure to gonadotropin therapy. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea (summary by Basciani et al., 2012). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a general phenotypic description and discussion of genetic heterogeneity of hypogonadotropic hypogonadism, see 147950. Reviews Arnhold et al. (2009) noted that the clinical manifestations of female patients with hypogonadotropic hypogonadism due to mutations in LHB are very similar to those of women with hypergonadotropic hypogonadism due to inactivating mutations of the LH receptor (see 238320): all have female external genitalia, spontaneous development of normal pubic hair and breasts at puberty, and normal to late menarche followed by oligoamenorrhea and infertility. Pelvic ultrasound shows a small or normal uterus and normal or enlarged ovaries with cysts. However, women with LHB mutations can be treated with luteinizing hormone or chorionic gonadotropin (CG; 118860) replacement therapy; women with LH receptor mutations are resistant to LH, and no treatment is effective in recovering their fertility.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/82881">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_163232"><div><strong>X-linked intellectual disability-psychosis-macroorchidism syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>163232</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0796222</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">The spectrum of MECP2-related phenotypes in females ranges from classic Rett syndrome to variant Rett syndrome with a broader clinical phenotype (either milder or more severe than classic Rett syndrome) to mild learning disabilities; the spectrum in males ranges from severe neonatal encephalopathy to pyramidal signs, parkinsonism, and macroorchidism (PPM-X) syndrome to severe syndromic/nonsyndromic intellectual disability. Females: Classic Rett syndrome, a progressive neurodevelopmental disorder primarily affecting girls, is characterized by apparently normal psychomotor development during the first six to 18 months of life, followed by a short period of developmental stagnation, then rapid regression in language and motor skills, followed by long-term stability. During the phase of rapid regression, repetitive, stereotypic hand movements replace purposeful hand use. Additional findings include fits of screaming and inconsolable crying, autistic features, panic-like attacks, bruxism, episodic apnea and/or hyperpnea, gait ataxia and apraxia, tremors, seizures, and acquired microcephaly. Males: Severe neonatal-onset encephalopathy, the most common phenotype in affected males, is characterized by a relentless clinical course that follows a metabolic-degenerative type of pattern, abnormal tone, involuntary movements, severe seizures, and breathing abnormalities. Death often occurs before age two years.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/163232">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_334557"><div><strong>Male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>334557</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1843994</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">This syndrome is characterized by hypergonadotropic hypogonadism, intellectual deficit, congenital skeletal anomalies involving the cervical spine and superior ribs, and diabetes mellitus.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/334557">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_375855"><div><strong>MEHMO syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>375855</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1846278</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">MEHMO syndrome is a rare intellectual disability disorder that exhibits phenotypic heterogeneity and is variably characterized by impaired intellectual development, epileptic seizures, hypogonadism with hypogenitalism, microcephaly, and obesity. Life expectancy ranges from less than 1 year to adulthood, and the condition is associated with significant morbidity and mortality (summary by Gregory et al., 2019).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/375855">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_383787"><div><strong>Hypogonadism with low-grade mental deficiency and microcephaly</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>383787</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855858</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/383787">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_344596"><div><strong>Hypergonadotropic hypogonadism-cataract syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>344596</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1855859</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Syndrome with the association of hypergonadotropic hypogonadism and cataracts with onset during adolescence. It has been described in three brothers from a consanguineous family. An autosomal recessive mode of transmission appears likely.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/344596">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_419735"><div><strong>Nephropathic cystinosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>419735</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2931187</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Cystinosis comprises three allelic phenotypes: Nephropathic cystinosis in untreated children is characterized by renal Fanconi syndrome, poor growth, hypophosphatemic/calcipenic rickets, impaired glomerular function resulting in complete glomerular failure, and accumulation of cystine in almost all cells, leading to cellular dysfunction with tissue and organ impairment. The typical untreated child has short stature, rickets, and photophobia. Failure to thrive is generally noticed after approximately age six months; signs of renal tubular Fanconi syndrome (polyuria, polydipsia, dehydration, and acidosis) appear as early as age six months; corneal crystals can be present before age one year and are always present after age 16 months. Prior to the use of renal transplantation and cystine-depleting therapy, the life span in nephropathic cystinosis was no longer than ten years. With these interventions, affected individuals can survive at least into the mid-forties or fifties with satisfactory quality of life. Intermediate cystinosis is characterized by all the typical manifestations of nephropathic cystinosis, but onset is at a later age. Renal glomerular failure occurs in all untreated affected individuals, usually between ages 15 and 25 years. The non-nephropathic (ocular) form of cystinosis is characterized clinically only by photophobia resulting from corneal cystine crystal accumulation.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/419735">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_811623"><div><strong>Mandibular hypoplasia-deafness-progeroid syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>811623</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3715192</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome (MDPL) is an autosomal dominant systemic disorder characterized by prominent loss of subcutaneous fat, a characteristic facial appearance, and metabolic abnormalities including insulin resistance and diabetes mellitus. Sensorineural deafness occurs late in the first or second decades of life (summary by Weedon et al., 2013).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/811623">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_934674"><div><strong>Bardet-Biedl syndrome 20</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934674</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310707</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Bardet-Biedl syndrome-20 (BBS20), a rare autosomal recessive disorder associated with ciliary dysfunction, is characterized by rod-cone dystrophy, postaxial polydactyly, truncal obesity, renal anomalies, and learning disability, as well as hypogonadism in males and genital abnormalities in females (Saida et al., 2014). For a general phenotypic description and discussion of genetic heterogeneity of Bardet-Biedl syndrome, see BBS1 (209900).</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/934674">Condition Record</a></div></div>
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<div class="divPopper rprt" id="rdis_1684764"><div><strong>Rothmund-Thomson syndrome type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1684764</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5231433</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
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<div class="spaceAbove">Rothmund-Thomson syndrome (RTS) is characterized by a rash that progresses to poikiloderma; sparse hair, eyelashes, and/or eyebrows; small size; skeletal and dental abnormalities; juvenile cataracts; and an increased risk for cancer, especially osteosarcoma. A variety of benign and malignant hematologic abnormalities have been reported in affected individuals. The rash of RTS typically develops between ages three and six months (occasionally as late as age two years) as erythema, swelling, and blistering on the face, subsequently spreading to the buttocks and extremities. The rash evolves over months to years into the chronic pattern of reticulated hypo- and hyperpigmentation, telangiectasias, and punctate atrophy (collectively known as poikiloderma) that persist throughout life. Hyperkeratotic lesions occur in approximately one third of individuals. Skeletal abnormalities can include radial ray defects, ulnar defects, absent or hypoplastic patella, and osteopenia.</div>
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<div class="spaceAbove nowrap">See: <a href="/medgen/1684764">Condition Record</a></div></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934674" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bardet-Biedl syndrome 20</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_344596" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypergonadotropic hypogonadism-cataract syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_383787" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hypogonadism with low-grade mental deficiency and microcephaly</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82881" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Isolated lutropin deficiency</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_334557" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Male hypergonadotropic hypogonadism-intellectual disability-skeletal anomalies syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (12)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_57480" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Male hypogonadism</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_811623" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mandibular hypoplasia-deafness-progeroid syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_375855" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MEHMO syndrome</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_419735" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Nephropathic cystinosis</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_39125" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polyglandular autoimmune syndrome, type 1</a></div>
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<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1684764" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Rothmund-Thomson syndrome type 1</a></div>
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||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_163232" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">X-linked intellectual disability-psychosis-macroorchidism syndrome</a></div></span></div></div>
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</div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/39159641">Male hypogonadism: pathogenesis, diagnosis, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Silva NL,
|
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Papanikolaou N,
|
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Grossmann M,
|
||
Antonio L,
|
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Quinton R,
|
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Anawalt BD,
|
||
Jayasena CN</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 Oct;12(10):761-774.
|
||
Epub 2024 Aug 16
|
||
doi: 10.1016/S2213-8587(24)00199-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39159641" target="_blank">39159641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34811785">Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jayasena CN,
|
||
Anderson RA,
|
||
Llahana S,
|
||
Barth JH,
|
||
MacKenzie F,
|
||
Wilkes S,
|
||
Smith N,
|
||
Sooriakumaran P,
|
||
Minhas S,
|
||
Wu FCW,
|
||
Tomlinson J,
|
||
Quinton R</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Feb;96(2):200-219.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1111/cen.14633.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34811785" target="_blank">34811785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29550857">Evaluation and Treatment of Male Hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sargis RM,
|
||
Davis AM</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2018 Apr 3;319(13):1375-1376.
|
||
doi: 10.1001/jama.2018.3182.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29550857" target="_blank">29550857</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22male%20hypogonadism%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (92)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39159641">Male hypogonadism: pathogenesis, diagnosis, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Silva NL,
|
||
Papanikolaou N,
|
||
Grossmann M,
|
||
Antonio L,
|
||
Quinton R,
|
||
Anawalt BD,
|
||
Jayasena CN</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 Oct;12(10):761-774.
|
||
Epub 2024 Aug 16
|
||
doi: 10.1016/S2213-8587(24)00199-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39159641" target="_blank">39159641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34183196">European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Bettocchi C,
|
||
Boeri L,
|
||
Capogrosso P,
|
||
Carvalho J,
|
||
Cilesiz NC,
|
||
Cocci A,
|
||
Corona G,
|
||
Dimitropoulos K,
|
||
Gül M,
|
||
Hatzichristodoulou G,
|
||
Jones TH,
|
||
Kadioglu A,
|
||
Martínez Salamanca JI,
|
||
Milenkovic U,
|
||
Modgil V,
|
||
Russo GI,
|
||
Serefoglu EC,
|
||
Tharakan T,
|
||
Verze P,
|
||
Minhas S;
|
||
EAU Working Group on Male Sexual and Reproductive Health</span><br />
|
||
<span class="medgenPMjournal">Eur Urol</span>
|
||
2021 Sep;80(3):333-357.
|
||
Epub 2021 Jun 26
|
||
doi: 10.1016/j.eururo.2021.06.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34183196" target="_blank">34183196</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31147553">Paediatric and adult-onset male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Rastrelli G,
|
||
Hackett G,
|
||
Seminara SB,
|
||
Huhtaniemi IT,
|
||
Rey RA,
|
||
Hellstrom WJG,
|
||
Palmert MR,
|
||
Corona G,
|
||
Dohle GR,
|
||
Khera M,
|
||
Chan YM,
|
||
Maggi M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2019 May 30;5(1):38.
|
||
doi: 10.1038/s41572-019-0087-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31147553" target="_blank">31147553</a><a href="/pmc/articles/PMC6944317" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29530796">Testosterone replacement therapy: For whom, when and how?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsametis CP,
|
||
Isidori AM</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:69-78.
|
||
Epub 2018 Mar 9
|
||
doi: 10.1016/j.metabol.2018.03.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29530796" target="_blank">29530796</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22173246">Metabolic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cho LW</span><br />
|
||
<span class="medgenPMjournal">Singapore Med J</span>
|
||
2011 Nov;52(11):779-85.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22173246" target="_blank">22173246</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (300)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39159641">Male hypogonadism: pathogenesis, diagnosis, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Silva NL,
|
||
Papanikolaou N,
|
||
Grossmann M,
|
||
Antonio L,
|
||
Quinton R,
|
||
Anawalt BD,
|
||
Jayasena CN</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 Oct;12(10):761-774.
|
||
Epub 2024 Aug 16
|
||
doi: 10.1016/S2213-8587(24)00199-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39159641" target="_blank">39159641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34811785">Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jayasena CN,
|
||
Anderson RA,
|
||
Llahana S,
|
||
Barth JH,
|
||
MacKenzie F,
|
||
Wilkes S,
|
||
Smith N,
|
||
Sooriakumaran P,
|
||
Minhas S,
|
||
Wu FCW,
|
||
Tomlinson J,
|
||
Quinton R</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Feb;96(2):200-219.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1111/cen.14633.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34811785" target="_blank">34811785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31147553">Paediatric and adult-onset male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Rastrelli G,
|
||
Hackett G,
|
||
Seminara SB,
|
||
Huhtaniemi IT,
|
||
Rey RA,
|
||
Hellstrom WJG,
|
||
Palmert MR,
|
||
Corona G,
|
||
Dohle GR,
|
||
Khera M,
|
||
Chan YM,
|
||
Maggi M</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2019 May 30;5(1):38.
|
||
doi: 10.1038/s41572-019-0087-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31147553" target="_blank">31147553</a><a href="/pmc/articles/PMC6944317" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29530796">Testosterone replacement therapy: For whom, when and how?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tsametis CP,
|
||
Isidori AM</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:69-78.
|
||
Epub 2018 Mar 9
|
||
doi: 10.1016/j.metabol.2018.03.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29530796" target="_blank">29530796</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24119423">Male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Basaria S</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2014 Apr 5;383(9924):1250-63.
|
||
Epub 2013 Oct 10
|
||
doi: 10.1016/S0140-6736(13)61126-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24119423" target="_blank">24119423</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (253)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39159641">Male hypogonadism: pathogenesis, diagnosis, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">De Silva NL,
|
||
Papanikolaou N,
|
||
Grossmann M,
|
||
Antonio L,
|
||
Quinton R,
|
||
Anawalt BD,
|
||
Jayasena CN</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 Oct;12(10):761-774.
|
||
Epub 2024 Aug 16
|
||
doi: 10.1016/S2213-8587(24)00199-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39159641" target="_blank">39159641</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36309423">Testosterone Replacement Options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McCullough AR,
|
||
Khan M</span><br />
|
||
<span class="medgenPMjournal">Urol Clin North Am</span>
|
||
2022 Nov;49(4):679-693.
|
||
doi: 10.1016/j.ucl.2022.07.010.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36309423" target="_blank">36309423</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34933414">Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
de Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2022 Mar;10(3):451-469.
|
||
Epub 2022 Jan 8
|
||
doi: 10.1111/andr.13146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34933414" target="_blank">34933414</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34811785">Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jayasena CN,
|
||
Anderson RA,
|
||
Llahana S,
|
||
Barth JH,
|
||
MacKenzie F,
|
||
Wilkes S,
|
||
Smith N,
|
||
Sooriakumaran P,
|
||
Minhas S,
|
||
Wu FCW,
|
||
Tomlinson J,
|
||
Quinton R</span><br />
|
||
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
|
||
2022 Feb;96(2):200-219.
|
||
Epub 2021 Nov 22
|
||
doi: 10.1111/cen.14633.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34811785" target="_blank">34811785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24119423">Male hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Basaria S</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2014 Apr 5;383(9924):1250-63.
|
||
Epub 2013 Oct 10
|
||
doi: 10.1016/S0140-6736(13)61126-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24119423" target="_blank">24119423</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (323)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36998229">Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
Beck JJH,
|
||
De Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Diabetes Metab</span>
|
||
2023 May;6(3):e416.
|
||
Epub 2023 Mar 30
|
||
doi: 10.1002/edm2.416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36998229" target="_blank">36998229</a><a href="/pmc/articles/PMC10164424" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36918505">Bone quality in endocrine diseases: determinants and clinical relevance.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cianferotti L,
|
||
Cipriani C,
|
||
Corbetta S,
|
||
Corona G,
|
||
Defeudis G,
|
||
Lania AG,
|
||
Messina C,
|
||
Napoli N,
|
||
Mazziotti G</span><br />
|
||
<span class="medgenPMjournal">J Endocrinol Invest</span>
|
||
2023 Jul;46(7):1283-1304.
|
||
Epub 2023 Mar 14
|
||
doi: 10.1007/s40618-023-02056-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36918505" target="_blank">36918505</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32170412">Hypertension and Reproduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nilsson PM,
|
||
Viigimaa M,
|
||
Giwercman A,
|
||
Cifkova R</span><br />
|
||
<span class="medgenPMjournal">Curr Hypertens Rep</span>
|
||
2020 Mar 13;22(4):29.
|
||
doi: 10.1007/s11906-020-01036-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32170412" target="_blank">32170412</a><a href="/pmc/articles/PMC7069900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18594278">Testosterone replacement in men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beg S,
|
||
Al-Khoury L,
|
||
Cunningham GR</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Endocrinol Diabetes Obes</span>
|
||
2008 Aug;15(4):364-70.
|
||
doi: 10.1097/MED.0b013e328305081a.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18594278" target="_blank">18594278</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9645824">Klinefelter syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Smyth CM,
|
||
Bremner WJ</span><br />
|
||
<span class="medgenPMjournal">Arch Intern Med</span>
|
||
1998 Jun 22;158(12):1309-14.
|
||
doi: 10.1001/archinte.158.12.1309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9645824" target="_blank">9645824</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (74)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38459012">Stem Leydig cells support macrophage immunological homeostasis through mitochondrial transfer in mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chi A,
|
||
Yang B,
|
||
Dai H,
|
||
Li X,
|
||
Mo J,
|
||
Gao Y,
|
||
Chen Z,
|
||
Feng X,
|
||
Ma M,
|
||
Li Y,
|
||
Yang C,
|
||
Liu J,
|
||
Liu H,
|
||
Wang Z,
|
||
Gao F,
|
||
Liao Y,
|
||
Shi X,
|
||
Deng C,
|
||
Zhang M</span><br />
|
||
<span class="medgenPMjournal">Nat Commun</span>
|
||
2024 Mar 8;15(1):2120.
|
||
doi: 10.1038/s41467-024-46190-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38459012" target="_blank">38459012</a><a href="/pmc/articles/PMC10924100" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36998229">Clomiphene citrate: A potential alternative for testosterone therapy in hypogonadal males.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
Beck JJH,
|
||
De Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Diabetes Metab</span>
|
||
2023 May;6(3):e416.
|
||
Epub 2023 Mar 30
|
||
doi: 10.1002/edm2.416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36998229" target="_blank">36998229</a><a href="/pmc/articles/PMC10164424" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34933414">Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
de Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2022 Mar;10(3):451-469.
|
||
Epub 2022 Jan 8
|
||
doi: 10.1111/andr.13146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34933414" target="_blank">34933414</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32170412">Hypertension and Reproduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nilsson PM,
|
||
Viigimaa M,
|
||
Giwercman A,
|
||
Cifkova R</span><br />
|
||
<span class="medgenPMjournal">Curr Hypertens Rep</span>
|
||
2020 Mar 13;22(4):29.
|
||
doi: 10.1007/s11906-020-01036-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32170412" target="_blank">32170412</a><a href="/pmc/articles/PMC7069900" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20625573">Late-onset male hypogonadism and testosterone replacement therapy in primary care.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brunton SA,
|
||
Sadovsky R</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
2010 Jul;59(7 Suppl):S1-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20625573" target="_blank">20625573</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (160)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36013514">Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Leisegang K,
|
||
Finelli R,
|
||
Sikka SC,
|
||
Panner Selvam MK</span><br />
|
||
<span class="medgenPMjournal">Medicina (Kaunas)</span>
|
||
2022 Aug 4;58(8)
|
||
doi: 10.3390/medicina58081047.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36013514" target="_blank">36013514</a><a href="/pmc/articles/PMC9415500" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34933414">Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huijben M,
|
||
Lock MTWT,
|
||
de Kemp VF,
|
||
de Kort LMO,
|
||
van Breda HMK</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2022 Mar;10(3):451-469.
|
||
Epub 2022 Jan 8
|
||
doi: 10.1111/andr.13146.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34933414" target="_blank">34933414</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34183196">European Association of Urology Guidelines on Sexual and Reproductive Health-2021 Update: Male Sexual Dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salonia A,
|
||
Bettocchi C,
|
||
Boeri L,
|
||
Capogrosso P,
|
||
Carvalho J,
|
||
Cilesiz NC,
|
||
Cocci A,
|
||
Corona G,
|
||
Dimitropoulos K,
|
||
Gül M,
|
||
Hatzichristodoulou G,
|
||
Jones TH,
|
||
Kadioglu A,
|
||
Martínez Salamanca JI,
|
||
Milenkovic U,
|
||
Modgil V,
|
||
Russo GI,
|
||
Serefoglu EC,
|
||
Tharakan T,
|
||
Verze P,
|
||
Minhas S;
|
||
EAU Working Group on Male Sexual and Reproductive Health</span><br />
|
||
<span class="medgenPMjournal">Eur Urol</span>
|
||
2021 Sep;80(3):333-357.
|
||
Epub 2021 Jun 26
|
||
doi: 10.1016/j.eururo.2021.06.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34183196" target="_blank">34183196</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25269643">Systematic literature review of the risk factors, comorbidities, and consequences of hypogonadism in men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zarotsky V,
|
||
Huang MY,
|
||
Carman W,
|
||
Morgentaler A,
|
||
Singhal PK,
|
||
Coffin D,
|
||
Jones TH</span><br />
|
||
<span class="medgenPMjournal">Andrology</span>
|
||
2014 Nov;2(6):819-34.
|
||
Epub 2014 Oct 1
|
||
doi: 10.1111/andr.274.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25269643" target="_blank">25269643</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20541464">Male hypogonadism associated with advanced cancer: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vigano A,
|
||
Piccioni M,
|
||
Trutschnigg B,
|
||
Hornby L,
|
||
Chaudhury P,
|
||
Kilgour R</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2010 Jul;11(7):679-84.
|
||
Epub 2010 Jun 10
|
||
doi: 10.1016/S1470-2045(10)70021-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20541464" target="_blank">20541464</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Male%20hypogonadism%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
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||
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0151721%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C0151721%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (5)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0151721%5bDISCUI%5d" target="_blank">See all (5)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=241100" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Male%20hypogonadism" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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</div>
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22male%20hypogonadism%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Male%20hypogonadism%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://catalog.coriell.org/Search?q=241100" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/hypogonadism_male_2" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Male%20hypogonadism" target="_blank">MedlinePlus</a></li></ul></div>
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<a href="/pubmed/clinical?term=Male%20hypogonadism" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
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<li>
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<a href="/pubmed?term=Male%20hypogonadism%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
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<h3>Related information</h3>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0151721[DISCUI]" ref="log$=recordlinks">GTR</a>
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<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C0151721[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
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<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
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||
</li>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/mesh?LinkName=medgen_mesh&from_uid=57480" ref="log$=recordlinks">MeSH</a>
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<div class="brieflinkpop offscreen_noflow">Related Medical Subject Headings</div>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=57480" ref="log$=recordlinks">OMIM</a>
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<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
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||
</li>
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<li class="brieflinkpopper">
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<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=57480" ref="log$=recordlinks">PMC Articles</a>
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<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
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<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=57480" ref="log$=recordlinks">PubMed</a>
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<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
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