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<!--
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UID=488909
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ConceptID=C0520933
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Abnormal spermatogenesis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>488909</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0520933</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding; Finding; Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Impaired spermatogenesis</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Abnormal spermatogenesis (4529005)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0008669">HP:0008669</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Incomplete maturation or aberrant formation of the male gametes. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Abnormal spermatogenesis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/474891" ref="tree=MeSH" title="MedGen record for Congenital Systemic Disorder">Congenital Systemic Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/52948" ref="tree=MeSH" title="MedGen record for Abnormality of the genitourinary system">Abnormality of the genitourinary system</a></span><ul><li><span class="TLline"><a href="/medgen/155422" ref="tree=MeSH" title="MedGen record for Abnormality of the genital system">Abnormality of the genital system</a></span><ul><li><span class="TLline"><a href="/medgen/892582" ref="tree=MeSH" title="MedGen record for Abnormality of reproductive system physiology">Abnormality of reproductive system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/866472" ref="tree=MeSH" title="MedGen record for Abnormal male reproductive system physiology">Abnormal male reproductive system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/871400" ref="tree=MeSH" title="MedGen record for Functional abnormality of male internal genitalia">Functional abnormality of male internal genitalia</a></span><ul><li><span class="matched_ds">Abnormal spermatogenesis</span><ul><li><span class="TLline"><a href="/medgen/2150" ref="tree=MeSH" title="MedGen record for Azoospermia">Azoospermia</a></span><ul><li><span class="TLline"><a href="/medgen/866757" ref="tree=MeSH" title="MedGen record for Non-obstructive azoospermia">Non-obstructive azoospermia</a></span><ul><li><span class="TLline"><a href="/medgen/1841619" ref="tree=MeSH" title="MedGen record for Spermiation failure">Spermiation failure</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/868703" ref="tree=MeSH" title="MedGen record for Obstructive azoospermia">Obstructive azoospermia</a></span></li><li><span class="TLline"><a href="/medgen/868702" ref="tree=MeSH" title="MedGen record for Pretesticular azoospermia">Pretesticular azoospermia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/889565" ref="tree=MeSH" title="MedGen record for Hypospermatogenesis">Hypospermatogenesis</a></span></li><li><span class="TLline"><a href="/medgen/678638" ref="tree=MeSH" title="MedGen record for Oligozoospermia">Oligozoospermia</a></span><ul><li><span class="TLline"><a href="/medgen/481180" ref="tree=MeSH" title="MedGen record for Cryptozoospermia">Cryptozoospermia</a></span></li><li><span class="TLline"><a href="/medgen/1841778" ref="tree=MeSH" title="MedGen record for Extreme oligozoospermia">Extreme oligozoospermia</a></span></li><li><span class="TLline"><a href="/medgen/896812" ref="tree=MeSH" title="MedGen record for Mild oligozoospermia">Mild oligozoospermia</a></span></li><li><span class="TLline"><a href="/medgen/1841781" ref="tree=MeSH" title="MedGen record for Moderate oligozoospermia">Moderate oligozoospermia</a></span></li><li><span class="TLline"><a href="/medgen/1640724" ref="tree=MeSH" title="MedGen record for Severe oligozoospermia">Severe oligozoospermia</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1374029" ref="tree=MeSH" title="MedGen record for Spermatogenesis maturation arrest">Spermatogenesis maturation arrest</a></span><ul><li><span class="TLline"><a href="/medgen/1386128" ref="tree=MeSH" title="MedGen record for Round spermatid arrest">Round spermatid arrest</a></span></li><li><span class="TLline"><a href="/medgen/1372736" ref="tree=MeSH" title="MedGen record for Spermatocyte maturation arrest">Spermatocyte maturation arrest</a></span></li><li><span class="TLline"><a href="/medgen/1853186" ref="tree=MeSH" title="MedGen record for Spermatogonial maturation arrest">Spermatogonial maturation arrest</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_439"><div><strong>Ataxia-telangiectasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>439</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0004135</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The phenotypic spectrum of ataxia-telangiectasia (A-T), a multisystem disorder, is a continuum ranging from classic A-T at the severe end and variant A-T at the milder end. Nonetheless, distinguishing between classic A-T and variant A-T on this spectrum helps understand differences in disease course, rate of progression, and life expectancy. Classic A-T is characterized by childhood onset of progressive neurologic manifestations (initially cerebellar ataxia, followed typically by extrapyramidal involvement and peripheral sensorimotor neuropathy), immunodeficiency (variably associated with abnormalities of humoral immunity, cellular immunity, or combined immune deficiency), pulmonary disease (resulting from recurrent infections, immune deficiency, aspiration, interstitial lung disease, and neurologic abnormalities), and increased risk of malignancy. Although it is generally accepted that intellectual disability is not common in A-T, disturbances in cerebellar as well as non-cerebellar brain areas and networks may result in cognitive deficits. Increased sensitivity to ionizing radiation (x-ray and gamma ray) can result in severe side effects from such treatments. Life expectancy is significantly reduced due to cancer, pulmonary disease, and infections. Variant A-T has a significantly milder disease course. While cerebellar ataxia can be absent, extrapyramidal movement disorders are common (typically dystonia and dystonic tremor) and most individuals have manifestations of axonal sensorimotor polyneuropathy. In contrast to classic A-T, immune function is generally normal, respiratory infections are not increased, and pulmonary disease is not a major feature. However, risk of developing malignancies is increased, particularly in premenopausal females who have an increased risk of developing breast cancer and hematologic malignancies.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/439">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82881"><div><strong>Isolated lutropin deficiency</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82881</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0271582</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Male patients with hypogonadotropic hypogonadism due to isolated luteinizing hormone (LH) deficiency have normal sexual differentiation but fail to develop spontaneous puberty. Absence of LH alters Leydig cell proliferation and maturation and impairs the onset of normal spermatogenesis, which requires high levels of intratesticular testosterone. Infertility and very low levels of spermatogenesis generally persist in affected men despite long-term exposure to gonadotropin therapy. Female patients exhibit normal pubertal development and menarche, followed by oligomenorrhea and anovulatory secondary amenorrhea (summary by Basciani et al., 2012). Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).' For a general phenotypic description and discussion of genetic heterogeneity of hypogonadotropic hypogonadism, see 147950. Reviews Arnhold et al. (2009) noted that the clinical manifestations of female patients with hypogonadotropic hypogonadism due to mutations in LHB are very similar to those of women with hypergonadotropic hypogonadism due to inactivating mutations of the LH receptor (see 238320): all have female external genitalia, spontaneous development of normal pubic hair and breasts at puberty, and normal to late menarche followed by oligoamenorrhea and infertility. Pelvic ultrasound shows a small or normal uterus and normal or enlarged ovaries with cysts. However, women with LHB mutations can be treated with luteinizing hormone or chorionic gonadotropin (CG; 118860) replacement therapy; women with LH receptor mutations are resistant to LH, and no treatment is effective in recovering their fertility.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82881">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_370197"><div><strong>Deafness-infertility syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>370197</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1970187</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">STRC-related autosomal recessive hearing loss (STRC-HL) comprises both nonsyndromic sensorineural hearing loss and sensorineural hearing loss with decreased fertility in males who have biallelic contiguous gene deletions involving STRC and CATSPER2. The hearing loss is mild to moderate, congenital, bilateral, and symmetric. Mean pure tone hearing loss averages 40-50 decibels (dB) at the time of diagnosis; hearing loss is not severe to profound in children or young adults. Of note, while many newborns with STRC-HL will be identified by newborn hearing screening (NBHS), some newborns with STRC-HL will not because some screening methods may not detect milder hearing loss. Males with biallelic contiguous gene deletions involving STRC and CATSPER2 are at risk for CATSPER2-related male infertility due to morphologic sperm abnormalities that affect sperm motility. In contrast, females with contiguous gene deletions do not have related fertility issues.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/370197">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_439" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ataxia-telangiectasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_370197" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Deafness-infertility syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82881" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Isolated lutropin deficiency</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/16524365">Intracytoplasmic sperm injection by testicular sperm in patients with aspermia or azoospermia after cancer treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zorn B,
|
||
Virant-Klun I,
|
||
Stanovnik M,
|
||
Drobnic S,
|
||
Meden-Vrtovec H</span><br />
|
||
<span class="medgenPMjournal">Int J Androl</span>
|
||
2006 Oct;29(5):521-7.
|
||
Epub 2006 Mar 8
|
||
doi: 10.1111/j.1365-2605.2006.00684.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16524365" target="_blank">16524365</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22abnormal%20spermatogenesis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37890247">Gut microbiota combined with metabolome dissects long-term nanoplastics exposure-induced disturbed spermatogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhou Y,
|
||
Zhong X,
|
||
Chen L,
|
||
Gong L,
|
||
Luo L,
|
||
He Q,
|
||
Zhu L,
|
||
Tian K</span><br />
|
||
<span class="medgenPMjournal">Ecotoxicol Environ Saf</span>
|
||
2023 Nov 15;267:115626.
|
||
Epub 2023 Oct 25
|
||
doi: 10.1016/j.ecoenv.2023.115626.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37890247" target="_blank">37890247</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26166607">Impact of Metformin on Male Reproduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferreira C,
|
||
Sousa M,
|
||
Rabaça A,
|
||
Oliveira PF,
|
||
Alves MG,
|
||
Sá R</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2015;21(25):3621-33.
|
||
doi: 10.2174/1381612821666150710150041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26166607" target="_blank">26166607</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22289286">Epigenetics of the male gamete.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Carrell DT</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
2012 Feb;97(2):267-74.
|
||
doi: 10.1016/j.fertnstert.2011.12.036.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22289286" target="_blank">22289286</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19143729">Programmed cell death in varicocele-bearing testes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hassan A,
|
||
el-Nashar EM,
|
||
Mostafa T</span><br />
|
||
<span class="medgenPMjournal">Andrologia</span>
|
||
2009 Feb;41(1):39-45.
|
||
doi: 10.1111/j.1439-0272.2008.00894.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19143729" target="_blank">19143729</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18413059">Gene polymorphisms/mutations relevant to abnormal spermatogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nuti F,
|
||
Krausz C</span><br />
|
||
<span class="medgenPMjournal">Reprod Biomed Online</span>
|
||
2008 Apr;16(4):504-13.
|
||
doi: 10.1016/s1472-6483(10)60457-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18413059" target="_blank">18413059</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20spermatogenesis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32319429">Progress in Research on Sperm DNA Fragmentation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Qiu Y,
|
||
Yang H,
|
||
Li C,
|
||
Xu C</span><br />
|
||
<span class="medgenPMjournal">Med Sci Monit</span>
|
||
2020 Apr 22;26:e918746.
|
||
doi: 10.12659/MSM.918746.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32319429" target="_blank">32319429</a><a href="/pmc/articles/PMC7191954" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26568496">Adolescent Varicoceles and Infertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Casey JT,
|
||
Misseri R</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
|
||
2015 Dec;44(4):835-42.
|
||
Epub 2015 Aug 24
|
||
doi: 10.1016/j.ecl.2015.07.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26568496" target="_blank">26568496</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26166607">Impact of Metformin on Male Reproduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferreira C,
|
||
Sousa M,
|
||
Rabaça A,
|
||
Oliveira PF,
|
||
Alves MG,
|
||
Sá R</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2015;21(25):3621-33.
|
||
doi: 10.2174/1381612821666150710150041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26166607" target="_blank">26166607</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18413059">Gene polymorphisms/mutations relevant to abnormal spermatogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nuti F,
|
||
Krausz C</span><br />
|
||
<span class="medgenPMjournal">Reprod Biomed Online</span>
|
||
2008 Apr;16(4):504-13.
|
||
doi: 10.1016/s1472-6483(10)60457-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18413059" target="_blank">18413059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2899562">Infertility in a patient with abnormal spermatogenesis and in utero DES exposure.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hembree WC,
|
||
Nagler HM,
|
||
Fang JS,
|
||
Myles EL,
|
||
Jagiello GM</span><br />
|
||
<span class="medgenPMjournal">Int J Fertil</span>
|
||
1988 May-Jun;33(3):173-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2899562" target="_blank">2899562</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20spermatogenesis%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (25)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35662548">Impact of cannabinoids on pregnancy, reproductive health, and offspring outcomes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lo JO,
|
||
Hedges JC,
|
||
Girardi G</span><br />
|
||
<span class="medgenPMjournal">Am J Obstet Gynecol</span>
|
||
2022 Oct;227(4):571-581.
|
||
Epub 2022 May 31
|
||
doi: 10.1016/j.ajog.2022.05.056.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35662548" target="_blank">35662548</a><a href="/pmc/articles/PMC9530020" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26166607">Impact of Metformin on Male Reproduction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ferreira C,
|
||
Sousa M,
|
||
Rabaça A,
|
||
Oliveira PF,
|
||
Alves MG,
|
||
Sá R</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2015;21(25):3621-33.
|
||
doi: 10.2174/1381612821666150710150041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26166607" target="_blank">26166607</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25200553">Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kuo TM,
|
||
Luo SY,
|
||
Chiang SL,
|
||
Lee CP,
|
||
Liu YF,
|
||
Chang JG,
|
||
Tsai MH,
|
||
Ko YC</span><br />
|
||
<span class="medgenPMjournal">J Biomed Sci</span>
|
||
2014 Sep 9;21(1):93.
|
||
doi: 10.1186/s12929-014-0093-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25200553" target="_blank">25200553</a><a href="/pmc/articles/PMC4256803" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24100262">Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li X,
|
||
Mao Z,
|
||
Wu M,
|
||
Xia J</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2013 Oct 8;3:2842.
|
||
doi: 10.1038/srep02842.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24100262" target="_blank">24100262</a><a href="/pmc/articles/PMC3792414" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18696233">Positioning of chromosome 15, 18, X and Y centromeres in sperm cells of fertile individuals and infertile patients with increased level of aneuploidy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Olszewska M,
|
||
Wiland E,
|
||
Kurpisz M</span><br />
|
||
<span class="medgenPMjournal">Chromosome Res</span>
|
||
2008;16(6):875-90.
|
||
Epub 2008 Aug 15
|
||
doi: 10.1007/s10577-008-1246-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18696233" target="_blank">18696233</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20spermatogenesis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36656346">circRNA-miRNA-mRNA network analysis to explore the pathogenesis of abnormal spermatogenesis due to aberrant m6A methylation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhong D,
|
||
Zhang L,
|
||
Huang K,
|
||
Chen M,
|
||
Chen Y,
|
||
Liu Q,
|
||
Shi D,
|
||
Li H</span><br />
|
||
<span class="medgenPMjournal">Cell Tissue Res</span>
|
||
2023 May;392(2):605-620.
|
||
Epub 2023 Jan 19
|
||
doi: 10.1007/s00441-022-03725-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36656346" target="_blank">36656346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30744807">XRCC1 deficiency correlates with increased DNA damage and male infertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh V,
|
||
Kumar Mohanty S,
|
||
Verma P,
|
||
Chakraborty A,
|
||
Trivedi S,
|
||
Rajender S,
|
||
Singh K</span><br />
|
||
<span class="medgenPMjournal">Mutat Res Genet Toxicol Environ Mutagen</span>
|
||
2019 Mar;839:1-8.
|
||
Epub 2019 Jan 15
|
||
doi: 10.1016/j.mrgentox.2019.01.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30744807" target="_blank">30744807</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26032139">Histology of Testicular Biopsies Obtained for Experimental Fertility Preservation Protocol in Boys with Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pietzak EJ 3rd,
|
||
Tasian GE,
|
||
Tasian SK,
|
||
Brinster RL,
|
||
Carlson C,
|
||
Ginsberg JP,
|
||
Kolon TF</span><br />
|
||
<span class="medgenPMjournal">J Urol</span>
|
||
2015 Nov;194(5):1420-4.
|
||
Epub 2015 May 30
|
||
doi: 10.1016/j.juro.2015.04.117.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26032139" target="_blank">26032139</a><a href="/pmc/articles/PMC4615387" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24852814">Real-time scrotal ultrasound of patients with varicoceles: correlation with impaired semen analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Babaei Jandaghi A,
|
||
Moradi H,
|
||
Hamidi Madani A,
|
||
Nasseh H,
|
||
Keshavarz Zirak A,
|
||
Pourghorban R</span><br />
|
||
<span class="medgenPMjournal">Eur Radiol</span>
|
||
2014 Sep;24(9):2245-51.
|
||
Epub 2014 May 24
|
||
doi: 10.1007/s00330-014-3218-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24852814" target="_blank">24852814</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22177092">Redefining abnormal follicle-stimulating hormone in the male infertility population.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gordetsky J,
|
||
van Wijngaarden E,
|
||
O'Brien J</span><br />
|
||
<span class="medgenPMjournal">BJU Int</span>
|
||
2012 Aug;110(4):568-72.
|
||
Epub 2011 Dec 16
|
||
doi: 10.1111/j.1464-410X.2011.10783.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22177092" target="_blank">22177092</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20spermatogenesis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39062554">Elucidating the Transcriptional States of Spermatogenesis-Joint Analysis of Germline and Supporting Cell, Mice and Human, Normal and Perturbed, Bulk and Single-Cell RNA-Seq.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AbuMadighem A,
|
||
Cohen O,
|
||
Huleihel M</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2024 Jul 12;14(7)
|
||
doi: 10.3390/biom14070840.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39062554" target="_blank">39062554</a><a href="/pmc/articles/PMC11274546" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36240522">Flurochloridone induced abnormal spermatogenesis by damaging testicular Sertoli cells in mice.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sun W,
|
||
Tian F,
|
||
Pan H,
|
||
Chang X,
|
||
Xia M,
|
||
Hu J,
|
||
Wang Y,
|
||
Li R,
|
||
Li W,
|
||
Yang M,
|
||
Zhou Z</span><br />
|
||
<span class="medgenPMjournal">Ecotoxicol Environ Saf</span>
|
||
2022 Nov;246:114163.
|
||
Epub 2022 Oct 11
|
||
doi: 10.1016/j.ecoenv.2022.114163.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36240522" target="_blank">36240522</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28991497">Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ghasemi H,
|
||
Khodadadi I,
|
||
Fattahi A,
|
||
Moghimbeigi A,
|
||
Tavilani H</span><br />
|
||
<span class="medgenPMjournal">Syst Biol Reprod Med</span>
|
||
2017 Dec;63(6):382-390.
|
||
Epub 2017 Oct 9
|
||
doi: 10.1080/19396368.2017.1374488.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28991497" target="_blank">28991497</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19443909">Considerations in evaluating human spermatogenesis on the basis of total sperm per ejaculate.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Amann RP</span><br />
|
||
<span class="medgenPMjournal">J Androl</span>
|
||
2009 Nov-Dec;30(6):626-41.
|
||
Epub 2009 May 14
|
||
doi: 10.2164/jandrol.108.006817.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19443909" target="_blank">19443909</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19143729">Programmed cell death in varicocele-bearing testes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hassan A,
|
||
el-Nashar EM,
|
||
Mostafa T</span><br />
|
||
<span class="medgenPMjournal">Andrologia</span>
|
||
2009 Feb;41(1):39-45.
|
||
doi: 10.1111/j.1439-0272.2008.00894.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19143729" target="_blank">19143729</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Abnormal%20spermatogenesis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (27)</a></div></div>
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