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<!--
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UID=472980
|
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ConceptID=C0240997
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Decreased circulating ceruloplasmin concentration</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>472980</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0240997</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Decreased serum ceruloplasmin</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0010837">HP:0010837</a></td></tr>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Decreased concentration of ceruloplasmin in the blood. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Decreased circulating ceruloplasmin concentration</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/867398" ref="tree=MeSH" title="MedGen record for Abnormality of metabolism/homeostasis">Abnormality of metabolism/homeostasis</a></span><ul><li><span class="TLline"><a href="/medgen/1701080" ref="tree=MeSH" title="MedGen record for Abnormal circulating metabolite concentration">Abnormal circulating metabolite concentration</a></span><ul><li><span class="TLline"><a href="/medgen/892289" ref="tree=MeSH" title="MedGen record for Abnormal circulating protein concentration">Abnormal circulating protein concentration</a></span><ul><li><span class="TLline"><a href="/medgen/1726009" ref="tree=MeSH" title="MedGen record for Abnormal circulating ceruloplasmin concentration">Abnormal circulating ceruloplasmin concentration</a></span><ul><li><span class="matched_ds">Decreased circulating ceruloplasmin concentration</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_42426"><div><strong>Wilson disease</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>42426</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0019202</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Wilson disease is a disorder of copper metabolism that, when untreated, can present with hepatic, neurologic, or psychiatric disturbances – or a combination of these – in individuals ages three years to older than 70 years. Manifestations in untreated individuals vary among and within families. Liver disease can include recurrent jaundice, simple acute self-limited hepatitis-like illness, autoimmune-type hepatitis, fulminant hepatic failure, or chronic liver disease. Neurologic presentations can include dysarthria, movement disorders (tremors, involuntary movements, chorea, choreoathetosis), dystonia (mask-like facies, rigidity, gait disturbance, pseudobulbar involvement), dysautonomia, seizures, sleep disorders, or insomnia. Psychiatric disturbances can include depression, bipolar disorder / bipolar spectrum disorder, neurotic behaviors, personality changes, or psychosis. Other multisystem involvement can include the eye (Kayser-Fleischer rings), hemolytic anemia, the kidneys, the endocrine glands, and the heart.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/42426">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_44030"><div><strong>Menkes kinky-hair syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44030</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022716</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Menkes disease (MNK) is an X-linked recessive disorder characterized by generalized copper deficiency. The clinical features result from the dysfunction of several copper-dependent enzymes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/44030">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_82793"><div><strong>Cutis laxa, X-linked</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82793</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0268353</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Occipital horn syndrome (OHS) is a rare connective tissue disorder characterized by hyperelastic and bruisable skin, hernias, bladder diverticula, hyperextensible joints, varicosities, and multiple skeletal abnormalities. The disorder is sometimes accompanied by mild neurologic impairment, and bony abnormalities of the occiput are a common feature, giving rise to the name (summary by Das et al., 1995).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82793">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_224809"><div><strong>Autosomal recessive keratitis-ichthyosis-deafness syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>224809</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1275089</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">IDEDNIK syndrome is characterized by enteropathy, poor weight gain, growth deficiency, skin manifestations (ichthyosis, erythroderma, and keratoderma), sparse hair, global developmental delay, mild-to-severe intellectual disability, and deafness. Additional manifestations can include liver disease, recurrent infections, and hematologic and ocular manifestations (photophobia, corneal scarring, and keratitis). Reduced serum ceruloplasmin and total copper levels are common. Some individuals have findings on brain MRI (cerebral atrophy, basal ganglia abnormalities, and thin corpus callosum). Death prior to age two years occurs in some individuals due to severe enteropathy or sepsis; in others survival into adulthood is reported.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/224809">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_895025"><div><strong>TMEM199-CDG</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>895025</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225190</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital disorder of glycosylation type IIp (CDG2P) is an autosomal recessive metabolic disorder characterized by mild liver dysfunction, which may be found incidentally during adolescence. Laboratory abnormalities include elevated liver enzymes and alkaline phosphatase, coagulation factor deficiencies, hypercholesterolemia, and low ceruloplasmin. Serum isoelectric focusing of proteins shows a combined defect of N- and O-glycosylation, suggestive of a Golgi defect (summary by Jansen et al., 2016). For an overview of congenital disorders of glycosylation, see CDG1A (212065) and CDG2A (212066).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/895025">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_906792"><div><strong>CCDC115-CDG</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>906792</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225191</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Congenital disorder of glycosylation type IIo (CDG2O) is an autosomal recessive metabolic disorder characterized by infantile onset of progressive liver failure, hypotonia, and delayed psychomotor development. Laboratory abnormalities include elevated liver enzymes, coagulation factor deficiencies, hypercholesterolemia, and low ceruloplasmin. Serum isoelectric focusing of proteins shows a combined defect of N- and O-glycosylation, suggestive of a Golgi defect (summary by Jansen et al., 2016). For a general discussion of CDGs, see CDG1A (212065).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/906792">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1390458"><div><strong>Congenital disorder of glycosylation, type IIq</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1390458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4479353</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare congenital disorder of glycosylation caused by mutations in the COG2 gene and with characteristics of normal presentation at birth, followed by progressive deterioration with postnatal microcephaly, developmental delay, intellectual disability, seizures, spastic quadriplegia, liver dysfunction, hypocupremia and hypoceruloplasminemia in the first year of life. Diffuse cerebral atrophy and thin corpus callosum may be observed on brain MRI.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1390458">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1659966"><div><strong>Huppke-Brendel syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1659966</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4751114</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Huppke-Brendel syndrome (HBS) is characterized by bilateral congenital cataracts, sensorineural hearing loss, and severe developmental delay. To date, six individuals with HBS have been reported in the literature. All presented in infancy with axial hypotonia; motor delay was apparent in the first few months of life with lack of head control and paucity of limb movement. Seizures have been reported infrequently. In all individuals described to date serum copper and ceruloplasmin levels were very low or undetectable. Brain MRI examination showed hypomyelination, cerebellar hypoplasia mainly affecting the vermis, and wide subarachnoid spaces. None of the individuals reported to date were able to sit or walk independently. All affected individuals died between age ten months and six years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1659966">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_224809" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal recessive keratitis-ichthyosis-deafness syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_906792" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CCDC115-CDG</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1390458" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congenital disorder of glycosylation, type IIq</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_82793" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cutis laxa, X-linked</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1659966" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Huppke-Brendel syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_44030" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Menkes kinky-hair syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_895025" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">TMEM199-CDG</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_42426" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wilson disease</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/10869897">Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McMillan DC,
|
||
Sattar N,
|
||
Talwar D,
|
||
O'Reilly DS,
|
||
McArdle CS</span><br />
|
||
<span class="medgenPMjournal">Nutrition</span>
|
||
2000 Jun;16(6):425-8.
|
||
doi: 10.1016/s0899-9007(00)00270-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10869897" target="_blank">10869897</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10821440">CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuerenburg HJ</span><br />
|
||
<span class="medgenPMjournal">J Neural Transm (Vienna)</span>
|
||
2000;107(3):321-9.
|
||
doi: 10.1007/s007020050026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10821440" target="_blank">10821440</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(decreased%20circulating%20ceruloplasmin%20concentration)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38865064">Effects of Perioperative Zinc Supplementation on Copper Circulating Levels and Expression of Metallothionein and Copper Antioxidant Chaperone-1 in Leukocytes in Patients Undergoing CABG Surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Makiabadi E,
|
||
Nasrollahzadeh J,
|
||
Nakhaeizadeh R,
|
||
Shahparvari MR,
|
||
Roohelhami E</span><br />
|
||
<span class="medgenPMjournal">Biol Trace Elem Res</span>
|
||
2025 Mar;203(3):1297-1304.
|
||
Epub 2024 Jun 12
|
||
doi: 10.1007/s12011-024-04259-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38865064" target="_blank">38865064</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35389755">Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zwart SR,
|
||
Auñón-Chancellor SM,
|
||
Heer M,
|
||
Melin MM,
|
||
Smith SM</span><br />
|
||
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
|
||
2022 May 1;132(5):1232-1239.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1152/japplphysiol.00024.2022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35389755" target="_blank">35389755</a><a href="/pmc/articles/PMC9126217" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29544084">Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Riško P,
|
||
Pláteník J,
|
||
Buchal R,
|
||
Potočková J,
|
||
Kraml PJ</span><br />
|
||
<span class="medgenPMjournal">Atherosclerosis</span>
|
||
2018 May;272:14-20.
|
||
Epub 2018 Mar 3
|
||
doi: 10.1016/j.atherosclerosis.2018.03.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29544084" target="_blank">29544084</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28427851">Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arenas de Larriva AP,
|
||
Norby FL,
|
||
Chen LY,
|
||
Soliman EZ,
|
||
Hoogeveen RC,
|
||
Arking DE,
|
||
Loehr LR,
|
||
Alonso A</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2017 Aug 15;241:223-228.
|
||
Epub 2017 Apr 6
|
||
doi: 10.1016/j.ijcard.2017.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28427851" target="_blank">28427851</a><a href="/pmc/articles/PMC5515669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3917951">Ceruloplasmin and transferrin in human seminal plasma: are they an index of seminiferous tubular function?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Orlando C,
|
||
Caldini AL,
|
||
Barni T,
|
||
Wood WG,
|
||
Strasburger CJ,
|
||
Natali A,
|
||
Maver A,
|
||
Forti G,
|
||
Serio M</span><br />
|
||
<span class="medgenPMjournal">Fertil Steril</span>
|
||
1985 Feb;43(2):290-4.
|
||
doi: 10.1016/s0015-0282(16)48388-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3917951" target="_blank">3917951</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20ceruloplasmin%20concentration%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (11)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28427851">Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arenas de Larriva AP,
|
||
Norby FL,
|
||
Chen LY,
|
||
Soliman EZ,
|
||
Hoogeveen RC,
|
||
Arking DE,
|
||
Loehr LR,
|
||
Alonso A</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2017 Aug 15;241:223-228.
|
||
Epub 2017 Apr 6
|
||
doi: 10.1016/j.ijcard.2017.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28427851" target="_blank">28427851</a><a href="/pmc/articles/PMC5515669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11580917">Assessment of copper status in pregnancy by means of determining the specific oxidase activity of ceruloplasmin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Louro MO,
|
||
Cocho JA,
|
||
Tutor JC</span><br />
|
||
<span class="medgenPMjournal">Clin Chim Acta</span>
|
||
2001 Oct;312(1-2):123-7.
|
||
doi: 10.1016/s0009-8981(01)00607-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11580917" target="_blank">11580917</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3598025">The short and long term effect of gastric partitioning surgery on serum protein levels.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Golner BB,
|
||
Reinhold RB,
|
||
Jacob RA,
|
||
Sadowski JA,
|
||
Russell RM</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Nutr</span>
|
||
1987 Jun;6(3):279-85.
|
||
doi: 10.1080/07315724.1987.10720190.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3598025" target="_blank">3598025</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6282033">Estrogen replacement therapy after the menopause. Estrogenicity and metabolic effects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Helgason S</span><br />
|
||
<span class="medgenPMjournal">Acta Obstet Gynecol Scand Suppl</span>
|
||
1982;107:1-29.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6282033" target="_blank">6282033</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20ceruloplasmin%20concentration%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38865064">Effects of Perioperative Zinc Supplementation on Copper Circulating Levels and Expression of Metallothionein and Copper Antioxidant Chaperone-1 in Leukocytes in Patients Undergoing CABG Surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Makiabadi E,
|
||
Nasrollahzadeh J,
|
||
Nakhaeizadeh R,
|
||
Shahparvari MR,
|
||
Roohelhami E</span><br />
|
||
<span class="medgenPMjournal">Biol Trace Elem Res</span>
|
||
2025 Mar;203(3):1297-1304.
|
||
Epub 2024 Jun 12
|
||
doi: 10.1007/s12011-024-04259-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38865064" target="_blank">38865064</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35389755">Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zwart SR,
|
||
Auñón-Chancellor SM,
|
||
Heer M,
|
||
Melin MM,
|
||
Smith SM</span><br />
|
||
<span class="medgenPMjournal">J Appl Physiol (1985)</span>
|
||
2022 May 1;132(5):1232-1239.
|
||
Epub 2022 Apr 7
|
||
doi: 10.1152/japplphysiol.00024.2022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35389755" target="_blank">35389755</a><a href="/pmc/articles/PMC9126217" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24096552">Copper supplementation at 8 mg neither affects circulating lipids nor liver function in apparently healthy Chilean men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rojas-Sobarzo L,
|
||
Olivares M,
|
||
Brito A,
|
||
Suazo M,
|
||
Araya M,
|
||
Pizarro F</span><br />
|
||
<span class="medgenPMjournal">Biol Trace Elem Res</span>
|
||
2013 Dec;156(1-3):1-4.
|
||
Epub 2013 Oct 6
|
||
doi: 10.1007/s12011-013-9823-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24096552" target="_blank">24096552</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10869897">Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McMillan DC,
|
||
Sattar N,
|
||
Talwar D,
|
||
O'Reilly DS,
|
||
McArdle CS</span><br />
|
||
<span class="medgenPMjournal">Nutrition</span>
|
||
2000 Jun;16(6):425-8.
|
||
doi: 10.1016/s0899-9007(00)00270-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10869897" target="_blank">10869897</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10821440">CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuerenburg HJ</span><br />
|
||
<span class="medgenPMjournal">J Neural Transm (Vienna)</span>
|
||
2000;107(3):321-9.
|
||
doi: 10.1007/s007020050026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10821440" target="_blank">10821440</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20ceruloplasmin%20concentration%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28427851">Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Arenas de Larriva AP,
|
||
Norby FL,
|
||
Chen LY,
|
||
Soliman EZ,
|
||
Hoogeveen RC,
|
||
Arking DE,
|
||
Loehr LR,
|
||
Alonso A</span><br />
|
||
<span class="medgenPMjournal">Int J Cardiol</span>
|
||
2017 Aug 15;241:223-228.
|
||
Epub 2017 Apr 6
|
||
doi: 10.1016/j.ijcard.2017.04.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28427851" target="_blank">28427851</a><a href="/pmc/articles/PMC5515669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10821440">CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuerenburg HJ</span><br />
|
||
<span class="medgenPMjournal">J Neural Transm (Vienna)</span>
|
||
2000;107(3):321-9.
|
||
doi: 10.1007/s007020050026.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10821440" target="_blank">10821440</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20ceruloplasmin%20concentration%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38865064">Effects of Perioperative Zinc Supplementation on Copper Circulating Levels and Expression of Metallothionein and Copper Antioxidant Chaperone-1 in Leukocytes in Patients Undergoing CABG Surgery.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Makiabadi E,
|
||
Nasrollahzadeh J,
|
||
Nakhaeizadeh R,
|
||
Shahparvari MR,
|
||
Roohelhami E</span><br />
|
||
<span class="medgenPMjournal">Biol Trace Elem Res</span>
|
||
2025 Mar;203(3):1297-1304.
|
||
Epub 2024 Jun 12
|
||
doi: 10.1007/s12011-024-04259-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38865064" target="_blank">38865064</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29544084">Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Riško P,
|
||
Pláteník J,
|
||
Buchal R,
|
||
Potočková J,
|
||
Kraml PJ</span><br />
|
||
<span class="medgenPMjournal">Atherosclerosis</span>
|
||
2018 May;272:14-20.
|
||
Epub 2018 Mar 3
|
||
doi: 10.1016/j.atherosclerosis.2018.03.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29544084" target="_blank">29544084</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24096552">Copper supplementation at 8 mg neither affects circulating lipids nor liver function in apparently healthy Chilean men.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rojas-Sobarzo L,
|
||
Olivares M,
|
||
Brito A,
|
||
Suazo M,
|
||
Araya M,
|
||
Pizarro F</span><br />
|
||
<span class="medgenPMjournal">Biol Trace Elem Res</span>
|
||
2013 Dec;156(1-3):1-4.
|
||
Epub 2013 Oct 6
|
||
doi: 10.1007/s12011-013-9823-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24096552" target="_blank">24096552</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8724377">Low ceruloplasmin levels during recovery from major burn injury: influence of open wound size and copper supplementation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cunningham JJ,
|
||
Lydon MK,
|
||
Emerson R,
|
||
Harmatz PR</span><br />
|
||
<span class="medgenPMjournal">Nutrition</span>
|
||
1996 Feb;12(2):83-8.
|
||
doi: 10.1016/0899-9007(96)90704-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8724377" target="_blank">8724377</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3108429">Effects of two low-dose oral contraceptives on circulating components of the coagulation and fibrinolytic systems.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Gevers Leuven JA,
|
||
Kluft C,
|
||
Bertina RM,
|
||
Hessel LW</span><br />
|
||
<span class="medgenPMjournal">J Lab Clin Med</span>
|
||
1987 Jun;109(6):631-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3108429" target="_blank">3108429</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Decreased%20circulating%20ceruloplasmin%20concentration%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
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