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<meta name="keywords" content="C0030920, acute peptic ulcer with haemorrhage, acute peptic ulcer with haemorrhage and perforation, acute peptic ulcer with hemorrhage, acute peptic ulcer with hemorrhage and perforation, acute peptic ulcer without haemorrhage and without perforation, acute peptic ulcer without hemorrhage and without perforation, disease or syndrome, gastroduodenal ulcer, gastroduodenal ulcers, peptic ulcer, peptic ulcer disease, peptic ulceration, peptic ulcers, pu - peptic ulcer, pud - peptic ulcer disease, sore in the lining of gastrointestinal tract, ulcer, gastroduodenal, ulcer, peptic, ulcers, gastroduodenal, ulcers, peptic, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the esophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=45384
|
||
ConceptID=C0030920
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Peptic ulcer</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45384</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0030920</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Gastroduodenal Ulcer; Gastroduodenal Ulcers; Peptic Ulcer; Peptic Ulcers; Ulcer, Gastroduodenal; Ulcer, Peptic; Ulcers, Gastroduodenal; Ulcers, Peptic</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Peptic ulcer disease (13200003); Peptic ulceration (13200003); PUD - Peptic ulcer disease (13200003); PU - Peptic ulcer (13200003); Peptic ulcer (13200003); Gastroduodenal ulcer (13200003)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004398">HP:0004398</a></td></tr>
|
||
<tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0004247" target="_blank">MONDO:0004247</a></td></tr>
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||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the esophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0030920[DISCUI]&test_type=Clinical" ref="ncbi_uid=45384">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Peptic ulcer</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/7130" ref="tree=MeSH" title="MedGen record for Intestinal disorder">Intestinal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/8502" ref="tree=MeSH" title="MedGen record for Duodenal disorder">Duodenal disorder</a></span><ul><li><span class="matched_ds">Peptic ulcer</span><ul><li><span class="TLline"><a href="/medgen/353357" ref="tree=MeSH" title="MedGen record for Active Peptic Ulcer">Active Peptic Ulcer</a></span></li><li><span class="TLline"><a href="/medgen/41670" ref="tree=MeSH" title="MedGen record for Duodenal ulcer">Duodenal ulcer</a></span></li><li><span class="TLline"><a href="/medgen/21330" ref="tree=MeSH" title="MedGen record for Gastric ulcer">Gastric ulcer</a></span><ul><li><span class="TLline"><a href="/medgen/98321" ref="tree=MeSH" title="MedGen record for Stress ulcer of stomach">Stress ulcer of stomach</a></span></li></ul></li><li><span class="TLline"><a href="/medgen/5028" ref="tree=MeSH" title="MedGen record for Peptic esophagitis">Peptic esophagitis</a></span></li><li><span class="TLline"><a href="/medgen/45385" ref="tree=MeSH" title="MedGen record for Peptic ulcer perforation">Peptic ulcer perforation</a></span></li><li><span class="TLline"><a href="/medgen/439439" ref="tree=MeSH" title="MedGen record for Stress ulcer">Stress ulcer</a></span></li><li><span class="TLline"><a href="/medgen/53129" ref="tree=MeSH" title="MedGen record for Zollinger-Ellison syndrome">Zollinger-Ellison syndrome</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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</div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_9957"><div><strong>Multiple endocrine neoplasia, type 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>9957</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025267</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Multiple endocrine neoplasia type 1 (MEN1) includes varying combinations of more than 20 endocrine and non-endocrine tumors. Endocrine tumors become evident either by overproduction of hormones by the tumor or by growth of the tumor itself. Parathyroid tumors are the most common MEN1-associated endocrinopathy; onset in 90% of individuals is between ages 20 and 25 years with hypercalcemia evident by age 50 years; hypercalcemia causes lethargy, depression, confusion, anorexia, constipation, nausea, vomiting, diuresis, dehydration, hypercalciuria, kidney stones, increased bone resorption/fracture risk, hypertension, and shortened QT interval. Pituitary tumors include prolactinoma (the most common), which manifests as oligomenorrhea/amenorrhea and galactorrhea in females and sexual dysfunction in males. Well-differentiated endocrine tumors of the gastroenteropancreatic (GEP) tract can manifest as Zollinger-Ellison syndrome (gastrinoma); hypoglycemia (insulinoma); hyperglycemia, anorexia, glossitis, anemia, diarrhea, venous thrombosis, and skin rash (glucagonoma); and watery diarrhea, hypokalemia, and achlorhydria syndrome (vasoactive intestinal peptide [VIP]-secreting tumor). Carcinoid tumors are non-hormone-secreting and can manifest as a large mass after age 50 years. Adrenocortical tumors can be associated with primary hypercortisolism or hyperaldosteronism. Non-endocrine tumors include facial angiofibromas, collagenomas, lipomas, meningiomas, ependymomas, and leiomyomas.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/9957">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_322173"><div><strong>Familial hypocalciuric hypercalcemia 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322173</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1833372</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any familial hypocalciuric hypercalcemia in which the cause of the disease is a mutation in the AP2S1 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/322173">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_374447"><div><strong>Familial hypocalciuric hypercalcemia 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>374447</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1840347</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial hypocalciuric hypercalcemia type II (HHC2) is an autosomal dominant disorder characterized by lifelong elevations of serum calcium concentrations with low urinary calcium excretion and normal circulating parathyroid hormone concentrations in most patients. Patients are generally asymptomatic (summary by Nesbit et al., 2013). For a general phenotypic description and a discussion of genetic heterogeneity of hypocalciuric hypercalcemia, see HHC1 (145980).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/374447">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_338154"><div><strong>Gastrocutaneous syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>338154</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1850899</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A rare syndromic hyperpigmentation of the skin with characteristics of multiple lentigines and cafe-au-lait spots associated with hiatal hernia and peptic ulcer, hypertelorism and myopia. There have been no further descriptions in the literature since 1982.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/338154">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_347604"><div><strong>Wolfram syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347604</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1858028</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Wolfram syndrome-2 (WFS2) is an autosomal recessive neurodegenerative disorder characterized by diabetes mellitus, high frequency sensorineural hearing loss, optic atrophy or neuropathy, and defective platelet aggregation resulting in peptic ulcer bleeding (summary by Mozzillo et al., 2014). For a discussion of genetic heterogeneity of Wolfram syndrome, see WFS1 (222300).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347604">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_374447" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial hypocalciuric hypercalcemia 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_322173" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Familial hypocalciuric hypercalcemia 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_338154" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Gastrocutaneous syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_9957" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Multiple endocrine neoplasia, type 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_347604" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Wolfram syndrome 2</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33620586">Evidence-based clinical practice guidelines for peptic ulcer disease 2020.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kamada T,
|
||
Satoh K,
|
||
Itoh T,
|
||
Ito M,
|
||
Iwamoto J,
|
||
Okimoto T,
|
||
Kanno T,
|
||
Sugimoto M,
|
||
Chiba T,
|
||
Nomura S,
|
||
Mieda M,
|
||
Hiraishi H,
|
||
Yoshino J,
|
||
Takagi A,
|
||
Watanabe S,
|
||
Koike K</span><br />
|
||
<span class="medgenPMjournal">J Gastroenterol</span>
|
||
2021 Apr;56(4):303-322.
|
||
Epub 2021 Feb 23
|
||
doi: 10.1007/s00535-021-01769-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33620586" target="_blank">33620586</a><a href="/pmc/articles/PMC8005399" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30611829">Diagnosis and Treatment of Peptic Ulcer Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kavitt RT,
|
||
Lipowska AM,
|
||
Anyane-Yeboa A,
|
||
Gralnek IM</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
2019 Apr;132(4):447-456.
|
||
Epub 2019 Jan 3
|
||
doi: 10.1016/j.amjmed.2018.12.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30611829" target="_blank">30611829</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28071659">ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chey WD,
|
||
Leontiadis GI,
|
||
Howden CW,
|
||
Moss SF</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2017 Feb;112(2):212-239.
|
||
Epub 2017 Jan 10
|
||
doi: 10.1038/ajg.2016.563.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28071659" target="_blank">28071659</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22peptic%20ulcer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (1443)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31921329">Perforated and bleeding peptic ulcer: WSES guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tarasconi A,
|
||
Coccolini F,
|
||
Biffl WL,
|
||
Tomasoni M,
|
||
Ansaloni L,
|
||
Picetti E,
|
||
Molfino S,
|
||
Shelat V,
|
||
Cimbanassi S,
|
||
Weber DG,
|
||
Abu-Zidan FM,
|
||
Campanile FC,
|
||
Di Saverio S,
|
||
Baiocchi GL,
|
||
Casella C,
|
||
Kelly MD,
|
||
Kirkpatrick AW,
|
||
Leppaniemi A,
|
||
Moore EE,
|
||
Peitzman A,
|
||
Fraga GP,
|
||
Ceresoli M,
|
||
Maier RV,
|
||
Wani I,
|
||
Pattonieri V,
|
||
Perrone G,
|
||
Velmahos G,
|
||
Sugrue M,
|
||
Sartelli M,
|
||
Kluger Y,
|
||
Catena F</span><br />
|
||
<span class="medgenPMjournal">World J Emerg Surg</span>
|
||
2020;15:3.
|
||
Epub 2020 Jan 7
|
||
doi: 10.1186/s13017-019-0283-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31921329" target="_blank">31921329</a><a href="/pmc/articles/PMC6947898" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30611829">Diagnosis and Treatment of Peptic Ulcer Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kavitt RT,
|
||
Lipowska AM,
|
||
Anyane-Yeboa A,
|
||
Gralnek IM</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
2019 Apr;132(4):447-456.
|
||
Epub 2019 Jan 3
|
||
doi: 10.1016/j.amjmed.2018.12.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30611829" target="_blank">30611829</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30228726">Peptic Ulcer Disease and Helicobacter pylori infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Narayanan M,
|
||
Reddy KM,
|
||
Marsicano E</span><br />
|
||
<span class="medgenPMjournal">Mo Med</span>
|
||
2018 May-Jun;115(3):219-224.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30228726" target="_blank">30228726</a><a href="/pmc/articles/PMC6140150" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29745325">Lifestyle and Peptic Ulcer Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yegen BC</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2018;24(18):2034-2040.
|
||
doi: 10.2174/1381612824666180510092303.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29745325" target="_blank">29745325</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26460663">Perforated peptic ulcer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Søreide K,
|
||
Thorsen K,
|
||
Harrison EM,
|
||
Bingener J,
|
||
Møller MH,
|
||
Ohene-Yeboah M,
|
||
Søreide JA</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2015 Sep 26;386(10000):1288-1298.
|
||
doi: 10.1016/S0140-6736(15)00276-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26460663" target="_blank">26460663</a><a href="/pmc/articles/PMC4618390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peptic%20ulcer%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8857)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31921329">Perforated and bleeding peptic ulcer: WSES guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tarasconi A,
|
||
Coccolini F,
|
||
Biffl WL,
|
||
Tomasoni M,
|
||
Ansaloni L,
|
||
Picetti E,
|
||
Molfino S,
|
||
Shelat V,
|
||
Cimbanassi S,
|
||
Weber DG,
|
||
Abu-Zidan FM,
|
||
Campanile FC,
|
||
Di Saverio S,
|
||
Baiocchi GL,
|
||
Casella C,
|
||
Kelly MD,
|
||
Kirkpatrick AW,
|
||
Leppaniemi A,
|
||
Moore EE,
|
||
Peitzman A,
|
||
Fraga GP,
|
||
Ceresoli M,
|
||
Maier RV,
|
||
Wani I,
|
||
Pattonieri V,
|
||
Perrone G,
|
||
Velmahos G,
|
||
Sugrue M,
|
||
Sartelli M,
|
||
Kluger Y,
|
||
Catena F</span><br />
|
||
<span class="medgenPMjournal">World J Emerg Surg</span>
|
||
2020;15:3.
|
||
Epub 2020 Jan 7
|
||
doi: 10.1186/s13017-019-0283-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31921329" target="_blank">31921329</a><a href="/pmc/articles/PMC6947898" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30243454">Acid Peptic Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kempenich JW,
|
||
Sirinek KR</span><br />
|
||
<span class="medgenPMjournal">Surg Clin North Am</span>
|
||
2018 Oct;98(5):933-944.
|
||
doi: 10.1016/j.suc.2018.06.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30243454" target="_blank">30243454</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30228726">Peptic Ulcer Disease and Helicobacter pylori infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Narayanan M,
|
||
Reddy KM,
|
||
Marsicano E</span><br />
|
||
<span class="medgenPMjournal">Mo Med</span>
|
||
2018 May-Jun;115(3):219-224.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30228726" target="_blank">30228726</a><a href="/pmc/articles/PMC6140150" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26460663">Perforated peptic ulcer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Søreide K,
|
||
Thorsen K,
|
||
Harrison EM,
|
||
Bingener J,
|
||
Møller MH,
|
||
Ohene-Yeboah M,
|
||
Søreide JA</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2015 Sep 26;386(10000):1288-1298.
|
||
doi: 10.1016/S0140-6736(15)00276-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26460663" target="_blank">26460663</a><a href="/pmc/articles/PMC4618390" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3073908">Peptic ulcer disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Friedman G</span><br />
|
||
<span class="medgenPMjournal">Clin Symp</span>
|
||
1988;40(5):1-32.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3073908" target="_blank">3073908</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peptic%20ulcer%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6419)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/24833682">Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Narum S,
|
||
Westergren T,
|
||
Klemp M</span><br />
|
||
<span class="medgenPMjournal">BMJ Open</span>
|
||
2014 May 15;4(5):e004587.
|
||
doi: 10.1136/bmjopen-2013-004587.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24833682" target="_blank">24833682</a><a href="/pmc/articles/PMC4025450" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15988415">Peptic ulcer disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Harbison SP,
|
||
Dempsey DT</span><br />
|
||
<span class="medgenPMjournal">Curr Probl Surg</span>
|
||
2005 Jun;42(6):346-454.
|
||
doi: 10.1067/j.cpsurg.2005.02.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15988415" target="_blank">15988415</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12354485">Peptic-ulcer disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan FK,
|
||
Leung WK</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2002 Sep 21;360(9337):933-41.
|
||
doi: 10.1016/s0140-6736(02)11030-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12354485" target="_blank">12354485</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/3298137">Peptic ulcer disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Schirmer BD,
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<span class="bold">PMID: </span><a href="/pubmed/3298137" target="_blank">3298137</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/173997">Nonassociation of adrenocorticosteroid therapy and peptic ulcer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chalasani N,
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<div class="nl"><a target="_blank" href="/pubmed/14341156">SEASONAL AND MONTHLY INCIDENCE OF PEPTIC ULCER.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peptic%20ulcer%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4024)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/32242355">Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lau JYW,
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Yu Y,
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Chan HCH,
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Yip HC,
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Chan SM,
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Luk SWY,
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Wong SH,
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Lau LHS,
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Lui RN,
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<span class="bold">PMID: </span><a href="/pubmed/32242355" target="_blank">32242355</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28259716">An Unusual Cause of Acute Perforation.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Nassani N,
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Deeb L,
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2017 Apr;152(5):956-957.
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<span class="bold">PMID: </span><a href="/pubmed/28259716" target="_blank">28259716</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30427152">PREDICTORS OF FATAL OUTCOME IN PATIENTS WITH HEMORRHAGIC SHOCK IN GASTROINTESTINAL BLEEDING.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Girsh AO,
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Stukanov AM,
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Chernenko SV,
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Maksimishin SV,
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<span class="bold">PMID: </span><a href="/pubmed/30427152" target="_blank">30427152</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/18790438">Endoscopic haemostasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Aabakken L</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/18790438" target="_blank">18790438</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/15528022">Medical treatment of acute pancreatitis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Mayerle J,
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<span class="bold">PMID: </span><a href="/pubmed/15528022" target="_blank">15528022</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peptic%20ulcer%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3534)</a></div></div>
|
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|
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|
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|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/36897895">Impact of evidence-based bundles on ventilator-associated pneumonia prevention: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Da Rocha Gaspar MD,
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Antunes Rinaldi EC,
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Guetter Mello R,
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Dos Santos FA,
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Mendes Nadal J,
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Andreane Cabral LP,
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Vitor Farago P</span><br />
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2023 Feb 28;17(2):194-201.
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<span class="bold">PMID: </span><a href="/pubmed/36897895" target="_blank">36897895</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33620586">Evidence-based clinical practice guidelines for peptic ulcer disease 2020.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Kamada T,
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Satoh K,
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Itoh T,
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Ito M,
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Iwamoto J,
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Okimoto T,
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Kanno T,
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Sugimoto M,
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Chiba T,
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Nomura S,
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Mieda M,
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Hiraishi H,
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Yoshino J,
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Takagi A,
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Watanabe S,
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Epub 2021 Feb 23
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||
<span class="bold">PMID: </span><a href="/pubmed/33620586" target="_blank">33620586</a><a href="/pmc/articles/PMC8005399" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/29055500">Long-term Systemic Corticosteroid Exposure: A Systematic Literature Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rice JB,
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Scarpati LM,
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2017 Nov;39(11):2216-2229.
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Epub 2017 Oct 19
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<span class="bold">PMID: </span><a href="/pubmed/29055500" target="_blank">29055500</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/24833682">Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Narum S,
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Westergren T,
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Klemp M</span><br />
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<span class="medgenPMjournal">BMJ Open</span>
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2014 May 15;4(5):e004587.
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doi: 10.1136/bmjopen-2013-004587.
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<span class="bold">PMID: </span><a href="/pubmed/24833682" target="_blank">24833682</a><a href="/pmc/articles/PMC4025450" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20065566">Meckel's diverticulum-Revisited.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malik AA;
|
||
Shams-ul-Bari,
|
||
Wani KA,
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Khaja AR</span><br />
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<span class="medgenPMjournal">Saudi J Gastroenterol</span>
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doi: 10.4103/1319-3767.58760.
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<span class="bold">PMID: </span><a href="/pubmed/20065566" target="_blank">20065566</a><a href="/pmc/articles/PMC3023098" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peptic%20ulcer%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (213)</a></div></div>
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|
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0030920%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (3)</a></li>
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