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<meta name="keywords" content="C0151517, atrioventricular block complete, atrioventricular block, third degree, av block third degree, chb - complete heart block, complete atrioventricular block, complete av block, complete heart block, disease or syndrome, high grade atrioventricular block, non-congenital complete atrioventricular block, third degree atrioventricular block, third degree av block, third degree heart block, third-degree atrioventricular block, third-degree heart block, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=56230
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ConceptID=C0151517
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Third degree atrioventricular block</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>56230</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0151517</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Complete heart block</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>High grade atrioventricular block (27885002); Complete atrioventricular block (27885002); Third degree atrioventricular block (27885002); Third degree heart block (27885002); Complete heart block (27885002); CHB - Complete heart block (27885002)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001709">HP:0001709</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0000468" target="_blank">MONDO:0000468</a></td></tr>
|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_content ln">Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Third degree atrioventricular block</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/116727" ref="tree=MeSH" title="MedGen record for Abnormality of the cardiovascular system">Abnormality of the cardiovascular system</a></span><ul><li><span class="TLline"><a href="/medgen/869166" ref="tree=MeSH" title="MedGen record for Abnormal cardiovascular system physiology">Abnormal cardiovascular system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/1393551" ref="tree=MeSH" title="MedGen record for Abnormality of cardiovascular system electrophysiology">Abnormality of cardiovascular system electrophysiology</a></span><ul><li><span class="TLline"><a href="/medgen/2039" ref="tree=MeSH" title="MedGen record for Cardiac arrhythmia">Cardiac arrhythmia</a></span><ul><li><span class="TLline"><a href="/medgen/42363" ref="tree=MeSH" title="MedGen record for Heart block">Heart block</a></span><ul><li><span class="TLline"><a href="/medgen/13956" ref="tree=MeSH" title="MedGen record for Atrioventricular block">Atrioventricular block</a></span><ul><li><span class="matched_ds">Third degree atrioventricular block</span><ul><li><span class="TLline"><a href="/medgen/1391206" ref="tree=MeSH" title="MedGen record for Complete heart block with broad QRS complexes">Complete heart block with broad QRS complexes</a></span></li><li><span class="TLline"><a href="/medgen/331099" ref="tree=MeSH" title="MedGen record for Complete heart block with narrow QRS complexes">Complete heart block with narrow QRS complexes</a></span></li><li><span class="TLline"><a href="/medgen/473062" ref="tree=MeSH" title="MedGen record for Congenital complete atrioventricular heart block">Congenital complete atrioventricular heart block</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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||
<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_9618"><div><strong>Kearns-Sayre syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9618</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022541</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Single large-scale mitochondrial DNA deletion syndromes (SLSMDSs) comprise overlapping clinical phenotypes including Kearns-Sayre syndrome (KSS), KSS spectrum, Pearson syndrome (PS), chronic progressive external ophthalmoplegia (CPEO), and CPEO-plus. KSS is a progressive multisystem disorder with onset before age 20 years characterized by pigmentary retinopathy, CPEO, and cardiac conduction abnormality. Additional features can include cerebellar ataxia, tremor, intellectual disability or cognitive decline, dementia, sensorineural hearing loss, oropharyngeal and esophageal dysfunction, exercise intolerance, muscle weakness, and endocrinopathies. Brain imaging typically shows bilateral lesions in the globus pallidus and white matter. KSS spectrum includes individuals with KSS in addition to individuals with ptosis and/or ophthalmoparesis and at least one of the following: retinopathy, ataxia, cardiac conduction defects, hearing loss, growth deficiency, cognitive impairment, tremor, or cardiomyopathy. Compared to CPEO-plus, individuals with KSS spectrum have more severe muscle involvement (e.g., weakness, atrophy) and overall have a worse prognosis. PS is characterized by pancytopenia (typically transfusion-dependent sideroblastic anemia with variable cell line involvement), exocrine pancreatic dysfunction, poor weight gain, and lactic acidosis. PS manifestations also include renal tubular acidosis, short stature, and elevated liver enzymes. PS may be fatal in infancy due to neutropenia-related infection or refractory metabolic acidosis. CPEO is characterized by ptosis, ophthalmoplegia, oropharyngeal weakness, variable proximal limb weakness, and/or exercise intolerance. CPEO-plus includes CPEO with additional multisystemic involvement including neuropathy, diabetes mellitus, migraines, hypothyroidism, neuropsychiatric manifestations, and optic neuropathy. Rarely, an SLSMDS can manifest as Leigh syndrome, which is characterized as developmental delays, neurodevelopmental regression, lactic acidosis, and bilateral symmetric basal ganglia, brain stem, and/or midbrain lesions on MRI.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9618">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_120524"><div><strong>Holt-Oram syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>120524</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0265264</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Holt-Oram syndrome (HOS) is characterized by upper-limb defects, congenital heart malformation, and cardiac conduction disease. Upper-limb malformations may be unilateral, bilateral/symmetric, or bilateral/asymmetric and can range from triphalangeal or absent thumb(s) to phocomelia. Other upper-limb malformations can include unequal arm length caused by aplasia or hypoplasia of the radius, fusion or anomalous development of the carpal and thenar bones, abnormal forearm pronation and supination, abnormal opposition of the thumb, sloping shoulders, and restriction of shoulder joint movement. An abnormal carpal bone is present in all affected individuals and may be the only evidence of disease. A congenital heart malformation is present in 75% of individuals with HOS and most commonly involves the septum. Atrial septal defect and ventricular septal defect can vary in number, size, and location. Complex congenital heart malformations can also occur in individuals with HOS. Individuals with HOS with or without a congenital heart malformation are at risk for cardiac conduction disease. While individuals may present at birth with sinus bradycardia and first-degree atrioventricular (AV) block, AV block can progress unpredictably to a higher grade including complete heart block with and without atrial fibrillation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/120524">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_258500"><div><strong>Dilated cardiomyopathy 1A</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>258500</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1449563</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">LMNA-related dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and/or reduced systolic function preceded (sometimes by many years) by or accompanied by conduction system disease and/or arrhythmias. LMNA-related DCM usually presents in early to mid-adulthood with symptomatic conduction system disease or arrhythmias, or with symptomatic DCM including heart failure or embolus from a left ventricular mural thrombus. Sudden cardiac death can occur, and in some instances is the presenting manifestation; sudden cardiac death may occur with minimal or no systolic dysfunction.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/258500">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_330449"><div><strong>Desmin-related myofibrillar myopathy</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>330449</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832370</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Myofibrillar myopathy (MFM) is a noncommittal term that refers to a group of morphologically homogeneous, but genetically heterogeneous chronic neuromuscular disorders. The morphologic changes in skeletal muscle in MFM result from disintegration of the sarcomeric Z disc and the myofibrils, followed by abnormal ectopic accumulation of multiple proteins involved in the structure of the Z disc, including desmin, alpha-B-crystallin (CRYAB; 123590), dystrophin (300377), and myotilin (TTID; 604103). Genetic Heterogeneity of Myofibrillar Myopathy Other forms of MFM include MFM2 (608810), caused by mutation in the CRYAB gene (123590); MFM3 (609200), caused by mutation in the MYOT gene (604103); MFM4 (609452), caused by mutation in the ZASP gene (LDB3; 605906); MFM5 (609524), caused by mutation in the FLNC gene (102565); MFM6 (612954), caused by mutation in the BAG3 gene (603883); MFM7 (617114), caused by mutation in the KY gene (605739); MFM8 (617258), caused by mutation in the PYROXD1 gene (617220); MFM9 (603689), caused by mutation in the TTN gene (188840); MFM10 (619040), caused by mutation in the SVIL UNC45B gene (611220); MFM11 (619178), caused by mutation in the UNC45B gene (611220); MFM12 (619424), caused by mutation in the MYL2 gene (160781); and MFM13 (621078), caused by mutation in the HSPB8 gene (608014). 'Desmin-related myopathy' is another term referring to MFM in which there are intrasarcoplasmic aggregates of desmin, usually in addition to other sarcomeric proteins. Rigid spine syndrome (602771), caused by mutation in the SEPN1 gene (606210), is another desmin-related myopathy. Goebel (1995) provided a review of desmin-related myopathy.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/330449">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_934603"><div><strong>Atrial fibrillation, familial, 18</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>934603</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4310636</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial atrial fibrillation is an inherited abnormality of the heart's normal rhythm. Atrial fibrillation is characterized by episodes of uncoordinated electrical activity (fibrillation) in the heart's upper chambers (the atria), which cause a fast and irregular heartbeat. If untreated, this abnormal heart rhythm (arrhythmia) can lead to dizziness, chest pain, a sensation of fluttering or pounding in the chest (palpitations), shortness of breath, or fainting (syncope). Atrial fibrillation also increases the risk of stroke and sudden death. Complications of atrial fibrillation can occur at any age, although some people with this heart condition never experience any health problems associated with the disorder.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/934603">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1631694"><div><strong>LEOPARD syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1631694</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551484</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Noonan syndrome with multiple lentigines (NSML) is a condition in which the cardinal features consist of lentigines, hypertrophic cardiomyopathy, short stature, pectus deformity, and dysmorphic facial features including widely spaced eyes and ptosis. Multiple lentigines present as dispersed flat, black-brown macules, mostly on the face, neck, and upper part of the trunk with sparing of the mucosa. In general, lentigines do not appear until age four to five years but then increase to the thousands by puberty. Some individuals with NSML do not exhibit lentigines. Approximately 85% of affected individuals have heart defects, including hypertrophic cardiomyopathy (typically appearing during infancy and sometimes progressive) and pulmonary valve stenosis. Postnatal growth restriction resulting in short stature occurs in fewer than 50% of affected persons, although most affected individuals have a height that is less than the 25th centile for age. Sensorineural hearing deficits, present in approximately 20% of affected individuals, are poorly characterized. Intellectual disability, typically mild, is observed in approximately 30% of persons with NSML.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1631694">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794238"><div><strong>Acromesomelic dysplasia 4</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794238</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562028</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Acromesomelic dysplasia-4 (AMD4) is characterized by disproportionate short stature due to mesomelic shortening of the limbs. Radiographic hallmarks include mild to moderate platyspondyly, moderate brachydactyly, iliac flaring, and metaphyseal alterations of the long bones that progressively increase with age (Diaz-Gonzalez et al., 2022). For a discussion of genetic heterogeneity of acromesomelic dysplasia, see AMD1 (602875).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794238">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794280"><div><strong>Immunodeficiency 87 and autoimmunity</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794280</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5562070</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Immunodeficiency-87 and autoimmunity (IMD87) is an autosomal recessive immunologic disorder with wide phenotypic variation and severity. Affected individuals usually present in infancy or early childhood with increased susceptibility to infections, often Epstein-Barr virus (EBV), as well as with lymphadenopathy or autoimmune manifestations, predominantly hemolytic anemia. Laboratory studies may show low or normal lymphocyte numbers, often with skewed T-cell subset ratios. The disorder results primarily from defects in T-cell function, which causes both immunodeficiency and overall immune dysregulation (summary by Serwas et al., 2019 and Fournier et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794280">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1805172"><div><strong>Developmental and epileptic encephalopathy 101</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1805172</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5676955</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Developmental and epileptic encephalopathy-101 (DEE101) is a severe autosomal recessive disorder characterized by early infantile epileptic encephalopathy and severe global developmental delay (summary by Blakes et al., 2022). For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1805172">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794238" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acromesomelic dysplasia 4</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_934603" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrial fibrillation, familial, 18</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_330449" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Desmin-related myofibrillar myopathy</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1805172" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Developmental and epileptic encephalopathy 101</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_258500" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Dilated cardiomyopathy 1A</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_120524" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Holt-Oram syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794280" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Immunodeficiency 87 and autoimmunity</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9618" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Kearns-Sayre syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1631694" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">LEOPARD syndrome 1</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39382277">Impact of early detection and steroid treatment on fetal ventricular heart rate and pacemaker implantation in anti-Ro/SSA positive congenital heart block.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sonesson SE,
|
||
Ambrosi A,
|
||
Nordenstam F,
|
||
Eliasson H,
|
||
Wahren-Herlenius M</span><br />
|
||
<span class="medgenPMjournal">Acta Obstet Gynecol Scand</span>
|
||
2024 Dec;103(12):2433-2441.
|
||
Epub 2024 Oct 9
|
||
doi: 10.1111/aogs.14988.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39382277" target="_blank">39382277</a><a href="/pmc/articles/PMC11609981" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35001672">Outcome of Antibody-Mediated Fetal Heart Disease With Standardized Anti-Inflammatory Transplacental Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mawad W,
|
||
Hornberger L,
|
||
Cuneo B,
|
||
Raboisson MJ,
|
||
Moon-Grady AJ,
|
||
Lougheed J,
|
||
Diab K,
|
||
Parkman J,
|
||
Silverman E,
|
||
Jaeggi E</span><br />
|
||
<span class="medgenPMjournal">J Am Heart Assoc</span>
|
||
2022 Feb;11(3):e023000.
|
||
Epub 2022 Jan 8
|
||
doi: 10.1161/JAHA.121.023000.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35001672" target="_blank">35001672</a><a href="/pmc/articles/PMC9238501" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7661495">Theophylline for the treatment of atrioventricular block after myocardial infarction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bertolet BD,
|
||
McMurtrie EB,
|
||
Hill JA,
|
||
Belardinelli L</span><br />
|
||
<span class="medgenPMjournal">Ann Intern Med</span>
|
||
1995 Oct 1;123(7):509-11.
|
||
doi: 10.7326/0003-4819-123-7-199510010-00006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7661495" target="_blank">7661495</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22third%20degree%20atrioventricular%20block%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (8)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38587241">Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yndigegn T,
|
||
Lindahl B,
|
||
Mars K,
|
||
Alfredsson J,
|
||
Benatar J,
|
||
Brandin L,
|
||
Erlinge D,
|
||
Hallen O,
|
||
Held C,
|
||
Hjalmarsson P,
|
||
Johansson P,
|
||
Karlström P,
|
||
Kellerth T,
|
||
Marandi T,
|
||
Ravn-Fischer A,
|
||
Sundström J,
|
||
Östlund O,
|
||
Hofmann R,
|
||
Jernberg T;
|
||
REDUCE-AMI Investigators</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2024 Apr 18;390(15):1372-1381.
|
||
Epub 2024 Apr 7
|
||
doi: 10.1056/NEJMoa2401479.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38587241" target="_blank">38587241</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38568602">Risk of Cardiac Arrhythmias Among Climbers on Mount Everest.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sherpa K,
|
||
Sherpa PP,
|
||
Sherpa T,
|
||
Rothenbühler M,
|
||
Ryffel C,
|
||
Sherpa D,
|
||
Sherpa DR,
|
||
Sherchand O,
|
||
Galuszka O,
|
||
Dernektsi C,
|
||
Reichlin T,
|
||
Pilgrim T</span><br />
|
||
<span class="medgenPMjournal">JAMA Cardiol</span>
|
||
2024 May 1;9(5):480-485.
|
||
doi: 10.1001/jamacardio.2024.0364.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38568602" target="_blank">38568602</a><a href="/pmc/articles/PMC10993151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31492651">Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Comi G,
|
||
Kappos L,
|
||
Selmaj KW,
|
||
Bar-Or A,
|
||
Arnold DL,
|
||
Steinman L,
|
||
Hartung HP,
|
||
Montalban X,
|
||
Kubala Havrdová E,
|
||
Cree BAC,
|
||
Sheffield JK,
|
||
Minton N,
|
||
Raghupathi K,
|
||
Ding N,
|
||
Cohen JA;
|
||
SUNBEAM Study Investigators</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2019 Nov;18(11):1009-1020.
|
||
Epub 2019 Sep 3
|
||
doi: 10.1016/S1474-4422(19)30239-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31492651" target="_blank">31492651</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29893417">Inadvertent pacemaker lead dislodgement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Eulert-Grehn JJ,
|
||
Schmidt G,
|
||
Kempfert J,
|
||
Starck C</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Sep;41(9):1266-1267.
|
||
Epub 2018 Jul 11
|
||
doi: 10.1111/pace.13412.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29893417" target="_blank">29893417</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1615742">Permanent cardiac pacing for prolonged second and third degree atrioventricular block complicating cardiac valve replacement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zakhia Doueihi R,
|
||
Leloux MF,
|
||
De Roy L,
|
||
Krémer R</span><br />
|
||
<span class="medgenPMjournal">Acta Cardiol</span>
|
||
1992;47(2):157-66.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1615742" target="_blank">1615742</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (191)</a></div><h3 class="subhead">Diagnosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38587241">Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yndigegn T,
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Johansson P,
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Karlström P,
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Kellerth T,
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Marandi T,
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Ravn-Fischer A,
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Sundström J,
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Östlund O,
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Hofmann R,
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Jernberg T;
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REDUCE-AMI Investigators</span><br />
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2024 Apr 18;390(15):1372-1381.
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<span class="bold">PMID: </span><a href="/pubmed/38587241" target="_blank">38587241</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37321683">Electrocardiography of Atrioventricular Block.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Clark BA,
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Prystowsky EN</span><br />
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2023 Aug;41(3):307-313.
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doi: 10.1016/j.ccl.2023.03.007.
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<span class="bold">PMID: </span><a href="/pubmed/37321683" target="_blank">37321683</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34689889">Electrocardiography of Atrioventricular Block.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Clark BA,
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Prystowsky EN</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/34689889" target="_blank">34689889</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34599493">Syncope due to third-degree atrioventricular block as the only manifestation of myocarditis following COVID-19 infection.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wojewoda K,
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<span class="bold">PMID: </span><a href="/pubmed/34599493" target="_blank">34599493</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28204445">Third-degree atrioventricular block: tip of the iceberg of a systemic disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bacanovic S,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (170)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38587241">Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yndigegn T,
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Lindahl B,
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Mars K,
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Alfredsson J,
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Benatar J,
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Brandin L,
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Erlinge D,
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Hallen O,
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Held C,
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Hjalmarsson P,
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Johansson P,
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Karlström P,
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Kellerth T,
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Marandi T,
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Ravn-Fischer A,
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Sundström J,
|
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Östlund O,
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Hofmann R,
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Jernberg T;
|
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REDUCE-AMI Investigators</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2024 Apr 18;390(15):1372-1381.
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Epub 2024 Apr 7
|
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doi: 10.1056/NEJMoa2401479.
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<span class="bold">PMID: </span><a href="/pubmed/38587241" target="_blank">38587241</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/37192262">Third-Degree Atrioventricular Block With High-Dose Lamotrigine Use.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">İzci F,
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İzci S</span><br />
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<span class="medgenPMjournal">Prim Care Companion CNS Disord</span>
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2023 May 11;25(3)
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<span class="bold">PMID: </span><a href="/pubmed/37192262" target="_blank">37192262</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36302470">Third-degree atrioventricular block associated with the SARS-CoV-2 mRNA vaccine.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pons-Riverola A,
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Mañas P,
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Claver E,
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Meroño O,
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Anguera I</span><br />
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<span class="medgenPMjournal">Rev Esp Cardiol (Engl Ed)</span>
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2023 May;76(5):384-386.
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Epub 2022 Oct 24
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doi: 10.1016/j.rec.2022.10.004.
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<span class="bold">PMID: </span><a href="/pubmed/36302470" target="_blank">36302470</a><a href="/pmc/articles/PMC9595393" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/31492651">Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Comi G,
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Kappos L,
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Selmaj KW,
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Bar-Or A,
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Arnold DL,
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Steinman L,
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Hartung HP,
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Montalban X,
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Kubala Havrdová E,
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Cree BAC,
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Sheffield JK,
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Minton N,
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Raghupathi K,
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Ding N,
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Cohen JA;
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SUNBEAM Study Investigators</span><br />
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<span class="medgenPMjournal">Lancet Neurol</span>
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2019 Nov;18(11):1009-1020.
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Epub 2019 Sep 3
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doi: 10.1016/S1474-4422(19)30239-X.
|
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<span class="bold">PMID: </span><a href="/pubmed/31492651" target="_blank">31492651</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29893417">Inadvertent pacemaker lead dislodgement.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Eulert-Grehn JJ,
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Schmidt G,
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2018 Sep;41(9):1266-1267.
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<span class="bold">PMID: </span><a href="/pubmed/29893417" target="_blank">29893417</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (139)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38758069">Pre-eclampsia and long-term risk of arrhythmias.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Havers-Borgersen E,
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Stahl A,
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Johansen M,
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Fosbøl EL</span><br />
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<span class="medgenPMjournal">Eur J Prev Cardiol</span>
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2024 Sep 20;31(13):1621-1630.
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doi: 10.1093/eurjpc/zwae176.
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<span class="bold">PMID: </span><a href="/pubmed/38758069" target="_blank">38758069</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38568602">Risk of Cardiac Arrhythmias Among Climbers on Mount Everest.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sherpa K,
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Sherpa PP,
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doi: 10.1001/jamacardio.2024.0364.
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<span class="bold">PMID: </span><a href="/pubmed/38568602" target="_blank">38568602</a><a href="/pmc/articles/PMC10993151" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/10447229">The prevalence and prognosis of third-degree atrioventricular conduction block: the Reykjavik study.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kojic EM,
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<div class="nl"><a target="_blank" href="/pubmed/1615742">Permanent cardiac pacing for prolonged second and third degree atrioventricular block complicating cardiac valve replacement.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zakhia Doueihi R,
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<div class="nl"><a target="_blank" href="/pubmed/2026992">Third-degree atrioventricular block in an athlete.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Hernández-Madrid A,
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Moro C,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (124)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39028996">Smartwatch-Detected Arrhythmias in Patients After Transcatheter Aortic Valve Replacement (TAVR): Analysis of the SMART TAVR Trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fan J,
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<span class="bold">PMID: </span><a href="/pubmed/39028996" target="_blank">39028996</a><a href="/pmc/articles/PMC11297386" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/38758069">Pre-eclampsia and long-term risk of arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Havers-Borgersen E,
|
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Stahl A,
|
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Johansen M,
|
||
Jøns C,
|
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Køber L,
|
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Fosbøl EL</span><br />
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<span class="medgenPMjournal">Eur J Prev Cardiol</span>
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2024 Sep 20;31(13):1621-1630.
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doi: 10.1093/eurjpc/zwae176.
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<span class="bold">PMID: </span><a href="/pubmed/38758069" target="_blank">38758069</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35526016">Rare and potential pathogenic mutations of LMNA and LAMA4 associated with familial arrhythmogenic right ventricular cardiomyopathy/dysplasia with right ventricular heart failure, cerebral thromboembolism and hereditary electrocardiogram abnormality.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chen J,
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Ma Y,
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Li H,
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Lin Z,
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Yang Z,
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Zhang Q,
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Wang F,
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Lin Y,
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Ye Z,
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Lin Y</span><br />
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2022 May 7;17(1):183.
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doi: 10.1186/s13023-022-02348-z.
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<span class="bold">PMID: </span><a href="/pubmed/35526016" target="_blank">35526016</a><a href="/pmc/articles/PMC9077868" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32267189">The association of cannabis use and cardiac dysrhythmias: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Richards JR,
|
||
Blohm E,
|
||
Toles KA,
|
||
Jarman AF,
|
||
Ely DF,
|
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Elder JW</span><br />
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<span class="medgenPMjournal">Clin Toxicol (Phila)</span>
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2020 Sep;58(9):861-869.
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Epub 2020 Apr 8
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doi: 10.1080/15563650.2020.1743847.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32267189" target="_blank">32267189</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31492651">Safety and efficacy of ozanimod versus interferon beta-1a in relapsing multiple sclerosis (SUNBEAM): a multicentre, randomised, minimum 12-month, phase 3 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Comi G,
|
||
Kappos L,
|
||
Selmaj KW,
|
||
Bar-Or A,
|
||
Arnold DL,
|
||
Steinman L,
|
||
Hartung HP,
|
||
Montalban X,
|
||
Kubala Havrdová E,
|
||
Cree BAC,
|
||
Sheffield JK,
|
||
Minton N,
|
||
Raghupathi K,
|
||
Ding N,
|
||
Cohen JA;
|
||
SUNBEAM Study Investigators</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2019 Nov;18(11):1009-1020.
|
||
Epub 2019 Sep 3
|
||
doi: 10.1016/S1474-4422(19)30239-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31492651" target="_blank">31492651</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (105)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36856589">Arrhythmias Beyond Atrial Fibrillation Detection Using Smartwatches: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pay L,
|
||
Yumurtaş AÇ,
|
||
Satti DI,
|
||
Hui JMH,
|
||
Chan JSK,
|
||
Mahalwar G,
|
||
Lee YHA,
|
||
Tezen O,
|
||
Birdal O,
|
||
Inan D,
|
||
Özkan E,
|
||
Tse G,
|
||
Çinier G</span><br />
|
||
<span class="medgenPMjournal">Anatol J Cardiol</span>
|
||
2023 Mar;27(3):126-131.
|
||
doi: 10.14744/AnatolJCardiol.2023.2799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36856589" target="_blank">36856589</a><a href="/pmc/articles/PMC9995551" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32267189">The association of cannabis use and cardiac dysrhythmias: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Richards JR,
|
||
Blohm E,
|
||
Toles KA,
|
||
Jarman AF,
|
||
Ely DF,
|
||
Elder JW</span><br />
|
||
<span class="medgenPMjournal">Clin Toxicol (Phila)</span>
|
||
2020 Sep;58(9):861-869.
|
||
Epub 2020 Apr 8
|
||
doi: 10.1080/15563650.2020.1743847.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32267189" target="_blank">32267189</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Third%20degree%20atrioventricular%20block%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
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|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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