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<!--
UID=45036
ConceptID=C0027662
-->
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Multiple endocrine neoplasia</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45036</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0027662</a></dd><dt><span class="dotprefix"></span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
<td>Adenomatoses, Familial Endocrine; Adenomatoses, Multiple Endocrine; Adenomatosis, Familial Endocrine; Adenomatosis, Multiple Endocrine; Adenopathies, Multiple Endocrine; Adenopathy, Multiple Endocrine; Endocrine Adenomatoses, Familial; Endocrine Adenomatoses, Multiple; Endocrine Adenomatosis, Familial; Endocrine Adenomatosis, Multiple; Endocrine Adenopathies, Multiple; Endocrine Adenopathy, Multiple; Endocrine Neoplasia, Multiple; Endocrine Neoplasms, Multiple; Familial Endocrine Adenomatoses; Familial Endocrine Adenomatosis; Multiple Endocrine Adenomatoses; Multiple Endocrine Adenomatosis; Multiple Endocrine Adenopathies; Multiple Endocrine Adenopathy; Multiple Endocrine Neoplasia; Multiple Endocrine Neoplasia Syndrome; Multiple Endocrine Neoplasia Syndromes; Multiple Endocrine Neoplasms; Neoplasia, Multiple Endocrine; Neoplasms, Multiple Endocrine</td></tr>
<tr><td><span class="bold">SNOMED CT: </span></td>
<td>Multiple endocrine adenomas (60549007); Endocrine adenomatosis (60549007); MEN - Multiple endocrine neoplasia (46724008); Multiple endocrine tumasia (46724008); MEA - Multiple endocrine adenomatosis (46724008); Familial polyendocrine adenomatosis (46724008); Multiple endocrine neoplasia (46724008)</td></tr>
<tr><td>Modes of inheritance:</td>
<td>
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">C0443147</a></dd><dt><span class="dotprefix"></span></dt><dd>Intellectual Product</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
<div class="divPopper rprt" id="moi_988794"><div><strong>Not genetically inherited</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>988794</dd><dt><span class="dotprefix"></span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms&#10;that cannot be identified in NLM's Unified Medical Language system (UMLS)&#10;Click for more information.">CN307044</a></dd><dt><span class="dotprefix"></span></dt><dd>Finding</dd></dl></div></div></div>
<div class="spaceAbove">Source: Orphanet</div>
<div class="spaceAbove">clinical entity without genetic inheritance.</div>
<div class="spaceAbove nowrap">See: <a href="/medgen/988794">This record</a></div></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div>
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_988794" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Not genetically inherited</a><span> (Orphanet)</span></div></td></tr>
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
<td><a href="https://monarchinitiative.org/disease/MONDO:0017169" target="_blank">MONDO:0017169</a></td></tr>
<tr><td>OMIM<span class="superscript">®</span> Phenotypic series:</td>
<td><a href="https://omim.org/phenotypicSeries/PS131100" target="_blank">PS131100</a></td></tr>
<tr><td>Orphanet:</td>
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&amp;Expert=276161">ORPHA276161</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
<div class="portlet mgSection" id="ID_100">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">Multiple endocrine neoplasia (MEN) is a group of rare inherited cancer syndromes characterized by the development of two or more endocrine gland tumors, sometimes with tumor development in other tissues or organs. [from <a title="Orphanet Rare Disease Ontology (ORDO)" href="http://www.orphadata.org/cgi-bin/inc/ordo_orphanet.inc.php" class="defSource" target="_blank">ORDO</a>]</div>
</div>
<div class="portlet mgSection" id="ID_118">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test,  </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test,  </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM,  </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>,  </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar  </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027662[DISCUI]&amp;test_type=Clinical" ref="ncbi_uid=45036">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&amp;from_uid=45036" ref="ncbi_uid=45036">V</a></span></span><span class="TLline">Multiple endocrine neoplasia</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/5527" ref="tree=MeSH" title="MedGen record for Hereditary disease">Hereditary disease</a></span><ul><li><span class="TLline"><a href="/medgen/14326" ref="tree=MeSH" title="MedGen record for Hereditary cancer-predisposing syndrome">Hereditary cancer-predisposing syndrome</a></span><ul><li><span class="matched_ds">Multiple endocrine neoplasia</span><ul><li><span class="TLline"><a href="/medgen/373469" ref="tree=MeSH" title="MedGen record for Multiple endocrine neoplasia type 4">Multiple endocrine neoplasia type 4</a></span></li><li><span class="TLline"><a href="/medgen/9958" ref="tree=MeSH" title="MedGen record for Multiple endocrine neoplasia type 2A">Multiple endocrine neoplasia type 2A</a></span></li><li><span class="TLline"><a href="/medgen/9959" ref="tree=MeSH" title="MedGen record for Multiple endocrine neoplasia type 2B">Multiple endocrine neoplasia type 2B</a></span></li><li><span class="TLline"><a href="/medgen/9957" ref="tree=MeSH" title="MedGen record for Multiple endocrine neoplasia, type 1">Multiple endocrine neoplasia, type 1</a></span></li><li><span class="TLline"><a href="/medgen/887211" ref="tree=MeSH" title="MedGen record for Multiple endocrine neoplasia, type 2">Multiple endocrine neoplasia, type 2</a></span><ul><li><span class="TLline"><a href="/medgen/322311" ref="tree=MeSH" title="MedGen record for Familial medullary thyroid carcinoma">Familial medullary thyroid carcinoma</a></span><ul><li><span class="TLline"><a href="/medgen/1756444" ref="tree=MeSH" title="MedGen record for Recurrent Hereditary Thyroid Gland Medullary Carcinoma">Recurrent Hereditary Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1764319" ref="tree=MeSH" title="MedGen record for Unresectable Hereditary Thyroid Gland Medullary Carcinoma">Unresectable Hereditary Thyroid Gland Medullary Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&amp;data_id=156&amp;PatId=20351&amp;search=Disease_Classif_Simple&amp;new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Multiple endocrine neoplasia</span> in Orphanet.</div></div></div>
</div>
<div class="portlet mgSection" id="ID_105">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
<div class="nl"><a target="_blank" href="/pubmed/34340212">Neuroendocrine and Adrenal Tumors, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Shah MH,
Goldner WS,
Benson AB,
Bergsland E,
Blaszkowsky LS,
Brock P,
Chan J,
Das S,
Dickson PV,
Fanta P,
Giordano T,
Halfdanarson TR,
Halperin D,
He J,
Heaney A,
Heslin MJ,
Kandeel F,
Kardan A,
Khan SA,
Kuvshinoff BW,
Lieu C,
Miller K,
Pillarisetty VG,
Reidy D,
Salgado SA,
Shaheen S,
Soares HP,
Soulen MC,
Strosberg JR,
Sussman CR,
Trikalinos NA,
Uboha NA,
Vijayvergia N,
Wong T,
Lynn B,
Hochstetler C</span><br />
<span class="medgenPMjournal">J Natl Compr Canc Netw</span>
2021 Jul 28;19(7):839-868.
doi: 10.6004/jnccn.2021.0032.
<span class="bold">PMID: </span><a href="/pubmed/34340212" target="_blank">34340212</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26363542">Multiple Endocrine Neoplasia: Genetics and Clinical Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Norton JA,
Krampitz G,
Jensen RT</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2015 Oct;24(4):795-832.
Epub 2015 Jul 27
doi: 10.1016/j.soc.2015.06.008.
<span class="bold">PMID: </span><a href="/pubmed/26363542" target="_blank">26363542</a><a href="/pmc/articles/PMC4571281" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22723327">Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thakker RV,
Newey PJ,
Walls GV,
Bilezikian J,
Dralle H,
Ebeling PR,
Melmed S,
Sakurai A,
Tonelli F,
Brandi ML;
Endocrine Society</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2012 Sep;97(9):2990-3011.
Epub 2012 Jun 20
doi: 10.1210/jc.2012-1230.
<span class="bold">PMID: </span><a href="/pubmed/22723327" target="_blank">22723327</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22multiple%20endocrine%20neoplasia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (326)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023</a></h3>
</div>
</div>
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
<div class="portlet mgSection" id="ID_103">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
<div class="nl"><a target="_blank" href="/pubmed/35319130">Update on the clinical management of multiple endocrine neoplasia type 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pieterman CRC,
Valk GD</span><br />
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
2022 Oct;97(4):409-423.
Epub 2022 Apr 1
doi: 10.1111/cen.14727.
<span class="bold">PMID: </span><a href="/pubmed/35319130" target="_blank">35319130</a><a href="/pmc/articles/PMC9540817" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/33812987">Multiple endocrine neoplasia type 2: A review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Mathiesen JS,
Effraimidis G,
Rossing M,
Rasmussen ÅK,
Hoejberg L,
Bastholt L,
Godballe C,
Oturai P,
Feldt-Rasmussen U</span><br />
<span class="medgenPMjournal">Semin Cancer Biol</span>
2022 Feb;79:163-179.
Epub 2021 Apr 1
doi: 10.1016/j.semcancer.2021.03.035.
<span class="bold">PMID: </span><a href="/pubmed/33812987" target="_blank">33812987</a></div>
<div class="nl"><a target="_blank" href="/pubmed/31387156">Multiple endocrine neoplasia: an update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McDonnell JE,
Gild ML,
Clifton-Bligh RJ,
Robinson BG</span><br />
<span class="medgenPMjournal">Intern Med J</span>
2019 Aug;49(8):954-961.
doi: 10.1111/imj.14394.
<span class="bold">PMID: </span><a href="/pubmed/31387156" target="_blank">31387156</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26363542">Multiple Endocrine Neoplasia: Genetics and Clinical Management.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Norton JA,
Krampitz G,
Jensen RT</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2015 Oct;24(4):795-832.
Epub 2015 Jul 27
doi: 10.1016/j.soc.2015.06.008.
<span class="bold">PMID: </span><a href="/pubmed/26363542" target="_blank">26363542</a><a href="/pmc/articles/PMC4571281" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22723327">Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thakker RV,
Newey PJ,
Walls GV,
Bilezikian J,
Dralle H,
Ebeling PR,
Melmed S,
Sakurai A,
Tonelli F,
Brandi ML;
Endocrine Society</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2012 Sep;97(9):2990-3011.
Epub 2012 Jun 20
doi: 10.1210/jc.2012-1230.
<span class="bold">PMID: </span><a href="/pubmed/22723327" target="_blank">22723327</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1826)</a></div><h3 class="subhead">Diagnosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/31387156">Multiple endocrine neoplasia: an update.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">McDonnell JE,
Gild ML,
Clifton-Bligh RJ,
Robinson BG</span><br />
<span class="medgenPMjournal">Intern Med J</span>
2019 Aug;49(8):954-961.
doi: 10.1111/imj.14394.
<span class="bold">PMID: </span><a href="/pubmed/31387156" target="_blank">31387156</a></div>
<div class="nl"><a target="_blank" href="/pubmed/22723327">Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thakker RV,
Newey PJ,
Walls GV,
Bilezikian J,
Dralle H,
Ebeling PR,
Melmed S,
Sakurai A,
Tonelli F,
Brandi ML;
Endocrine Society</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2012 Sep;97(9):2990-3011.
Epub 2012 Jun 20
doi: 10.1210/jc.2012-1230.
<span class="bold">PMID: </span><a href="/pubmed/22723327" target="_blank">22723327</a></div>
<div class="nl"><a target="_blank" href="/pubmed/20510724">Primary hyperparathyroidism.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Felger EA,
Kandil E</span><br />
<span class="medgenPMjournal">Otolaryngol Clin North Am</span>
2010 Apr;43(2):417-32, x.
doi: 10.1016/j.otc.2010.01.009.
<span class="bold">PMID: </span><a href="/pubmed/20510724" target="_blank">20510724</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18375361">Multiple endocrine neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">White ML,
Doherty GM</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2008 Apr;17(2):439-59, x.
doi: 10.1016/j.soc.2007.12.002.
<span class="bold">PMID: </span><a href="/pubmed/18375361" target="_blank">18375361</a></div>
<div class="nl"><a target="_blank" href="/pubmed/2908316">Multiple endocrine neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Thakker RV,
Ponder BA</span><br />
<span class="medgenPMjournal">Baillieres Clin Endocrinol Metab</span>
1988 Nov;2(4):1031-67.
doi: 10.1016/s0950-351x(88)80029-6.
<span class="bold">PMID: </span><a href="/pubmed/2908316" target="_blank">2908316</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2962)</a></div><h3 class="subhead">Therapy</h3>
<div class="nl"><a target="_blank" href="/pubmed/37925662">Approach to the Patient: Insulinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hofland J,
Refardt JC,
Feelders RA,
Christ E,
de Herder WW</span><br />
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
2024 Mar 15;109(4):1109-1118.
doi: 10.1210/clinem/dgad641.
<span class="bold">PMID: </span><a href="/pubmed/37925662" target="_blank">37925662</a><a href="/pmc/articles/PMC10940262" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/30098725">Lung and Thymic Carcinoids.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Hann CL,
Forde PM</span><br />
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
2018 Sep;47(3):699-709.
doi: 10.1016/j.ecl.2018.04.011.
<span class="bold">PMID: </span><a href="/pubmed/30098725" target="_blank">30098725</a></div>
<div class="nl"><a target="_blank" href="/pubmed/25810047">Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Wells SA Jr,
Asa SL,
Dralle H,
Elisei R,
Evans DB,
Gagel RF,
Lee N,
Machens A,
Moley JF,
Pacini F,
Raue F,
Frank-Raue K,
Robinson B,
Rosenthal MS,
Santoro M,
Schlumberger M,
Shah M,
Waguespack SG;
American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma</span><br />
<span class="medgenPMjournal">Thyroid</span>
2015 Jun;25(6):567-610.
doi: 10.1089/thy.2014.0335.
<span class="bold">PMID: </span><a href="/pubmed/25810047" target="_blank">25810047</a><a href="/pmc/articles/PMC4490627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/23363383">Pharmacotherapy of Zollinger-Ellison syndrome.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ito T,
Igarashi H,
Uehara H,
Jensen RT</span><br />
<span class="medgenPMjournal">Expert Opin Pharmacother</span>
2013 Feb;14(3):307-21.
Epub 2013 Jan 30
doi: 10.1517/14656566.2013.767332.
<span class="bold">PMID: </span><a href="/pubmed/23363383" target="_blank">23363383</a><a href="/pmc/articles/PMC3580316" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/18375361">Multiple endocrine neoplasia.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">White ML,
Doherty GM</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
2008 Apr;17(2):439-59, x.
doi: 10.1016/j.soc.2007.12.002.
<span class="bold">PMID: </span><a href="/pubmed/18375361" target="_blank">18375361</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (509)</a></div><h3 class="subhead">Prognosis</h3>
<div class="nl"><a target="_blank" href="/pubmed/36633525">Cancer statistics, 2023.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Siegel RL,
Miller KD,
Wagle NS,
Jemal A</span><br />
<span class="medgenPMjournal">CA Cancer J Clin</span>
2023 Jan;73(1):17-48.
doi: 10.3322/caac.21763.
<span class="bold">PMID: </span><a href="/pubmed/36633525" target="_blank">36633525</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35319130">Update on the clinical management of multiple endocrine neoplasia type 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pieterman CRC,
Valk GD</span><br />
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
2022 Oct;97(4):409-423.
Epub 2022 Apr 1
doi: 10.1111/cen.14727.
<span class="bold">PMID: </span><a href="/pubmed/35319130" target="_blank">35319130</a><a href="/pmc/articles/PMC9540817" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/9735136">Insulinoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Grant CS</span><br />
<span class="medgenPMjournal">Surg Oncol Clin N Am</span>
1998 Oct;7(4):819-44.
<span class="bold">PMID: </span><a href="/pubmed/9735136" target="_blank">9735136</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7777723">Pheochromocytoma.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Ram CV,
Fierro-Carrion GA</span><br />
<span class="medgenPMjournal">Semin Nephrol</span>
1995 Mar;15(2):126-37.
<span class="bold">PMID: </span><a href="/pubmed/7777723" target="_blank">7777723</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7913021">Multiple endocrine neoplasia type 2. Clinical features and screening.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Raue F,
Frank-Raue K,
Grauer A</span><br />
<span class="medgenPMjournal">Endocrinol Metab Clin North Am</span>
1994 Mar;23(1):137-56.
<span class="bold">PMID: </span><a href="/pubmed/7913021" target="_blank">7913021</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1336)</a></div><h3 class="subhead">Clinical prediction guides</h3>
<div class="nl"><a target="_blank" href="/pubmed/35696052">Thymic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Yliaska I,
Tokola H,
Ebeling T,
Kuismin O,
Ukkola O,
Koivikko ML,
Lesonen T,
Rimpiläinen J,
Felin T,
Ryhänen E,
Metso S,
Schalin-Jäntti C,
Salmela P</span><br />
<span class="medgenPMjournal">Endocrine</span>
2022 Sep;77(3):527-537.
Epub 2022 Jun 13
doi: 10.1007/s12020-022-03099-4.
<span class="bold">PMID: </span><a href="/pubmed/35696052" target="_blank">35696052</a><a href="/pmc/articles/PMC9385812" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35319130">Update on the clinical management of multiple endocrine neoplasia type 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Pieterman CRC,
Valk GD</span><br />
<span class="medgenPMjournal">Clin Endocrinol (Oxf)</span>
2022 Oct;97(4):409-423.
Epub 2022 Apr 1
doi: 10.1111/cen.14727.
<span class="bold">PMID: </span><a href="/pubmed/35319130" target="_blank">35319130</a><a href="/pmc/articles/PMC9540817" target="_blank" class="PubMedFree">Free PMC Article</a></div>
<div class="nl"><a target="_blank" href="/pubmed/27677981">Role of positron emission tomography imaging in Multiple Endocrine Neoplasia syndromes.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">July M,
Santhanam P,
Giovanella L,
Treglia G</span><br />
<span class="medgenPMjournal">Clin Physiol Funct Imaging</span>
2018 Jan;38(1):4-9.
Epub 2016 Sep 27
doi: 10.1111/cpf.12391.
<span class="bold">PMID: </span><a href="/pubmed/27677981" target="_blank">27677981</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26494385">Medullary Thyroid Carcinoma: Imaging.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Delorme S,
Raue F</span><br />
<span class="medgenPMjournal">Recent Results Cancer Res</span>
2015;204:91-116.
doi: 10.1007/978-3-319-22542-5_4.
<span class="bold">PMID: </span><a href="/pubmed/26494385" target="_blank">26494385</a></div>
<div class="nl"><a target="_blank" href="/pubmed/7978894">Genetics of multiple endocrine neoplasia type 1.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Larsson C,
Weber G,
Teh BT,
Lagercrantz J</span><br />
<span class="medgenPMjournal">Ann N Y Acad Sci</span>
1994 Sep 15;733:453-63.
doi: 10.1111/j.1749-6632.1994.tb17295.x.
<span class="bold">PMID: </span><a href="/pubmed/7978894" target="_blank">7978894</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1054)</a></div></div>
</div>
<div class="portlet mgSection" id="ID_104">
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
<div class="portlet_content ln">
<div class="nl"><a target="_blank" href="/pubmed/37668926">Thymoma in multiple endocrine neoplasia type 1: a case report and systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Gao Y,
Li R,
Wu L,
Yang H,
Mao J,
Zhao W</span><br />
<span class="medgenPMjournal">Endocrine</span>
2023 Nov;82(2):442-449.
Epub 2023 Sep 5
doi: 10.1007/s12020-023-03440-5.
<span class="bold">PMID: </span><a href="/pubmed/37668926" target="_blank">37668926</a></div>
<div class="nl"><a target="_blank" href="/pubmed/35767091">Less Than Subtotal Parathyroidectomy for Multiple Endocrine Neoplasia Type 1 Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Bouriez D,
Gronnier C,
Haissaguerre M,
Tabarin A,
Najah H</span><br />
<span class="medgenPMjournal">World J Surg</span>
2022 Nov;46(11):2666-2675.
Epub 2022 Jun 29
doi: 10.1007/s00268-022-06633-7.
<span class="bold">PMID: </span><a href="/pubmed/35767091" target="_blank">35767091</a></div>
<div class="nl"><a target="_blank" href="/pubmed/32914730">Molecular Diagnosis and Treatment of Multiple Endocrine Neoplasia Type 2B in Ethnic Han Chinese.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang ZW,
Guo X,
Qi XP</span><br />
<span class="medgenPMjournal">Endocr Metab Immune Disord Drug Targets</span>
2021;21(3):534-543.
doi: 10.2174/1871530320666200910112230.
<span class="bold">PMID: </span><a href="/pubmed/32914730" target="_blank">32914730</a></div>
<div class="nl"><a target="_blank" href="/pubmed/26898681">Risk-reduction surgery in pediatric surgical oncology: A perspective.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Sandoval JA,
Fernandez-Pineda I,
Malkan AD</span><br />
<span class="medgenPMjournal">J Pediatr Surg</span>
2016 Apr;51(4):675-87.
Epub 2016 Feb 3
doi: 10.1016/j.jpedsurg.2016.01.004.
<span class="bold">PMID: </span><a href="/pubmed/26898681" target="_blank">26898681</a></div>
<div class="nl"><a target="_blank" href="/pubmed/24972642">The association between Hirschsprung's disease and multiple endocrine neoplasia type 2a: a systematic review.</a></div>
<div class="portlet_content ln"><span class="medgenPMauthor">Coyle D,
Friedmacher F,
Puri P</span><br />
<span class="medgenPMjournal">Pediatr Surg Int</span>
2014 Aug;30(8):751-6.
Epub 2014 Jun 28
doi: 10.1007/s00383-014-3538-2.
<span class="bold">PMID: </span><a href="/pubmed/24972642" target="_blank">24972642</a></div>
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Multiple%20endocrine%20neoplasia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (22)</a></div></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C0027662%5bDISCUI%5d&amp;filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
<li><a href="/gtr/tests?term=C0027662%5bDISCUI%5d&amp;filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (12)</a></li>
<li><a href="/gtr/tests?term=C0027662%5bDISCUI%5d&amp;filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C0027662%5bDISCUI%5d" target="_blank">See all (13)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/phenotypicSeries/PS131100" target="_blank">OMIM</a></li><li><a href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=276161" target="_blank">Orphanet</a></li><li><a href="https://clinicaltrials.gov/search?cond=Multiple%20endocrine%20neoplasia" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22multiple%20endocrine%20neoplasia%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Multiple%20endocrine%20neoplasia%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023</div></li></ul></div>
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