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<!--
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UID=465269
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ConceptID=C3178801
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Lacunar stroke</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>465269</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3178801</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Lacunar Stroke; Lacunar Strokes; Lacunar Syndrome; Lacunar Syndromes; Stroke, Lacunar; Strokes, Lacunar; Syndrome, Lacunar; Syndromes, Lacunar</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
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<td>Lacunar stroke (230698000)</td></tr>
|
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<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
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<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0032325">HP:0032325</a></td></tr>
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<div class="portlet_content ln">A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Lacunar stroke</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/19974" ref="tree=MeSH" title="MedGen record for Clinical finding">Clinical finding</a></span><ul><li><span class="TLline"><a href="/medgen/272632" ref="tree=MeSH" title="MedGen record for Finding by Site or System">Finding by Site or System</a></span><ul><li><span class="TLline"><a href="/medgen/96114" ref="tree=MeSH" title="MedGen record for Cardiovascular finding">Cardiovascular finding</a></span><ul><li><span class="TLline"><a href="/medgen/5899" ref="tree=MeSH" title="MedGen record for Ischemic disease">Ischemic disease</a></span><ul><li><span class="TLline"><a href="/medgen/9461" ref="tree=MeSH" title="MedGen record for Infarct">Infarct</a></span><ul><li><span class="TLline"><a href="/medgen/148426" ref="tree=MeSH" title="MedGen record for Brain infarction">Brain infarction</a></span><ul><li><span class="matched_ds">Lacunar stroke</span><ul><li><span class="TLline"><a href="/medgen/1718709" ref="tree=MeSH" title="MedGen record for Pontine ischemic lacunes">Pontine ischemic lacunes</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_324539"><div><strong>Alpha-N-acetylgalactosaminidase deficiency type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>324539</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1836522</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Alpha-N-acetylgalactosaminidase (NAGA) deficiency is a very rare lysosomal storage disorder with atypical features. It is clinically heterogeneous with 3 main phenotypes: type I is an infantile-onset neuroaxonal dystrophy (609241); type II, also known as Kanzaki disease, is an adult-onset disorder characterized by angiokeratoma corporis diffusum and mild intellectual impairment; and type III is an intermediate disorder (see 609241) with mild to moderate neurologic manifestations (Desnick and Schindler, 2001).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/324539">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_325051"><div><strong>CARASIL syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>325051</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1838577</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">HTRA1 disorder is a phenotypic spectrum in which some individuals have few to no symptoms and others manifest with the more severe CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) phenotype. Those who have a heterozygous HTRA1 pathogenic variant may have mild neurologic findings (sometimes identified only on neuroimaging) or mild-to-moderate neurologic signs and symptoms of CARASIL. In this chapter, the term "classic CARASIL" refers to the more severe phenotype associated with biallelic pathogenic variants, and "HTRA1 cerebral small vessel disease" (HTRA1-CSVD) refers to the milder phenotype associated with a heterozygous HTRA1 pathogenic variant. Classic CARASIL is characterized by early-onset changes in the deep white matter of the brain observed on MRI, and associated neurologic findings. The most frequent initial symptom is gait disturbance from spasticity beginning between ages 20 and 40 years. Forty-four percent of affected individuals have stroke-like episodes before age 40 years. Mood changes (apathy and irritability), pseudobulbar palsy, and cognitive dysfunction begin between ages 20 and 50 years. The disease progresses slowly following the onset of neurologic symptoms. Scalp alopecia and acute mid- to lower-back pain (lumbago) before age 30 years are characteristic. The most frequent initial symptom in individuals with HTRA1-CSVD is slowly progressive gait disturbance after age 40 years, which may be followed by the development of mood changes and cognitive dysfunction. A majority of affected individuals have a stroke-like episode after age 40 years. Spondylosis and alopecia are seen in a minority of individuals with HTRA1-CSVD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/325051">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_382033"><div><strong>Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>382033</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2673195</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The spectrum of COL4A1-related disorders includes: small-vessel brain disease of varying severity including porencephaly, variably associated with eye defects (retinal arterial tortuosity, Axenfeld-Rieger anomaly, cataract) and systemic findings (kidney involvement, muscle cramps, cerebral aneurysms, Raynaud phenomenon, cardiac arrhythmia, and hemolytic anemia). On imaging studies, small-vessel brain disease is manifest as diffuse periventricular leukoencephalopathy, lacunar infarcts, microhemorrhage, dilated perivascular spaces, and deep intracerebral hemorrhages. Clinically, small-vessel brain disease manifests as infantile hemiparesis, seizures, single or recurrent hemorrhagic stroke, ischemic stroke, and isolated migraine with aura. Porencephaly (fluid-filled cavities in the brain detected by CT or MRI) is typically manifest as infantile hemiparesis, seizures, and intellectual disability; however, on occasion it can be an incidental finding. HANAC (hereditary angiopathy with nephropathy, aneurysms, and muscle cramps) syndrome usually associates asymptomatic small-vessel brain disease, cerebral large vessel involvement (i.e., aneurysms), and systemic findings involving the kidney, muscle, and small vessels of the eye. Two additional phenotypes include isolated retinal artery tortuosity and nonsyndromic autosomal dominant congenital cataract.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/382033">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_895965"><div><strong>Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>895965</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C4225211</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">HTRA1 disorder is a phenotypic spectrum in which some individuals have few to no symptoms and others manifest with the more severe CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) phenotype. Those who have a heterozygous HTRA1 pathogenic variant may have mild neurologic findings (sometimes identified only on neuroimaging) or mild-to-moderate neurologic signs and symptoms of CARASIL. In this chapter, the term "classic CARASIL" refers to the more severe phenotype associated with biallelic pathogenic variants, and "HTRA1 cerebral small vessel disease" (HTRA1-CSVD) refers to the milder phenotype associated with a heterozygous HTRA1 pathogenic variant. Classic CARASIL is characterized by early-onset changes in the deep white matter of the brain observed on MRI, and associated neurologic findings. The most frequent initial symptom is gait disturbance from spasticity beginning between ages 20 and 40 years. Forty-four percent of affected individuals have stroke-like episodes before age 40 years. Mood changes (apathy and irritability), pseudobulbar palsy, and cognitive dysfunction begin between ages 20 and 50 years. The disease progresses slowly following the onset of neurologic symptoms. Scalp alopecia and acute mid- to lower-back pain (lumbago) before age 30 years are characteristic. The most frequent initial symptom in individuals with HTRA1-CSVD is slowly progressive gait disturbance after age 40 years, which may be followed by the development of mood changes and cognitive dysfunction. A majority of affected individuals have a stroke-like episode after age 40 years. Spondylosis and alopecia are seen in a minority of individuals with HTRA1-CSVD.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/895965">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1634330"><div><strong>Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1634330</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551768</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is characterized by mid-adult onset of recurrent ischemic stroke, cognitive decline progressing to dementia, a history of migraine with aura, mood disturbance, apathy, and diffuse white matter lesions and subcortical infarcts on neuroimaging.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1634330">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1677948"><div><strong>Brain small vessel disease 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1677948</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193053</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Brain small vessel disease-3 (BSVD3) is an autosomal recessive disorder resulting from fragility of cerebral vessels causing an increased risk of intracranial bleeding. The resultant phenotype is highly variable depending on timing and location of the intracranial bleed. Some patients may have onset in utero or early infancy, with subsequent global developmental delay, spasticity, and porencephaly on brain imaging. Other patients may have normal or mildly delayed development with sudden onset of intracranial hemorrhage causing acute neurologic deterioration (summary by Miyatake et al., 2018). For a discussion of genetic heterogeneity of brain small vessel disease, see BSVD1 (175780).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1677948">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1674537"><div><strong>Oculocerebrodental syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1674537</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5193101</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Oculoskeletodental syndrome (OCSKD) is characterized by congenital cataract, short stature and various skeletal anomalies, dysmorphic facial features and dental anomalies, developmental delay, and stroke. Other recurrent features include hearing loss, secondary glaucoma, and nephrocalcinosis (Tiosano et al., 2019).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1674537">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_324539" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Alpha-N-acetylgalactosaminidase deficiency type 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_382033" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant familial hematuria-retinal arteriolar tortuosity-contractures syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1677948" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Brain small vessel disease 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_325051" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">CARASIL syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1634330" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_895965" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1674537" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oculocerebrodental syndrome</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151838">Treatment Approaches to Lacunar Stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Das AS,
|
||
Regenhardt RW,
|
||
Feske SK,
|
||
Gurol ME</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2019 Aug;28(8):2055-2078.
|
||
Epub 2019 May 28
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2019.05.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151838" target="_blank">31151838</a><a href="/pmc/articles/PMC7456600" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25727737">Pharmacological treatment and prevention of cerebral small vessel disease: a review of potential interventions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bath PM,
|
||
Wardlaw JM</span><br />
|
||
<span class="medgenPMjournal">Int J Stroke</span>
|
||
2015 Jun;10(4):469-78.
|
||
Epub 2015 Mar 2
|
||
doi: 10.1111/ijs.12466.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25727737" target="_blank">25727737</a><a href="/pmc/articles/PMC4832291" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/1344131">Lacunar stroke: diagnosis, evaluation, and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fisher M,
|
||
Minematsu K</span><br />
|
||
<span class="medgenPMjournal">Heart Dis Stroke</span>
|
||
1992 Nov-Dec;1(6):353-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/1344131" target="_blank">1344131</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22lacunar%20stroke%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (26)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38380638">European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wardlaw JM,
|
||
Chabriat H,
|
||
de Leeuw FE,
|
||
Debette S,
|
||
Dichgans M,
|
||
Doubal F,
|
||
Jokinen H,
|
||
Katsanos AH,
|
||
Ornello R,
|
||
Pantoni L,
|
||
Pasi M,
|
||
Pavlovic AM,
|
||
Rudilosso S,
|
||
Schmidt R,
|
||
Staals J,
|
||
Taylor-Rowan M,
|
||
Hussain S,
|
||
Lindgren AG</span><br />
|
||
<span class="medgenPMjournal">Eur Stroke J</span>
|
||
2024 Mar;9(1):5-68.
|
||
Epub 2024 Feb 21
|
||
doi: 10.1177/23969873231219416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38380638" target="_blank">38380638</a><a href="/pmc/articles/PMC10916806" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36575578">Cerebral small vessel disease: Recent advances and future directions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Markus HS,
|
||
de Leeuw FE</span><br />
|
||
<span class="medgenPMjournal">Int J Stroke</span>
|
||
2023 Jan;18(1):4-14.
|
||
doi: 10.1177/17474930221144911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36575578" target="_blank">36575578</a><a href="/pmc/articles/PMC9806465" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151838">Treatment Approaches to Lacunar Stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Das AS,
|
||
Regenhardt RW,
|
||
Feske SK,
|
||
Gurol ME</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2019 Aug;28(8):2055-2078.
|
||
Epub 2019 May 28
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2019.05.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151838" target="_blank">31151838</a><a href="/pmc/articles/PMC7456600" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30602355">Cholesterol Lowering and Prevention of Stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hackam DG,
|
||
Hegele RA</span><br />
|
||
<span class="medgenPMjournal">Stroke</span>
|
||
2019 Feb;50(2):537-541.
|
||
doi: 10.1161/STROKEAHA.118.023167.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30602355" target="_blank">30602355</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30167649">Advances in Understanding the Pathophysiology of Lacunar Stroke: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Regenhardt RW,
|
||
Das AS,
|
||
Lo EH,
|
||
Caplan LR</span><br />
|
||
<span class="medgenPMjournal">JAMA Neurol</span>
|
||
2018 Oct 1;75(10):1273-1281.
|
||
doi: 10.1001/jamaneurol.2018.1073.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30167649" target="_blank">30167649</a><a href="/pmc/articles/PMC7426021" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lacunar%20stroke%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (994)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36575578">Cerebral small vessel disease: Recent advances and future directions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Markus HS,
|
||
de Leeuw FE</span><br />
|
||
<span class="medgenPMjournal">Int J Stroke</span>
|
||
2023 Jan;18(1):4-14.
|
||
doi: 10.1177/17474930221144911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36575578" target="_blank">36575578</a><a href="/pmc/articles/PMC9806465" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31151838">Treatment Approaches to Lacunar Stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Das AS,
|
||
Regenhardt RW,
|
||
Feske SK,
|
||
Gurol ME</span><br />
|
||
<span class="medgenPMjournal">J Stroke Cerebrovasc Dis</span>
|
||
2019 Aug;28(8):2055-2078.
|
||
Epub 2019 May 28
|
||
doi: 10.1016/j.jstrokecerebrovasdis.2019.05.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31151838" target="_blank">31151838</a><a href="/pmc/articles/PMC7456600" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31142635">CNS small vessel disease: A clinical review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cannistraro RJ,
|
||
Badi M,
|
||
Eidelman BH,
|
||
Dickson DW,
|
||
Middlebrooks EH,
|
||
Meschia JF</span><br />
|
||
<span class="medgenPMjournal">Neurology</span>
|
||
2019 Jun 11;92(24):1146-1156.
|
||
Epub 2019 May 29
|
||
doi: 10.1212/WNL.0000000000007654.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31142635" target="_blank">31142635</a><a href="/pmc/articles/PMC6598791" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28490287">Cheiro-oral syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Saeed M,
|
||
Abbker A,
|
||
Brenan P,
|
||
Abkur TM</span><br />
|
||
<span class="medgenPMjournal">Scott Med J</span>
|
||
2017 May;62(2):64-65.
|
||
Epub 2017 May 10
|
||
doi: 10.1177/0036933017691692.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28490287" target="_blank">28490287</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26300647">Secondary stroke prevention: challenges and solutions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Esenwa C,
|
||
Gutierrez J</span><br />
|
||
<span class="medgenPMjournal">Vasc Health Risk Manag</span>
|
||
2015;11:437-50.
|
||
Epub 2015 Aug 7
|
||
doi: 10.2147/VHRM.S63791.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26300647" target="_blank">26300647</a><a href="/pmc/articles/PMC4536764" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lacunar%20stroke%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (527)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38380638">European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wardlaw JM,
|
||
Chabriat H,
|
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<div class="nl"><a target="_blank" href="/pubmed/26300647">Secondary stroke prevention: challenges and solutions.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/19210194">Lacunar stroke.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Arboix A,
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<div class="nl"><a target="_blank" href="/pubmed/10408548">Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST).</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Adams HP Jr,
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Davis PH,
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Leira EC,
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Chang KC,
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Bendixen BH,
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Clarke WR,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lacunar%20stroke%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (532)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35676196">Neuroimaging in small vessel disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mena Romo L,
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Gómez-Choco M</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/30167649">Advances in Understanding the Pathophysiology of Lacunar Stroke: A Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Regenhardt RW,
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Das AS,
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Lo EH,
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Caplan LR</span><br />
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|
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<div class="nl"><a target="_blank" href="/pubmed/26300647">Secondary stroke prevention: challenges and solutions.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Esenwa C,
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Gutierrez J</span><br />
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<span class="medgenPMjournal">Vasc Health Risk Manag</span>
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2015;11:437-50.
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doi: 10.2147/VHRM.S63791.
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<div class="nl"><a target="_blank" href="/pubmed/25165388">Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Staals J,
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Makin SD,
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Doubal FN,
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Dennis MS,
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Wardlaw JM</span><br />
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||
<div class="nl"><a target="_blank" href="/pubmed/10408548">Baseline NIH Stroke Scale score strongly predicts outcome after stroke: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST).</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Adams HP Jr,
|
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Davis PH,
|
||
Leira EC,
|
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Chang KC,
|
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Bendixen BH,
|
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Clarke WR,
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Woolson RF,
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Hansen MD</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/10408548" target="_blank">10408548</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lacunar%20stroke%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (622)</a></div></div>
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</div>
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||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38380638">European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wardlaw JM,
|
||
Chabriat H,
|
||
de Leeuw FE,
|
||
Debette S,
|
||
Dichgans M,
|
||
Doubal F,
|
||
Jokinen H,
|
||
Katsanos AH,
|
||
Ornello R,
|
||
Pantoni L,
|
||
Pasi M,
|
||
Pavlovic AM,
|
||
Rudilosso S,
|
||
Schmidt R,
|
||
Staals J,
|
||
Taylor-Rowan M,
|
||
Hussain S,
|
||
Lindgren AG</span><br />
|
||
<span class="medgenPMjournal">Eur Stroke J</span>
|
||
2024 Mar;9(1):5-68.
|
||
Epub 2024 Feb 21
|
||
doi: 10.1177/23969873231219416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38380638" target="_blank">38380638</a><a href="/pmc/articles/PMC10916806" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36342528">Antiplatelet therapy for secondary prevention of lacunar stroke: a systematic review and network meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hou X,
|
||
Cen K,
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Cui Y,
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Zhang Y,
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||
Feng X</span><br />
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<span class="medgenPMjournal">Eur J Clin Pharmacol</span>
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2023 Jan;79(1):63-70.
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||
Epub 2022 Nov 7
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||
doi: 10.1007/s00228-022-03413-z.
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||
<span class="bold">PMID: </span><a href="/pubmed/36342528" target="_blank">36342528</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33185327">Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hamilton OKL,
|
||
Backhouse EV,
|
||
Janssen E,
|
||
Jochems ACC,
|
||
Maher C,
|
||
Ritakari TE,
|
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Stevenson AJ,
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Xia L,
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Deary IJ,
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Wardlaw JM</span><br />
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<span class="medgenPMjournal">Alzheimers Dement</span>
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2021 Apr;17(4):665-685.
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Epub 2020 Nov 13
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<span class="bold">PMID: </span><a href="/pubmed/33185327" target="_blank">33185327</a><a href="/pmc/articles/PMC8593445" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22329603">Pathology of lacunar ischemic stroke in humans--a systematic review.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Bailey EL,
|
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Smith C,
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Sudlow CL,
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Wardlaw JM</span><br />
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<span class="medgenPMjournal">Brain Pathol</span>
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2012 Sep;22(5):583-91.
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Epub 2012 Mar 16
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||
doi: 10.1111/j.1750-3639.2012.00575.x.
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||
<span class="bold">PMID: </span><a href="/pubmed/22329603" target="_blank">22329603</a><a href="/pmc/articles/PMC8057646" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17869382">Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Farrall AJ,
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Wardlaw JM</span><br />
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<span class="medgenPMjournal">Neurobiol Aging</span>
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<span class="bold">PMID: </span><a href="/pubmed/17869382" target="_blank">17869382</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lacunar%20stroke%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (31)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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