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<!--
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UID=572577
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ConceptID=C0338455
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Frontal lobe dementia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>572577</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0338455</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Dementia, frontal lobe</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>DFT - Dementia frontal lobe type (278857002); Dementia of frontal lobe type (278857002)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0000727">HP:0000727</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Frontal lobe dementia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/14336" ref="tree=MeSH" title="MedGen record for Disorder of nervous system">Disorder of nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/3306" ref="tree=MeSH" title="MedGen record for Disorder of the central nervous system">Disorder of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/14214" ref="tree=MeSH" title="MedGen record for Brain disorder">Brain disorder</a></span><ul><li><span class="TLline"><a href="/medgen/99229" ref="tree=MeSH" title="MedGen record for Dementia">Dementia</a></span><ul><li><span class="matched_ds">Frontal lobe dementia</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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<div class="divPopper rprt" id="rdis_83266"><div><strong>Frontotemporal dementia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>83266</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0338451</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">In general, frontotemporal dementia (FTD) refers to a clinical manifestation of the pathologic finding of frontotemporal lobar degeneration (FTLD). FTD, the most common subtype of FTLD, is a behavioral variant characterized by changes in social and personal conduct with loss of volition, executive dysfunction, loss of abstract thought, and decreased speech output. A second clinical subtype of FTLD is 'semantic dementia,' characterized by specific loss of comprehension of language and impaired facial and object recognition. A third clinical subtype of FTLD is 'primary progressive aphasia' (PPA), characterized by a reduction in speech production, speech errors, and word retrieval difficulties resulting in mutism and an inability to communicate. All subtypes have relative preservation of memory, at least in the early stages. FTLD is often associated with parkinsonism or motor neuron disease (MND) resembling amyotrophic lateral sclerosis (ALS; 105400) (reviews by Tolnay and Probst, 2002 and Mackenzie and Rademakers, 2007). Mackenzie et al. (2009, 2010) provided a classification of FTLD subtypes according to the neuropathologic findings (see PATHOGENESIS below). Clinical Variability of Tauopathies Tauopathies comprise a clinically variable group of neurodegenerative diseases characterized neuropathologically by accumulation of abnormal MAPT-positive inclusions in nerve and/or glial cells. In addition to frontotemporal dementia, semantic dementia, and PPA, different clinical syndromes with overlapping features have been described, leading to confusion in the terminology (Tolnay and Probst, 2002). Other terms used historically include parkinsonism and dementia with pallidopontonigral degeneration (PPND) (Wszolek et al., 1992); disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) (Lynch et al., 1994); frontotemporal dementia with parkinsonism (FLDEM) (Yamaoka et al., 1996); and multiple system tauopathy with presenile dementia (MSTD) (Spillantini et al., 1997). These disorders are characterized by variable degrees of frontal lobe dementia, parkinsonism, motor neuron disease, and amyotrophy. Other neurodegenerative disorders associated with mutations in the MAPT gene include Pick disease (172700) and progressive supranuclear palsy (PSP; 601104). Inherited neurodegenerative tauopathies linked to chromosome 17 and caused by mutation in the MAPT gene have also collectively been termed 'FTDP17' (Lee et al., 2001). Kertesz (2003) suggested the term 'Pick complex' to represent the overlapping syndromes of FTD, primary progressive aphasia (PPA), corticobasal degeneration (CBD), PSP, and FTD with motor neuron disease. He noted that frontotemporal dementia may also be referred to as 'clinical Pick disease' and that the term 'Pick disease' should be restricted to the pathologic finding of Pick bodies. Genetic Heterogeneity of Frontotemporal Lobar Degeneration Mutations in several different genes can cause frontotemporal dementia and frontotemporal lobar degeneration, with or without motor neuron disease. See FTD2 (607485), caused by mutation in the GRN gene (138945) on chromosome 17q21; FTDALS7 (600795), caused by mutation in the CHMP2B gene (609512) on chromosome 3p11; inclusion body myopathy with Paget disease and FTD (IBMPFD; 167320), caused by mutation in the VCP gene (601023) on chromosome 9p13; ALS6 (608030), caused by mutation in the FUS gene (137070) on 16p11; ALS10 (612069), caused by mutation in the TARDBP gene (605078) on 1p36; and FTDALS1 (105550), caused by mutation in the C9ORF72 gene (614260) on 9p21. In 1 family with FTD, a mutation was identified in the presenilin-1 gene (PSEN1; 104311) on chromosome 14, which is usually associated with a familial form of early-onset Alzheimer disease (AD3; 607822).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/83266">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_337637"><div><strong>Spinocerebellar ataxia type 17</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>337637</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1846707</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Spinocerebellar ataxia type 17 (SCA17) is characterized by ataxia, dementia, and involuntary movements, including chorea and dystonia. Psychiatric symptoms, pyramidal signs, and rigidity are common. The age of onset ranges from three to 55 years. Individuals with full-penetrance alleles develop neurologic and/or psychiatric symptoms by age 50 years. Ataxia and psychiatric abnormalities are frequently the initial findings, followed by involuntary movement, parkinsonism, dementia, and pyramidal signs. Brain MRI shows variable atrophy of the cerebrum, brain stem, and cerebellum. The clinical features correlate with the length of the polyglutamine expansion but are not absolutely predictive of the clinical course.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/337637">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_863085"><div><strong>Frontotemporal dementia and/or amyotrophic lateral sclerosis 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>863085</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014648</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">CHCHD10-related disorders are characterized by a spectrum of adult-onset neurologic phenotypes that can include: Mitochondrial myopathy (may also be early onset): weakness, amyotrophy, exercise intolerance. Amyotrophic lateral sclerosis (ALS): progressive degeneration of upper motor neurons and lower motor neurons. Frontotemporal dementia (FTD): slowly progressive behavioral changes, language disturbances, cognitive decline, extrapyramidal signs. Late-onset spinal motor neuronopathy (SMA, Jokela type): weakness, cramps, and/or fasciculations; areflexia. Axonal Charcot-Marie-Tooth neuropathy: slowly progressive lower-leg muscle weakness and atrophy, small hand muscle weakness, loss of tendon reflexes, sensory abnormalities. Cerebellar ataxia: gait ataxia, kinetic ataxia (progressive loss of coordination of lower- and upper-limb movements), dysarthria/dysphagia, nystagmus, cerebellar oculomotor disorder. Because of the recent discovery of CHCHD10-related disorders and the limited number of affected individuals reported to date, the natural history of these disorders (except for SMAJ caused by the p.Gly66Val pathogenic variant) is largely unknown.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/863085">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1648386"><div><strong>Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1648386</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4721893</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is characterized by fractures (resulting from radiologically demonstrable polycystic osseous lesions), frontal lobe syndrome, and progressive presenile dementia beginning in the fourth decade. The clinical course of PLOSL can be divided into four stages: 1.. The latent stage is characterized by normal early development. 2.. The osseous stage (3rd decade of life) is characterized by pain and tenderness, mostly in ankles and feet, usually following strain or injury. Fractures are typically diagnosed several years later, most commonly in the bones of the extremities. 3.. In the early neurologic stage (4th decade of life), a change of personality begins to develop insidiously. Affected individuals show a frontal lobe syndrome (loss of judgment, euphoria, loss of social inhibitions, disturbance of concentration, and lack of insight, libido, and motor persistence) leading to serious social issues. 4.. The late neurologic stage is characterized by progressive dementia and loss of mobility. Death usually occurs before age 50 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1648386">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794139"><div><strong>Leukoencephalopathy, diffuse hereditary, with spheroids 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794139</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561929</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of CSF1R-related disorder ranges from early-onset disease (age <18 years) to late-onset disease (age =18 years). Early-onset disease is associated with hypotonia, delayed acquisition of developmental milestones, and non-neurologic manifestations (such as skeletal abnormalities); both early- and late-onset disease have similar neurodegenerative involvement. Most affected individuals eventually become bedridden with spasticity, rigidity, and loss of the ability to walk. They lose speech and voluntary movement and appear to be generally unaware of their surroundings. The last stage of disease progresses to a vegetative state with presence of primitive reflexes, such as visual and tactile grasp, mouth-opening reflex, and sucking reflex. Death most commonly results from pneumonia or other infections. About 500 individuals with CSF1R-related disorder have been reported to date.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794139">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_83266" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Frontotemporal dementia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_863085" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Frontotemporal dementia and/or amyotrophic lateral sclerosis 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794139" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Leukoencephalopathy, diffuse hereditary, with spheroids 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1648386" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_337637" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Spinocerebellar ataxia type 17</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/23482660">Frontal lobe dementia, motor neuron disease, and clinical and neuropathological criteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neary D,
|
||
Snowden J</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2013 Jul;84(7):713-4.
|
||
Epub 2013 Mar 12
|
||
doi: 10.1136/jnnp-2012-304549.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23482660" target="_blank">23482660</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11402150">Therapy and management of frontal lobe dementia patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Litvan I</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2001 Jun;56(11 Suppl 4):S41-5.
|
||
doi: 10.1212/wnl.56.suppl_4.s41.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11402150" target="_blank">11402150</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11310619">Primary progressive aphasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mesulam MM</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2001 Apr;49(4):425-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11310619" target="_blank">11310619</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22frontal%20lobe%20dementia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (9)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21887521">Extrapyramidal syndromes in frontotemporal degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
McMonagle P,
|
||
Jesso S</span><br />
|
||
<span class="medgenPMjournal">J Mol Neurosci</span>
|
||
2011 Nov;45(3):336-42.
|
||
Epub 2011 Sep 2
|
||
doi: 10.1007/s12031-011-9616-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21887521" target="_blank">21887521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11310619">Primary progressive aphasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mesulam MM</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2001 Apr;49(4):425-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11310619" target="_blank">11310619</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9634206">Amyotrophic lateral sclerosis: current issues in classification, pathogenesis and molecular pathology.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ince PG,
|
||
Lowe J,
|
||
Shaw PJ</span><br />
|
||
<span class="medgenPMjournal">Neuropathol Appl Neurobiol</span>
|
||
1998 Apr;24(2):104-17.
|
||
doi: 10.1046/j.1365-2990.1998.00108.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9634206" target="_blank">9634206</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9043744">Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Davidson W,
|
||
Fox H</span><br />
|
||
<span class="medgenPMjournal">Can J Neurol Sci</span>
|
||
1997 Feb;24(1):29-36.
|
||
doi: 10.1017/s0317167100021053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9043744" target="_blank">9043744</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3499484">Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neary D,
|
||
Snowden JS,
|
||
Shields RA,
|
||
Burjan AW,
|
||
Northen B,
|
||
MacDermott N,
|
||
Prescott MC,
|
||
Testa HJ</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
1987 Sep;50(9):1101-9.
|
||
doi: 10.1136/jnnp.50.9.1101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3499484" target="_blank">3499484</a><a href="/pmc/articles/PMC1032339" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontal%20lobe%20dementia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (42)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37379561">Frontotemporal dementia: Past, present, and future.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulugut H,
|
||
Pijnenburg YAL</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Dement</span>
|
||
2023 Nov;19(11):5253-5263.
|
||
Epub 2023 Jun 28
|
||
doi: 10.1002/alz.13363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37379561" target="_blank">37379561</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12168557">Frontotemporal dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Munoz DG</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2002 May;86(3):501-18, vi.
|
||
doi: 10.1016/s0025-7125(02)00011-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12168557" target="_blank">12168557</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11310619">Primary progressive aphasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mesulam MM</span><br />
|
||
<span class="medgenPMjournal">Ann Neurol</span>
|
||
2001 Apr;49(4):425-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11310619" target="_blank">11310619</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9059759">Primary progressive aphasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Munoz DG</span><br />
|
||
<span class="medgenPMjournal">Clin Neurosci</span>
|
||
1997;4(2):95-102.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9059759" target="_blank">9059759</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2294666">Frontal lobe dementia of non-Alzheimer type.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gustafson L,
|
||
Brun A,
|
||
Risberg J</span><br />
|
||
<span class="medgenPMjournal">Adv Neurol</span>
|
||
1990;51:65-71.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2294666" target="_blank">2294666</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontal%20lobe%20dementia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (73)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/12672175">Drug therapy of frontotemporal dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Allain H,
|
||
Bentué-Ferrer D,
|
||
Tribut O,
|
||
Mérienne M,
|
||
Belliard S</span><br />
|
||
<span class="medgenPMjournal">Hum Psychopharmacol</span>
|
||
2003 Apr;18(3):221-5.
|
||
doi: 10.1002/hup.472.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12672175" target="_blank">12672175</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11402150">Therapy and management of frontal lobe dementia patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Litvan I</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2001 Jun;56(11 Suppl 4):S41-5.
|
||
doi: 10.1212/wnl.56.suppl_4.s41.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11402150" target="_blank">11402150</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10689042">Planning impairments in frontal lobe dementia and frontal lobe lesion patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carlin D,
|
||
Bonerba J,
|
||
Phipps M,
|
||
Alexander G,
|
||
Shapiro M,
|
||
Grafman J</span><br />
|
||
<span class="medgenPMjournal">Neuropsychologia</span>
|
||
2000;38(5):655-65.
|
||
doi: 10.1016/s0028-3932(99)00102-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10689042" target="_blank">10689042</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9043744">Frontal behavioral inventory: diagnostic criteria for frontal lobe dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Davidson W,
|
||
Fox H</span><br />
|
||
<span class="medgenPMjournal">Can J Neurol Sci</span>
|
||
1997 Feb;24(1):29-36.
|
||
doi: 10.1017/s0317167100021053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9043744" target="_blank">9043744</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7580195">Rapidly progressive frontal-type dementia associated with Lyme disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Waniek C,
|
||
Prohovnik I,
|
||
Kaufman MA,
|
||
Dwork AJ</span><br />
|
||
<span class="medgenPMjournal">J Neuropsychiatry Clin Neurosci</span>
|
||
1995 Summer;7(3):345-7.
|
||
doi: 10.1176/jnp.7.3.345.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7580195" target="_blank">7580195</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontal%20lobe%20dementia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37379561">Frontotemporal dementia: Past, present, and future.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulugut H,
|
||
Pijnenburg YAL</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Dement</span>
|
||
2023 Nov;19(11):5253-5263.
|
||
Epub 2023 Jun 28
|
||
doi: 10.1002/alz.13363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37379561" target="_blank">37379561</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21887521">Extrapyramidal syndromes in frontotemporal degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
McMonagle P,
|
||
Jesso S</span><br />
|
||
<span class="medgenPMjournal">J Mol Neurosci</span>
|
||
2011 Nov;45(3):336-42.
|
||
Epub 2011 Sep 2
|
||
doi: 10.1007/s12031-011-9616-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21887521" target="_blank">21887521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10581380">A multiparametric MRI study of frontal lobe dementia in multiple sclerosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Comi G,
|
||
Rovaris M,
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||
Falautano M,
|
||
Santuccio G,
|
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Martinelli V,
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Rocca MA,
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Possa F,
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Leocani L,
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Paulesu E,
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1999 Dec 15;171(2):135-44.
|
||
doi: 10.1016/s0022-510x(99)00266-x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10581380" target="_blank">10581380</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10436340">Clinical and pathological overlap between frontotemporal dementia, primary progressive aphasia and corticobasal degeneration: the Pick complex.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Davidson W,
|
||
Munoz DG</span><br />
|
||
<span class="medgenPMjournal">Dement Geriatr Cogn Disord</span>
|
||
1999;10 Suppl 1:46-9.
|
||
doi: 10.1159/000051212.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10436340" target="_blank">10436340</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9700660">Combination of the different biological markers for increasing specificity of in vivo Alzheimer's testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Blennow K,
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Vanmechelen E</span><br />
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<span class="medgenPMjournal">J Neural Transm Suppl</span>
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1998;53:223-35.
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||
doi: 10.1007/978-3-7091-6467-9_20.
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<span class="bold">PMID: </span><a href="/pubmed/9700660" target="_blank">9700660</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontal%20lobe%20dementia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (18)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37379561">Frontotemporal dementia: Past, present, and future.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ulugut H,
|
||
Pijnenburg YAL</span><br />
|
||
<span class="medgenPMjournal">Alzheimers Dement</span>
|
||
2023 Nov;19(11):5253-5263.
|
||
Epub 2023 Jun 28
|
||
doi: 10.1002/alz.13363.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37379561" target="_blank">37379561</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36328774">Symptomatology and Neuropathology of patients presenting with focal cortical signs.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ishihara K,
|
||
Fukui T,
|
||
Kawamura M,
|
||
Shiota JI,
|
||
Nakano I</span><br />
|
||
<span class="medgenPMjournal">Neuropathology</span>
|
||
2023 Feb;43(1):27-43.
|
||
Epub 2022 Nov 3
|
||
doi: 10.1111/neup.12854.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36328774" target="_blank">36328774</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21887521">Extrapyramidal syndromes in frontotemporal degeneration.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
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||
McMonagle P,
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||
Jesso S</span><br />
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||
<span class="medgenPMjournal">J Mol Neurosci</span>
|
||
2011 Nov;45(3):336-42.
|
||
Epub 2011 Sep 2
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||
doi: 10.1007/s12031-011-9616-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21887521" target="_blank">21887521</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10436340">Clinical and pathological overlap between frontotemporal dementia, primary progressive aphasia and corticobasal degeneration: the Pick complex.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kertesz A,
|
||
Davidson W,
|
||
Munoz DG</span><br />
|
||
<span class="medgenPMjournal">Dement Geriatr Cogn Disord</span>
|
||
1999;10 Suppl 1:46-9.
|
||
doi: 10.1159/000051212.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10436340" target="_blank">10436340</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3499484">Single photon emission tomography using 99mTc-HM-PAO in the investigation of dementia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Neary D,
|
||
Snowden JS,
|
||
Shields RA,
|
||
Burjan AW,
|
||
Northen B,
|
||
MacDermott N,
|
||
Prescott MC,
|
||
Testa HJ</span><br />
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||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
1987 Sep;50(9):1101-9.
|
||
doi: 10.1136/jnnp.50.9.1101.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3499484" target="_blank">3499484</a><a href="/pmc/articles/PMC1032339" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frontal%20lobe%20dementia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div></div>
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