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<!--
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UID=474435
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ConceptID=C3272802
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Hamartomatous polyposis</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>474435</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3272802</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Gastrointestinal hamartoma</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004390">HP:0004390</a></td></tr>
|
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<tr><td>Monarch Initiative:</td>
|
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<td><a href="https://monarchinitiative.org/disease/MONDO:0006231" target="_blank">MONDO:0006231</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">Polyp-like protrusions which are histologically hamartomas. These can occur throughout the gastrointestinal tract. Hamartomatous polyps are composed of the normal cellular elements of the gastrointestinal tract, but have a markedly distorted architecture. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Hamartomatous polyposis</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/152871" ref="tree=MeSH" title="MedGen record for Gastrointestinal Polyp">Gastrointestinal Polyp</a></span><ul><li><span class="matched_ds">Hamartomatous polyposis</span><ul><li><span class="TLline"><a href="/medgen/474434" ref="tree=MeSH" title="MedGen record for Colorectal hamartoma">Colorectal hamartoma</a></span><ul><li><span class="TLline"><a href="/medgen/474436" ref="tree=MeSH" title="MedGen record for Colorectal Cowden-Associated Polyp">Colorectal Cowden-Associated Polyp</a></span></li><li><span class="TLline"><a href="/medgen/235116" ref="tree=MeSH" title="MedGen record for Colorectal juvenile polyp">Colorectal juvenile polyp</a></span><ul><li><span class="TLline"><a href="/medgen/234160" ref="tree=MeSH" title="MedGen record for Colon juvenile polyp">Colon juvenile polyp</a></span></li><li><span class="TLline"><a href="/medgen/235531" ref="tree=MeSH" title="MedGen record for Rectal Juvenile Polyp">Rectal Juvenile Polyp</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/473967" ref="tree=MeSH" title="MedGen record for Colorectal Peutz-Jeghers Polyp">Colorectal Peutz-Jeghers Polyp</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/90961" ref="tree=MeSH" title="MedGen record for Gastric hamartomatous polyp">Gastric hamartomatous polyp</a></span><ul><li><span class="TLline"><a href="/medgen/272662" ref="tree=MeSH" title="MedGen record for Gastric Cronkhite Canada Polyposis">Gastric Cronkhite Canada Polyposis</a></span></li><li><span class="TLline"><a href="/medgen/234298" ref="tree=MeSH" title="MedGen record for Gastric Juvenile Polyp">Gastric Juvenile Polyp</a></span></li><li><span class="TLline"><a href="/medgen/233323" ref="tree=MeSH" title="MedGen record for Peutz-Jeghers polyp of the stomach">Peutz-Jeghers polyp of the stomach</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/1813073" ref="tree=MeSH" title="MedGen record for Juvenile gastrointestinal polyposis">Juvenile gastrointestinal polyposis</a></span></li><li><span class="TLline"><a href="/medgen/113158" ref="tree=MeSH" title="MedGen record for Juvenile polyps">Juvenile polyps</a></span><ul><li><span class="TLline"><a href="/medgen/474152" ref="tree=MeSH" title="MedGen record for Juvenile Polyp of the Small Intestine">Juvenile Polyp of the Small Intestine</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/141582" ref="tree=MeSH" title="MedGen record for Peutz-Jeghers polyp">Peutz-Jeghers polyp</a></span><ul><li><span class="TLline"><a href="/medgen/78552" ref="tree=MeSH" title="MedGen record for Peutz-Jeghers Polyp of the Small Intestine">Peutz-Jeghers Polyp of the Small Intestine</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/224907" ref="tree=MeSH" title="MedGen record for Small intestinal polyp">Small intestinal polyp</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
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<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_18404"><div><strong>Peutz-Jeghers syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18404</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0031269</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Peutz-Jeghers syndrome (PJS) is characterized by the association of gastrointestinal (GI) polyposis, mucocutaneous pigmentation, and cancer predisposition. PJS-type hamartomatous polyps are most common in the small intestine (in order of prevalence: jejunum, ileum, and duodenum) but can also occur in the stomach, large bowel, and extraintestinal sites including the renal pelvis, bronchus, gall bladder, nasal passages, urinary bladder, and ureters. GI polyps can result in chronic bleeding, anemia, and recurrent obstruction and intussusception requiring repeated laparotomy and bowel resection. Mucocutaneous hyperpigmentation presents in childhood as dark blue to dark brown macules around the mouth, eyes, and nostrils, in the perianal area, and on the buccal mucosa. Hyperpigmented macules on the fingers are common. The macules may fade in puberty and adulthood. Recognition of the distinctive skin manifestations is important especially in individuals who have PJS as the result of a de novo pathogenic variant as these skin findings often predate GI signs and symptoms. Individuals with PJS are at increased risk for a wide variety of epithelial malignancies (colorectal, gastric, pancreatic, breast, and ovarian cancers). Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. Males occasionally develop large calcifying Sertoli cell tumors of the testes, which secrete estrogen and can lead to gynecomastia, advanced skeletal age, and ultimately short stature, if untreated.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18404">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_129128"><div><strong>Cronkhite-Canada syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>129128</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0282207</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Cronkhite-Canada syndrome is characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, skin hyperpigmentation, and diarrhea. It is associated with high morbidity (summary by Sweetser et al., 2012).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/129128">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331400"><div><strong>Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331400</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1832942</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Hereditary hemorrhagic telangiectasia (HHT) is characterized by the presence of multiple arteriovenous malformations (AVMs) that lack intervening capillaries and result in direct connections between arteries and veins. The most common clinical manifestation is spontaneous and recurrent nosebleeds (epistaxis) beginning on average at age 12 years. Telangiectases (small AVMs) are characteristically found on the lips, tongue, buccal and gastrointestinal (GI) mucosa, face, and fingers. The appearance of telangiectases is generally later than epistaxis but may be during childhood. Large AVMs occur most often in the lungs, liver, or brain; complications from bleeding or shunting may be sudden and catastrophic. A minority of individuals with HHT have GI bleeding, which is rarely seen before age 50 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331400">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_331813"><div><strong>Cerebelloparenchymal Disorder VI</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>331813</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1834711</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/331813">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767432"><div><strong>Cowden syndrome 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767432</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554518</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">PIK3CA-related overgrowth spectrum (PROS) encompasses a range of clinical findings in which the core features are congenital or early-childhood onset of segmental/focal overgrowth with or without cellular dysplasia. Prior to the identification of PIK3CA as the causative gene, PROS was separated into distinct clinical syndromes based on the tissues and/or organs involved (e.g., MCAP [megalencephaly-capillary malformation] syndrome and CLOVES [congenital lipomatous asymmetric overgrowth of the trunk, lymphatic, capillary, venous, and combined-type vascular malformations, epidermal nevi, skeletal and spinal anomalies] syndrome). The predominant areas of overgrowth include the brain, limbs (including fingers and toes), trunk (including abdomen and chest), and face, all usually in an asymmetric distribution. Generalized brain overgrowth may be accompanied by secondary overgrowth of specific brain structures resulting in ventriculomegaly, a markedly thick corpus callosum, and cerebellar tonsillar ectopia with crowding of the posterior fossa. Vascular malformations may include capillary, venous, and less frequently, arterial or mixed (capillary-lymphatic-venous or arteriovenous) malformations. Lymphatic malformations may be in various locations (internal and/or external) and can cause various clinical issues, including swelling, pain, and occasionally localized bleeding secondary to trauma. Lipomatous overgrowth may occur ipsilateral or contralateral to a vascular malformation, if present. The degree of intellectual disability appears to be mostly related to the presence and severity of seizures, cortical dysplasia (e.g., polymicrogyria), and hydrocephalus. Many children have feeding difficulties that are often multifactorial in nature. Endocrine issues affect a small number of individuals and most commonly include hypoglycemia (largely hypoinsulinemic hypoketotic hypoglycemia), hypothyroidism, and growth hormone deficiency.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767432">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767433"><div><strong>Cowden syndrome 6</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767433</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554519</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">\n\nThe features of Cowden syndrome overlap with those of another disorder called Bannayan-Riley-Ruvalcaba syndrome. People with Bannayan-Riley-Ruvalcaba syndrome also develop hamartomas and other noncancerous tumors. Some people with Cowden syndrome have relatives diagnosed with Bannayan-Riley-Ruvalcaba syndrome, and other affected individuals have the characteristic features of both conditions. Based on these similarities, researchers have proposed that Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome represent a spectrum of overlapping features known as PTEN hamartoma tumor syndrome (named for the genetic cause of the conditions) instead of two distinct conditions.\n\nSome people do not meet the strict criteria for a clinical diagnosis of Cowden syndrome, but they have some of the characteristic features of the condition, particularly the cancers. These individuals are often described as having Cowden-like syndrome. Both Cowden syndrome and Cowden-like syndrome are caused by mutations in the same genes.\n\nCowden syndrome is associated with an increased risk of developing several types of cancer, particularly cancers of the breast, a gland in the lower neck called the thyroid, and the lining of the uterus (the endometrium). Other cancers that have been identified in people with Cowden syndrome include kidney cancer, colorectal cancer, and an agressive form of skin cancer called melanoma. Compared with the general population, people with Cowden syndrome develop these cancers at younger ages, often beginning in their thirties or forties. People with Cowden syndrome are also more likely to develop more than one cancer during their lifetimes compared to the general population. Other diseases of the breast, thyroid, and endometrium are also common in Cowden syndrome. Additional signs and symptoms can include an enlarged head (macrocephaly) and a rare, noncancerous brain tumor called Lhermitte-Duclos disease. A small percentage of affected individuals have delayed development, intellectual disability, or autism spectrum disorder, which can affect communication and social interaction.\n\nAlmost everyone with Cowden syndrome develops hamartomas. These growths are most commonly found on the skin and mucous membranes (such as the lining of the mouth and nose), but they can also occur in the intestine and other parts of the body. The growth of hamartomas on the skin and mucous membranes typically becomes apparent by a person's late twenties.\n\nCowden syndrome is a genetic disorder characterized by multiple noncancerous, tumor-like growths called hamartomas and an increased risk of developing certain cancers.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767433">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331813" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebelloparenchymal Disorder VI</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767432" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767433" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cowden syndrome 6</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_129128" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cronkhite-Canada syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_331400" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_18404" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Peutz-Jeghers syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37054692">Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto H,
|
||
Sakamoto H,
|
||
Kumagai H,
|
||
Abe T,
|
||
Ishiguro S,
|
||
Uchida K,
|
||
Kawasaki Y,
|
||
Saida Y,
|
||
Sano Y,
|
||
Takeuchi Y,
|
||
Tajika M,
|
||
Nakajima T,
|
||
Banno K,
|
||
Funasaka Y,
|
||
Hori S,
|
||
Yamaguchi T,
|
||
Yoshida T,
|
||
Ishikawa H,
|
||
Iwama T,
|
||
Okazaki Y,
|
||
Saito Y,
|
||
Matsuura N,
|
||
Mutoh M,
|
||
Tomita N,
|
||
Akiyama T,
|
||
Yamamoto T,
|
||
Ishida H,
|
||
Nakayama Y</span><br />
|
||
<span class="medgenPMjournal">Digestion</span>
|
||
2023;104(5):335-347.
|
||
Epub 2023 Apr 13
|
||
doi: 10.1159/000529799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37054692" target="_blank">37054692</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36925460">Hamartomatous polyps: Diagnosis, surveillance, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gorji L,
|
||
Albrecht P</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2023 Feb 28;29(8):1304-1314.
|
||
doi: 10.3748/wjg.v29.i8.1304.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36925460" target="_blank">36925460</a><a href="/pmc/articles/PMC10011967" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28786406">Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kanth P,
|
||
Grimmett J,
|
||
Champine M,
|
||
Burt R,
|
||
Samadder NJ</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2017 Oct;112(10):1509-1525.
|
||
Epub 2017 Aug 8
|
||
doi: 10.1038/ajg.2017.212.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28786406" target="_blank">28786406</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hamartomatous%20polyposis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (17)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37054692">Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto H,
|
||
Sakamoto H,
|
||
Kumagai H,
|
||
Abe T,
|
||
Ishiguro S,
|
||
Uchida K,
|
||
Kawasaki Y,
|
||
Saida Y,
|
||
Sano Y,
|
||
Takeuchi Y,
|
||
Tajika M,
|
||
Nakajima T,
|
||
Banno K,
|
||
Funasaka Y,
|
||
Hori S,
|
||
Yamaguchi T,
|
||
Yoshida T,
|
||
Ishikawa H,
|
||
Iwama T,
|
||
Okazaki Y,
|
||
Saito Y,
|
||
Matsuura N,
|
||
Mutoh M,
|
||
Tomita N,
|
||
Akiyama T,
|
||
Yamamoto T,
|
||
Ishida H,
|
||
Nakayama Y</span><br />
|
||
<span class="medgenPMjournal">Digestion</span>
|
||
2023;104(5):335-347.
|
||
Epub 2023 Apr 13
|
||
doi: 10.1159/000529799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37054692" target="_blank">37054692</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36925460">Hamartomatous polyps: Diagnosis, surveillance, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gorji L,
|
||
Albrecht P</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2023 Feb 28;29(8):1304-1314.
|
||
doi: 10.3748/wjg.v29.i8.1304.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36925460" target="_blank">36925460</a><a href="/pmc/articles/PMC10011967" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20420945">Hereditary and familial colon cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jasperson KW,
|
||
Tuohy TM,
|
||
Neklason DW,
|
||
Burt RW</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2010 Jun;138(6):2044-58.
|
||
doi: 10.1053/j.gastro.2010.01.054.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20420945" target="_blank">20420945</a><a href="/pmc/articles/PMC3057468" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19414148">Hamartomatous polyposis syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gammon A,
|
||
Jasperson K,
|
||
Kohlmann W,
|
||
Burt RW</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2009;23(2):219-31.
|
||
doi: 10.1016/j.bpg.2009.02.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19414148" target="_blank">19414148</a><a href="/pmc/articles/PMC2678968" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17768394">Hamartomatous polyposis syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zbuk KM,
|
||
Eng C</span><br />
|
||
<span class="medgenPMjournal">Nat Clin Pract Gastroenterol Hepatol</span>
|
||
2007 Sep;4(9):492-502.
|
||
doi: 10.1038/ncpgasthep0902.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17768394" target="_blank">17768394</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamartomatous%20polyposis%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (102)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37054692">Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yamamoto H,
|
||
Sakamoto H,
|
||
Kumagai H,
|
||
Abe T,
|
||
Ishiguro S,
|
||
Uchida K,
|
||
Kawasaki Y,
|
||
Saida Y,
|
||
Sano Y,
|
||
Takeuchi Y,
|
||
Tajika M,
|
||
Nakajima T,
|
||
Banno K,
|
||
Funasaka Y,
|
||
Hori S,
|
||
Yamaguchi T,
|
||
Yoshida T,
|
||
Ishikawa H,
|
||
Iwama T,
|
||
Okazaki Y,
|
||
Saito Y,
|
||
Matsuura N,
|
||
Mutoh M,
|
||
Tomita N,
|
||
Akiyama T,
|
||
Yamamoto T,
|
||
Ishida H,
|
||
Nakayama Y</span><br />
|
||
<span class="medgenPMjournal">Digestion</span>
|
||
2023;104(5):335-347.
|
||
Epub 2023 Apr 13
|
||
doi: 10.1159/000529799.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37054692" target="_blank">37054692</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27241107">Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Meserve EE,
|
||
Nucci MR</span><br />
|
||
<span class="medgenPMjournal">Surg Pathol Clin</span>
|
||
2016 Jun;9(2):243-68.
|
||
doi: 10.1016/j.path.2016.01.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27241107" target="_blank">27241107</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20420945">Hereditary and familial colon cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jasperson KW,
|
||
Tuohy TM,
|
||
Neklason DW,
|
||
Burt RW</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2010 Jun;138(6):2044-58.
|
||
doi: 10.1053/j.gastro.2010.01.054.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20420945" target="_blank">20420945</a><a href="/pmc/articles/PMC3057468" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19414148">Hamartomatous polyposis syndromes.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Gammon A,
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<div class="nl"><a target="_blank" href="/pubmed/17768394">Hamartomatous polyposis syndromes.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36082652">Sirolimus treatment of a PTEN hamartoma tumor syndrome presenting with melena.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/21877933" target="_blank">21877933</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Burt RW,
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||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamartomatous%20polyposis%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/36925460">Hamartomatous polyps: Diagnosis, surveillance, and management.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gorji L,
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||
<div class="nl"><a target="_blank" href="/pubmed/22157284">Inherited colorectal cancer syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kastrinos F,
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<span class="bold">PMID: </span><a href="/pubmed/22157284" target="_blank">22157284</a><a href="/pmc/articles/PMC3240819" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/20420945">Hereditary and familial colon cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jasperson KW,
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Tuohy TM,
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Neklason DW,
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Burt RW</span><br />
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<span class="medgenPMjournal">Gastroenterology</span>
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<span class="bold">PMID: </span><a href="/pubmed/20420945" target="_blank">20420945</a><a href="/pmc/articles/PMC3057468" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/19414148">Hamartomatous polyposis syndromes.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Gammon A,
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Jasperson K,
|
||
Kohlmann W,
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Burt RW</span><br />
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<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
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2009;23(2):219-31.
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doi: 10.1016/j.bpg.2009.02.007.
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<span class="bold">PMID: </span><a href="/pubmed/19414148" target="_blank">19414148</a><a href="/pmc/articles/PMC2678968" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/18672141">Hamartomatous polyposis syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Calva D,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamartomatous%20polyposis%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (36)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/31107726">Clinical and Histologic Overlap and Distinction Among Various Hamartomatous Polyposis Syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gilad O,
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Rosner G,
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Fliss-Isakov N,
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Aharon-Kaspi S,
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Strul H,
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Gluck N,
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<span class="bold">PMID: </span><a href="/pubmed/31107726" target="_blank">31107726</a><a href="/pmc/articles/PMC6602765" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22157284">Inherited colorectal cancer syndromes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Kastrinos F,
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||
Syngal S</span><br />
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<span class="medgenPMjournal">Cancer J</span>
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2011 Nov-Dec;17(6):405-15.
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doi: 10.1097/PPO.0b013e318237e408.
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<span class="bold">PMID: </span><a href="/pubmed/22157284" target="_blank">22157284</a><a href="/pmc/articles/PMC3240819" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20420945">Hereditary and familial colon cancer.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Jasperson KW,
|
||
Tuohy TM,
|
||
Neklason DW,
|
||
Burt RW</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
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||
2010 Jun;138(6):2044-58.
|
||
doi: 10.1053/j.gastro.2010.01.054.
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<span class="bold">PMID: </span><a href="/pubmed/20420945" target="_blank">20420945</a><a href="/pmc/articles/PMC3057468" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19414148">Hamartomatous polyposis syndromes.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Gammon A,
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Jasperson K,
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||
Kohlmann W,
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||
Burt RW</span><br />
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<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
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2009;23(2):219-31.
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||
doi: 10.1016/j.bpg.2009.02.007.
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<span class="bold">PMID: </span><a href="/pubmed/19414148" target="_blank">19414148</a><a href="/pmc/articles/PMC2678968" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/10408777">Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Westerman AM,
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Entius MM,
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Boor PP,
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Koole R,
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de Baar E,
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Offerhaus GJ,
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Lubinski J,
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Halley DJ,
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<span class="bold">PMID: </span><a href="/pubmed/10408777" target="_blank">10408777</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamartomatous%20polyposis%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (39)</a></div></div>
|
||
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|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36265529">Occurrence of gastric cancer in patients with juvenile polyposis syndrome: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh AD,
|
||
Gupta A,
|
||
Mehta N,
|
||
Heald B,
|
||
Macaron C,
|
||
Liska D,
|
||
Bhatt A,
|
||
Burke CA</span><br />
|
||
<span class="medgenPMjournal">Gastrointest Endosc</span>
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||
2023 Mar;97(3):407-414.e1.
|
||
Epub 2022 Oct 18
|
||
doi: 10.1016/j.gie.2022.10.026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36265529" target="_blank">36265529</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamartomatous%20polyposis%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
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|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22hamartomatous%20polyposis%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Hamartomatous%20polyposis%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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