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<meta name="keywords" content="CN033288, brca2, disease or syndrome, gpc3, gpc4, h19, igf2, nephroblastoma, wilms tumor 1, wilms tumor type 1, wilms tumor, autosomal dominant, somatic mutation, wilms tumor, somatic, wilms tumor, type 1, autosomal dominant, somatic mutation, wilms tumour type 1, wt1, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="PAX6-related aniridia occurs either as an isolated ocular abnormality or as part of the Wilms tumor-aniridia-genital anomalies-retardation (WAGR) syndrome. Aniridia is a pan ocular disorder affecting the cornea, iris, intraocular pressure (resulting in glaucoma), lens (cataract and lens subluxation), fovea (foveal hypoplasia), and optic nerve (optic nerve coloboma and hypoplasia). Individuals with aniridia characteristically show nystagmus and impaired visual acuity (usually 20/100 - 20/200); however, milder forms of aniridia with subtle iris architecture changes, good vision, and normal foveal structure do occur. Other ocular involvement may include strabismus and occasionally microphthalmia. Although the severity of aniridia can vary between and within families, little variability is usually observed in the two eyes of an affected individual. WAGR syndrome. The risk for Wilms tumor is 42.5%-77%; of those who develop Wilms tumor, 90% do so by age four years and 98% by age seven years. Genital anomalies in males can include cryptorchidism and hypospadias (sometimes resulting in ambiguous genitalia), urethral strictures, ureteric abnormalities, and gonadoblastoma. While females typically have normal external genitalia, they may have uterine abnormalities and streak ovaries. Intellectual disability (defined as IQ <74) is observed in 70%; behavioral abnormalities include attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, anxiety, depression, and obsessive-compulsive disorder. Other individuals with WAGR syndrome can have normal intellect without behavioral issues." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=447509
|
||
ConceptID=CN033288
|
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-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Wilms tumor 1<span class="h1sub">(WT1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>447509</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information.">CN033288</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Wilms tumor, somatic; WT1</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="BRCA2 - ID: 675 - NCBI Gene" href="/gene/675" class="medgenPMinfo">BRCA2</a> (13q13.1); <a target="_blank" title="GPC3 - ID: 2719 - NCBI Gene" href="/gene/2719" class="medgenPMinfo">GPC3</a> (Xq26.2); <a target="_blank" title="GPC4 - ID: 2239 - NCBI Gene" href="/gene/2239" class="medgenPMinfo">GPC4</a> (Xq26.2); <a target="_blank" title="H19 - ID: 283120 - NCBI Gene" href="/gene/283120" class="medgenPMinfo">H19</a> (11p15.5); <a target="_blank" title="IGF2 - ID: 3481 - NCBI Gene" href="/gene/3481" class="medgenPMinfo">IGF2</a> (11p15.5); <a target="_blank" title="WT1 - ID: 7490 - NCBI Gene" href="/gene/7490" class="medgenPMinfo">WT1</a> (11p13)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0008679" target="_blank">MONDO:0008679</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/194070" target="_blank">194070</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">PAX6-related aniridia occurs either as an isolated ocular abnormality or as part of the Wilms tumor-aniridia-genital anomalies-retardation (WAGR) syndrome. Aniridia is a pan ocular disorder affecting the cornea, iris, intraocular pressure (resulting in glaucoma), lens (cataract and lens subluxation), fovea (foveal hypoplasia), and optic nerve (optic nerve coloboma and hypoplasia). Individuals with aniridia characteristically show nystagmus and impaired visual acuity (usually 20/100 - 20/200); however, milder forms of aniridia with subtle iris architecture changes, good vision, and normal foveal structure do occur. Other ocular involvement may include strabismus and occasionally microphthalmia. Although the severity of aniridia can vary between and within families, little variability is usually observed in the two eyes of an affected individual. WAGR syndrome. The risk for Wilms tumor is 42.5%-77%; of those who develop Wilms tumor, 90% do so by age four years and 98% by age seven years. Genital anomalies in males can include cryptorchidism and hypospadias (sometimes resulting in ambiguous genitalia), urethral strictures, ureteric abnormalities, and gonadoblastoma. While females typically have normal external genitalia, they may have uterine abnormalities and streak ovaries. Intellectual disability (defined as IQ <74) is observed in 70%; behavioral abnormalities include attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, anxiety, depression, and obsessive-compulsive disorder. Other individuals with WAGR syndrome can have normal intellect without behavioral issues. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Wilms tumor is the most common renal tumor of childhood, occurring with an incidence of 1 in 10,000 and with a median age of diagnosis between 3 and 4 years of age. Wilms tumors are thought to develop from abnormally persistent embryonal cells within nephrogenic rests. Histologically, Wilms tumor mirrors the development of the normal kidney and classically consists of 3 cell types: blastema, epithelia, and stroma (summary by Slade et al., 2010).
|
||
Genetic Heterogeneity of Wilms Tumor
|
||
Susceptibility to Wilms tumor is genetically heterogeneous. WT2 (194071) is caused by mutation in the H19/IGF2-imprinting control region (ICR1; 616186) on chromosome 11p15. WT3 (194090) represents a locus mapped to chromosome 16q. WT4 (601363) represents a locus mapped to chromosome 17q12-q21. WT5 (601583) is caused by mutation in the POU6F2 gene (609062) on chromosome 7p14. WT6 (616806) is caused by mutation in the REST gene (600571) on chromosome 4q12.
|
||
Mutations in the BRCA2 gene (600185) have also been reported in Wilms tumor. Rare somatic and constitutional disruption of the HACE1 gene (610876) has also been reported in Wilms tumor.
|
||
Somatic mutations in the glypican-3 gene (GPC3; 300037) have been described in Wilms tumor. Somatic mutations in the WTX gene (300647) on the single X allele in tumors from males and on the active X allele in tumors from females have also been described. <a target="_blank" href="http://www.omim.org/entry/194070">http://www.omim.org/entry/194070</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Wilms tumor is a form of kidney cancer that primarily develops in children. Nearly all cases of Wilms tumor are diagnosed before the age of 10, with two-thirds being found before age 5.<br /><br />Wilms tumor is often first noticed because of abdominal swelling or a mass in the kidney that can be felt upon physical examination. Some affected children have abdominal pain, fever, a low number of red blood cells (anemia), blood in the urine (hematuria), or high blood pressure (hypertension). Additional signs of Wilms tumor can include loss of appetite, weight loss, nausea, vomiting, and tiredness (lethargy).<br /><br />Wilms tumor can develop in one or both kidneys. About 5 to 10 percent of affected individuals develop multiple tumors in one or both kidneys. Wilms tumor may spread from the kidneys to other parts of the body (metastasize). In rare cases, Wilms tumor does not involve the kidneys and occurs instead in the genital tract, bladder, abdomen, chest, or lower back. It is unclear how Wilms tumor develops in these tissues.<br /><br />With proper treatment, children with Wilms tumor have a 90 percent survival rate. However, the risk that the cancer will come back (recur) is between 15 and 50 percent, depending on traits of the original tumor. Tumors usually recur in the first 2 years following treatment and develop in the kidneys or other tissues, such as the lungs. Individuals who have had Wilms tumor may experience related health problems or late effects of their treatment in adulthood, such as decreased kidney function, heart disease, and development of additional cancers. <a target="_blank" href="https://medlineplus.gov/genetics/condition/wilms-tumor">https://medlineplus.gov/genetics/condition/wilms-tumor</a></div></div>
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||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_118">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0027708[DISCUI]&test_type=Clinical" ref="ncbi_uid=10221">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=10221" target="_blank" href="/omim/194070">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=10221" ref="ncbi_uid=10221">V</a></span></span><span class="TLline"><a href="/medgen/10221" ref="tree=GTR&ncbi_uid=10221&link_uid=10221" title="View MedGen record for 'Nephroblastoma'">Nephroblastoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/989515" ref="tree=GTR&ncbi_uid=989515&link_uid=989515" title="View MedGen record for 'Kidney Wilms tumor'">Kidney Wilms tumor</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0677779[DISCUI]&test_type=Clinical" ref="ncbi_uid=146190">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/146190" ref="tree=GTR&ncbi_uid=146190&link_uid=146190" title="View MedGen record for 'Hereditary Wilms tumor'">Hereditary Wilms tumor</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN033288[DISCUI]&test_type=Clinical" ref="ncbi_uid=447509">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK1294%20OR%20NBK1360%20OR%20NBK556455)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=447509">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=447509" ref="ncbi_uid=447509">V</a></span></span><span class="TLline">Wilms tumor 1</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C3887743[DISCUI]&test_type=Clinical" ref="ncbi_uid=854562">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=854562" target="_blank" href="/omim/194071">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=854562">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=854562" ref="ncbi_uid=854562">V</a></span></span><span class="TLline"><a href="/medgen/854562" ref="tree=GTR&ncbi_uid=854562&link_uid=854562" title="View MedGen record for 'Wilms tumor 2'">Wilms tumor 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1860265[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=349770">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=349770" target="_blank" href="/omim/194090">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=349770">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/349770" ref="tree=GTR&ncbi_uid=349770&link_uid=349770" title="View MedGen record for 'Wilms tumor 3'">Wilms tumor 3</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1832426[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=318623">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=318623" target="_blank" href="/omim/601363">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1294/" ref="ncbi_uid=318623">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/318623" ref="tree=GTR&ncbi_uid=318623&link_uid=318623" title="View MedGen record for 'Wilms tumor 4'">Wilms tumor 4</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1832099[DISCUI]&test_type=Clinical" ref="ncbi_uid=316905">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=316905" target="_blank" href="/omim/601583">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=316905" ref="ncbi_uid=316905">V</a></span></span><span class="TLline"><a href="/medgen/316905" ref="tree=GTR&ncbi_uid=316905&link_uid=316905" title="View MedGen record for 'Wilms tumor 5'">Wilms tumor 5</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/232504" ref="tree=MeSH" title="MedGen record for Hereditary cancer">Hereditary cancer</a></span><ul><li><span class="TLline"><a href="/medgen/1650763" ref="tree=MeSH" title="MedGen record for Hereditary Malignant Urinary System Neoplasm">Hereditary Malignant Urinary System Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/146190" ref="tree=MeSH" title="MedGen record for Hereditary Wilms tumor">Hereditary Wilms tumor</a></span><ul><li><span class="matched_ds">Wilms tumor 1</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28673850">Clinical Utility of Wilms' Tumor 1 Monitoring in Patients with Myeloid Malignancy and Prior Allogeneic Hematopoietic Stem Cell Transplantation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ino K,
|
||
Fuji S,
|
||
Tajima K,
|
||
Tanaka T,
|
||
Okinaka K,
|
||
Inamoto Y,
|
||
Kurosawa S,
|
||
Kim SW,
|
||
Katayama N,
|
||
Fukuda T</span><br />
|
||
<span class="medgenPMjournal">Biol Blood Marrow Transplant</span>
|
||
2017 Oct;23(10):1780-1787.
|
||
Epub 2017 Jun 30
|
||
doi: 10.1016/j.bbmt.2017.06.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28673850" target="_blank">28673850</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22208496">Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chekol SS,
|
||
Sun CC</span><br />
|
||
<span class="medgenPMjournal">Arch Pathol Lab Med</span>
|
||
2012 Jan;136(1):113-7.
|
||
doi: 10.5858/arpa.2010-0550-RS.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22208496" target="_blank">22208496</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21108447">Suggested change in definitional criteria for stage 1 Wilms tumor treated by surgery only.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Beckwith JB</span><br />
|
||
<span class="medgenPMjournal">Pediatr Blood Cancer</span>
|
||
2011 Jan;56(1):168; author reply 169-70.
|
||
doi: 10.1002/pbc.22745.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21108447" target="_blank">21108447</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22wilms%20tumor%201%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (15)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nccn.org/professionals/physician_gls/pdf/wilms_tumor.pdf" target="_blank">NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Wilms Tumor (Nephroblastoma), 2023</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39007267">Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ge Y,
|
||
Chen R,
|
||
Ling T,
|
||
Liu B,
|
||
Huang J,
|
||
Cheng Y,
|
||
Lin Y,
|
||
Chen H,
|
||
Xie X,
|
||
Xia G,
|
||
Luo G,
|
||
Yuan S,
|
||
Xu A</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2024 May 16;134(14)
|
||
doi: 10.1172/JCI177932.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39007267" target="_blank">39007267</a><a href="/pmc/articles/PMC11245160" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36905177">Wilms' tumor 1 expression combined with genetic mutations for prognostic assessment in MDS.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pan D,
|
||
Zhao W,
|
||
Jiang Q,
|
||
Yin C,
|
||
He H,
|
||
Liao L,
|
||
Ye J,
|
||
Dai M</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
2023 Apr;64(4):856-864.
|
||
Epub 2023 Mar 11
|
||
doi: 10.1080/10428194.2023.2185086.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36905177" target="_blank">36905177</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36608137">TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang YQ,
|
||
Wu DH,
|
||
Wei D,
|
||
Shen JY,
|
||
Huang ZW,
|
||
Liang XY,
|
||
Cho WCS,
|
||
Ma J,
|
||
Lv J,
|
||
Chen YP</span><br />
|
||
<span class="medgenPMjournal">Sci Adv</span>
|
||
2023 Jan 6;9(1):eadd0960.
|
||
doi: 10.1126/sciadv.add0960.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36608137" target="_blank">36608137</a><a href="/pmc/articles/PMC9821866" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30609023">Curcumin as a therapeutic agent in leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kouhpeikar H,
|
||
Butler AE,
|
||
Bamian F,
|
||
Barreto GE,
|
||
Majeed M,
|
||
Sahebkar A</span><br />
|
||
<span class="medgenPMjournal">J Cell Physiol</span>
|
||
2019 Aug;234(8):12404-12414.
|
||
Epub 2019 Jan 4
|
||
doi: 10.1002/jcp.28072.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30609023" target="_blank">30609023</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26992216">The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Long J,
|
||
Fang S,
|
||
Dai Q,
|
||
Liu X,
|
||
Zhu W,
|
||
Wang S</span><br />
|
||
<span class="medgenPMjournal">Oncotarget</span>
|
||
2016 May 31;7(22):32079-87.
|
||
doi: 10.18632/oncotarget.8117.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26992216" target="_blank">26992216</a><a href="/pmc/articles/PMC5077998" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (217)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36905177">Wilms' tumor 1 expression combined with genetic mutations for prognostic assessment in MDS.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pan D,
|
||
Zhao W,
|
||
Jiang Q,
|
||
Yin C,
|
||
He H,
|
||
Liao L,
|
||
Ye J,
|
||
Dai M</span><br />
|
||
<span class="medgenPMjournal">Leuk Lymphoma</span>
|
||
2023 Apr;64(4):856-864.
|
||
Epub 2023 Mar 11
|
||
doi: 10.1080/10428194.2023.2185086.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36905177" target="_blank">36905177</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29407184">Prognostic significance of The Wilms' Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Petiti J,
|
||
Rosso V,
|
||
Lo Iacono M,
|
||
Calabrese C,
|
||
Signorino E,
|
||
Gaidano V,
|
||
Berger M,
|
||
Saglio G,
|
||
Cilloni D</span><br />
|
||
<span class="medgenPMjournal">Leuk Res</span>
|
||
2018 Apr;67:6-11.
|
||
Epub 2018 Feb 5
|
||
doi: 10.1016/j.leukres.2018.01.016.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29407184" target="_blank">29407184</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28542793">The genetic factors contributing to the development of Wilm's tumor and their clinical utility in its diagnosis and prognosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bahrami A,
|
||
Joodi M,
|
||
Maftooh M,
|
||
Ferns GA,
|
||
M Ahmadi M,
|
||
Hassanian SM,
|
||
Avan A</span><br />
|
||
<span class="medgenPMjournal">J Cell Physiol</span>
|
||
2018 Apr;233(4):2882-2888.
|
||
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<div class="nl"><a target="_blank" href="/pubmed/31438961">WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/30609023">Curcumin as a therapeutic agent in leukemia.</a></div>
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Butler AE,
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Bamian F,
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Barreto GE,
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Majeed M,
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Sahebkar A</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/36608137">TEAD4 is a master regulator of high-risk nasopharyngeal carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Wang YQ,
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Wu DH,
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Wei D,
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Shen JY,
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Huang ZW,
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Liang XY,
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Cho WCS,
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<div class="nl"><a target="_blank" href="/pubmed/33726497">Single-Cell RNA Sequencing Uncovers Paracrine Functions of the Epicardial-Derived Cells in Arrhythmogenic Cardiomyopathy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yuan P,
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Cheedipudi SM,
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Rouhi L,
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Fan S,
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Simon L,
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Zhao Z,
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Hong K,
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Gurha P,
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Marian AJ</span><br />
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<span class="medgenPMjournal">Circulation</span>
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<span class="bold">PMID: </span><a href="/pubmed/33726497" target="_blank">33726497</a><a href="/pmc/articles/PMC8169643" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/31438961">WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chen Y,
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Peng C,
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Chen J,
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Chen D,
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Yang B,
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He B,
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Hu W,
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Zhang Y,
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Liu H,
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Dai L,
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Xie H,
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Zhou L,
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Wu J,
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Zheng S</span><br />
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<span class="medgenPMjournal">Mol Cancer</span>
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doi: 10.1186/s12943-019-1053-8.
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<span class="bold">PMID: </span><a href="/pubmed/31438961" target="_blank">31438961</a><a href="/pmc/articles/PMC6704583" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (265)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/38837193">Association between birth weight and risk of nonneurological childhood cancers: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Rashti R,
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Ghasemi F,
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Poorolajal J</span><br />
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<span class="medgenPMjournal">Eur J Cancer Prev</span>
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Epub 2024 May 20
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doi: 10.1097/CEJ.0000000000000894.
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<span class="bold">PMID: </span><a href="/pubmed/38837193" target="_blank">38837193</a></div>
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||
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<div class="nl"><a target="_blank" href="/pubmed/32629644">Association between the Wilms tumor-1 rs16754 polymorphism and acute myeloid leukemia: A MOOSE-compliant meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yu X,
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Zhang Y,
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Liu S,
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Mu Y,
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Shang F,
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Zhang N</span><br />
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<span class="medgenPMjournal">Medicine (Baltimore)</span>
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<span class="bold">PMID: </span><a href="/pubmed/32629644" target="_blank">32629644</a><a href="/pmc/articles/PMC7337456" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25748047">Wilms' tumor 1 (WT1) expression and prognosis in solid cancer patients: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Qi XW,
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Zhang F,
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Wu H,
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Liu JL,
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Zong BG,
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Xu C,
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Jiang J</span><br />
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|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilms%20tumor%201%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
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|
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|
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|
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|
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|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
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<!-- MedGen supplemental column starts here -->
|
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<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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|
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|
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<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (99)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (2)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (4)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (10)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (97)</a></li>
|
||
<li><a href="/gtr/tests?term=CN033288%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (27)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=CN033288%5bDISCUI%5d" target="_blank">See all (136)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22wilms%20tumor%201%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Wilms%20tumor%201%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nccn.org/professionals/physician_gls/pdf/wilms_tumor.pdf">NCCN, 2023</a><div>NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Wilms Tumor (Nephroblastoma), 2023</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=103280%20147470%20300037%20300168%20600185%20607102" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=675[geneid]" target="_blank">View BRCA2 variations in ClinVar</a></li><li><a href="/clinvar/?term=2239[geneid]" target="_blank">View GPC4 variations in ClinVar</a></li><li><a href="/clinvar/?term=2719[geneid]" target="_blank">View GPC3 variations in ClinVar</a></li><li><a href="/clinvar/?term=3481[geneid]" target="_blank">View IGF2 variations in ClinVar</a></li><li><a href="/clinvar/?term=7490[geneid]" target="_blank">View WT1 variations in ClinVar</a></li><li><a href="/clinvar/?term=283120[geneid]" target="_blank">View H19 variations in ClinVar</a></li><li><a href="/nuccore/209977069,219802195,219842201,254826767,256574794,270309105" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=194070" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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