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<meta name="keywords" content="C3150733, disease or syndrome, kcnj5, kcnj5 long qt syndrome, long qt syndrome 13, long qt syndrome caused by mutation in kcnj5, long qt syndrome type 13, lqt13, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999).&#13; For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500)." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Long QT syndrome 13 (Concept Id: C3150733)
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<!--
UID=462083
ConceptID=C3150733
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Long QT syndrome 13<span class="h1sub">(LQT13)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>462083</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C3150733</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
<td>LQT13</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
Gene(s) directly associated with<br />
this condition or phenotype.</div></td>
<td><a target="_blank" title="KCNJ5 - ID: 3762 - NCBI Gene" href="/gene/3762" class="medgenPMinfo">KCNJ5</a> (11q24.3)</td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0013279" target="_blank">MONDO:0013279</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span>:</td>
<td><a href="https://omim.org/entry/613485" target="_blank">613485</a></td></tr>
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<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death (Jongbloed et al., 1999).&#13; For a discussion of genetic heterogeneity of long QT syndrome, see LQT1 (192500). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
</div>
<div class="portlet mgSection" id="ID_102">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
<div class="divPopper rprt" id="clin_13956"><div><strong>Atrioventricular block</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>13956</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0004245</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/13956">Feature record</a> | <a href="/medgen?term=%22Atrioventricular%20block%22%5BClinical%20Features%5D%20OR%2013956%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_5456"><div><strong>Cardiac arrest</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>5456</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0018790</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">An abrupt loss of heart function.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/5456">Feature record</a> | <a href="/medgen?term=%22Cardiac%20arrest%22%5BClinical%20Features%5D%20OR%205456%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_9169"><div><strong>Congestive heart failure</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9169</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0018802</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/9169">Feature record</a> | <a href="/medgen?term=%22Congestive%20heart%20failure%22%5BClinical%20Features%5D%20OR%209169%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_14579"><div><strong>Palpitations</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>14579</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0030252</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/14579">Feature record</a> | <a href="/medgen?term=%22Palpitations%22%5BClinical%20Features%5D%20OR%2014579%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_11027"><div><strong>Pulmonary embolism</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>11027</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0034065</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div></div>
<div class="spaceAbove">An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/11027">Feature record</a> | <a href="/medgen?term=%22Pulmonary%20embolism%22%5BClinical%20Features%5D%20OR%2011027%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_21443"><div><strong>Syncope</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21443</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0039070</a></dd><dt><span class="dotprefix"></span></dt><dd>Sign or Symptom</dd></dl></div></div></div>
<div class="spaceAbove">Syncope is a syndrome in which loss of consciousness is of relatively sudden onset, temporary (usually less than 1 to 2 minutes), self-terminating, and of usually rapid recovery. Syncope leads to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/21443">Feature record</a> | <a href="/medgen?term=%22Syncope%22%5BClinical%20Features%5D%20OR%2021443%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_21214"><div><strong>Torsades de pointes</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21214</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0040479</a></dd><dt><span class="dotprefix"></span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
<div class="spaceAbove">A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/21214">Feature record</a> | <a href="/medgen?term=%22Torsades%20de%20pointes%22%5BClinical%20Features%5D%20OR%2021214%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_294666"><div><strong>Prolonged QTc interval</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>294666</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C1560305</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div></div>
<div class="spaceAbove">A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/294666">Feature record</a> | <a href="/medgen?term=%22Prolonged%20QTc%20interval%22%5BClinical%20Features%5D%20OR%20294666%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_750308"><div><strong>Permanent atrial fibrillation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>750308</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C2586056</a></dd><dt><span class="dotprefix"></span></dt><dd>Pathologic Function</dd></dl></div></div></div>
<div class="spaceAbove">Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/750308">Feature record</a> | <a href="/medgen?term=%22Permanent%20atrial%20fibrillation%22%5BClinical%20Features%5D%20OR%20750308%5Buid%5D">Search on this feature</a></div></div>
<div class="divPopper rprt" id="clin_868398"><div><strong>Reduced left ventricular ejection fraction</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868398</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C4022792</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/868398">Feature record</a> | <a href="/medgen?term=%22Reduced%20left%20ventricular%20ejection%20fraction%22%5BClinical%20Features%5D%20OR%20868398%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_13956" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Atrioventricular block</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_5456" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cardiac arrest</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_9169" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Congestive heart failure</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_14579" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Palpitations</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_750308" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Permanent atrial fibrillation</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_294666" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Prolonged QTc interval</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_11027" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonary embolism</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868398" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Reduced left ventricular ejection fraction</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21443" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Syncope</a></span></li><li class="TLline">
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21214" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Torsades de pointes</a></span></li></ul></li></ul></div></div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0023976[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=44193">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=44193">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=44193" ref="ncbi_uid=44193">V</a></span></span><span class="TLline"><a href="/medgen/44193" ref="tree=GTR&amp;ncbi_uid=44193&amp;link_uid=44193" title="View MedGen record for 'Long QT syndrome'">Long QT syndrome</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1141890[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=685787">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=685787" ref="ncbi_uid=685787">V</a></span></span><span class="TLline"><a href="/medgen/685787" ref="tree=GTR&amp;ncbi_uid=685787&amp;link_uid=685787" title="View MedGen record for 'Congenital long QT syndrome'">Congenital long QT syndrome</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4551647[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=1641146">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=1641146" target="_blank" href="/omim/192500">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=1641146">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=1641146" ref="ncbi_uid=1641146">V</a></span></span><span class="TLline"><a href="/medgen/1641146" ref="tree=GTR&amp;ncbi_uid=1641146&amp;link_uid=1641146" title="View MedGen record for 'Long QT syndrome 1'">Long QT syndrome 1</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3150943[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=462293">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462293" target="_blank" href="/omim/152427">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=462293">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=462293" ref="ncbi_uid=462293">V</a></span></span><span class="TLline"><a href="/medgen/462293" ref="tree=GTR&amp;ncbi_uid=462293&amp;link_uid=462293" title="View MedGen record for 'Long QT syndrome 2'">Long QT syndrome 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1859062[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=349087">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=349087" target="_blank" href="/omim/600163">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=349087">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=349087" ref="ncbi_uid=349087">V</a></span></span><span class="TLline"><a href="/medgen/349087" ref="tree=GTR&amp;ncbi_uid=349087&amp;link_uid=349087" title="View MedGen record for 'Long QT syndrome 3'">Long QT syndrome 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1867904[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=358092">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=358092" target="_blank" href="/omim/176261">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=358092">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=358092" ref="ncbi_uid=358092">V</a></span></span><span class="TLline"><a href="/medgen/358092" ref="tree=GTR&amp;ncbi_uid=358092&amp;link_uid=358092" title="View MedGen record for 'Long QT syndrome 5'">Long QT syndrome 5</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3150953[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=462303">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462303" target="_blank" href="/omim/603796">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=462303">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=462303" ref="ncbi_uid=462303">V</a></span></span><span class="TLline"><a href="/medgen/462303" ref="tree=GTR&amp;ncbi_uid=462303&amp;link_uid=462303" title="View MedGen record for 'Long QT syndrome 6'">Long QT syndrome 6</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2678485[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=395635">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=395635" target="_blank" href="/omim/152427">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=395635">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=395635" ref="ncbi_uid=395635">V</a></span></span><span class="TLline"><a href="/medgen/395635" ref="tree=GTR&amp;ncbi_uid=395635&amp;link_uid=395635" title="View MedGen record for 'Long QT syndrome 9'">Long QT syndrome 9</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2678484[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=394836">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=394836" target="_blank" href="/omim/608256">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=394836">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=394836" ref="ncbi_uid=394836">V</a></span></span><span class="TLline"><a href="/medgen/394836" ref="tree=GTR&amp;ncbi_uid=394836&amp;link_uid=394836" title="View MedGen record for 'Long QT syndrome 10'">Long QT syndrome 10</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2678483[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=437218">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=437218" target="_blank" href="/omim/604001">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=437218">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=437218" ref="ncbi_uid=437218">V</a></span></span><span class="TLline"><a href="/medgen/437218" ref="tree=GTR&amp;ncbi_uid=437218&amp;link_uid=437218" title="View MedGen record for 'Long QT syndrome 11'">Long QT syndrome 11</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751830[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=442824">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=442824" target="_blank" href="/omim/601017">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=442824">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=442824" ref="ncbi_uid=442824">V</a></span></span><span class="TLline"><a href="/medgen/442824" ref="tree=GTR&amp;ncbi_uid=442824&amp;link_uid=442824" title="View MedGen record for 'Long QT syndrome 12'">Long QT syndrome 12</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3150733[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=462083">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=462083" target="_blank" href="/omim/600734">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1129/" ref="ncbi_uid=462083">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=462083" ref="ncbi_uid=462083">V</a></span></span><span class="TLline">Long QT syndrome 13</span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0022387[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=5929">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=5929" target="_blank" href="/omim/220400">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1405/" ref="ncbi_uid=5929">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=5929" ref="ncbi_uid=5929">V</a></span></span><span class="TLline"><a href="/medgen/5929" ref="tree=GTR&amp;ncbi_uid=5929&amp;link_uid=5929" title="View MedGen record for 'Jervell and Lange-Nielsen syndrome'">Jervell and Lange-Nielsen syndrome</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="TLline"><a href="/medgen/685787" ref="tree=MeSH" title="MedGen record for Congenital long QT syndrome">Congenital long QT syndrome</a></span><ul><li><span class="matched_ds">Long QT syndrome 13</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/38446445">Deep Learning-Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Jiang R,
Cheung CC,
Garcia-Montero M,
Davies B,
Cao J,
Redfearn D,
Laksman ZM,
Grondin S,
Atallah J,
Escudero CA,
Cadrin-Tourigny J,
Sanatani S,
Steinberg C,
Joza J,
Avram R,
Tadros R,
Krahn AD</span><br />
<span class="medgenPMjournal">JAMA Cardiol</span>
2024 Apr 1;9(4):377-384.
doi: 10.1001/jamacardio.2024.0039.
<span class="bold">PMID: </span><a href="/pubmed/38446445" target="_blank">38446445</a><a href="/pmc/articles/PMC10918571" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32931318">Temporal Trends in Arrhythmogenicity Related to Treatment of COVID-19 Infection.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hummel JP,
Maraj I,
Taoutel R,
Chamoun R,
Workman VK,
Tran L,
Abboud JM,
Afif C,
Chouairi S,
Delvecchio A,
Howes CJ,
Enriquez AD,
Akar JG</span><br />
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
2020 Oct;13(10):e008841.
Epub 2020 Sep 15
doi: 10.1161/CIRCEP.120.008841.
<span class="bold">PMID: </span><a href="/pubmed/32931318" target="_blank">32931318</a><a href="/pmc/articles/PMC7566294" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23511927">Clinical utility gene card for: long-QT syndrome (types 1-13).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Beckmann BM,
Wilde AA,
Kääb S</span><br />
<span class="medgenPMjournal">Eur J Hum Genet</span>
2013 Oct;21(10)
Epub 2013 Mar 20
doi: 10.1038/ejhg.2013.28.
<span class="bold">PMID: </span><a href="/pubmed/23511927" target="_blank">23511927</a><a href="/pmc/articles/PMC3778358" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(long%20qt%20syndrome%2013)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (71)</a></div></div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/34505884">Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzanti A,
Trancuccio A,
Kukavica D,
Pagan E,
Wang M,
Mohsin M,
Peterson D,
Bagnardi V,
Zareba W,
Priori SG</span><br />
<span class="medgenPMjournal">Europace</span>
2022 Apr 5;24(4):614-619.
doi: 10.1093/europace/euab238.
<span class="bold">PMID: </span><a href="/pubmed/34505884" target="_blank">34505884</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27291509">Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Enriquez A,
Antzelevitch C,
Bismah V,
Baranchuk A</span><br />
<span class="medgenPMjournal">Heart Rhythm</span>
2016 Sep;13(9):1878-84.
Epub 2016 Jun 9
doi: 10.1016/j.hrthm.2016.06.008.
<span class="bold">PMID: </span><a href="/pubmed/27291509" target="_blank">27291509</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
Jaynes HA,
Kingery JR,
Mourad NA,
Trujillo TN,
Overholser BR,
Kovacs RJ</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
2013 Jul;6(4):479-87.
Epub 2013 May 28
doi: 10.1161/CIRCOUTCOMES.113.000152.
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21789574">Genetics of sudden cardiac death.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barsheshet A,
Brenyo A,
Moss AJ,
Goldenberg I</span><br />
<span class="medgenPMjournal">Curr Cardiol Rep</span>
2011 Oct;13(5):364-76.
doi: 10.1007/s11886-011-0209-y.
<span class="bold">PMID: </span><a href="/pubmed/21789574" target="_blank">21789574</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20544339">HERG1 channelopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sanguinetti MC</span><br />
<span class="medgenPMjournal">Pflugers Arch</span>
2010 Jul;460(2):265-76.
Epub 2009 Nov 22
doi: 10.1007/s00424-009-0758-8.
<span class="bold">PMID: </span><a href="/pubmed/20544339" target="_blank">20544339</a><a href="/pmc/articles/PMC2886309" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (675)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/35154130">Autoantibody:Autoantigen Competitor Decoys: Application to Cardiac Phenotypes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Cardozo T,
Cardozo L,
Boutjdir M</span><br />
<span class="medgenPMjournal">Front Immunol</span>
2022;13:812649.
Epub 2022 Jan 28
doi: 10.3389/fimmu.2022.812649.
<span class="bold">PMID: </span><a href="/pubmed/35154130" target="_blank">35154130</a><a href="/pmc/articles/PMC8832015" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34505884">Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzanti A,
Trancuccio A,
Kukavica D,
Pagan E,
Wang M,
Mohsin M,
Peterson D,
Bagnardi V,
Zareba W,
Priori SG</span><br />
<span class="medgenPMjournal">Europace</span>
2022 Apr 5;24(4):614-619.
doi: 10.1093/europace/euab238.
<span class="bold">PMID: </span><a href="/pubmed/34505884" target="_blank">34505884</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33516393">Atrial Fibrillation in Inherited Channelopathies.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Azaam B,
Darbar D</span><br />
<span class="medgenPMjournal">Card Electrophysiol Clin</span>
2021 Mar;13(1):155-163.
Epub 2021 Jan 8
doi: 10.1016/j.ccep.2020.10.004.
<span class="bold">PMID: </span><a href="/pubmed/33516393" target="_blank">33516393</a><a href="/pmc/articles/PMC9172630" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32893267">Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Walsh R,
Lahrouchi N,
Tadros R,
Kyndt F,
Glinge C,
Postema PG,
Amin AS,
Nannenberg EA,
Ware JS,
Whiffin N,
Mazzarotto F,
Škorić-Milosavljević D,
Krijger C,
Arbelo E,
Babuty D,
Barajas-Martinez H,
Beckmann BM,
Bézieau S,
Bos JM,
Breckpot J,
Campuzano O,
Castelletti S,
Celen C,
Clauss S,
Corveleyn A,
Crotti L,
Dagradi F,
de Asmundis C,
Denjoy I,
Dittmann S,
Ellinor PT,
Ortuño CG,
Giustetto C,
Gourraud JB,
Hazeki D,
Horie M,
Ishikawa T,
Itoh H,
Kaneko Y,
Kanters JK,
Kimoto H,
Kotta MC,
Krapels IPC,
Kurabayashi M,
Lazarte J,
Leenhardt A,
Loeys BL,
Lundin C,
Makiyama T,
Mansourati J,
Martins RP,
Mazzanti A,
Mörner S,
Napolitano C,
Ohkubo K,
Papadakis M,
Rudic B,
Molina MS,
Sacher F,
Sahin H,
Sarquella-Brugada G,
Sebastiano R,
Sharma S,
Sheppard MN,
Shimamoto K,
Shoemaker MB,
Stallmeyer B,
Steinfurt J,
Tanaka Y,
Tester DJ,
Usuda K,
van der Zwaag PA,
Van Dooren S,
Van Laer L,
Winbo A,
Winkel BG,
Yamagata K,
Zumhagen S,
Volders PGA,
Lubitz SA,
Antzelevitch C,
Platonov PG,
Odening KE,
Roden DM,
Roberts JD,
Skinner JR,
Tfelt-Hansen J,
van den Berg MP,
Olesen MS,
Lambiase PD,
Borggrefe M,
Hayashi K,
Rydberg A,
Nakajima T,
Yoshinaga M,
Saenen JB,
Kääb S,
Brugada P,
Robyns T,
Giachino DF,
Ackerman MJ,
Brugada R,
Brugada J,
Gimeno JR,
Hasdemir C,
Guicheney P,
Priori SG,
Schulze-Bahr E,
Makita N,
Schwartz PJ,
Shimizu W,
Aiba T,
Schott JJ,
Redon R,
Ohno S,
Probst V;
Nantes Referral Center for inherited cardiac arrhythmia,
Behr ER,
Barc J,
Bezzina CR</span><br />
<span class="medgenPMjournal">Genet Med</span>
2021 Jan;23(1):47-58.
Epub 2020 Sep 7
doi: 10.1038/s41436-020-00946-5.
<span class="bold">PMID: </span><a href="/pubmed/32893267" target="_blank">32893267</a><a href="/pmc/articles/PMC7790744" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21474458">Drunk potassium channels.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nia AM,
Gassanov N,
Ortega M,
Er F</span><br />
<span class="medgenPMjournal">Europace</span>
2011 Sep;13(9):1352-3.
Epub 2011 Apr 6
doi: 10.1093/europace/eur100.
<span class="bold">PMID: </span><a href="/pubmed/21474458" target="_blank">21474458</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (467)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/32702997">IL-6 (Interleukin 6) Blockade and Heart Rate Corrected QT Interval Prolongation in COVID-19.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lazzerini PE,
Laghi-Pasini F,
Acampa M,
Boutjdir M,
Leopoldo Capecchi P</span><br />
<span class="medgenPMjournal">Circ Arrhythm Electrophysiol</span>
2020 Sep;13(9):e008791.
Epub 2020 Jul 23
doi: 10.1161/CIRCEP.120.008791.
<span class="bold">PMID: </span><a href="/pubmed/32702997" target="_blank">32702997</a><a href="/pmc/articles/PMC7482616" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31685385">The merits of the ICD for inherited heart rhythm disorders: A critical re-appraisal.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roston TM,
Krahn AD,
Ong K,
Sanatani S</span><br />
<span class="medgenPMjournal">Trends Cardiovasc Med</span>
2020 Oct;30(7):415-421.
Epub 2019 Oct 24
doi: 10.1016/j.tcm.2019.10.004.
<span class="bold">PMID: </span><a href="/pubmed/31685385" target="_blank">31685385</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21474458">Drunk potassium channels.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Nia AM,
Gassanov N,
Ortega M,
Er F</span><br />
<span class="medgenPMjournal">Europace</span>
2011 Sep;13(9):1352-3.
Epub 2011 Apr 6
doi: 10.1093/europace/eur100.
<span class="bold">PMID: </span><a href="/pubmed/21474458" target="_blank">21474458</a></div>
<div class="nl"><a target="_blank" href="/pubmed/15811869">The US Food and Drug Administration Cardiorenal Advisory Panel and the drug approval process.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roden DM,
Temple R</span><br />
<span class="medgenPMjournal">Circulation</span>
2005 Apr 5;111(13):1697-702.
doi: 10.1161/01.CIR.0000161370.77463.0F.
<span class="bold">PMID: </span><a href="/pubmed/15811869" target="_blank">15811869</a></div>
<div class="nl"><a target="_blank" href="/pubmed/10212898">Safety of artemisinin and its derivatives. A review of published and unpublished clinical trials.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ribeiro IR,
Olliaro P</span><br />
<span class="medgenPMjournal">Med Trop (Mars)</span>
1998;58(3 Suppl):50-3.
<span class="bold">PMID: </span><a href="/pubmed/10212898" target="_blank">10212898</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (408)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/34505884">Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzanti A,
Trancuccio A,
Kukavica D,
Pagan E,
Wang M,
Mohsin M,
Peterson D,
Bagnardi V,
Zareba W,
Priori SG</span><br />
<span class="medgenPMjournal">Europace</span>
2022 Apr 5;24(4):614-619.
doi: 10.1093/europace/euab238.
<span class="bold">PMID: </span><a href="/pubmed/34505884" target="_blank">34505884</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31378668">Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshinaga D,
Baba S,
Makiyama T,
Shibata H,
Hirata T,
Akagi K,
Matsuda K,
Kohjitani H,
Wuriyanghai Y,
Umeda K,
Yamamoto Y,
Conklin BR,
Horie M,
Takita J,
Heike T</span><br />
<span class="medgenPMjournal">Stem Cell Reports</span>
2019 Aug 13;13(2):394-404.
Epub 2019 Aug 1
doi: 10.1016/j.stemcr.2019.06.007.
<span class="bold">PMID: </span><a href="/pubmed/31378668" target="_blank">31378668</a><a href="/pmc/articles/PMC6700479" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27383078">Management of survivors of cardiac arrest - the importance of genetic investigation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schwartz PJ,
Dagradi F</span><br />
<span class="medgenPMjournal">Nat Rev Cardiol</span>
2016 Sep;13(9):560-6.
Epub 2016 Jul 7
doi: 10.1038/nrcardio.2016.104.
<span class="bold">PMID: </span><a href="/pubmed/27383078" target="_blank">27383078</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
Jaynes HA,
Kingery JR,
Mourad NA,
Trujillo TN,
Overholser BR,
Kovacs RJ</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
2013 Jul;6(4):479-87.
Epub 2013 May 28
doi: 10.1161/CIRCOUTCOMES.113.000152.
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21789574">Genetics of sudden cardiac death.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barsheshet A,
Brenyo A,
Moss AJ,
Goldenberg I</span><br />
<span class="medgenPMjournal">Curr Cardiol Rep</span>
2011 Oct;13(5):364-76.
doi: 10.1007/s11886-011-0209-y.
<span class="bold">PMID: </span><a href="/pubmed/21789574" target="_blank">21789574</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (340)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/34505884">Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mazzanti A,
Trancuccio A,
Kukavica D,
Pagan E,
Wang M,
Mohsin M,
Peterson D,
Bagnardi V,
Zareba W,
Priori SG</span><br />
<span class="medgenPMjournal">Europace</span>
2022 Apr 5;24(4):614-619.
doi: 10.1093/europace/euab238.
<span class="bold">PMID: </span><a href="/pubmed/34505884" target="_blank">34505884</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31685385">The merits of the ICD for inherited heart rhythm disorders: A critical re-appraisal.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Roston TM,
Krahn AD,
Ong K,
Sanatani S</span><br />
<span class="medgenPMjournal">Trends Cardiovasc Med</span>
2020 Oct;30(7):415-421.
Epub 2019 Oct 24
doi: 10.1016/j.tcm.2019.10.004.
<span class="bold">PMID: </span><a href="/pubmed/31685385" target="_blank">31685385</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27383078">Management of survivors of cardiac arrest - the importance of genetic investigation.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Schwartz PJ,
Dagradi F</span><br />
<span class="medgenPMjournal">Nat Rev Cardiol</span>
2016 Sep;13(9):560-6.
Epub 2016 Jul 7
doi: 10.1038/nrcardio.2016.104.
<span class="bold">PMID: </span><a href="/pubmed/27383078" target="_blank">27383078</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
Jaynes HA,
Kingery JR,
Mourad NA,
Trujillo TN,
Overholser BR,
Kovacs RJ</span><br />
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
2013 Jul;6(4):479-87.
Epub 2013 May 28
doi: 10.1161/CIRCOUTCOMES.113.000152.
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/21789574">Genetics of sudden cardiac death.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Barsheshet A,
Brenyo A,
Moss AJ,
Goldenberg I</span><br />
<span class="medgenPMjournal">Curr Cardiol Rep</span>
2011 Oct;13(5):364-76.
doi: 10.1007/s11886-011-0209-y.
<span class="bold">PMID: </span><a href="/pubmed/21789574" target="_blank">21789574</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (398)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36863123">Implantable cardioverter-defibrillator in patients with inherited arrhythmia syndromes: A systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Medeiros P,
Santos M,
Arantes C,
Pereira VH,
Rocha S</span><br />
<span class="medgenPMjournal">Heart Lung</span>
2023 Jul-Aug;60:1-7.
Epub 2023 Feb 28
doi: 10.1016/j.hrtlng.2023.02.012.
<span class="bold">PMID: </span><a href="/pubmed/36863123" target="_blank">36863123</a></div>
<div class="nl"><a target="_blank" href="/pubmed/37850595">Life-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Lawley CM,
Tester M,
Sanatani S,
Prendiville T,
Beach CM,
Vinocur JM,
Horie M,
Uhm JS,
Khongphatthanayothin A,
Ayers MD,
Starling L,
Yoshida Y,
Shah MJ,
Skinner JR,
Turner C</span><br />
<span class="medgenPMjournal">Heart Rhythm</span>
2022 Nov;19(11):1826-1833.
Epub 2022 Oct 11
doi: 10.1016/j.hrthm.2022.08.003.
<span class="bold">PMID: </span><a href="/pubmed/37850595" target="_blank">37850595</a></div>
<div class="nl"><a target="_blank" href="/pubmed/34492005">The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Chan XHS,
Haeusler IL,
Win YN,
Pike J,
Hanboonkunupakarn B,
Hanafiah M,
Lee SJ,
Djimdé A,
Fanello CI,
Kiechel JR,
Lacerda MV,
Ogutu B,
Onyamboko MA,
Siqueira AM,
Ashley EA,
Taylor WR,
White NJ</span><br />
<span class="medgenPMjournal">PLoS Med</span>
2021 Sep;18(9):e1003766.
Epub 2021 Sep 7
doi: 10.1371/journal.pmed.1003766.
<span class="bold">PMID: </span><a href="/pubmed/34492005" target="_blank">34492005</a><a href="/pmc/articles/PMC8454971" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/29525134">Thoracoscopic Sympathectomy for Long QT Syndrome. Literature Review and Case Study.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Surman TL,
Stuklis RG,
Chan JC</span><br />
<span class="medgenPMjournal">Heart Lung Circ</span>
2019 Mar;28(3):486-494.
Epub 2018 Feb 13
doi: 10.1016/j.hlc.2018.02.005.
<span class="bold">PMID: </span><a href="/pubmed/29525134" target="_blank">29525134</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26385533">Implantable cardioverter-defibrillator harm in young patients with inherited arrhythmia syndromes: A systematic review and meta-analysis of inappropriate shocks and complications.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Olde Nordkamp LR,
Postema PG,
Knops RE,
van Dijk N,
Limpens J,
Wilde AA,
de Groot JR</span><br />
<span class="medgenPMjournal">Heart Rhythm</span>
2016 Feb;13(2):443-54.
Epub 2015 Sep 15
doi: 10.1016/j.hrthm.2015.09.010.
<span class="bold">PMID: </span><a href="/pubmed/26385533" target="_blank">26385533</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2013%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (25)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (2)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (46)</a></li>
<li><a href="/gtr/tests?term=C3150733%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (10)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3150733%5bDISCUI%5d" target="_blank">See all (49)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(long%20qt%20syndrome%2013)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Long+QT+syndrome+13/8766" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/long_qt_syndrome_13" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&amp;query=Long%20QT%20syndrome%2013" target="_blank">MedlinePlus</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/15666/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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